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6. Tseng SH, Huang YH, Chao SC, Lee JY, Chang KC: Conjunctival seborrheic keratosis. Ophthalmology; 2010 Jan;117(1):190-190.e2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival seborrheic keratosis.
  • [MeSH-major] Conjunctival Diseases / diagnosis. Keratosis, Seborrheic / diagnosis
  • [MeSH-minor] Aged. Biomarkers / metabolism. Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / metabolism. Conjunctival Neoplasms / surgery. Diagnosis, Differential. Female. Humans. Neoplasms, Squamous Cell / diagnosis. Neoplasms, Squamous Cell / metabolism. Neoplasms, Squamous Cell / surgery. Ophthalmologic Surgical Procedures

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  • (PMID = 20114109.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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7. Oh WJ, Rishi V, Orosz A, Gerdes MJ, Vinson C: Inhibition of CCAAT/enhancer binding protein family DNA binding in mouse epidermis prevents and regresses papillomas. Cancer Res; 2007 Feb 15;67(4):1867-76
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  • [Title] Inhibition of CCAAT/enhancer binding protein family DNA binding in mouse epidermis prevents and regresses papillomas.
  • The CCAAT/enhancer binding proteins (C/EBP) are a family of B-ZIP DNA binding proteins that act as transcription factors to regulate growth and differentiation of many cell types, including keratinocytes.
  • We expressed A-C/EBP in the basal layer of the skin epidermis during a two-step skin carcinogenesis protocol.
  • A-C/EBP expression caused hyperplasia of the basal epidermis and increased apoptosis in the suprabasal epidermis.
  • The mice developed fewer papillomas and had systemic hair loss.
  • Primary keratinocytes recapitulate the A-C/EBP induction of cell growth and increase in p53 protein.
  • A-C/EBP expression after papilloma development caused the papillomas to regress with an associated increase in apoptosis and up-regulation of p53 protein.
  • Furthermore, A-C/EBP-expressing mice heterozygous for p53 were more susceptible to papilloma formation, suggesting that the suppression of papilloma formation has a p53-dependent mechanism.
  • [MeSH-major] CCAAT-Enhancer-Binding Proteins / antagonists & inhibitors. CCAAT-Enhancer-Binding Proteins / biosynthesis. DNA / metabolism. Papilloma / prevention & control. Skin Neoplasms / prevention & control
  • [MeSH-minor] Animals. Apoptosis / physiology. Cell Growth Processes / physiology. Keratinocytes / cytology. Keratinocytes / metabolism. Mice. Mice, Transgenic. Skin / metabolism. Skin / pathology

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  • (PMID = 17308129.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Proteins; 9007-49-2 / DNA
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8. Hafner C, Vogt T: Seborrheic keratosis. J Dtsch Dermatol Ges; 2008 Aug;6(8):664-77
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  • [Title] Seborrheic keratosis.
  • Seborrheic keratosis is one of the most common skin tumors.
  • Despite its frequency, many aspects of seborrheic keratosis remain elusive.
  • In the last years new molecular genetic insights into seborrheic keratoses have been gained.
  • The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized.
  • [MeSH-major] Clinical Trials as Topic / trends. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / therapy


9. Macaya-Pascual A, López-Canós R, López-Piqueras S, Gómez S: [Analysis of the reasons for consultation and dermatology care cost in a primary care site]. Actas Dermosifiliogr; 2006 Nov;97(9):569-72
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  • [Transliterated title] Análisis de los motivos de consulta y de su coste en la asistencia dermatológica en un centro de Atención Primaria.
  • Endpoints of age, gender, diagnosis, cost per visit, cryotherapy and electrocoagulation were collected.
  • In the latter group, the diagnoses were: seborrheic keratosis 39/455 (9 %), acrocordons 21/455 (5 %), remaining diagnoses (intradermal melanocytic nevi, cherry angioma, solar lentigos): 56/116 (11 %).

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  • [CommentIn] Actas Dermosifiliogr. 2007 Sep;98(7):510-1 [17669312.001]
  • (PMID = 17173759.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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10. Li P, Gao XH, Chen HD, Zhang Y, Wang Y, Wang H, Wang Y, Xie Y: Localization of haptoglobin in normal human skin and some skin diseases. Int J Dermatol; 2005 Apr;44(4):280-4
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  • Haptoglobin can also be detected in the cytoplasm of normal epidermal Langerhans cells (LCs), and can prevent their functional maturation.
  • METHODS: We examined Hp expression at mRNA and protein levels by in situ hybridization and immunohistochemistry, respectively, in normal human skin and in the skin of patients with psoriasis, lichen planus, erythroderma, seborrheic keratosis, verruca vulgaris, basal cell carcinoma, systemic lupus erythematosus, pemphigus and bullous pemphigoid. RESULTS:.
  • (1) Haptoglobin mRNA was expressed in the epidermal keratinocytes (KCs), the epithelial cells of hair follicles, sebaceous glands and eccrine glands in normal skin and all dermatoses investigated. (2) Whereas compared with normal skin, the Hp mRNA in KCs of patients with psoriasis, lichen planus, erythroderma, seborrhoea keratosis and verruca vulgaris was significantly intensified, it was weaker in patients with systemic lupus erythematosus, pemphigus and bullous pemphigoid. (3) Haptoglobin protein only stained positively in some KCs of patients with psoriasis, lichen planus and erythroderma. (4) Although some but not all epidermal LCs were positively stained with anti-Hp antibody in normal skin and in skin samples from all patients, the ratios of Hp-positive LCs/total LCs were significantly higher in those diseases with intensified Hp mRNA in KCs.
  • The expression of Hp mRNA in KCs and the Hp protein in both LCs and KCs appears to be correlated with the amount of inflammation, which might indicate that skin itself is involved in down-regulating the local inflammatory reaction by KC-synthesized Hp.

