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1. Muñoz-Guerra MF, Nieto S, Capote AL, Rodríguez-Campo FJ, Naval-Gías L: Undifferentiated carcinoma arising from the Stensen's duct: a case report and review of the literature. Am J Otolaryngol; 2005 Nov-Dec;26(6):415-8
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  • [Title] Undifferentiated carcinoma arising from the Stensen's duct: a case report and review of the literature.
  • Primary carcinoma arising in Stensen's duct is an extremely rare and poorly understood tumor.
  • Microscopic examination revealed tumor cells of basaloid pattern with squamous differentiation in some areas.
  • Primary carcinoma of Stensen's duct should be histologically consistent with epidermoid, mucoepidermoid, or undifferentiated carcinoma.
  • The diagnosis of true Stensen's duct carcinoma can be performed on the basis of clinical presentation, radiological findings, and tumor histology.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Parotid Neoplasms / pathology. Salivary Ducts

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  • (PMID = 16275415.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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2. Duvall E: The use of the 'borderline' category in the reporting of cervical cytopathology in the UK: results of a survey conducted under the aegis of the British Society for Clinical Cytology. Cytopathology; 2008 Jun;19(3):167-71
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  • RESULTS: There is wide variation in the use of the 'borderline' category in the UK but the majority of respondents (77.6%) used it when reporting smears that were either on the borderline between negative and low grade squamous dyskaryosis ('borderline ?low grade'), or on the borderline between negative and high grade squamous dyskaryosis ('borderline ?high grade'), or on the borderline between negative and glandular dyskaryosis 'borderline ?glandular dyskaryosis').
  • A significant minority (15.7%), however, did not use 'borderline' when reporting smears that showed an abnormality that was possibly high grade squamous dyskaryosis.
  • The proposed revised BSCC terminology with separate categories for borderline ?low grade, borderline ?high grades and borderline ?
  • [MeSH-major] Pathology, Clinical / standards. Precancerous Conditions / diagnosis. Professional Practice / standards. Uterine Cervical Neoplasms / diagnosis


3. Szendroi M, Antal I, Arató G: Adamantinoma of long bones: a long-term follow-up study of 11 cases. Pathol Oncol Res; 2009 Jun;15(2):209-16
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  • The initial diagnosis at referral was other than adamantinoma in six patients (fibrous dysplasia, carcinoma metastasis, osteofibrous dysplasia, bone cyst, non-ossifying fibroma), referring to the differential diagnostic problems.
  • By histological evaluation, basaloid pattern on a background of fibrotic stroma dominated in six patients, while spindle and squamous features were less frequently seen.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Prognosis. Survival Rate. Young Adult

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  • (PMID = 19048403.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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4. Takemura M, Morimura K, Yoshida K, Fujiwara Y: [Four resected cases with basaloid carcinoma of esophagus--comparison of 5-FU-related enzymes (thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT)) between basaloid carcinoma and squamous cell carcinoma]. Gan To Kagaku Ryoho; 2010 Nov;37(11):2143-6
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  • [Title] [Four resected cases with basaloid carcinoma of esophagus--comparison of 5-FU-related enzymes (thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT)) between basaloid carcinoma and squamous cell carcinoma].
  • We reported herein four resected cases with basaloid carcinoma of the esophagus and measured the activity of 5-FU related enzymes (TS, DPD, OPRT) in cancer tissue.
  • These activities compared with those in squamous cell carcinoma.
  • Only one case was diagnosed as basaloid carcinoma by preoperative biopsy specimen at endoscopic examination.
  • DPD activity and OPRT activity showed no difference between squamous cell carcinoma and basaloid carcinoma.
  • On the other hand, the TS activity was significantly higher in basaloid carcinoma.
  • From the standpoint of 5-FU-related enzyme activities, basaloid carcinoma possibly has more resistance to 5-FU than squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / enzymology. Carcinoma, Squamous Cell / enzymology. Dihydrouracil Dehydrogenase (NADP) / metabolism. Esophageal Neoplasms / enzymology. Orotate Phosphoribosyltransferase / metabolism. Thymidylate Synthase / metabolism

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  • (PMID = 21084814.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; EC 1.3.1.2 / Dihydrouracil Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; EC 2.4.2.10 / Orotate Phosphoribosyltransferase; U3P01618RT / Fluorouracil
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5. van Neer PL, Bouakaz A, Vlaanderen E, de Hart J, van de Vosse FN, van der Steen AF, de Jong N: Detecting broken struts of a Björk-Shiley heart valve using ultrasound: a feasibility study. Ultrasound Med Biol; 2006 Apr;32(4):503-12
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  • The Björk-Shiley (BScc) mechanical heart valve has extensively been used in surgery from 1979 to 1986.
  • Many approaches have been attempted to noninvasively determine BScc valve integrity.
  • In our study we analyze leg movement of the BScc valves outlet strut during the cardiac cycle with ultrasound.
  • BScc valves were mounted in the mitral position in an in vitro pulse duplicator system.
  • The results showed no significant difference in movement between both legs of the outlet strut of the intact BScc valve (amplitude of movement 9.2 microm +/- 0.1 microm).
  • In conclusion, the proposed method has shown to be feasible in vitro and has potentials for in vivo detection of BScc valve outlet strut fracture.

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  • (PMID = 16616597.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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6. Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T: Histological diversity in basaloid squamous cell carcinoma of the esophagus. Dis Esophagus; 2009;22(3):231-8
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  • [Title] Histological diversity in basaloid squamous cell carcinoma of the esophagus.
  • Basaloid squamous cell carcinoma of the esophagus (BSCCE) is a distinct variant of esophageal cancer.
  • Histological features were classified into five components: solid nest (SN), microcyst and/or trabecular nest (MT), ductal differentiation (DD), cribriform pattern (CP), and an invasive squamous cell carcinoma (SCC) component.


7. Kwon YS, Kim YM, Choi GW, Kim YT, Nam JH: Pure basaloid squamous cell carcinoma of the uterine cervix: a case report. J Korean Med Sci; 2009 Jun;24(3):542-5
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  • [Title] Pure basaloid squamous cell carcinoma of the uterine cervix: a case report.
  • Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare malignancy of the female genital tract with a poorer clinical outcome than squamous cell carcinoma of the uterine cervix.
  • We report a case of pure basaloid squamous cell carcinoma of the uterine cervix.
  • A basaloid squamous cell carcinoma of the uterine cervix, of International Federation of Gynecology and Obstetrics (FIGO) stage Ib1, was diagnosed by a loop electrosurgical excision procedure cone biopsy.
  • Pathologic findings were consistent with a basaloid squamous cell carcinoma confined to the cervix without an extracervical tumor.
  • Although basaloid squamous cell carcinoma of the uterine cervix is thought to behave aggressively, accumulation of data on these rare tumors is necessary to determine whether their behavior differs significantly from that of conventional cervical squamous cell carcinoma of similar clinical stage.
  • These data would be useful for defining the best diagnosis and treatment for these rare tumors.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Uterine Cervical Neoplasms / diagnosis


8. Bellizzi AM, Woodford RL, Moskaluk CA, Jones DR, Kozower BD, Stelow EB: Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. Am J Surg Pathol; 2009 Nov;33(11):1608-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers.
  • Basaloid squamous cell carcinoma (BSCC) of the esophagus is rare, historically confused for adenoid cystic carcinoma, and recently shown to behave similar to conventional, keratinizing esophageal squamous cell carcinoma.
  • At other sites (eg, oropharynx, anogenital tract) the basaloid phenotype is frequently associated with the presence of high-risk human papillomavirus (HPV).
  • HPVs role in esophageal squamous cell carcinomas is less certain, and to our knowledge, a direct examination of esophageal BSCC for high-risk HPV has not been performed earlier.
  • Nine cases of esophageal BSCC were retrieved from our surgical pathology files.
  • Twenty-two cases of keratinizing esophageal squamous cell carcinoma served as controls.
  • Compared with controls, BSCC showed less immunoreactivity for p16 and p53 (P=0.003, 0.009).
  • Esophageal BSCC is negative for high-risk HPV by ISH, distinguishing these lesions from other BSCCs.
  • Differential p16 and p53 expression in BSCC suggests that these tumors are molecularly distinct from conventional esophageal squamous cell carcinomas.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma, Basal Cell / virology. Carcinoma, Basosquamous / virology. Carcinoma, Squamous Cell / virology. Esophageal Neoplasms / virology. Papillomavirus Infections / complications


9. Joshi D, Shivkumar VB, Sharma SM, Gangane N: Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report. Acta Cytol; 2009 Jan-Feb;53(1):89-92
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  • [Title] Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report.
  • BACKGROUND: Basaloid squamous cell carcinoma is a high-grade variant of squamous cell carcinoma that most commonly occurs in the upper aerodigestive tract.
  • The authors describe the cytologic features of a histologically confirmed case of basaloid squamous cell carcinoma arising in the floor of the mouth.
  • Extracellular basement membrane-like material was also noted, which led to the erroneous diagnosis of adenoid cystic carcinoma.
  • Histopathology characteristically revealed the presence of squamoid nests between malignant basaloid cells, and the tumor was finally diagnosed as basaloid squamous cell carcinoma.
  • CONCLUSION: Basaloid squamous cell carcinoma should be considered in the differential diagnosis of tumors arising in oral cavity.
  • Cytologic diagnosis may be difficult, but careful search for a second cell population of squamoid cells in addition to small basaloid cells may aid in rendering the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Middle Aged

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  • (PMID = 19248560.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Gurfinkel R, Walfisch S: Combined treatment of basaloid anal carcinoma using cisplatin, 5-fluorouracil and resection of hepatic metastasis. Tech Coloproctol; 2005 Dec;9(3):235-6
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  • [Title] Combined treatment of basaloid anal carcinoma using cisplatin, 5-fluorouracil and resection of hepatic metastasis.
  • The combination of chemotherapy and radiotherapy with subsequent repeated local biopsy has become the standard treatment of epidermoid carcinoma.
  • The optimal treatment of metastatic anal carcinomas is controversial.
  • We present the case of 54-year-old woman with a diagnosis of metastatic basaloid anal carcinoma.
  • The patient underwent resection of liver metastasis in combination with cisplatin + 5FU and local radiotherapy, without evident disease 3 years after diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / secondary. Hepatectomy / methods. Liver Neoplasms / secondary. Liver Neoplasms / therapy

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  • (PMID = 16328122.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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11. Slater DN, Rice S, Stewart R, Melling SE, Hewer EM, Smith JH: Proposed Sheffield quantitative criteria in cervical cytology to assist the grading of squamous cell dyskaryosis, as the British Society for Clinical Cytology definitions require amendment. Cytopathology; 2005 Aug;16(4):179-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proposed Sheffield quantitative criteria in cervical cytology to assist the grading of squamous cell dyskaryosis, as the British Society for Clinical Cytology definitions require amendment.
  • OBJECTIVE: In 1986, the British Society for Clinical Cytology (BSCC) published quantitative criteria to assist diagnosis in a three-tier grading system of squamous cell dyskaryosis.
  • Following the Terminology Conference in 2002, however, the BSCC recommended on their website that the three-tier model should be replaced by a new two-tier system of low- and high-grade squamous abnormalities.
  • The latter broadly equate with the two-grade Bethesda System (TBS) for reporting squamous intraepithelial lesions.
  • The purpose of this study was to assess the accuracy and reproducibility of the BSCC three-tier quantitative definitions, to investigate if they were applicable to liquid-based cytology (LBC) and to see how they related to the proposed new two-tier BSCC system.
  • METHODS: Quantitative image analysis was undertaken on illustrations from the 1986 BSCC terminology publication and on microscope slides from external quality assessment and Cytology Training Centre teaching sets.
  • No grade of dyskaryosis had a mean area NC ratio over 50%, indicating that the BSCC quantitative definitions are incorrect.
  • Accordingly it is possible that those reporting cervical cytology could be interpreting the BSCC NC ratios as meaning diameter rather than area.
  • The similar NC ratios of borderline nuclear changes associated with human papilloma virus and mild dyskaryosis support the BSCC proposal that these can be combined to constitute a low-grade category.
  • This study shows that the BSCC area NC ratio criteria of grading squamous cell dyskaryosis require amendment.
  • In addition, this study supports the new BSCC recommendation of low- and high-grade squamous cell categories.
  • CONCLUSIONS: The study proposes Sheffield quantitative criteria to assist the grading of squamous cell abnormalities.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Cervical Intraepithelial Neoplasia / diagnosis. Cytodiagnosis / methods. Terminology as Topic. Uterine Cervical Dysplasia / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Cell Nucleus Structures / pathology. Cell Nucleus Structures / ultrastructure. Female. Great Britain. Humans. Image Cytometry / standards. Societies, Medical


12. Salerno G, Di Vizio D, Staibano S, Mottola G, Quaremba G, Mascolo M, Galli V, De Rosa G, Insabato L: Prognostic value of p27Kip1 expression in Basaloid Squamous Cell Carcinoma of the larynx. BMC Cancer; 2006;6:146
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  • [Title] Prognostic value of p27Kip1 expression in Basaloid Squamous Cell Carcinoma of the larynx.
  • BACKGROUND: Very few reports have investigated the role of cell cycle regulators as biomarkers in Basaloid Squamous Cell Carcinoma (BSCC) of the larynx, a definite morphologic, uncommon, very aggressive variant of squamous cell carcinoma.
  • Lower expression of Ki67/Mib-1, a proliferation marker highly expressed in the majority of tumours, and p53, a tumour suppressor protein that can induce an arrest of the G1-S transition, was related to a better prognosis in laryngeal BSCC.
  • Up to date the role of this protein was never studied in BSCC.
  • Aim of our study was to investigate the potential prognostic value of p27kip1 levels and their correlation with Ki67/Mib-1 and p53 expression in BSCC of the larynx.
  • METHODS: The retrospective study group consisted of 15 male and 1 female patients, affected by laryngeal BSCC, ranging in age from 44 to 69 years (mean 58).
  • In our series of laryngeal BSCC the resulting data seem to confirm the clinical prognostic relevance of p27kip1 low expression, which directly correlated with biological aggressiveness and consequent shortened survival.
  • [MeSH-major] Biomarkers / analysis. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / metabolism

