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1. Desjardins L: [Benign pigmented lesions of the eyelids]. J Fr Ophtalmol; 2005 Oct;28(8):889-95
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  • [Title] [Benign pigmented lesions of the eyelids].
  • We describe benign pigmented tumors of the lids, including benign lesions of the epithelium such as papillomas, seborrheic keratosis, and inverted follicular keratosis; precancerous lesions of the epithelium such as xeroderma pigmentosum and actinic keratosis; melanocytic lesions such as Ota nevus, lentigo, and lentigo maligna; and nevi and other lesions simulating a melanoma such as pigmented hidrocystoma, angiomas, and epithelial cyst.

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  • (PMID = 16249773.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 34
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2. Thakur JS, Thakur A, Chauhan CG, Diwana VK, Chauhan DC: Giant pedunculated seborrheic keratosis of penis. Indian J Dermatol; 2008 Jan;53(1):37-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant pedunculated seborrheic keratosis of penis.
  • Seborrheic keratosis of the penis is a rare entity.
  • It has been mistaken as genital warts and differentiation is only made on histopathology.
  • Seborrheic keratosis should be considered in the differential diagnosis of pedunculated lesions of the penis.

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  • [Cites] Am J Dermatopathol. 1994 Aug;16(4):398-405; discussion 406-8 [7978069.001]
  • [Cites] Am J Dermatopathol. 1993 Feb;15(1):1-6 [8382012.001]
  • [Cites] Urology. 1974 May;3(5):595-7 [4275401.001]
  • [Cites] Am J Dermatopathol. 1989 Jun;11(3):209-12 [2543229.001]
  • [Cites] Am Fam Physician. 1986 Aug;34(2):147-52 [2944363.001]
  • [Cites] Urology. 1987 Feb;29(2):204-6 [2949418.001]
  • [Cites] JAMA. 1991 Jan 2;265(1):74-7 [1824572.001]
  • (PMID = 19967020.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2784587
  • [Keywords] NOTNLM ; Penis / seborrheic keratosis / warts
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3. Fernandez-Flores A: Irritated seborrheic keratosis with coarse keratohyalin granules. Rom J Morphol Embryol; 2009;50(4):583-7
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  • [Title] Irritated seborrheic keratosis with coarse keratohyalin granules.
  • AIMS: The viral etiology of certain types of seborrheic keratosis (SK) has been a controversial subject in literature, with different molecular results.
  • On the contrary, to the molecular approach, some have suggested that certain types of SK are indeed warts, due to their morphologic features.
  • MATERIAL, METHODS AND RESULTS: We examined the last 60 cases with such a diagnosis in our Service of Anatomic Pathology and found these granules in eight cases (7.5%).
  • In these eight cases, we also looked for other morphologic signs suggesting a viral origin, such as papilated, exo-endophytic configuration, parakeratosis at the tips of digitations, dilated vessels in the papillae and koilocytes.
  • CONCLUSIONS: We discuss the meaning of such a finding as described in literature, and conclude that it should be a specific feature to look out for, in cases of irritated SK, in order to exclude a diagnosis of verruca vulgaris.
  • [MeSH-major] Cytoplasmic Granules / pathology. Keratins / metabolism. Keratosis, Seborrheic / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Epidermis / metabolism. Epidermis / pathology. Epidermis / virology. Female. Humans. Male. Middle Aged. Parakeratosis / metabolism. Parakeratosis / pathology. Parakeratosis / virology. Warts / pathology. Warts / virology

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  • (PMID = 19942951.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / keratohyalin; 68238-35-7 / Keratins
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4. Hafner C, Hartmann A, Vogt T: FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin. J Invest Dermatol; 2007 Jul;127(7):1572-3
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  • [Title] FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin.
  • Evidence is growing that these mutations are also involved in the pathogenesis of benign acanthotic skin tumors such as epidermal nevi and seborrheic keratoses.
  • [MeSH-major] Germ-Line Mutation / genetics. Keratosis, Seborrheic / genetics. Nevus / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Skin Neoplasms / genetics. Urinary Bladder Neoplasms / genetics

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  • [CommentOn] J Invest Dermatol. 2007 Jul;127(7):1664-6 [17255960.001]
  • (PMID = 17568799.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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5. Kim JH, Bae HW, Lee KK, Kim TI, Kim EK: Seborrheic keratosis of the conjunctiva: a case report. Korean J Ophthalmol; 2009 Dec;23(4):306-8
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  • [Title] Seborrheic keratosis of the conjunctiva: a case report.
  • Seborrheic keratosis is a benign epithelial neoplasia that occurs mainly in the skin of the eyelids and face.
  • We describe a case of seborrheic keratosis of the conjunctiva confirmed by histopathology.
  • A 72-year-old man presented with a recurrent conjunctival mass involving the nasal side of his right eye.
  • Clinically, a diagnosis of conjunctival papilloma was made, and a mass excision was performed.
  • With the above findings, a diagnosis of conjunctival seborrheic keratosis was established.
  • The occurrence of seborrheic keratosis on the conjunctiva is rare.
  • In this case, seborrheic keratosis was confirmed by pathologic report despite its similar appearance with papilloma.
  • Seborrheic keratosis should be considered in the differential diagnosis of conjunctival lesions.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Keratosis, Seborrheic / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Microscopy, Acoustic. Ophthalmologic Surgical Procedures / methods

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  • [Cites] Indian J Ophthalmol. 2004 Jun;52(2):154-5 [15283223.001]
  • [Cites] Br J Ophthalmol. 1994 Apr;78(4):252-9 [8199108.001]
  • [Cites] Arch Dermatol Res. 1995;287(6):612-5 [7487151.001]
  • [Cites] Arch Soc Esp Oftalmol. 2006 Apr;81(4):217-9 [16688646.001]
  • [Cites] Surv Ophthalmol. 1998 Jan-Feb;42(4):321-50 [9493274.001]
  • [Cites] Ophthalmology. 1999 Aug;106(8):1516-20 [10442897.001]
  • [Cites] Am J Dermatopathol. 1996 Jun;18(3):278-82 [8806962.001]
  • (PMID = 20046694.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2789958
  • [Keywords] NOTNLM ; Conjunctival mass / Papilloma / Seborrheic keratosis
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6. Repertinger S, Wang J, Adickes E, Sarma DP: Melanoma in-situ arising in seborrheic keratosis: a case report. Cases J; 2008;1(1):263
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  • [Title] Melanoma in-situ arising in seborrheic keratosis: a case report.
  • BACKGROUND: Seborrheic keratosis is a very common benign skin tumor in man.
  • A melanoma arising in a seborrheic keratosis is distinctly rare.
  • We are reporting such a case occurring in an 86-year-old man.
  • CASE PRESENTATION: An-86-year-old male with a history of multiple actinic keratoses and seborrheic keratoses of the head and trunk presented with a mid-back skin lesion.
  • The biopsied lesion was composed of the usual features of hyperkeratotic seborrheic keratosis, but with focal atypical melanocytic proliferation with nesting along the dermal-epidermal junction.
  • We interpreted this lesion as a melanoma in-situ arising within a seborrheic keratosis.
  • CONCLUSION: It is not uncommon for many physicians to remove a typical seborrheic keratosis without a confirmatory microscopic confirmation.

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  • [Cites] Australas J Dermatol. 2006 May;47(2):109-13 [16637806.001]
  • [Cites] J Am Acad Dermatol. 2000 May;42(5 Pt 1):831-3 [10775864.001]
  • [Cites] Dermatol Surg. 2004 Apr;30(4 Pt 1):559-61 [15056152.001]
  • [Cites] Am J Dermatopathol. 1996 Jun;18(3):278-82 [8806962.001]
  • (PMID = 18947402.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2577645
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7. Hafner C, Hartmann A, van Oers JM, Stoehr R, Zwarthoff EC, Hofstaedter F, Landthaler M, Vogt T: FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization. Mod Pathol; 2007 Aug;20(8):895-903
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  • [Title] FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization.
  • Somatic activating fibroblast growth factor 3 (FGFR3) mutations in human skin can cause seborrheic keratoses, one of the most frequent skin tumors in man.
  • We analyzed 65 acanthotic seborrheic keratoses with varying vertical diameters for FGFR3 mutations using a SNaPshot multiplex assay.
  • Immunohistochemistry was performed for Ki-67, bcl-2 and FGFR3 protein in all seborrheic keratoses and 19 normal skin samples.
  • FGFR3 mutations were detected in 37 of 65 seborrheic keratoses (57%).
  • These mutations were found both in flat (initial) and thick seborrheic keratoses.
  • FGFR3 mutations were significantly associated with increased age and localization on the head and neck (P<0.01).
  • Ki-67 expression was significantly higher in seborrheic keratoses than in normal epidermis independent of the FGFR3 status (P<0.001).
  • Our results indicate that FGFR3 mutations can occur early in the pathogenesis of at least a subset of seborrheic keratoses.
  • Increased age appears to be a risk factor for these mutations.
  • The preferential occurrence of FGFR3 mutations in seborrheic keratoses of the head and neck suggests a causative role for cumulative lifetime ultraviolet light exposure.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Head and Neck Neoplasms / genetics. Keratosis, Seborrheic / genetics. Mutation. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Apoptosis. Cell Proliferation. DNA Mutational Analysis. Female. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / analysis. Risk Factors

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  • (PMID = 17585316.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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8. Battistella M, Peltre B, Cribier B: Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis. J Cutan Pathol; 2010 Oct;37(10):1057-63
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  • [Title] Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • BACKGROUND: Trichoblastomas (TBs) are benign follicular tumors that can present either as solitary nodule or as multiple facial papules.
  • We report the association of TB and benign epidermal/follicular neoplasm in six patients.
  • Serial sections and immunohistochemical (IHC) analysis for CK17 and human papilloma virus (HPV) were performed on available materials.
  • Mean age at diagnostic was 56 years.
  • The lesions associated with TB were inverted follicular keratosis (IFK) in three cases, seborrhoeic keratosis (SK) in two cases and IFK with verruca vulgaris pattern in one case.
  • CONCLUSION: TB can be associated with benign epidermal/follicular neoplasm in composite tumors.
  • The association of TB and IFK with direct connection between the lesions is another argument in favor of the follicular origin of IFK.
  • Composite tumors associating trichoblastoma and benign epidermal/follicular neoplasm: another proof of the follicular nature of inverted follicular keratosis.
  • [MeSH-major] Keratosis, Seborrheic / complications. Neoplasms, Multiple Primary / pathology. Skin Diseases / complications. Skin Neoplasms / complications

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  • (PMID = 19615018.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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9. Larumbe A, Iglesias ME, Illarramendi JJ, Córdoba A, Gállego M: [Acral keratoses and inverted follicular keratosis presenting Cowden disease]. Actas Dermosifiliogr; 2007 Jul-Aug;98(6):425-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acral keratoses and inverted follicular keratosis presenting Cowden disease].
  • [Transliterated title] Queratosis acras y queratosis folicular invertida como manifestación de la enfermedad de Cowden.
  • Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract.
  • Mucocutaneous lesions are the most constant and characteristic finding.
  • Inverted follicular keratosis as the presenting feature of Cowden disease is rare as the disease is usually suspected by the appearance of multiple facial trichilemmomas, oral mucosal papillomatosis and acral keratoses.
  • [MeSH-major] Hamartoma Syndrome, Multiple / diagnosis. Keratosis / etiology

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  • (PMID = 17663933.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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10. Noiles K, Vender R: Are all seborrheic keratoses benign? Review of the typical lesion and its variants. J Cutan Med Surg; 2008 Sep-Oct;12(5):203-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are all seborrheic keratoses benign? Review of the typical lesion and its variants.
  • BACKGROUND: Seborrheic keratosis (SK) is one of the more common benign epidermal neoplasms seen in adult and middle-aged patients.
  • RESULTS: Six subtypes of SK were identified: dermatosis papulosa nigra, stucco keratosis, inverted follicular keratosis, large cell acanthoma, lichenoid keratosis, and flat seborrheic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / classification. Skin Neoplasms / classification

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  • (PMID = 18845088.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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11. Vun Y, De'Ambrosis B, Spelman L, Muir JB, Yong-Gee S, Wagner G, Lun K: Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation? Australas J Dermatol; 2006 May;47(2):106-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation?
  • A retrospective study of 813 histological specimens reported as seborrhoeic keratoses included 43 (5.3%) associated with non-melanoma skin cancer.
  • Intraepidermal carcinoma (squamous cell carcinoma in situ) was the most common of these (36).
  • There were five basal cell carcinomas (one with intraepidermal carcinoma also) and two invasive squamous cell carcinomas.
  • Twenty-seven of the intraepidermal carcinomas appeared to arise within the seborrhoeic keratosis as did one of the invasive squamous cell carcinomas.
  • Fourteen were clinically diagnosed as a non-melanoma skin cancer with only nine clinically felt to be a seborrhoeic keratosis.
  • These lesions may represent malignant transformation within the seborrhoeic keratosis.
  • Seven were diagnosed clinically as a skin malignancy, whereas three were thought to be solar keratoses.
  • Clinically, the remaining two were seborrhoeic keratoses.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Female. Head. Humans. Male. Medical Records. Middle Aged. Precancerous Conditions. Queensland / epidemiology. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637805.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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12. Kessler GM, Ackerman AB: Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective. Am J Dermatopathol; 2006 Dec;28(6):537-45
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  • [Title] Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective.
  • Squamous-cell carcinoma is the most common of all cancers and it develops in diverse organs of the body, among those being the skin, lung, gastrointestinal tract, and genitourinary tract, the latter including the cervix.
  • Unfortunately, no unanimity exists for naming very superficial squamous-cell carcinoma; it has not been designated in consistent fashion in a single organ, let alone in all of them, thereby resulting in confusion, not only in regard to terminology per se, but concerning matters conceptual, not the least of those being what appellation to apply to that condition when it is encountered histopathologically.
  • This vexing situation is illustrated graphically in the skin by diagnoses for very superficial squamous-cell carcinoma as disparate as solar keratosis (actinic keratosis, senile keratosis), arsenical keratosis, radiation keratosis, Bowen disease, bowenoid papulosis, squamous-cell carcinoma in situ, as well as variations on the theme of "keratinocytic intraepidermal neoplasia" and "dysplasia," and in the cervix by squamous-cell carcinoma in situ, leukoplakia, cervical intraepithelial neoplasia I-III, as well as variations on the theme of "squamous dysplasia ()."
  • There is a need urgently for a single term for very superficial squamous-cell carcinoma in every organ of the body in which it develops, to wit, one that conveys diagnosis in such logical, lucid, comprehensible fashion that it is understandable, readily and immediately, to clinicians.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Skin Neoplasms / classification. Uterine Cervical Neoplasms / classification