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  • (PMID = 15811077.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Haptoglobins
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16. Fukushige T, Kanekura T, Ohuchi E, Shinya T, Kanzaki T: Immunohistochemical studies comparing the localization of type XV collagen in normal human skin and skin tumors with that of type IV collagen. J Dermatol; 2005 Feb;32(2):74-83
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  • It was expressed at low levels in seborrheic keratosis and not expressed at all in actinic keratosis and squamous cell carcinoma.
  • [MeSH-minor] Basement Membrane / metabolism. Carcinoma, Squamous Cell / metabolism. DNA, Complementary / analysis. Humans. Immunohistochemistry. Keratosis / metabolism. Melanoma / metabolism. Nevus, Pigmented / metabolism

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  • (PMID = 15906535.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA, Complementary; 9007-34-5 / Collagen
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17. Goon P, Sonnex C, Jani P, Stanley M, Sudhoff H: Recurrent respiratory papillomatosis: an overview of current thinking and treatment. Eur Arch Otorhinolaryngol; 2008 Feb;265(2):147-51
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  • Human papillomaviruses (HPV) infection in benign laryngeal papillomas is well established.
  • Infected host basal cell keratinocytes and papillomas arise from the disordered proliferation of these differentiating keratinocytes.
  • Surgical debulking of papillomas is currently the treatment of choice; newer surgical approaches utilizing microdebriders are replacing laser ablation.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Laser Therapy / methods. Otorhinolaryngologic Surgical Procedures / methods. Papilloma / pathology. Papilloma / surgery

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  • (PMID = 18046565.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 50
  • [Other-IDs] NLM/ PMC2217621
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18. Kopf AW, Rabinovitz H, Marghoob A, Braun RP, Wang S, Oliviero M, Polsky D: "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses. J Am Acad Dermatol; 2006 Dec;55(6):1089-91
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  • [Title] "Fat fingers:" a clue in the dermoscopic diagnosis of seborrheic keratoses.
  • "Fat fingers" are thick digitate linear, curvilinear, branched, or oval/circular dermoscopic structures typically seen in seborrheic keratoses where they represent the gyri of their cerebriform surfaces.
  • Their recognition is very useful in the diagnosis of these lesions, especially when the classic features (eg, milia, comedo-like openings) are absent.
  • Histologically and by confocal microscopy the "fat finger" gyri are accentuated by pigmented keratin filling the sulci.
  • "Fat fingers" must be differentiated from other linear structures such as "network-like structures"; branched streaks; network; globules; pigmented ovoid-nests; and streaks/pseudopods seen in different melanocytic and non-melanocytic lesions.
  • [MeSH-major] Dermoscopy. Keratosis, Seborrheic / diagnosis

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  • (PMID = 17097405.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Ansai S, Kimura T: Rippled-pattern sebaceoma: a clinicopathological study. Am J Dermatopathol; 2009 Jun;31(4):364-6
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  • Eighty cases of sebaceoma, comprising 37 male and 43 female patients with a mean age at resection of 62.9 +/- 17.0 years, were reviewed.
  • Histopathologically, sebaceoma without rippled pattern frequently associated with other neoplastic lesions including sebaceous nevus, seborrheic keratosis, and trichoblastoma on the same lesion; however, there were no associated lesions in rippled-pattern sebaceoma.

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  • (PMID = 19461240.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Bukhari MH, Niazi S, Khaleel ME, Sharif MA, Ghani R, Mehmood MT, Tahseen M, Chaudhry NA, Hasan M: Elevated frequency of p53 genetic mutations and AgNOR values in squamous cell carcinoma. J Cutan Pathol; 2009 Feb;36(2):220-8
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  • [Title] Elevated frequency of p53 genetic mutations and AgNOR values in squamous cell carcinoma.
  • BACKGROUND: Epidermal squamous cell carcinoma (SCC) isa common malignancy in Pakistan.
  • We hypothesize that it is characterized by higher frequency of p53 genetic mutations and increased AgNOR values compared with squamous cell papilloma(SCP) and basal cell carcinoma (BCC).
  • [MeSH-major] Antigens, Nuclear / metabolism. Mutation. Neoplasms, Basal Cell. Papilloma. Skin Neoplasms. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18715257.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / nucleolar organizer region associated proteins
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21. Cribier B: [Seborrheous keratosis]. Ann Dermatol Venereol; 2005 Mar;132(3):292-5
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  • [Title] [Seborrheous keratosis].
  • [MeSH-major] Keratosis, Seborrheic / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans

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  • (PMID = 15924060.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] France
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22. Ghaninejad H, Ehsani AH, Ghiasi M, Noormohammadpour P, Najafi E, Naderi G, Ganji M, Mirnezami M, Nezami R, Kiani P: Benign and malignant skin lesions in renal transplant recipients. Indian J Dermatol; 2009 Jul;54(3):247-50
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  • Skin infections occurred in 83% of the patients and most of them were viral infections (65%), especially of human papilloma viruses (HPVs) in 40% of the patients.
  • The age of developing skin cancer in these patients was early than normal population.
  • CONCLUSION: Our results emphasize the importance of dermatologic examinations and monitoring RTRs to obtain an early diagnosis and treatment of cutaneous manifestations.

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  • (PMID = 20161856.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2810691
  • [Keywords] NOTNLM ; Basal cell carcinoma / Kaposi sarcoma / benign / malignant / renal transplantation / skin lesions / squamous cell carcinomas
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23. Bernard-Pierrot I, Brams A, Dunois-Lardé C, Caillault A, Diez de Medina SG, Cappellen D, Graff G, Thiery JP, Chopin D, Ricol D, Radvanyi F: Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis; 2006 Apr;27(4):740-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Surprisingly, identical somatic activating mutations have been found at the somatic level in tumours: at high frequency in benign epithelial tumours (seborrheic keratosis, urothelial papilloma) and in low-grade, low-stage urothelial carcinomas, and at a lower frequency in other types of urothelial carcinoma, in cervix carcinoma, and in haematological cancer, multiple myeloma.
  • NIH-3T3 cells transfected with a mutated form of FGFR3b--FGFR3b-S249C, the most common mutation in bladder tumours--presented a spindle-cell morphology, grew in soft agar and gave rise to tumours when xenografted into nude mice.
  • We identified one line of 17 bladder cell lines tested (MGH-U3) that expressed a mutated form of FGFR3b, FGFR3b-Y375C.
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Urinary Bladder Neoplasms / genetics

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  • (PMID = 16338952.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Pyrroles; 0 / RNA, Small Interfering; 0 / SU 5402; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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4. Hafner C, Toll A, Fernández-Casado A, Earl J, Marqués M, Acquadro F, Méndez-Pertuz M, Urioste M, Malats N, Burns JE, Knowles MA, Cigudosa JC, Hartmann A, Vogt T, Landthaler M, Pujol RM, Real FX: Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci U S A; 2010 Nov 30;107(48):20780-5
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  • Seborrheic keratoses (SK) are very frequent benign human epidermal tumors without malignant potential.
  • [MeSH-major] Keratosis, Seborrheic / genetics. Keratosis, Seborrheic / pathology. Mutation / genetics. Oncogenes / genetics
  • [MeSH-minor] Apoptosis / genetics. Biomarkers, Tumor. Cell Aging. Cell Proliferation. Clone Cells. DNA Mutational Analysis. Genetic Testing. Genome, Human / genetics. Genotype. Humans. Mitogen-Activated Protein Kinases / genetics. PTEN Phosphohydrolase / metabolism. Phosphatidylinositol 3-Kinases / genetics. Proto-Oncogene Proteins c-akt / genetics. Receptor, Fibroblast Growth Factor, Type 3 / genetics. Signal Transduction / genetics. TOR Serine-Threonine Kinases / metabolism. Tumor Suppressor Proteins / metabolism. ras Proteins / genetics


