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6. Ghigna MR, Drak Alsibai K, Porras J, Palazzo L, Godchaux JM, Fabre M: Deep-seated rectal/anal basaloid carcinoma: useful immunocytochemistry in rare squamous cell carcinoma variants. Cytopathology; 2009 Oct;20(5):315-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep-seated rectal/anal basaloid carcinoma: useful immunocytochemistry in rare squamous cell carcinoma variants.
  • OBJECTIVES: To report the cytological aspects of ano-rectal basaloid carcinoma (BC) variant in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) conventional and liquid-based cytology (LBC), in a series of 10 cases of deep-seated squamous cell carcinomas (SCC), and to discuss the diagnostic difficulties in interpreting the morphology and immunocytochemical findings.
  • Of these two cases, only one was correctly diagnosed by EUS-FNA specimen, whereas in the second case, the initial cytological diagnosis was poorly differentiated adenocarcinoma and the final diagnosis of basaloid carcinoma variant was established on surgical resection.
  • Immunocytochemistry (ICC) using CK7, CK20 and CK34betae12 on FNA specimens confirmed the diagnosis retrospectively.
  • CONCLUSION: The diagnosis of basaloid variant of SCC in a rectal location can be very difficult, both on account of the uncommon location and because of the low specificity of morphological aspects on EUS-FNA smears.
  • [MeSH-major] Anus Neoplasms. Carcinoma, Squamous Cell. Immunohistochemistry / methods. Neoplasms, Basal Cell. Rectal Neoplasms

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  • (PMID = 18540877.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA: Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ. Breast J; 2009 Jul-Aug;15(4):409-13
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  • [Title] Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
  • Basaloid carcinomas have been documented in various anatomic locations.
  • We describe a primary invasive adenocarcinoma of the nipple with extensive basaloid features that was also associated with squamous cell carcinoma (SCC) in situ and an aggressive behavior.
  • An excisional specimen showed a 1.7 cm nodule composed of invasive sheets and ribbons of basaloid cells with numerous mitoses, extensive tumor necrosis and evidence of glandular differentiation.
  • The differential diagnosis included a primary basaloid adenocarcinoma of the nipple, basal cell carcinoma of the nipple, neuroendocrine carcinoma, melanoma, basaloid variant of adenoid cystic carcinoma and metastatic disease.
  • Immunohistochemical profile of this tumor supported a primary basaloid adenocarcinoma of the nipple.
  • Although the initial sentinel lymph node biopsy was negative, within a year of diagnosis, the patient developed ipsilateral axillary node and pulmonary metastases.
  • To the best of our knowledge, this is the first case of basaloid carcinoma to be documented in this anatomic site.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Nipples / pathology

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  • (PMID = 19601946.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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8. Yamada T, Chiba W, Hitomi S: [Thymic basaloid carcinoma]. Kyobu Geka; 2006 Dec;59(13):1154-8
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  • [Title] [Thymic basaloid carcinoma].
  • We report a case of thymic basaloid carcinoma combined with multilocular thymic cyst (MTC).
  • The tumor was thymic basaloid carcinoma 3 x 2.5 x 2 cm in size combined with MTC 8.2 cm maximum in diameter.
  • Thymic basaloid carcinoma is rare and only 14 cases including the present case have been reported.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Thymus Neoplasms / surgery
  • [MeSH-minor] Aged. Antineoplastic Agents, Phytogenic / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Chemotherapy, Adjuvant. Diagnosis, Differential. Fatal Outcome. Humans. Male. Radiotherapy, Adjuvant

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  • (PMID = 17163206.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 12
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9. Posligua L, Ylagan L: Fine-needle aspiration cytology of thymic basaloid carcinoma: case studies and review of the literature. Diagn Cytopathol; 2006 May;34(5):358-66
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  • [Title] Fine-needle aspiration cytology of thymic basaloid carcinoma: case studies and review of the literature.
  • We report the features in fine-needle aspiration biopsy (FNAB) of thymic basaloid carcinomas.
  • To the best of our knowledge, this is the first fine-needle aspiration (FNA) report on basaloid carcinoma of the thymus.
  • This is a tumor in which the FNA diagnosis is difficult and the differential diagnosis is broad.
  • We describe the cytologic features encountered in the three cases, and immunohistochemical and ultrastructural findings so as to raise awareness of this entity in the differential diagnosis of thymic neoplasms on FNABs.
  • The diagnoses on all three cases were thymic basaloid carcinoma.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Basosquamous / pathology. Thymus Neoplasms / pathology

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  • (PMID = 16604555.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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10. Marci V, Volante M, Cappia S, Righi L, Novello C, Scagliotti GV, Brambilla E, Papotti M: Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma. Virchows Arch; 2007 Sep;451(3):729-36
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  • [Title] Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma.
  • The 2004 WHO classification of lung tumours recognised basaloid carcinoma as a variant of squamous and large cell carcinoma.
  • We report a unique case of primary pulmonary adenocarcinoma with a basaloid component.
  • The patient is disease-free 13 months after diagnosis.
  • Histologically, an invasive carcinoma having a glandular and a solid component was observed.
  • The former was an adenocarcinoma with mucus containing spaces lined by columnar mucinous cells and basaloid cells.
  • The solid component was an organoid proliferation of basaloid-type cells, as in cutaneous basal cell carcinoma.
  • Basaloid cells, but not mucinous cells, were immunoreactive for high molecular weight cytokeratins (CK), CK 7 and, focally, for TTF-1.
  • (1) The solid areas resemble a conventional basaloid carcinoma, except for the presence of small mucin-containing spaces. (2) The mucinous adenocarcinoma areas contain two layers of columnar and basaloid cells. (3) Both components are neoplastic based on cell morphology, invasive properties and phenotypic profile.
  • These findings indicate that a basaloid variant of adenocarcinoma is also existing in the spectrum of basaloid carcinomas of the lung.
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell. Humans. Keratins / analysis. Male. Mucins / analysis. Neoplasm Invasiveness. Phenotype. World Health Organization

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  • [Cites] J Natl Cancer Inst. 2005 May 4;97(9):643-55 [15870435.001]
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  • (PMID = 17618455.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Mucins; 68238-35-7 / Keratins
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11. Morisaki Y, Takagi K, Sano S, Furuya T, Ishikawa M, Torigoe T, Ishii Y: Basaloid carcinoma of the thymus: report of a case. Surg Today; 2006;36(1):68-70
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  • [Title] Basaloid carcinoma of the thymus: report of a case.
  • We report a case of basaloid carcinoma of the thymus, confirmed by histopathological examination, in a 52-year-old man who underwent complete resection.
  • We reviewed the 13 other cases of basaloid carcinoma of the thymus reported in the literature.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Lung Neoplasms / secondary. Thymus Neoplasms / diagnosis

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  • (PMID = 16378197.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Bhagavathi S, Chang CH: Multicentric basaloid carcinoma of lung clinically mimicking metastatic carcinoma: a case report. Int J Surg Pathol; 2009 Feb;17(1):68-71
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  • [Title] Multicentric basaloid carcinoma of lung clinically mimicking metastatic carcinoma: a case report.
  • Basaloid carcinoma of lung is a highly aggressive form of non-small cell and non-neuroendocrine pulmonary carcinoma.
  • It may exist in pure form or may admixed with other types of non-small cell lung carcinoma.
  • A unique case of a multicentric basaloid carcinoma of lung is reported in this study.
  • The morphology of the lesions was identical and consistent with basaloid carcinoma.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male

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  • (PMID = 18480394.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Brown JG, Familiari U, Papotti M, Rosai J: Thymic basaloid carcinoma: a clinicopathologic study of 12 cases, with a general discussion of basaloid carcinoma and its relationship with adenoid cystic carcinoma. Am J Surg Pathol; 2009 Aug;33(8):1113-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymic basaloid carcinoma: a clinicopathologic study of 12 cases, with a general discussion of basaloid carcinoma and its relationship with adenoid cystic carcinoma.
  • Thymic carcinoma (primary carcinoma of the thymic epithelium; type C thymoma) is a rare malignancy.
  • It usually presents in middle-aged to elderly patients and can exhibit a wide variety of morphologic appearances.
  • Thymic basaloid carcinoma (thymic BC) is a particularly rare subtype, with less than 20 cases published in the English literature, mostly in the form of individual case reports.
  • Ages at the time of initial diagnosis ranged from 34 to 77 years (mean 55 y).
  • Five patients died of their disease at an average of 34 months from the time of diagnosis.
  • In this paper, we review the pertinent literature and discuss the possible relationship of thymic BC with thymic adenoid cystic carcinoma, as well as BCs and adenoid cystic carcinomas at other sites.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Transitional Cell / pathology. Thymus Neoplasms / pathology

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  • (PMID = 19461509.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Kacerovska D, Szepe P, Vanecek T, Nemcova J, Michal M, Mukensnabl P, Kazakov DV: Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations. Am J Dermatopathol; 2008 Oct;30(5):472-6
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  • [Title] Spiradenocylindroma-like basaloid carcinoma of the anus and rectum: case report, including HPV studies and analysis of the CYLD gene mutations.
  • The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman.
  • Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes.
  • The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Human papillomavirus 16 / pathogenicity. Rectal Neoplasms / pathology. Skin Neoplasms / pathology. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Mutation / genetics

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  • (PMID = 18806492.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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15. Khaldi L, Apostolidis TCh, Pappa DA, Apostolidis MT, Apostolidis TI: Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall. Ann Diagn Pathol; 2006 Oct;10(5):297-300

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous carcinoma of the larynx. A potential diagnostic pitfall.
  • Basaloid squamous carcinoma is a rare variant of squamous cell carcinoma.
  • Histologically, it is identical to basaloid carcinoma at other anatomical sites.
  • Biopsy of the lesion was performed twice, and conventional squamous cell carcinoma was diagnosed; the patient returned 2 months later with progressed metastatic disease.
  • Basaloid squamous carcinoma is a totipotential neoplasm with a grave prognosis.
  • It can be misdiagnosed; therefore, the authors would like to emphasize the significance of this condition in comparison to conventional squamous cell carcinoma, and we provide a review of the relevant recent literature.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Disease Progression. Humans. Immunohistochemistry. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 16979524.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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16. Mills O, Thomas LB: Basaloid follicular hamartoma. Arch Pathol Lab Med; 2010 Aug;134(8):1215-9
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  • [Title] Basaloid follicular hamartoma.
  • Basaloid follicular hamartoma is a benign lesion of important consideration because it can be mistaken both clinically and histologically for basal cell carcinoma.
  • The formation of basaloid follicular hamartoma has been linked to a mutation in the patched gene, which is part of the same pathway implicated in nevoid basal cell carcinoma syndrome.
  • While these hamartomas are considered benign lesions, malignant growths have been reported to arise within them, which raises the question, "Is basaloid follicular hamartoma a premalignant lesion?
  • [MeSH-major] Hair Diseases / diagnosis. Hair Follicle / pathology. Hamartoma / diagnosis
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Humans. Mutation. Receptors, Cell Surface / genetics. Skin Neoplasms / diagnosis

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  • (PMID = 20670146.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors
  • [Number-of-references] 23
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17. Subramanian B, Agrawal K, Panda K: Basaloid squamous carcinoma of mandible. J Craniofac Surg; 2009 Jan;20(1):151-3