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  • (PMID = 16740156.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CDKN1B protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ PMC1559634
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13. Yu L, Galan A, McNiff JM: Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma. J Cutan Pathol; 2009 Oct;36(10):1074-176
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  • [Title] Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma.
  • BACKGROUND: Superficial skin biopsies of basal cell carcinoma (BCC) represent some of the most common dermatopathology specimens.
  • Superficial shave biopsies containing partial samples of lesions with squamatization present difficulties in distinguishing BCC from squamous cell carcinoma (SCC).
  • METHODS: We collected 12 cases of superficial biopsies of BCC with centrally located cords and strands suggesting squamous differentiation at the Yale Dermatopathology Laboratory over a 3-month period and stained them with BerEP4.
  • RESULTS: We found that all cases (12 out of 12) showed membranous and cytoplasmic staining with BerEP4 in the obvious areas of basaloid differentiation at the periphery of the tumors, while cords and strands of enlarged cells with squamoid features in the center and surface of the biopsy failed to label with BerEP4.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Staining and Labeling


14. Scurry J, Wilkinson EJ: Review of terminology of precursors of vulvar squamous cell carcinoma. J Low Genit Tract Dis; 2006 Jul;10(3):161-9
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  • [Title] Review of terminology of precursors of vulvar squamous cell carcinoma.
  • The popular term for vulvar squamous cell carcinoma in situ/dysplasia is vulvar intraepithelial neoplasia (VIN).
  • VIN is a histological diagnosis based on loss of squamous epithelial maturation associated with enlarged, hyperchromatic, pleomorphic nuclei and increased, usually atypical mitoses.
  • There are two types of VIN: the usual (not otherwise specified) type, also known as warty-basaloid, and the differentiated type.
  • There are 3 grading systems for warty-basaloid VIN: the traditional 3-grade system of VIN 1-3, a low-grade/high grade Bethesda-like system and the International Society for the Study of Vulvovaginal Disease's proposal for only 1 grade.
  • The ISSVD system eliminates VIN 1 and combines VIN 2 and 3 on the grounds that VIN 1 has not been shown to be a reproducible diagnosis and VIN 2 and 3 are not reliably separated.
  • Warty basaloid VIN may be sub-typed into warty and basaloid VIN.
  • Warty-basaloid VIN may regress.
  • Differentiated VIN has been typically diagnosed co-incident with squamous cell carcinoma.
  • With increased frequency of performance of biopsy of hyperplastic lesions, differentiated VIN should be diagnosed more commonly before squamous carcinoma occurs.
  • [MeSH-major] Carcinoma in Situ / classification. Carcinoma, Squamous Cell / classification. Precancerous Conditions / classification. Terminology as Topic. Vulvar Neoplasms / classification

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  • [CommentIn] J Low Genit Tract Dis. 2006 Jul;10(3):135-6 [16829750.001]
  • (PMID = 16829756.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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15. Valeri RM, Kaplanis K, Apostolou T, Kiziridou A, Pantidou A, Boussoulegas A, Destouni Ch: Basaloid squamous cell carcinoma of the uterine cervix with an uncommon metastasis to the left iliac region--case report. Eur J Gynaecol Oncol; 2006;27(6):625-8
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  • [Title] Basaloid squamous cell carcinoma of the uterine cervix with an uncommon metastasis to the left iliac region--case report.
  • We describe a rare and interesting case of a basaloid squamous cell carcinoma (BSC) of the uterine cervix with metastasis in the left iliac region diagnosed by fine needle aspiration (FNA).
  • The material was processed by conventional liquid based cytology (ThinPrep), and by the cell-block technique and diagnosis was based on the cytomorphologic and immunochemical characteristics as well as the patient's history.
  • The cytologic diagnosis concerned a poorly differentiated squamous cell carcinoma.
  • The histological diagnosis then was an "infiltrative squamous cell carcinoma of basaloid type" of the uterine cervix.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Pelvic Neoplasms / secondary. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasms, Basal Cell / secondary. Neoplasms, Basal Cell / therapy


16. Emanuel P, Wang B, Wu M, Burstein DE: p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol; 2005 May;18(5):645-50
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  • [Title] p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.
  • Morphologic distinction of high-grade adenoid cystic carcinoma from basaloid squamous cell carcinoma can be difficult.
  • We have investigated the possibility that immunohistochemical staining for the presence of p63, a novel epithelial stem-cell regulatory protein, could be a useful means of distinguishing these two neoplasms.
  • Archival, routinely processed slides were subjected to citrate-based antigen retrieval, exposure to anti-p63 monoclonal 4A4, and developed with a streptavidin-biotin kit and diaminobenzidine as chromogen. p63 was detected in 100% of the adenoid cystic carcinomas (n=14) and 100% of basaloid squamous cell carcinomas (n=16).
  • Basaloid squamous cell carcinomas consistently displayed diffuse p63 positivity, with staining of nearly 100% of tumor cells.
  • In contrast, adenoid cystic carcinoma displayed a consistently compartmentalized pattern within tumor nests.
  • (1) selective staining of a single peripheral layer of p63-positive cells surrounding centrally located tumor cells that were p63-negative and (2) tumor nests consisting of multiple contiguous glandular/cribriform-like units of p63-positive cells surrounding or interspersed with p63-negative cells. p63 immunostaining constitutes a specific and accurate means of distinguishing adenoid cystic carcinoma from basaloid squamous cell carcinoma. p63 positivity in adenoid cystic carcinoma appears to be homologous to that seen in the basal and/or myoepithelial compartments of salivary gland and other epithelia, and may signify a stem-cell-like role for these peripheral cells.
  • Diffuse p63 positivity in basaloid squamous cell carcinoma suggests dysregulation of p63-positive stem cells in poorly differentiated squamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Phosphoproteins / analysis. Trans-Activators / analysis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 15529180.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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17. Altrabulsi B, Carrizo F, Luna MA: Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases. Ann Diagn Pathol; 2006 Jun;10(3):149-53
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  • [Title] Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases.
  • We describe the clinicopathological and immunohistochemical features of three spindle (sarcomatoid) basaloid squamous carcinomas in three men aged 73, 69, and 59 years with a history of tobacco and alcohol abuse.
  • Histologically, they were composed of conventional basaloid squamous carcinomas with extensive malignant spindle cell proliferation, comprising more than 50% of the tumor.
  • One case in addition expressed CD99 and Bcl-2 and was originally diagnosed as monophasic synovial sarcoma; however, a subsequent biopsy disclosed basaloid squamous cell carcinoma with sarcomatoid stroma.
  • The patients were alive 14 (case patient 1), 10 (case patient 2), and 8 (case patient 3) months after diagnosis.
  • In the absence of evidence from immunohistochemical or electron microscopy studies, a polypoid malignant spindle cell tumor of a mucosal surface of the upper aerodigestive tract should be considered a sarcomatoid carcinoma until proven otherwise.
  • The type of epithelial component would determine the subtype of sarcomatoid carcinoma.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology. Hypopharynx / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 16730309.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Kacerovska D, Szepe P, Vanecek T, Nemcova J, Michal M, Mukensnabl P, Kazakov DV: Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations. Am J Dermatopathol; 2008 Oct;30(5):472-6
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  • [Title] Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations.
  • The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman.
  • Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes.
  • The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Human papillomavirus 16 / pathogenicity. Rectal Neoplasms / pathology. Skin Neoplasms / pathology. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Mutation / genetics

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  • (PMID = 18806492.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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19. Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA: Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ. Breast J; 2009 Jul-Aug;15(4):409-13
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  • [Title] Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
  • Basaloid carcinomas have been documented in various anatomic locations.
  • We describe a primary invasive adenocarcinoma of the nipple with extensive basaloid features that was also associated with squamous cell carcinoma (SCC) in situ and an aggressive behavior.
  • An excisional specimen showed a 1.7 cm nodule composed of invasive sheets and ribbons of basaloid cells with numerous mitoses, extensive tumor necrosis and evidence of glandular differentiation.
  • The differential diagnosis included a primary basaloid adenocarcinoma of the nipple, basal cell carcinoma of the nipple, neuroendocrine carcinoma, melanoma, basaloid variant of adenoid cystic carcinoma and metastatic disease.
  • Immunohistochemical profile of this tumor supported a primary basaloid adenocarcinoma of the nipple.
  • Although the initial sentinel lymph node biopsy was negative, within a year of diagnosis, the patient developed ipsilateral axillary node and pulmonary metastases.
  • To the best of our knowledge, this is the first case of basaloid carcinoma to be documented in this anatomic site.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Nipples / pathology

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  • (PMID = 19601946.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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20. Wang P, Zhang G, Shen H: Multiple synchronous primary malignancies induced by benzene exposure: a case report. J Occup Med Toxicol; 2009;4:7
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  • 40 years later, this patient developed three synchronous primary neoplasms with three different histologies including a basaloid squamous cell carcinoma of the esophagus, primary hepatocellular carcinoma, and well-differentiated squamous cell carcinoma of the gum.

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  • (PMID = 19371416.001).
  • [ISSN] 1745-6673
  • [Journal-full-title] Journal of occupational medicine and toxicology (London, England)
  • [ISO-abbreviation] J Occup Med Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2674456
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21. Yen TC, Chang JT, Ng SH, Chang YC, Chan SC, Wang HM, See LC, Chen TM, Kang CJ, Wu YF, Lin KJ, Liao CT: Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: comparison with head and neck CT/MRI and histopathology. J Nucl Med; 2005 May;46(5):775-81
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  • [Title] Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: comparison with head and neck CT/MRI and histopathology.
  • This prospective, nonrandomized, case-control study evaluated the impact of (18)F-FDG PET in staging untreated squamous cell carcinoma of the buccal mucosa (BSCC) and compared the results with CT/MRI and histopathology.
  • METHODS: Between January 2002 and April 2004, 102 untreated BSCC patients with cM0 (no evidence of distant metastatic focus on chest radiograph, liver ultrasonograph, and bone scan) were enrolled with either conventional work-up (CWU, n = 51) or PET (CWU+PET, n = 51).
  • RESULTS: Significant benefits of PET compared with those of CT/MRI for BSCC patients were in the detection of locoregional (AUC, 0.973 vs. 0.928; P = 0.026), regional (AUC, 0.939 vs. 0.837; P = 0.026), and level II (AUC, 0.974 vs. 0.717; P = 0.02) lymph nodes.
  • CONCLUSION: The role of (18)F-FDG PET for BSCC with cM0 is limited.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Fluorodeoxyglucose F18. Mouth Mucosa / radionuclide imaging. Mouth Neoplasms / radionuclide imaging. Neoplasm Staging / methods. Positron-Emission Tomography / methods
  • [MeSH-minor] Adult. Case-Control Studies. Female. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / radionuclide imaging. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Prognosis. Prospective Studies. Radiopharmaceuticals. Reproducibility of Results. Sensitivity and Specificity. Tomography, X-Ray Computed / methods

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  • (PMID = 15872350.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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22. Marci V, Volante M, Cappia S, Righi L, Novello C, Scagliotti GV, Brambilla E, Papotti M: Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma. Virchows Arch; 2007 Sep;451(3):729-36
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  • [Title] Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma.
  • The 2004 WHO classification of lung tumours recognised basaloid carcinoma as a variant of squamous and large cell carcinoma.
  • We report a unique case of primary pulmonary adenocarcinoma with a basaloid component.
  • The patient is disease-free 13 months after diagnosis.
  • Histologically, an invasive carcinoma having a glandular and a solid component was observed.
  • The former was an adenocarcinoma with mucus containing spaces lined by columnar mucinous cells and basaloid cells.
  • The solid component was an organoid proliferation of basaloid-type cells, as in cutaneous basal cell carcinoma.
  • Basaloid cells, but not mucinous cells, were immunoreactive for high molecular weight cytokeratins (CK), CK 7 and, focally, for TTF-1.
  • (1) The solid areas resemble a conventional basaloid carcinoma, except for the presence of small mucin-containing spaces. (2) The mucinous adenocarcinoma areas contain two layers of columnar and basaloid cells. (3) Both components are neoplastic based on cell morphology, invasive properties and phenotypic profile.
  • These findings indicate that a basaloid variant of adenocarcinoma is also existing in the spectrum of basaloid carcinomas of the lung.
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell. Humans. Keratins / analysis. Male. Mucins / analysis. Neoplasm Invasiveness. Phenotype. World Health Organization


23. Coletta RD, Almeida OP, Vargas PA: Cytokeratins 1, 7 and 14 immunoexpression are helpful in the diagnosis of basaloid squamous carcinoma. Histopathology; 2006 May;48(6):773-4
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  • [Title] Cytokeratins 1, 7 and 14 immunoexpression are helpful in the diagnosis of basaloid squamous carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Keratins / biosynthesis
  • [MeSH-minor] Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / pathology. Carcinoma, Basosquamous / metabolism. Carcinoma, Basosquamous / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-1. Keratin-14. Keratin-7

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  • (PMID = 16681702.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / KRT1 protein, human; 0 / KRT14 protein, human; 0 / KRT7 protein, human; 0 / Keratin-1; 0 / Keratin-14; 0 / Keratin-7; 68238-35-7 / Keratins
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24. Wadehra V, Johnson SJ: Comments on 'The revised BSCC terminology for abnormal Cervical Cytology'. Cytopathology; 2008 Dec;19(6):400-1
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  • [Title] Comments on 'The revised BSCC terminology for abnormal Cervical Cytology'.