25. Keskin EA, Gorpelioglu C, Sarifakioglu E, Kafali H: Seborrheic keratoses: a distinctive diagnoses of pigmented vulvar lesions: a case report. Cases J; 2010;3:56
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  • [Title] Seborrheic keratoses: a distinctive diagnoses of pigmented vulvar lesions: a case report.
  • Seborrheic keratoses, a benign growth lesion, is a very common cutaneous lesion encountered in white races in the fourth and fifth decade.
  • A 34-year-old woman reported with a hyperpigmented palpable lesion, approximately 5-10 mm in diameter, was found on the patient's left labium majus.
  • The clinical differential diagnosis of the pigmented lesions of the vulva is difficult often need a biopsy.

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  • [Cites] Dermatol Clin. 1992 Apr;10(2):361-70 [1606765.001]
  • [Cites] Clin Exp Dermatol. 2005 Jan;30(1):17-9 [15663494.001]
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  • (PMID = 20181151.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2834621
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26. Lee JL, Kim A, Kopelovich L, Bickers DR, Athar M: Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. J Invest Dermatol; 2005 Oct;125(4):818-25
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  • Enhanced prostaglandin production via upregulated cyclooxygenase-2 (COX-2) expression is a likely contributing factor in ultraviolet B (UVB)-induced non-melanoma skin cancer (NMSC), which consists primarily of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).
  • [MeSH-minor] Animals. Carcinoma, Basal Cell / chemistry. Carcinoma, Squamous Cell / chemistry. Cyclic AMP / analysis. Cyclooxygenase 2. Cyclooxygenase 2 Inhibitors. Cyclooxygenase Inhibitors / therapeutic use. Female. Humans. Immunohistochemistry. Membrane Proteins. Mice. Mice, Hairless. Papilloma / chemistry. Prostaglandin-Endoperoxide Synthases / analysis. RNA, Messenger / analysis. Receptors, Prostaglandin E, EP1 Subtype. Receptors, Prostaglandin E, EP2 Subtype. Receptors, Prostaglandin E, EP3 Subtype. Receptors, Prostaglandin E, EP4 Subtype

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  • (PMID = 16185283.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-10106-01; United States / NIAMS NIH HHS / AR / K01-AR048582; United States / NCI NIH HHS / CN / N01-CN-15011-72; United States / NCI NIH HHS / CN / N01-CN-15109; United States / NCI NIH HHS / CN / N01-CN-35006-72; United States / NCI NIH HHS / CN / N01-CN-35105; United States / NIAMS NIH HHS / AR / P30 AR 44535; United States / NCI NIH HHS / CA / R01 CA-97249-01; United States / NCI NIH HHS / CA / T32 CA09685; United States / NCI NIH HHS / CA / U19 CA 81888
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Cyclooxygenase Inhibitors; 0 / Membrane Proteins; 0 / PTGER1 protein, human; 0 / PTGER2 protein, human; 0 / PTGER3 protein, human; 0 / PTGER4 protein, human; 0 / Ptger1 protein, mouse; 0 / Ptger2 protein, mouse; 0 / Ptger3 protein, mouse; 0 / Ptger4 protein, mouse; 0 / RNA, Messenger; 0 / Receptors, Prostaglandin E; 0 / Receptors, Prostaglandin E, EP1 Subtype; 0 / Receptors, Prostaglandin E, EP2 Subtype; 0 / Receptors, Prostaglandin E, EP3 Subtype; 0 / Receptors, Prostaglandin E, EP4 Subtype; E0399OZS9N / Cyclic AMP; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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27. Birnie AJ, Varma S: A dermatoscopically diagnosed collision tumour: malignant melanoma arising within a seborrhoeic keratosis. Clin Exp Dermatol; 2008 Jul;33(4):512-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A dermatoscopically diagnosed collision tumour: malignant melanoma arising within a seborrhoeic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic. Dermoscopy / methods. Humans. Male. Treatment Outcome

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  • [CommentIn] Clin Exp Dermatol. 2009 Oct;34(7):e371-2 [19486048.001]
  • (PMID = 18462448.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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28. Briscoe C: Readers respond to "I use fingernail surgery to remove my seborrheic keratoses". MedGenMed; 2007;9(2):4
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  • [Title] Readers respond to "I use fingernail surgery to remove my seborrheic keratoses".
  • [MeSH-major] Keratosis, Seborrheic / surgery. Nails. Self Care / methods

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  • [CommentOn] MedGenMed. 2006;8(4):66 [17415340.001]
  • (PMID = 17977073.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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29. Dreyer J: Readers respond to "I use fingernail surgery to remove my seborrheic keratoses". MedGenMed; 2007;9(2):4
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  • [Title] Readers respond to "I use fingernail surgery to remove my seborrheic keratoses".
  • [MeSH-major] Keratosis, Seborrheic / surgery. Nails. Self Care / methods

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  • [CommentOn] MedGenMed. 2006;8(4):66 [17415340.001]
  • (PMID = 17977071.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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30. Stelkovics E, Korom I, Marczinovits I, Molnar J, Rasky K, Raso E, Ficsor L, Molnar B, Kopper L, Krenacs T: Collagen XVII/BP180 protein expression in squamous cell carcinoma of the skin detected with novel monoclonal antibodies in archived tissues using tissue microarrays and digital microscopy. Appl Immunohistochem Mol Morphol; 2008 Oct;16(5):433-41
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  • [Title] Collagen XVII/BP180 protein expression in squamous cell carcinoma of the skin detected with novel monoclonal antibodies in archived tissues using tissue microarrays and digital microscopy.
  • In this work, highly sensitive monoclonal antibodies 6D1 and 9G2 were produced, characterized, and used for the detection of collagen XVII in a tissue microarray series of archived samples of nonmelanocytic epithelial neoplasias, including 5 verruca vulgaris, 14 seborrheic keratosis, 38 actinic keratosis, 38 basal cell carcinoma (BCC), 15 basosquamous carcinoma, 58 squamous cell carcinoma (SCC), and 9 normal skin.
  • In normal skin and benign epidermal lesions, collagen XVII protein was restricted to basal keratinocytes.
  • Collagen XVII immunostaining of atypical keratinocytes in most actinic/solar keratosis supports the view of their malignancy and common origin with SCC.
  • Squamous component of basosquamous carcinoma showed moderate reaction, whereas islets of BCC were mainly negative reflecting the diverse genotype and phenotype, and pathogenesis of SCC and BCC.

