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1. Chernock RD, Lewis JS Jr, Zhang Q, El-Mofty SK: Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. Hum Pathol; 2010 Jul;41(7):1016-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma.
  • Basaloid squamous cell carcinoma of the upper aerodigestive tract is a rare, morphologically distinct variant of squamous cell carcinoma that is thought to be clinically aggressive.
  • The histologic features are distinct from, but often confused with, those of human papillomavirus-related oropharyngeal nonkeratinizing squamous cell carcinoma.
  • The role of human papillomavirus as an etiologic agent in true basaloid squamous cell carcinoma is controversial.
  • The purpose of this study was to determine human papillomavirus prevalence and its clinicopathologic significance in upper aerodigestive tract tumors with true basaloid squamous cell carcinoma histology.
  • Overall survival was better for human papillomavirus-positive basaloid squamous cell carcinomas (P < .05), with 86% of patients alive at 3 years compared with 35.3% of patients with human papillomavirus-negative tumors.
  • These findings suggest that a subset of basaloid squamous cell carcinomas is virally driven.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Hypopharyngeal Neoplasms / virology. Laryngeal Neoplasms / virology. Oropharyngeal Neoplasms / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / complications

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • [CommentIn] Hum Pathol. 2010 Oct;41(10):1505-6; author reply 1506 [20868902.001]
  • (PMID = 20236687.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA091842; United States / NCI NIH HHS / CA / P30 CA091842
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS534623; NLM/ PMC3873737
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2. Emanuel P, Wang B, Wu M, Burstein DE: p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol; 2005 May;18(5):645-50
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  • [Title] p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.
  • Morphologic distinction of high-grade adenoid cystic carcinoma from basaloid squamous cell carcinoma can be difficult.
  • We have investigated the possibility that immunohistochemical staining for the presence of p63, a novel epithelial stem-cell regulatory protein, could be a useful means of distinguishing these two neoplasms.
  • Archival, routinely processed slides were subjected to citrate-based antigen retrieval, exposure to anti-p63 monoclonal 4A4, and developed with a streptavidin-biotin kit and diaminobenzidine as chromogen. p63 was detected in 100% of the adenoid cystic carcinomas (n=14) and 100% of basaloid squamous cell carcinomas (n=16).
  • Basaloid squamous cell carcinomas consistently displayed diffuse p63 positivity, with staining of nearly 100% of tumor cells.
  • In contrast, adenoid cystic carcinoma displayed a consistently compartmentalized pattern within tumor nests.
  • (1) selective staining of a single peripheral layer of p63-positive cells surrounding centrally located tumor cells that were p63-negative and (2) tumor nests consisting of multiple contiguous glandular/cribriform-like units of p63-positive cells surrounding or interspersed with p63-negative cells. p63 immunostaining constitutes a specific and accurate means of distinguishing adenoid cystic carcinoma from basaloid squamous cell carcinoma. p63 positivity in adenoid cystic carcinoma appears to be homologous to that seen in the basal and/or myoepithelial compartments of salivary gland and other epithelia, and may signify a stem-cell-like role for these peripheral cells.
  • Diffuse p63 positivity in basaloid squamous cell carcinoma suggests dysregulation of p63-positive stem cells in poorly differentiated squamous carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Phosphoproteins / analysis. Trans-Activators / analysis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 15529180.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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3. Vasudev P, Boutross-Tadross O, Radhi J: Basaloid squamous cell carcinoma: two case reports. Cases J; 2009;2:9351
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  • [Title] Basaloid squamous cell carcinoma: two case reports.
  • Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of squamous cell carcinoma (SCC) that occurs preferentially in the upper aerodigestive tract.
  • We present two cases of BSCC, one arising in the conjunctiva and the other arising in a paranasal sinus.
  • To the best of our knowledge, this is the first report of BSCC of the conjunctiva.
  • BSCC of the head and neck should be distinguished from adenoid cystic carcinoma, small cell neuroendocrine carcinoma, basal cell adenocarcinoma, adenosquamous carcinoma, squamous cell carcinoma, spindle cell squamous carcinoma, mucoepidermoid carcinoma, and adenoid cystic carcinoma.

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  • (PMID = 20062602.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2804002
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4. Salerno G, Di Vizio D, Staibano S, Mottola G, Quaremba G, Mascolo M, Galli V, De Rosa G, Insabato L: Prognostic value of p27Kip1 expression in Basaloid Squamous Cell Carcinoma of the larynx. BMC Cancer; 2006;6:146
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  • [Title] Prognostic value of p27Kip1 expression in Basaloid Squamous Cell Carcinoma of the larynx.
  • BACKGROUND: Very few reports have investigated the role of cell cycle regulators as biomarkers in Basaloid Squamous Cell Carcinoma (BSCC) of the larynx, a definite morphologic, uncommon, very aggressive variant of squamous cell carcinoma.
  • Lower expression of Ki67/Mib-1, a proliferation marker highly expressed in the majority of tumours, and p53, a tumour suppressor protein that can induce an arrest of the G1-S transition, was related to a better prognosis in laryngeal BSCC.
  • Up to date the role of this protein was never studied in BSCC.
  • Aim of our study was to investigate the potential prognostic value of p27kip1 levels and their correlation with Ki67/Mib-1 and p53 expression in BSCC of the larynx.
  • METHODS: The retrospective study group consisted of 15 male and 1 female patients, affected by laryngeal BSCC, ranging in age from 44 to 69 years (mean 58).
  • In our series of laryngeal BSCC the resulting data seem to confirm the clinical prognostic relevance of p27kip1 low expression, which directly correlated with biological aggressiveness and consequent shortened survival.
  • [MeSH-major] Biomarkers / analysis. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / metabolism

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  • (PMID = 16740156.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CDKN1B protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ PMC1559634
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5. Morales-Puebla JM, Toro-Rojas M, Segura-Saint-Gerons R, Fanego-Fernández J, López-Villarejo P: Basaloid squamous cell carcinoma: report of five cases. Med Oral Patol Oral Cir Bucal; 2010 May;15(3):e451-5
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  • [Title] Basaloid squamous cell carcinoma: report of five cases.
  • OBJECTIVES: To document the clinical and histopathological characteristics of basaloid squamous cell carcinoma (BSCC).
  • CASES: retrospective review of five cases with the diagnosis of BSCC of the larynx.
  • CONCLUSIONS: BSCC has well defined histological features.
  • Central comedonecrosis within the cells nests, cell with nuclear palisading and high-grade dysplasia in overlaying mucosa are the main characteristics.
  • [MeSH-major] Carcinoma, Squamous Cell. Laryngeal Neoplasms

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  • (PMID = 20038913.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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6. Joshi NP, Haresh KP, Das P, Kumar R, Prabhakar R, Sharma DN, Heera P, Julka PK, Rath GK: Unresectable basaloid squamous cell carcinoma of the trachea treated with concurrent chemoradiotherapy: a case report with review of literature. J Cancer Res Ther; 2010 Jul-Sep;6(3):321-3
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  • [Title] Unresectable basaloid squamous cell carcinoma of the trachea treated with concurrent chemoradiotherapy: a case report with review of literature.
  • Basaloid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma of the trachea.
  • We describe the case of an unresectable basaloid squamous cell carcinoma of the trachea treated with concurrent chemoradiotherapy up to a dose of 60 Gy in 33 fractions with weekly paclitaxel and carboplatin.
  • The pathological recognition of basaloid squamous cell carcinoma and its distinction from adenoid cystic carcinoma of the trachea is important for its management.
  • Combining systemic chemotherapy with locoregional radiation is a logical approach to treatment, especially for the basaloid squamous cell carcinoma of the trachea, given its tendency to metastasize early after definitive therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Tracheal Neoplasms / therapy

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  • (PMID = 21119264.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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7. Thariat J, Ahamad A, El-Naggar AK, Williams MD, Holsinger FC, Glisson BS, Allen PK, Morrison WH, Weber RS, Ang KK, Garden AS: Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck: a case-control study. Cancer; 2008 Jun 15;112(12):2698-709
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  • [Title] Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck: a case-control study.
  • BACKGROUND: Basaloid squamous cell carcinoma (BSCC) is an uncommon, high-grade variant of squamous cell carcinoma (SCC) of the head and neck.
  • The authors investigated the outcomes of patients with BSCC who received radiotherapy and compared them with the outcomes of patients with SCC.
  • METHODS: From 1994 to 2004, 1007 patients received radiotherapy for head and neck carcinoma with lymph node involvement.
  • The histologic types consisted of 51 BSCC, 431 poorly differentiated SCC (PSCC), and 525 well or moderately differentiated SCC (WMSCC).
  • A case-control analysis was performed with BSCC matched against both PSCC and WMSCC to compare disease-control and survival rates.
  • RESULTS: Patients with BSCC received treatment modalities similar to those received by patients with SCC: They received induction chemotherapy (12%) or concurrent chemotherapy (33%), and a median radiation dose of 70 Gray.
  • Posttreatment viable tumor was present in 44%, 13%, and 28% of neck dissection specimens from patients with BSCC, PSCC, and WMSCC, respectively.
  • The 5-year disease-free survival rates (63%, 77%, and 76%, respectively) and overall survival rates (85%, 70%, and 71%, respectively) demonstrated no statistically significant differences for BSCC, PSCC, or WMSCC, respectively.
  • CONCLUSIONS: In this study, a poorer prognosis could not be demonstrated for irradiated patients with BSCC compared with either PSCC or WMSCC.
  • The BSCC cohort did have a relatively high rate of viable tumor in their posttreatment neck dissections, and they had a relatively high rate of distant disease.
  • [MeSH-major] Carcinoma, Basosquamous / radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Head and Neck Neoplasms / radiotherapy

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  • [Copyright] Copyright (c) 2008 American Cancer Society.
  • (PMID = 18429002.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA06294
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Ban JH, Lee JK, Jin SM, Lee KC: Basaloid squamous cell carcinoma of the external auditory canal: case report. Eur Arch Otorhinolaryngol; 2007 Jun;264(6):697-9
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  • [Title] Basaloid squamous cell carcinoma of the external auditory canal: case report.
  • Basaloid squamous cell carcinoma (BSCC) is a rare malignancy, with features of both basal cell carcinoma and squamous cell carcinoma.
  • The tumor has a predilection for the upper aerodigestive tract, and has been suggested to behave more aggressively than squamous cell carcinoma (SCC).
  • To the author's knowledge, BSCC confined to the external auditory canal (EAC) has not been previously described.
  • BSCC of EAC manifests similar characteristics as the conventional EAC cancer, presenting a mass with chronic otorrhea and itching sense.
  • This report describes the first case of BSCC in this location, and includes reviews of the pathologic and clinical aspects of this disease.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Ear Canal / pathology. Ear Neoplasms / pathology

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  • (PMID = 17235532.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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9. Bekavac-Beslin M, Mijić A, Matejcić A, Ferencić Z: Basaloid squamous cell carcinoma of the esophagus: a case report. Tumori; 2005 Jan-Feb;91(1):87-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the esophagus: a case report.
  • Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma.
  • We present the case of a 48-year-old male patient with esophageal BSCC.
  • In our patient the surgical specimen revealed BSCC with an aggressive pattern (invasion of the whole esophageal wall thickness, lymph node metastases and intraneural spread).
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy

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  • (PMID = 15850013.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. Oztürk O, Sari M, Inanli S, Kara EK: Basaloid squamous cell carcinoma of the larynx: a case report. Kulak Burun Bogaz Ihtis Derg; 2005;15(5-6):125-9
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  • [Title] Basaloid squamous cell carcinoma of the larynx: a case report.
  • Basaloid squamous cell carcinoma (SCC) is a very rare, high grade, and aggressive variant of SCC, with a predilection for the upper aerodigestive system.
  • We present a 50-year-old man with basaloid SCC of the supraglottic larynx, which was initially misdiagnosed as SCC.
  • Basaloid SCC should be considered in the differential diagnosis of upper aerodigestive system malignancies because it has a distinct prognostic significance compared to conventional SCC.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16444094.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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11. Hirai E, Yamamoto K, Yamamoto N, Yamashita Y, Kounoe T, Kondo Y, Yonemasu H, Takahashi T, Kurokawa H: Basaloid squamous cell carcinoma of the mandible: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Nov;108(5):e54-8
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  • [Title] Basaloid squamous cell carcinoma of the mandible: report of two cases.
  • Basaloid squamous cell carcinoma is a rare aggressive malignancy that is a distinct variant of squamous cell carcinoma.
  • This report presents 2 cases of basaloid squamous cell carcinoma in the gingiva.
  • Both tumors were diagnosed histopathologically as basaloid squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Gingival Neoplasms / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 19836714.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA: Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis. J Clin Pathol; 2010 Oct;63(10):857-66
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  • [Title] Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
  • Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma (SCC) of the head and neck.
  • Wain's criteria (peripheral palisading, association with SCC, high nuclear-cytoplasmic ratio, high mitotic rate, solid growth), anti-34BE12 and CK 5/6 staining, and absence of neuroendocrine markers are mandatory for the diagnosis of BSCC.
  • On the other hand, BSCC is frequently considered a high-grade carcinoma of poorer prognosis than its SCC counterparts, mostly due to a higher rate of distant metastases.
  • However, BSCC has similar or better locoregional control rates and a relatively better radiosensitivity than SCC.
  • BSCC seems to have a dual behaviour depending, at least partly, on its recently described association with HPV.
  • The basaloid subtype of SCC, owing to its particular behaviour, should be systematically investigated along with HPV and smoking status, as those factors may be determinant in the response to treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Head and Neck Neoplasms / virology. Papillomavirus Infections / complications
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Combined Modality Therapy. Diagnosis, Differential. Humans. Prognosis