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  • [Title] Basaloid squamous carcinoma of mandible.
  • Basaloid squamous carcinoma is a rare distinct histologic variant of squamous cell carcinoma of the head and neck region.
  • Basaloid squamous carcinoma is more aggressive and has a poorer prognosis, although histologically, it is associated with squamous cell carcinoma and squamous atypia.
  • The usual site of occurrence for basaloid squamous carcinoma is the base of the tongue, hypopharynx (pyriform sinus), and the supraglottic larynx (Wain et al.
  • We are reporting an unusual case of basaloid squmous carcinoma of the mandible with no secondaries and features of sarcomatoid pattern histologically.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mandibular Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Biopsy, Fine-Needle. Bone Wires. Female. Follow-Up Studies. Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Humans. Neck Dissection. Radiography, Panoramic. Radiotherapy, Adjuvant

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  • (PMID = 19165013.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Serrano MF, El-Mofty SK, Gnepp DR, Lewis JS Jr: Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol; 2008 Apr;39(4):591-8
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  • [Title] Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck.
  • High-grade neuroendocrine carcinomas of the head and neck overlap significantly in morphology with both basaloid squamous and solid-type adenoid cystic carcinomas.
  • High-grade neuroendocrine carcinomas have sheets of small cells with scant cytoplasm, granular chromatin, and inconspicuous nucleoli.
  • Basaloid squamous and adenoid cystic carcinomas are aggressive variants of their respective tumor types which both have nests of basaloid tumor cells with round nuclei, little cytoplasm, and inconspicuous nucleoli.
  • We performed high molecular weight cytokeratin (CK) and p63 immunohistochemistry on 19 neuroendocrine carcinomas, 18 basaloid squamous carcinomas, and 11 solid-type adenoid cystic carcinomas.
  • All basaloid squamous and adenoid cystic carcinomas were positive for CK 5/6 and 34betaE12.
  • Only 4 and 5 of the 19 neuroendocrine carcinomas, respectively, were positive for these markers.
  • Staining was focal in the neuroendocrine cases when positive, whereas almost all basaloid squamous and adenoid cystic carcinomas showed strong staining.
  • Almost all tumors of each type were positive for p63, including neuroendocrine carcinomas, but with different staining patterns.
  • Basaloid squamous carcinomas were diffusely positive, neuroendocrine carcinomas were diffusely positive, but with weak staining, and adenoid cystic carcinomas showed a distinct pattern with staining at the periphery of the cell nests only.
  • We conclude that high molecular weight cytokeratin immunostaining is helpful in distinguishing high-grade neuroendocrine carcinomas from similar tumor types.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basosquamous / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Head and Neck Neoplasms / diagnosis. Keratins / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-5 / analysis. Keratin-6 / analysis. Male. Membrane Proteins / analysis. Middle Aged. Molecular Weight


19. Okumura H, Natsugoe S, Yokomakura N, Mataki Y, Haraguchi Y, Sakita H, Mihara Y, Matsumoto M, Imamura S, Kuratsu J, Ishigami S, Takao S, Aikou T: A case of leptomeningeal carcinomatosis from esophageal basaloid carcinoma diagnosed by quantitative reverse transcription-polymerase chain reaction for carcinoembryonic antigen. J Gastroenterol; 2005 Jan;40(1):87-93
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  • [Title] A case of leptomeningeal carcinomatosis from esophageal basaloid carcinoma diagnosed by quantitative reverse transcription-polymerase chain reaction for carcinoembryonic antigen.
  • We describe herein the case of a 68-year-old man who experienced leptomeningitis after esophagectomy from an esophageal basaloid carcinoma.
  • [MeSH-major] Carcinoembryonic Antigen / metabolism. Carcinoma / metabolism. Carcinoma / secondary. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / metabolism. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / metabolism. Meningeal Neoplasms / metabolism. Meningeal Neoplasms / secondary. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15692794.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / RNA, Messenger
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20. Valeri RM, Kaplanis K, Apostolou T, Kiziridou A, Pantidou A, Boussoulegas A, Destouni Ch: Basaloid squamous cell carcinoma of the uterine cervix with an uncommon metastasis to the left iliac region--case report. Eur J Gynaecol Oncol; 2006;27(6):625-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the uterine cervix with an uncommon metastasis to the left iliac region--case report.
  • We describe a rare and interesting case of a basaloid squamous cell carcinoma (BSC) of the uterine cervix with metastasis in the left iliac region diagnosed by fine needle aspiration (FNA).
  • The material was processed by conventional liquid based cytology (ThinPrep), and by the cell-block technique and diagnosis was based on the cytomorphologic and immunochemical characteristics as well as the patient's history.
  • The cytologic diagnosis concerned a poorly differentiated squamous cell carcinoma.
  • The histological diagnosis then was an "infiltrative squamous cell carcinoma of basaloid type" of the uterine cervix.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Pelvic Neoplasms / secondary. Uterine Cervical Neoplasms / pathology

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  • (PMID = 17290600.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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21. Lee PL, Lourduraj LT, Palko MJ 3rd, Jukic DM, English JC 3rd: Hereditary basaloid follicular hamartoma syndrome. Cutis; 2006 Jul;78(1):42-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hereditary basaloid follicular hamartoma syndrome.
  • Basaloid follicular hamartoma syndrome (BFHS) is a rare adnexal tumor genodermatosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Hamartoma / diagnosis. Hand Dermatoses / diagnosis. Skin Diseases / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Syndrome

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  • [CommentIn] Cutis. 2007 Feb;79(2):154; author reply 155-6 [17388219.001]
  • (PMID = 16903320.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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22. Hagemann IS, Lu J, Lewis JS Jr: Basaloid squamous cell carcinoma arising in [corrected] the renal pelvis. Int J Surg Pathol; 2008 Apr;16(2):199-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma arising in [corrected] the renal pelvis.
  • Basaloid squamous cell carcinoma is an uncommon and highly aggressive variant that can occur anywhere squamous cancers occur.
  • In this article, we report the first known case of basaloid squamous cell carcinoma arising in the renal pelvis.
  • Given the aggressive nature of this neoplasm, it should not be omitted from the differential diagnosis of neoplasms arising from the urothelium.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Kidney Neoplasms / pathology. Kidney Pelvis / pathology

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  • [ErratumIn] Int J Surg Pathol.2008 Jul;16(3);355
  • (PMID = 18417681.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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23. Rau AR, Kini H, Naik R, Sahu KK: Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma. Indian J Pathol Microbiol; 2005 Jan;48(1):31-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma.
  • Basaloid squamous cell carcinoma (BSCC) is a high grade variant of Squamous Cell Carcinoma with a predilection for the aero-digestive tract.
  • The typical microscopic features of carcinoma with a basaloid pattern in intimate association with a squamous component helps in diagnosis of this tumour.
  • This study discusses the differential diagnosis of BSCC, as recognition of this tumour may have therapeutic implications.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology

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  • (PMID = 16758784.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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24. Tsunoda Y, Tanaka K, Okada K, Ishizu H, Masuko H, Hata T, Kawamura H, Yokota R, Yamagami H, Watarai H, Yokota K, Tanioka T: [Thymic basaloid carcinoma]. Kyobu Geka; 2010 Sep;63(10):857-61
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  • [Title] [Thymic basaloid carcinoma].
  • Radical thymectomy was performed, and histopathologically the tumor was diagnosed as thymic basaloid carcinoma.
  • Thymic basaloid carcinoma is a rare tumor and is often associated with multilocular thymic cyst.
  • Generally, the malignancy of thymic basaloid carcinomas are regarded as low-grade compared with other thymic carcinomas, however, since mortality and recurrence have been reported, careful follow-up is required.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Thymus Neoplasms / surgery

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  • (PMID = 20845693.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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25. Altrabulsi B, Carrizo F, Luna MA: Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases. Ann Diagn Pathol; 2006 Jun;10(3):149-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases.
  • We describe the clinicopathological and immunohistochemical features of three spindle (sarcomatoid) basaloid squamous carcinomas in three men aged 73, 69, and 59 years with a history of tobacco and alcohol abuse.
  • Histologically, they were composed of conventional basaloid squamous carcinomas with extensive malignant spindle cell proliferation, comprising more than 50% of the tumor.
  • One case in addition expressed CD99 and Bcl-2 and was originally diagnosed as monophasic synovial sarcoma; however, a subsequent biopsy disclosed basaloid squamous cell carcinoma with sarcomatoid stroma.
  • The patients were alive 14 (case patient 1), 10 (case patient 2), and 8 (case patient 3) months after diagnosis.
  • In the absence of evidence from immunohistochemical or electron microscopy studies, a polypoid malignant spindle cell tumor of a mucosal surface of the upper aerodigestive tract should be considered a sarcomatoid carcinoma until proven otherwise.
  • The type of epithelial component would determine the subtype of sarcomatoid carcinoma.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology. Hypopharynx / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 16730309.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. Joshi D, Shivkumar VB, Sharma SM, Gangane N: Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report. Acta Cytol; 2009 Jan-Feb;53(1):89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report.
  • BACKGROUND: Basaloid squamous cell carcinoma is a high-grade variant of squamous cell carcinoma that most commonly occurs in the upper aerodigestive tract.
  • The authors describe the cytologic features of a histologically confirmed case of basaloid squamous cell carcinoma arising in the floor of the mouth.
  • Extracellular basement membrane-like material was also noted, which led to the erroneous diagnosis of adenoid cystic carcinoma.
  • Histopathology characteristically revealed the presence of squamoid nests between malignant basaloid cells, and the tumor was finally diagnosed as basaloid squamous cell carcinoma.
  • CONCLUSION: Basaloid squamous cell carcinoma should be considered in the differential diagnosis of tumors arising in oral cavity.
  • Cytologic diagnosis may be difficult, but careful search for a second cell population of squamoid cells in addition to small basaloid cells may aid in rendering the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Middle Aged

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  • (PMID = 19248560.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Hung JJ, Li AF, Liu JS, Lin YS, Hsu WH: Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma. Ann Thorac Surg; 2008 Mar;85(3):1102-4
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  • [Title] Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma.
  • It often presents as a large intraluminal polypoid tumor with early onset of symptoms resulting in prompt diagnosis.
  • We present here the first case of a carcinosarcoma of the esophagus that had a basaloid squamous cell carcinoma component in addition to the osteosarcoma and without a transitional zone.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinosarcoma / pathology. Esophageal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Osteosarcoma / pathology


28. Campos MS, Modolo F, de Oliveira JS, Pinto-Júnior DS, de Sousa SC: Atypical presentation of oral basaloid squamous cell carcinoma. J Contemp Dent Pract; 2009;10(2):98-104
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  • [Title] Atypical presentation of oral basaloid squamous cell carcinoma.
  • AIM: The purpose of this report is to present the clinical and histological features of a basaloid squamous cell carcinoma (BSCC) occurring in the retromolar trigone of a 59-year-old man and to relate its immunohistochemical characteristics.
  • BACKGROUND: BSCC is an aggressive distinct variant of squamous cell carcinoma (SCC) requiring recognition as a separate entity from SCC due to its peculiar behavior.
  • Histologically, nests and cords of closely packed, moderately pleomorphic basaloid cells with nuclear palisading along the periphery of the neoplastic nests surrounded by a fibrous stroma were found.
  • SUMMARY: Since this tumor can mimic other neoplasms such as adenoid cystic carcinoma, neuroendocrine carcinoma, and basal cell adenocarcinoma, histological features are essential to differentiate between them.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Transitional Cell / diagnosis. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Cell Nucleus / ultrastructure. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Keratins / analysis. Ki-67 Antigen / analysis. Laminin / analysis. Male. Middle Aged. Mitosis. Necrosis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 19279978.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Laminin; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
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29. Ozgursoy OB, Yorulmaz I, Tulunay O: Rapid and unusual spread of basaloid squamous cell carcinoma of the maxillary sinus. B-ENT; 2008;4(4):233-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid and unusual spread of basaloid squamous cell carcinoma of the maxillary sinus.
  • Basaloid squamous cell carcinoma is a variant of epidermoid carcinoma with a morphology consisting of both basaloid and squamous cell components.
  • In this report, we present the aggressive course of a basaloid squamous cell carcinoma of the maxillary sinus in a 28-year-old patient who died only four months after the initial diagnosis.
  • [MeSH-major] Carcinoma, Basosquamous / secondary. Maxillary Sinus Neoplasms / pathology