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  • (PMID = 18633319.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Autoantigens; 0 / Biomarkers, Tumor; 0 / Non-Fibrillar Collagens; 0 / collagen type XVII
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56. Zaballos P, Ara M, Puig S, Malvehy J: Clinical and dermoscopic image of an intermediate stage of regressing seborrheic keratosis in a lichenoid keratosis. Dermatol Surg; 2005 Jan;31(1):102-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and dermoscopic image of an intermediate stage of regressing seborrheic keratosis in a lichenoid keratosis.
  • [MeSH-major] Keratosis / pathology. Keratosis, Seborrheic / pathology. Lichen Planus / pathology

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  • (PMID = 15720105.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Lally A, Casabonne D, Waterboer T, Imko-Walczuk B, Michael KM, Pawlita M, Newton R, Wojnarowska F: Association of seborrhoeic warts with skin cancer in renal transplant recipients. J Eur Acad Dermatol Venereol; 2010 Mar;24(3):302-7
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  • [Title] Association of seborrhoeic warts with skin cancer in renal transplant recipients.
  • A clinical observation that RTR with skin cancer often had multiple seborrhoeic warts prompted an investigation in RTR into the relationship between seborrhoeic warts and skin cancer and an exploration into potential risk factors for seborrhoeic warts in this population, including infection with human papillomavirus (HPV).
  • Clinical examinations identified seborrhoeic warts.
  • Odds ratios (OR) calculated using unconditional logistic regression analysis to look for associations between skin cancer, HPV infection and seborrhoeic warts, controlling for potential confounding factors of gender, age and time since transplantation.
  • RESULTS: Seborrhoeic warts were associated with non-melanoma skin cancer [OR = 3.7; 95% confidence intervals (CI) ranging from 1.6-8.9; P = 0.002] when confounding factors of gender, age and time since transplantation were controlled for.
  • There was also an association between seborrhoeic warts and viral warts (OR = 3.0, CI: 1.6-5.4; P < 0.0001), but no association between seborrhoeic warts and infection with single or multiple HPV types.
  • CONCLUSIONS: Seborrhoeic warts are associated with cutaneous malignancy, but not with any of the HPV types tested.
  • RTR with multiple seborrhoeic warts may require more regular cutaneous examination to monitor for early signs of skin cancer.
  • [MeSH-major] Dermatitis, Seborrheic / complications. Kidney Transplantation / adverse effects. Skin Neoplasms / etiology. Warts / complications


58. Halleck P, Loddenkemper C, Hummel M, Scherer H, Haisch A: [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description]. HNO; 2009 May;57(5):480-3
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  • [Title] [Hyperkeratotic inverted seborrheic keratosis of the outer auditory canal : a first description].
  • [Transliterated title] Hyperkeratotische invertierte seborrhoische Keratose des äusseren Gehörgangs : Eine Erstbeschreibung.
  • Seborrheic keratosis is one of the most common benign neoplasms seen at the trunk, extremities, head and neck of older individuals which rarely occurs in the auditory canal.
  • Even rarer is the occurrence of an inverted or hyperkeratotic variant in this localization.
  • We present the clinical picture of a 74-year-old man with a recurrent hyperkeratotic, partially inverted seborrheic keratosis of the right external auditory canal.
  • This disease is sometimes difficult to diagnose, particulary to mark down malignant lesions.
  • An uncritical diagnosis must be avoided, since these lesions and especially the irritated subtype might be falsely assessed as basal cell carcinomas which they may resemble histologically.
  • [MeSH-major] Ear Diseases / diagnosis. Ear, External / pathology. Keratosis, Seborrheic / diagnosis

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  • [Cites] Otolaryngol Head Neck Surg. 1987 Feb;96(2):198-201 [2960940.001]
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  • (PMID = 17468841.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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59. Schulz H: [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?]. Hautarzt; 2010 Dec;61(12):1061-2
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  • [Title] [Pigmented lesion on the temple. Pigment cell tumor, basal cell carcinoma, or irritated seborrheic keratosis?].
  • [Transliterated title] Pigmentierte Läsion der Schläfenregion. Melanozytärer Tumor, Basalzellkarzinom oder irritierte seborrhoische Keratose?
  • 33-year-old woman with a red-brown plaque on the temple.
  • Histopathological diagnosis revealed an irritated seborrheic keratosis.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Facial Neoplasms / diagnosis. Keratosis, Seborrheic / diagnosis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Adult. Biopsy. Dermoscopy. Diagnosis, Differential. Female. Forehead. Humans. Skin / pathology

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  • [Cites] Dermatol Clin. 2001 Apr;19(2):347-57 [11556243.001]
  • [Cites] Arch Dermatol. 2002 Dec;138(12):1556-60 [12472342.001]
  • (PMID = 21069503.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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60. Kullander J, Forslund O, Dillner J: Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev; 2009 Feb;18(2):472-8
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  • [Title] Staphylococcus aureus and squamous cell carcinoma of the skin.
  • Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought.
  • We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with biopsies from healthy skin of these 353 immunocompetent patients.
  • In a S. aureus-specific PCR, targeting the nuc gene, presence of S. aureus DNA was strongly associated with SCC (29.3% positive specimens; adjusted odds ratio, 6.23; 95% confidence interval, 3.10-12.53) compared with healthy skin (5.7% positive specimens).
  • There was also a tendency for association of S. aureus with actinic keratosis, but no association was found for basal cell carcinoma or seborrhoeic keratosis.
  • [MeSH-major] Carcinoma, Squamous Cell / microbiology. Staphylococcus aureus / isolation & purification
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / microbiology. Case-Control Studies. DNA, Bacterial / analysis. Female. Humans. Keratosis, Actinic / microbiology. Keratosis, Seborrheic / microbiology. Logistic Models. Male. Middle Aged. Polymerase Chain Reaction. Precancerous Conditions / microbiology