13. Oikawa K, Tabuchi K, Nomura M, Okubo H, Wada T, Iijima T, Hara A: Basaloid squamous cell carcinoma of the maxillary sinus: a report of two cases. Auris Nasus Larynx; 2007 Mar;34(1):119-23
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  • [Title] Basaloid squamous cell carcinoma of the maxillary sinus: a report of two cases.
  • Basaloid squamous cell carcinoma (BSCC) is a highly aggressive neoplasm and a histologically distinctive variant of squamous cell carcinoma.
  • Since the first description by Wain et al. in 1986, only 18 cases with BSCC in the nasal cavity or in the paranasal cavity have been reported in the English literature.
  • We report herein two cases of BSCC of the maxillary sinus.
  • He died of lung metastasis 6 months after the initial diagnosis.
  • We reviewed the clinical features of BSCC from the literature.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Maxillary Sinus / pathology. Maxillary Sinus / radiography. Paranasal Sinus Neoplasms / diagnosis

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  • (PMID = 17141998.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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14. Sampaio-Góes FC, Oliveira DT, Dorta RG, Nonogaki S, Landman G, Nishimoto IN, Kowalski LP: Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: relationships with prognosis. Head Neck; 2005 Nov;27(11):982-9
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  • [Title] Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: relationships with prognosis.
  • BACKGROUND: The aim of this study was to compare the clinical features and proliferating cell nuclear antigen (PCNA), p53, Bcl-X, and Bax expression in primary oral basaloid squamous cell carcinoma (BSCC) and poorly differentiated squamous cell carcinoma (PDSCC) matched by stage and site and to assess the possible prognostic significance of these variables.
  • METHODS: Seventeen cases of oral BSCC were compared with 27 PDSCCs matched by stage and tumor site.
  • In addition, PCNA, p53, Bax, and Bcl-X expression in both carcinomas were evaluated in relation to their clinicopathologic features and prognostic values using the Kaplan-Meier method and Cox regression models.
  • RESULTS: No statistically significant differences were found between the groups (BSCC and PDSCC) in regard to clinical features and immunohistochemical reactivity for antibodies PCNA, p53, and Bcl-X.
  • In comparison with PDSCC, the BSCC group exhibited a higher Bax score (p = .031).
  • The 5-year and 10-year overall survival, cancer-specific survival, and disease-free survival rates demonstrated no significant differences between the BSCC and PDSCC groups, and the PCNA, p53, Bax, and Bcl-X also showed no prognostic value.
  • CONCLUSIONS: These results suggest that the clinical and biologic course of BSCC is similar to PDSCC in the oral cavity when clinical stage and site are matched.
  • [MeSH-major] Mouth Neoplasms / pathology. Neoplasms, Squamous Cell / pathology. Proliferating Cell Nuclear Antigen / analysis. Tumor Suppressor Protein p53 / analysis. bcl-2-Associated X Protein / analysis. bcl-X Protein / analysis

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 16136583.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein; 0 / bcl-X Protein
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15. Yu GY, Gao Y, Peng X, Chen Y, Zhao FY, Wu MJ: A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region. Int J Oral Maxillofac Surg; 2008 Nov;37(11):1003-8
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  • [Title] A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region.
  • Basaloid squamous cell carcinoma (BSCC) is a rare distinct variant of squamous cell carcinoma (SCC).
  • To investigate its clinical behavior and prognosis, 15 patients with BSCC in the oral and maxillofacial region were clinically analyzed and compared with 15 patients with conventional SCC matched for site, stage, gender and age.
  • CK 7, CK 8, proliferating cell nuclear antigen (PCNA) and p53 were reviewed from 12 patients with BSCC.
  • The rate of cervical lymph node metastasis of BSCC was as high as 67% and that of distant metastasis 13%.
  • In most BSCC patients (10/12) the PCNA index was over 50%.
  • Twelve BSCC patients were diagnosed with grade II or III conventional SCC when the original records of the primary diagnosis for the 15 patients with BSCC were reviewed.
  • The biological behavior and prognosis of BSCC are similar to those of poorly differentiated SCC.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Mouth Neoplasms / pathology. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Case-Control Studies. Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Proliferating Cell Nuclear Antigen / metabolism. Survival Rate


16. Bellizzi AM, Woodford RL, Moskaluk CA, Jones DR, Kozower BD, Stelow EB: Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. Am J Surg Pathol; 2009 Nov;33(11):1608-14
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  • [Title] Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers.
  • Basaloid squamous cell carcinoma (BSCC) of the esophagus is rare, historically confused for adenoid cystic carcinoma, and recently shown to behave similar to conventional, keratinizing esophageal squamous cell carcinoma.
  • At other sites (eg, oropharynx, anogenital tract) the basaloid phenotype is frequently associated with the presence of high-risk human papillomavirus (HPV).
  • HPVs role in esophageal squamous cell carcinomas is less certain, and to our knowledge, a direct examination of esophageal BSCC for high-risk HPV has not been performed earlier.
  • Nine cases of esophageal BSCC were retrieved from our surgical pathology files.
  • Twenty-two cases of keratinizing esophageal squamous cell carcinoma served as controls.
  • Compared with controls, BSCC showed less immunoreactivity for p16 and p53 (P=0.003, 0.009).
  • Esophageal BSCC is negative for high-risk HPV by ISH, distinguishing these lesions from other BSCCs.
  • Differential p16 and p53 expression in BSCC suggests that these tumors are molecularly distinct from conventional esophageal squamous cell carcinomas.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma, Basal Cell / virology. Carcinoma, Basosquamous / virology. Carcinoma, Squamous Cell / virology. Esophageal Neoplasms / virology. Papillomavirus Infections / complications


17. Alkan S, Coskun BU, Ugur S, Başak T, Dadas B: Basaloid squamous cell carcinoma of the larynx. Auris Nasus Larynx; 2006 Mar;33(1):71-4
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  • [Title] Basaloid squamous cell carcinoma of the larynx.
  • Basaloid squamous cell carcinoma (BSCC) is a rare tumor with distinct morphological and biological features that differentiate it from the common form of squamous cell carcinoma (SCC) in the head and neck region.
  • We present two cases of BSCC of the larynx; both being transglottic tumors.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16188414.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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18. Knopf A, Schneider J, Schipper J, Hoffmann TK, Bas M: [Sinonasal basaloid squamous cell carcinoma in biopsies of inverted papilloma]. HNO; 2008 Aug;56(8):808-12
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  • [Title] [Sinonasal basaloid squamous cell carcinoma in biopsies of inverted papilloma].
  • [Transliterated title] Das sinonasale basaloid-squamöse Karzinom in Biopsien eines invertierten Papilloms.
  • Basaloid squamous cell carcinoma (BSCC) is a rare tumor representing an aggressive variant of squamous cell carcinoma (SCC) and arising from a common precursor cell.
  • BSCC rarely originates from the sinonasal tract.
  • We report on an 83-year-old woman with BSCC after multiple resections of an inverted papilloma (IP) of the left sinonasal tract.
  • A possible association between sinonasal BSCC and IP, as implicated by the current case, must be further investigated.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Squamous Cell / pathology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 17876561.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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19. Hung JJ, Li AF, Liu JS, Lin YS, Hsu WH: Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma. Ann Thorac Surg; 2008 Mar;85(3):1102-4
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  • [Title] Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma.
  • It often presents as a large intraluminal polypoid tumor with early onset of symptoms resulting in prompt diagnosis.
  • We present here the first case of a carcinosarcoma of the esophagus that had a basaloid squamous cell carcinoma component in addition to the osteosarcoma and without a transitional zone.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinosarcoma / pathology. Esophageal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Osteosarcoma / pathology


20. Lu SY, Eng HL, Huang CC, Chien CY, Lui CC, Lin JW: Basaloid squamous cell carcinoma of the sinonasal tract: report of two cases. Otolaryngol Head Neck Surg; 2006 May;134(5):883-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the sinonasal tract: report of two cases.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Nose Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Fatal Outcome. Humans. Male

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  • (PMID = 16647553.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Klenzner T, Arapakis I, Kayser G, Boedeker CC: Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma. Otolaryngol Head Neck Surg; 2006 Jul;135(1):158-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma of the ear mimicking basaloid squamous cell carcinoma.
  • [MeSH-major] Acrospiroma / diagnosis. Carcinoma, Basosquamous / diagnosis. Ear, External. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16815204.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T: Histological diversity in basaloid squamous cell carcinoma of the esophagus. Dis Esophagus; 2009;22(3):231-8
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  • [Title] Histological diversity in basaloid squamous cell carcinoma of the esophagus.
  • Basaloid squamous cell carcinoma of the esophagus (BSCCE) is a distinct variant of esophageal cancer.
  • Histological features were classified into five components: solid nest (SN), microcyst and/or trabecular nest (MT), ductal differentiation (DD), cribriform pattern (CP), and an invasive squamous cell carcinoma (SCC) component.


23. Campos MS, Modolo F, de Oliveira JS, Pinto-Júnior DS, de Sousa SC: Atypical presentation of oral basaloid squamous cell carcinoma. J Contemp Dent Pract; 2009;10(2):98-104
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  • [Title] Atypical presentation of oral basaloid squamous cell carcinoma.
  • AIM: The purpose of this report is to present the clinical and histological features of a basaloid squamous cell carcinoma (BSCC) occurring in the retromolar trigone of a 59-year-old man and to relate its immunohistochemical characteristics.
  • BACKGROUND: BSCC is an aggressive distinct variant of squamous cell carcinoma (SCC) requiring recognition as a separate entity from SCC due to its peculiar behavior.
  • Histologically, nests and cords of closely packed, moderately pleomorphic basaloid cells with nuclear palisading along the periphery of the neoplastic nests surrounded by a fibrous stroma were found.
  • SUMMARY: Since this tumor can mimic other neoplasms such as adenoid cystic carcinoma, neuroendocrine carcinoma, and basal cell adenocarcinoma, histological features are essential to differentiate between them.
  • CLINICAL SIGNIFICANCE: BSCC needs to be differentiated from other neoplasms as early as possible because of its adverse prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Transitional Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Cell Nucleus / ultrastructure. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Keratins / analysis. Ki-67 Antigen / analysis. Laminin / analysis. Male. Middle Aged. Mitosis. Necrosis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 19279978.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Laminin; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
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24. Shima K, Muramatsu T, Abiko Y, Yamaoka Y, Sasaki H, Shimono M: Connexin 43 transfection in basaloid squamous cell carcinoma cells. Oncol Rep; 2006 Aug;16(2):285-8
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  • [Title] Connexin 43 transfection in basaloid squamous cell carcinoma cells.
  • To investigate the relationship between the expression of connexin in basaloid squamous cell carcinomas (BSCC) and their rapid proliferation and invasive potential, we examined the effect of overexpression of connexin 43 (Cx43) in a BSCC-derived cell line (BSC-OF).
  • In almost all of the clones, cell proliferation was clearly suppressed.
  • Furthermore, we investigated cell migration and invasion in three clones that showed a remarkable down-regulation in cell growth, and found that Cx43 transfection showed no significant effect on either.
  • However, no definite correlation was found between Cx43 and cell migration and invasion.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Proliferation. Connexin 43 / physiology
  • [MeSH-minor] Cell Movement / genetics. Cytoplasm / chemistry. Cytoplasm / metabolism. Humans. Neoplasm Invasiveness / genetics. Transfection. Tumor Cells, Cultured

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  • (PMID = 16820904.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Connexin 43
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25. Deniz K, Yüce I, Cağli S, Okten T, Güney E: Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: a controlled study. Ear Nose Throat J; 2008 Aug;87(8):469-73
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  • [Title] Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: a controlled study.
  • We investigated the difference in the biologic nature of typical squamous cell carcinoma (SCC) and basaloid SCC (BSCC) of the larynx by studying proliferation and antiapoptotic markers.
  • We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site-matched controls with typical laryngeal SCC.
  • Our findings indicate that the biologic nature of typical laryngeal SCC and laryngeal BSCC is similar.
  • In addition, our follow-up data suggest that the clinical course of laryngeal BSCC is no worse than that of typical laryngeal SCC.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Genes, bcl-2. Laryngeal Neoplasms / pathology. Proliferating Cell Nuclear Antigen / biosynthesis

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  • (PMID = 18712697.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proliferating Cell Nuclear Antigen
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26. Marioni G, Ottaviano G, Marchese-Ragona R, Giacomelli L, Bertolin A, Zanon D, Marino F, Staffieri A: High nuclear expression of the apoptosis inhibitor protein survivin is associated with disease recurrence and poor prognosis in laryngeal basaloid squamous cell carcinoma. Acta Otolaryngol; 2006 Feb;126(2):197-203
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  • [Title] High nuclear expression of the apoptosis inhibitor protein survivin is associated with disease recurrence and poor prognosis in laryngeal basaloid squamous cell carcinoma.
  • CONCLUSION: Nuclear expression of survivin should be studied as a promising marker of higher-risk laryngeal basaloid squamous cell carcinomas (BSCCs), which can then be treated more aggressively and followed more closely.
  • OBJECTIVE: BSCC is an uncommon bimorphic variant of SCC.
  • The hypothesized greater aggressiveness and poorer prognosis of head and neck BSCC compared to SCC are still under debate.
  • The regulation of apoptotic cell death has a profound effect on the pathogenesis and progression of malignancies.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basosquamous / metabolism. Laryngeal Neoplasms / metabolism. Microtubule-Associated Proteins / analysis. Neoplasm Proteins / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Apoptosis. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Case-Control Studies. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Prognosis