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  • (PMID = 17122500.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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13. Zaballos P, Blazquez S, Puig S, Salsench E, Rodero J, Vives JM, Malvehy J: Dermoscopic pattern of intermediate stage in seborrhoeic keratosis regressing to lichenoid keratosis: report of 24 cases. Br J Dermatol; 2007 Aug;157(2):266-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic pattern of intermediate stage in seborrhoeic keratosis regressing to lichenoid keratosis: report of 24 cases.
  • BACKGROUND: Lichenoid keratosis (LK) is a well-described entity which has been proposed to represent an immunological or regressive response to pre-existing epidermal lesions such as solar lentigines or seborrhoeic keratoses.
  • OBJECTIVES: To evaluate the dermoscopic criteria of a series of cases of LK with remaining areas of seborrhoeic keratosis which were both dermoscopically and histologically diagnosed.
  • METHODS: Pigmented lesions with dermoscopic areas of seborrhoeic keratosis and LK in the same tumour were consecutively diagnosed and prospectively included in the study.
  • All pigmented lesions were examined and registered using DermLite Foto equipment (3Gen, LLC, Dana Point, CA, U.S.A.
  • ), at 10-fold magnification, at the Dermatology Department of Hospital de Sant Pau i Santa Tecla (Tarragona, Spain), between 1 January 2003 and 31 December 2005.
  • RESULTS: In total, 24 cases of lesions with dermoscopic areas of seborrhoeic keratosis and LK were collected.
  • In four lesions (17%), the clinical differential diagnosis without dermoscopy included malignant melanoma and in seven lesions (29%), basal cell carcinoma.
  • The diagnosis of LK was clinically considered without dermoscopy in only six cases (25%).
  • [MeSH-major] Keratosis / diagnosis. Lichenoid Eruptions / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Dermoscopy. Diagnosis, Differential. Disease Progression. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / pathology. Male. Melanoma / diagnosis. Middle Aged. Prospective Studies. Skin Neoplasms / diagnosis

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  • (PMID = 17553042.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Gulias-Cañizo R, Aranda-Rábago J, Rodríguez-Reyes AA: [Seborrheic keratosis of conjunctiva: a case report]. Arch Soc Esp Oftalmol; 2006 Apr;81(4):217-9
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  • [Title] [Seborrheic keratosis of conjunctiva: a case report].
  • [Transliterated title] Queratosis seborreica de la conjuntiva: informe de un caso.
  • CASE REPORT: Pigmented conjunctival lesions are a diagnostic challenge for the clinician.
  • A 37-year-old man presented with a pigmented mass involving the conjunctiva of his right eye.
  • Clinically, a diagnosis of malignant melanoma was made and a wide excision of the tumor was performed.
  • The histopathologic diagnosis was seborrheic keratosis.
  • DISCUSSION: Seborrheic keratosis is a benign lesion which occurs on the eyelids and face of middle-aged and elderly individuals.
  • Seborrheic keratosis should be considered in the differential diagnosis of conjunctival pigmented lesions.
  • [MeSH-major] Conjunctival Diseases / pathology. Keratosis, Seborrheic / pathology

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  • (PMID = 16688646.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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15. Mabuchi T, Akasaka E, Kondoh A, Umezawa Y, Matsuyama T, Ozawa A: Seborrheic keratosis that follows Blaschko's lines. J Dermatol; 2008 May;35(5):301-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis that follows Blaschko's lines.
  • A 66-year-old Japanese man had skin lesions on the left side of his trunk and the left upper extremity for approximately 10 years.
  • Clinical and histopathological findings led to a diagnosis of seborrheic keratosis that followed Blaschko's lines.
  • Our case supports the hypothesis that seborrheic keratosis can be associated with genetic mosaicism.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Skin / pathology

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  • (PMID = 18477232.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Mitsuhashi Y, Kawaguchi M, Hozumi Y, Kondo S: Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis. J Dermatol; 2005 Jun;32(6):420-3
Hazardous Substances Data Bank. CHOLECALCIFEROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis.
  • Senile wart or seborrheic keratosis is a benign tumor which occurs mainly in the elderly.
  • We treated senile warts with topical vitamin D3 ointments (tacalcitol, calcipotriol or maxacalcitol).
  • An organ culture experiment using senile wart as a material with several concentrations of tacalcitol revealed that tacalcitol induced apoptosis in the tissue.
  • Vitamin D3 may affect senile warts by inducing apoptosis.
  • Clearance of senile warts, especially on exposed areas without pain, may improve the quality of life (QOL) of the elderly.
  • [MeSH-major] Cholecalciferol / therapeutic use. Keratosis, Seborrheic / drug therapy. Keratosis, Seborrheic / pathology
  • [MeSH-minor] Administration, Topical. Adult. Age Factors. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies. Severity of Illness Index. Treatment Outcome

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  • (PMID = 16043912.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1C6V77QF41 / Cholecalciferol
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17. de Giorgi V, Massi D, Salvini C, Mannone F, Carli P: Pigmented seborrheic keratoses of the vulva clinically mimicking a malignant melanoma: a clinical, dermoscopic-pathologic case study. Clin Exp Dermatol; 2005 Jan;30(1):17-9
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  • [Title] Pigmented seborrheic keratoses of the vulva clinically mimicking a malignant melanoma: a clinical, dermoscopic-pathologic case study.
  • The diagnosis of seborrheic keratosis is, in general, a clinical one, but in some cases, the differential diagnosis between pigmented seborrheic keratosis and malignant melanoma is difficult.
  • Dermoscopy may improve the early diagnosis of vulvar melanoma and thus play a role in the preoperative classification of pigmented lesions at this particular site.
  • We report the first case of a pigmented seborrheic keratosis of the vulva clinically mimicking a malignant melanoma, whose dermoscopic features have been investigated together with their pathologic correlates.
  • Dermoscopy is therefore a useful method for the differential diagnosis of pigmented lesions even in the vulva.
  • [MeSH-major] Dermoscopy / standards. Keratosis, Seborrheic / pathology. Melanoma / pathology. Vulvar Diseases / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged. Dermatology / methods. Diagnosis, Differential. Female. Humans

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  • (PMID = 15663494.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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18. Tsai TM, Wu YH, Yang KC, Yang CY, Tsai TH, Chan JY: Sebaceous carcinoma associated with seborrheic keratosis. J Cutan Med Surg; 2010 Sep-Oct;14(5):240-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous carcinoma associated with seborrheic keratosis.
  • BACKGROUND: The association of a seborrheic keratosis with other common cutaneous neoplasms such as basal cell carcinoma and Bowen disease has been reported, but the association between a seborrheic keratotis and a malignant neoplasm with sebaceous differentiation is very unusual.
  • OBJECTIVE: We present a case of two contiguous neoplasms, a seborrheic keratosis and a sebaceous carcinoma, and discuss the possibility of malignant change in a seborrheic keratosis as an explanation for the findings.
  • METHODS AND RESULTS: A 57-year-old man presented with an asymptomatic tumor on the skin of his abdomen that was composed of two separate but contiguous lesions.
  • Histopathologic examination revealed that the plaque was composed of two different adjacent tumors, including a central portion showing findings consistent with a sebaceous carcinoma and a peripheral part showing a seborrheic keratosis.
  • CONCLUSION: Although the association is likely to be a coincidence and probably represents a collision tumor, the possibility that the sebaceous carcinoma represents malignant degeneration of the seborrheic keratosis cannot be entirely excluded.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20868621.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Halleck P, Loddenkemper C, Hummel M, Scherer H, Haisch A: [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description]. HNO; 2009 May;57(5):480-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description].
  • [Transliterated title] Hyperkeratotische invertierte seborrhoische Keratose des äusseren Gehörgangs : Eine Erstbeschreibung.
  • Seborrheic keratosis is one of the most common benign neoplasms seen at the trunk, extremities, head and neck of older individuals which rarely occurs in the auditory canal.
  • Even rarer is the occurrence of an inverted or hyperkeratotic variant in this localization.
  • We present the clinical picture of a 74-year-old man with a recurrent hyperkeratotic, partially inverted seborrheic keratosis of the right external auditory canal.
  • This disease is sometimes difficult to diagnose, particulary to mark down malignant lesions.
  • An uncritical diagnosis must be avoided, since these lesions and especially the irritated subtype might be falsely assessed as basal cell carcinomas which they may resemble histologically.
  • [MeSH-major] Ear Diseases / diagnosis. Ear, External / pathology. Keratosis, Seborrheic / diagnosis

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  • [Cites] Otolaryngol Head Neck Surg. 1987 Feb;96(2):198-201 [2960940.001]
  • [Cites] J Korean Med Sci. 2001 Oct;16(5):619-22 [11641533.001]
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  • [Cites] J Dermatol Sci. 1992 Nov;4(3):166-71 [1337468.001]
  • (PMID = 17468841.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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20. Wu YH, Hsiao PF, Lin YC: Verruciform xanthoma-like phenomenon in seborrheic keratosis. J Cutan Pathol; 2006 May;33(5):373-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Verruciform xanthoma-like phenomenon in seborrheic keratosis.
  • We report a 72-year-old man who had an asymptomatic 1-cm black nodule on his abdomen.
  • Histopathology showed a typical acanthotic type of seborrheic keratosis characterized by basaloid keratinocyte proliferation and pseudohorn cysts.
  • The presence of verruciform xanthomatous change in seborrheic keratosis provides further evidence that verruciform xanthoma may be a reactive phenomenon occurring in common skin disorders.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Xanthomatosis / pathology

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  • (PMID = 16640546.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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21. Requena L, Kutzner H: Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants. J Cutan Pathol; 2006 Sep;33 Suppl 2:42-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants.
  • AIMS: Seborrheic keratoses are the most common benign cutaneous neoplasms in adult and middle-age patients.
  • There are six distinctive histopathologic variants of seborrheic keratosis, namely, acanthotic or solid, reticulated or adenoid, hyperkeratotic or papillomatous, clonal or nested, irritated and inflamed.
  • METHODS: We report two additional histopathologic variants of seborrheic keratosis.
  • RESULTS: One lesion showed abundant intercellular mucin, closely resembling to adamantinoma, and therefore was named adamantinoid seborrheic keratosis.
  • DISCUSSION: To our knowledge, these two histopathologic variants of seborrheic keratosis have been not previously described in the literature.
  • [MeSH-major] Adamantinoma / pathology. Keratinocytes / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972954.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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22. Pastar Z, Lipozencić J, Rados J, Stajminger G: Regressing seborrheic keratosis - clinically and dermoscopically mimicking a regressing melanoma. Acta Dermatovenerol Croat; 2007;15(1):24-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regressing seborrheic keratosis - clinically and dermoscopically mimicking a regressing melanoma.
  • The diagnosis of seborrheic keratosis is a clinical diagnosis.
  • In a certain percentage of cases, differential diagnosis between seborrheic keratosis and malignant melanoma is difficult.
  • We describe a case of regressing seborrheic keratosis simulating malignant melanoma.
  • Clinical, dermoscopic and histopathologic examinations were performed for the occurrence of an asymmetric, irregularly demarcated, irregularly pigmented lesion measuring 1.3 x 1.5 cm on the right part of the abdomen in a 76-year-old male Caucasian.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Dermoscopy. Diagnosis, Differential. Humans. Male

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  • (PMID = 17433176.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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23. Bruecks AK, Kalia S, Trotter MJ: Overexpression of p27KIP1 in seborrheic keratosis. J Cutan Med Surg; 2007 Sep-Oct;11(5):174-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of p27KIP1 in seborrheic keratosis.
  • BACKGROUND: The pathogenesis of seborrheic keratosis (SK) is not well understood.
  • SKs are slow growing, but the details of cell cycle control in these lesions are not known.
  • [MeSH-major] Intracellular Signaling Peptides and Proteins / metabolism. Keratinocytes / metabolism. Keratosis, Seborrheic / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Proliferation. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Cyclin-Dependent Kinase Inhibitor p27. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Middle Aged. Skin / anatomy & histology. Skin / metabolism