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  • (PMID = 19155437.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial
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61. Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H, Takeuchi S, Tu YT, Moroi Y, Furue M: Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2. Br J Dermatol; 2009 Feb;160(2):442-5
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  • BACKGROUND: The enzyme mammalian target of rapamycin (mTOR) integrates many different cellular signals to control cell growth and proliferation, protein synthesis and breakdown, and other processes.
  • To date, there has been no report on the expression of protein kinase B (AKT)/mTOR cell signalling in epidermal tumours.
  • METHODS: Immunohistological staining was performed with phosphorylated (p-) AKT, p-mTOR, p-4E-binding protein 1 (p-4EBP1), p-ribosomal protein S6 (p-S6), p-p70 ribosomal protein S6 kinase 1 (p-p70S6K1) and CDK2 in 15 cases each of seborrhoeic keratosis, actinic keratosis, keratoacanthoma and Bowen's disease (BD), and 25 cases of squamous cell carcinoma (SCC).
  • [MeSH-major] Bowen's Disease / metabolism. Carcinoma, Squamous Cell / metabolism. Cyclin-Dependent Kinase 2 / metabolism. Keratosis, Actinic / pathology. Sirolimus / pharmacology. Skin Neoplasms / metabolism


62. Grenier J, Soria JC, Mathieu MC, Andre F, Abdelmoula S, Velasco V, Morat L, Besse B, Dunant A, Spielmann M, Delaloge S: Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res; 2007 Jan-Feb;27(1B):547-55
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  • [Title] Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast.
  • BACKGROUND: Pure or metaplastic squamous cell carcinoma (SCC) of the breast is a rare entity with an unclear pathogeny and aggressive clinical behaviour.
  • PATIENTS AND METHODS: Twenty-seven cases of SCC (pure or not) of the breast were matched with 27 ductal invasive carcinomas (IDC) for age, tumour size, nodal involvement and year of diagnosis.
  • The presence of the human papilloma virus (HPV) genome was investigated by polymerase chain reaction (PCR).
  • RESULTS: Pure and metaplastic SCC displayed common profiles typifying a basal origin: they never expressed ER or PR, were HER2-negative in 93% of cases, exhibited positivity for CK5/6 or EGF-R in 75% and 85%, and for p63 in 70% of cases and were highly proliferative.
  • A typical "basal-like" phenotype was displayed that may explain part of their behaviour and justify specific therapeutic approaches.
  • [MeSH-major] Biomarkers, Tumor / analysis. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Squamous Cell / pathology


63. Rass K, Hamsch C: [Differential diagnosis of verrucous skin changes. When wild warts grow rapidly...]. MMW Fortschr Med; 2005 Sep 22;147(38):59-61
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  • [Title] [Differential diagnosis of verrucous skin changes. When wild warts grow rapidly...].
  • This article gives and overview of the various types of verrucous skin changes (viral warts, seborrheic warts).
  • [MeSH-major] Warts / diagnosis
  • [MeSH-minor] Adult. Age Factors. Aged. Carcinoma, Basal Cell / diagnosis. Child. Child, Preschool. Condylomata Acuminata / diagnosis. Condylomata Acuminata / epidemiology. Diagnosis, Differential. Female. Humans. Male. Melanoma / diagnosis. Molluscum Contagiosum / diagnosis. Molluscum Contagiosum / epidemiology. Risk Factors. Sex Factors. Skin Neoplasms / diagnosis

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  • (PMID = 16218230.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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64. van der Avoort IA, van de Nieuwenhof HP, Otte-Höller I, Nirmala E, Bulten J, Massuger LF, van der Laak JA, Slootweg PJ, de Hullu JA, van Kempen LC: High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva. Hum Pathol; 2010 Oct;41(10):1475-85
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  • The molecular pathogenesis of human papilloma virus-unrelated vulvar squamous cell carcinoma is not well known.
  • Whether malignant progression of lichen sclerosus and differentiated vulvar intraepithelial neoplasia to vulvar squamous cell carcinoma could be accompanied by altered DNA content has not been studied extensively.
  • DNA content in isolated nuclei of microdissected normal vulvar epithelium (n = 2), lichen sclerosus (n = 9), differentiated vulvar intraepithelial neoplasia (n = 13), and squamous cell carcinoma (n = 17) from 22 patients was measured via DNA image cytometry.
  • Thirty-eight percent (5/13) of differentiated vulvar intraepithelial neoplasia lesions and 65% (11/17) of squamous cell carcinomas were DNA aneuploid or tetraploid.
  • In lesions that contained differentiated vulvar intraepithelial neoplasia and adjacent squamous cell carcinoma, the ploidy status of differentiated vulvar intraepithelial neoplasia did not exceed that of squamous cell carcinoma.
  • Similarly, we found p53-positive nonproliferating cells with increased DNA content in the superficial compartment of 6 additional solitary differentiated vulvar intraepithelial neoplasia lesions that were not associated with squamous cell carcinoma, indicating ascending aneuploid cells from the basal compartment.
  • DNA ploidy measurements suggest that differentiated vulvar intraepithelial neoplasia has a higher malignant potential than lichen sclerosus and thus is a more likely precursor of squamous cell carcinoma.
  • [MeSH-major] Aneuploidy. Carcinoma in Situ / metabolism. Carcinoma, Squamous Cell / metabolism. DNA / genetics. Precancerous Conditions / metabolism. Tumor Suppressor Protein p53 / biosynthesis. Vulvar Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. DNA, Neoplasm / genetics. Epithelium / metabolism. Epithelium / pathology. Female. Humans. Middle Aged. Vulva / metabolism. Vulva / pathology. Vulvar Lichen Sclerosus / genetics. Vulvar Lichen Sclerosus / metabolism. Vulvar Lichen Sclerosus / pathology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20656324.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Tumor Suppressor Protein p53; 9007-49-2 / DNA
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65. Sharma P, Sarma DP, Adickes ED: Seborrheic keratosis with in-situ squamous cell carcinoma changes. Dermatol Online J; 2006;12(7):19
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  • [Title] Seborrheic keratosis with in-situ squamous cell carcinoma changes.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology