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  • (PMID = 19227029.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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30. Chen JX, Tang Q, Zhu HN, Zheng YD: [Diagnosis and treatment of basaloid squamous cell carcinoma of the esophagus]. Zhonghua Zhong Liu Za Zhi; 2008 May;30(5):392-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of basaloid squamous cell carcinoma of the esophagus].
  • OBJECTIVE: To investigate the histopathological features of basaloid squamous cell carcinoma of the esophagus, and to explore the ways of its diagnosis, differential diagnosis and treatment.
  • METHODS: The clinical data and pathological features of 23 cases of esophageal basaloid squamous cell carcinoma were reviewed and analyzed retrospectively.
  • CONCLUSION: The basaloid squamous cell carcinoma of the esophagus is highly malignant with poor prognosis.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Carcinoma, Basosquamous / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy. Esophagus / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / diagnosis. Cisplatin / administration & dosage. Combined Modality Therapy. Diagnosis, Differential. Esophagectomy / methods. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Middle Aged. Radiotherapy, High-Energy. Retrospective Studies. Survival Rate

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  • (PMID = 18953844.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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31. Nagakawa H, Hiroshima K, Takiguchi Y, Yatomi M, Takahashi Y, Mikami M, Nakatani Y, Kuriyama T: Basaloid squamous-cell carcinoma of the lung in a young woman. Int J Clin Oncol; 2006 Feb;11(1):66-8
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  • [Title] Basaloid squamous-cell carcinoma of the lung in a young woman.
  • We report a rare case of basaloid squamous cell carcinoma of the lung in a young Japanese woman.
  • Transbronchial fine-needle aspiration cytology supported a tentative diagnosis of primary squamous-cell carcinoma of the lung.
  • Necropsy established the diagnosis of basaloid squamous-cell carcinoma of the lung.
  • This is the youngest patient with a case of basaloid squamous cell carcinoma of the lung ever reported.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 16508733.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Karatzanis AD, Fragkiadakis GM, Prokopakis EP, Koutsopoulos AV, Helidonis ES, Velegrakis GA: Basaloid squamous cell carcinoma of the soft palate: case report. Auris Nasus Larynx; 2008 Dec;35(4):592-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the soft palate: case report.
  • Basaloid squamous cell carcinoma (BSCC) is a histologically distinct variant of squamous cell carcinoma.
  • In this report, we present a case of basaloid squamous cell carcinoma of the soft palate.
  • The therapeutic strategy and histological findings are described in detail, including immunohistochemistry with the use of involucrin, an agent used for the first time for BSCC diagnosis.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Carcinoma, Squamous Cell / diagnosis. Palatal Neoplasms / diagnosis. Palate, Soft
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biopsy. Coloring Agents. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Protein Precursors. Radiotherapy, Adjuvant. Reoperation. Tomography, X-Ray Computed

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  • (PMID = 18242906.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Protein Precursors; 60108-77-2 / involucrin
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33. Gurfinkel R, Walfisch S: Combined treatment of basaloid anal carcinoma using cisplatin, 5-fluorouracil and resection of hepatic metastasis. Tech Coloproctol; 2005 Dec;9(3):235-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined treatment of basaloid anal carcinoma using cisplatin, 5-fluorouracil and resection of hepatic metastasis.
  • The combination of chemotherapy and radiotherapy with subsequent repeated local biopsy has become the standard treatment of epidermoid carcinoma.
  • The optimal treatment of metastatic anal carcinomas is controversial.
  • We present the case of 54-year-old woman with a diagnosis of metastatic basaloid anal carcinoma.
  • The patient underwent resection of liver metastasis in combination with cisplatin + 5FU and local radiotherapy, without evident disease 3 years after diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / secondary. Hepatectomy / methods. Liver Neoplasms / secondary. Liver Neoplasms / therapy

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  • (PMID = 16328122.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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34. Soriano E, Righini Ch, Faure C, Lantuejoul S, Colonna M, Bolla M, Brambilla E, Reyt E: [Course and prognosis of basaloid squamous cell carcinoma: case-control study of 49 patients]. Ann Otolaryngol Chir Cervicofac; 2005 Sep;122(4):173-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Course and prognosis of basaloid squamous cell carcinoma: case-control study of 49 patients].
  • INTRODUCTION: The course and prognosis of basaloid squamous cell carcinoma (BSCC) are not well known.
  • MATERIALS AND METHODS: We analyzed a retrospective cohort of 49 patients with BSCC in comparison with a cross-matched population of 49 patients treated for well- to moderately differentiated squamous cell carcinoma (SCC).
  • CONCLUSIONS: We consider BSCC patients as a high-risk population and we complete diagnosis explorations including a FDG-PET before curative treatment.
  • [MeSH-major] Carcinoma, Basosquamous. Head and Neck Neoplasms
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Case-Control Studies. Cohort Studies. Female. France / epidemiology. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 16230937.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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35. Ordi J, Alejo M, Fusté V, Lloveras B, Del Pino M, Alonso I, Torné A: HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. Am J Surg Pathol; 2009 Nov;33(11):1659-65
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  • [Title] HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN.
  • Histologically, classic VIN may be basaloid and characterized by a replacement of the whole epidermis by a homogeneous population of small, "undifferentiated" keratinocytes, which are diffusely positive for p16(INK4a) and negative for p53.
  • From a series of 110 invasive squamous cell carcinomas of the vulva negative for HPV by highly sensitive polymerase chain reaction, 51 had VIN lesions located at least 1 cm away from the tumor.
  • In 4 (7.8%) cases, the VIN had basaloid histologic features.
  • All cases showed obvious architectural disorganization with a homogeneous population of basaloid, undifferentiated keratinocytes with scanty cytoplasm replacing the whole epidermis.
  • The invasive squamous cell carcinoma was of keratinizing type in 3 cases and basaloid in 1 case.
  • In conclusion, simplex, HPV-negative VIN may occasionally have basaloid morphology.
  • Immunostaining for p16(INK4a) and p53 protein may be helpful in the identification of these lesions and the differential diagnosis with classic, HPV-positive basaloid VIN.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. DNA, Viral / analysis. Diagnosis, Differential. Female. Humans. Hyperplasia. Lichen Sclerosus et Atrophicus / complications. Lichen Sclerosus et Atrophicus / pathology. Middle Aged. Papillomavirus Infections / diagnosis. Skin / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19730361.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Tumor Suppressor Protein p53
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36. Chetty R, Serra S, Hsieh E: Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant. Am J Surg Pathol; 2005 Dec;29(12):1668-72
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  • [Title] Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant.
  • Two cases of a distinctive variety of basaloid squamous carcinoma (BSC) of the anal canal are described.
  • Histologic evaluation of the tumors showed lobules and aggregates of medium-sized basaloid cells with distinctive peripheral palisading and focal areas of central, comedo-necrosis.
  • This appearance together with microcystic spaces simulated that of an adenoid cystic carcinoma.
  • The histologic differential diagnosis is true salivary gland-type adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Immunohistochemistry and awareness of this unusual pattern of BSC will facilitate the correct diagnosis being reached.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Basosquamous / pathology

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  • (PMID = 16327441.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, CD20; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 50SG953SK6 / Mitomycin; 68238-35-7 / Keratins; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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37. Oztürk O, Sari M, Inanli S, Kara EK: Basaloid squamous cell carcinoma of the larynx: a case report. Kulak Burun Bogaz Ihtis Derg; 2005;15(5-6):125-9
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  • [Title] Basaloid squamous cell carcinoma of the larynx: a case report.
  • Basaloid squamous cell carcinoma (SCC) is a very rare, high grade, and aggressive variant of SCC, with a predilection for the upper aerodigestive system.
  • We present a 50-year-old man with basaloid SCC of the supraglottic larynx, which was initially misdiagnosed as SCC.
  • Basaloid SCC should be considered in the differential diagnosis of upper aerodigestive system malignancies because it has a distinct prognostic significance compared to conventional SCC.
  • [MeSH-major] Carcinoma, Basosquamous / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16444094.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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38. Bekavac-Beslin M, Mijić A, Matejcić A, Ferencić Z: Basaloid squamous cell carcinoma of the esophagus: a case report. Tumori; 2005 Jan-Feb;91(1):87-9
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  • [Title] Basaloid squamous cell carcinoma of the esophagus: a case report.
  • Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / therapy

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  • (PMID = 15850013.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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39. Cakir E, Demirag F, Ucoluk GO, Kaya S, Memis L: Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation. Lung Cancer; 2007 Jul;57(1):109-11
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  • [Title] Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation.
  • Basaloid squamous cell carcinoma of the lung, an uncommon subtype of non-small cell carcinomas was introduced as a distinct entity in the recently revised World Health Organization (WHO) classification of lung tumours.
  • We report a 23-years-old female patient with basaloid squamous cell carcinoma of the lung who was stage IIB post-operatively.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 17328988.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 68238-35-7 / Keratins
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40. Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA: Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis. J Clin Pathol; 2010 Oct;63(10):857-66
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  • [Title] Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
  • Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma (SCC) of the head and neck.
  • Wain's criteria (peripheral palisading, association with SCC, high nuclear-cytoplasmic ratio, high mitotic rate, solid growth), anti-34BE12 and CK 5/6 staining, and absence of neuroendocrine markers are mandatory for the diagnosis of BSCC.
  • On the other hand, BSCC is frequently considered a high-grade carcinoma of poorer prognosis than its SCC counterparts, mostly due to a higher rate of distant metastases.
  • The basaloid subtype of SCC, owing to its particular behaviour, should be systematically investigated along with HPV and smoking status, as those factors may be determinant in the response to treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Head and Neck Neoplasms / virology. Papillomavirus Infections / complications
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Combined Modality Therapy. Diagnosis, Differential. Humans. Prognosis


41. Patel AB, Harting MS, Smith-Zagone MJ, Hsu S: Familial basaloid follicular hamartoma: a report of one family. Dermatol Online J; 2008;14(4):14
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  • [Title] Familial basaloid follicular hamartoma: a report of one family.
  • Basaloid follicular hamartoma is a rare but benign adnexal neoplasm that can simulate basal cell carcinoma.
  • Criteria for distinction between the hamartoma and carcinoma are delineated, although evolution of basaloid follicular hamartoma into basal cell carcinoma may also be a possibility.
  • [MeSH-major] Hamartoma / diagnosis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Receptors, Cell Surface / genetics. Skin / pathology

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  • (PMID = 18627736.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors
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42. Oikawa K, Tabuchi K, Nomura M, Okubo H, Wada T, Iijima T, Hara A: Basaloid squamous cell carcinoma of the maxillary sinus: a report of two cases. Auris Nasus Larynx; 2007 Mar;34(1):119-23
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  • [Title] Basaloid squamous cell carcinoma of the maxillary sinus: a report of two cases.
  • Basaloid squamous cell carcinoma (BSCC) is a highly aggressive neoplasm and a histologically distinctive variant of squamous cell carcinoma.
  • He died of lung metastasis 6 months after the initial diagnosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Maxillary Sinus / pathology. Maxillary Sinus / radiography. Paranasal Sinus Neoplasms / diagnosis