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  • (PMID = 16428200.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins
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27. Andreadis D, Nomikos A, Epivatianos A, Poulopoulos A, Barbatis C: Basaloid squamous cell carcinoma versus basal cell adenocarcinoma of the oral cavity. Pathology; 2005 Dec;37(6):560-3
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  • [Title] Basaloid squamous cell carcinoma versus basal cell adenocarcinoma of the oral cavity.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Oropharyngeal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry


28. Ozgursoy OB, Yorulmaz I, Tulunay O: Rapid and unusual spread of basaloid squamous cell carcinoma of the maxillary sinus. B-ENT; 2008;4(4):233-8
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  • [Title] Rapid and unusual spread of basaloid squamous cell carcinoma of the maxillary sinus.
  • Basaloid squamous cell carcinoma is a variant of epidermoid carcinoma with a morphology consisting of both basaloid and squamous cell components.
  • In this report, we present the aggressive course of a basaloid squamous cell carcinoma of the maxillary sinus in a 28-year-old patient who died only four months after the initial diagnosis.
  • [MeSH-major] Carcinoma, Basosquamous / secondary. Maxillary Sinus Neoplasms / pathology

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  • (PMID = 19227029.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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29. Karatzanis AD, Fragkiadakis GM, Prokopakis EP, Koutsopoulos AV, Helidonis ES, Velegrakis GA: Basaloid squamous cell carcinoma of the soft palate: case report. Auris Nasus Larynx; 2008 Dec;35(4):592-6
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  • [Title] Basaloid squamous cell carcinoma of the soft palate: case report.
  • Basaloid squamous cell carcinoma (BSCC) is a histologically distinct variant of squamous cell carcinoma.
  • The palate is a very rare site of BSCC development and only three cases have been reported in the international literature.
  • In this report, we present a case of basaloid squamous cell carcinoma of the soft palate.
  • The therapeutic strategy and histological findings are described in detail, including immunohistochemistry with the use of involucrin, an agent used for the first time for BSCC diagnosis.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Carcinoma, Squamous Cell / diagnosis. Palatal Neoplasms / diagnosis. Palate, Soft
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Coloring Agents. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Protein Precursors. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 18242906.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Protein Precursors; 60108-77-2 / involucrin
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30. Rau AR, Kini H, Naik R, Sahu KK: Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma. Indian J Pathol Microbiol; 2005 Jan;48(1):31-3
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  • [Title] Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma.
  • Basaloid squamous cell carcinoma (BSCC) is a high grade variant of Squamous Cell Carcinoma with a predilection for the aero-digestive tract.
  • The typical microscopic features of carcinoma with a basaloid pattern in intimate association with a squamous component helps in diagnosis of this tumour.
  • This study discusses the differential diagnosis of BSCC, as recognition of this tumour may have therapeutic implications.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology

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  • (PMID = 16758784.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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31. Nagakawa H, Hiroshima K, Takiguchi Y, Yatomi M, Takahashi Y, Mikami M, Nakatani Y, Kuriyama T: Basaloid squamous-cell carcinoma of the lung in a young woman. Int J Clin Oncol; 2006 Feb;11(1):66-8
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  • [Title] Basaloid squamous-cell carcinoma of the lung in a young woman.
  • We report a rare case of basaloid squamous cell carcinoma of the lung in a young Japanese woman.
  • Transbronchial fine-needle aspiration cytology supported a tentative diagnosis of primary squamous-cell carcinoma of the lung.
  • Necropsy established the diagnosis of basaloid squamous-cell carcinoma of the lung.
  • This is the youngest patient with a case of basaloid squamous cell carcinoma of the lung ever reported.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Lung Neoplasms / diagnosis

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  • [Cites] Am J Surg Pathol. 1998 Oct;22(10):1267-76 [9777989.001]
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  • (PMID = 16508733.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Soriano E, Faure C, Lantuejoul S, Reyt E, Bolla M, Brambilla E, Righini CA: Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case-control study of 62 patients. Eur J Cancer; 2008 Jan;44(2):244-50
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  • [Title] Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case-control study of 62 patients.
  • OBJECTIVE: To describe the natural history and evaluate the prognosis of basaloid squamous cell carcinoma (BSCC) of the upper aero-digestive tract as compared to the usual squamous cell carcinoma (SCC).
  • MATERIALS AND METHODS: Sixty-two patients with BSCC and 62 patients with SCC were matched with regards to TNM classification, localisation and therapeutic modalities.
  • RESULTS: Survival rates were significantly higher in patients with SCC as compared to patients with BSCC.
  • The rate of distant metastasis was six times higher in cases of BSCC, which was the major cause of mortality.
  • CONCLUSION: This study reveals that BSCC has distinct histo-pathologic features and an aggressive clinical course, justifying its consideration as a separate entity with poor prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Head and Neck Neoplasms / mortality

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  • (PMID = 18096379.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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33. Valeri RM, Kaplanis K, Apostolou T, Kiziridou A, Pantidou A, Boussoulegas A, Destouni Ch: Basaloid squamous cell carcinoma of the uterine cervix with an uncommon metastasis to the left iliac region--case report. Eur J Gynaecol Oncol; 2006;27(6):625-8
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  • [Title] Basaloid squamous cell carcinoma of the uterine cervix with an uncommon metastasis to the left iliac region--case report.
  • We describe a rare and interesting case of a basaloid squamous cell carcinoma (BSC) of the uterine cervix with metastasis in the left iliac region diagnosed by fine needle aspiration (FNA).
  • The material was processed by conventional liquid based cytology (ThinPrep), and by the cell-block technique and diagnosis was based on the cytomorphologic and immunochemical characteristics as well as the patient's history.
  • The cytologic diagnosis concerned a poorly differentiated squamous cell carcinoma.
  • The histological diagnosis then was an "infiltrative squamous cell carcinoma of basaloid type" of the uterine cervix.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Pelvic Neoplasms / secondary. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasms, Basal Cell / secondary. Neoplasms, Basal Cell / therapy

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  • (PMID = 17290600.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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34. Soriano E, Righini Ch, Faure C, Lantuejoul S, Colonna M, Bolla M, Brambilla E, Reyt E: [Course and prognosis of basaloid squamous cell carcinoma: case-control study of 49 patients]. Ann Otolaryngol Chir Cervicofac; 2005 Sep;122(4):173-80
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  • [Title] [Course and prognosis of basaloid squamous cell carcinoma: case-control study of 49 patients].
  • INTRODUCTION: The course and prognosis of basaloid squamous cell carcinoma (BSCC) are not well known.
  • OBJECTIVES: To study the course and prognosis in a population of BSCC patients.
  • MATERIALS AND METHODS: We analyzed a retrospective cohort of 49 patients with BSCC in comparison with a cross-matched population of 49 patients treated for well- to moderately differentiated squamous cell carcinoma (SCC).
  • RESULTS: The statistical analysis showed that survival in BSCC group was lower than in the SCC group.
  • Local recurrence in the BSCC group was not higher than in the SCC group, but mortality by distant metastasis was six times higher than in the SCC population.
  • CONCLUSIONS: We consider BSCC patients as a high-risk population and we complete diagnosis explorations including a FDG-PET before curative treatment.
  • [MeSH-major] Carcinoma, Basosquamous. Head and Neck Neoplasms
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Case-Control Studies. Cohort Studies. Female. France / epidemiology. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 16230937.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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35. Begum S, Westra WH: Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol; 2008 Jul;32(7):1044-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status.
  • Basaloid squamous cell carcinoma (BSCC) of the head and neck is set apart as a distinct subtype of squamous cell carcinoma on the basis of its basaloid appearance and aggressive behavior.
  • The purpose of this study was to determine whether BSCC could be further subdivided on the basis of human papillomavirus 16 (HPV16) status.
  • The absence of HPV16 was significantly associated with decreased overall survival (Hazard ratio=17.1; 95% confidence interval=7.2-40.3, log-rank P=0.0001), even though patients with HPV16-positive carcinomas were more likely to present with lymph nodes metastases (P=0.01, Fisher exact).
  • Morphologic similarities aside, BSCCs are composed of a mixed group of tumors that can be separated on the basis of HPV16 status.
  • HPV16-positivity in squamous cell carcinomas of the head and neck is now recognized as a powerful indicator of improved patient survival.
  • HPV16 detection thus permits resolution of a less aggressive component within a high-grade subtype of head and neck carcinoma.
  • [MeSH-major] Carcinoma, Basosquamous / secondary. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections / pathology

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  • (PMID = 18496144.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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36. Lee JS, Ko IJ, Jun SY, Kim JY: Basaloid squamous cell carcinoma in nasal cavity. Clin Exp Otorhinolaryngol; 2009 Dec;2(4):207-10

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  • [Title] Basaloid squamous cell carcinoma in nasal cavity.
  • Basaloid squamous cell carcinoma (BSCC) is often founded in the head and neck region.
  • However, BSCC in the sinonasal tract is rare.
  • Histopathologic examination of the excised tumor confirmed BSCC in the nasal cavity.
  • We report here on a nasal cavity BSCC that was treated with partial maxillectomy only.

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  • [Cites] Otolaryngol Head Neck Surg. 2006 May;134(5):883-5 [16647553.001]
  • [Cites] Am J Otolaryngol. 1994 May-Jun;15(3):204-11 [8024109.001]
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  • (PMID = 20072697.001).
  • [ISSN] 2005-0720
  • [Journal-full-title] Clinical and experimental otorhinolaryngology
  • [ISO-abbreviation] Clin Exp Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2804098
  • [Keywords] NOTNLM ; Basaloid squamous cell carcinoma / Maxillectomy / Sinonasal tract
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37. Akagi I, Miyashita M, Makino H, Nomura T, Ohkawa K, Tajiri T: Basaloid squamous cell carcinoma of the esophagus: report of two cases. J Nippon Med Sch; 2008 Dec;75(6):354-60
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  • [Title] Basaloid squamous cell carcinoma of the esophagus: report of two cases.
  • Basaloid squamous cell carcinoma is an uncommon malignancy of the esophagus.
  • We present two cases of basaloid squamous carcinoma of the esophagus.
  • Both tumors histologically consisted of solid cell nests and displayed focal immunoreactivity for type IV collagen.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Esophageal Neoplasms / pathology

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  • (PMID = 19155575.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Cabanillas R, Rodrigo JP, Ferlito A, Rinaldo A, Fresno MF, Aguilar C, Alvarez ME, Suárez C: Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx? Oral Oncol; 2007 Apr;43(4):327-32
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  • [Title] Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx?
  • The epidemiological link between human papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied.
  • The tobacco and alcohol consumption and the clinical outcomes of nine patients with BSCC of the pharynx are compared with site and stage matched 109 conventional squamous cell carcinoma (SCC) patients.
  • The BSCC specimens were analyzed for the presence of HPV DNA and p53 expression.
  • We did not find any significant differences in tobacco and alcohol consumption between patients with BSCC and patients with SCC.
  • No HPV DNA was detected in BSCC, and p53 overexpression was found in five (55%) of the cases.
  • Our results do not support an etiological link between HPV DNA and BSCC.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. DNA, Viral / biosynthesis. Papillomaviridae / genetics. Pharyngeal Neoplasms / epidemiology

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  • (PMID = 16979930.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Tumor Suppressor Protein p53
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39. Ereño C, Gaafar A, Garmendia M, Etxezarraga C, Bilbao FJ, López JI: Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature. Head Neck Pathol; 2008 Jun;2(2):83-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature.
  • Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of cancer that mainly arises in the upper aerodigestive tract.
  • The basaloid component predominated in 29 cases (72.5%).
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Mouth Neoplasms / diagnosis. Otorhinolaryngologic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Hypopharyngeal Neoplasms / diagnosis. Hypopharyngeal Neoplasms / mortality. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / mortality. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Neoplasms, Multiple Primary. Oropharyngeal Neoplasms / diagnosis. Oropharyngeal Neoplasms / mortality. Survival Rate

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  • (PMID = 20614328.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807543
  • [Keywords] NOTNLM ; Basaloid-squamous cell carcinoma / Differential diagnosis / Head and neck / Hypopharynx / Larynx / Metastasis / Oral cavity / Oropharynx / Prognosis / Recurrence
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40. Chatelain D, Mokrani N, Fléjou JF: [Anal and anal margin tumors]. Ann Pathol; 2007 Dec;27(6):459-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cancers are infrequent and consisted of well-differentiated squamous cell carcinoma, or poorly differentiated basaloid squamous cell carcinoma.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Endocrine Gland Neoplasms / epidemiology. Endocrine Gland Neoplasms / pathology. France / epidemiology. Humans. Incidence. Leiomyosarcoma / pathology. Lymphoma / pathology. Melanoma / epidemiology. Melanoma / pathology. Papilloma / pathology. Sarcoma, Kaposi / pathology