71. Lim C: Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions. Australas J Dermatol; 2006 May;47(2):109-13
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  • [Title] Seborrhoeic keratoses with associated lesions: a retrospective analysis of 85 lesions.
  • Seborrhoeic keratoses are benign epidermal neoplasms that are rarely associated with other skin lesions especially malignancies.
  • In this study, the aim was to assess the incidence of associated lesions occurring either adjacent to or contiguous with a seborrhoeic keratosis.
  • In total, 639 consecutive histologically diagnosed seborrhoeic keratoses were identified, of which 85 (9%) were found to be associated with other lesions.
  • Of these associated lesions, 44 (7%) were malignant, with four of these found to be arising within the seborrhoeic keratosis.
  • The average age was 74 years (range 33-98 years).
  • Seborrhoeic keratoses associated with other lesions were found most commonly on the head and neck.
  • The incidence of associated lesions, in particular malignancy arising within seborrhoeic keratoses may be higher than previously thought.
  • This may be an incidental phenomenon, or seborrhoeic keratosis could represent a precursor lesion.
  • Therefore, seborrhoeic keratoses that have undergone recent clinical change should be considered for biopsy and histological examination.
  • [MeSH-major] Keratosis, Seborrheic / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Extremities. Head. Humans. Medical Records. Melanoma / epidemiology. Melanoma / etiology. Melanoma / pathology. Middle Aged. Neck. New South Wales / epidemiology. Precancerous Conditions. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637806.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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72. Repertinger S, Wang J, Adickes E, Sarma DP: Melanoma in-situ arising in seborrheic keratosis: a case report. Cases J; 2008;1(1):263
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  • [Title] Melanoma in-situ arising in seborrheic keratosis: a case report.
  • BACKGROUND: Seborrheic keratosis is a very common benign skin tumor in man.
  • A melanoma arising in a seborrheic keratosis is distinctly rare.
  • We are reporting such a case occurring in an 86-year-old man.
  • CASE PRESENTATION: An-86-year-old male with a history of multiple actinic keratoses and seborrheic keratoses of the head and trunk presented with a mid-back skin lesion.
  • The biopsied lesion was composed of the usual features of hyperkeratotic seborrheic keratosis, but with focal atypical melanocytic proliferation with nesting along the dermal-epidermal junction.
  • We interpreted this lesion as a melanoma in-situ arising within a seborrheic keratosis.
  • CONCLUSION: It is not uncommon for many physicians to remove a typical seborrheic keratosis without a confirmatory microscopic confirmation.

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  • [Cites] Australas J Dermatol. 2006 May;47(2):109-13 [16637806.001]
  • [Cites] J Am Acad Dermatol. 2000 May;42(5 Pt 1):831-3 [10775864.001]
  • [Cites] Dermatol Surg. 2004 Apr;30(4 Pt 1):559-61 [15056152.001]
  • [Cites] Am J Dermatopathol. 1996 Jun;18(3):278-82 [8806962.001]
  • (PMID = 18947402.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2577645
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73. Madan V, Cox NH, Gangopadhayay M: Porocarcinoma arising in a broad clonal seborrhoeic keratosis. Clin Exp Dermatol; 2008 May;33(3):350-1
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  • [Title] Porocarcinoma arising in a broad clonal seborrhoeic keratosis.
  • [MeSH-major] Bowen's Disease / pathology. Eccrine Glands / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2009 Oct;34(7):e371-2 [19486048.001]
  • [CommentOn] Clin Exp Dermatol. 2007 Jan;32(1):54-6 [17004985.001]
  • (PMID = 18261140.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers
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74. Livaoglu M, Karacal N, Gücer H, Arvas L: Giant genital seborrheic keratosis. Dermatol Surg; 2007 Nov;33(11):1357-8
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  • [Title] Giant genital seborrheic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Genital Diseases, Male / diagnosis. Humans. Male

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  • [CommentIn] Dermatol Surg. 2008 Nov;34(11):1615 [18823349.001]
  • (PMID = 17958589.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Wentzensen N, von Knebel Doeberitz M: Biomarkers in cervical cancer screening. Dis Markers; 2007;23(4):315-30
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  • Cervical cancer is induced by persistent infections with oncogenic human papilloma viruses (HPV).
  • Progression is characterized by the deregulated expression of the viral oncogenes E6 and E7 in infected basal and parabasal cells.
  • [MeSH-major] Biomarkers. Mass Screening / methods. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor. Cell Proliferation. Cervical Intraepithelial Neoplasia / diagnosis. Cervical Intraepithelial Neoplasia / genetics. Cervical Intraepithelial Neoplasia / virology. Chromosomal Instability. Chromosome Aberrations. Epigenesis, Genetic. Female. Genes, Viral. Humans. Neoplasm Invasiveness. Oncogenes. Papillomaviridae / genetics. Papillomaviridae / isolation & purification. Papillomaviridae / pathogenicity. Vaginal Smears


76. Hultgren TL, Srinivasan SK, DiMaio DJ: Epidermodysplasia verruciformis occurring in a patient with human immunodeficiency virus: a case report. Cutis; 2007 Apr;79(4):307-11
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  • Epidermodysplasia verruciformis (EV) is an uncommon dermatosis associated with human papillomavirus (HPV) infection in association with defects in cell-mediated immunity.
  • Malignant transformation to squamous cell carcinoma has been associated with lesions caused by HPV-5, HPV-8, and HPV-14.
  • Clinically, the disease may be confused with verruca plana, seborrheic keratosis, and pityriasis versicolor.
  • Although EV typically is viewed as a disease of childhood, sometimes presenting in patients with a family history of the disease, it rarely may be seen in immunocompromised adults.

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  • (PMID = 17500379.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Park JM, Tsao H, Tsao S: Combined use of intense pulsed light and Q-switched ruby laser for complex dyspigmentation among Asian patients. Lasers Surg Med; 2008 Feb;40(2):128-33
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  • Many individuals exhibit mixed pigmentary entities including melasma, flat/small seborrheic keratoses, ephelides, solar lentigines and acquired bilateral nevus-of-Ota-like macules (ABNOM).

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  • (PMID = 18306166.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Tan E, Oakley A, Soyer HP, Haskett M, Marghoob A, Jameson M, Rademaker M: Interobserver variability of teledermoscopy: an international study. Br J Dermatol; 2010 Dec;163(6):1276-81
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  • BACKGROUND: Teledermoscopy is a rapidly developing field of dermatology with studies demonstrating excellent agreement with face-to-face diagnosis.
  • However, we are unaware of studies evaluating interobserver variability in diagnosis between dermatologists from different continents.
  • RESULTS: There was excellent agreement between four of five dermatologists (A-D) for lesions that were agreed upon as melanoma (κ = 0·81-0·97) and benign naevus (κ = 0·77-0·82).The fifth dermatologist (E) made a more frequent diagnosis of atypical naevus and melanoma than the others.
  • For nonmelanocytic lesions, there was moderate to very good agreement for seborrhoeic keratosis (κ = 0·64-0·80) and basal cell carcinoma (κ = 0·55-0·67), but poor agreement for invasive squamous cell carcinoma (SCC) (κ = 0·05-0·15).
  • Agreement for actinic keratosis (κ = 0·32-0·67) and SCC in situ (κ = 0·15-0·32) was only moderate.
  • When atypical and benign naevi were grouped together and actinic keratosis and SCC in situ grouped together, there was better agreement among all dermatologists.
  • CONCLUSIONS: There was good agreement among dermatologists A-D but dermatologist E varied from the group with more frequent diagnosis of melanoma and atypical naevus.
  • [MeSH-major] Dermoscopy / methods. Remote Consultation / standards. Skin Neoplasms / diagnosis