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 17942027.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / CDKN1B protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Intracellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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24. Büyüklü F, Aydin H, Tarhan E, Ada S, Cakmak O: Seborrheic keratosis of the nasal vestibule. Kulak Burun Bogaz Ihtis Derg; 2007;17(5):298-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis of the nasal vestibule.
  • Seborrheic keratosis is a common hyperkeratotic lesion of the epidermis, that usually occurs in the trunk and less frequently in the extremities, face, and the scalp.
  • An 80-year-old woman presented with a long-standing, slowly growing, firm, red-brown polypoid mass, 0.5 cm in size, located at the skin-mucosa interface of the right nasal vestibule.
  • The lesion was excised under local anesthesia and histopathologic examination showed seborrheic keratosis that mimicked squamous cell carcinoma.
  • [MeSH-major] Keratosis, Seborrheic / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 18187992.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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25. Braga JC, Scope A, Klaz I, Mecca P, Spencer P, Marghoob AA: Melanoma mimicking seborrheic keratosis: an error of perception precluding correct dermoscopic diagnosis. J Am Acad Dermatol; 2008 May;58(5):875-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma mimicking seborrheic keratosis: an error of perception precluding correct dermoscopic diagnosis.
  • Seborrheic keratosis is a common skin lesion that can usually be recognized either clinically or dermoscopically.
  • However, melanomas mimicking seborrheic keratoses, as well as melanomas arising in association with seborrheic keratoses, have been described.
  • We report the case of a patient with a lesion that initially revealed "classic" dermoscopic features of a seborrheic keratosis.
  • However, during follow-up, changes in color developed within the center of the lesion that led the clinician to the correct diagnosis of melanoma.
  • Dermatologists should be cognizant of "errors in perception"; we suggest that a final dermoscopic judgment of a seborrheic keratosis be rendered by combining the gestalt diagnosis of the overall pattern, with deliberate dermoscopic analysis of all quadrants of the lesion.
  • [MeSH-major] Diagnostic Errors. Head and Neck Neoplasms / diagnosis. Keratosis, Seborrheic / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis


26. Sawada Y, Yoshiki R, Kawakami C, Nakamura M, Tokura Y: [Seborrheic keratosis on the umbilicus: case report and review of Japanese literature]. J UOEH; 2009 Mar 1;31(1):51-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Seborrheic keratosis on the umbilicus: case report and review of Japanese literature].
  • A 78-year-old man was seen for a tumor on his umbilicus.
  • The excised tumor showed the acanthotic type of seborrheic keratosis.
  • Six cases of seborrheic keratosis arising on the umbilicus have been reported.
  • Our case is the first report of an acanthotic type of seborrheic keratosis on the umbilicus.
  • Seborrheic keratosis is one of the common skin tumors, but we hesitated in this diagnosis because of its abnormal location.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Umbilicus

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  • (PMID = 19297955.001).
  • [ISSN] 0387-821X
  • [Journal-full-title] Journal of UOEH
  • [ISO-abbreviation] J. UOEH
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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27. Zaballos P, Salsench E, Serrano P, Cuellar F, Puig S, Malvehy J: Studying regression of seborrheic keratosis in lichenoid keratosis with sequential dermoscopy imaging. Dermatology; 2010;220(2):103-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Studying regression of seborrheic keratosis in lichenoid keratosis with sequential dermoscopy imaging.
  • BACKGROUND: Lichenoid keratosis (LK) is a well-described entity that has been proposed to represent a regressive response to a pre-existent epidermal lesion.
  • AIMS: To evaluate the natural evolution of a series of cases showing the intermediate stage of the regression of seborrheic keratosis in LK using sequential dermoscopy imaging over time.
  • MATERIAL AND METHODS: A series of lesions with dermoscopic areas of seborrheic keratosis and LK in the same tumor were consecutively collected for over 3 years at the Dermatology Department of the Hospital de Sant Pau i Santa Tecla, Tarragona, Spain.
  • In 11 cases (50%), the seborrheic keratosis part disappeared completely, and in another 5 cases (22.7%), seborrheic keratosis comprised only 10% of the remaining area.
  • CONCLUSIONS: These dermoscopic study findings support the proposal that LK represents a regressive response to a pre-existent epidermal lesion, in this case seborrheic keratosis.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / diagnosis. Lichen Planus / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology. Skin Pigmentation

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  • (PMID = 19996577.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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28. Brodsky J: Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea. Curr Opin Otolaryngol Head Neck Surg; 2009 Aug;17(4):315-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea.
  • RECENT FINDINGS: Actinic keratosis can now be treated with photodynamic therapy or with many topical agents, as alternatives to traditional surgical techniques.
  • Seborrheic keratosis, as well as actinic keratosis and rosacea, are now often treated with laser therapy.
  • [MeSH-major] Facial Dermatoses / therapy. Keratosis, Actinic / therapy. Keratosis, Seborrheic / therapy. Rosacea / therapy

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  • (PMID = 19465852.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dermatologic Agents
  • [Number-of-references] 46
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29. Neuhaus IM, LeBoit PE, McCalmont TM: Seborrheic keratosis with basal clear cells: a distinctive microscopic mimic of melanoma in situ. J Am Acad Dermatol; 2006 Jan;54(1):132-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis with basal clear cells: a distinctive microscopic mimic of melanoma in situ.
  • BACKGROUND: We observed seborrheic keratoses with many basilar clear cells, creating a microscopic pattern that mimicked a seborrheic keratosis involved by melanoma in situ.
  • OBJECTIVE: We sought to report a series of these seborrheic keratoses and the immunohistochemical stains used to reach a proper diagnosis.
  • METHODS: We reviewed 9 cases of seborrheic keratosis that had a distinctive pattern of basal clear cells with ample cytoplasm.
  • RESULTS: The basal clear cells failed to react with Melan-A and S-100 protein antisera.
  • CONCLUSIONS: We describe a previously uncharacterized pattern of seborrheic keratosis that can microscopically mimic melanoma in situ.
  • Careful conventional microscopy coupled with a panel of immunostains can allow the proper diagnosis to be reached.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies. Antigens, Neoplasm. Diagnosis, Differential. Female. Humans. Immune Sera. Immunoenzyme Techniques. Keratins / immunology. MART-1 Antigen. Male. Middle Aged. Neoplasm Proteins / immunology. Retrospective Studies. S100 Proteins / immunology. Staining and Labeling

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  • [CommentIn] J Cutan Pathol. 2017 Jun;44(6):600-602 [28401581.001]
  • (PMID = 16384768.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Neoplasm; 0 / Immune Sera; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
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30. Hafner C, López-Knowles E, Luis NM, Toll A, Baselga E, Fernández-Casado A, Hernández S, Ribé A, Mentzel T, Stoehr R, Hofstaedter F, Landthaler M, Vogt T, Pujol RM, Hartmann A, Real FX: Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc Natl Acad Sci U S A; 2007 Aug 14;104(33):13450-4
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.
  • Activating FGF receptor 3 (FGFR3) mutations are common in benign skin lesions, either as embryonic mutations in epidermal nevi (EN) or as somatic mutations in seborrheic keratoses (SK).
  • [MeSH-major] Keratosis, Seborrheic / genetics. Mutation. Nevus / genetics. Phosphatidylinositol 3-Kinases / antagonists & inhibitors

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  • (PMID = 17673550.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
  • [Other-IDs] NLM/ PMC1948900
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31. Hafner C, Vogt T: Seborrheic keratosis. J Dtsch Dermatol Ges; 2008 Aug;6(8):664-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis.
  • Seborrheic keratosis is one of the most common skin tumors.
  • Despite its frequency, many aspects of seborrheic keratosis remain elusive.
  • In the last years new molecular genetic insights into seborrheic keratoses have been gained.
  • The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized.
  • [MeSH-major] Clinical Trials as Topic / trends. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / therapy

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  • (PMID = 18801147.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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32. Hoshina D, Akiyama M, Hata H, Aoyagi S, Sato-Matsumura KC, Shimizu H: Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. Clin Exp Dermatol; 2007 Jan;32(1):54-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis.
  • An association between seborrhoeic keratosis (SK) and malignant tumours is considered to be rare.
  • We observed a case of eccrine porocarcinoma and Bowen's disease (BD) occurring synchronously, forming one lesion in a SK on the abdomen.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma / pathology. Eccrine Glands. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2008 May;33(3):350-1 [18261140.001]
  • (PMID = 17004985.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Liu H, Chen S, Zhang F, Shi B, Shi Z, Zhang D, Yu M, Tian H, Yang B: Seborrheic keratosis or verruca plana? A pilot study with confocal laser scanning microscopy. Skin Res Technol; 2010 Nov;16(4):408-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrheic keratosis or verruca plana? A pilot study with confocal laser scanning microscopy.
  • BACKGROUND: Differentiation of some seborrheic keratosis (SK) and verruca plana (VP) lesions is a challenge.
  • Confocal laser scanning microscopy (CLSM) has been proved to be useful in the diagnosis of skin diseases; however, to date, there is no report on the differential study of the two diseases with CLSM.
  • All the cases with lesions suggestive of SK or VP were advised to undergo imaging with CLSM, and if CLSM imaging reflected discordantly with the clinical diagnosis, a biopsy was suggested for the exact lesion imaged.
  • CONCLUSION: CLSM proved to be valuable in the differential diagnosis of SK and VP.
  • [MeSH-major] Dermoscopy / methods. Keratosis, Seborrheic / pathology. Microscopy, Confocal / methods. Warts / pathology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Pilot Projects. Prospective Studies. Skin / pathology

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 21039905.001).
  • [ISSN] 1600-0846
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Denmark
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34. Borenstein M, Mirzabeigi M, Vincek V: Pityrosporum and seborrheic keratosis: an association. Dermatol Online J; 2005;11(2):3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pityrosporum and seborrheic keratosis: an association.
  • Seborrheic keratoses (SK) are one of the most common benign tumors of the skin.
  • Pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, however, its potential role in association with SK's has not been evaluated as evidenced by the fact that there are no publications in the English-language literature regarding this issue.
  • We found that in a majority of the SK studied Pityrosporum was present, which was significantly different from controls (verruca vulgaris and basal cell carcinoma).
  • [MeSH-major] Dermatomycoses / complications. Keratosis, Seborrheic / etiology. Keratosis, Seborrheic / microbiology. Malassezia / isolation & purification

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  • (PMID = 16150211.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Oyama N, Kaneko F: Trichilemmal carcinoma arising in seborrheic keratosis: a case report and published work review. J Dermatol; 2008 Dec;35(12):782-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trichilemmal carcinoma arising in seborrheic keratosis: a case report and published work review.
  • The secondary skin malignancies arising in seborrheic keratosis (SK) are uncommon, and the causal association between the pre-existing lesion and subsequent malignant transformation remains uncertain.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Hair Diseases / pathology. Keratosis, Seborrheic / complications. Skin Neoplasms / pathology

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  • (PMID = 19239559.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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36. Kopf AW, Rabinovitz H, Marghoob A, Braun RP, Wang S, Oliviero M, Polsky D: "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses. J Am Acad Dermatol; 2006 Dec;55(6):1089-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses.
  • "Fat fingers" are thick digitate linear, curvilinear, branched, or oval/circular dermoscopic structures typically seen in seborrheic keratoses where they represent the gyri of their cerebriform surfaces.
  • Their recognition is very useful in the diagnosis of these lesions, especially when the classic features (eg, milia, comedo-like openings) are absent.
  • Histologically and by confocal microscopy the "fat finger" gyri are accentuated by pigmented keratin filling the sulci.
  • "Fat fingers" must be differentiated from other linear structures such as "network-like structures"; branched streaks; network; globules; pigmented ovoid-nests; and streaks/pseudopods seen in different melanocytic and non-melanocytic lesions.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / diagnosis

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  • (PMID = 17097405.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Hafner C, Landthaler M, Mentzel T, Vogt T: FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. Br J Dermatol; 2010 Mar;162(3):508-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra.
  • BACKGROUND: Stucco keratosis (STK) and dermatosis papulosa nigra (DPN) are referred to as variants of seborrhoeic keratosis.
  • OBJECTIVES: Because FGFR3 and PIK3CA mutations have been reported to be involved in the pathogenesis of seborrhoeic keratosis, we analysed whether these mutations are also present in STK and DPN.
  • The molecular genetic findings furthermore support the concept that both skin lesions are specific variants of seborrhoeic keratosis, sharing a common genetic background.
  • [MeSH-major] Keratosis, Seborrheic / genetics. Phosphatidylinositol 3-Kinases / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics

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  • (PMID = 19845664.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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38. Shamsadini S, Wadji MB, Shamsadini A: Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign). Dermatol Online J; 2006;12(6):27
MedlinePlus Health Information. consumer health - Breast Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign).
  • Paget disease of the breast, most often occurs in middle-aged women.
  • We report a patient with Paget disease of the nipple and intraductal carcinoma who presented with ipsilateral, eruptive grouped seborrheic keratoses of the areola and nipple of the breast.
  • [MeSH-major] Breast Diseases / etiology. Breast Neoplasms / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Keratosis, Seborrheic / etiology. Paget's Disease, Mammary / diagnosis. Paraneoplastic Syndromes / etiology

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  • (PMID = 17083907.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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39. Askari SK, Schram SE, Wenner RA, Bowers S, Liu A, Bangerter AK, Warshaw EM: Evaluation of prospectively collected presenting signs/symptoms of biopsy-proven melanoma, basal cell carcinoma, squamous cell carcinoma, and seborrheic keratosis in an elderly male population. J Am Acad Dermatol; 2007 May;56(5):739-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of prospectively collected presenting signs/symptoms of biopsy-proven melanoma, basal cell carcinoma, squamous cell carcinoma, and seborrheic keratosis in an elderly male population.
  • BACKGROUND: Presenting signs/symptoms of skin cancer may aid in earlier detection and diagnosis.
  • OBJECTIVE: We sought to compare prospectively collected, presenting signs/symptoms of malignant melanoma (MM), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and seborrheic keratosis (SK).
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Keratosis, Seborrheic / diagnosis. Melanoma / diagnosis. Skin Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Humans. Male. Middle Aged. Prospective Studies. Skin Neoplasms / diagnosis