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  • (PMID = 17141998.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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43. Kwon YS, Kim YM, Choi GW, Kim YT, Nam JH: Pure basaloid squamous cell carcinoma of the uterine cervix: a case report. J Korean Med Sci; 2009 Jun;24(3):542-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pure basaloid squamous cell carcinoma of the uterine cervix: a case report.
  • Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare malignancy of the female genital tract with a poorer clinical outcome than squamous cell carcinoma of the uterine cervix.
  • We report a case of pure basaloid squamous cell carcinoma of the uterine cervix.
  • A basaloid squamous cell carcinoma of the uterine cervix, of International Federation of Gynecology and Obstetrics (FIGO) stage Ib1, was diagnosed by a loop electrosurgical excision procedure cone biopsy.
  • Pathologic findings were consistent with a basaloid squamous cell carcinoma confined to the cervix without an extracervical tumor.
  • Although basaloid squamous cell carcinoma of the uterine cervix is thought to behave aggressively, accumulation of data on these rare tumors is necessary to determine whether their behavior differs significantly from that of conventional cervical squamous cell carcinoma of similar clinical stage.
  • These data would be useful for defining the best diagnosis and treatment for these rare tumors.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Uterine Cervical Neoplasms / diagnosis

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  • (PMID = 19543425.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2698210
  • [Keywords] NOTNLM ; Basaloid / Carcinoma, Squamous Cell / Cervix Uteri
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44. Mahmoodi M, Asad H, Salim S, Kantor G, Minimo C: Anti-cytokeratin 20 staining of Merkel cells helps differentiate basaloid proliferations overlying dermatofibromas from basal cell carcinoma. J Cutan Pathol; 2005 Aug;32(7):491-5
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  • [Title] Anti-cytokeratin 20 staining of Merkel cells helps differentiate basaloid proliferations overlying dermatofibromas from basal cell carcinoma.
  • BACKGROUND: Basaloid epidermal proliferations (BEP), morphologically resembling basal cell carcinoma (BCC), have been described overlying dermatofibromas.
  • Anti-CK20 staining of Merkel cells helps differentiate basaloid proliferations overlying dermatofibromas from basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Intermediate Filament Proteins / analysis. Merkel Cells / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cell Count. Cell Proliferation. Diagnosis, Differential. Epidermis / chemistry. Epidermis / pathology. Female. Humans. Immunoenzyme Techniques. Infant, Newborn. Keratin-20. Male. Middle Aged

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  • (PMID = 16008693.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / Keratin-20
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45. Yu GY, Gao Y, Peng X, Chen Y, Zhao FY, Wu MJ: A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region. Int J Oral Maxillofac Surg; 2008 Nov;37(11):1003-8
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  • [Title] A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region.
  • Basaloid squamous cell carcinoma (BSCC) is a rare distinct variant of squamous cell carcinoma (SCC).
  • Twelve BSCC patients were diagnosed with grade II or III conventional SCC when the original records of the primary diagnosis for the 15 patients with BSCC were reviewed.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Mouth Neoplasms / pathology. Neoplasm Recurrence, Local / pathology


46. Marucci G, Betts CM, Liguori L, Eusebi V: Basaloid carcinoma of the pancreas. Virchows Arch; 2005 Mar;446(3):322-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid carcinoma of the pancreas.
  • A case of basaloid carcinoma of the pancreas in a 26-year-old woman is reported.
  • Basaloid carcinomas may arise in several sites of the body, the most frequent being the anus and oesophagus, and have poor clinical outcome.
  • The present case appears to be, to the best of our knowledge, the first documented example in the literature of basaloid carcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / secondary. Pancreatic Neoplasms / metabolism. Pancreatic Neoplasms / pathology

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  • (PMID = 15726404.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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47. Kimura T, Mukai M, Shiotani A, Moro K, Ikeda A, Okada Y: Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass. Arch Pathol Lab Med; 2005 Apr;129(4):e94-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component exhibiting a pedunculated polypoid mass.
  • We report a case of basaloid squamous carcinoma of the hypopharynx with an extensive spindle cell component in an 82-year-old man.
  • Histologically, most (70%) of the tumor was composed of malignant spindle cell proliferation, and the rest (30%) was basaloid squamous carcinoma.
  • The preoperative histologic diagnosis was difficult because the endoscopic biopsy specimens showed only spindle cell proliferation.
  • This is an unusual presentation of basaloid squamous carcinoma of the head and neck.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Hypopharyngeal Neoplasms / pathology

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  • (PMID = 15794698.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Winters R, Naud S, Evans MF, Trotman W, Kasznica P, Elhosseiny A: Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases. Head Neck Pathol; 2008 Dec;2(4):265-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases.
  • Diagnosis of basaloid squamous carcinoma (BSCC) currently relies mainly on histological criteria, with variable immunohistochemical results reported in small series.
  • We explored the use of a battery of immunohistochemical stains to elucidate this diagnosis on 45 cases of BSCC.
  • Forty-five cases of BSCC and 34 site-matched cases of squamous cell carcinoma (SCC) were obtained from the archives of the pathology department at our institution.

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  • (PMID = 20614292.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] ENG
  • [Grant] United States / PHS HHS / / 22435-22
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Viral; 0 / Keratin-1; 0 / Keratin-14; 0 / Keratin-7; 0 / human epithelial antigen-125
  • [Other-IDs] NLM/ PMC2807584
  • [Keywords] NOTNLM ; Basaloid squamous carcinoma / Basosquamous carcinoma / Immunohistochemistry / Squamous cell carcinoma
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49. Salerno G, Di Vizio D, Staibano S, Mottola G, Quaremba G, Mascolo M, Galli V, De Rosa G, Insabato L: Prognostic value of p27Kip1 expression in Basaloid Squamous Cell Carcinoma of the larynx. BMC Cancer; 2006;6:146
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic value of p27Kip1 expression in Basaloid Squamous Cell Carcinoma of the larynx.
  • BACKGROUND: Very few reports have investigated the role of cell cycle regulators as biomarkers in Basaloid Squamous Cell Carcinoma (BSCC) of the larynx, a definite morphologic, uncommon, very aggressive variant of squamous cell carcinoma.
  • [MeSH-major] Biomarkers / analysis. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / metabolism

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  • (PMID = 16740156.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CDKN1B protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ PMC1559634
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50. Friedrich RE, Sperber C, Jäkel T, Röser K, Löning T: Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression. Anticancer Res; 2010 May;30(5):1605-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression.
  • Basaloid squamous cell carcinoma is a variant of squamous cell carcinoma, preferentially arising in the head and neck region.
  • Current reports point to an association of basaloid squamous cell carcinoma (BSCC) and human papilloma virus (HPV) infection.
  • The aim of this study was to analyse the HPV infection status in different entities of oral neoplasms or dysplasias with basaloid differentiation of epithelial cells.
  • This was an essential difference of this collective compared to genital carcinomas with HPV high-risk infections.
  • Type-specific analysis of HPV infection in head and neck cancer may be important in the differential diagnosis of malignancies in the head and neck region with a basaloid growth pattern.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / virology. Epithelial Cells / metabolism. Epithelial Cells / virology. Gene Expression Regulation, Viral. Mouth Neoplasms / metabolism. Mouth Neoplasms / virology. Neoplasm Proteins / metabolism. Papillomavirus Infections / metabolism

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  • (PMID = 20592349.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / P16 protein, human
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56. Chaux A, Soares F, Rodríguez I, Barreto J, Lezcano C, Torres J, Velazquez EF, Cubilla AL: Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases. Am J Surg Pathol; 2010 Feb;34(2):223-30
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  • [Title] Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases.
  • There is a group of low-grade papillomatous squamous cell carcinomas (SCC) of the penis, collectively designated as "verruciform," that are difficult to classify.
  • A proposal of classification grouped these tumors in warty (condylomatous), verrucous, and papillary carcinomas.
  • Papillary carcinomas were large (mean 5.6 cm) exophytic low-grade squamous neoplasms with hyperkeratosis and papillomatosis.
  • In conclusion, papillary carcinomas were exophytic albeit, often deeply invasive low-grade neoplasms, with a low rate of nodal metastasis characterized by complex papillae, irregular fibrovascular cores, and jagged tumor base.
  • Papillary SCC should be distinguished from other penile verruciform tumors, including verrucous and variants, warty and papillary basaloid carcinomas, and carcinoma cuniculatum.
  • Helpful morphologic features for differential diagnosis are provided.
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Verrucous / pathology. Penile Neoplasms / pathology

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  • (PMID = 20061934.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Haykal S, Al Habeeb AS, Goldstein DP, Murray CA, Ghazarian D: Infundibular carcinoma of the skin: a distinct morphological and immunohistochemical entity. J Clin Pathol; 2010 May;63(5):455-62
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  • [Title] Infundibular carcinoma of the skin: a distinct morphological and immunohistochemical entity.
  • This report describes a new entity which has been defined as infundibular carcinoma (IC) of the skin.
  • This new entity must be distinguished from other basaloid carcinomas arising from the epidermis, the hair follicles or from sweat duct and glandular elements.
  • A brief review of benign and malignant tumours of the pilar unit and the differential diagnosis of IC is also provided.
  • [MeSH-major] Carcinoma / pathology. Hair Diseases / pathology. Hair Follicle. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20418236.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 24
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58. Stelow EB, Mills SE: Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol; 2005 Dec;124 Suppl:S96-109
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  • [Title] Squamous cell carcinoma variants of the upper aerodigestive tract.
  • Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract.
  • In such cases, correct diagnosis is important for prognostic and therapeutic reasons.
  • This article discusses the clinicopathologic features of the upper aerodigestive tract variants of SCC, including verrucous carcinoma, papillary squamous cell carcinoma, basaloid squamous cell carcinoma, spindle cell carcinoma, adenosquamous carcinoma, adenoid squamous cell carcinoma, and undifferentiated carcinoma.
  • It also discusses the differential diagnoses that must be considered and the use of ancillary testing, especially immunohistochemical analysis, for determining the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Digestive System Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Papillary / pathology. Humans

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  • (PMID = 16468420.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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59. Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL: Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol; 2009 Aug;182(2):528-34; discussion 534
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
  • PURPOSE: We evaluated clinicopathological features and outcomes in patients with penile squamous cell carcinoma.
  • RESULTS: The usual type of squamous cell carcinoma was noted in 65% of cases.
  • Higher histological grade, deeper anatomical infiltration, and vascular and perineural invasion were common findings in sarcomatoid, basaloid and adenosquamous carcinoma cases, correlating with a higher rate of nodal metastasis and mortality.
  • These features were unusual in verrucous, papillary and warty carcinoma cases.
  • Recurrence in 22% of cases was common for the sarcomatoid, basaloid and adenosquamous types but was not noted for verrucous carcinoma.
  • Locoregional relapse was more common in cases of usual, mixed, papillary and warty carcinoma, and systemic relapse was typical in sarcomatoid and basaloid carcinoma cases.
  • High grade tumors were more common in penectomy cases and carcinoma exclusive of the foreskin had a better prognosis.
  • The nodal metastasis risk groups were low--verrucous, papillary and warty, intermediate--usual and mixed, and high risk--sarcomatoid, basaloid and adenosquamous.
  • Mortality risk groups were low--mixed, papillary and warty, intermediate--usual and basaloid, and high risk--sarcomatoid.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Penile Neoplasms / diagnosis. Penile Neoplasms / surgery