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  • (PMID = 18554556.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 110
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41. Shibata Y, Baba E, Ariyama H, Miki R, Ogami N, Arita S, Qin B, Kusaba H, Mitsugi K, Noshiro H, Yao T, Nakano S: Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin. World J Gastroenterol; 2007 Jul 14;13(26):3634-7
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  • [Title] Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin.
  • Basaloid squamous cell carcinoma (BSC) of the esophagus is a rare malignant disease.
  • A 57-year-old woman was diagnosed as having squamous cell carcinoma of the esophagus upon endoscopic examination.
  • The pathological diagnosis of the surgical specimen was BSC.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Esophageal Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 17659717.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC4146806
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42. Rodríguez Tojo MJ, García Cano FJ, Infante Sánchez JC, Velázquez Fernández E, Aguirre Urízar JM: Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx. Clin Transl Oncol; 2005 Apr;7(3):110-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx.
  • INTRODUCTION: Basaloid is a rare and poorly-differentiated variant of squamous cell carcinoma of the larynx, with an invasive solid growth of cells in a lobular configuration.
  • OBJECTIVE: To evaluate the relationship between the immunoexpression of p53, Ki-67 and E-cadherin in relation to prognosis in basaloid squamous cell carcinoma of the larynx (BSCCL).
  • CONCLUSIONS: BSCCL is an aggressive variant of the squamous cell carcinoma and has a high expression of p53 and Ki-67 with a low expression of Ecadherin.
  • [MeSH-major] Cadherins / biosynthesis. Carcinoma, Squamous Cell / immunology. Ki-67 Antigen / biosynthesis. Laryngeal Neoplasms / immunology. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 15899218.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Cadherins; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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43. Quintyn-Ranty ML, Escourrou G, Guilbeau C, Rimailho J, Delisle MB: [Vaginal adenoid cystic carcinoma: a case report]. Ann Pathol; 2008 Apr;28(2):135-7
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  • [Title] [Vaginal adenoid cystic carcinoma: a case report].
  • Adenoid cystic carcinoma generally arises from the salivary glands and is rarely found in the female genital tract.
  • Differential diagnosis includes adenoid basal carcinoma, polymorphous low-grade adenocarcinoma and basaloid squamous cell carcinoma.
  • We report a case of adenoid cystic carcinoma in a 48-year-old woman with previous cervical HPV infection.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18675169.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Actins
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44. Záruba K, Králová J, Rezanka P, Poucková P, Veverková L, Král V: Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy. Org Biomol Chem; 2010 Jul 21;8(14):3202-6
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  • Two porphyrin-brucine quaternary ammonium salts were immobilized on gold nanoparticles and their suitability for both in vitro and in vivo photodynamic therapy (PDT) was assayed using the basaloid squamous cell carcinoma PE/CA-PJ34 cell line.
  • [MeSH-minor] Alkylation. Animals. Biological Transport. Cell Death / drug effects. Cell Death / radiation effects. Cell Line, Tumor. Humans. Intracellular Space / metabolism. Mice. Neoplasms / drug therapy. Solvents / chemistry

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  • (PMID = 20485822.001).
  • [ISSN] 1477-0539
  • [Journal-full-title] Organic & biomolecular chemistry
  • [ISO-abbreviation] Org. Biomol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Porphyrins; 0 / Solvents; 6NG17YCK6H / brucine; 7440-57-5 / Gold; H9Y79VD43J / Strychnine
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45. Marioni G, Gaio E, Giacomelli L, Marchese-Ragona R, Staffieri C, Staffieri A, Marino F: Endoglin (CD105) expression in head and neck basaloid squamous cell carcinoma. Acta Otolaryngol; 2005 Mar;125(3):307-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoglin (CD105) expression in head and neck basaloid squamous cell carcinoma.
  • OBJECTIVE: Basaloid squamous cell carcinoma (BSCC) is an uncommon, high-grade biomorphic variant of SCC with a predilection for the head and neck region.
  • It is a matter of controversy whether the biological and clinical behaviour of BSCC is more aggressive than that of SCC.
  • [MeSH-major] Carcinoma, Basosquamous / metabolism. Carcinoma, Squamous Cell / metabolism. Head and Neck Neoplasms / metabolism. Vascular Cell Adhesion Molecule-1 / metabolism
  • [MeSH-minor] Adult. Aged. Antigens, CD. Biomarkers, Tumor / metabolism. Case-Control Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neovascularization, Pathologic / metabolism. Receptors, Cell Surface

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  • (PMID = 15966703.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / ENG protein, human; 0 / Receptors, Cell Surface; 0 / Vascular Cell Adhesion Molecule-1
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46. Stelow EB, Mills SE: Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol; 2005 Dec;124 Suppl:S96-109
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma variants of the upper aerodigestive tract.
  • Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract.
  • In such cases, correct diagnosis is important for prognostic and therapeutic reasons.
  • This article discusses the clinicopathologic features of the upper aerodigestive tract variants of SCC, including verrucous carcinoma, papillary squamous cell carcinoma, basaloid squamous cell carcinoma, spindle cell carcinoma, adenosquamous carcinoma, adenoid squamous cell carcinoma, and undifferentiated carcinoma.
  • It also discusses the differential diagnoses that must be considered and the use of ancillary testing, especially immunohistochemical analysis, for determining the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Digestive System Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Papillary / pathology. Humans

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  • (PMID = 16468420.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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47. Niimi S, Satou B, Asaoka M: [Pleomorphic carcinoma; report of a case]. Kyobu Geka; 2010 Jun;63(6):489-91
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  • [Title] [Pleomorphic carcinoma; report of a case].
  • We experienced a case of pulmonary pleomorphic carcinoma.
  • For the shadow was strongly suspisious for lung carcinoma left lower lobectomy was performed.
  • The resected tumor was composed of spindle cell component and basaloid squamous cell carcinoma component indicating unusual pulmonary pleomorphic carcinoma.
  • [MeSH-major] Carcinoma / pathology. Lung Neoplasms / pathology

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  • (PMID = 20533742.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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48. Ooi CG, James CL, Huilgol SC: Metastatic Bowen carcinoma. Australas J Dermatol; 2006 Nov;47(4):277-80
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • [Title] Metastatic Bowen carcinoma.
  • A 72-year-old man presented with basaloid squamous cell carcinoma metastatic to both lungs that was morphologically similar to recurrent, invasive moderately to poorly differentiated carcinoma arising from persistent Bowen's disease of the right cheek.
  • The original lesion of invasive moderately differentiated squamous cell carcinoma arising in Bowen's disease had been excised 11 years previously.
  • He died of respiratory failure 19 months following diagnosis of his metastatic disease.
  • Our case reflects the potentially aggressive nature of invasive squamous cell carcinoma arising from Bowen's disease and highlights the importance of approaching this entity with a view to complete surgical excision with adequate margins.
  • [MeSH-major] Bowen's Disease / diagnosis. Lung Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cheek / pathology. Diagnosis, Differential. Fatal Outcome. Humans. Male. Neoplasm Metastasis

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  • (PMID = 17034472.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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49. Kusafuka K, Asano R, Kamijo T, Iida Y, Onitsuka T, Kameya T, Nakajima T: Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis. Int J Oral Maxillofac Surg; 2009 Mar;38(3):296-9
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  • [Title] Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis.
  • A case of large cell neuroendocrine carcinoma (LCNEC) of the tongue base is described.
  • It was characterized by solid tumor nests with central necrosis and rosette formation resembling basaloid squamous cell carcinoma.
  • Basal cells in the normal squamous epithelium around the tumor indicated positivity for neural cell adhesion molecule and N-cadherin.
  • These cells were considered neuroendocrine-related cells in the lingual squamous epithelium, which are related to the tumorigenesis of mucosal LCNEC in the tongue base.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, Neoplasm / immunology. Diagnosis, Differential. Humans. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / surgery. Immunohistochemistry. Male. Treatment Outcome

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  • (PMID = 19167190.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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50. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C: Basal cell adenoma of the parotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E206-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland. Case report and review of the literature.
  • Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma.
  • Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is mandatory.
  • We describe a case of basal cell adenoma of the parotid gland.
  • We also review the literature and discuss the diagnosis and management of this rare entity.

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  • (PMID = 16505803.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 21
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51. Wang P, Zhang G, Shen H: Multiple synchronous primary malignancies induced by benzene exposure: a case report. J Occup Med Toxicol; 2009;4:7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 40 years later, this patient developed three synchronous primary neoplasms with three different histologies including a basaloid squamous cell carcinoma of the esophagus, primary hepatocellular carcinoma, and well-differentiated squamous cell carcinoma of the gum.

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  • (PMID = 19371416.001).
  • [ISSN] 1745-6673
  • [Journal-full-title] Journal of occupational medicine and toxicology (London, England)
  • [ISO-abbreviation] J Occup Med Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2674456
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52. Friedrich RE, Sperber C, Jäkel T, Röser K, Löning T: Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression. Anticancer Res; 2010 May;30(5):1605-12
MedlinePlus Health Information. consumer health - Oral Cancer.

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  • [Title] Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression.
  • Basaloid squamous cell carcinoma is a variant of squamous cell carcinoma, preferentially arising in the head and neck region.
  • Current reports point to an association of basaloid squamous cell carcinoma (BSCC) and human papilloma virus (HPV) infection.
  • The aim of this study was to analyse the HPV infection status in different entities of oral neoplasms or dysplasias with basaloid differentiation of epithelial cells.
  • MATERIALS AND METHODS: The study comprised data from 34 oral lesions of squamous epithelial origin: 17 BSCCs, 10 papillomas and 7 hyperplasias/dysplasias of oral epithelia.
  • RESULTS: The rate of HPV-infected BSCC was extraordinarily high.
  • The infection status differed significantly between BSCC and other oral lesions in terms of frequency of HPV infection and HPV genotypes. p16 expression proved not to be a suitable surrogate marker of HPV high-risk infection in oral lesions, in particular in BSCC.
  • This was an essential difference of this collective compared to genital carcinomas with HPV high-risk infections.
  • CONCLUSION: This study revealed a high association between BSCC and HPV type 16.
  • Type-specific analysis of HPV infection in head and neck cancer may be important in the differential diagnosis of malignancies in the head and neck region with a basaloid growth pattern.
  • A simplified test for HPV in BSCC of the oral cavity using the immunohistochemical proof of p16 expression as a surrogate marker is non-effective.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / virology. Epithelial Cells / metabolism. Epithelial Cells / virology. Gene Expression Regulation, Viral. Mouth Neoplasms / metabolism. Mouth Neoplasms / virology. Neoplasm Proteins / metabolism. Papillomavirus Infections / metabolism

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  • (PMID = 20592349.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / P16 protein, human
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53. Altrabulsi B, Carrizo F, Luna MA: Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases. Ann Diagn Pathol; 2006 Jun;10(3):149-53

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  • [Title] Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases.
  • We describe the clinicopathological and immunohistochemical features of three spindle (sarcomatoid) basaloid squamous carcinomas in three men aged 73, 69, and 59 years with a history of tobacco and alcohol abuse.
  • Histologically, they were composed of conventional basaloid squamous carcinomas with extensive malignant spindle cell proliferation, comprising more than 50% of the tumor.
  • One case in addition expressed CD99 and Bcl-2 and was originally diagnosed as monophasic synovial sarcoma; however, a subsequent biopsy disclosed basaloid squamous cell carcinoma with sarcomatoid stroma.
  • The patients were alive 14 (case patient 1), 10 (case patient 2), and 8 (case patient 3) months after diagnosis.
  • In the absence of evidence from immunohistochemical or electron microscopy studies, a polypoid malignant spindle cell tumor of a mucosal surface of the upper aerodigestive tract should be considered a sarcomatoid carcinoma until proven otherwise.
  • The type of epithelial component would determine the subtype of sarcomatoid carcinoma.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology. Hypopharynx / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 16730309.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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54. Zhang S, Bao R, Bagby J, Abreo F: Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol; 2009 Jul-Aug;53(4):375-82
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  • There were 5 false negatives: 2 adenoid cystic carcinomas, 1 acinic cell carcinoma, 1 polymorphous low grade adenocarcinoma and 1 metastatic basaloid squamous cell carcinoma.
  • The only false positive was a pleomorphic adenoma misdiagnosed as adenoid cystic carcinoma.
  • CONCLUSION: Our results are consistent with the literature that salivary gland FNA has good sensitivity, specificity and accuracy in the diagnosis of salivary neoplasms.

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  • (PMID = 19697720.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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55. Chapman-Fredricks J, Jorda M, Gomez-Fernandez C: A limited immunohistochemical panel helps differentiate small cell epithelial malignancies of the sinonasal cavity and nasopharynx. Appl Immunohistochem Mol Morphol; 2009 May;17(3):207-10
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  • [Title] A limited immunohistochemical panel helps differentiate small cell epithelial malignancies of the sinonasal cavity and nasopharynx.
  • BACKGROUND: Distinguishing small cell epithelial malignancies of the sinonasal cavity and nasopharynx is difficult due to overlapping morphologic characteristics, particularly in small biopsies.
  • The aim of this study is to identify a limited immunohistochemical panel that may help to differentiate these morphologically similar small cell epithelial malignancies.
  • DESIGN: We reviewed 37 cases of histologically similar small cell epithelial malignancies of the sinonasal cavity and nasopharynx: nasopharyngeal carcinoma (NPC) (16), basaloid squamous cell carcinoma (BSCC) (15), and high-grade neuroendocrine carcinoma (HGNEC) (6) obtained at Jackson Memorial Hospital/UM Sylvester Comprehensive Cancer Center between 2003 and 2007.
  • Immunohistochemistry for HLA-DR was positive in all cases of NPC, whereas BSCC and HGNEC were uniformly negative.
  • Cases of NPC and BSCC were positive for CK5/6 whereas cases of HGNEC were negative.
  • CONCLUSIONS: A limited immunohistochemical panel of CK, CK5/6, p63, and HLA-DR is useful in discriminating nasopharyngeal, basaloid squamous cell, and high-grade neuroendocrine carcinomas of the sinonasal cavity and nasopharynx.