40. Kim JY, Kim HS, Lee S, Park JH: The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin. Pathol Res Pract; 2010 May 15;206(5):295-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin.
  • We performed an immunohistochemical examination of GLTSCR2 expression in samples of seborrheic keratosis (SK, n=69), a common benign skin tumor, and normal skin (n=23), and assessed the relationship between GLTSCR2 expression and the patients' clinicopathologic factors.
  • Our results showed that GLTSCR2 expression in SK was significantly lower than in normal skin (p<0.001), and this decreased expression of GLTSCR2 was associated with patient age (p=0.045).
  • [MeSH-major] Keratosis, Seborrheic / metabolism. Skin / metabolism. Tumor Suppressor Proteins / metabolism

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  • [Copyright] (c) 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20185249.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / GLTSCR2 protein, human; 0 / Tumor Suppressor Proteins
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41. Ko CJ, Kim J, Phan J, Binder SW: Bcl-2-positive epidermal dendritic cells in inverted follicular keratoses but not squamous cell carcinomas or seborrheic keratoses. J Cutan Pathol; 2006 Jul;33(7):498-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bcl-2-positive epidermal dendritic cells in inverted follicular keratoses but not squamous cell carcinomas or seborrheic keratoses.
  • AIM: In our previous research, bcl-2-positive dendritic cells were seen in increased numbers in suprabasal areas of inverted follicular keratoses (IFKs) compared to seborrheic keratoses (SKs).
  • The purpose of this study was twofold; firstly, to support that these dendritic cells are Langerhans cells and secondly, to contrast the epidermal dendritic cells in IFKs, squamous cell carcinomas (SCCs), and SKs.
  • SCCs showed bcl-2-positive cells only within the basal layer of the normal epidermis flanking the carcinomas.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Darier Disease / metabolism. Keratosis, Seborrheic / metabolism. Langerhans Cells / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Antigens, CD1 / metabolism. Biomarkers, Tumor / metabolism. Cell Count. Humans. Immunohistochemistry

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  • (PMID = 16872473.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD1; 0 / Biomarkers, Tumor; 0 / CD1a antigen; 0 / Proto-Oncogene Proteins c-bcl-2
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42. Goetze S, Ziemer M, Kaatz M, Lipman RD, Elsner P: Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study. Dermatol Surg; 2006 May;32(5):661-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study.
  • OBJECTIVE: To evaluate the wound-healing activity of a commercially available hydrocolloid wound dressing (Avery H2460, Avery Dennison, Turnhout, Belgium) in comparison with a control treatment (Fucidine cream with Cutiplast sterile dressing) in superficial wounds after surgical removal of seborrheic keratoses.
  • Sixteen patients between 18 and 80 years of age with seborrheic keratoses were enrolled.
  • [MeSH-major] Bandages, Hydrocolloid. Keratosis, Seborrheic / surgery

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  • (PMID = 16706761.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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43. Hida Y, Kubo Y, Arase S: Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours. Br J Dermatol; 2009 Jun;160(6):1258-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We investigated the activation of FGFR3 and OIS by mutation and immunohistochemical analysis in skin tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
  • RESULTS: Activated point mutations of FGFR3 were identified in four of 22 cases (18%) of seborrhoeic keratosis, but no mutation was detected in the other skin tumours.
  • Twenty-seven of 31 cases (87%) of seborrhoeic keratosis showed moderately to strongly positive expression of the FGFR3 protein, but almost all the other skin tumours were negative.
  • On the other hand, almost all the seborrhoeic keratoses showed negative immunoreactivity for antiphoshohistone H2AX (gamma-H2AX) as a marker of OIS, but 17 of 22 cases (77%) of AK were moderately to strongly positive.
  • Immunoreactivity for gamma-H2AX was significantly greater in AK than in seborrhoeic keratosis, BD, BCC and SCC.
  • CONCLUSIONS: The activation of FGFR3 might be a common feature in the tumorigenesis in seborrhoeic keratosis, although the activation does not induce a typical oncogenic signal in keratinocytes.
  • [MeSH-minor] Bowen's Disease / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Squamous Cell / genetics. Chi-Square Distribution. Humans. Keratosis, Actinic / genetics. Keratosis, Seborrheic / genetics. Point Mutation / genetics. Transcriptional Activation

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  • (PMID = 19298285.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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44. Bon-Mardion M, Poulalhon N, Balme B, Thomas L: Ungual seborrheic keratosis. J Eur Acad Dermatol Venereol; 2010 Sep;24(9):1102-4
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  • [Title] Ungual seborrheic keratosis.
  • BACKGROUND/OBJECTIVES: Seborrheic keratoses are ubiquitous benign epithelial skin tumours.
  • We report herein the case of a seborrheic keratosis of the nail bed with typical histological features.
  • METHODS/RESULTS: A 58-year-old man presented with a 1-year-history of longitudinal leukoxanthonychia of the right hallux.
  • The diagnosis of typical seborrheic keratosis of the nail bed was made on histological examination.
  • CONCLUSION: To our knowledge, this is the first report of a typical, histologically documented seborrheic keratosis of the nail bed.
  • Therefore, this condition should be added to the differential diagnosis of acquired longitudinal leukoxanthonychia.
  • However, surgical treatment remains necessary to rule out other causes, including squamous cell carcinoma.
  • [MeSH-major] Keratosis, Seborrheic / diagnosis. Nail Diseases / diagnosis

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  • (PMID = 20180892.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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45. Lim C: Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions. Australas J Dermatol; 2006 May;47(2):109-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions.
  • Seborrhoeic keratoses are benign epidermal neoplasms that are rarely associated with other skin lesions especially malignancies.
  • In this study, the aim was to assess the incidence of associated lesions occurring either adjacent to or contiguous with a seborrhoeic keratosis.
  • In total, 639 consecutive histologically diagnosed seborrhoeic keratoses were identified, of which 85 (9%) were found to be associated with other lesions.
  • Of these associated lesions, 44 (7%) were malignant, with four of these found to be arising within the seborrhoeic keratosis.
  • The average age was 74 years (range 33-98 years).
  • Seborrhoeic keratoses associated with other lesions were found most commonly on the head and neck.
  • The incidence of associated lesions, in particular malignancy arising within seborrhoeic keratoses may be higher than previously thought.
  • This may be an incidental phenomenon, or seborrhoeic keratosis could represent a precursor lesion.
  • Therefore, seborrhoeic keratoses that have undergone recent clinical change should be considered for biopsy and histological examination.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Extremities. Head. Humans. Medical Records. Melanoma / epidemiology. Melanoma / etiology. Melanoma / pathology. Middle Aged. Neck. New South Wales / epidemiology. Precancerous Conditions. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637806.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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46. Yanagi T, Shibaki A, Tsuji-Abe Y, Yokota K, Shimizu H: Epidermodysplasia verruciformis and generalized verrucosis: the same disease? Clin Exp Dermatol; 2006 May;31(3):390-3
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  • [Title] Epidermodysplasia verruciformis and generalized verrucosis: the same disease?
  • We report a patient with epidermodysplasia verruciformis (EV) who had severe generalized verrucous skin lesions for 50 years without any immunological abnormality.
  • Microscopic examination showed two histopathological features, including seborrhoeic keratosis and common warts.
  • The detected human papilloma virus (HPV) types were found to be HPV 3, 50, 5, and 76, using a degenerate PCR method.
  • [MeSH-minor] Antiviral Agents / therapeutic use. Calcitriol / analogs & derivatives. Calcitriol / therapeutic use. DNA, Viral / analysis. Etretinate / therapeutic use. Humans. Immunocompetence. Male. Middle Aged. Polymerase Chain Reaction. Warts / classification. Warts / drug therapy. Warts / pathology

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  • (PMID = 16681585.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral; 103909-75-7 / maxacalcitol; 65M2UDR9AG / Etretinate; FXC9231JVH / Calcitriol
  • [Number-of-references] 8
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47. Puizina-Ivić N, Sapunar D, Marasović D, Mirić L: An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis. Coll Antropol; 2008 Oct;32 Suppl 2:61-5
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  • [Title] An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis.
  • The Bcl-2 protein has been shown to suppress cell death and protects cell against apoptosis induced by different death-inducing signals.
  • In this study the authors have analyzed imunohistochemically the expression of Bcl-2 protein in the histopathological variants of the most common malignant tumors of the skin--basal cell carcinoma (BCC) and squamous cell tumor (SCC), as well as in the precancerous lesion actinic keratosis (AK) and in benign tumor seborrheic keratosis (SK).
  • In cases of hypertrophic and atrophic variants of AK, Bcl-2 expression was confined to basal cell layer, as well as in one case of hypertrophic variant in suprabasal cells.
  • In morpheaform variant reduced amount of Bcl-2 expression indicated that this variant of BCC has increased cell proliferation, and in practice shows tendency for recurrence and difficulties to eradicate.
  • Bcl-2 expression supports the observation that tumor cells are derived from basal keratinocytes.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Keratosis, Actinic / metabolism. Keratosis, Seborrheic / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Skin Neoplasms / metabolism


48. Kullander J, Forslund O, Dillner J: Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev; 2009 Feb;18(2):472-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Staphylococcus aureus and squamous cell carcinoma of the skin.
  • Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought.
  • We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with biopsies from healthy skin of these 353 immunocompetent patients.
  • In a S. aureus-specific PCR, targeting the nuc gene, presence of S. aureus DNA was strongly associated with SCC (29.3% positive specimens; adjusted odds ratio, 6.23; 95% confidence interval, 3.10-12.53) compared with healthy skin (5.7% positive specimens).
  • There was also a tendency for association of S. aureus with actinic keratosis, but no association was found for basal cell carcinoma or seborrhoeic keratosis.
  • [MeSH-major] Carcinoma, Squamous Cell / microbiology. Staphylococcus aureus / isolation & purification
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / microbiology. Case-Control Studies. DNA, Bacterial / analysis. Female. Humans. Keratosis, Actinic / microbiology. Keratosis, Seborrheic / microbiology. Logistic Models. Male. Middle Aged. Polymerase Chain Reaction. Precancerous Conditions / microbiology

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  • (PMID = 19155437.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial
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49. Gunia S, Liebe D, Koch S: Loss of basal cell keratin 14 reflects increased risk of recurrence in surgically resected sinonasal inverted papilloma. J Clin Pathol; 2008 Jun;61(6):707-12
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  • [Title] Loss of basal cell keratin 14 reflects increased risk of recurrence in surgically resected sinonasal inverted papilloma.
  • AIMS: To evaluate selected markers in terms of their possible relation to the development of recurrence in microsurgically resected sinonasal inverted papilloma (SIP) in order to advance understanding of the mechanisms pathogenetically involved, and to identify novel biomarkers for individual risk assessment in SIP.
  • RESULTS: Increased proliferative activity (Ki67) and loss of basal cell keratin 14 (CK14) expression were related to the development of recurrence in microsurgically resected SIP.
  • CONCLUSION: These findings might advance understanding of the pathogenesis behind the development of recurrence in microsurgically resected SIP by focusing on so far neglected alterations of cell-matrix connections at the epithelial-stromal interface in SIP, and might hint at CK14 representing a possible novel biomarker for individual risk assessment in microsurgically resected SIP.
  • [MeSH-major] Biomarkers, Tumor / analysis. Keratin-14 / analysis. Ki-67 Antigen / analysis. Neoplasm Recurrence, Local / metabolism. Papilloma, Inverted / metabolism. Paranasal Sinus Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Cell Proliferation. Databases, Factual. Female. Humans. Male. Microsurgery. Middle Aged. Proportional Hazards Models. Retrospective Studies. Risk. Staining and Labeling. Statistics, Nonparametric

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  • (PMID = 18505889.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-14; 0 / Ki-67 Antigen
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50. Schulz H: [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?]. Hautarzt; 2010 Dec;61(12):1061-2
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  • [Title] [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?].
  • [Transliterated title] Pigmentierte Läsion der Schläfenregion. Melanozytärer Tumor, Basalzellkarzinom oder irritierte seborrhoische Keratose?
  • 33-year-old woman with a red-brown plaque on the temple.
  • Histopathological diagnosis revealed an irritated seborrheic keratosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Facial Neoplasms / diagnosis. Keratosis, Seborrheic / diagnosis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adult. Biopsy. Dermoscopy. Diagnosis, Differential. Female. Forehead. Humans. Skin / pathology

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  • [Cites] Dermatol Clin. 2001 Apr;19(2):347-57 [11556243.001]
  • [Cites] Arch Dermatol. 2002 Dec;138(12):1556-60 [12472342.001]
  • (PMID = 21069503.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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51. Choi HJ, Yun SK, Kim HU, Ihm CW: Squamous eddies in irritated seborrheic keratosis. Am J Dermatopathol; 2007 Feb;29(1):28-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous eddies in irritated seborrheic keratosis.
  • Seborrheic keratosis is related to the intraepidermal hair follicle in its morphogenesis.
  • Squamous eddies in irritated seborrheic keratosis (ISK) are known to develop by focal maturation of basaloid cells, but the significance of squamous eddies is not understood.
  • The purpose of this study was to elucidate the nature of squamous eddies in ISK.
  • Serial sections of paraffin blocks of 20 cases of ISK were examined.
  • In 13 cases, squamous eddies were connected to keratotic invaginations we thought to be follicular infundibula.
  • Eighteen of the 20 cases of ISK showed at least 1 of the morphological features of intraepidermal hair follicle structures.
  • We have found that the squamous eddies of ISK are anatomically related to acrotrichia.
  • [MeSH-major] Epithelial Cells / pathology. Keratosis, Seborrheic / pathology. Skin / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Hair Follicle / pathology. Humans. Male. Middle Aged