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  • (PMID = 19524964.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Chaux A, Lezcano C, Cubilla AL, Tamboli P, Ro J, Ayala A: Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions. Int J Surg Pathol; 2010 Aug;18(4):268-77
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  • [Title] Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions.
  • There is a worldwide geographical variation in the incidence of penile squamous cell carcinoma (PSCC); some subtypes are HPV-related (warty, basaloid) while others (keratinizing variants) are not.
  • The aims of this study were to compare the distribution of different histological subtypes of PSCC from regions of low (Paraguay, 144 cases) and high (USA, 157 cases) incidence and to identify and compare tumors with and without warty and/or basaloid morphology.
  • The distribution of subtypes in the Paraguayan and the American series was: usual, 49.3 and 46.5%; verrucous, 8.3 and 7.6%; papillary NOS, 7.6 and 5.7%; warty, 6.9 and 8.3%; basaloid, 4.2 and 7.0%; sarcomatoid, 0.7 and 0.6%; adenosquamous, 3.5 and 0.6%; and mixed, 19.4 and 23.6%, respectively.
  • The distribution of mixed PSCC was: warty-basaloid, 50.0 and 59.5%; usual-verrucous, 21.4 and 21.6%; usual-warty, 14.3 and 8.1%; usual-basaloid, 7.1 and 0.0%; usual-papillary, 3.6 and 5.4%; and others, 3.6 and 5.4%, respectively.
  • Geographical variation may be the result of staging variation at clinical presentation or of pathological diagnosis.
  • The tendency for typical SCC to mix with verrucous and papillary carcinomas and of the basaloid to preferentially mix with benign condyloma and condylomatous (warty) carcinomas would support the hypothesis of the existence of an etiologically different dual population of penile tumors.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Papillomavirus Infections / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Verrucous / epidemiology. Carcinoma, Verrucous / pathology. Carcinoma, Verrucous / virology. Condylomata Acuminata / pathology. Condylomata Acuminata / virology. Humans. Incidence. Male. Neoplasm Invasiveness. Papillomaviridae / isolation & purification. Paraguay / epidemiology. Precancerous Conditions. Retrospective Studies. United States / epidemiology

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  • (PMID = 19578046.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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61. Hammar SP: Approach to the diagnosis of neuroendocrine lung neoplasms: variabilities and pitfalls. Semin Thorac Cardiovasc Surg; 2006;18(3):183-90
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  • [Title] Approach to the diagnosis of neuroendocrine lung neoplasms: variabilities and pitfalls.
  • With the publication of the spectrum of neuroendocrine proliferations and neoplasms and the features and criteria for diagnosing neuroendocrine lung neoplasms, there is more agreement in making a specific pathologic diagnosis of a neuroendocrine lung neoplasm.
  • However, problems exist, especially in diagnosing well-differentiated neuroendocrine carcinomas (atypical carcinoids), large-cell neuroendocrine carcinomas, and even some small-cell lung cancers.
  • Nonneuroendocrine small-cell carcinomas exist and include small-cell squamous cell carcinoma, small cell adenocarcinoma, and basaloid carcinoma.
  • Nonneuroendocrine lung cancers, especially large-cell undifferentiated carcinoma and poorly differentiated adenocarcinoma, not infrequently express neuroendocrine markers immunohistochemically.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Humans. Immunohistochemistry

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  • (PMID = 17185177.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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62. Rabban JT, Swain RS, Zaloudek CJ, Chase DR, Chen YY: Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers. Mod Pathol; 2006 Oct;19(10):1351-7
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  • [Title] Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers.
  • Adenoid cystic carcinoma of the breast is a rare neoplasm whose cribriform architecture may mimic invasive cribriform carcinoma, cribriform ductal carcinoma in situ, and collagenous spherulosis.
  • The diagnosis may be even more challenging in needle core biopsies.
  • Immunohistochemical expression of p63 and c-kit distinguishes adenoid cystic carcinoma from invasive cribriform carcinoma and ductal carcinoma in situ.
  • A formal comparison of the immunophenotype of adenoid cystic carcinoma to collagenous spherulosis has not been reported.
  • We evaluated smooth muscle actin, p63, calponin, smooth muscle myosin heavy chain, as well as c-kit, in nine cases of cribriform pattern adenoid cystic carcinoma of the breast in comparison to 12 cases of collagenous spherulosis.
  • Both entities strongly expressed p63 and smooth muscle actin; in adenoid cystic carcinoma, the basaloid myoepithelial-like tumor cells expressed these markers, but the ductular epithelial cells did not.
  • Neither calponin nor smooth muscle myosin heavy chain was expressed in adenoid cystic carcinoma but both were strongly expressed in collagenous spherulosis.
  • Whereas the ductular epithelial cells of adenoid cystic carcinoma were positive for c-kit in all cases, collagenous spherulosis was negative for c-kit.
  • Positive p63 expression by a cribriform breast lesion is not sufficiently specific to confirm a diagnosis of adenoid cystic carcinoma.
  • A broader panel that includes calponin or smooth muscle myosin heavy chain and c-kit is required to exclude collagenous spherulosis in settings in which the distinctive morphologic features that separate these entities are not conspicuously present.
  • [MeSH-major] Biomarkers, Tumor / analysis. Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Collagen. Epithelial Cells / pathology
  • [MeSH-minor] Actins / analysis. Calcium-Binding Proteins / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Membrane Proteins / analysis. Microfilament Proteins / analysis. Myosin Heavy Chains / analysis. Proto-Oncogene Proteins c-kit / analysis. Retrospective Studies

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  • (PMID = 16810311.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / calponin; 9007-34-5 / Collagen; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.6.4.1 / Myosin Heavy Chains
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63. Kamal BA: Basaloid carcinoma of epididymis. Urology; 2005 Jun;65(6):1227

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid carcinoma of epididymis.
  • A case of basaloid carcinoma of the right epididymis in a 22-year-old Saudi man is described.
  • The tumor cells were rather uniform and basaloid and contained many abnormal mitoses.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Epididymis. Genital Neoplasms, Male / pathology

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  • (PMID = 15922440.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Florentine BD, Fink T, Avidan S, Braslavsky D, Raza A, Cobb CJ: Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases. Diagn Cytopathol; 2006 Jul;34(7):491-4
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases.
  • Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area.
  • When ACC presents outside of these locations, the diagnosis may become more challenging.
  • In conclusion, ACC can present in various body sites and cytologists must consider this neoplasm when presented with a basaloid carcinoma of uncertain origin.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Pleural Effusion / pathology

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16783770.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Ooi CG, James CL, Huilgol SC: Metastatic Bowen carcinoma. Australas J Dermatol; 2006 Nov;47(4):277-80
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  • [Title] Metastatic Bowen carcinoma.
  • A 72-year-old man presented with basaloid squamous cell carcinoma metastatic to both lungs that was morphologically similar to recurrent, invasive moderately to poorly differentiated carcinoma arising from persistent Bowen's disease of the right cheek.
  • The original lesion of invasive moderately differentiated squamous cell carcinoma arising in Bowen's disease had been excised 11 years previously.
  • He died of respiratory failure 19 months following diagnosis of his metastatic disease.
  • Our case reflects the potentially aggressive nature of invasive squamous cell carcinoma arising from Bowen's disease and highlights the importance of approaching this entity with a view to complete surgical excision with adequate margins.
  • [MeSH-major] Bowen's Disease / diagnosis. Lung Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Cheek / pathology. Diagnosis, Differential. Fatal Outcome. Humans. Male. Neoplasm Metastasis

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  • (PMID = 17034472.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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66. Antoine M: [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment]. Rev Pneumol Clin; 2007 Jun;63(3):183-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment].
  • We detail here the contribution of IHC to the classification of lung cancer: small-cell lung cancer and other neuroendocrine tumors, basaloid carcinoma, large-cell carcinoma.
  • The distinction is less clear for large-cell carcinoma or squamous-cell carcinoma, or for tumors with a pleural or mediastinal presentation.
  • IHC is also useful as a diagnostic aid for rare entities: carcinomas with an unusual morphology (alpha-fetoproetin secretors or beta-HCG secretors), melanomas, lymphomas, sarcomas.
  • Other morphological techniques such as hybridization in situ or molecular biology techniques will further complete the histological diagnosis in the future.
  • [MeSH-minor] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carcinoma, Large Cell / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / pathology. Chorionic Gonadotropin, beta Subunit, Human / analysis. Forecasting. Humans. Lymph Nodes / pathology. Lymphoma / pathology. Mediastinal Neoplasms / pathology. Melanoma / pathology. Neoplasm Staging. Neuroendocrine Tumors / pathology. Pleural Neoplasms / pathology. Prognosis. Sarcoma / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 17675942.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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67. Hirai K, Koizumi K, Hirata T, Yamagishi S, Shimizu K, Kawamoto M: Basaloid carcinoma of the lung. Jpn J Thorac Cardiovasc Surg; 2005 May;53(5):263-5
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid carcinoma of the lung.
  • Basaloid carcinoma (BC) of the lung is a rare and an aggressive subtype of non small cell lung cancer.
  • We report a patient with preoperative cytologic features of either lung BC or squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Transitional Cell / surgery. Lung Neoplasms / surgery

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  • [Cites] Cancer. 1994 Jun 1;73(11):2734-9 [8194014.001]
  • [Cites] Acta Cytol. 1995 May-Jun;39(3):539-42 [7762348.001]
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  • (PMID = 15952319.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Velazquez EF, Melamed J, Barreto JE, Aguero F, Cubilla AL: Sarcomatoid carcinoma of the penis: a clinicopathologic study of 15 cases. Am J Surg Pathol; 2005 Sep;29(9):1152-8
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  • [Title] Sarcomatoid carcinoma of the penis: a clinicopathologic study of 15 cases.
  • Sarcomatoid carcinomas are uncommon, high-grade tumors, predominantly composed of spindle cells.
  • A total of 400 cases of squamous cell carcinoma of the penis were reviewed from which 15 sarcomatoid carcinomas (4%) were identified.
  • Four cases showed a minor mixed component of usual, papillary, verrucous, and basaloid carcinoma.
  • One of the cases was multicentric with a separate independent focus of well-differentiated carcinoma with pseudohyperplastic features.
  • In conclusion, penile sarcomatoid carcinomas are unusual, large, and aggressive tumors usually associated with lymph node metastasis and poor outcome.
  • Diffuse immunoreactivity for p53, compared with a more basal and focal reactivity in differentiated squamous cell carcinoma, may be indicative of a late mutation in the natural progression of the disease.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged