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  • (PMID = 19077909.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / HLA-DR Antigens; 0 / Keratin-5; 0 / Keratin-6; 0 / Membrane Proteins
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56. Chen JX, Tang Q, Zhu HN, Zheng YD: [Diagnosis and treatment of basaloid squamous cell carcinoma of the esophagus]. Zhonghua Zhong Liu Za Zhi; 2008 May;30(5):392-5
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  • [Title] [Diagnosis and treatment of basaloid squamous cell carcinoma of the esophagus].
  • OBJECTIVE: To investigate the histopathological features of basaloid squamous cell carcinoma of the esophagus, and to explore the ways of its diagnosis, differential diagnosis and treatment.
  • METHODS: The clinical data and pathological features of 23 cases of esophageal basaloid squamous cell carcinoma were reviewed and analyzed retrospectively.
  • CONCLUSION: The basaloid squamous cell carcinoma of the esophagus is highly malignant with poor prognosis.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Carcinoma, Basosquamous / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy. Esophagus / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / diagnosis. Cisplatin / administration & dosage. Combined Modality Therapy. Diagnosis, Differential. Esophagectomy / methods. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Middle Aged. Radiotherapy, High-Energy. Retrospective Studies. Survival Rate

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  • (PMID = 18953844.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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57. Mendelsohn AH, Lai CK, Shintaku IP, Elashoff DA, Dubinett SM, Abemayor E, St John MA: Histopathologic findings of HPV and p16 positive HNSCC. Laryngoscope; 2010 Sep;120(9):1788-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Human papilloma virus (HPV) and p16INKa (p16) positivity in head and neck squamous cell carcinomas (HNSCCs) is currently thought to be an encouraging prognostic indicator.
  • Specified pathologic features were examined: perivascular invasion (PVI), perineural invasion (PNI), grade of squamous differentiation, basaloid classification.
  • However, HPV and p16 were strongly predictive of poorly differentiated tumors, as well as basaloid squamous cell carcinoma (SCCA) (P < .001).
  • CONCLUSIONS: HPV(+) and p16(+) are highly predictive for poorly differentiated tumors and basaloid SCCA.

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  • (PMID = 20803740.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / P16 protein, human
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58. Joshi D, Shivkumar VB, Sharma SM, Gangane N: Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report. Acta Cytol; 2009 Jan-Feb;53(1):89-92
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  • [Title] Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report.
  • BACKGROUND: Basaloid squamous cell carcinoma is a high-grade variant of squamous cell carcinoma that most commonly occurs in the upper aerodigestive tract.
  • The authors describe the cytologic features of a histologically confirmed case of basaloid squamous cell carcinoma arising in the floor of the mouth.
  • Extracellular basement membrane-like material was also noted, which led to the erroneous diagnosis of adenoid cystic carcinoma.
  • Histopathology characteristically revealed the presence of squamoid nests between malignant basaloid cells, and the tumor was finally diagnosed as basaloid squamous cell carcinoma.
  • CONCLUSION: Basaloid squamous cell carcinoma should be considered in the differential diagnosis of tumors arising in oral cavity.
  • Cytologic diagnosis may be difficult, but careful search for a second cell population of squamoid cells in addition to small basaloid cells may aid in rendering the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Middle Aged

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  • (PMID = 19248560.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Koutis EV, Assimakopoulos DA, Doukas MG, Zinovieva I: A rare nasal tip skin metastasis of a basaloid squamous cell carcinoma of the larynx. Am J Med; 2008 Sep;121(9):e3-4
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  • [Title] A rare nasal tip skin metastasis of a basaloid squamous cell carcinoma of the larynx.
  • [MeSH-major] Carcinoma, Basosquamous / secondary. Laryngeal Neoplasms / pathology. Nose Neoplasms / secondary

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  • (PMID = 18724953.001).
  • [ISSN] 1555-7162
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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60. Kwon YS, Kim YM, Choi GW, Kim YT, Nam JH: Pure basaloid squamous cell carcinoma of the uterine cervix: a case report. J Korean Med Sci; 2009 Jun;24(3):542-5
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  • [Title] Pure basaloid squamous cell carcinoma of the uterine cervix: a case report.
  • Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare malignancy of the female genital tract with a poorer clinical outcome than squamous cell carcinoma of the uterine cervix.
  • We report a case of pure basaloid squamous cell carcinoma of the uterine cervix.
  • A basaloid squamous cell carcinoma of the uterine cervix, of International Federation of Gynecology and Obstetrics (FIGO) stage Ib1, was diagnosed by a loop electrosurgical excision procedure cone biopsy.
  • Pathologic findings were consistent with a basaloid squamous cell carcinoma confined to the cervix without an extracervical tumor.
  • Although basaloid squamous cell carcinoma of the uterine cervix is thought to behave aggressively, accumulation of data on these rare tumors is necessary to determine whether their behavior differs significantly from that of conventional cervical squamous cell carcinoma of similar clinical stage.
  • These data would be useful for defining the best diagnosis and treatment for these rare tumors.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 19543425.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2698210
  • [Keywords] NOTNLM ; Basaloid / Carcinoma, Squamous Cell / Cervix Uteri
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61. Cakir E, Demirag F, Ucoluk GO, Kaya S, Memis L: Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation. Lung Cancer; 2007 Jul;57(1):109-11
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  • [Title] Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation.
  • Basaloid squamous cell carcinoma of the lung, an uncommon subtype of non-small cell carcinomas was introduced as a distinct entity in the recently revised World Health Organization (WHO) classification of lung tumours.
  • We report a 23-years-old female patient with basaloid squamous cell carcinoma of the lung who was stage IIB post-operatively.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 17328988.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 68238-35-7 / Keratins
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62. Hagemann IS, Lu J, Lewis JS Jr: Basaloid squamous cell carcinoma arising in [corrected] the renal pelvis. Int J Surg Pathol; 2008 Apr;16(2):199-201
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  • [Title] Basaloid squamous cell carcinoma arising in [corrected] the renal pelvis.
  • Basaloid squamous cell carcinoma is an uncommon and highly aggressive variant that can occur anywhere squamous cancers occur.
  • In this article, we report the first known case of basaloid squamous cell carcinoma arising in the renal pelvis.
  • Given the aggressive nature of this neoplasm, it should not be omitted from the differential diagnosis of neoplasms arising from the urothelium.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Kidney Neoplasms / pathology. Kidney Pelvis / pathology

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  • [ErratumIn] Int J Surg Pathol.2008 Jul;16(3);355
  • (PMID = 18417681.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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63. Díaz de Liaño A, Olivera E, Yárnoz C, García-Bragado F, Ortiz H: [Multifocal basaloid squamous carcinoma of the esophagus]. Cir Esp; 2007 Dec;82(6):358-60
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  • [Title] [Multifocal basaloid squamous carcinoma of the esophagus].
  • [Transliterated title] Carcinoma basaloide escamoso multifocal de esófago.
  • Basaloid-squamous carcinoma is a poorly-differentiated variety of squamous cell carcinoma.
  • We present a case of basaloid-squamous cell of the esophagus a 54 year-old man who underwent an esophagectomy with lymphadenectomy and has been followed-up for 5 years with no evidence of disease recurrence.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology

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  • (PMID = 18053506.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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64. Takemura M, Morimura K, Yoshida K, Fujiwara Y: [Four resected cases with basaloid carcinoma of esophagus--comparison of 5-FU-related enzymes (thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT)) between basaloid carcinoma and squamous cell carcinoma]. Gan To Kagaku Ryoho; 2010 Nov;37(11):2143-6
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  • [Title] [Four resected cases with basaloid carcinoma of esophagus--comparison of 5-FU-related enzymes (thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT)) between basaloid carcinoma and squamous cell carcinoma].
  • We reported herein four resected cases with basaloid carcinoma of the esophagus and measured the activity of 5-FU related enzymes (TS, DPD, OPRT) in cancer tissue.
  • These activities compared with those in squamous cell carcinoma.
  • Only one case was diagnosed as basaloid carcinoma by preoperative biopsy specimen at endoscopic examination.
  • DPD activity and OPRT activity showed no difference between squamous cell carcinoma and basaloid carcinoma.
  • On the other hand, the TS activity was significantly higher in basaloid carcinoma.
  • From the standpoint of 5-FU-related enzyme activities, basaloid carcinoma possibly has more resistance to 5-FU than squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / enzymology. Carcinoma, Squamous Cell / enzymology. Dihydrouracil Dehydrogenase (NADP) / metabolism. Esophageal Neoplasms / enzymology. Orotate Phosphoribosyltransferase / metabolism. Thymidylate Synthase / metabolism

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  • (PMID = 21084814.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; EC 1.3.1.2 / Dihydrouracil Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; EC 2.4.2.10 / Orotate Phosphoribosyltransferase; U3P01618RT / Fluorouracil
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65. Thariat J, Badoual C, Faure C, de Mones E, Butori C, Santini J, Poissonnet G, Maingon P, Faivre S, Klijanienko J, Saint-Guily JL, Righini CA, Groupe Refcor (Réseau d'Expertise Français sur les Cancers ORL Rares): [Basaloid squamous cell carcinomas of the head and neck]. Bull Cancer; 2009 Oct;96(10):989-1004
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  • [Title] [Basaloid squamous cell carcinomas of the head and neck].
  • Basaloid squamous cell carcinomas (SCC) are a rare variant of SCC of the head and neck.
  • A poorer prognosis of BSCC has been reported.
  • Conversely, BSCC have similar or better locoregional control rates, a relatively good radiosensitivity and locoregional control.
  • Some subgroups of BSCC (oropharynx in particular) are more likely to be associated with oncogenic human papilloma virus HPV16.
  • The determination of BSCC head and neck subgroups by HPV status is critical for the prognosis.
  • The basaloid sub-type of squamous cell carcinomas owing to its particular behavior, should be taken into account while deciding the optimal therapeutic strategy.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Combined Modality Therapy / methods. Diagnosis, Differential. Humans. Papillomavirus Infections / complications. Papillomavirus Vaccines / administration & dosage. Prognosis. Radiotherapy

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  • (PMID = 19793686.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Papillomavirus Vaccines
  • [Number-of-references] 69
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66. Subramanian B, Agrawal K, Panda K: Basaloid squamous carcinoma of mandible. J Craniofac Surg; 2009 Jan;20(1):151-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous carcinoma of mandible.
  • Basaloid squamous carcinoma is a rare distinct histologic variant of squamous cell carcinoma of the head and neck region.
  • Basaloid squamous carcinoma is more aggressive and has a poorer prognosis, although histologically, it is associated with squamous cell carcinoma and squamous atypia.
  • The usual site of occurrence for basaloid squamous carcinoma is the base of the tongue, hypopharynx (pyriform sinus), and the supraglottic larynx (Wain et al.
  • We are reporting an unusual case of basaloid squmous carcinoma of the mandible with no secondaries and features of sarcomatoid pattern histologically.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mandibular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Biopsy, Fine-Needle. Bone Wires. Female. Follow-Up Studies. Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Humans. Neck Dissection. Radiography, Panoramic. Radiotherapy, Adjuvant

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  • (PMID = 19165013.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Winters R, Naud S, Evans MF, Trotman W, Kasznica P, Elhosseiny A: Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases. Head Neck Pathol; 2008 Dec;2(4):265-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases.
  • Diagnosis of basaloid squamous carcinoma (BSCC) currently relies mainly on histological criteria, with variable immunohistochemical results reported in small series.
  • We explored the use of a battery of immunohistochemical stains to elucidate this diagnosis on 45 cases of BSCC.
  • To further elucidate the immunohistochemical profile of BSCC, to explore potential genetic pathways of malignant transformation using proliferation markers, and to investigate a possible link with Human Papillomavirus (HPV).
  • Forty-five cases of BSCC and 34 site-matched cases of squamous cell carcinoma (SCC) were obtained from the archives of the pathology department at our institution.
  • Ber-EP4 is a useful diagnostic marker for BSCC, positive in 82% (37/45) of the cases and in 68% (23/34) of SCC.
  • An alternative is the combination of cytokeratins CK14 and CK7, known to be negative, and CK1, known to be positive, which achieves an accuracy of 73% (33/45) in BSCC and 88% (30/34) in SCC.
  • Increased expression of the proliferation markers supports the concept that BSCC is a rapidly growing tumor.
  • Results of p16 stains support an etiological link between BSCC and HPV; interestingly, HPV was present significantly more in BSCC (71% (32/45)), than in SCC (59% (20/34)) in this study (P=0.02).