25. Scope A, Mahmood U, Gareau DS, Kenkre M, Lieb JA, Nehal KS, Rajadhyaksha M: In vivo reflectance confocal microscopy of shave biopsy wounds: feasibility of intraoperative mapping of cancer margins. Br J Dermatol; 2010 Dec;163(6):1218-28
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  • BACKGROUND: Reflectance confocal microscopy (RCM) images skin at cellular resolution and has shown utility for the diagnosis of nonmelanoma skin cancer in vivo.
  • Tumour islands of basal cell carcinoma were identified at peripheral or deep dermal margins, correlating on histopathology with aggregates of neoplastic basaloid cells.
  • Atypical cobblestone or honeycomb patterns were identified at the epidermal margins in squamous cell carcinomas, correlating with a proliferation of atypical keratinocytes extending to biopsy margins.
  • [MeSH-major] Biopsy / methods. Carcinoma, Basal Cell / pathology. Microscopy, Confocal / methods. Skin Neoplasms / pathology

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
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  • (PMID = 20874785.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB002715; United States / NIBIB NIH HHS / EB / R01EB002715; United States / NCI NIH HHS / CA / P30 CA008748; United States / NIBIB NIH HHS / EB / R01 EB002715-05; United States / NCI NIH HHS / CA / R44 CA093106
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aluminum Compounds; 0 / Astringents; 0 / Chlorides; 3CYT62D3GA / aluminum chloride
  • [Other-IDs] NLM/ NIHMS237531; NLM/ PMC2988110
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26. Khaldi L, Apostolidis TCh, Pappa DA, Apostolidis MT, Apostolidis TI: Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall. Ann Diagn Pathol; 2006 Oct;10(5):297-300
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  • [Title] Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall.
  • Basaloid squamous carcinoma is a rare variant of squamous cell carcinoma.
  • Histologically, it is identical to basaloid carcinoma at other anatomical sites.
  • Biopsy of the lesion was performed twice, and conventional squamous cell carcinoma was diagnosed; the patient returned 2 months later with progressed metastatic disease.
  • Basaloid squamous carcinoma is a totipotential neoplasm with a grave prognosis.
  • It can be misdiagnosed; therefore, the authors would like to emphasize the significance of this condition in comparison to conventional squamous cell carcinoma, and we provide a review of the relevant recent literature.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Disease Progression. Humans. Immunohistochemistry. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 16979524.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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27. Friedrich RE, Sperber C, Jäkel T, Röser K, Löning T: Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression. Anticancer Res; 2010 May;30(5):1605-12
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  • [Title] Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression.
  • Basaloid squamous cell carcinoma is a variant of squamous cell carcinoma, preferentially arising in the head and neck region.
  • Current reports point to an association of basaloid squamous cell carcinoma (BSCC) and human papilloma virus (HPV) infection.
  • The aim of this study was to analyse the HPV infection status in different entities of oral neoplasms or dysplasias with basaloid differentiation of epithelial cells.
  • MATERIALS AND METHODS: The study comprised data from 34 oral lesions of squamous epithelial origin: 17 BSCCs, 10 papillomas and 7 hyperplasias/dysplasias of oral epithelia.
  • RESULTS: The rate of HPV-infected BSCC was extraordinarily high.
  • The infection status differed significantly between BSCC and other oral lesions in terms of frequency of HPV infection and HPV genotypes. p16 expression proved not to be a suitable surrogate marker of HPV high-risk infection in oral lesions, in particular in BSCC.
  • This was an essential difference of this collective compared to genital carcinomas with HPV high-risk infections.
  • CONCLUSION: This study revealed a high association between BSCC and HPV type 16.
  • Type-specific analysis of HPV infection in head and neck cancer may be important in the differential diagnosis of malignancies in the head and neck region with a basaloid growth pattern.
  • A simplified test for HPV in BSCC of the oral cavity using the immunohistochemical proof of p16 expression as a surrogate marker is non-effective.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / virology. Epithelial Cells / metabolism. Epithelial Cells / virology. Gene Expression Regulation, Viral. Mouth Neoplasms / metabolism. Mouth Neoplasms / virology. Neoplasm Proteins / metabolism. Papillomavirus Infections / metabolism

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  • (PMID = 20592349.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / P16 protein, human
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28. Ghigna MR, Drak Alsibai K, Porras J, Palazzo L, Godchaux JM, Fabre M: Deep-seated rectal/anal basaloid carcinoma: useful immunocytochemistry in rare squamous cell carcinoma variants. Cytopathology; 2009 Oct;20(5):315-20
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  • [Title] Deep-seated rectal/anal basaloid carcinoma: useful immunocytochemistry in rare squamous cell carcinoma variants.
  • OBJECTIVES: To report the cytological aspects of ano-rectal basaloid carcinoma (BC) variant in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) conventional and liquid-based cytology (LBC), in a series of 10 cases of deep-seated squamous cell carcinomas (SCC), and to discuss the diagnostic difficulties in interpreting the morphology and immunocytochemical findings.
  • Of these two cases, only one was correctly diagnosed by EUS-FNA specimen, whereas in the second case, the initial cytological diagnosis was poorly differentiated adenocarcinoma and the final diagnosis of basaloid carcinoma variant was established on surgical resection.
  • Immunocytochemistry (ICC) using CK7, CK20 and CK34betae12 on FNA specimens confirmed the diagnosis retrospectively.
  • CONCLUSION: The diagnosis of basaloid variant of SCC in a rectal location can be very difficult, both on account of the uncommon location and because of the low specificity of morphological aspects on EUS-FNA smears.
  • [MeSH-major] Anus Neoplasms. Carcinoma, Squamous Cell. Immunohistochemistry / methods. Neoplasms, Basal Cell. Rectal Neoplasms

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  • (PMID = 18540877.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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29. Wu C, Herman BA, Retta SM, Grossman LW, Liu JS, Hwang NH: On the closing sounds of a mechanical heart valve. Ann Biomed Eng; 2005 Jun;33(6):743-50
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  • In the present study, the frequency characteristics of the closing sound in air of a Björk-Shiley Convexo-Concave (BSCC) valve are investigated.
  • It is found that for the BSCC valve tested, the distribution of the sound energy over its frequency domain changes at different valve closing speeds, but the cut-off frequency remains unchanged at 123.32 +/- 6.12 kHz.

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  • (PMID = 16078614.001).
  • [ISSN] 0090-6964
  • [Journal-full-title] Annals of biomedical engineering
  • [ISO-abbreviation] Ann Biomed Eng
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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30. Fischer S, Breuninger H, Metzler G, Hoffmann J: Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg; 2005 Jan;16(1):53-8
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  • [Title] Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor.
  • Microcystic adnexal carcinoma (MAC) belongs to the spectrum of locally aggressive adnexal carcinomas and most commonly occurs in the head and neck region.
  • In 1982, Goldstein and colleagues first reported MAC to be a distinct histologic entity characterized by a combination of keratinous cysts in the upper dermis, islands and strands of small basaloid, benign-appearing keratinocytes or squamous cells in the deeper dermis within a dense desmoplastic stroma, and areas of ductular differentiation.
  • The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time.
  • Previous histopathologic diagnoses were squamous cell carcinoma and desmoplastic trichoepithelioma.
  • Local recurrences of the tumor occurred, despite histographic surgery because in hematoxylin and eosin stains, small islands of the deceptively benign-appearing small basaloid cells of MAC were not recognized as tumor cells.
  • The reported case demonstrates the difficulties in diagnosing MAC and indicates that MAC should always be considered in the differential diagnosis of slowly growing tumors in the head and neck region.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Basal Cell / pathology

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  • (PMID = 15699645.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Bekavac-Beslin M, Mijić A, Matejcić A, Ferencić Z: Basaloid squamous cell carcinoma of the esophagus: a case report. Tumori; 2005 Jan-Feb;91(1):87-9
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  • [Title] Basaloid squamous cell carcinoma of the esophagus: a case report.
  • Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma.
  • We present the case of a 48-year-old male patient with esophageal BSCC.
  • In our patient the surgical specimen revealed BSCC with an aggressive pattern (invasion of the whole esophageal wall thickness, lymph node metastases and intraneural spread).
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy

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  • (PMID = 15850013.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Lu SY, Eng HL, Huang CC, Chien CY, Lui CC, Lin JW: Basaloid squamous cell carcinoma of the sinonasal tract: report of two cases. Otolaryngol Head Neck Surg; 2006 May;134(5):883-5
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  • [Title] Basaloid squamous cell carcinoma of the sinonasal tract: report of two cases.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Nose Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Fatal Outcome. Humans. Male

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  • (PMID = 16647553.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Klenzner T, Arapakis I, Kayser G, Boedeker CC: Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma. Otolaryngol Head Neck Surg; 2006 Jul;135(1):158-60
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  • [Title] Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma.
  • [MeSH-major] Acrospiroma / diagnosis. Carcinoma, Basosquamous / diagnosis. Ear, External. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16815204.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Velazquez EF, Melamed J, Barreto JE, Aguero F, Cubilla AL: Sarcomatoid carcinoma of the penis: a clinicopathologic study of 15 cases. Am J Surg Pathol; 2005 Sep;29(9):1152-8
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  • [Title] Sarcomatoid carcinoma of the penis: a clinicopathologic study of 15 cases.
  • Sarcomatoid carcinomas are uncommon, high-grade tumors, predominantly composed of spindle cells.
  • A total of 400 cases of squamous cell carcinoma of the penis were reviewed from which 15 sarcomatoid carcinomas (4%) were identified.
  • Four cases showed a minor mixed component of usual, papillary, verrucous, and basaloid carcinoma.
  • One of the cases was multicentric with a separate independent focus of well-differentiated carcinoma with pseudohyperplastic features.
  • Associated low- and high-grade squamous intraepithelial lesions were noted in 73% of the cases.
  • In conclusion, penile sarcomatoid carcinomas are unusual, large, and aggressive tumors usually associated with lymph node metastasis and poor outcome.
  • Diffuse immunoreactivity for p53, compared with a more basal and focal reactivity in differentiated squamous cell carcinoma, may be indicative of a late mutation in the natural progression of the disease.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged

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  • (PMID = 16096403.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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35. Ordi J, Alejo M, Fusté V, Lloveras B, Del Pino M, Alonso I, Torné A: HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. Am J Surg Pathol; 2009 Nov;33(11):1659-65
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  • [Title] HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN.
  • Histologically, classic VIN may be basaloid and characterized by a replacement of the whole epidermis by a homogeneous population of small, "undifferentiated" keratinocytes, which are diffusely positive for p16(INK4a) and negative for p53.
  • Simplex VIN is frequently associated with squamous cell hyperplasia and lichen sclerosus.
  • From a series of 110 invasive squamous cell carcinomas of the vulva negative for HPV by highly sensitive polymerase chain reaction, 51 had VIN lesions located at least 1 cm away from the tumor.
  • In 4 (7.8%) cases, the VIN had basaloid histologic features.
  • All cases showed obvious architectural disorganization with a homogeneous population of basaloid, undifferentiated keratinocytes with scanty cytoplasm replacing the whole epidermis.
  • Squamous cell hyperplasia was identified in 1 case and lichen sclerosus in 1 case.
  • The invasive squamous cell carcinoma was of keratinizing type in 3 cases and basaloid in 1 case.
  • In conclusion, simplex, HPV-negative VIN may occasionally have basaloid morphology.
  • Immunostaining for p16(INK4a) and p53 protein may be helpful in the identification of these lesions and the differential diagnosis with classic, HPV-positive basaloid VIN.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. DNA, Viral / analysis. Diagnosis, Differential. Female. Humans. Hyperplasia. Lichen Sclerosus et Atrophicus / complications. Lichen Sclerosus et Atrophicus / pathology. Middle Aged. Papillomavirus Infections / diagnosis. Skin / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19730361.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Tumor Suppressor Protein p53
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36. Bhadani PP, Sen R, Bhadani UK, Karki S, Agarwal S: Is fine needle aspiration cytology (FNAC) useful in skin adnexal masses? A study on 5 cases of pilomatixoma. Indian J Pathol Microbiol; 2007 Apr;50(2):411-4
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  • PMX was diagnosed on FNAC in 3 cases on finding groups of basaloid cells, ghost epithelial cells, pink fibrillary material and calcium deposits.
  • Other cases were diagnosed as epidermal inclusion cyst with the differential diagnosis of well differentiated squamous cell carcinoma and skin appendageal tumor of undetermined origin in one case each.
  • [MeSH-major] Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Female. Humans

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  • (PMID = 17883095.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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37. Kimura T, Mukai M, Shiotani A, Moro K, Ikeda A, Okada Y: Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass. Arch Pathol Lab Med; 2005 Apr;129(4):e94-6
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  • [Title] Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass.
  • We report a case of basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component in an 82-year-old man.
  • Histologically, most (70%) of the tumor was composed of malignant spindle cell proliferation, and the rest (30%) was basaloid squamous carcinoma.
  • The preoperative histologic diagnosis was difficult because the endoscopic biopsy specimens showed only spindle cell proliferation.
  • This is an unusual presentation of basaloid squamous carcinoma of the head and neck.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology

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  • (PMID = 15794698.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Kocjan G, Chandra A, Cross P, Denton K, Giles T, Herbert A, Smith P, Remedios D, Wilson P: BSCC Code of Practice--fine needle aspiration cytology. Cytopathology; 2009 Oct;20(5):283-96
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  • [Title] BSCC Code of Practice--fine needle aspiration cytology.
  • Both have been prepared with wide consultation within and outside the BSCC and have been endorsed by the Royal College of Pathologists.
  • This COP provides evidence-based recommendations for setting up FNA services, managing the patients, taking the samples, preparing the slides, collecting material for ancillary tests, providing rapid on-site assessment, classifying the diagnosis and providing a final report.
  • [MeSH-minor] Ambulatory Care Facilities. Bronchoscopy. Endoscopy. Great Britain. Humans. Neoplasms / diagnosis. Neoplasms / pathology. Quality Control. Specimen Handling. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 19754835.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 39
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39. Lee JS, Ko IJ, Jun SY, Kim JY: Basaloid squamous cell carcinoma in nasal cavity. Clin Exp Otorhinolaryngol; 2009 Dec;2(4):207-10
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  • [Title] Basaloid squamous cell carcinoma in nasal cavity.
  • Basaloid squamous cell carcinoma (BSCC) is often founded in the head and neck region.
  • However, BSCC in the sinonasal tract is rare.
  • Histopathologic examination of the excised tumor confirmed BSCC in the nasal cavity.
  • We report here on a nasal cavity BSCC that was treated with partial maxillectomy only.