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  • [ErratumIn] Am J Dermatopathol. 2007 Apr;29(2):229. Choi, Hye-Ja [added]; Yun, Seok-Kweon [added]; Kim, Han-U K [added]
  • (PMID = 17284959.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Knopf A, Schneider J, Schipper J, Hoffmann TK, Bas M: [Sinonasal basaloid squamous cell carcinoma in biopsies of inverted papilloma]. HNO; 2008 Aug;56(8):808-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sinonasal basaloid squamous cell carcinoma in biopsies of inverted papilloma].
  • Basaloid squamous cell carcinoma (BSCC) is a rare tumor representing an aggressive variant of squamous cell carcinoma (SCC) and arising from a common precursor cell.
  • We report on an 83-year-old woman with BSCC after multiple resections of an inverted papilloma (IP) of the left sinonasal tract.
  • Because of the tumor's expansion, the patient's age, and comorbidity, surgery was not performed, but primary radiotherapy was initiated.
  • In any case, IP requires consequent endoscopic and, if necessary, radiological follow-up in order to detect recurrent disease or malignant transformation.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Squamous Cell / pathology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / pathology

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  • [Cites] Acta Otolaryngol. 1996 Sep;116(5):762-5 [8908257.001]
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  • (PMID = 17876561.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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53. Zaballos P, Llambrich A, Puig S, Malvehy J: Dermoscopy is useful for the recognition of benign-malignant compound tumours. Br J Dermatol; 2005 Sep;153(3):653-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In cases where a malignant neoplasm exists in association with a benign lesion it is important to make an accurate diagnosis in order to treat the lesions correctly.
  • Dermoscopy is an in vivo, noninvasive technique that improves the clinical accuracy in diagnosing melanoma and other pigmented skin lesions.
  • We describe the dermoscopic characteristics of various collision or compound tumours that were composed of benign and malignant neoplasms: two cases of seborrhoeic keratosis associated with basal cell carcinoma, two cases of melanocytic naevus and basal cell carcinoma and one case of dermatofibroma associated with basal cell carcinoma.
  • [MeSH-major] Dermoscopy. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Keratosis, Seborrheic / diagnosis. Male. Middle Aged. Nevus, Pigmented / diagnosis

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  • (PMID = 16120160.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 14
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54. Ozolek JA, Barnes EL, Hunt JL: Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study. Arch Pathol Lab Med; 2007 Apr;131(4):530-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study.
  • CONTEXT: The pathogenesis of respiratory epithelial adenomatoid hamartoma (REAH) and inverted papilloma (IP) is poorly understood, especially compared with sinonasal adenocarcinoma (SNAC).
  • One feature of malignant glandular lesions is loss of the basal/myoepithelial layer.
  • The immunophenotype of the basal/myoepithelial layer has not been fully examined in benign glandular lesions of the sinonasal tract.
  • OBJECTIVE: To examine benign and malignant glandular lesions in the sinonasal tract for the immunophenotype of basal/myoepithelial cells, proliferation index, and cytokeratin and intestinal differentiation profiles.
  • RESULTS: Basal/myoepithelial cells in CS and REAH were positive for p63 and 34betaE12 but negative for SMA, S100 protein, and calponin.
  • Inverted papilloma demonstrated broad areas staining for p63 and 34betaE12, with intermediate proliferative activity in these areas.
  • Sixty percent of morphologic ITACs expressed CDX-2.
  • CONCLUSIONS: Basal/myoepithelial cells in CS and REAH should be considered basal and not myoepithelial cells.
  • [MeSH-major] Adenocarcinoma / pathology. Hamartoma / pathology. Keratins / metabolism. Papilloma / pathology. Paranasal Sinus Neoplasms / pathology. Sinusitis / pathology
  • [MeSH-minor] Actins / metabolism. Biomarkers, Tumor / analysis. Calcium-Binding Proteins / metabolism. Cell Proliferation. Chronic Disease. Diagnosis, Differential. Epithelial Cells / pathology. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Immunophenotyping. Ki-67 Antigen / metabolism. Male. Membrane Proteins / metabolism. Microfilament Proteins / metabolism. Middle Aged. S100 Proteins / metabolism. Trans-Activators / metabolism

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  • (PMID = 17425380.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / S100 Proteins; 0 / Trans-Activators; 0 / calponin; 156560-97-3 / Cdx-2-3 protein; 68238-35-7 / Keratins
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55. Hafner C, Hartmann A, Real FX, Hofstaedter F, Landthaler M, Vogt T: Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses. J Invest Dermatol; 2007 Aug;127(8):1883-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses.
  • Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK).
  • [MeSH-major] Keratosis, Seborrheic / genetics. Mutation. Receptor, Fibroblast Growth Factor, Type 3 / metabolism

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  • (PMID = 17392824.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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56. Culbertson GR: 532-nm diode laser treatment of seborrheic keratoses with color enhancement. Dermatol Surg; 2008 Apr;34(4):525-8; discussion 528
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  • [Title] 532-nm diode laser treatment of seborrheic keratoses with color enhancement.
  • BACKGROUND: Seborrheic keratoses (SKs) are benign cutaneous tumors of the epidermis.
  • Hypopigmentation occurred in 6% of patients and was associated with old, chronic, or recalcitrant lesions.
  • [MeSH-major] Color Therapy. Keratosis, Seborrheic / therapy. Laser Therapy / methods. Lasers, Semiconductor

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  • (PMID = 18248487.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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57. Vasiljevic N, Hazard K, Dillner J, Forslund O: Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis. J Gen Virol; 2008 Oct;89(Pt 10):2467-74
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  • [Title] Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis.
  • Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin.
  • This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients by HPV type-specific real-time PCR assays.
  • [MeSH-major] Betapapillomavirus / classification. Betapapillomavirus / isolation & purification. Keratosis / virology. Papillomavirus Infections / epidemiology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / virology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / virology. Female. Humans. Keratosis, Seborrheic / epidemiology. Keratosis, Seborrheic / virology. Male. Molecular Sequence Data. Phylogeny. Polymerase Chain Reaction / methods. Prevalence. Sequence Analysis, DNA. Skin / virology. Skin Neoplasms / epidemiology. Skin Neoplasms / virology. Species Specificity. Viral Load

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  • (PMID = 18796715.001).
  • [ISSN] 0022-1317
  • [Journal-full-title] The Journal of general virology
  • [ISO-abbreviation] J. Gen. Virol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ EF422221/ EU410347/ EU410348/ EU410349
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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58. Mokhtari M, Mesbah A, Rajabi P, Rajabi MA, Chehrei A, Mougouei K: Determination of the relationship between Basal cell carcinoma and human papilloma virus, based on immunohistochemistry staining method. Indian J Dermatol; 2009 Jul;54(3):225-8

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  • [Title] Determination of the relationship between Basal cell carcinoma and human papilloma virus, based on immunohistochemistry staining method.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer among Caucasians, and in most cases, occurs in the sun-exposed areas.

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  • [Cites] Br J Dermatol. 2007 Dec;157 Suppl 2:47-51 [18067632.001]
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  • (PMID = 20161851.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2810686
  • [Keywords] NOTNLM ; Basal cell carcinoma / human papilloma virus / immunohistochemistry
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59. Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H, Takeuchi S, Tu YT, Moroi Y, Furue M: Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol; 2009 Feb;160(2):442-5
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  • BACKGROUND: The enzyme mammalian target of rapamycin (mTOR) integrates many different cellular signals to control cell growth and proliferation, protein synthesis and breakdown, and other processes.
  • To date, there has been no report on the expression of protein kinase B (AKT)/mTOR cell signalling in epidermal tumours.
  • METHODS: Immunohistological staining was performed with phosphorylated (p-) AKT, p-mTOR, p-4E-binding protein 1 (p-4EBP1), p-ribosomal protein S6 (p-S6), p-p70 ribosomal protein S6 kinase 1 (p-p70S6K1) and CDK2 in 15 cases each of seborrhoeic keratosis, actinic keratosis, keratoacanthoma and Bowen's disease (BD), and 25 cases of squamous cell carcinoma (SCC).
  • [MeSH-major] Bowen's Disease / metabolism. Carcinoma, Squamous Cell / metabolism. Cyclin-Dependent Kinase 2 / metabolism. Keratosis, Actinic / pathology. Sirolimus / pharmacology. Skin Neoplasms / metabolism


60. Suiqing C, Min Z, Lirong C: Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma. J Dermatol; 2005 May;32(5):354-60
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  • [Title] Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma.
  • In order to evaluate the possible effects of STAT3 phosphorylation and expression of E-cadherin on metastasis of some human epidermal non-melanoma cutaneous tumors, the expression of phosphorylated STAT3 (p-STAT3) and E-cadherin were analyzed by immunohistochemistry staining in formalin-fixed, paraffin-embedded tissue sections of human cutaneous squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and seborrhoeic keratosis (SK).
  • 3) E-cadherin was strongly expressed on the cell membranes of normal skin and SK, especially on basal cells.
  • E-cadherin was weakly expressed on cell membranes of SCC and BCC (p<0.001), whereas its expression was significantly lower in SCC than in BCC (p<0.05).
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic. Neoplasm Invasiveness / physiopathology. Skin Neoplasms / metabolism. Trans-Activators / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy, Needle. Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / secondary. Case-Control Studies. Female. Humans. Immunohistochemistry. Keratosis, Seborrheic / metabolism. Keratosis, Seborrheic / pathology. Male. Probability. Prognosis. Reference Values. STAT3 Transcription Factor. Sensitivity and Specificity. Tissue Culture Techniques

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  • (PMID = 16043897.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / Trans-Activators
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61. van der Kwast TH: How to combine the molecular profile with the clinicopathological profile of urothelial neoplastic lesions. Scand J Urol Nephrol Suppl; 2008 Sep;(218):175-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This article provides an overview of the more recent molecular-genetic findings in the field and critically appraises their relationship with each of the WHO 2004 disease categories.
  • Regarding urothelial papilloma, clinical and limited molecular-genetic data seem to suggest that they may not represent a precursor lesion for bladder cancer.
  • It is more likely that urothelial papilloma is a benign neoplasm sharing mutations in the fibroblast growth factor-3 gene with seborrhoeic keratosis, allegedly its epidermal counterpart.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Transitional Cell / metabolism. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 18815932.001).
  • [ISSN] 0300-8886
  • [Journal-full-title] Scandinavian journal of urology and nephrology. Supplementum
  • [ISO-abbreviation] Scand J Urol Nephrol Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Genetic Markers
  • [Number-of-references] 57
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62. Tan E, Oakley A, Soyer HP, Haskett M, Marghoob A, Jameson M, Rademaker M: Interobserver variability of teledermoscopy: an international study. Br J Dermatol; 2010 Dec;163(6):1276-81
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  • BACKGROUND: Teledermoscopy is a rapidly developing field of dermatology with studies demonstrating excellent agreement with face-to-face diagnosis.
  • However, we are unaware of studies evaluating interobserver variability in diagnosis between dermatologists from different continents.
  • RESULTS: There was excellent agreement between four of five dermatologists (A-D) for lesions that were agreed upon as melanoma (κ = 0·81-0·97) and benign naevus (κ = 0·77-0·82).The fifth dermatologist (E) made a more frequent diagnosis of atypical naevus and melanoma than the others.
  • For nonmelanocytic lesions, there was moderate to very good agreement for seborrhoeic keratosis (κ = 0·64-0·80) and basal cell carcinoma (κ = 0·55-0·67), but poor agreement for invasive squamous cell carcinoma (SCC) (κ = 0·05-0·15).
  • Agreement for actinic keratosis (κ = 0·32-0·67) and SCC in situ (κ = 0·15-0·32) was only moderate.
  • When atypical and benign naevi were grouped together and actinic keratosis and SCC in situ grouped together, there was better agreement among all dermatologists.
  • CONCLUSIONS: There was good agreement among dermatologists A-D but dermatologist E varied from the group with more frequent diagnosis of melanoma and atypical naevus.
  • [MeSH-major] Dermoscopy / methods. Remote Consultation / standards. Skin Neoplasms / diagnosis

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20795998.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Lebedeva IuV, Davydov AB, Lebedev SN: [Clinical evaluation of prevalence of seborrheic keratosis of face and neck skin among oncological patients]. Stomatologiia (Mosk); 2009;88(5):45-8
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  • [Title] [Clinical evaluation of prevalence of seborrheic keratosis of face and neck skin among oncological patients].
  • The aim was to detect seborrheal keratosis of face and neck in these patients.
  • 280 patient of given age group of maxillo-facial department were controls.
  • Two fold increase in the presence of seborrheal keratosis of face and neck in oncologic patients was found as compared to control group.
  • [MeSH-major] Facial Dermatoses / epidemiology. Keratosis, Seborrheic / epidemiology. Neck. Neoplasms / complications
  • [MeSH-minor] Age Factors. Female. Humans. Male. Middle Aged. Sex Factors. Skin / pathology

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  • (PMID = 20037539.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii︠a︡
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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64. Saini R, Sarnoff DS: Basal cell carcinoma of the vulva presenting as unilateral pruritus. J Drugs Dermatol; 2008 Mar;7(3):288-90
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  • [Title] Basal cell carcinoma of the vulva presenting as unilateral pruritus.
  • Basal cell carcinoma (BCC) is the most common human malignancy, which often occurs as a result of ultraviolet light on sun-exposed areas.
  • A more rare location for the presentation of BCC is the non-sun-exposed genital area, where squamous cell cancer occurs frequently in the setting of human papilloma virus and chronic inflammatory lesions (i.e., lichen sclerosus et atrophicus).
  • A delay in diagnosis can result in wider surgical margins and potential recurrences.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Diagnostic Errors. Pruritus / etiology. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Dermatitis, Allergic Contact / diagnosis. Diagnosis, Differential. Female. Humans. Vulva / pathology