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  • (PMID = 16096403.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Jani P, Chetty R, Ghazarian DM: An unusual composite pilomatrix carcinoma with intralesional melanocytes: differential diagnosis, immunohistochemical evaluation, and review of the literature. Am J Dermatopathol; 2008 Apr;30(2):174-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual composite pilomatrix carcinoma with intralesional melanocytes: differential diagnosis, immunohistochemical evaluation, and review of the literature.
  • We report a case of an extremely rare histologic combination of pilomatrix or pilomatrical carcinoma with admixed melanocytes within the same tumor mass.
  • Pilomatrix carcinoma is a neoplasm of low-grade malignancy that is characterized by a tendency for recurrence but low risk of metastasis.
  • Histologically, it was typified by asymmetry and poor circumscription, the presence of several variably sized and shaped basaloid aggregations, and surface ulceration.
  • The tumors were composed of pleomorphic basaloid cells with prominent nucleoli and frequent mitoses (some of which were atypical) accompanied by central areas with keratotic material, shadow cells, and foci of necrosis.
  • In addition, intermingled with the pilomatrix carcinoma, several easily identified pigmented cells with dendritic processes were present singly and as small aggregates.
  • Pilomatrix carcinoma with melanocytes should be distinguished from the conventional pilomatrixoma with pigmentation, melanocytic matricoma, melanoma, and pigmented basal cell carcinoma with matrical differentiation.
  • Clinicians and pathologists should be aware of the occurrence of pilomatrix carcinoma with melanocytes because of its potential for diagnosis as melanoma.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Hair Diseases / pathology. Melanocytes / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Nose. Risk Assessment. Treatment Outcome

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  • (PMID = 18360125.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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70. Li N, Wolgamot G, Argenyi Z: Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma. J Cutan Pathol; 2007 May;34(5):410-4
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  • [Title] Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma.
  • Although primary cutaneous neuroendocrine cell carcinoma [Merkel cell carcinoma (MCC)] may show divergent features, including microcystic ('tubuloglandular'), squamous, eccrine and rhabdomyoblastic, a diffuse microcystic pattern is exceedingly rare.
  • In this study, we present two cases of MCC with prominent microcystic features, which precluded a definitive diagnosis in the initial punch biopsy.
  • Punch biopsies from both patients revealed an infiltrating neoplasm with prominent microcystic features that mimick tubuloglandular structures, lined by hyperchromatic basaloid cells, which were strongly positive for chromogranin and BerEP4, variably positive for CK7 and CK5/6 and negative for CK20, synaptophysin, S-100, epithelial membrane antigen (EMA), gross cystic disease fluid protein-15 (GCDFP-15), estrogen/progesterone receptors (ER/PR), thyroid transcription factor 1 (TTF1) and carcinoembryonic antigen (CEA).
  • Although the lack of CK20 staining is unusual, the histologic characteristics along with the remaining immunohistochemical studies favor the diagnosis of a primary cutaneous neuroendocrine cell carcinoma over the variants of eccrine carcinoma or basal cell carcinoma with neuroendocrine differentiation.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Eccrine Glands / pathology. Humans. Immunohistochemistry. Male. Neck / pathology

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  • (PMID = 17448197.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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71. Teramoto N, Nishimura R, Saeki T, Nogawa T, Hiura M: Adenoid basal carcinoma of the uterine cervix: report of two cases with reference to adenosquamous carcinoma. Pathol Int; 2005 Jul;55(7):445-52
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid basal carcinoma of the uterine cervix: report of two cases with reference to adenosquamous carcinoma.
  • Adenoid basal carcinoma (ABC) of the uterine cervix is a rare neoplasm with excellent prognosis.
  • Differential diagnosis between ABC and an ABC-like lesion of adenosquamous cell carcinoma (ASC) of the cervix is important due to their contrasting prognosis.
  • The two ABC were incidentally found in the uterine cervix of 69-year-old and 59-year-old Japanese women due to cervical intraepithelial neoplasia grade 3 and to squamous cell carcinoma, respectively.
  • The ABC consisted of infiltrating nests of basaloid cells with low nuclear atypia.
  • An ABC-like lesion was defined as basaloid cell nests simulating ABC, but with some features indicating malignant potential.
  • However, the differential diagnosis was sometimes difficult because two of seven ABC-like lesions were originally diagnosed as ABC.
  • Immunohistochemically, cytokeratin 7 was negative for the basaloid cells of two ABC, but positive for six of six ABC-like lesions of ASC, while cytokeratin 8 was positive for both ABC and ASC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-7. Keratin-8. Keratins / analysis. Ki-67 Antigen / analysis. Middle Aged

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  • (PMID = 15982222.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / KRT8 protein, human; 0 / Keratin-7; 0 / Keratin-8; 0 / Ki-67 Antigen; 68238-35-7 / Keratins
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72. Dardick I, Daley TD, McComb RJ: Sialoblastoma in adults: distinction from adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jan;109(1):109-16
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  • [Title] Sialoblastoma in adults: distinction from adenoid cystic carcinoma.
  • No adult cases have been reported with a specific diagnosis of sialoblastoma.
  • If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma.
  • Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development.
  • Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma.
  • Aspects of the histological differential diagnosis of these 2 tumors are discussed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Facial Paralysis / etiology. Female. Humans. Male. Middle Aged. Palate, Hard / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19880331.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Córdoba A, Guerrero D, Larrinaga B, Iglesias ME, Arrechea MA, Yanguas JI: Bcl-2 and CD10 expression in the differential diagnosis of trichoblastoma, basal cell carcinoma, and basal cell carcinoma with follicular differentiation. Int J Dermatol; 2009 Jul;48(7):713-7
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  • [Title] Bcl-2 and CD10 expression in the differential diagnosis of trichoblastoma, basal cell carcinoma, and basal cell carcinoma with follicular differentiation.
  • BACKGROUND: Both trichoblastoma and basal cell carcinoma (BCC) of the skin are characterized morphologically by the proliferation of basaloid cells; however, BCCs are clinically associated with a more aggressive behavior.
  • An accurate diagnosis of these lesions is essential for effective, timely treatment and appropriate therapeutic decisions.
  • RESULTS: Bcl-2 is useful for the detection of BCC with diffuse expression in nests of basaloid cells, but cannot distinguish between BCC with follicular differentiation and trichoblastoma, as both lesions show the same pattern with positive and negative areas.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / pathology. Neprilysin / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Diseases / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Differentiation. Cell Division. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 19570076.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2; EC 3.4.24.11 / Neprilysin
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74. Goto H, Yamamoto T, Ishiyama Z, Usui M, Okada S: Adenoid cystic carcinoma arising from the lower eyelid. Jpn J Ophthalmol; 2006 Jul-Aug;50(4):374-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma arising from the lower eyelid.
  • BACKGROUND: Primary cutaneous adenoid cystic carcinoma is one of the rarest eyelid tumors.
  • OBSERVATIONS: Under a clinical diagnosis of chalazion, the eyelid induration was extracted surgically via the palpebral conjunctiva.
  • Histopathological examination of the extracted tumor revealed proliferation of basaloid cells with a prominent cribriform pattern containing Alcian blue-positive and periodic acid Schiff-positive material, leading to a diagnosis of adenoid cystic carcinoma.
  • CONCLUSIONS: Adenoid cystic carcinoma should be considered as a differential diagnosis of eyelid tumors simulating chalazion.
  • Adenoid cystic carcinoma in the eyelid may have a more favorable prognosis than that in the lacrimal gland.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Ophthalmologic Surgical Procedures

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  • [Copyright] Copyright (c) Japanese Ophthalmological Society 2006.
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  • (PMID = 16897224.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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75. Noske A, Schwabe M, Pahl S, Fallenberg E, Richter-Ehrenstein C, Dietel M, Kristiansen G: Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma. Virchows Arch; 2008 May;452(5):575-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma.
  • Metaplastic carcinoma of the breast is a heterogeneous neoplasia, generally composed of both epithelial and mesenchymal components.
  • We report an unusual case of mammary metaplastic carcinoma in a 51-year-old female patient.
  • The resection specimen revealed a multi-directional tumour differentiation consisting predominantly of: firstly, a poorly differentiated basaloid epithelial cell type, consistent with an adenoid cystic carcinoma; secondly, areas of a spindle cell carcinoma; and, thirdly, areas with a melanocytic differentiation.
  • This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Cell Transformation, Neoplastic / pathology. Melanoma / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Metaplasia / diagnosis. Metaplasia / pathology. Middle Aged

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  • (PMID = 18283489.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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76. Mistrangelo M, Bellò M, Mobiglia A, Beltramo G, Cassoni P, Milanesi E, Cornaglia S, Pelosi E, Giunta F, Sandrucci S, Mussa A: Feasibility of the sentinel node biopsy in anal cancer. Q J Nucl Med Mol Imaging; 2009 Feb;53(1):3-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Histology revealed 23 squamous carcinomas, 10 basaloid carcinomas, 1 squamous carcinoma with basaloid areas and 1 spinocellular epithelioma associated with areas of Bowen's disease.
  • CONCLUSIONS: Given the correlation between prognosis and node involvement, sentinel node biopsy can be considered a simple method for adequate pretreatment staging of anal carcinoma.
  • [MeSH-major] Anus Neoplasms / diagnosis. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Follow-Up Studies. Humans. Inguinal Canal / pathology. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neoplasm Staging. Recurrence

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  • (PMID = 18337684.001).
  • [ISSN] 1824-4785
  • [Journal-full-title] The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology
  • [ISO-abbreviation] Q J Nucl Med Mol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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77. Mastropasqua MG, Maiorano E, Pruneri G, Orvieto E, Mazzarol G, Vento AR, Viale G: Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. Mod Pathol; 2005 Oct;18(10):1277-82
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  • [Title] Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast.
  • Adenoid cystic carcinoma of the breast represents a unique clinicopathologic entity with a variable histological appearance and a relatively indolent clinical course in most of the cases.
  • Adenoid cystic carcinoma may be difficult to differentiate from infiltrating duct carcinomas, and in particular from tubular and cribriform carcinomas, especially in core or vacuum-assisted biopsies.
  • We evaluated the prevalence of c-kit, p63, and e-cadherin immunoreactivity in a series of 20 adenoid cystic carcinomas, comparing the results with those obtained in a series of infiltrating tubular carcinomas and infiltrating cribriform carcinomas.
  • Three (15%) adenoid cystic carcinomas and all infiltrating tubular and cribriform carcinomas showed estrogen receptor and/or progesterone receptor immunoreactivity (P < 0.00001 for estrogen and P = 0.00002 for progesterone receptors).
  • Adenoid cystic carcinomas consistently lacked any immunoreactivity for HER/2, whereas three (15%) infiltrating and cribriform carcinomas showed weak and incomplete membrane staining (P = 0.23077).
  • Membranous immunoreactivity for c-kit was found in all except one (predominantly basaloid) adenoid cystic carcinomas (95%), and in none of the infiltrating tubular and cribriform carcinomas (P < 0.00001).
  • Nuclear immunoreactivity for p63 was found in all except three (predominantly basaloid) adenoid cystic carcinomas (85%) and in none of the infiltrating tubular and cribriform carcinomas (P < 0.00001).
  • All infiltrating tubular and cribriform carcinomas and 18/20 (90%) adenoid cystic carcinomas showed immunoreactivity for e-cadherin (P = 0.48718).
  • In summary, adenoid cystic carcinomas showed the following phenotype: estrogen receptor-/progesterone receptor-/c-kit+/p63+ (13 cases, 65%), estrogen receptor-/progesterone receptor/c-kit+/p63- (three cases, 15%), estrogen receptor-/progesterone receptor-/c-kit-/p63+ (one case, 5%), estrogen receptor+/progesterone receptor+/c-kit+/p63+ (two cases, 10%), and estrogen receptor+/progesterone receptor-/c-kit+/p63+ (one case).
  • By contrast, all the infiltrating tubular and cribriform carcinomas showed the estrogen receptor+/progesterone receptor+/c-kit-/p63- phenotype.
  • Our data provide evidence that immunoreactivity for c-kit and/or p63 may be useful in differentiating adenoid cystic carcinomas from other types of breast cancer.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Membrane Proteins / metabolism. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 15846389.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Cadherins; 0 / Membrane Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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78. Fresini A, Rossiello L, Severino BU, Del Prete M, Satriano RA: Giant basal cell carcinoma. Skinmed; 2007 Jul-Aug;6(4):204-5
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  • [Title] Giant basal cell carcinoma.
  • The tumor mostly showed an adenoid pattern: gland-like structures and cystic spaces sometimes containing amorphous or granular material, surrounded by strands of basaloid cells devoid of any peripheral palisading (Figure 2C).
  • In some areas, the adenoid pattern coexisted with infiltrated areas characterized by thin and elongated strands or cords of basaloid cells with irregular and jagged peripheral contours within a fibrous or edematous stroma (Figure 2D).
  • Basaloid cells often revealed nuclear atypia, marked pleomorphism and hyperchromatism (Figure 2C and Figure 2D).
  • Therefore, a diagnosis of basal cell carcinoma, adenoid subtype, was made.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 17618177.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Batrani M, Kaushal M, Sen AK, Yadav R, Chaturvedi NK: Pleomorphic adenoma with squamous and appendageal metaplasia mimicking mucoepidermoid carcinoma on cytology. Cytojournal; 2009;6:5

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  • [Title] Pleomorphic adenoma with squamous and appendageal metaplasia mimicking mucoepidermoid carcinoma on cytology.
  • Fine needle aspiration cytology showed squamous cells, basaloid cells, and foamy cells, along with extracellular keratin and foreign body giant cells.
  • A diagnosis of mucoepidermoid carcinoma was given on cytology.
  • CONCLUSION: This case illustrates that pleomorphic adenoma with squamous metaplasia presents a potential for misinterpretation as mucoepidermoid carcinoma on cytology.