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  • [Cites] Otolaryngol Head Neck Surg. 2006 May;134(5):883-5 [16647553.001]
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  • (PMID = 20072697.001).
  • [ISSN] 2005-0720
  • [Journal-full-title] Clinical and experimental otorhinolaryngology
  • [ISO-abbreviation] Clin Exp Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2804098
  • [Keywords] NOTNLM ; Basaloid squamous cell carcinoma / Maxillectomy / Sinonasal tract
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40. Li N, Wolgamot G, Argenyi Z: Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma. J Cutan Pathol; 2007 May;34(5):410-4
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  • [Title] Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma.
  • Although primary cutaneous neuroendocrine cell carcinoma [Merkel cell carcinoma (MCC)] may show divergent features, including microcystic ('tubuloglandular'), squamous, eccrine and rhabdomyoblastic, a diffuse microcystic pattern is exceedingly rare.
  • In this study, we present two cases of MCC with prominent microcystic features, which precluded a definitive diagnosis in the initial punch biopsy.
  • Punch biopsies from both patients revealed an infiltrating neoplasm with prominent microcystic features that mimick tubuloglandular structures, lined by hyperchromatic basaloid cells, which were strongly positive for chromogranin and BerEP4, variably positive for CK7 and CK5/6 and negative for CK20, synaptophysin, S-100, epithelial membrane antigen (EMA), gross cystic disease fluid protein-15 (GCDFP-15), estrogen/progesterone receptors (ER/PR), thyroid transcription factor 1 (TTF1) and carcinoembryonic antigen (CEA).
  • Although the lack of CK20 staining is unusual, the histologic characteristics along with the remaining immunohistochemical studies favor the diagnosis of a primary cutaneous neuroendocrine cell carcinoma over the variants of eccrine carcinoma or basal cell carcinoma with neuroendocrine differentiation.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Eccrine Glands / pathology. Humans. Immunohistochemistry. Male. Neck / pathology

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  • (PMID = 17448197.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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41. Morales-Puebla JM, Toro-Rojas M, Segura-Saint-Gerons R, Fanego-Fernández J, López-Villarejo P: Basaloid squamous cell carcinoma: report of five cases. Med Oral Patol Oral Cir Bucal; 2010 May;15(3):e451-5
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  • [Title] Basaloid squamous cell carcinoma: report of five cases.
  • OBJECTIVES: To document the clinical and histopathological characteristics of basaloid squamous cell carcinoma (BSCC).
  • CASES: retrospective review of five cases with the diagnosis of BSCC of the larynx.
  • CONCLUSIONS: BSCC has well defined histological features.
  • Central comedonecrosis within the cells nests, cell with nuclear palisading and high-grade dysplasia in overlaying mucosa are the main characteristics.
  • [MeSH-major] Carcinoma, Squamous Cell. Laryngeal Neoplasms

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  • (PMID = 20038913.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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42. Nagakawa H, Hiroshima K, Takiguchi Y, Yatomi M, Takahashi Y, Mikami M, Nakatani Y, Kuriyama T: Basaloid squamous-cell carcinoma of the lung in a young woman. Int J Clin Oncol; 2006 Feb;11(1):66-8
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  • [Title] Basaloid squamous-cell carcinoma of the lung in a young woman.
  • We report a rare case of basaloid squamous cell carcinoma of the lung in a young Japanese woman.
  • Transbronchial fine-needle aspiration cytology supported a tentative diagnosis of primary squamous-cell carcinoma of the lung.
  • Necropsy established the diagnosis of basaloid squamous-cell carcinoma of the lung.
  • This is the youngest patient with a case of basaloid squamous cell carcinoma of the lung ever reported.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 16508733.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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43. Karatzanis AD, Fragkiadakis GM, Prokopakis EP, Koutsopoulos AV, Helidonis ES, Velegrakis GA: Basaloid squamous cell carcinoma of the soft palate: case report. Auris Nasus Larynx; 2008 Dec;35(4):592-6
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  • [Title] Basaloid squamous cell carcinoma of the soft palate: case report.
  • Basaloid squamous cell carcinoma (BSCC) is a histologically distinct variant of squamous cell carcinoma.
  • The palate is a very rare site of BSCC development and only three cases have been reported in the international literature.
  • In this report, we present a case of basaloid squamous cell carcinoma of the soft palate.
  • The therapeutic strategy and histological findings are described in detail, including immunohistochemistry with the use of involucrin, an agent used for the first time for BSCC diagnosis.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Carcinoma, Squamous Cell / diagnosis. Palatal Neoplasms / diagnosis. Palate, Soft
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Coloring Agents. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Protein Precursors. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 18242906.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Protein Precursors; 60108-77-2 / involucrin
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44. Tilakaratne WM, Kobayashi T, Ida-Yonemochi H, Swelam W, Yamazaki M, Mikami T, Alvarado CG, Shahidul AM, Maruyama S, Cheng J, Saku T: Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers. J Oral Pathol Med; 2009 Apr;38(4):348-55
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  • [Title] Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers.
  • BACKGROUND: As one of the valuable tools for differential diagnoses of oral epithelial dysplasia, carcinoma in situ (CIS) and squamous cell carcinoma (SCC), we have proposed the immunohistochemistry for perlecan, a heparan sulfate proteoglycan (HSPG).
  • The most striking finding was strong expression of MMP-7 in epithelial dysplasia with a two-phase appearance: a clear demarcation of MMP-7-immunopositive (+) lower dysplastic/basaloid cells from non-positive upper keratinized cells.
  • In SCC, MMP-7 positivity was reduced from carcinoma cells but instead appeared in stromal cells.
  • CONCLUSION: These results suggest that the enhanced metabolism of perlecan associated with MMP-7 plays an important role in the cell proliferation of oral epithelia in their malignant transformation process, and that MMP-7 immunohistochemistry may be a valuable aid for identification of the cell proliferation center in oral CIS and dysplasia.
  • [MeSH-major] Carcinoma in Situ / metabolism. Carcinoma, Squamous Cell / metabolism. Cell Transformation, Neoplastic / metabolism. Heparan Sulfate Proteoglycans / metabolism. Matrix Metalloproteinase 7 / biosynthesis. Precancerous Conditions / metabolism. Tongue Neoplasms / metabolism
  • [MeSH-minor] Cell Proliferation. Diagnosis, Differential. Epithelial Cells / metabolism. Epithelial Cells / pathology. Humans. Immunohistochemistry. Matrix Metalloproteinase 1 / biosynthesis. Matrix Metalloproteinase 2 / biosynthesis

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  • (PMID = 19239574.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Heparan Sulfate Proteoglycans; 143972-95-6 / perlecan; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.7 / Matrix Metalloproteinase 1
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45. Kusafuka K, Asano R, Kamijo T, Iida Y, Onitsuka T, Kameya T, Nakajima T: Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis. Int J Oral Maxillofac Surg; 2009 Mar;38(3):296-9
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  • [Title] Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis.
  • A case of large cell neuroendocrine carcinoma (LCNEC) of the tongue base is described.
  • It was characterized by solid tumor nests with central necrosis and rosette formation resembling basaloid squamous cell carcinoma.
  • Basal cells in the normal squamous epithelium around the tumor indicated positivity for neural cell adhesion molecule and N-cadherin.
  • These cells were considered neuroendocrine-related cells in the lingual squamous epithelium, which are related to the tumorigenesis of mucosal LCNEC in the tongue base.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, Neoplasm / immunology. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Immunohistochemistry. Male. Treatment Outcome

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  • (PMID = 19167190.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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46. Serrano MF, El-Mofty SK, Gnepp DR, Lewis JS Jr: Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol; 2008 Apr;39(4):591-8
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  • [Title] Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck.
  • High-grade neuroendocrine carcinomas of the head and neck overlap significantly in morphology with both basaloid squamous and solid-type adenoid cystic carcinomas.
  • High-grade neuroendocrine carcinomas have sheets of small cells with scant cytoplasm, granular chromatin, and inconspicuous nucleoli.
  • Basaloid squamous and adenoid cystic carcinomas are aggressive variants of their respective tumor types which both have nests of basaloid tumor cells with round nuclei, little cytoplasm, and inconspicuous nucleoli.
  • We performed high molecular weight cytokeratin (CK) and p63 immunohistochemistry on 19 neuroendocrine carcinomas, 18 basaloid squamous carcinomas, and 11 solid-type adenoid cystic carcinomas.
  • All basaloid squamous and adenoid cystic carcinomas were positive for CK 5/6 and 34betaE12.
  • Only 4 and 5 of the 19 neuroendocrine carcinomas, respectively, were positive for these markers.
  • Staining was focal in the neuroendocrine cases when positive, whereas almost all basaloid squamous and adenoid cystic carcinomas showed strong staining.
  • Almost all tumors of each type were positive for p63, including neuroendocrine carcinomas, but with different staining patterns.
  • Basaloid squamous carcinomas were diffusely positive, neuroendocrine carcinomas were diffusely positive, but with weak staining, and adenoid cystic carcinomas showed a distinct pattern with staining at the periphery of the cell nests only.
  • We conclude that high molecular weight cytokeratin immunostaining is helpful in distinguishing high-grade neuroendocrine carcinomas from similar tumor types.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basosquamous / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Head and Neck Neoplasms / diagnosis. Keratins / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-5 / analysis. Keratin-6 / analysis. Male. Membrane Proteins / analysis. Middle Aged. Molecular Weight


47. Lantuéjoul S, Salameire D, Salon C, Brambilla E: Pulmonary preneoplasia--sequential molecular carcinogenetic events. Histopathology; 2009 Jan;54(1):43-54
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  • The three pulmonary preneoplastic changes recognized to date in the lung include bronchial squamous dysplasia and in situ carcinoma, preceding invasive squamous cell carcinoma and basaloid carcinoma, atypical adenomatous hyperplasia, a preneoplastic condition of bronchioloalveolar carcinoma, and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, a proposed precursor for carcinoid tumours.
  • [MeSH-minor] Adenocarcinoma / pathology. Humans. Lung / pathology. Small Cell Lung Carcinoma / pathology

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  • (PMID = 19187179.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 90
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48. Ball NJ, Tanhuanco-Kho G: Merkel cell carcinoma frequently shows histologic features of basal cell carcinoma: a study of 30 cases. J Cutan Pathol; 2007 Aug;34(8):612-9
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  • [Title] Merkel cell carcinoma frequently shows histologic features of basal cell carcinoma: a study of 30 cases.
  • BACKGROUND: Merkel cell carcinoma (MCC) is a basaloid cutaneous neoplasm that may be mistaken for basal cell carcinoma (BCC).
  • Squamous cell carcinoma was identified in four cases (13%).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Merkel Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers. Biopsy. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • [CommentIn] J Cutan Pathol. 2008 Aug;35(8):789-90 [18687075.001]
  • (PMID = 17640231.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers
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49. Akagi I, Miyashita M, Makino H, Nomura T, Ohkawa K, Tajiri T: Basaloid squamous cell carcinoma of the esophagus: report of two cases. J Nippon Med Sch; 2008 Dec;75(6):354-60
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  • [Title] Basaloid squamous cell carcinoma of the esophagus: report of two cases.
  • Basaloid squamous cell carcinoma is an uncommon malignancy of the esophagus.
  • We present two cases of basaloid squamous carcinoma of the esophagus.
  • Both tumors histologically consisted of solid cell nests and displayed focal immunoreactivity for type IV collagen.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Esophageal Neoplasms / pathology