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  • (PMID = 18380212.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Kim JE, Kim HJ, Choi JM, Lee KH, Kim TY, Cho BK, Jung JY, Chung KY, Cho D, Park HJ: The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma. Br J Dermatol; 2010 Nov;163(5):959-67
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  • METHODS: Human cationic antimicrobial protein-18 (hCAP-18)/LL-37 production in several cell lines including HaCaT, a chronic myelogenous leukaemia (CML) cell line and various melanoma cell lines was examined using reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay.
  • After adding LL-37 to a melanoma cell line, tumour cell proliferation, migration and invasion were investigated.
  • RESULTS: Human malignant melanoma cell lines overexpressed hCAP-18/LL-37 mRNA and peptide compared with HaCaT and CML cell lines.
  • Immunohistochemistry showed that the peptide was strongly expressed in malignant melanoma and moderately expressed in squamous cell carcinoma, whereas basal cell carcinoma, precancerous lesions and seborrhoeic keratosis showed no or weak expression.
  • LL-37 also stimulated melanoma cell proliferation, migration and invasion in vitro.
  • LL-37 promoted melanoma cell proliferation, migration and invasion in vitro.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line, Tumor / metabolism. Cell Movement / physiology. Cell Proliferation. Enzyme-Linked Immunosorbent Assay. Female. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Male. Middle Aged. Neoplasm Invasiveness / pathology. Precancerous Conditions / metabolism. RNA, Messenger / metabolism

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20977442.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimicrobial Cationic Peptides; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 143108-26-3 / CAP18 lipopolysaccharide-binding protein
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66. Lally A, Casabonne D, Waterboer T, Imko-Walczuk B, Michael KM, Pawlita M, Newton R, Wojnarowska F: Association of seborrhoeic warts with skin cancer in renal transplant recipients. J Eur Acad Dermatol Venereol; 2010 Mar;24(3):302-7
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  • [Title] Association of seborrhoeic warts with skin cancer in renal transplant recipients.
  • A clinical observation that RTR with skin cancer often had multiple seborrhoeic warts prompted an investigation in RTR into the relationship between seborrhoeic warts and skin cancer and an exploration into potential risk factors for seborrhoeic warts in this population, including infection with human papillomavirus (HPV).
  • Clinical examinations identified seborrhoeic warts.
  • Odds ratios (OR) calculated using unconditional logistic regression analysis to look for associations between skin cancer, HPV infection and seborrhoeic warts, controlling for potential confounding factors of gender, age and time since transplantation.
  • RESULTS: Seborrhoeic warts were associated with non-melanoma skin cancer [OR = 3.7; 95% confidence intervals (CI) ranging from 1.6-8.9; P = 0.002] when confounding factors of gender, age and time since transplantation were controlled for.
  • There was also an association between seborrhoeic warts and viral warts (OR = 3.0, CI: 1.6-5.4; P < 0.0001), but no association between seborrhoeic warts and infection with single or multiple HPV types.
  • CONCLUSIONS: Seborrhoeic warts are associated with cutaneous malignancy, but not with any of the HPV types tested.
  • RTR with multiple seborrhoeic warts may require more regular cutaneous examination to monitor for early signs of skin cancer.
  • [MeSH-major] Dermatitis, Seborrheic / complications. Kidney Transplantation / adverse effects. Skin Neoplasms / etiology. Warts / complications


67. Rozenberg J, Rishi V, Orosz A, Moitra J, Glick A, Vinson C: Inhibition of CREB function in mouse epidermis reduces papilloma formation. Mol Cancer Res; 2009 May;7(5):654-64
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  • [Title] Inhibition of CREB function in mouse epidermis reduces papilloma formation.
  • We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using the keratin 5 promoter.
  • However, following a 7,12-dimethylbenz(a)anthracene (DMBA)/phorbol-12-myristate-13-acetate two-stage skin carcinogenesis experiment, A-CREB-expressing epidermis develop 5-fold fewer papillomas than wild-type controls.
  • However, A-CREB expression one month after DMBA treatment does not prevent papilloma formation, suggesting that CREB functions at an early stage of papilloma formation.
  • In primary keratinocyte cultures, A-CREB expression induced apoptosis of v-Ras(Ha)-infected cells and suppressed the expression of cell cycle proteins cyclin B1 and cyclin D1.
  • [MeSH-major] Cyclic AMP Response Element-Binding Protein / metabolism. Epidermis / metabolism. Papilloma / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene / toxicity. Animals. Animals, Newborn. Apoptosis / physiology. Blotting, Western. Carcinogens / toxicity. Cell Cycle / physiology. Cell Proliferation. Cells, Cultured. Female. Genes, ras / genetics. In Situ Nick-End Labeling. Keratinocytes / cytology. Keratinocytes / metabolism. Male. Mice. Mice, Inbred Strains. Mice, Transgenic. Mutation. Reverse Transcriptase Polymerase Chain Reaction. Skin / drug effects. Skin / metabolism. Skin / pathology. Tetradecanoylphorbol Acetate / toxicity


68. Oliveira MC, Silveira EJ, Godoy GP, Amorim RF, Costa AL, Queiroz LM: Immunohistochemical evaluation of intermediate filament proteins in squamous papilloma and oral verrucous carcinoma. Oral Dis; 2005 Sep;11(5):288-92
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  • [Title] Immunohistochemical evaluation of intermediate filament proteins in squamous papilloma and oral verrucous carcinoma.
  • OBJECTIVE: Cytokeratins (CKs) are the intermediate filament proteins of the epithelium cells, which have become important markers of normal and abnormal cell differentiation.
  • The goal of the present study was to investigate the expression pattern of CK 10, 13, 14 and 16 in oral verrucous carcinoma (OVC) and oral squamous papilloma (OSP).
  • All the cell layers of OVC reacted positively for CK 14 while basal and suprabasal layers of OSP were more pronounced for CK 14.
  • [MeSH-major] Carcinoma, Verrucous / metabolism. Intermediate Filament Proteins / metabolism. Keratins / biosynthesis. Mouth Neoplasms / metabolism. Papilloma / metabolism
  • [MeSH-minor] Cell Proliferation. Cell Transformation, Neoplastic / metabolism. Humans. Immunohistochemistry. Keratinocytes / metabolism

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  • (PMID = 16120114.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 68238-35-7 / Keratins
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69. Reszec J, Sulkowski S: The expression of P53 protein and infection of human papilloma virus in conjunctival and eyelid neoplasms. Int J Mol Med; 2005 Oct;16(4):559-64
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  • [Title] The expression of P53 protein and infection of human papilloma virus in conjunctival and eyelid neoplasms.
  • Human papilloma virus (HPV) infection and loss of P53 function have been identified as frequent events in various human tumors.
  • The aim of this study was to evaluate P53 protein expression and to detect HPV in the tissue samples of 45 benign (papillomas) and 38 malignant conjunctival and eyelid lesions (27 basal cell carcinomas and 11 squamous cell carcinomas).
  • We also looked for eventual relationships between P53 expression and clinicopathological features such as age, histological type of tumor, grading and staging.
  • We revealed P53 protein expression in 30 out of 45 (66.6%) squamous cell papillomas.
  • Malignant type HPV 16 and 18 were detected in three squamous cell papillomas, two BCCs and one SCC.
  • However, we observed P53 protein expression in only two HPV-positive papillomas and one infiltrative type of BCC.
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / virology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Humans. Middle Aged. Papilloma / metabolism. Papilloma / pathology. Papilloma / virology

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  • (PMID = 16142387.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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70. Al-Daraji WI, Al-Dawoud A: Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association. Clin Exp Dermatol; 2005 Mar;30(2):137-40
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  • [Title] Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association.
  • A 75-year-old woman presented to her general practitioner with a keratotic skin lesion on her abdomen.
  • Microscopic examination showed an irritated seborrheic keratosis.
  • Both the spindle cell component and the ganglion cells stained positively for S-100 protein, neurofilament protein and CD56 (Leu-19, NCAM) by routine immunohistochemistry.
  • We describe the second case of primary cutaneous ganglioneuroma associated with seborrheic keratosis.
  • [MeSH-major] Ganglioneuroma / complications. Keratosis, Seborrheic / complications. Skin Neoplasms / complications

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  • (PMID = 15725239.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 12
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71. Peterson J, Shook BA, Wells MJ, Rodriguez M: Cupric keratosis: green seborrheic keratoses secondary to external copper exposure. Cutis; 2006 Jan;77(1):39-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cupric keratosis: green seborrheic keratoses secondary to external copper exposure.
  • We report the case of a patient with a blue-green discoloration of multiple seborrheic keratoses on his chest and back after swimming in a pool for rehabilitation of a back injury.
  • After the patient discontinued water exercises in the swimming pool, the green discoloration of the seborrheic keratoses disappeared rapidly.
  • [MeSH-major] Copper / adverse effects. Environmental Exposure / adverse effects. Keratosis, Seborrheic / etiology. Trace Elements / adverse effects

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  • (PMID = 16475494.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Trace Elements; 059QF0KO0R / Water; 789U1901C5 / Copper
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72. Mancuso M, Gallo D, Leonardi S, Pierdomenico M, Pasquali E, De Stefano I, Rebessi S, Tanori M, Scambia G, Di Majo V, Covelli V, Pazzaglia S, Saran A: Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer. Carcinogenesis; 2009 Feb;30(2):340-7
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  • [Title] Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer.
  • Patched1 heterozygous mice (Ptch1(+/-)) are useful for basal cell carcinoma (BCC) studies, being remarkably susceptible to BCC induction by ultraviolet or ionizing radiation.
  • Analogously, skin carcinogenesis-susceptible (Car-S) mice are elective for studies of papilloma and squamous cell carcinoma (SCC) induction.
  • Remarkably, progression of initially benign papillomas to malignant SCC occurred only in ovariectomized Car-S females.
  • We explored the mechanisms underlying tumor progression and report overexpression of estrogen receptor (ER)-alpha, downregulation of ERbeta and upregulation of cyclin D1 in papillomas from ovariectomized Car-S relative to papillomas from CN females.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Estrogens / physiology. Skin Neoplasms / metabolism
  • [MeSH-minor] Animals. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. Cyclin D1 / metabolism. Disease Models, Animal. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / metabolism. Female. Male. Mice. Neoplasms, Radiation-Induced / metabolism. Neoplasms, Radiation-Induced / pathology. Ovariectomy. Papilloma / metabolism. Papilloma / pathology. Receptors, Cell Surface / genetics. Receptors, Cell Surface / metabolism. Ultraviolet Rays


73. Subhawong AP, Subhawong T, Nassar H, Kouprina N, Begum S, Vang R, Westra WH, Argani P: Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically. Am J Surg Pathol; 2009 Feb;33(2):163-75
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  • [Title] Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically.
  • Basal-like carcinomas (BLCs) of the breast share discriminatory morphologic features with poorly differentiated high-risk human papilloma virus (HPV)-related squamous cell carcinomas of the oropharynx, penis, and vulva.
  • HPV E6 protein also inactivates p53, further compromising the G1-S cell cycle checkpoint.
  • In conclusion, BLC and UTNC, but not HER-2, luminal A, or luminal B carcinomas, frequently demonstrate an Rb-/p16+ phenotype, similar to the HPV-related squamous cell carcinomas that BLC resemble morphologically.