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  • (PMID = 20614292.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] ENG
  • [Grant] United States / PHS HHS / / 22435-22
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Viral; 0 / Keratin-1; 0 / Keratin-14; 0 / Keratin-7; 0 / human epithelial antigen-125
  • [Other-IDs] NLM/ PMC2807584
  • [Keywords] NOTNLM ; Basaloid squamous carcinoma / Basosquamous carcinoma / Immunohistochemistry / Squamous cell carcinoma
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68. Hirai K, Koizumi K, Hirata T, Yamagishi S, Shimizu K, Kawamoto M: Basaloid carcinoma of the lung. Jpn J Thorac Cardiovasc Surg; 2005 May;53(5):263-5
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  • [Title] Basaloid carcinoma of the lung.
  • Basaloid carcinoma (BC) of the lung is a rare and an aggressive subtype of non small cell lung cancer.
  • We report a patient with preoperative cytologic features of either lung BC or squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Transitional Cell / surgery. Lung Neoplasms / surgery

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  • (PMID = 15952319.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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69. Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA: Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ. Breast J; 2009 Jul-Aug;15(4):409-13
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  • [Title] Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
  • Basaloid carcinomas have been documented in various anatomic locations.
  • We describe a primary invasive adenocarcinoma of the nipple with extensive basaloid features that was also associated with squamous cell carcinoma (SCC) in situ and an aggressive behavior.
  • An excisional specimen showed a 1.7 cm nodule composed of invasive sheets and ribbons of basaloid cells with numerous mitoses, extensive tumor necrosis and evidence of glandular differentiation.
  • The differential diagnosis included a primary basaloid adenocarcinoma of the nipple, basal cell carcinoma of the nipple, neuroendocrine carcinoma, melanoma, basaloid variant of adenoid cystic carcinoma and metastatic disease.
  • Immunohistochemical profile of this tumor supported a primary basaloid adenocarcinoma of the nipple.
  • Although the initial sentinel lymph node biopsy was negative, within a year of diagnosis, the patient developed ipsilateral axillary node and pulmonary metastases.
  • To the best of our knowledge, this is the first case of basaloid carcinoma to be documented in this anatomic site.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Nipples / pathology

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  • (PMID = 19601946.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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70. Ghigna MR, Drak Alsibai K, Porras J, Palazzo L, Godchaux JM, Fabre M: Deep-seated rectal/anal basaloid carcinoma: useful immunocytochemistry in rare squamous cell carcinoma variants. Cytopathology; 2009 Oct;20(5):315-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep-seated rectal/anal basaloid carcinoma: useful immunocytochemistry in rare squamous cell carcinoma variants.
  • OBJECTIVES: To report the cytological aspects of ano-rectal basaloid carcinoma (BC) variant in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) conventional and liquid-based cytology (LBC), in a series of 10 cases of deep-seated squamous cell carcinomas (SCC), and to discuss the diagnostic difficulties in interpreting the morphology and immunocytochemical findings.
  • Of these two cases, only one was correctly diagnosed by EUS-FNA specimen, whereas in the second case, the initial cytological diagnosis was poorly differentiated adenocarcinoma and the final diagnosis of basaloid carcinoma variant was established on surgical resection.
  • Immunocytochemistry (ICC) using CK7, CK20 and CK34betae12 on FNA specimens confirmed the diagnosis retrospectively.
  • CONCLUSION: The diagnosis of basaloid variant of SCC in a rectal location can be very difficult, both on account of the uncommon location and because of the low specificity of morphological aspects on EUS-FNA smears.
  • [MeSH-major] Anus Neoplasms. Carcinoma, Squamous Cell. Immunohistochemistry / methods. Neoplasms, Basal Cell. Rectal Neoplasms

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  • (PMID = 18540877.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Marucci G, Betts CM, Liguori L, Eusebi V: Basaloid carcinoma of the pancreas. Virchows Arch; 2005 Mar;446(3):322-4
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  • [Title] Basaloid carcinoma of the pancreas.
  • A case of basaloid carcinoma of the pancreas in a 26-year-old woman is reported.
  • Small foci of clear-cut squamous differentiation were present.
  • Tumour cells were positive for cytokeratin 14 and P63 and negative for neuroendocrine and acinic cell markers.
  • Basaloid carcinomas may arise in several sites of the body, the most frequent being the anus and oesophagus, and have poor clinical outcome.
  • The present case appears to be, to the best of our knowledge, the first documented example in the literature of basaloid carcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / secondary. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology

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  • [Cites] Histopathology. 2000 Apr;36(4):331-40 [10759947.001]
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  • (PMID = 15726404.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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72. Stewart CJ: Tubulo-squamous vaginal polyp with basaloid epithelial differentiation. Int J Gynecol Pathol; 2009 Nov;28(6):563-6
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  • [Title] Tubulo-squamous vaginal polyp with basaloid epithelial differentiation.
  • Tubulo-squamous polyp is a recently described and apparently benign lesion that most frequently involves the upper vagina of postmenopausal patients.
  • Histologically, it is characterized by the presence of cysts, squamous epithelial nests, and small tubular structures that are surrounded by a hypocellular fibrous stroma.
  • In this report, an additional case of tubulo-squamous polyp is presented in which there was prominent basaloid epithelial differentiation, mainly in the form of elongated cords of cells around the peripheral and deep aspect of the lesion.
  • This feature has not been recorded previously in tubulo-squamous polyp and potentially could create diagnostic difficulty with other lesions such as basal cell/adenoid basal carcinoma or small-cell neuroendocrine carcinoma.
  • [MeSH-minor] Aged. Cell Differentiation. Female. Humans. Immunohistochemistry

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  • (PMID = 19851205.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Khaldi L, Apostolidis TCh, Pappa DA, Apostolidis MT, Apostolidis TI: Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall. Ann Diagn Pathol; 2006 Oct;10(5):297-300

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall.
  • Basaloid squamous carcinoma is a rare variant of squamous cell carcinoma.
  • Histologically, it is identical to basaloid carcinoma at other anatomical sites.
  • Biopsy of the lesion was performed twice, and conventional squamous cell carcinoma was diagnosed; the patient returned 2 months later with progressed metastatic disease.
  • Basaloid squamous carcinoma is a totipotential neoplasm with a grave prognosis.
  • It can be misdiagnosed; therefore, the authors would like to emphasize the significance of this condition in comparison to conventional squamous cell carcinoma, and we provide a review of the relevant recent literature.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Disease Progression. Humans. Immunohistochemistry. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 16979524.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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74. Chetty R, Serra S, Hsieh E: Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant. Am J Surg Pathol; 2005 Dec;29(12):1668-72
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  • [Title] Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant.
  • Two cases of a distinctive variety of basaloid squamous carcinoma (BSC) of the anal canal are described.
  • Histologic evaluation of the tumors showed lobules and aggregates of medium-sized basaloid cells with distinctive peripheral palisading and focal areas of central, comedo-necrosis.
  • Accompanying dysplasia of the overlying squamous mucosa was absent.
  • This appearance together with microcystic spaces simulated that of an adenoid cystic carcinoma.
  • The histologic differential diagnosis is true salivary gland-type adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Immunohistochemistry and awareness of this unusual pattern of BSC will facilitate the correct diagnosis being reached.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Basosquamous / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Antigens, CD20 / metabolism. Antimetabolites, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cisplatin / therapeutic use. DNA-Binding Proteins. Female. Fluorouracil / therapeutic use. Follow-Up Studies. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Keratins / metabolism. Middle Aged. Mitomycin / therapeutic use. Phosphoproteins / metabolism. Radiotherapy. Time Factors. Trans-Activators / metabolism. Transcription Factors. Treatment Outcome. Tumor Burden. Tumor Suppressor Proteins

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  • (PMID = 16327441.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, CD20; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 50SG953SK6 / Mitomycin; 68238-35-7 / Keratins; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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75. Maeda D, Fujii A, Yamaguchi K, Tominaga T, Fukayama M, Mori M: Sarcomatoid carcinoma with a predominant basaloid squamous carcinoma component: the first report of an unusual biphasic tumor of the ureter. Jpn J Clin Oncol; 2007 Nov;37(11):878-83
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  • [Title] Sarcomatoid carcinoma with a predominant basaloid squamous carcinoma component: the first report of an unusual biphasic tumor of the ureter.
  • Malignant tumors of the ureter that display biphasic patterns are very rare; they include carcinosarcomas, sarcomatoid carcinomas and carcinomas with pseudosarcomatous stroma.
  • Although the distinction between carcinosarcomas and sarcomatoid carcinomas has been extensively discussed in the past, the recent World Health Organization classification of urinary tract tumors (2004) does not distinguish the two lesions and use the term sarcomatoid carcinoma to represent these biphasic tumors.
  • The epithelial components of previously reported ureteral biphasic tumors comprise transitional cell carcinoma, squamous cell carcinoma, carcinoma in situ, small cell carcinoma and adenocarcinoma.
  • In this paper, we report the first case of sarcomatoid carcinoma of the ureter with a predominant basaloid squamous carcinoma component.
  • The malignant epithelial component was predominantly composed of basaloid squamous carcinoma, and the sarcomatous component was mostly composed of undifferentiated spindle cells.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Mixed Tumor, Malignant / pathology. Sarcoma / pathology. Ureteral Neoplasms / pathology

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  • (PMID = 18057014.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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76. Kimura T, Mukai M, Shiotani A, Moro K, Ikeda A, Okada Y: Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass. Arch Pathol Lab Med; 2005 Apr;129(4):e94-6
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  • [Title] Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass.
  • We report a case of basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component in an 82-year-old man.
  • Histologically, most (70%) of the tumor was composed of malignant spindle cell proliferation, and the rest (30%) was basaloid squamous carcinoma.
  • The preoperative histologic diagnosis was difficult because the endoscopic biopsy specimens showed only spindle cell proliferation.
  • This is an unusual presentation of basaloid squamous carcinoma of the head and neck.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology

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  • (PMID = 15794698.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Drîgnei-Veselu D, Simionescu C, Georgescu CV, Bogdan F: Histopathological and immunohistochemical aspects in both basaloid and spindle cell variant of cervical carcinoma. Rom J Morphol Embryol; 2006;47(1):43-6
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  • [Title] Histopathological and immunohistochemical aspects in both basaloid and spindle cell variant of cervical carcinoma.
  • The study was performed by using a number of eight cases of cervical carcinomas suiting to basaloid carcinomas and spindle cell carcinomas under the circumstances of usual histopathological staining.
  • Immunohistochemically we used anticytokeratin monoclonal antibody (AE1/AE3) to confirm the epithelial differentiation and also PCNA to evaluate the cell proliferation rate.
  • Immunoexpression for PCNA indicated a high index of cell proliferation for all the cases with a more increased value for the basaloid carcinomas.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Antibodies, Monoclonal. Female. Humans. Immunohistochemistry. Keratins / immunology. Middle Aged. Proliferating Cell Nuclear Antigen / immunology

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  • (PMID = 16838056.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Proliferating Cell Nuclear Antigen; 68238-35-7 / Keratins
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78. Cubilla AL, Lloveras B, Alejo M, Clavero O, Chaux A, Kasamatsu E, Velazquez EF, Lezcano C, Monfulleda N, Tous S, Alemany L, Klaustermeier J, Muñoz N, Quint W, de Sanjose S, Bosch FX: The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay. Am J Surg Pathol; 2010 Jan;34(1):104-14
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  • [Title] The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay.
  • Human papillomavirus (HPV) has been reported in 12-82% of penile squamous cell carcinomas (SCC).
  • There is an association of the virus with basaloid and warty carcinomas but the reported prevalence is variable.
  • The aims of the study were to determine the prevalence of HPV in penile SCC and subtypes using a sensitive technique, to investigate genotypes involved, and to search for other morphologic features associated with the virus from a series of cases from Paraguay.
  • HPV was preferentially associated with warty-basaloid (82%), basaloid (76%), and warty (39%) carcinomas and not detected in verrucous, mixed verrucous-papillary, pseudohyperplastic, and pseudoglandular SCCs.
  • Basaloid cells were more frequently found in HPV positive tumors (72%) and this association was statistically significant in univariate and multivariate analyses.
  • Cells with koilocytotic features and keratinizing squamous cells were also present but to a much lesser degree (47% and 19%, respectively).
  • There was an association between HPV presence and higher histologic grade and with basaloid, warty-basaloid, and warty carcinomas.
  • Our results also suggest that, in penile SCC, the basaloid cell is the best tissue marker for oncogenic HPV infection.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Papillomavirus Infections / pathology. Papillomavirus Infections / virology. Penile Neoplasms / pathology. Penile Neoplasms / virology

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  • (PMID = 20035150.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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79. Chaux A, Tamboli P, Ayala A, Soares F, Rodríguez I, Barreto J, Cubilla AL: Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases. Mod Pathol; 2010 Jun;23(6):896-904
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  • [Title] Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases.
  • Most penile cancers are squamous cell carcinomas, but there are several subtypes with different clinicopathologic, viral, and outcome features.
  • We are presenting 45 cases of a distinctive morphological variant of penile squamous cell carcinoma composed of mixed features of warty and basaloid carcinomas.
  • (1) the most common, observed in two-thirds of the cases was that of a typical condylomatous tumor on surface and basaloid features in deep infiltrative nests;.
  • (2) in 15% of the cases, there were non-papillomatous invasive carcinoma nests with mixed basaloid and warty features; and (3) unusually, predominantly papillomatous.
  • Associated penile intraepithelial neoplasia was identified in 19 cases and mostly showed basaloid, warty-basaloid, or warty features.
  • Warty-basaloid carcinomas are morphologically distinctive human papillomavirus-related penile neoplasms that, such as basaloid carcinomas, are biologically more aggressive than typical warty carcinoma from which they should be distinguished.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Condylomata Acuminata / pathology. Penile Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Brazil. Cell Differentiation. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Papillomaviridae / pathogenicity. Paraguay. Prognosis. Retrospective Studies. Texas. Time Factors

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  • (PMID = 20305615.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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80. Marci V, Volante M, Cappia S, Righi L, Novello C, Scagliotti GV, Brambilla E, Papotti M: Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma. Virchows Arch; 2007 Sep;451(3):729-36
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  • [Title] Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma.
  • The 2004 WHO classification of lung tumours recognised basaloid carcinoma as a variant of squamous and large cell carcinoma.
  • We report a unique case of primary pulmonary adenocarcinoma with a basaloid component.
  • The patient is disease-free 13 months after diagnosis.
  • Histologically, an invasive carcinoma having a glandular and a solid component was observed.
  • The former was an adenocarcinoma with mucus containing spaces lined by columnar mucinous cells and basaloid cells.
  • The solid component was an organoid proliferation of basaloid-type cells, as in cutaneous basal cell carcinoma.
  • Basaloid cells, but not mucinous cells, were immunoreactive for high molecular weight cytokeratins (CK), CK 7 and, focally, for TTF-1.
  • (1) The solid areas resemble a conventional basaloid carcinoma, except for the presence of small mucin-containing spaces. (2) The mucinous adenocarcinoma areas contain two layers of columnar and basaloid cells. (3) Both components are neoplastic based on cell morphology, invasive properties and phenotypic profile.
  • These findings indicate that a basaloid variant of adenocarcinoma is also existing in the spectrum of basaloid carcinomas of the lung.
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell. Humans. Keratins / analysis. Male. Mucins / analysis. Neoplasm Invasiveness. Phenotype. World Health Organization