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  • (PMID = 19155575.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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50. Thariat J, Ahamad A, El-Naggar AK, Williams MD, Holsinger FC, Glisson BS, Allen PK, Morrison WH, Weber RS, Ang KK, Garden AS: Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck: a case-control study. Cancer; 2008 Jun 15;112(12):2698-709
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  • [Title] Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck: a case-control study.
  • BACKGROUND: Basaloid squamous cell carcinoma (BSCC) is an uncommon, high-grade variant of squamous cell carcinoma (SCC) of the head and neck.
  • The authors investigated the outcomes of patients with BSCC who received radiotherapy and compared them with the outcomes of patients with SCC.
  • METHODS: From 1994 to 2004, 1007 patients received radiotherapy for head and neck carcinoma with lymph node involvement.
  • The histologic types consisted of 51 BSCC, 431 poorly differentiated SCC (PSCC), and 525 well or moderately differentiated SCC (WMSCC).
  • A case-control analysis was performed with BSCC matched against both PSCC and WMSCC to compare disease-control and survival rates.
  • RESULTS: Patients with BSCC received treatment modalities similar to those received by patients with SCC: They received induction chemotherapy (12%) or concurrent chemotherapy (33%), and a median radiation dose of 70 Gray.
  • Posttreatment viable tumor was present in 44%, 13%, and 28% of neck dissection specimens from patients with BSCC, PSCC, and WMSCC, respectively.
  • The 5-year disease-free survival rates (63%, 77%, and 76%, respectively) and overall survival rates (85%, 70%, and 71%, respectively) demonstrated no statistically significant differences for BSCC, PSCC, or WMSCC, respectively.
  • CONCLUSIONS: In this study, a poorer prognosis could not be demonstrated for irradiated patients with BSCC compared with either PSCC or WMSCC.
  • The BSCC cohort did have a relatively high rate of viable tumor in their posttreatment neck dissections, and they had a relatively high rate of distant disease.
  • [MeSH-major] Carcinoma, Basosquamous / radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Head and Neck Neoplasms / radiotherapy

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  • [Copyright] Copyright (c) 2008 American Cancer Society.
  • (PMID = 18429002.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA06294
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Chen JX, Tang Q, Zhu HN, Zheng YD: [Diagnosis and treatment of basaloid squamous cell carcinoma of the esophagus]. Zhonghua Zhong Liu Za Zhi; 2008 May;30(5):392-5
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  • [Title] [Diagnosis and treatment of basaloid squamous cell carcinoma of the esophagus].
  • OBJECTIVE: To investigate the histopathological features of basaloid squamous cell carcinoma of the esophagus, and to explore the ways of its diagnosis, differential diagnosis and treatment.
  • METHODS: The clinical data and pathological features of 23 cases of esophageal basaloid squamous cell carcinoma were reviewed and analyzed retrospectively.
  • CONCLUSION: The basaloid squamous cell carcinoma of the esophagus is highly malignant with poor prognosis.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Carcinoma, Basosquamous / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy. Esophagus / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / diagnosis. Cisplatin / administration & dosage. Combined Modality Therapy. Diagnosis, Differential. Esophagectomy / methods. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Middle Aged. Radiotherapy, High-Energy. Retrospective Studies. Survival Rate

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  • (PMID = 18953844.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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52. Díaz de Liaño A, Olivera E, Yárnoz C, García-Bragado F, Ortiz H: [Multifocal basaloid squamous carcinoma of the esophagus]. Cir Esp; 2007 Dec;82(6):358-60
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  • [Title] [Multifocal basaloid squamous carcinoma of the esophagus].
  • [Transliterated title] Carcinoma basaloide escamoso multifocal de esófago.
  • Basaloid-squamous carcinoma is a poorly-differentiated variety of squamous cell carcinoma.
  • We present a case of basaloid-squamous cell of the esophagus a 54 year-old man who underwent an esophagectomy with lymphadenectomy and has been followed-up for 5 years with no evidence of disease recurrence.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology

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  • (PMID = 18053506.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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53. Liao CT, Huang SF, Chen IH, Chang JT, Wang HM, Ng SH, Hsueh C, Lee LY, Lin CH, Cheng AJ, Yen TC: When does skin excision allow the achievement of an adequate local control rate in patients with squamous cell carcinoma involving the buccal mucosa? Ann Surg Oncol; 2008 Aug;15(8):2187-94
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  • [Title] When does skin excision allow the achievement of an adequate local control rate in patients with squamous cell carcinoma involving the buccal mucosa?
  • BACKGROUND: The role of cheek skin excision in patients with squamous cell carcinoma of the buccal mucosa (BSCC) remains controversial.
  • METHODS: A total of 331 patients with BSCC were reviewed.
  • CONCLUSION: In patients with BSCC, a good 5-year local control rate may be equally achieved either with or without skin excision.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Mucosa / surgery. Mouth Neoplasms / surgery. Neoplasm Recurrence, Local

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  • (PMID = 18506533.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Campos MS, Modolo F, de Oliveira JS, Pinto-Júnior DS, de Sousa SC: Atypical presentation of oral basaloid squamous cell carcinoma. J Contemp Dent Pract; 2009;10(2):98-104
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  • [Title] Atypical presentation of oral basaloid squamous cell carcinoma.
  • AIM: The purpose of this report is to present the clinical and histological features of a basaloid squamous cell carcinoma (BSCC) occurring in the retromolar trigone of a 59-year-old man and to relate its immunohistochemical characteristics.
  • BACKGROUND: BSCC is an aggressive distinct variant of squamous cell carcinoma (SCC) requiring recognition as a separate entity from SCC due to its peculiar behavior.
  • Histologically, nests and cords of closely packed, moderately pleomorphic basaloid cells with nuclear palisading along the periphery of the neoplastic nests surrounded by a fibrous stroma were found.
  • SUMMARY: Since this tumor can mimic other neoplasms such as adenoid cystic carcinoma, neuroendocrine carcinoma, and basal cell adenocarcinoma, histological features are essential to differentiate between them.
  • CLINICAL SIGNIFICANCE: BSCC needs to be differentiated from other neoplasms as early as possible because of its adverse prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Transitional Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Cell Nucleus / ultrastructure. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Keratins / analysis. Ki-67 Antigen / analysis. Laminin / analysis. Male. Middle Aged. Mitosis. Necrosis. Tumor Suppressor Protein p53 / analysis


55. Sonegawa H, Nukui T, Li DW, Takaishi M, Sakaguchi M, Huh NH: Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression. J Mol Med (Berl); 2007 Jul;85(7):753-62
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  • [Title] Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression.
  • In the present study, we examined the possible deterioration in the pathway in human squamous cancer cell lines, focusing on intracellular localization of S100C/A11 and its functional partners Smad3 and Smad4.
  • All four human squamous cancer cell lines examined (A431, BSCC-93, DJM-1, and HSC-5) were resistant to growth suppression by TGFbeta.
  • In BSCC-93, DJM-1, and HSC-5 cells exposed to TGFbeta, S100C/A11 was not transferred to the nuclei, and p21(WAF1) was not induced.
  • These results indicate that the deterioration in the S100C/A11-mediated pathway conferred upon the cancer cell lines resistance to TGFbeta.
  • Thus, the newly found S100C/A11-mediated pathway is at least partly involved in conferring upon human squamous cell cancers resistant to TGFbeta-induced growth suppression, which is considered to play a critical role for the initiation and progression of many human cancers.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Division / drug effects. Drug Resistance, Neoplasm / drug effects. Smad3 Protein / metabolism. Smad4 Protein / metabolism. Transforming Growth Factor beta / pharmacology
  • [MeSH-minor] Cell Line, Tumor. Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p21 / genetics. Gene Expression Regulation / drug effects. Humans. Protein Transport. Signal Transduction

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  • (PMID = 17476473.001).
  • [ISSN] 0946-2716
  • [Journal-full-title] Journal of molecular medicine (Berlin, Germany)
  • [ISO-abbreviation] J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / SMAD3 protein, human; 0 / SMAD4 protein, human; 0 / Smad3 Protein; 0 / Smad4 Protein; 0 / Transforming Growth Factor beta
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56. Pereira MC, Oliveira DT, Landman G, Kowalski LP: Histologic subtypes of oral squamous cell carcinoma: prognostic relevance. J Can Dent Assoc; 2007 May;73(4):339-44
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  • [Title] Histologic subtypes of oral squamous cell carcinoma: prognostic relevance.
  • Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity.
  • The conventional tumour and several histologic subtypes of SCC present morphologic features and specific behaviour when they occur in the oral mucosa.
  • For example, basaloid SCC is an aggressive tumour and verrucous carcinoma has the lowest invasive and metastatic potential; however, the clinical and biologic course of these oral SCC variants has not been completely established.
  • The purpose of this article is to review the various subtypes of oral SCC, emphasizing problems in their histologic diagnosis and prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basosquamous / pathology. Carcinoma, Verrucous / pathology. Humans. Prognosis


57. Chapman-Fredricks J, Jorda M, Gomez-Fernandez C: A limited immunohistochemical panel helps differentiate small cell epithelial malignancies of the sinonasal cavity and nasopharynx. Appl Immunohistochem Mol Morphol; 2009 May;17(3):207-10
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  • [Title] A limited immunohistochemical panel helps differentiate small cell epithelial malignancies of the sinonasal cavity and nasopharynx.
  • BACKGROUND: Distinguishing small cell epithelial malignancies of the sinonasal cavity and nasopharynx is difficult due to overlapping morphologic characteristics, particularly in small biopsies.
  • The aim of this study is to identify a limited immunohistochemical panel that may help to differentiate these morphologically similar small cell epithelial malignancies.
  • DESIGN: We reviewed 37 cases of histologically similar small cell epithelial malignancies of the sinonasal cavity and nasopharynx: nasopharyngeal carcinoma (NPC) (16), basaloid squamous cell carcinoma (BSCC) (15), and high-grade neuroendocrine carcinoma (HGNEC) (6) obtained at Jackson Memorial Hospital/UM Sylvester Comprehensive Cancer Center between 2003 and 2007.
  • Immunohistochemistry for HLA-DR was positive in all cases of NPC, whereas BSCC and HGNEC were uniformly negative.
  • Cases of NPC and BSCC were positive for CK5/6 whereas cases of HGNEC were negative.
  • CONCLUSIONS: A limited immunohistochemical panel of CK, CK5/6, p63, and HLA-DR is useful in discriminating nasopharyngeal, basaloid squamous cell, and high-grade neuroendocrine carcinomas of the sinonasal cavity and nasopharynx.

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  • (PMID = 19077909.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / HLA-DR Antigens; 0 / Keratin-5; 0 / Keratin-6; 0 / Membrane Proteins
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58. Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA: Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis. J Clin Pathol; 2010 Oct;63(10):857-66
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  • [Title] Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
  • Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma (SCC) of the head and neck.
  • Wain's criteria (peripheral palisading, association with SCC, high nuclear-cytoplasmic ratio, high mitotic rate, solid growth), anti-34BE12 and CK 5/6 staining, and absence of neuroendocrine markers are mandatory for the diagnosis of BSCC.
  • On the other hand, BSCC is frequently considered a high-grade carcinoma of poorer prognosis than its SCC counterparts, mostly due to a higher rate of distant metastases.
  • However, BSCC has similar or better locoregional control rates and a relatively better radiosensitivity than SCC.
  • BSCC seems to have a dual behaviour depending, at least partly, on its recently described association with HPV.
  • The basaloid subtype of SCC, owing to its particular behaviour, should be systematically investigated along with HPV and smoking status, as those factors may be determinant in the response to treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Head and Neck Neoplasms / virology. Papillomavirus Infections / complications
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Combined Modality Therapy. Diagnosis, Differential. Humans. Prognosis


59. Denton K: The proposed BSCC terminology for abnormal cervical cytology. Cytopathology; 2008 Dec;19(6):398-9
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  • [Title] The proposed BSCC terminology for abnormal cervical cytology.


60. Zhang S, Bao R, Bagby J, Abreo F: Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol; 2009 Jul-Aug;53(4):375-82
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  • There were 5 false negatives: 2 adenoid cystic carcinomas, 1 acinic cell carcinoma, 1 polymorphous low grade adenocarcinoma and 1 metastatic basaloid squamous cell carcinoma.
  • The only false positive was a pleomorphic adenoma misdiagnosed as adenoid cystic carcinoma.
  • CONCLUSION: Our results are consistent with the literature that salivary gland FNA has good sensitivity, specificity and accuracy in the diagnosis of salivary neoplasms.

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  • (PMID = 19697720.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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61. Rekhi B, Kane SV, Chaturvedi P: Cytomorphology of a metastatic basaloid squamous carcinoma from an intranasal tumor: a diagnostic mimic for a neuroendocrine tumor--a rare case report. Diagn Cytopathol; 2009 Jul;37(7):546-8
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  • [Title] Cytomorphology of a metastatic basaloid squamous carcinoma from an intranasal tumor: a diagnostic mimic for a neuroendocrine tumor--a rare case report.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Neuroendocrine / pathology. Carcinoma, Squamous Cell / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Cytodiagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Metastasis. Neuroblastoma / pathology

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  • (PMID = 19373914.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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62. Chandra A, Cross P, Denton K, Giles T, Hemming D, Payne C, Wilson A, Wilson P: The BSCC code of practice--exfoliative cytopathology (excluding gynaecological cytopathology). Cytopathology; 2009 Aug;20(4):211-23
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  • [Title] The BSCC code of practice--exfoliative cytopathology (excluding gynaecological cytopathology).
  • It clearly has a role in the diagnosis of neoplastic disease but its role in establishing non-neoplastic diagnoses should also be recognised.
  • Ancillary tests may be required to establish a definitive diagnosis.