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  • [Cites] Otolaryngol Head Neck Surg. 2005 Dec;133(6):987-8 [16360528.001]
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  • (PMID = 19495404.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2678828
  • [Keywords] NOTNLM ; Mucoepidermoid carcinoma / pleomorphic adenoma / squamous metaplasia
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80. Pereira MC, Oliveira DT, Landman G, Kowalski LP: Histologic subtypes of oral squamous cell carcinoma: prognostic relevance. J Can Dent Assoc; 2007 May;73(4):339-44
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  • [Title] Histologic subtypes of oral squamous cell carcinoma: prognostic relevance.
  • Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity.
  • The conventional tumour and several histologic subtypes of SCC present morphologic features and specific behaviour when they occur in the oral mucosa.
  • For example, basaloid SCC is an aggressive tumour and verrucous carcinoma has the lowest invasive and metastatic potential; however, the clinical and biologic course of these oral SCC variants has not been completely established.
  • The purpose of this article is to review the various subtypes of oral SCC, emphasizing problems in their histologic diagnosis and prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basosquamous / pathology. Carcinoma, Verrucous / pathology. Humans. Prognosis


81. Pham TT, Selim MA, Burchette JL Jr, Madden J, Turner J, Herman C: CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol; 2006 Feb;33(2):123-8
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  • [Title] CD10 expression in trichoepithelioma and basal cell carcinoma.
  • BACKGROUND: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC).
  • Of these, eight cases also demonstrated positivity of the papilla, and two also showed positivity of the basaloid cells.
  • On the other hand, expression of CD10 by basaloid cells was identified in 20 (87%) cases of BCC.
  • Condensation of CD10-positive stromal cells around basaloid nests was statistically significant in differentiating TE from BCC (p < 0.0001).
  • Conversely, CD10-positive basaloid cells were seen predominantly in BCC (p < 0.0001).
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / metabolism. Neoplasms, Basal Cell / metabolism. Neprilysin / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 16420307.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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82. Scurry J, Wilkinson EJ: Review of terminology of precursors of vulvar squamous cell carcinoma. J Low Genit Tract Dis; 2006 Jul;10(3):161-9
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  • [Title] Review of terminology of precursors of vulvar squamous cell carcinoma.
  • The popular term for vulvar squamous cell carcinoma in situ/dysplasia is vulvar intraepithelial neoplasia (VIN).
  • VIN is a histological diagnosis based on loss of squamous epithelial maturation associated with enlarged, hyperchromatic, pleomorphic nuclei and increased, usually atypical mitoses.
  • There are two types of VIN: the usual (not otherwise specified) type, also known as warty-basaloid, and the differentiated type.
  • There are 3 grading systems for warty-basaloid VIN: the traditional 3-grade system of VIN 1-3, a low-grade/high grade Bethesda-like system and the International Society for the Study of Vulvovaginal Disease's proposal for only 1 grade.
  • The ISSVD system eliminates VIN 1 and combines VIN 2 and 3 on the grounds that VIN 1 has not been shown to be a reproducible diagnosis and VIN 2 and 3 are not reliably separated.
  • Warty basaloid VIN may be sub-typed into warty and basaloid VIN.
  • Warty-basaloid VIN may regress.
  • Differentiated VIN has been typically diagnosed co-incident with squamous cell carcinoma.
  • With increased frequency of performance of biopsy of hyperplastic lesions, differentiated VIN should be diagnosed more commonly before squamous carcinoma occurs.
  • [MeSH-major] Carcinoma in Situ / classification. Carcinoma, Squamous Cell / classification. Precancerous Conditions / classification. Terminology as Topic. Vulvar Neoplasms / classification

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  • [CommentIn] J Low Genit Tract Dis. 2006 Jul;10(3):135-6 [16829750.001]
  • (PMID = 16829756.001).
  • [ISSN] 1089-2591
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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83. Quintyn-Ranty ML, Escourrou G, Guilbeau C, Rimailho J, Delisle MB: [Vaginal adenoid cystic carcinoma: a case report]. Ann Pathol; 2008 Apr;28(2):135-7
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  • [Title] [Vaginal adenoid cystic carcinoma: a case report].
  • Adenoid cystic carcinoma generally arises from the salivary glands and is rarely found in the female genital tract.
  • Differential diagnosis includes adenoid basal carcinoma, polymorphous low-grade adenocarcinoma and basaloid squamous cell carcinoma.
  • We report a case of adenoid cystic carcinoma in a 48-year-old woman with previous cervical HPV infection.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18675169.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Actins
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84. Nishioka M, Tanemura A, Yamanaka T, Tani M, Miura H, Asakura M, Tamai N, Katayama I: Pilomatrix carcinoma arising from pilomatricoma after 10-year senescent period: Immunohistochemical analysis. J Dermatol; 2010 Aug;37(8):735-9
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  • [Title] Pilomatrix carcinoma arising from pilomatricoma after 10-year senescent period: Immunohistochemical analysis.
  • Pilomatrix carcinoma is a rare malignant counterpart of pilomatricoma.
  • Pilomatrix carcinoma is locally aggressive and occasionally shows rapid progression infiltrating to the muscle, bone and vessels.
  • We report a case of pilomatrix carcinoma that developed in a 38-year-old man and started to grow after a long stable period, relapsed for a short time and infiltrated into the muscle underneath.
  • Although it is still controversial whether pilomatrix carcinoma arises de novo or through malignant transformation of a pilomatricoma, the present case might be caused by the latter process considering the patient's clinical course. beta-catenin is a downstream effecter in the canonical pathway of Wnt, acting as a signal for cell differentiation and proliferation.
  • The characteristic nuclear staining pattern of beta-catenin in the basaloid tumor cells, which is usually observed in pilomatrix carcinoma, supported the diagnosis of pilomatrix carcinoma in the present case.
  • [MeSH-major] Carcinoma / diagnosis. Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20649718.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / beta Catenin
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85. Cabibi D, Cipolla C, Maria Florena A, Fricano S, Barresi E, Vieni S, Rodolico V, Napoli L: Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma". Pathol Res Pract; 2005;201(10):705-11
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  • [Title] Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma".
  • We describe a rare case of a solid variant of a mammary adenoid cystic carcinoma with basaloid features (sbACC) and its coexistence with a "small cell" carcinoma (SCC), identified and confirmed by histological and immunohistochemical observations: the absence of glandular structures and PAS-positive globules, positivity for neuroendocrine markers (NSE, synaptophysin and chromogranin), and negativity for 34betaE12 and SMA actin were the aspects suggesting the presence of SCC.
  • To our knowledge, this is the first reported case of a solid basaloid adenoid cystic carcinoma merging with an SCC carcinoma.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Small Cell / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16325513.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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86. Merritt BG, Snow SN, Longley BJ: Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery. Cutis; 2010 May;85(5):254-8
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  • [Title] Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery.
  • Several important cutaneous neoplasms present with basaloid cells in the dermis.
  • Desmoplastic trichoepithelioma (DTE), infiltrative/morpheaform basal cell carcinoma (BCC), and microcystic adnexal carcinoma (MAC) are tumors in this category that may be difficult to differentiate, especially when evaluating thin biopsy specimens.
  • An accurate diagnosis has important clinical implications.
  • We present a patient with an unusual tumor demonstrating basaloid cells in the dermis and discuss the diagnostic approach for these lesions, emphasizing the potential role of cytokeratin 20 (CK20) in determining the need for Mohs micrographic surgery.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / pathology. Mohs Surgery. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-20. Male. Middle Aged. Staining and Labeling

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  • (PMID = 20540416.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20
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87. Basile JR, Lin YL: A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Apr;109(4):e28-33
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  • [Title] A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma.
  • The microcystic adnexal carcinoma (MAC) is a rare, slow-growing but locally aggressive neoplasm arising in the midface and lips of middle-aged adults.
  • The MAC is histologically characterized by deeply infiltrating nests and islands of basaloid or squamous cells forming cysts and ductal structures, proliferating in a dense sclerotic stroma and occasionally exhibiting perineural invasion.
  • The diagnostic dilemma presented by this lesion is discussed, along with a differential diagnosis and brief review of the literature.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Skin Appendage / pathology. Lip Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Biopsy. Cell Nucleus / ultrastructure. Cell Proliferation. Connective Tissue / pathology. Cytoplasm / ultrastructure. Diagnosis, Differential. Female. Fibrosis. Humans. Lip / innervation. Middle Aged. Neoplasm Invasiveness. Sclerosis

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):284-6 [21684772.001]
  • (PMID = 20303043.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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88. Lamovec J, Falconieri G, Salviato T, Pizzolitto S: Basaloid carcinoma of the breast: a review of 9 cases, with delineation of a possible clinicopathologic entity. Ann Diagn Pathol; 2008 Feb;12(1):4-11
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  • [Title] Basaloid carcinoma of the breast: a review of 9 cases, with delineation of a possible clinicopathologic entity.
  • Basaloid carcinoma of the breast (BCB) is an unusual neoplasm composed of basal-type neoplastic cells similar to those found in adenoid cystic carcinoma (ACC), although lacking distinctive features such as a cribriform pattern, a dual neoplastic population (epithelial-myoepithelial/basaloid), and stromal deposits of basement membrane-like material.
  • In this article, we present 9 cases of breast cancer showing overall/predominant basaloid morphology.
  • Microscopically, they featured sheets, nests, and cords of proliferating basaloid tumor cells with ovoid, hyperchromatic nuclei with inconspicuous nucleoli and scant cytoplasm.
  • Transition into pleomorphic basaloid carcinoma with foci of high-grade ductal carcinoma in situ plus infiltrating ductal carcinoma (IDC) and admixture with grade 3 ductal and sarcomatoid carcinoma was seen in 2 cases.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Transitional Cell / pathology