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  • [Cites] J Natl Cancer Inst. 2005 May 4;97(9):643-55 [15870435.001]
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  • (PMID = 17618455.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Mucins; 68238-35-7 / Keratins
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81. Gurfinkel R, Walfisch S: Combined treatment of basaloid anal carcinoma using cisplatin, 5-fluorouracil and resection of hepatic metastasis. Tech Coloproctol; 2005 Dec;9(3):235-6
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  • [Title] Combined treatment of basaloid anal carcinoma using cisplatin, 5-fluorouracil and resection of hepatic metastasis.
  • The combination of chemotherapy and radiotherapy with subsequent repeated local biopsy has become the standard treatment of epidermoid carcinoma.
  • The optimal treatment of metastatic anal carcinomas is controversial.
  • We present the case of 54-year-old woman with a diagnosis of metastatic basaloid anal carcinoma.
  • The patient underwent resection of liver metastasis in combination with cisplatin + 5FU and local radiotherapy, without evident disease 3 years after diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / secondary. Hepatectomy / methods. Liver Neoplasms / secondary. Liver Neoplasms / therapy

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  • (PMID = 16328122.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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82. Ordi J, Alejo M, Fusté V, Lloveras B, Del Pino M, Alonso I, Torné A: HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. Am J Surg Pathol; 2009 Nov;33(11):1659-65
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  • [Title] HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN.
  • Histologically, classic VIN may be basaloid and characterized by a replacement of the whole epidermis by a homogeneous population of small, "undifferentiated" keratinocytes, which are diffusely positive for p16(INK4a) and negative for p53.
  • Simplex VIN is frequently associated with squamous cell hyperplasia and lichen sclerosus.
  • From a series of 110 invasive squamous cell carcinomas of the vulva negative for HPV by highly sensitive polymerase chain reaction, 51 had VIN lesions located at least 1 cm away from the tumor.
  • In 4 (7.8%) cases, the VIN had basaloid histologic features.
  • All cases showed obvious architectural disorganization with a homogeneous population of basaloid, undifferentiated keratinocytes with scanty cytoplasm replacing the whole epidermis.
  • Squamous cell hyperplasia was identified in 1 case and lichen sclerosus in 1 case.
  • The invasive squamous cell carcinoma was of keratinizing type in 3 cases and basaloid in 1 case.
  • In conclusion, simplex, HPV-negative VIN may occasionally have basaloid morphology.
  • Immunostaining for p16(INK4a) and p53 protein may be helpful in the identification of these lesions and the differential diagnosis with classic, HPV-positive basaloid VIN.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. DNA, Viral / analysis. Diagnosis, Differential. Female. Humans. Hyperplasia. Lichen Sclerosus et Atrophicus / complications. Lichen Sclerosus et Atrophicus / pathology. Middle Aged. Papillomavirus Infections / diagnosis. Skin / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19730361.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Tumor Suppressor Protein p53
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83. Kacerovska D, Szepe P, Vanecek T, Nemcova J, Michal M, Mukensnabl P, Kazakov DV: Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations. Am J Dermatopathol; 2008 Oct;30(5):472-6
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  • [Title] Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations.
  • The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman.
  • Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes.
  • The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Human papillomavirus 16 / pathogenicity. Rectal Neoplasms / pathology. Skin Neoplasms / pathology. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Mutation / genetics

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  • (PMID = 18806492.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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84. Sakakura N, Tateyama H, Usami N, Yokoi K: Thymic basaloid carcinoma with pleural dissemination that developed after a curative resection: report of a case. Surg Today; 2010 Nov;40(11):1073-8
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  • [Title] Thymic basaloid carcinoma with pleural dissemination that developed after a curative resection: report of a case.
  • Thymic basaloid carcinoma is an extremely rare tumor type, with only 10 such reports published to date in the English literature.
  • We herein present a new case of thymic basaloid carcinoma with pleural dissemination that developed after a curative resection.
  • The present case and the review of previous cases indicated that this rare tumor, which had previously been considered to be a low-grade malignant thymic carcinoma, may therefore have a more obstinate and aggressive malignant nature.
  • Histopathologically, a few CD5-positive tumor cells were observed in isolation in the squamous epithelium of the inner cyst wall, thus suggesting that malignant transformation subsequently occurs in a preexisting cyst.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Pleural Neoplasms / secondary. Thymus Neoplasms / pathology

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  • (PMID = 21046508.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Proto-Oncogene Proteins c-bcl-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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85. Moro-Sibilot D, Lantuejoul S, Diab S, Moulai N, Aubert A, Timsit JF, Brambilla C, Brichon PY, Brambilla E: Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis. Eur Respir J; 2008 Apr;31(4):854-9
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  • [Title] Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis.
  • Lung carcinoma with a basaloid pattern (BC) is classified as either a basaloid variant of squamous cell carcinoma (SCC) or as variant of large cell carcinoma (LCC) depending on the presence of a squamous component.
  • In order to confirm its clinical significance in a larger series, 90 BC, including 46 basaloid variants of LCC and 44 basaloid variants of SCC, were compared with 1,328 other nonsmall cell lung carcinoma (NSCLC) with regard to clinical features and survival.
  • The survival of basaloid variants of LCC and SCC was comparable.
  • Basaloid pattern confers a poor prognosis in nonsmall cell lung carcinoma, especially in stage I-II patients, suggesting that lung carcinoma with a basaloid pattern is not only a variant of squamous cell carcinoma or large cell carcinoma, but is a unique entity with a significantly poor prognosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Neoplasms, Squamous Cell / pathology

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  • (PMID = 18094005.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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86. Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL: Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature. Am J Surg Pathol; 2010 Mar;34(3):385-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
  • From the pathogenic point of view, penile cancers may be grouped in human papillomavirus-related and unrelated tumors, each one of them with distinctive morphologic features.
  • The former are predominantly composed of small, undifferentiated basaloid cells, with more or less prominent koilocytic changes, and the latter of keratinizing differentiated squamous cells.
  • On the basis of these observations, we constructed a novel nomenclature for penile precancerous lesions and classified them as penile intraepithelial neoplasia (PeIN) of differentiated, warty, basaloid, and warty-basaloid types.
  • Distribution of PeIN types was: differentiated, 72%; basaloid, 9%; warty-basaloid, 7%; warty, 4%; and mixed, 7%.
  • There was a striking similarity in the morphology of in situ and invasive squamous cell carcinomas.
  • Differentiated PeIN was commonly associated with usual, verrucous, papillary, and other low-grade keratinizing variants of squamous cell carcinoma whereas in basaloid and warty carcinomas the presence of in situ lesions with similar morphology was habitual.
  • To properly distinguish differentiated PeIN from in situ lesions with warty and/or basaloid features only pattern 3, which requires full-thickness staining in all epithelial cells, was considered positive.
  • Using this approach, there was a significant association of the negative patterns and differentiated PeIN and of the positive pattern and warty, basaloid, and warty-basaloid PeIN (P<0.0001).
  • Basaloid variant had the strongest association.
  • Although more studies are necessary to confirm these observations, p16 overexpression seems to be a useful tool for discriminating differentiated from warty, basaloid, and warty-basaloid PeIN.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma in Situ / classification. Carcinoma, Squamous Cell / classification. Condylomata Acuminata / classification. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Papillomavirus Infections / classification. Penile Neoplasms / classification. Precancerous Conditions / classification. Terminology as Topic
  • [MeSH-minor] Cell Differentiation. Diagnosis, Differential. Humans. Immunohistochemistry. Lichen Sclerosus et Atrophicus / classification. Lichen Sclerosus et Atrophicus / metabolism. Male. Neoplasm Invasiveness. Predictive Value of Tests. Sensitivity and Specificity. Up-Regulation

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  • (PMID = 20139761.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
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87. Hatta N, Hirano T, Kimura T, Hashimoto K, Mehregan DR, Ansai S, Takehara K, Takata M: Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels. J Cutan Pathol; 2005 Feb;32(2):131-6
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  • [Title] Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels.
  • BACKGROUND: Distinguishing basal cell carcinoma (BCC) from other benign and malignant skin tumors is sometimes a difficult task for the pathologists.
  • Because the activation of hedgehog signals and the up-regulation of its critical transcriptional factor Gli1 are well documented in BCC, a molecular technique measuring Gli1 transcripts may aide the diagnosis.
  • The tumors included BCC (21), squamous cell carcinoma (13), seborrheic keratoses (8), trichoepithelioma (5), eccrine poroma/porocarcinoma (4), and sebaceous epithelioma/carcinoma (2).
  • The diagnosis was discordant among three pathologists in the remaining 15 tumors.
  • Histological diagnoses included BCC, BCC with sebaceous differentiation, sebaceoma/sebaceous epithelioma, trichoblastoma, trichoepithelioma, basaloid follicular harmartoma, basosquamous carcinoma, etc.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Oncogene Proteins / metabolism. Skin Neoplasms / diagnosis. Transcription Factors / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Trans-Activators. Transcription, Genetic

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  • (PMID = 15606671.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gli protein; 0 / Oncogene Proteins; 0 / RNA, Messenger; 0 / Trans-Activators; 0 / Transcription Factors
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88. Scurry J, Wilkinson EJ: Review of terminology of precursors of vulvar squamous cell carcinoma. J Low Genit Tract Dis; 2006 Jul;10(3):161-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Review of terminology of precursors of vulvar squamous cell carcinoma.
  • The popular term for vulvar squamous cell carcinoma in situ/dysplasia is vulvar intraepithelial neoplasia (VIN).
  • VIN is a histological diagnosis based on loss of squamous epithelial maturation associated with enlarged, hyperchromatic, pleomorphic nuclei and increased, usually atypical mitoses.
  • There are two types of VIN: the usual (not otherwise specified) type, also known as warty-basaloid, and the differentiated type.
  • There are 3 grading systems for warty-basaloid VIN: the traditional 3-grade system of VIN 1-3, a low-grade/high grade Bethesda-like system and the International Society for the Study of Vulvovaginal Disease's proposal for only 1 grade.
  • The ISSVD system eliminates VIN 1 and combines VIN 2 and 3 on the grounds that VIN 1 has not been shown to be a reproducible diagnosis and VIN 2 and 3 are not reliably separated.
  • Warty basaloid VIN may be sub-typed into warty and basaloid VIN.
  • Warty-basaloid VIN may regress.
  • Differentiated VIN has been typically diagnosed co-incident with squamous cell carcinoma.
  • With increased frequency of performance of biopsy of hyperplastic lesions, differentiated VIN should be diagnosed more commonly before squamous carcinoma occurs.
  • [MeSH-major] Carcinoma in Situ / classification. Carcinoma, Squamous Cell / classification. Precancerous Conditions / classification. Terminology as Topic. Vulvar Neoplasms / classification

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  • [CommentIn] J Low Genit Tract Dis. 2006 Jul;10(3):135-6 [16829750.001]
  • (PMID = 16829756.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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89. Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL: Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol; 2009 Aug;182(2):528-34; discussion 534
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
  • PURPOSE: We evaluated clinicopathological features and outcomes in patients with penile squamous cell carcinoma.
  • RESULTS: The usual type of squamous cell carcinoma was noted in 65% of cases.
  • Higher histological grade, deeper anatomical infiltration, and vascular and perineural invasion were common findings in sarcomatoid, basaloid and adenosquamous carcinoma cases, correlating with a higher rate of nodal metastasis and mortality.
  • These features were unusual in verrucous, papillary and warty carcinoma cases.
  • Recurrence in 22% of cases was common for the sarcomatoid, basaloid and adenosquamous types but was not noted for verrucous carcinoma.
  • Locoregional relapse was more common in cases of usual, mixed, papillary and warty carcinoma, and systemic relapse was typical in sarcomatoid and basaloid carcinoma cases.
  • High grade tumors were more common in penectomy cases and carcinoma exclusive of the foreskin had a better prognosis.
  • The nodal metastasis risk groups were low--verrucous, papillary and warty, intermediate--usual and mixed, and high risk--sarcomatoid, basaloid and adenosquamous.
  • Mortality risk groups were low--mixed, papillary and warty, intermediate--usual and basaloid, and high risk--sarcomatoid.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Penile Neoplasms / diagnosis. Penile Neoplasms / surgery