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  • (PMID = 19659955.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 23
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63. Stelow EB, Mills SE: Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol; 2005 Dec;124 Suppl:S96-109
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  • [Title] Squamous cell carcinoma variants of the upper aerodigestive tract.
  • Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract.
  • In such cases, correct diagnosis is important for prognostic and therapeutic reasons.
  • This article discusses the clinicopathologic features of the upper aerodigestive tract variants of SCC, including verrucous carcinoma, papillary squamous cell carcinoma, basaloid squamous cell carcinoma, spindle cell carcinoma, adenosquamous carcinoma, adenoid squamous cell carcinoma, and undifferentiated carcinoma.
  • It also discusses the differential diagnoses that must be considered and the use of ancillary testing, especially immunohistochemical analysis, for determining the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Digestive System Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Papillary / pathology. Humans

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  • (PMID = 16468420.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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64. Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL: Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature. Am J Surg Pathol; 2010 Mar;34(3):385-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
  • From the pathogenic point of view, penile cancers may be grouped in human papillomavirus-related and unrelated tumors, each one of them with distinctive morphologic features.
  • The former are predominantly composed of small, undifferentiated basaloid cells, with more or less prominent koilocytic changes, and the latter of keratinizing differentiated squamous cells.
  • On the basis of these observations, we constructed a novel nomenclature for penile precancerous lesions and classified them as penile intraepithelial neoplasia (PeIN) of differentiated, warty, basaloid, and warty-basaloid types.
  • Distribution of PeIN types was: differentiated, 72%; basaloid, 9%; warty-basaloid, 7%; warty, 4%; and mixed, 7%.
  • There was a striking similarity in the morphology of in situ and invasive squamous cell carcinomas.
  • Differentiated PeIN was commonly associated with usual, verrucous, papillary, and other low-grade keratinizing variants of squamous cell carcinoma whereas in basaloid and warty carcinomas the presence of in situ lesions with similar morphology was habitual.
  • To properly distinguish differentiated PeIN from in situ lesions with warty and/or basaloid features only pattern 3, which requires full-thickness staining in all epithelial cells, was considered positive.
  • Using this approach, there was a significant association of the negative patterns and differentiated PeIN and of the positive pattern and warty, basaloid, and warty-basaloid PeIN (P<0.0001).
  • Basaloid variant had the strongest association.
  • Although more studies are necessary to confirm these observations, p16 overexpression seems to be a useful tool for discriminating differentiated from warty, basaloid, and warty-basaloid PeIN.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma in Situ / classification. Carcinoma, Squamous Cell / classification. Condylomata Acuminata / classification. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Papillomavirus Infections / classification. Penile Neoplasms / classification. Precancerous Conditions / classification. Terminology as Topic
  • [MeSH-minor] Cell Differentiation. Diagnosis, Differential. Humans. Immunohistochemistry. Lichen Sclerosus et Atrophicus / classification. Lichen Sclerosus et Atrophicus / metabolism. Male. Neoplasm Invasiveness. Predictive Value of Tests. Sensitivity and Specificity. Up-Regulation

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  • (PMID = 20139761.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
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65. Szentirmay Z, Pólus K, Tamás L, Szentkuti G, Kurcsics J, Csernák E, Tóth E, Kásler M: Human papillomavirus in head and neck cancer: molecular biology and clinicopathological correlations. Cancer Metastasis Rev; 2005 Jan;24(1):19-34
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  • Among the HPV types infecting the mucosa, high-risk, intermediate-risk and low-risk genotypes are defined, depending on their presence in carcinoma or precursor lesions.
  • The groups A6, A7, and A9 include viruses that are frequently demonstrated in basaloid and verrucosus squamous cell carcinomas known to associate with HPV infection.
  • Integration of HPV DNA into the host cell genome occurs early in cancer development and is an important event in malignant transformation.
  • In the Kaplan-Meier survival model, the HPV-positive verrucous and basaloid squamous cell carcinomas showed better survival rates than the HPV-negative typical squamous cell carcinomas.
  • An increased radiocurability of HPV-positive head and neck squamous cell carcinoma (HNSCC) has also been demonstrated.
  • [MeSH-minor] Animals. Cell Transformation, Neoplastic. Genome, Viral. Humans. Phylogeny

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  • (PMID = 15785870.001).
  • [ISSN] 0167-7659
  • [Journal-full-title] Cancer metastasis reviews
  • [ISO-abbreviation] Cancer Metastasis Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 110
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66. Antoine M: [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment]. Rev Pneumol Clin; 2007 Jun;63(3):183-92
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  • [Title] [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment].
  • We detail here the contribution of IHC to the classification of lung cancer: small-cell lung cancer and other neuroendocrine tumors, basaloid carcinoma, large-cell carcinoma.
  • The distinction is less clear for large-cell carcinoma or squamous-cell carcinoma, or for tumors with a pleural or mediastinal presentation.
  • IHC is also useful as a diagnostic aid for rare entities: carcinomas with an unusual morphology (alpha-fetoproetin secretors or beta-HCG secretors), melanomas, lymphomas, sarcomas.
  • Other morphological techniques such as hybridization in situ or molecular biology techniques will further complete the histological diagnosis in the future.
  • [MeSH-minor] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carcinoma, Large Cell / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / pathology. Chorionic Gonadotropin, beta Subunit, Human / analysis. Forecasting. Humans. Lymph Nodes / pathology. Lymphoma / pathology. Mediastinal Neoplasms / pathology. Melanoma / pathology. Neoplasm Staging. Neuroendocrine Tumors / pathology. Pleural Neoplasms / pathology. Prognosis. Sarcoma / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 17675942.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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67. Thariat J, Cecille B, Claire F, Pierre-yves M, Adrien RC: Human papillomavirus-positive basaloid squamous cell carcinomas of the head and neck. Hum Pathol; 2010 Oct;41(10):1505-6; author reply 1506
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  • [Title] Human papillomavirus-positive basaloid squamous cell carcinomas of the head and neck.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Hypopharyngeal Neoplasms / virology. Laryngeal Neoplasms / virology. Oropharyngeal Neoplasms / virology. Papillomaviridae / isolation & purification

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  • [CommentOn] Hum Pathol. 2010 Jul;41(7):1016-23 [20236687.001]
  • (PMID = 20868902.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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68. Ali F, Brown A, Gottwald L, Thomas J: Basal cell carcinoma with matrical differentiation in a transplant patient: a case report and review of the literature. J Cutan Pathol; 2005 Jul;32(6):445-8
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  • [Title] Basal cell carcinoma with matrical differentiation in a transplant patient: a case report and review of the literature.
  • BACKGROUND: Shadow cells, characterized by basaloid squamous cells with a distinct well-defined border and a central unstained area as a shadow of lost nuclei, are characteristic of pilomatricoma, a distinct neoplasm of hair matrix differentiation.
  • The presence of shadow cells within tumor islands composed of follicular germinative cells of an otherwise classic basal cell carcinoma (BCC) has been considered as a distinct diagnostic category of BCC with matrical differentiation.
  • RESULTS: The H&E-stained sections of the hand lesion revealed multiple nodular masses of basaloid follicular germinative cells.
  • Elsewhere, the majority of the tumor contained a population of shadow cells, similar to those in pilomatricoma, with basaloid-appearing matrical cells in the periphery.
  • Trichohyaline granules were identified in the cytoplasm of many of the peripheral basaloid cells.
  • [MeSH-major] Carcinoma, Basal Cell / immunology. Carcinoma, Basal Cell / pathology. Heart Transplantation. Immunocompromised Host. Skin Neoplasms / immunology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Hair Diseases / pathology. Hand / pathology. Humans. Male. Middle Aged. Pilomatrixoma / pathology

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  • (PMID = 15953381.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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69. Záruba K, Králová J, Rezanka P, Poucková P, Veverková L, Král V: Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy. Org Biomol Chem; 2010 Jul 21;8(14):3202-6
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  • Two porphyrin-brucine quaternary ammonium salts were immobilized on gold nanoparticles and their suitability for both in vitro and in vivo photodynamic therapy (PDT) was assayed using the basaloid squamous cell carcinoma PE/CA-PJ34 cell line.
  • [MeSH-minor] Alkylation. Animals. Biological Transport. Cell Death / drug effects. Cell Death / radiation effects. Cell Line, Tumor. Humans. Intracellular Space / metabolism. Mice. Neoplasms / drug therapy. Solvents / chemistry

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  • (PMID = 20485822.001).
  • [ISSN] 1477-0539
  • [Journal-full-title] Organic & biomolecular chemistry
  • [ISO-abbreviation] Org. Biomol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Porphyrins; 0 / Solvents; 6NG17YCK6H / brucine; 7440-57-5 / Gold; H9Y79VD43J / Strychnine
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70. Slater DN, Rice S, Stewart R, Melling SE, Hewer EM, Smith JH: Proposed Sheffield quantitative criteria in cervical cytology to assist the diagnosis and grading of squamous intra-epithelial lesions, as some Bethesda system definitions require amendment. Cytopathology; 2005 Aug;16(4):168-78
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  • [Title] Proposed Sheffield quantitative criteria in cervical cytology to assist the diagnosis and grading of squamous intra-epithelial lesions, as some Bethesda system definitions require amendment.
  • OBJECTIVE: This study assesses the accuracy of published quantitative and qualitative criteria in the Bethesda System (TBS) for squamous intra-epithelial lesions.
  • Comparisons were also made with the British Society for Clinical Cytology (BSCC) terminology in cervical cytology, using the illustrations in their terminology publication and amalgamating the results into their proposed new two-tier model.
  • RESULTS: TBS quantitatively defines low-grade squamous intra-epithelial lesions (LSIL) in both conventional and liquid-based cytology (LBC) preparations as showing nuclear enlargement more than x3 the area of a normal intermediate squamous cell nucleus.
  • This study identified a progressive and statistically significant reduction in mean cytoplasmic area from normal intermediate cells to LSIL and then to high-grade squamous intra-epithelial lesions (HSIL) in both conventional and LBC preparations.
  • In addition, the proposed new BSCC low and high grades of squamous abnormality were not statistically different from ASC-US/LSIL and HSIL, respectively.
  • This provides support that the proposed BSCC two-tier system of squamous abnormalities is comparable to TBS.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Cytodiagnosis / standards. Terminology as Topic. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Cell Nucleus Structures / pathology. Cell Nucleus Structures / ultrastructure. Female. Humans. Image Cytometry / standards


71. Herbert DA: Terms without borders: an international approach to terminology. Diagn Cytopathol; 2005 Nov;33(5):352-5
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  • In particular, the new terminology proposed by the British Society for Clinical Cytology (BSCC) is closely aligned with the Bethesda system (TBS) as modified in 2001.
  • [MeSH-major] Carcinoma in Situ / classification. Cervical Intraepithelial Neoplasia / classification. Cervix Uteri / pathology. Epithelial Cells / pathology. Terminology as Topic. Uterine Cervical Dysplasia / classification. Uterine Cervical Neoplasms / classification


72. Chaux A, Soares F, Rodríguez I, Barreto J, Lezcano C, Torres J, Velazquez EF, Cubilla AL: Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases. Am J Surg Pathol; 2010 Feb;34(2):223-30
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  • [Title] Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases.
  • There is a group of low-grade papillomatous squamous cell carcinomas (SCC) of the penis, collectively designated as "verruciform," that are difficult to classify.
  • A proposal of classification grouped these tumors in warty (condylomatous), verrucous, and papillary carcinomas.
  • Papillary carcinomas were large (mean 5.6 cm) exophytic low-grade squamous neoplasms with hyperkeratosis and papillomatosis.
  • Frequent associated lesions were squamous hyperplasia, differentiated penile intraepithelial neoplasia, and lichen sclerosus (74%, 46%, and 34%, respectively).
  • In conclusion, papillary carcinomas were exophytic albeit, often deeply invasive low-grade neoplasms, with a low rate of nodal metastasis characterized by complex papillae, irregular fibrovascular cores, and jagged tumor base.
  • Papillary SCC should be distinguished from other penile verruciform tumors, including verrucous and variants, warty and papillary basaloid carcinomas, and carcinoma cuniculatum.
  • Helpful morphologic features for differential diagnosis are provided.
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Verrucous / pathology. Penile Neoplasms / pathology

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  • (PMID = 20061934.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Jani P, Chetty R, Ghazarian DM: An unusual composite pilomatrix carcinoma with intralesional melanocytes: differential diagnosis, immunohistochemical evaluation, and review of the literature. Am J Dermatopathol; 2008 Apr;30(2):174-7
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  • [Title] An unusual composite pilomatrix carcinoma with intralesional melanocytes: differential diagnosis, immunohistochemical evaluation, and review of the literature.
  • We report a case of an extremely rare histologic combination of pilomatrix or pilomatrical carcinoma with admixed melanocytes within the same tumor mass.
  • Pilomatrix carcinoma is a neoplasm of low-grade malignancy that is characterized by a tendency for recurrence but low risk of metastasis.
  • Histologically, it was typified by asymmetry and poor circumscription, the presence of several variably sized and shaped basaloid aggregations, and surface ulceration.
  • The tumors were composed of pleomorphic basaloid cells with prominent nucleoli and frequent mitoses (some of which were atypical) accompanied by central areas with keratotic material, shadow cells, and foci of necrosis.
  • In addition, intermingled with the pilomatrix carcinoma, several easily identified pigmented cells with dendritic processes were present singly and as small aggregates.
  • Immunohistochemistry revealed the CK14 to be positive mainly within the keratinizing and the squamous epithelial elements of the tumor.
  • Pilomatrix carcinoma with melanocytes should be distinguished from the conventional pilomatrixoma with pigmentation, melanocytic matricoma, melanoma, and pigmented basal cell carcinoma with matrical differentiation.
  • Clinicians and pathologists should be aware of the occurrence of pilomatrix carcinoma with melanocytes because of its potential for diagnosis as melanoma.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Hair Diseases / pathology. Melanocytes / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Nose. Risk Assessment. Treatment Outcome