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  • (PMID = 18164408.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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89. Begnami MD, Quezado M, Pinto P, Linehan WM, Merino M: Adenoid cystic/basal cell carcinoma of the prostate: review and update. Arch Pathol Lab Med; 2007 Apr;131(4):637-40
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  • [Title] Adenoid cystic/basal cell carcinoma of the prostate: review and update.
  • CONTEXT: Although most prostate carcinomas are of the conventional acinar type, unusual variants have been reported.
  • Adenoid cystic/basal cell carcinoma of the prostate is a rare tumor with distinctive histopathologic features.
  • There are only a few publications in the literature concerning the diagnosis, treatment, and prognosis of this neoplasm.
  • OBJECTIVE: To review current literature together with the clinical, pathologic, and immunohistochemical features of adenoid cystic/basal cell carcinoma of the prostate and offer a practical approach to the diagnosis--including the differential diagnosis--of this neoplasm in surgical pathologic specimens.
  • DATA SOURCES: Adenoid cystic/basal cell carcinoma of the prostate is composed of infiltrating basaloid cells forming dilated acinar and cribriform spaces with luminal basementlike material.
  • Differentiation of adenoid cystic/basal cell carcinoma from basal cell hyperplasia and cribriform pattern of acinar adenocarcinoma may be difficult.
  • CONCLUSIONS: Various histologic and immunohistochemical features are helpful in recognizing adenoid cystic/basal cell carcinoma of the prostate.
  • This is a rare subtype of prostate cancer and correct diagnosis is important because of the unique clinical and biological features and the implications for treatment and prognosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 17425398.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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90. Fischer S, Breuninger H, Metzler G, Hoffmann J: Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg; 2005 Jan;16(1):53-8
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  • [Title] Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor.
  • Microcystic adnexal carcinoma (MAC) belongs to the spectrum of locally aggressive adnexal carcinomas and most commonly occurs in the head and neck region.
  • In 1982, Goldstein and colleagues first reported MAC to be a distinct histologic entity characterized by a combination of keratinous cysts in the upper dermis, islands and strands of small basaloid, benign-appearing keratinocytes or squamous cells in the deeper dermis within a dense desmoplastic stroma, and areas of ductular differentiation.
  • The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time.
  • Previous histopathologic diagnoses were squamous cell carcinoma and desmoplastic trichoepithelioma.
  • Local recurrences of the tumor occurred, despite histographic surgery because in hematoxylin and eosin stains, small islands of the deceptively benign-appearing small basaloid cells of MAC were not recognized as tumor cells.
  • The reported case demonstrates the difficulties in diagnosing MAC and indicates that MAC should always be considered in the differential diagnosis of slowly growing tumors in the head and neck region.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Basal Cell / pathology

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  • (PMID = 15699645.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Ball NJ, Tanhuanco-Kho G: Merkel cell carcinoma frequently shows histologic features of basal cell carcinoma: a study of 30 cases. J Cutan Pathol; 2007 Aug;34(8):612-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma frequently shows histologic features of basal cell carcinoma: a study of 30 cases.
  • BACKGROUND: Merkel cell carcinoma (MCC) is a basaloid cutaneous neoplasm that may be mistaken for basal cell carcinoma (BCC).
  • Squamous cell carcinoma was identified in four cases (13%).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Merkel Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers. Biopsy. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • [CommentIn] J Cutan Pathol. 2008 Aug;35(8):789-90 [18687075.001]
  • (PMID = 17640231.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers
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92. Yu L, Galan A, McNiff JM: Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma. J Cutan Pathol; 2009 Oct;36(10):1074-176
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma.
  • BACKGROUND: Superficial skin biopsies of basal cell carcinoma (BCC) represent some of the most common dermatopathology specimens.
  • Superficial shave biopsies containing partial samples of lesions with squamatization present difficulties in distinguishing BCC from squamous cell carcinoma (SCC).
  • RESULTS: We found that all cases (12 out of 12) showed membranous and cytoplasmic staining with BerEP4 in the obvious areas of basaloid differentiation at the periphery of the tumors, while cords and strands of enlarged cells with squamoid features in the center and surface of the biopsy failed to label with BerEP4.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Staining and Labeling

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  • [Copyright] 2009 John Wiley & Sons A/S.
  • (PMID = 19187107.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / human epithelial antigen-125
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93. Agero AL, Busam KJ, Benvenuto-Andrade C, Scope A, Gill M, Marghoob AA, González S, Halpern AC: Reflectance confocal microscopy of pigmented basal cell carcinoma. J Am Acad Dermatol; 2006 Apr;54(4):638-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reflectance confocal microscopy of pigmented basal cell carcinoma.
  • OBJECTIVE: We sought to describe the relevant RCM features for pigmented basal cell carcinoma (BCC).
  • METHODS: Pigmented skin lesions with a differential diagnosis of pigmented BCC were imaged using dermoscopy and RCM, followed by excision for histologic analysis.
  • RESULTS: RCM demonstrated aggregations of tightly packed cells with palisading, forming cordlike structures and nodules with irregular borders and variable brightness; these represented nests of pigmented basaloid tumor cells on histopathology, and blue-gray ovoid areas on dermoscopy.
  • CONCLUSION: RCM may permit in vivo diagnosis of pigmented BCC.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Melanoma / diagnosis. Melanoma / pathology. Microscopy, Confocal. Middle Aged

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  • (PMID = 16546585.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Hudson E, Rashid M, Carter AC, Lester JF: Basaloid carcinoma of the prostate: a case report and review of the literature. Eur J Cancer Care (Engl); 2008 Sep;17(5):509-11
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  • [Title] Basaloid carcinoma of the prostate: a case report and review of the literature.
  • We report a case of infiltrative basaloid carcinoma of the prostate in a 68-year old man that did not respond to systemic chemotherapy.
  • It is essential that this aggressive disease is differentiated from more indolent basaloid proliferations, as metastatic spread can occur and outcome may be poor.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 18616505.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 7
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95. Sakakura N, Tateyama H, Usami N, Yokoi K: Thymic basaloid carcinoma with pleural dissemination that developed after a curative resection: report of a case. Surg Today; 2010 Nov;40(11):1073-8
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  • [Title] Thymic basaloid carcinoma with pleural dissemination that developed after a curative resection: report of a case.
  • Thymic basaloid carcinoma is an extremely rare tumor type, with only 10 such reports published to date in the English literature.
  • We herein present a new case of thymic basaloid carcinoma with pleural dissemination that developed after a curative resection.
  • The present case and the review of previous cases indicated that this rare tumor, which had previously been considered to be a low-grade malignant thymic carcinoma, may therefore have a more obstinate and aggressive malignant nature.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Pleural Neoplasms / secondary. Thymus Neoplasms / pathology

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  • [Cites] Ann Thorac Surg. 1999 Nov;68(5):1863-5 [10585082.001]
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  • (PMID = 21046508.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Proto-Oncogene Proteins c-bcl-2; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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96. Ueda M, Ashida M, Kunisada M, Ichihashi M, Sata T, Matsukura T: Bowen's carcinoma of the scrotal skin associated with human papillomavirus type 82. J Eur Acad Dermatol Venereol; 2005 Mar;19(2):232-5
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  • [Title] Bowen's carcinoma of the scrotal skin associated with human papillomavirus type 82.
  • Histopathologically, the lesion was composed of two distinct parts; one part showing changes characteristic of Bowen's disease in the epidermis, and the other showing elongated rete ridges and proliferation of atypical basaloid cells in the dermis.
  • These parts were partially connected, giving the diagnosis of Bowen's carcinoma.

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  • (PMID = 15752300.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Viral
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97. Segura S, Puig S, Carrera C, Palou J, Malvehy J: Dendritic cells in pigmented basal cell carcinoma: a relevant finding by reflectance-mode confocal microscopy. Arch Dermatol; 2007 Jul;143(7):883-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dendritic cells in pigmented basal cell carcinoma: a relevant finding by reflectance-mode confocal microscopy.
  • BACKGROUND: Reflectance-mode confocal microscopy (RCM) is a new approach for the in vivo diagnosis of skin tumors.
  • A few studies of RCM on basal cell carcinoma (BCC) have provided specific diagnostic criteria, but large studies on pigmented basal cell carcinoma are lacking.
  • Proliferation of large dendritic-shaped cells within a melanocytic tumor has been associated with the diagnosis of melanoma by RCM.
  • Leaf-like areas observed on dermoscopy correlated with low-refractive cordlike structures and nodules by RCM and corresponded to nests of basaloid cells, whereas blue-gray globules presented as bright oval structures with ill-defined borders corresponding to melanophages.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Dendritic Cells / cytology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Melanoma / diagnosis. Melanoma / pathology. Microscopy, Confocal

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  • (PMID = 17638732.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Østergaard J, Boberg-Ans J, Prause JU, Heegaard S: Primary basal cell carcinoma of the caruncle with seeding to the conjunctiva. Graefes Arch Clin Exp Ophthalmol; 2005 Jun;243(6):615-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary basal cell carcinoma of the caruncle with seeding to the conjunctiva.
  • BACKGROUND: To report the clinical and histopathological characteristics of a patient with a primary basal cell carcinoma (BCC) of the caruncle with seeding of the tumour to the conjunctiva.
  • Microscopically, both neoplasms were composed of infiltrative islands of basaloid tumour cells, scattered mitoses and peripheral palisading consistent with the diagnosis of BCC.
  • [MeSH-major] Carcinoma, Basal Cell / secondary. Conjunctival Neoplasms / secondary. Lacrimal Apparatus / pathology. Lacrimal Apparatus Diseases / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Eye Neoplasms / pathology. Eye Neoplasms / surgery. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Metastasis. Ophthalmologic Surgical Procedures / methods. Tomography, X-Ray Computed

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  • [Cites] Surv Ophthalmol. 1993 Sep-Oct;38(2):169-92 [8235999.001]
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  • (PMID = 15614536.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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99. Smrkovski OA, LeBlanc AK, Smith SH, LeBlanc CJ, Adams WH, Tobias KM: Carcinoma ex pleomorphic adenoma with sebaceous differentiation in the mandibular salivary gland of a dog. Vet Pathol; 2006 May;43(3):374-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma ex pleomorphic adenoma with sebaceous differentiation in the mandibular salivary gland of a dog.
  • A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog.
  • Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology.
  • The tumor was comprised of basaloid and low columnar epithelial cells, many glandular units formed by well-differentiated sebocytes, and multifocal regions of necrosis, mineralization, and hemorrhage.
  • [MeSH-major] Adenoma, Pleomorphic / veterinary. Carcinoma / veterinary. Dog Diseases / diagnosis. Salivary Gland Neoplasms / veterinary

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  • (PMID = 16672588.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Chute DJ, Stelow EB: Cytology of head and neck squamous cell carcinoma variants. Diagn Cytopathol; 2010 Jan;38(1):65-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytology of head and neck squamous cell carcinoma variants.
  • The most common diagnosis rendered with head and neck fine needle aspiration (FNA) biopsy is metastatic squamous cell carcinoma (SCC).
  • While most cases of metastatic SCC pose little diagnostic difficulty, the diagnosis of metastatic histologic variants of SCC, often coupled with less common etiologies, can be more problematic.
  • This manuscript reviews the clinicopathologic features of the histologic variants of upper aerodigestive tract SCC (verrucous, papillary, spindle cell, undifferentiated, acantholytic, and basaloid) and uncommon etiologies of head and neck SCC (human papillomavirus, Epstein-Barr Virus, and NUT midline carcinomas).
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19582815.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 122
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