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  • (PMID = 19524964.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Serrano MF, El-Mofty SK, Gnepp DR, Lewis JS Jr: Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol; 2008 Apr;39(4):591-8
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  • [Title] Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck.
  • High-grade neuroendocrine carcinomas of the head and neck overlap significantly in morphology with both basaloid squamous and solid-type adenoid cystic carcinomas.
  • High-grade neuroendocrine carcinomas have sheets of small cells with scant cytoplasm, granular chromatin, and inconspicuous nucleoli.
  • Basaloid squamous and adenoid cystic carcinomas are aggressive variants of their respective tumor types which both have nests of basaloid tumor cells with round nuclei, little cytoplasm, and inconspicuous nucleoli.
  • We performed high molecular weight cytokeratin (CK) and p63 immunohistochemistry on 19 neuroendocrine carcinomas, 18 basaloid squamous carcinomas, and 11 solid-type adenoid cystic carcinomas.
  • All basaloid squamous and adenoid cystic carcinomas were positive for CK 5/6 and 34betaE12.
  • Only 4 and 5 of the 19 neuroendocrine carcinomas, respectively, were positive for these markers.
  • Staining was focal in the neuroendocrine cases when positive, whereas almost all basaloid squamous and adenoid cystic carcinomas showed strong staining.
  • Almost all tumors of each type were positive for p63, including neuroendocrine carcinomas, but with different staining patterns.
  • Basaloid squamous carcinomas were diffusely positive, neuroendocrine carcinomas were diffusely positive, but with weak staining, and adenoid cystic carcinomas showed a distinct pattern with staining at the periphery of the cell nests only.
  • We conclude that high molecular weight cytokeratin immunostaining is helpful in distinguishing high-grade neuroendocrine carcinomas from similar tumor types.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basosquamous / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Head and Neck Neoplasms / diagnosis. Keratins / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-5 / analysis. Keratin-6 / analysis. Male. Membrane Proteins / analysis. Middle Aged. Molecular Weight


91. Pereira MC, Oliveira DT, Landman G, Kowalski LP: Histologic subtypes of oral squamous cell carcinoma: prognostic relevance. J Can Dent Assoc; 2007 May;73(4):339-44
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  • [Title] Histologic subtypes of oral squamous cell carcinoma: prognostic relevance.
  • Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity.
  • The conventional tumour and several histologic subtypes of SCC present morphologic features and specific behaviour when they occur in the oral mucosa.
  • For example, basaloid SCC is an aggressive tumour and verrucous carcinoma has the lowest invasive and metastatic potential; however, the clinical and biologic course of these oral SCC variants has not been completely established.
  • The purpose of this article is to review the various subtypes of oral SCC, emphasizing problems in their histologic diagnosis and prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basosquamous / pathology. Carcinoma, Verrucous / pathology. Humans. Prognosis


92. Velazquez EF, Cubilla AL: Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007). Anal Quant Cytol Histol; 2007 Aug;29(4):185-98
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  • [Title] Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
  • In developed countries, penile squamous cell carcinoma (SCC) account for < 1% of all malignancies in men.
  • It is more frequent in rural populations of Africa, Asia and Latin America, where it may constitute nearly 10% of all carcinomas.
  • Different subtypes of penile carcinomas have been described.
  • Less frequent variants include basaloid (10%), warty (10%), papillary (15%), verrucous (3%), sarcomatoid (4%) and adenosquamous (1%).
  • The prevalence of human papillomavirus (HPV) in invasive SCC is approximately 42%, with a strong association of HPV and basaloid and warty variants.
  • Probable precursor lesions of penile carcinoma include squamous hyperplasia, low and high grade squamous intraepithelial neoplasia and lichen sclerosus.

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  • (PMID = 17879626.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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93. Osakabe M, Hayashi M, Katayama Y, Emura I, Nemoto K, Umezu H, Saitoh K, Motoyama T: Characteristics of vulvar squamous cell carcinoma in Japanese women. Pathol Int; 2007 Jun;57(6):322-7
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  • [Title] Characteristics of vulvar squamous cell carcinoma in Japanese women.
  • Although the presence of racial differences in vulvar squamous cell carcinomas has been suggested, fully analyzed data concerning such tumors in Japanese women have not been reported.
  • A total of 21 vulvar squamous cell carcinomas of Japanese women who lived in north-east Japan, were studied with respect to histological subtype, HPV, p53 and p16(INK4a).
  • The remaining five tumors of basaloid, warty or verrucous types were positive for HPV.
  • HPV-negative tumors showed a trend of greater accumulation of gene abnormalities, including p53 gene mutation, than HPV-positive ones. p16(INK4a) overexpression was shown to not always be a marker for vulvar squamous cell carcinoma in Japanese women with activated high-risk HPV.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Papillomavirus Infections / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 17539962.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Neoplasm; 0 / DNA, Viral; 0 / Tumor Suppressor Protein p53
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94. Yu L, Galan A, McNiff JM: Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma. J Cutan Pathol; 2009 Oct;36(10):1074-176
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma.
  • BACKGROUND: Superficial skin biopsies of basal cell carcinoma (BCC) represent some of the most common dermatopathology specimens.
  • Superficial shave biopsies containing partial samples of lesions with squamatization present difficulties in distinguishing BCC from squamous cell carcinoma (SCC).
  • METHODS: We collected 12 cases of superficial biopsies of BCC with centrally located cords and strands suggesting squamous differentiation at the Yale Dermatopathology Laboratory over a 3-month period and stained them with BerEP4.
  • RESULTS: We found that all cases (12 out of 12) showed membranous and cytoplasmic staining with BerEP4 in the obvious areas of basaloid differentiation at the periphery of the tumors, while cords and strands of enlarged cells with squamoid features in the center and surface of the biopsy failed to label with BerEP4.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Staining and Labeling

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  • [Copyright] 2009 John Wiley & Sons A/S.
  • (PMID = 19187107.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / human epithelial antigen-125
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95. Renaud-Vilmer C, Cavelier-Balloy B, Verola O, Morel P, Servant JM, Desgrandchamps F, Dubertret L: Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma. J Am Acad Dermatol; 2010 Feb;62(2):284-90
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  • [Title] Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma.
  • BACKGROUND: In contrast to vulvar squamous cell carcinoma (SCC), the etiologic factors and precancerous lesions associated with penile carcinoma remain uncertain.
  • OBJECTIVES: To describe the morphologic features of lesions adjacent to invasive penile SCC and their relationship with the associated carcinoma and to compare these associations with vulvar carcinoma.
  • They were classified as penile intraepithelial neoplasia (PIN), squamous hyperplasia (SH), and lichen sclerosus (LS).
  • SCC subtypes were classified as usual, verrucous, warty (condylomatous), basaloid, and mixed.
  • Undifferentiated PIN was always associated with warty (condylomatous) (4 cases), basaloid (16 cases) or mixed SCC (2 cases), and LS with usual (19 cases) or verrucous SCC (7 cases).
  • LIMITATIONS: This was a retrospective analysis CONCLUSION: This study suggests that, similarly to vulvar carcinoma, penile SCC occurs in association with two types of penile lesions: undifferentiated (or bowenoid) PIN and LS-linked differentiated PIN and/or SH.
  • It appears that the subtype of these carcinomas is related to these adjacent lesions.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Squamous Cell / pathology. Penile Neoplasms / pathology

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  • [Copyright] Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20115951.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Mitsuhashi T, Itoh T, Shimizu Y, Ban S, Ogawa F, Hirose T, Shimizu M: Squamous cell carcinoma of the skin: dual differentiations to rare basosquamous and spindle cell variants. J Cutan Pathol; 2006 Mar;33(3):246-52
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  • [Title] Squamous cell carcinoma of the skin: dual differentiations to rare basosquamous and spindle cell variants.
  • Basosquamous carcinoma (BSC) is defined as a tumor containing the areas of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with a transition zone linking the two.
  • Spindle cell squamous carcinoma (SCSC) may have a variable component of conventional SCC and spindle cells.
  • Microscopically, a non-ulcerated upper part of the tumor consisted of large polygonal squamoid cells with occasional keratinization (SCC), trabecular growth of basaloid cells with peripheral palisading (BCC), and an area in which both the components were intermingled.
  • Immunohistochemically, the tumor cells in the SCSC (both conventional and spindle cell) area co-expressed CAM5.2, and vimentin.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic. Female. Humans. Immunohistochemistry. Neoplasms, Multiple Primary

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  • (PMID = 16466514.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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97. Hantschmann P, Sterzer S, Jeschke U, Friese K: P53 expression in vulvar carcinoma, vulvar intraepithelial neoplasia, squamous cell hyperplasia and lichen sclerosus. Anticancer Res; 2005 May-Jun;25(3A):1739-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] P53 expression in vulvar carcinoma, vulvar intraepithelial neoplasia, squamous cell hyperplasia and lichen sclerosus.
  • BACKGROUND: p53 inactivation due to oncogenic viral proteins or mutations is an important molecular mechanism in carcinogenesis, which has also been demonstrated for vulvar carcinoma.
  • To evaluate p53 changes in vulvar carcinogenesis, we analyzed p53 expression in vulvar carcinoma, vulvar intraepithelial neoplasia (VIN), lichen sclerosus (LS) and squamous cell hyperplasia (SH).
  • PATIENTS AND METHODS: Seventy-three carcinomas, 141 cases of VIN, 55 biopsies of LS with 8 associated to carcinoma, 57 cases of SH with 14 associated to carcinoma and 10 cases without neoplastic changes were stained immunohistologically for p53.
  • Forty % of LS and SH not associated to carcinoma showed immunohistological signs of p53 mutation, while cases associated with carcinoma did so in 90%.
  • Sixty-seven % of the carcinomas showed immunohistological changes of p53 expression.
  • Tumors with low p53 expression were significantly associated with patients younger than 50 years (p<0.01) and basaloid or condylomatous tumor type (p<0.015).
  • CONCLUSION: p53 mutations are present in typical keratinizing carcinomas, precursor lesions and disorders with elevated risk for vulvar cancer.
  • Thus, p53 mutation seems to occur early in vulvar carcinogenesis and may become a useful marker, especially in lesions with increased risk of carcinoma.
  • [MeSH-major] Carcinoma in Situ / metabolism. Hyperplasia / metabolism. Lichen Sclerosus et Atrophicus / metabolism. Tumor Suppressor Protein p53 / metabolism. Vulvar Neoplasms / metabolism


98. Puizina-Ivić N, Sapunar D, Marasović D, Mirić L: An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis. Coll Antropol; 2008 Oct;32 Suppl 2:61-5
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  • [Title] An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis.
  • The Bcl-2 protein has been shown to suppress cell death and protects cell against apoptosis induced by different death-inducing signals.
  • In this study the authors have analyzed imunohistochemically the expression of Bcl-2 protein in the histopathological variants of the most common malignant tumors of the skin--basal cell carcinoma (BCC) and squamous cell tumor (SCC), as well as in the precancerous lesion actinic keratosis (AK) and in benign tumor seborrheic keratosis (SK).
  • In cases of hypertrophic and atrophic variants of AK, Bcl-2 expression was confined to basal cell layer, as well as in one case of hypertrophic variant in suprabasal cells.
  • In three histological variants of SK expresseion of Bcl-2 protein was in areas of basaloid proliferation, while in areas of squamous differentiation was negative.
  • In morpheaform variant reduced amount of Bcl-2 expression indicated that this variant of BCC has increased cell proliferation, and in practice shows tendency for recurrence and difficulties to eradicate.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Keratosis, Actinic / metabolism. Keratosis, Seborrheic / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism


99. Denton KJ, Herbert A, Turnbull LS, Waddell C, Desai MS, Rana DN, Dudding N, Smith JH, British Society of Clinical Cytology: The revised BSCC terminology for abnormal cervical cytology. Cytopathology; 2008 Jun;19(3):137-57
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  • [Title] The revised BSCC terminology for abnormal cervical cytology.
  • The BSCC terminology was originally published in 1986 and although highly successful, requires revision.
  • Through a process of professional consensus and literature review this has been undertaken by the BSCC.

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  • [CommentIn] Cytopathology. 2008 Dec;19(6):398-9 [19040547.001]
  • [CommentIn] Cytopathology. 2008 Dec;19(6):400-1 [19040549.001]
  • [CommentIn] Cytopathology. 2008 Dec;19(6):399-400 [19040548.001]
  • (PMID = 18494998.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] England
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100. Chaux A, Lezcano C, Cubilla AL, Tamboli P, Ro J, Ayala A: Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions. Int J Surg Pathol; 2010 Aug;18(4):268-77
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  • [Title] Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions.
  • There is a worldwide geographical variation in the incidence of penile squamous cell carcinoma (PSCC); some subtypes are HPV-related (warty, basaloid) while others (keratinizing variants) are not.
  • The aims of this study were to compare the distribution of different histological subtypes of PSCC from regions of low (Paraguay, 144 cases) and high (USA, 157 cases) incidence and to identify and compare tumors with and without warty and/or basaloid morphology.
  • The distribution of subtypes in the Paraguayan and the American series was: usual, 49.3 and 46.5%; verrucous, 8.3 and 7.6%; papillary NOS, 7.6 and 5.7%; warty, 6.9 and 8.3%; basaloid, 4.2 and 7.0%; sarcomatoid, 0.7 and 0.6%; adenosquamous, 3.5 and 0.6%; and mixed, 19.4 and 23.6%, respectively.
  • The distribution of mixed PSCC was: warty-basaloid, 50.0 and 59.5%; usual-verrucous, 21.4 and 21.6%; usual-warty, 14.3 and 8.1%; usual-basaloid, 7.1 and 0.0%; usual-papillary, 3.6 and 5.4%; and others, 3.6 and 5.4%, respectively.
  • Geographical variation may be the result of staging variation at clinical presentation or of pathological diagnosis.
  • The tendency for typical SCC to mix with verrucous and papillary carcinomas and of the basaloid to preferentially mix with benign condyloma and condylomatous (warty) carcinomas would support the hypothesis of the existence of an etiologically different dual population of penile tumors.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Papillomavirus Infections / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Verrucous / epidemiology. Carcinoma, Verrucous / pathology. Carcinoma, Verrucous / virology. Condylomata Acuminata / pathology. Condylomata Acuminata / virology. Humans. Incidence. Male. Neoplasm Invasiveness. Papillomaviridae / isolation & purification. Paraguay / epidemiology. Precancerous Conditions. Retrospective Studies. United States / epidemiology

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  • (PMID = 19578046.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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