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  • (PMID = 18936692.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA088843; None / None / / P50 CA088843-06A19005; United States / NCI NIH HHS / CA / P50 CA 88843; United States / NCI NIH HHS / CA / P50 CA088843-06A19005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ NIHMS243756; NLM/ PMC2965595
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74. Ponti G, Luppi G, Losi L, Giannetti A, Seidenari S: Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers. J Hematol Oncol; 2010;3:2
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  • Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease.
  • Epidermal growth factor receptor (EGFR) immunohistochemical expression analysis of multiple seborrheic keratoses revealed an intense membranous staining in the basal keratinocytes and in all the upper epidermal layers.
  • Patients with the sign of Leser-Trélat should undergo a diagnostic screening programme for malignant disease along with patients with known Leser-Trélat syndrome who present with a recent acute and florid eruption of their seborrheic keratoses.
  • We propose the importance of combining the molecular features of multiple seborrheic keratoses with EGFR immunohistochemistry analyses to determine the likelihood of Leser-Trélat syndrome and the consequent high risk of underlying multiple visceral malignancies.
  • [MeSH-major] Adenocarcinoma / diagnosis. Intestinal Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Neoplastic Syndromes, Hereditary / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Humans. Keratosis, Seborrheic / complications. Keratosis, Seborrheic / diagnosis. Male

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  • (PMID = 20064244.001).
  • [ISSN] 1756-8722
  • [Journal-full-title] Journal of hematology & oncology
  • [ISO-abbreviation] J Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2820021
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75. Burkhart CG, Burkhart CN: Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses. Skinmed; 2008 Jan-Feb;7(1):15-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of a keratolytic agent with occlusion for topical treatment of hyperkeratotic seborrheic keratoses.
  • BACKGROUND: Seborrheic keratoses are the most common benign tumors in adults.
  • METHODS: A topical 50% urea-containing product under occlusion was applied daily to large and/or thick hyperkeratotic seborrheic keratoses on the truck and extremities.
  • CONCLUSIONS: Hyperkeratotic seborrheic keratoses can be satisfactorily managed with topical agents and scraping with reasonable patient satisfaction.
  • [MeSH-major] Keratolytic Agents / administration & dosage. Keratosis, Seborrheic / drug therapy. Occlusive Dressings

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  • (PMID = 18174808.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratolytic Agents
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76. Kocyigit P, Akay BN, Arica E, Anadolu RY, Erdem C: Post-renal transplantation Leser-Trélat sign associated with carcinoma of the gallbladder: a rare association. Scand J Gastroenterol; 2007 Jun;42(6):779-81
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  • The sign of Leser-Trélat represents the sudden appearance of multiple seborrheic keratoses in association with an underlying malignancy.
  • Here, we report on a 57-year-old man who presented with a sudden increase in the number and size of seborrheic keratoses, particularly on sun-exposed areas 24 years after renal transplantation.
  • [MeSH-major] Gallbladder Neoplasms / pathology. Keratosis, Seborrheic / pathology. Kidney Transplantation

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  • (PMID = 17506003.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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77. Iwata T, Inoue K, Nishiyama N, Izumi N, Mizuguchi S, Morita R, Tsukioka T, Suehiro S, Obatake N, Wakasa K: Pulmonary inverted Schneiderian papilloma causing high serum levels of carcinoembryonic antigen and squamous cell carcinoma-associated antigen: report of a case. Surg Today; 2007;37(9):790-3
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  • [Title] Pulmonary inverted Schneiderian papilloma causing high serum levels of carcinoembryonic antigen and squamous cell carcinoma-associated antigen: report of a case.
  • We report a rare case of inverted Schneiderian papilloma causing exceedingly high serum levels of carcinoembryonic antigen (CEA) and squamous cell carcinoma-associated antigen (SCC).
  • A 74-year-old man presented with a 6-month history of a productive cough, bloody sputa, and dyspnea.
  • Squamous papilloma was diagnosed by histological examination of a bronchoscopic biopsy specimen.
  • To alleviate the patient's symptoms and refine the diagnosis, we performed a right lower lobectomy.
  • No nuclear abnormality or invasion of the basal membrane of the tumor cells was observed.
  • [MeSH-major] Antigens, Neoplasm / immunology. Carcinoembryonic Antigen / blood. Carcinoma, Squamous Cell / immunology. Papilloma, Inverted / immunology. Serpins / immunology

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  • (PMID = 17713735.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carcinoembryonic Antigen; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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78. Siedek V, Schuh T, Wollenberg A: Leser-Trelat sign in metastasized malignant melanoma. Eur Arch Otorhinolaryngol; 2009 Feb;266(2):297-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The Leser-Trelat sign is defined as the association of multiple, eruptive seborrheic keratoses with an internal malignancy of a usually advanced stage.
  • We report the case of malignant melanoma in an 82-year-old man covered with hundreds of greyish-dark seborrheic keratoses resembling a Christmas tree pattern, who was diagnosed with metastasized malignant melanoma involving the parotid gland and lymph nodes.
  • Though the pathogenesis of Leser-Trelat sign is still unknown, spontaneous regression of the seborrheic keratoses following tumor reduction described in some cases argues for a paraneoplastic origin of this highly instructive clinical entity.
  • Physicians should consider a workup for internal malignancy in patients presenting with multiple eruptive seborrheic keratoses.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Melanoma / secondary. Paraneoplastic Syndromes / pathology. Skin Neoplasms / pathology

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  • (PMID = 18369652.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 7GR28W0FJI / Dacarbazine
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79. Ozgul N, Cil AP, Bozdayi G, Usubutun A, Bulbul D, Rota S, Kose MF, Biri A, Haberal A: Staining characteristics of p16INK4a: is there a correlation with lesion grade or high-risk human papilloma virus positivity? J Obstet Gynaecol Res; 2008 Oct;34(5):865-71
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  • [Title] Staining characteristics of p16INK4a: is there a correlation with lesion grade or high-risk human papilloma virus positivity?
  • AIM: The aims of this study were to evaluate the efficiency of p16INK4a in showing cervical lesions and to determine any relationship between lesion grade and high-risk human papilloma virus (HR-HPV) infection and p16INK4a staining characteristics.
  • METHODS: Immunohistochemical analysis of p16INK4a was performed on 13 low-grade squamous intraepithelial lesions (LSIL), 22 high-grade squamous intraepithelial lesions (HSIL), 23 squamous cell carcinoma (SCC) and 25 normal tissue samples.
  • The distribution, staining pattern and intensity of this marker are significantly correlated with the increasing grade of cervical lesions, suggesting that diffuse distribution, full thickness staining pattern and strong intensity of this marker are highly supportive of HSIL and cervical cancer, while focal distribution, scattered/basal staining pattern and weak intensity suggest LSIL.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Cervical Intraepithelial Neoplasia / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Papillomaviridae / isolation & purification. Papillomavirus Infections / metabolism. Uterine Cervical Neoplasms / metabolism

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  • (PMID = 18958930.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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80. Hansen C, Wilkinson D, Hansen M, Argenziano G: How good are skin cancer clinics at melanoma detection? Number needed to treat variability across a national clinic group in Australia. J Am Acad Dermatol; 2009 Oct;61(4):599-604
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The number needed to treat (NNT) is a key measure of the quality of melanoma diagnosis.
  • NNT was calculated with and without seborrheic keratoses.
  • RESULTS: Overall NNT was 30 (with seborrheic keratoses) and 23 (without seborrheic keratoses).
  • Excluding the 4 doctors with NNT greater than 60, total NNT decreased from 30 to 21 and from 23 to 15, respectively (with and without seborrheic keratoses).
  • NNT varied by doctor from 0 to 192 and 117, respectively (with and without seborrheic keratoses).
  • LIMITATIONS: Given the retrospective design, we were unable to examine doctor characteristics such as age, sex, medical training, and patient pressure to excise.
  • [MeSH-major] Ambulatory Care Facilities / standards. Cancer Care Facilities / standards. Melanoma / diagnosis. Quality of Health Care. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Australia. Databases, Factual. Family Practice / standards. Family Practice / statistics & numerical data. Female. Humans. Keratosis, Seborrheic / diagnosis. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19664848.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Hafner C, van Oers JM, Hartmann A, Landthaler M, Stoehr R, Blaszyk H, Hofstaedter F, Zwarthoff EC, Vogt T: High frequency of FGFR3 mutations in adenoid seborrheic keratoses. J Invest Dermatol; 2006 Nov;126(11):2404-7
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  • [Title] High frequency of FGFR3 mutations in adenoid seborrheic keratoses.
  • FGFR3 mutations have also been detected in 40% of seborrheic keratoses (SKs) of the hyperkeratotic and acanthotic subtype, which are very common benign skin tumors.
  • [MeSH-major] Keratosis, Seborrheic / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Skin Neoplasms / genetics

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  • (PMID = 16778799.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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82. Legoupil D, Lemasson G, Davaine AC, Misery L: [Bowen's disease and squamous cell carcinoma in Haber's syndrome: two cases]. Ann Dermatol Venereol; 2007 Jan;134(1):59-61
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  • [Title] [Bowen's disease and squamous cell carcinoma in Haber's syndrome: two cases].
  • [Transliterated title] Maladie de Bowen et carcinome épidermoïde au cours d'un syndrome de Haber: deux cas.
  • Clinically, it is associated with rosaceiform dermatosis of the face that begins in childhood, and profuse keratotic lesions resembling seborrheic keratoses, seen predominantly on the trunk, the tops of the limbs and the scalp.
  • We report two cases of Bowen's disease and cutaneous epidermoid carcinoma in Haber's syndrome patients.
  • OBSERVATIONS: A 67 year-old woman with Haber's syndrome and with a familial history consulted for a budding lesion on the abdomen, histological examination of which confirmed epidermoid carcinoma.
  • A 77 year-old woman presented a clinical picture consistent with Haber's syndrome, with three infiltrated erythematosquamous abdominal lesions.
  • Histological examination of a biopsy sample confirmed the clinical diagnosis of Bowen's disease.
  • We propose the hypothesis of transformation of the keratoses seen in seborrheic keratosis.
  • The use of imiquimod to treat lesions in patients with Bowen's disease resulted in complete cure.
  • [MeSH-major] Bowen's Disease / complications. Carcinoma, Squamous Cell / complications. Keratosis / complications. Neoplasms, Multiple Primary / complications. Rosacea / complications. Skin Neoplasms / complications

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  • (PMID = 17384546.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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83. Dasanu CA, Alexandrescu DT: Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung. South Med J; 2009 Feb;102(2):216-8
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  • In our patient, the Leser-Trélat sign consisted of explosive multiple seborrheic keratoses in combination with acanthosis nigricans, representing a remarkable geometric skin projection of lung cancer which involved both the upper lobes.
  • The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers.

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  • (PMID = 19209445.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Graells J, Espinola A, Barrio C, Muñoz MD, Román A, Parellada N: [Minor cutaneous ambulatory surgery and cryotherapy. Comparative study between a dermatologist and family physicians]. Actas Dermosifiliogr; 2007 Apr;98(3):171-7
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  • [Transliterated title] Cirugía menor ambulatoria dermatológica y crioterapia. Estudio comparativo entre un dermatólogo y médicos de familia.
  • This study compares the diagnosis and treatment in cutaneous surgery, including cryotherapy, between a dermatologist and family physicians.
  • Each lesion was independently evaluated by a dermatologist and a family physician, both of whom assigned the clinical diagnosis and therapeutic advice.
  • Concordance for diagnosis, recommended treatment and indication for cryotherapy was calculated by Cohen's kappa coefficient.
  • Diagnostic concordance was significantly better for melanocytic nevus, achrocordon and for lesions with multiple and monomorphous presentation, and worse for isolated pigmented lesions.
  • For recommended treatment concordance was better for multiple and monomorphous lesions and worse for skin cancer and seborrheic keratosis.
  • For indication of cryotherapy concordance was worse for skin cancer, melanocytic nevus, acrochordon and seborrheic keratosis.
  • Family physicians should be more careful in evaluating solitary pigmented lesions and patients at risk for skin cancer.
  • [MeSH-major] Ambulatory Surgical Procedures. Cryotherapy. Dermatology. Family Practice. Observer Variation. Skin Diseases / diagnosis
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Clinical Competence. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / surgery. Keratosis, Seborrheic / therapy. Male. Middle Aged. Nevus, Pigmented / diagnosis. Nevus, Pigmented / surgery. Nevus, Pigmented / therapy. Prospective Studies. Sampling Studies. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery. Skin Neoplasms / therapy. Warts / diagnosis. Warts / surgery. Warts / therapy

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  • (PMID = 17504701.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
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85. Siqueira CR, Miot HA: [Inflammation of multiple seborrheic keratoses induced by chemotherapy with gemcitabine]. An Bras Dermatol; 2009 Jul-Aug;84(4):410-3

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  • [Title] [Inflammation of multiple seborrheic keratoses induced by chemotherapy with gemcitabine].
  • [Transliterated title] Inflamação de queratoses seborreicas múltiplas induzida por quimioterapia com gencitabina.
  • The authors report inflammation in multiple seborrheic keratoses after chemotherapy with gemcitabine in a patient under treatment for pancreatic cancer.
  • [MeSH-major] Antimetabolites, Antineoplastic / adverse effects. Deoxycytidine / analogs & derivatives. Drug Eruptions / complications. Drug Eruptions / etiology. Keratosis, Seborrheic / chemically induced. Keratosis, Seborrheic / complications

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  • (PMID = 19851675.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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86. Hinckley M, Feldman SR, Fleischer AB, Vallejos QM, Whalley LE, Quandt SA, Heck J, Cabral G, Brooks T, Schulz MR, Arcury TA: Common skin disorders seen in the migrant farmworker health care clinic setting. J Agromedicine; 2007;12(4):71-9
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  • Migrant farmworkers commonly access rural health clinics for diagnosis and treatment of skin disease.
  • The most common conditions were contact dermatitis, melasma, tinea, seborrheic keratoses, and impetigo.