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  • (PMID = 18360125.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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74. Soriano E, Faure C, Lantuejoul S, Reyt E, Bolla M, Brambilla E, Righini CA: Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case-control study of 62 patients. Eur J Cancer; 2008 Jan;44(2):244-50
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  • [Title] Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case-control study of 62 patients.
  • OBJECTIVE: To describe the natural history and evaluate the prognosis of basaloid squamous cell carcinoma (BSCC) of the upper aero-digestive tract as compared to the usual squamous cell carcinoma (SCC).
  • MATERIALS AND METHODS: Sixty-two patients with BSCC and 62 patients with SCC were matched with regards to TNM classification, localisation and therapeutic modalities.
  • RESULTS: Survival rates were significantly higher in patients with SCC as compared to patients with BSCC.
  • The rate of distant metastasis was six times higher in cases of BSCC, which was the major cause of mortality.
  • CONCLUSION: This study reveals that BSCC has distinct histo-pathologic features and an aggressive clinical course, justifying its consideration as a separate entity with poor prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Head and Neck Neoplasms / mortality


75. Ota Y, Aoki T, Karakida K, Otsuru M, Kurabayashi H, Sasaki M, Nakamura N, Kajiwara H: Determination of deep surgical margin based on anatomical architecture for local control of squamous cell carcinoma of the buccal mucosa. Oral Oncol; 2009 Jul;45(7):605-9
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  • [Title] Determination of deep surgical margin based on anatomical architecture for local control of squamous cell carcinoma of the buccal mucosa.
  • Of all oral squamous cell carcinomas, squamous cell carcinomas of the buccal mucosa (BSCC) are most associated with poorest prognosis.
  • This is considered to result from the surgeon's determination of the deep surgical margin for resection based on palpation alone when performing BSCC surgery.
  • Therefore, an objective system for classifying the depth of invasion of a tumor appears to be necessary in order to improve the results of BSCC treatment.
  • The disease-specific survival rate of BSCC when treated based on our classification was 73.7% and the local control rate was 89.5%.
  • [MeSH-major] Carcinoma, Squamous Cell / ultrasonography. Mouth Mucosa / ultrasonography. Mouth Neoplasms / ultrasonography


76. Denton KJ, Herbert A, Turnbull LS, Waddell C, Desai MS, Rana DN, Dudding N, Smith JH, British Society of Clinical Cytology: The revised BSCC terminology for abnormal cervical cytology. Cytopathology; 2008 Jun;19(3):137-57
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  • [Title] The revised BSCC terminology for abnormal cervical cytology.
  • The BSCC terminology was originally published in 1986 and although highly successful, requires revision.
  • Through a process of professional consensus and literature review this has been undertaken by the BSCC.

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  • [CommentIn] Cytopathology. 2008 Dec;19(6):398-9 [19040547.001]
  • [CommentIn] Cytopathology. 2008 Dec;19(6):400-1 [19040549.001]
  • [CommentIn] Cytopathology. 2008 Dec;19(6):399-400 [19040548.001]
  • (PMID = 18494998.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] England
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77. Cabanillas R, Rodrigo JP, Ferlito A, Rinaldo A, Fresno MF, Aguilar C, Alvarez ME, Suárez C: Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx? Oral Oncol; 2007 Apr;43(4):327-32
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  • [Title] Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx?
  • The epidemiological link between human papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied.
  • The tobacco and alcohol consumption and the clinical outcomes of nine patients with BSCC of the pharynx are compared with site and stage matched 109 conventional squamous cell carcinoma (SCC) patients.
  • The BSCC specimens were analyzed for the presence of HPV DNA and p53 expression.
  • We did not find any significant differences in tobacco and alcohol consumption between patients with BSCC and patients with SCC.
  • No HPV DNA was detected in BSCC, and p53 overexpression was found in five (55%) of the cases.
  • Our results do not support an etiological link between HPV DNA and BSCC.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. DNA, Viral / biosynthesis. Papillomaviridae / genetics. Pharyngeal Neoplasms / epidemiology


78. Liao CT, Wang HM, Ng SH, Yen TC, Lee LY, Hsueh C, Wei FC, Chen IH, Kang CJ, Huang SF, Chang JT: Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan. Oral Oncol; 2006 Sep;42(8):800-9
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  • [Title] Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan.
  • The aim was to analyze the survival and prognostic factors in 232 patients with squamous cell carcinoma of the buccal mucosa (BSCC) treated with radical surgery with or without neck dissection (ND).
  • Both pathologic nodal status and cell differentiation were the significant prognostic factors of disease-free survival.
  • Our result showed a relatively better tumor control and survivals in BSCC with radical surgery with or without ND.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Neck Dissection
  • [MeSH-minor] Adult. Aged. Cell Differentiation. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Mouth Mucosa. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant. Treatment Outcome


79. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C: Basal cell adenoma of the parotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E206-9
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  • [Title] Basal cell adenoma of the parotid gland. Case report and review of the literature.
  • Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma.
  • Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is mandatory.
  • We describe a case of basal cell adenoma of the parotid gland.
  • We also review the literature and discuss the diagnosis and management of this rare entity.

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  • (PMID = 16505803.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 21
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80. Rodríguez Tojo MJ, García Cano FJ, Infante Sánchez JC, Velázquez Fernández E, Aguirre Urízar JM: Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx. Clin Transl Oncol; 2005 Apr;7(3):110-4
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  • [Title] Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx.
  • INTRODUCTION: Basaloid is a rare and poorly-differentiated variant of squamous cell carcinoma of the larynx, with an invasive solid growth of cells in a lobular configuration.
  • OBJECTIVE: To evaluate the relationship between the immunoexpression of p53, Ki-67 and E-cadherin in relation to prognosis in basaloid squamous cell carcinoma of the larynx (BSCCL).
  • CONCLUSIONS: BSCCL is an aggressive variant of the squamous cell carcinoma and has a high expression of p53 and Ki-67 with a low expression of Ecadherin.
  • [MeSH-major] Cadherins / biosynthesis. Carcinoma, Squamous Cell / immunology. Ki-67 Antigen / biosynthesis. Laryngeal Neoplasms / immunology. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 15899218.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Cadherins; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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81. Rau AR, Kini H, Naik R, Sahu KK: Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma. Indian J Pathol Microbiol; 2005 Jan;48(1):31-3
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  • [Title] Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma.
  • Basaloid squamous cell carcinoma (BSCC) is a high grade variant of Squamous Cell Carcinoma with a predilection for the aero-digestive tract.
  • The typical microscopic features of carcinoma with a basaloid pattern in intimate association with a squamous component helps in diagnosis of this tumour.
  • This study discusses the differential diagnosis of BSCC, as recognition of this tumour may have therapeutic implications.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology

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  • (PMID = 16758784.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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82. Shibata Y, Baba E, Ariyama H, Miki R, Ogami N, Arita S, Qin B, Kusaba H, Mitsugi K, Noshiro H, Yao T, Nakano S: Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin. World J Gastroenterol; 2007 Jul 14;13(26):3634-7
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  • [Title] Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin.
  • Basaloid squamous cell carcinoma (BSC) of the esophagus is a rare malignant disease.
  • A 57-year-old woman was diagnosed as having squamous cell carcinoma of the esophagus upon endoscopic examination.
  • The pathological diagnosis of the surgical specimen was BSC.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Esophageal Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 17659717.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC4146806
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83. Hammar SP: Approach to the diagnosis of neuroendocrine lung neoplasms: variabilities and pitfalls. Semin Thorac Cardiovasc Surg; 2006;18(3):183-90
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  • [Title] Approach to the diagnosis of neuroendocrine lung neoplasms: variabilities and pitfalls.
  • With the publication of the spectrum of neuroendocrine proliferations and neoplasms and the features and criteria for diagnosing neuroendocrine lung neoplasms, there is more agreement in making a specific pathologic diagnosis of a neuroendocrine lung neoplasm.
  • However, problems exist, especially in diagnosing well-differentiated neuroendocrine carcinomas (atypical carcinoids), large-cell neuroendocrine carcinomas, and even some small-cell lung cancers.
  • Nonneuroendocrine small-cell carcinomas exist and include small-cell squamous cell carcinoma, small cell adenocarcinoma, and basaloid carcinoma.
  • Nonneuroendocrine lung cancers, especially large-cell undifferentiated carcinoma and poorly differentiated adenocarcinoma, not infrequently express neuroendocrine markers immunohistochemically.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Humans. Immunohistochemistry

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  • (PMID = 17185177.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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84. Hatta N, Hirano T, Kimura T, Hashimoto K, Mehregan DR, Ansai S, Takehara K, Takata M: Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels. J Cutan Pathol; 2005 Feb;32(2):131-6
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  • [Title] Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels.
  • BACKGROUND: Distinguishing basal cell carcinoma (BCC) from other benign and malignant skin tumors is sometimes a difficult task for the pathologists.
  • Because the activation of hedgehog signals and the up-regulation of its critical transcriptional factor Gli1 are well documented in BCC, a molecular technique measuring Gli1 transcripts may aide the diagnosis.
  • The tumors included BCC (21), squamous cell carcinoma (13), seborrheic keratoses (8), trichoepithelioma (5), eccrine poroma/porocarcinoma (4), and sebaceous epithelioma/carcinoma (2).
  • The diagnosis was discordant among three pathologists in the remaining 15 tumors.
  • Histological diagnoses included BCC, BCC with sebaceous differentiation, sebaceoma/sebaceous epithelioma, trichoblastoma, trichoepithelioma, basaloid follicular harmartoma, basosquamous carcinoma, etc.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Oncogene Proteins / metabolism. Skin Neoplasms / diagnosis. Transcription Factors / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Trans-Activators. Transcription, Genetic

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  • (PMID = 15606671.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gli protein; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / Trans-Activators; 0 / Transcription Factors
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85. Chute DJ, Stelow EB: Cytology of head and neck squamous cell carcinoma variants. Diagn Cytopathol; 2010 Jan;38(1):65-80
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  • [Title] Cytology of head and neck squamous cell carcinoma variants.
  • The most common diagnosis rendered with head and neck fine needle aspiration (FNA) biopsy is metastatic squamous cell carcinoma (SCC).
  • While most cases of metastatic SCC pose little diagnostic difficulty, the diagnosis of metastatic histologic variants of SCC, often coupled with less common etiologies, can be more problematic.
  • This manuscript reviews the clinicopathologic features of the histologic variants of upper aerodigestive tract SCC (verrucous, papillary, spindle cell, undifferentiated, acantholytic, and basaloid) and uncommon etiologies of head and neck SCC (human papillomavirus, Epstein-Barr Virus, and NUT midline carcinomas).
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology


86. Ereño C, Gaafar A, Garmendia M, Etxezarraga C, Bilbao FJ, López JI: Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature. Head Neck Pathol; 2008 Jun;2(2):83-91
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  • [Title] Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature.
  • Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of cancer that mainly arises in the upper aerodigestive tract.
  • The basaloid component predominated in 29 cases (72.5%).
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Mouth Neoplasms / diagnosis. Otorhinolaryngologic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / mortality. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / mortality. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Neoplasms, Multiple Primary. Oropharyngeal Neoplasms / diagnosis. Oropharyngeal Neoplasms / mortality. Survival Rate

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  • (PMID = 20614328.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807543
  • [Keywords] NOTNLM ; Basaloid-squamous cell carcinoma / Differential diagnosis / Head and neck / Hypopharynx / Larynx / Metastasis / Oral cavity / Oropharynx / Prognosis / Recurrence
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87. Kocjan G, Priollet BC, Desai M, Koutselini H, Mahovlic V, Oliveira MH, Pohar-Marinsek Z, Sauer T, Schenk U, Shabalova I, Herbert A: BSCC, Bethesda or other? Terminology in cervical cytology European panel discussion. Cytopathology; 2005 Jun;16(3):113-9
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  • [Title] BSCC, Bethesda or other? Terminology in cervical cytology European panel discussion.
  • [MeSH-minor] Europe. Female. Humans. Uterine Cervical Dysplasia / classification. Uterine Cervical Dysplasia / diagnosis. Uterine Cervical Neoplasms / classification. Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 15924605.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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88. Blot WJ, Signorello LB, Cohen SS, Ibrahim MA: Single leg separation prevalence among explanted Björk-Shiley prosthetic heart valves. J Heart Valve Dis; 2007 Nov;16(6):657-61
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  • BACKGROUND AND AIM OF THE STUDY: Björk-Shiley convexo-concave (BSCC) prosthetic heart valves are believed to have been implanted in over 86,000 patients worldwide.
  • By applying the size, position and angle-specific SLS prevalences to the worldwide valve distribution, it is estimated that SLS may be present in 6.8% (95% confidence limits 4.1-9.4%) of all BSCC valves.
  • CONCLUSION: These findings suggest that SLS may affect between 820 and 1,880 of the almost 20,000 BSCC valves among surviving patients worldwide.

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  • (PMID = 18095516.001).
  • [ISSN] 0966-8519
  • [Journal-full-title] The Journal of heart valve disease
  • [ISO-abbreviation] J. Heart Valve Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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89. Blot WJ, Ibrahim MA, Ivey TD, Acheson DE, Brookmeyer R, Weyman A, Defauw J, Smith JK, Harrison D: Twenty-five-year experience with the Björk-Shiley convexoconcave heart valve: a continuing clinical concern. Circulation; 2005 May 31;111(21):2850-7
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  • BACKGROUND: The first Björk-Shiley convexoconcave (BSCC) prosthetic heart valves were implanted in 1978.
  • The 25th anniversary provided a stimulus to summarize the research data relevant to BSCC valve fracture, patient management, and current clinical options.
  • METHODS AND RESULTS: Published and unpublished data on the risks of BSCC valve fracture and replacement were compiled, and strategies for identifying candidates for prophylactic valve reoperation were summarized.
  • By December 2003, outlet strut fractures (OSFs), often with fatal outcomes, had been reported in 633 BSCC valves (0.7% of 86,000 valves implanted).
  • By comparing individualized estimated risks of OSF versus valve replacement, guidelines have been developed to identify the small percentage of BSCC patients (mostly younger men) who would be expected to have a gain in life expectancy should reoperative surgery be performed.
  • CONCLUSIONS: Twenty-five years after the initial BSCC valve implants, fractures continue to occur.
  • Continued monitoring of BSCC patients is needed to track and quantify risks and enable periodic updating of guidelines for patients and their physicians.