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20795998.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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79. Porta N, San Juan J, Grasa MP, Simal E, Ara M, Querol MA: [Diagnostic agreement between primary care physicians and dermatologists in the health area of a referral hospital]. Actas Dermosifiliogr; 2008 Apr;99(3):207-12
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  • [Transliterated title] Estudio de concordancia diagnóstica en Dermatología entre Atención Primaria y Especializada en el área de salud de un hospital de referencia.
  • This study aimed to investigate the characteristics of referrals from primary care centers to dermatology specialists as well as the correlation between the presenting complaint and the final dermatologic diagnosis.
  • The agreement between the presenting complaint and the final dermatologic diagnosis was studied.
  • Primary care physicians were found to over diagnose diseases caused by papillomavirus and the diagnostic sensitivity was very low for diseases such as basal cell carcinoma and seborrheic keratosis.
  • [MeSH-major] Dermatology. Primary Health Care. Skin Diseases / diagnosis

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  • (PMID = 18358196.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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80. Monteagudo B, Alvarez-Alvarez C, López-Mouriño VM: [Eruptive seborrheic keratoses triggered by eczema]. Actas Dermosifiliogr; 2005 Mar;96(2):130
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  • [Title] [Eruptive seborrheic keratoses triggered by eczema].
  • [Transliterated title] Queratosis seborreicas eruptivas desencadenadas por un eczema.
  • [MeSH-major] Acanthoma / complications. Eczema / complications. Keratosis, Seborrheic / etiology. Skin Neoplasms / complications

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  • (PMID = 16476353.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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81. Goetze S, Ziemer M, Kaatz M, Lipman RD, Elsner P: Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study. Dermatol Surg; 2006 May;32(5):661-8
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  • [Title] Treatment of superficial surgical wounds after removal of seborrheic keratoses: a single-blinded randomized-controlled clinical study.
  • OBJECTIVE: To evaluate the wound-healing activity of a commercially available hydrocolloid wound dressing (Avery H2460, Avery Dennison, Turnhout, Belgium) in comparison with a control treatment (Fucidine cream with Cutiplast sterile dressing) in superficial wounds after surgical removal of seborrheic keratoses.
  • Sixteen patients between 18 and 80 years of age with seborrheic keratoses were enrolled.
  • [MeSH-major] Bandages, Hydrocolloid. Keratosis, Seborrheic / surgery

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  • (PMID = 16706761.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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82. Hoshina D, Akiyama M, Hata H, Aoyagi S, Sato-Matsumura KC, Shimizu H: Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis. Clin Exp Dermatol; 2007 Jan;32(1):54-6
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  • [Title] Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis.
  • An association between seborrhoeic keratosis (SK) and malignant tumours is considered to be rare.
  • We observed a case of eccrine porocarcinoma and Bowen's disease (BD) occurring synchronously, forming one lesion in a SK on the abdomen.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma / pathology. Eccrine Glands. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentIn] Clin Exp Dermatol. 2008 May;33(3):350-1 [18261140.001]
  • (PMID = 17004985.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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83. Dréno B, Euvrard S, Frances C, Moyse D, Nandeuil A: Effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients. Eur J Dermatol; 2007 Mar-Apr;17(2):140-5
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  • In several studies selenium has shown its role in preventing various carcinomas, it was worth investigating whether it could prevent skin cancer linked to human papilloma virus (HPV).
  • Occurrence rates of warts and various keratoses (main criterion) and of skin cancers (secondary criterion) were compared in the two groups, using Kaplan-Meyer analyses.
  • When both arms were pooled, phenotype and age were not found to be discriminatory factors, whereas a previous history of an actinic keratosis significantly increased the risk of developing a skin cancer by 17.5%.
  • The occurrence of skin cancer was higher if there had been a previous actinic keratosis, highlighting the importance of early dermatological follow-up of the transplanted population.
  • [MeSH-minor] Administration, Oral. Adolescent. Adult. Aged. Carcinoma, Basal Cell / prevention & control. Carcinoma, Basal Cell / virology. Carcinoma, Squamous Cell / prevention & control. Carcinoma, Squamous Cell / virology. Double-Blind Method. Female. France. Humans. Male. Middle Aged. Papillomaviridae. Treatment Outcome

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  • (PMID = 17337398.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] H6241UJ22B / Selenium
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84. Kuroiwa Y, Okamura T, Ishii Y, Umemura T, Tasaki M, Kanki K, Mitsumori K, Hirose M, Nishikawa A: Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation. Cancer Sci; 2008 Jan;99(1):7-13
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  • After 32 weeks of the combined treatment, a significant increase in the incidence of epithelial hyperplasias of the lower-middle and lowest parts of the esophagus were observed compared with the basal-diet group, along with exacerbation of dysplasia and extension of the lesions.
  • Additionally, one squamous cell papilloma was found only in the combined-treatment group.
  • The incidence of hyperplasia was enhanced in all segments, along with the incidence and multiplicity of squamous cell papillomas in the lowest segment of the esophagus.
  • [MeSH-major] Ascorbic Acid / toxicity. Carcinoma, Squamous Cell / etiology. Esophageal Neoplasms / etiology. Esophagitis, Peptic / complications. Sodium Nitrite / toxicity
  • [MeSH-minor] Animals. Antioxidants / toxicity. Cocarcinogenesis. Disease Models, Animal. Food Preservatives / toxicity. Male. Rats. Rats, Inbred F344

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  • (PMID = 17953708.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Food Preservatives; M0KG633D4F / Sodium Nitrite; PQ6CK8PD0R / Ascorbic Acid
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85. Honeycutt KA, Waikel RL, Koster MI, Wang XJ, Roop DR: The effect of c-myc on stem cell fate influences skin tumor phenotype. Mol Carcinog; 2010 Apr;49(4):315-9
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  • [Title] The effect of c-myc on stem cell fate influences skin tumor phenotype.
  • Nonmelanoma skin cancers (NMSCs) consist of a variety of tumor types including basal cell carcinoma, squamous cell carcinoma, a variety of hair follicle tumors, and sebaceous gland tumors.
  • Our goal in the current study was to determine if alterations in the commitment of multipotent stem cells to different cell fates would influence tumor phenotype.
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene / toxicity. Adenocarcinoma, Sebaceous / pathology. Animals. Carcinogens / toxicity. Cell Differentiation / genetics. Cell Lineage / genetics. Crosses, Genetic. Female. Heterozygote. Male. Mice. Mice, Inbred ICR. Mice, Inbred Strains. Mice, Transgenic. Multipotent Stem Cells / pathology. Papilloma / pathology. Phenotype. Sebaceous Gland Neoplasms / pathology. Tetradecanoylphorbol Acetate / pharmacology. Transgenes