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  • (PMID = 19042681.001).
  • [ISSN] 1059-924X
  • [Journal-full-title] Journal of agromedicine
  • [ISO-abbreviation] J Agromedicine
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / R01-ES012358
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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87. Martínez-García S, del Boz-González J, Martín-González T, Samaniego-González E, Crespo-Erchiga V: [Teledermatology. Review of 917 teleconsults]. Actas Dermosifiliogr; 2007 Jun;98(5):318-24
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  • [Transliterated title] Teledermatología. Revisión de 917 teleconsultas.
  • RESULTS: The majority of the 917 teleconsults performed were for benign lesions, notably seborrheic keratosis in 201 cases; among malignant lesions actinic keratosis appeared in 161 cases and melanoma was diagnosed in 5 cases.
  • Fifty-eight percent of teleconsults have been arranged for a face-to-face consult in order to perform adequate treatment, in 90 % of cases, or to confirm diagnosis or carry out complementary exams, in 10 % of cases.
  • CONCLUSION: The image is the gold standard for dermatological diagnosis.
  • [MeSH-major] Skin Diseases / diagnosis. Telemedicine

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  • (PMID = 17555674.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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88. Slobodin G, Lurie M, Munichor M, Kovalev J, Rosner I: Gottron's papules-like eruption developing under hydroxyurea therapy. Rheumatol Int; 2006 Jun;26(8):768-70
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  • A 57-year-old white female developed a Gottron's papules (GP)-like eruption, without any of the other clinical or laboratory signs of dermatomyositis (DM).
  • Skin biopsy was compatible with seborrheic keratosis.
  • [MeSH-major] Dermatomyositis / diagnosis. Hydroxyurea / adverse effects. Hydroxyurea / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy

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  • (PMID = 16583187.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] X6Q56QN5QC / Hydroxyurea
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89. Kavak A, Parlak AH, Yesildal N, Aydogan I, Anul H: Preliminary study among truck drivers in Turkey: effects of ultraviolet light on some skin entities. J Dermatol; 2008 Mar;35(3):146-50
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  • We also evaluated the effect of occupational duration, age and skin type among this population.
  • Dermatological entities such as actinic keratosis, solar lentigo, seborrheic keratosis, melanocytic nevus, spider angioma, ephelid, basal cell carcinoma (BCC), squamous cell carcinoma, and melanoma were compared to driver and right sides.
  • In addition, drivers were divided into two subgroups according to: (i) age (subgroups A1, 20-40 years, and A2, >40 years);.
  • Seborrheic keratosis and lentigo solaris were found to be increased on the driver side of the face (P = 0.00) and ear (P = 0.013), respectively.
  • Statistically significant increases of lesions on the driver side were determined according to the subgroups: melanocytic nevi were found to be increased on the driver side in A1 (P = 0.00), A2 (P = 0.00), O2 (P = 0.00), S1 (P = 0.00) and S2 (P = 0.006) groups; actinic keratoses were found to be significantly increased on the driver side in A2 and O2 groups (P = 0.03 for both).
  • [MeSH-minor] Adult. Age Factors. Aged. Case-Control Studies. Humans. Middle Aged. Time Factors. Turkey

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  • (PMID = 18346257.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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90. LeAnder R, Chindam P, Das M, Umbaugh SE: Differentiation of melanoma from benign mimics using the relative-color method. Skin Res Technol; 2010 Aug;16(3):297-304
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  • This present work extends the previous studies by applying relative-color feature extraction to dermoscopic images to differentiate among melanoma, seborrheic keratoses and Reed/Spitz nevi.
  • OBJECTIVE: To develop a method for automatically differentiating among malignant melanoma, seborrheic keratoses and Reed/Spitz nevi, using digitized, color, dermoscopic images.
  • RESULTS: The classification rates of melanoma, seborrheic keratoses and Reed/Spitz nevi images mixed together, were 60%, 58.3% and 80%, respectively.
  • Classification rates were the best when melanoma was being differentiated from seborrheic keratoses.
  • The high success rates for differentiating seborrheic keratoses from melanoma show that the use of dermoscopic images has a strong promise in enabling prescreening, as well as automated assistance and significant improvement in tumor diagnosis in clinics.
  • [MeSH-major] Dermoscopy / methods. Image Processing, Computer-Assisted / methods. Keratosis, Seborrheic / diagnosis. Melanoma / diagnosis. Nevus, Epithelioid and Spindle Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Colorimetry / instrumentation. Colorimetry / methods. Diagnosis, Differential. Hair. Humans. Models, Biological. Neoplasms / diagnosis. Skin Pigmentation

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  • (PMID = 20636998.001).
  • [ISSN] 1600-0846
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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91. Minagawa A, Koga H: Dermoscopy of pigmented poromas. Dermatology; 2010 Aug;221(1):78-83
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  • [Title] Dermoscopy of pigmented poromas.
  • BACKGROUND: To date, little is known about the dermoscopic features of pigmented poromas.
  • METHODS: Twelve cases of pigmented poromas examined by dermoscopy at the Department of Dermatology, Shinshu University Hospital (Matsumoto, Japan), between January 2000 and February 2009 were collected.
  • CONCLUSIONS: Pigmented poromas mimic a number of skin tumors, including pigmented basal cell carcinomas, seborrheic keratosis and malignant melanoma, because they present various clinical, dermoscopic and histopathological features.
  • [MeSH-major] Dermoscopy. Pigmentation Disorders / diagnosis. Poroma / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Keratosis, Seborrheic / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Retrospective Studies. Skin Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516657.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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92. Fernandez MP, Wang NS, Terzakis JA, Meehan SA, Kamino H: Histopathology and X-ray microanalysis of foreign material on facial keratoses. Am J Dermatopathol; 2009 May;31(3):232-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathology and X-ray microanalysis of foreign material on facial keratoses.
  • Opaque exogenous material was frequently observed on the surface of keratoses during routine sign out by one of us (H.K.).
  • To investigate this material further, 300 consecutive seborrheic keratoses were reviewed: 100 cases from the face of women, 100 cases from the face of men, and 100 cases from the trunk of men and women.
  • The material was present on 54% of facial keratoses from predominantly older women (mean age 67 years), 5% of facial keratoses from men, and 9% of truncal keratoses from men and women.
  • Further, because the exogenous material was found predominantly on facial keratoses of older women, the presence of this material in a specimen may serve as a clue to the patient's gender, age, and biopsy site.
  • [MeSH-major] Electron Probe Microanalysis. Facial Dermatoses / pathology. Keratosis, Seborrheic / pathology. Skin / pathology

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  • (PMID = 19384063.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Ointments
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93. Hafner C, Di Martino E, Pitt E, Stempfl T, Tomlinson D, Hartmann A, Landthaler M, Knowles M, Vogt T: FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes. Exp Cell Res; 2010 Jul 15;316(12):2008-16
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  • [Title] FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes.
  • FGFR3 mutations have recently been identified in several benign epidermal skin lesions such as seborrheic keratosis, epidermal nevus and solar lentigo.
  • However, at confluence FGFR3 mutant keratinocytes revealed a significantly higher cell number than wildtype cells.
  • Our results suggest that an increased cell number at confluence along with a decreased apoptosis may contribute to the development of acanthotic tumors in FGFR3 mutant skin in vivo.
  • [MeSH-minor] Cell Adhesion. Cell Proliferation. Humans. Phosphorylation

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  • (PMID = 20420824.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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94. Goyal A, Raina S, Kaushal SS, Mahajan V, Sharma NL: Pattern of cutaneous manifestations in diabetes mellitus. Indian J Dermatol; 2010;55(1):39-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: One hundred consecutive patients with the diagnosis of diabetes mellitus and having skin lesions, either attending the diabetic clinic or admitted in medical wards were included in this study.
  • RESULTS: The common skin disorders were: Xerosis (44%), diabetic dermopathy (36%), skin tags (32%), cutaneous infections (31%), and seborrheic keratosis (30%).

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  • [Cites] J Dermatol. 1995 Oct;22(10):729-31 [8586750.001]
  • [Cites] Indian J Dermatol Venereol Leprol. 2003 Mar-Apr;69(2):105-8 [17642848.001]
  • [Cites] Diabetes Care. 2004 May;27(5):1047-53 [15111519.001]
  • [Cites] Diabetes Res Clin Pract. 1998 Feb;39(2):101-6 [9597379.001]
  • (PMID = 20418975.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2856371
  • [Keywords] NOTNLM ; Diabetes mellitus / Western Himalayas / skin lesions
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95. Takahara M, Chen S, Kido M, Takeuchi S, Uchi H, Tu Y, Moroi Y, Furue M: Stromal CD10 expression, as well as increased dermal macrophages and decreased Langerhans cells, are associated with malignant transformation of keratinocytes. J Cutan Pathol; 2009 Jun;36(6):668-74
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  • We analyzed CD10+ stromal cells, dermal macrophages and Langerhans cells (LCs) in skin tumors.
  • METHODS: Immunohistological staining was performed with markers for macrophages (CD68), LC (CD1a), stromal fibroblasts (CD10) and cell proliferation (Ki67) in 12 normal skins (NSs) and 15 cases each of seborrheic keratosis (SK), actinic keratosis (AK), keratoacanthoma (KA), Bowen's disease (BD) and squamous cell carcinoma (SCC).
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Keratinocytes / pathology. Langerhans Cells / pathology. Macrophages / pathology. Neprilysin / biosynthesis. Skin Neoplasms / pathology
  • [MeSH-minor] Bowen's Disease / immunology. Bowen's Disease / metabolism. Bowen's Disease / pathology. Carcinoma, Squamous Cell / immunology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Connective Tissue / immunology. Connective Tissue / metabolism. Fibroblasts / metabolism. Fibroblasts / pathology. Humans. Immunohistochemistry. Keratoacanthoma / immunology. Keratoacanthoma / metabolism. Keratoacanthoma / pathology. Keratosis, Actinic / immunology. Keratosis, Actinic / metabolism. Keratosis, Actinic / pathology. Keratosis, Seborrheic / immunology. Keratosis, Seborrheic / metabolism. Keratosis, Seborrheic / pathology. Skin / cytology. Skin Diseases / immunology. Skin Diseases / metabolism. Skin Diseases / pathology. Stromal Cells / metabolism. Stromal Cells / pathology

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  • (PMID = 19515046.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
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96. El-Zawahry MB, Abdel El-Hameed El-Cheweikh HM, Abd-El-Rahman Ramadan S, Ahmed Bassiouny D, Mohamed Fawzy M: Ultrasound biomicroscopy in the diagnosis of skin diseases. Eur J Dermatol; 2007 Nov-Dec;17(6):469-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasound biomicroscopy in the diagnosis of skin diseases.
  • We aimed to evaluate the accuracy of ultrasound biomicroscopy (UBM) in the diagnosis of eight skin disorders namely, morphea, keloid, lichen planus, chronic eczema, psoriasis, port wine stain, seborrheic keratosis, and photo-aged skin, through correlation of its findings with clinical and pathological assessment.
  • In morphea, the dermal echogenicity was increased and the thickness of morphea plaques correlated significantly with disease severity.
  • Seborrheic keratosis appeared as a sound shadow.
  • We conclude that UBM is a non-invasive diagnostic tool in dermatology which can be used to give valuable information about disease progress and the effectiveness of therapy.

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  • (PMID = 17951126.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] France
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97. Kluger N, Guillot B: Sign of Leser-Trélat with an adenocarcinoma of the prostate: a case report. Cases J; 2009;2:8868

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The sign of Leser-Trélat is defined by the sudden appearance and rapid increase in number and size of seborrheic keratoses, preceding or revealing a malignancy.
  • CASE PRESENTATION: We report the case of a 68-year-old man who experienced sudden increased in number of seborrheic keratoses within two years prior to a diagnosis of adenocarcinoma of the prostate.
  • After prostatectomy, pigmented lesions stopped their brutal increase but did not regress.

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  • [Cites] J Am Acad Dermatol. 1996 Jul;35(1):88-95 [8682971.001]
  • [Cites] Arch Dermatol. 1975 Jun;111(6):792-3 [1169918.001]
  • (PMID = 19918348.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769478
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98. Deprez M, Uffer S: Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol; 2009 May;31(3):256-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benign tumors largely predominated over malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%).
  • Basal cell carcinoma was the most frequent malignant tumor (86%), followed by squamous cell carcinoma (7%) and sebaceous carcinoma (3%).
  • For several tumor subtypes, there was a poor correlation between clinical and histological diagnosis, stressing the numerous pitfalls in the diagnosis of eyelid tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Child. Child, Preschool. Female. Hidrocystoma / pathology. Humans. Infant. Keratosis, Seborrheic / pathology. Male. Middle Aged. Nevus, Pigmented / pathology. Papilloma / pathology. Predictive Value of Tests. Retrospective Studies. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology. Xanthomatosis / pathology. Young Adult

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  • (PMID = 19384066.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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99. Bursztejn AC, Doumat-Batch F, Granel-Brocard F, Perrin A, Cuny JF, Barbaud A, Schmutz JL: [Sézary syndrome and Leser-Trélat sign: a chance association?]. Ann Dermatol Venereol; 2008 Apr;135(4):287-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Syndrome de Sézary et syndrome de Leser-Trélat: association fortuite?
  • BACKGROUND: Leser-Trélat sign involves the combined sudden onset of seborrheic keratosis and cancer.
  • PATIENTS AND METHODS: A 59-year-old woman presented generalized pruritus with secondary appearance of multiple seborrheic keratosis.
  • Extracorporeal photopheresis was initiated, after which there was a marked reduction in the patient's pruritus, erythroderma and numbers of seborrheic keratoses and Sézary cells.
  • Rampen and Schwengle [J Am Acad Dermatol 21 (1989) 50-5] have thrown doubt on this entity because of the "subjective" definition, the frequent dissociation between the course of the tumour and that of the seborrheic keratosis, the disparity between the frequency with which rapid onset seborrheic keratosis is seen and the rarity of cases in which this phenomenon reveals a tumour and the absence of association with any specific type of malignancy.
  • The time between diagnosis of Sézary syndrome and cutaneous symptoms of Leser-Trélat sign appears very long in the present case.
  • [MeSH-major] Keratosis, Seborrheic / complications. Sezary Syndrome / complications. Skin Neoplasms / complications

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  • (PMID = 18420075.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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100. Blomberg M, Jeppesen EM, Skovby F, Benfeldt E: FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature. Dermatology; 2010;220(4):297-305
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present a 14-year-old girl with mild hypochondroplasia who developed acanthosis nigricans.
  • We review the present literature, describing studies in which FGFR3 mutations have been investigated in skin lesions: primarily seborrheic keratoses and epidermal nevi, but also other benign skin tumors and a single case of a squamous cell carcinoma.
  • [MeSH-minor] Adolescent. Blood Glucose / drug effects. C-Peptide / blood. Female. Gonadotropin-Releasing Hormone / therapeutic use. Human Growth Hormone / therapeutic use. Humans. Keratosis, Seborrheic / genetics. Metformin / therapeutic use

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20453470.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / C-Peptide; 12629-01-5 / Human Growth Hormone; 33515-09-2 / Gonadotropin-Releasing Hormone; 9100L32L2N / Metformin; EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
  • [Number-of-references] 54
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