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  • [CommentIn] Circulation. 2005 May 31;111(21):2717-9 [15927988.001]
  • (PMID = 15927993.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Hung JJ, Li AF, Liu JS, Lin YS, Hsu WH: Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma. Ann Thorac Surg; 2008 Mar;85(3):1102-4
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  • [Title] Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma.
  • It often presents as a large intraluminal polypoid tumor with early onset of symptoms resulting in prompt diagnosis.
  • We present here the first case of a carcinosarcoma of the esophagus that had a basaloid squamous cell carcinoma component in addition to the osteosarcoma and without a transitional zone.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinosarcoma / pathology. Esophageal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Osteosarcoma / pathology


91. Knopf A, Schneider J, Schipper J, Hoffmann TK, Bas M: [Sinonasal basaloid squamous cell carcinoma in biopsies of inverted papilloma]. HNO; 2008 Aug;56(8):808-12
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  • [Title] [Sinonasal basaloid squamous cell carcinoma in biopsies of inverted papilloma].
  • [Transliterated title] Das sinonasale basaloid-squamöse Karzinom in Biopsien eines invertierten Papilloms.
  • Basaloid squamous cell carcinoma (BSCC) is a rare tumor representing an aggressive variant of squamous cell carcinoma (SCC) and arising from a common precursor cell.
  • BSCC rarely originates from the sinonasal tract.
  • We report on an 83-year-old woman with BSCC after multiple resections of an inverted papilloma (IP) of the left sinonasal tract.
  • A possible association between sinonasal BSCC and IP, as implicated by the current case, must be further investigated.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Squamous Cell / pathology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 17876561.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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92. Chaux A, Reuter V, Lezcano C, Velazquez EF, Torres J, Cubilla AL: Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases. Am J Surg Pathol; 2009 Sep;33(9):1299-306
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases.
  • Penile squamous cell carcinoma (SCC) is considered a loco-regional disease with a fairly predictable pattern of progression.
  • Comparison of recurrent tumors at the time of the primary diagnosis and of recurrence showed that histologic subtype and grade were identical in 76% of the cases and converted to a higher grade tumor in 24% of the cases, especially, in patients treated with local excisions and circumcisions.
  • Comparison of recurrent and nonrecurrent tumors showed that high grade tumors (basaloid and sarcomatoid) tended to be significantly associated with recurrent tumors, whereas low grade variants (papillary, warty and verrucous) were more frequent in the nonrecurrent group; recurrent tumors invaded into deeper anatomic levels than nonrecurrent tumors.
  • Mortality was higher in the recurrent group (56% vs. 29%, P=0.0188); 80% of patients with high-grade tumors (basaloid, sarcomatoid, and high grade usual or hybrid verrucous SCCs) died from penile cancer.
  • Mortality in patients with usual SCC was higher in the recurrent group, but similar in basaloid and sarcomatoid SCCs.
  • In summary, histologic subtypes and grades of SCCs were similar in the majority of original and recurrent carcinomas.
  • Inguinal metastasis and mortality were higher in recurrent than in nonrecurrent carcinomas.
  • Basaloid, sarcomatoid, and mixed usual-verrucous variants and invasion of corpora cavernosa or preputial skin were significant adverse prognostic factors of recurrent carcinomas.
  • Local excision and partial penectomy were not adequate procedures for sarcomatoid and basaloid penile carcinomas.
  • Carcinomas of foreskin had a better prognosis.
  • Conversion from low to high-grade carcinoma was related to significant mortality.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Neoplasm Recurrence, Local / pathology. Penile Neoplasms / pathology

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  • (PMID = 19471153.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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93. Sampaio-Góes FC, Oliveira DT, Dorta RG, Nonogaki S, Landman G, Nishimoto IN, Kowalski LP: Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: relationships with prognosis. Head Neck; 2005 Nov;27(11):982-9
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  • [Title] Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: relationships with prognosis.
  • BACKGROUND: The aim of this study was to compare the clinical features and proliferating cell nuclear antigen (PCNA), p53, Bcl-X, and Bax expression in primary oral basaloid squamous cell carcinoma (BSCC) and poorly differentiated squamous cell carcinoma (PDSCC) matched by stage and site and to assess the possible prognostic significance of these variables.
  • METHODS: Seventeen cases of oral BSCC were compared with 27 PDSCCs matched by stage and tumor site.
  • In addition, PCNA, p53, Bax, and Bcl-X expression in both carcinomas were evaluated in relation to their clinicopathologic features and prognostic values using the Kaplan-Meier method and Cox regression models.
  • RESULTS: No statistically significant differences were found between the groups (BSCC and PDSCC) in regard to clinical features and immunohistochemical reactivity for antibodies PCNA, p53, and Bcl-X.
  • In comparison with PDSCC, the BSCC group exhibited a higher Bax score (p = .031).
  • The 5-year and 10-year overall survival, cancer-specific survival, and disease-free survival rates demonstrated no significant differences between the BSCC and PDSCC groups, and the PCNA, p53, Bax, and Bcl-X also showed no prognostic value.
  • CONCLUSIONS: These results suggest that the clinical and biologic course of BSCC is similar to PDSCC in the oral cavity when clinical stage and site are matched.
  • [MeSH-major] Mouth Neoplasms / pathology. Neoplasms, Squamous Cell / pathology. Proliferating Cell Nuclear Antigen / analysis. Tumor Suppressor Protein p53 / analysis. bcl-2-Associated X Protein / analysis. bcl-X Protein / analysis


94. Longacre TA, Kong CS, Welton ML: Diagnostic problems in anal pathology. Adv Anat Pathol; 2008 Sep;15(5):263-78
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  • Anal squamous cell carcinoma and its precursor lesions are increasing in incidence in the United States and Europe.
  • This trend predates human immunodeficiency virus/acquired immune deficiency syndrome and has been associated with persistent high-risk human papilloma virus (HPV) genotype infection, previous lower genital tract dysplasia/carcinoma, high frequency anoreceptive intercourse, heavy cigarette smoking, immunosuppression in solid organ transplant and immune disorders, and human immunodeficiency virus seropositivity.
  • Screening protocols for at-risk patients are under active investigation and pathologists are often asked to assess anal canal and perianal biopsies for the presence of dysplasia and/or invasive carcinoma.
  • Because underdiagnosis and overdiagnosis of anal cancer and precancer may lead to inappropriate treatment, it is important for the pathologist to be aware of current screening strategies, specific risk lesions, and the role of pathology in initial diagnosis and evaluation of anal biopsy and/or resection specimens.
  • Standardized histologic criteria and uniform terminology should be used for reporting all anal canal and perianal squamous intraepithelial lesions.
  • HPV has been linked to all the major histologic subtypes of anal carcinoma (eg, basaloid, cloacogenic, transitional, etc.) and this association is strongest for anal canal lesions.
  • With the possible exception of the microcystic pattern, histologic subtype does not seem to predict prognosis; and anal squamous cell carcinomas should be classified as either keratinizing or nonkeratinizing.
  • Poorly differentiated squamous cell carcinomas have a worse prognosis and should be distinguished from poorly differentiated adenocarcinoma, melanoma, and neuroendocrine tumors.
  • Very well differentiated squamous cell carcinoma with pushing margins (so-called giant condyloma of Buschke and Lowenstein) should be classified as verrucous carcinoma; this tumor shows aggressive local infiltration but does not metastasize.
  • As all anal condylomata may harbor foci of high-grade dysplasia or invasive carcinoma, careful sectioning and complete histologic examination is required.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology
  • [MeSH-minor] Carcinoma, Verrucous / pathology. Condylomata Acuminata / pathology. Diagnosis, Differential. Humans. Papillomaviridae / genetics. Risk Factors. Terminology as Topic

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  • (PMID = 18724100.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 73
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95. Farrell T, Chang YL: Basal cell adenocarcinoma of minor salivary glands. Arch Pathol Lab Med; 2007 Oct;131(10):1602-4
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  • [Title] Basal cell adenocarcinoma of minor salivary glands.
  • Basal cell adenocarcinoma of minor salivary glands is a relatively rare slow-growing tumor with an infiltrating growth pattern.
  • The infiltrating growth pattern and likelihood of vascular and perineural involvement distinguishes basal cell adenocarcinoma from basal cell adenoma.
  • Other diagnostic considerations include adenoid cystic carcinoma and basaloid squamous carcinoma.
  • Basal cell adenocarcinomas show strong immunoreactivity to cytokeratin 7 and variable myoepithelial staining with S100.
  • It is necessary to differentiate basal cell adenocarcinoma from other basaloid cell tumors of the minor salivary glands because of the prognosis and potential differences in treatment, particularly adenoid cystic adenocarcinoma and basaloid squamous carcinoma.
  • Surgical excision with a wide margin to ensure complete removal has been suggested as the primary treatment for basal cell adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Salivary Gland Neoplasms / diagnosis. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Squamous Cell / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Humans

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  • (PMID = 17922602.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Oztürk O, Sari M, Inanli S, Kara EK: Basaloid squamous cell carcinoma of the larynx: a case report. Kulak Burun Bogaz Ihtis Derg; 2005;15(5-6):125-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the larynx: a case report.
  • Basaloid squamous cell carcinoma (SCC) is a very rare, high grade, and aggressive variant of SCC, with a predilection for the upper aerodigestive system.
  • We present a 50-year-old man with basaloid SCC of the supraglottic larynx, which was initially misdiagnosed as SCC.
  • Basaloid SCC should be considered in the differential diagnosis of upper aerodigestive system malignancies because it has a distinct prognostic significance compared to conventional SCC.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16444094.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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97. Oikawa K, Tabuchi K, Nomura M, Okubo H, Wada T, Iijima T, Hara A: Basaloid squamous cell carcinoma of the maxillary sinus: a report of two cases. Auris Nasus Larynx; 2007 Mar;34(1):119-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the maxillary sinus: a report of two cases.
  • Basaloid squamous cell carcinoma (BSCC) is a highly aggressive neoplasm and a histologically distinctive variant of squamous cell carcinoma.
  • Since the first description by Wain et al. in 1986, only 18 cases with BSCC in the nasal cavity or in the paranasal cavity have been reported in the English literature.
  • We report herein two cases of BSCC of the maxillary sinus.
  • He died of lung metastasis 6 months after the initial diagnosis.
  • We reviewed the clinical features of BSCC from the literature.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Maxillary Sinus / pathology. Maxillary Sinus / radiography. Paranasal Sinus Neoplasms / diagnosis

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  • (PMID = 17141998.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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98. Herbert A, Gray W, Cross P: Terminology of the BSCC, European Community and the Bethesda system: the boundary between low-grade and high-grade cytology. Cytopathology; 2009 Feb;20(1):3-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Terminology of the BSCC, European Community and the Bethesda system: the boundary between low-grade and high-grade cytology.
  • [MeSH-major] Cell Biology / standards. Cervical Intraepithelial Neoplasia. Terminology as Topic. Vaginal Smears

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  • [CommentIn] Cytopathology. 2009 Jun;20(3):206-7 [19489987.001]
  • [CommentOn] Cytopathology. 2009 Feb;20(1):17-26 [18510551.001]
  • [CommentOn] Cytopathology. 2009 Feb;20(1):5-16 [19133067.001]
  • (PMID = 19133066.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] England
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99. Yu GY, Gao Y, Peng X, Chen Y, Zhao FY, Wu MJ: A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region. Int J Oral Maxillofac Surg; 2008 Nov;37(11):1003-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region.
  • Basaloid squamous cell carcinoma (BSCC) is a rare distinct variant of squamous cell carcinoma (SCC).
  • To investigate its clinical behavior and prognosis, 15 patients with BSCC in the oral and maxillofacial region were clinically analyzed and compared with 15 patients with conventional SCC matched for site, stage, gender and age.
  • CK 7, CK 8, proliferating cell nuclear antigen (PCNA) and p53 were reviewed from 12 patients with BSCC.
  • The rate of cervical lymph node metastasis of BSCC was as high as 67% and that of distant metastasis 13%.
  • In most BSCC patients (10/12) the PCNA index was over 50%.
  • Twelve BSCC patients were diagnosed with grade II or III conventional SCC when the original records of the primary diagnosis for the 15 patients with BSCC were reviewed.
  • The biological behavior and prognosis of BSCC are similar to those of poorly differentiated SCC.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Mouth Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Case-Control Studies. Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Proliferating Cell Nuclear Antigen / metabolism. Survival Rate


100. Ozgursoy OB, Yorulmaz I, Tulunay O: Rapid and unusual spread of basaloid squamous cell carcinoma of the maxillary sinus. B-ENT; 2008;4(4):233-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid and unusual spread of basaloid squamous cell carcinoma of the maxillary sinus.
  • Basaloid squamous cell carcinoma is a variant of epidermoid carcinoma with a morphology consisting of both basaloid and squamous cell components.
  • In this report, we present the aggressive course of a basaloid squamous cell carcinoma of the maxillary sinus in a 28-year-old patient who died only four months after the initial diagnosis.
  • [MeSH-major] Carcinoma, Basosquamous / secondary. Maxillary Sinus Neoplasms / pathology

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  • (PMID = 19227029.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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