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  • (PMID = 20146250.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR47898; United States / NCI NIH HHS / CA / CA09197; United States / NCI NIH HHS / CA / CA105491; United States / NCI NIH HHS / CA / CA52607; United States / NCI NIH HHS / CA / CA79998
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Proto-Oncogene Proteins c-myc; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; NI40JAQ945 / Tetradecanoylphorbol Acetate
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86. Brodsky J: Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea. Curr Opin Otolaryngol Head Neck Surg; 2009 Aug;17(4):315-20
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  • [Title] Management of benign skin lesions commonly affecting the face: actinic keratosis, seborrheic keratosis, and rosacea.
  • RECENT FINDINGS: Actinic keratosis can now be treated with photodynamic therapy or with many topical agents, as alternatives to traditional surgical techniques.
  • Seborrheic keratosis, as well as actinic keratosis and rosacea, are now often treated with laser therapy.
  • [MeSH-major] Facial Dermatoses / therapy. Keratosis, Actinic / therapy. Keratosis, Seborrheic / therapy. Rosacea / therapy


87. Noiles K, Vender R: Are all seborrheic keratoses benign? Review of the typical lesion and its variants. J Cutan Med Surg; 2008 Sep-Oct;12(5):203-10
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  • [Title] Are all seborrheic keratoses benign? Review of the typical lesion and its variants.
  • BACKGROUND: Seborrheic keratosis (SK) is one of the more common benign epidermal neoplasms seen in adult and middle-aged patients.
  • RESULTS: Six subtypes of SK were identified: dermatosis papulosa nigra, stucco keratosis, inverted follicular keratosis, large cell acanthoma, lichenoid keratosis, and flat seborrheic keratosis.
  • [MeSH-major] Keratosis, Seborrheic / classification. Skin Neoplasms / classification

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  • (PMID = 18845088.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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88. Hinckley M, Feldman SR, Fleischer AB, Vallejos QM, Whalley LE, Quandt SA, Heck J, Cabral G, Brooks T, Schulz MR, Arcury TA: Common skin disorders seen in the migrant farmworker health care clinic setting. J Agromedicine; 2007;12(4):71-9
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  • Migrant farmworkers commonly access rural health clinics for diagnosis and treatment of skin disease.
  • The most common conditions were contact dermatitis, melasma, tinea, seborrheic keratoses, and impetigo.

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  • (PMID = 19042681.001).
  • [ISSN] 1059-924X
  • [Journal-full-title] Journal of agromedicine
  • [ISO-abbreviation] J Agromedicine
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / R01-ES012358
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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89. Tsai TM, Wu YH, Yang KC, Yang CY, Tsai TH, Chan JY: Sebaceous carcinoma associated with seborrheic keratosis. J Cutan Med Surg; 2010 Sep-Oct;14(5):240-4
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  • [Title] Sebaceous carcinoma associated with seborrheic keratosis.
  • BACKGROUND: The association of a seborrheic keratosis with other common cutaneous neoplasms such as basal cell carcinoma and Bowen disease has been reported, but the association between a seborrheic keratotis and a malignant neoplasm with sebaceous differentiation is very unusual.
  • OBJECTIVE: We present a case of two contiguous neoplasms, a seborrheic keratosis and a sebaceous carcinoma, and discuss the possibility of malignant change in a seborrheic keratosis as an explanation for the findings.
  • METHODS AND RESULTS: A 57-year-old man presented with an asymptomatic tumor on the skin of his abdomen that was composed of two separate but contiguous lesions.
  • Histopathologic examination revealed that the plaque was composed of two different adjacent tumors, including a central portion showing findings consistent with a sebaceous carcinoma and a peripheral part showing a seborrheic keratosis.
  • CONCLUSION: Although the association is likely to be a coincidence and probably represents a collision tumor, the possibility that the sebaceous carcinoma represents malignant degeneration of the seborrheic keratosis cannot be entirely excluded.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20868621.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Rossi R, Bruscino N, Ricceri F, Grazzini M, Dindelli M, Lotti T: Photodynamic treatment for viral infections of the skin. G Ital Dermatol Venereol; 2009 Feb;144(1):79-83
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  • Photodynamic therapy (ALA/MAL-PDT) is indicated for the treatment of actinic keratoses, for superficial, nodular basal cell carcinoma and for Bowen's disease; there is evidence that PDT can be active also against bacteria, viruses and fungi.
  • The new indications for PDT include many types of viral skin infections human papilloma virus (HPV)-related as verrucae of feet and hands, Condylomata acuminata, periungueal warts, epidermodysplasia verruciformis, but also viral skin lesions non HPV related as molluscum contagiosum and herpes simplex can be successfully treated.
  • [MeSH-minor] Condylomata Acuminata / drug therapy. Epidermodysplasia Verruciformis / drug therapy. Herpes Simplex / drug therapy. Humans. Molluscum Contagiosum / drug therapy. Papillomaviridae / isolation & purification. Papillomavirus Infections / drug therapy. Treatment Outcome. Warts / drug therapy

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  • (PMID = 19218913.001).
  • [ISSN] 0392-0488
  • [Journal-full-title] Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia
  • [ISO-abbreviation] G Ital Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Photosensitizing Agents
  • [Number-of-references] 26
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91. Garcia MS, Azari R, Eisen DB: Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. Dermatol Surg; 2010 Dec;36(12):1968-72
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  • BACKGROUND: Dermatosis papulosa nigra (DPN) is a common variant of seborrheic keratoses in darkly pigmented individuals.

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  • [Copyright] © 2010 by the American Society for Dermatologic Surgery, Inc.
  • (PMID = 21040130.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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92. Lipozenčić J, Bukvić Mokos Z: Dermatologic lasers in the treatment of aging skin. Acta Dermatovenerol Croat; 2010;18(3):176-80
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  • The major clinical features of aging skin include xerosis, laxity, wrinkles, slackness, and the occurrence of benign neoplasms such as seborrheic keratoses and cherry angiomas.
  • Photoaging is characterized by dryness (roughness), actinic keratoses, irregular pigmentation (freckling, lentigines, guttate hypomelanosis, persistent hyperpigmentation), wrinkling, stellate pseudoscars, elastosis (fine nodularity and/or coarseness), inelasticity, telangiectasia, venous lakes, purpura (easy bruising), comedones (maladie de Favre et Racouchot) and sebaceous hyperplasia.
  • In this manuscript laser resurfacing and laser therapy of vascular and pigmented lesions of aging skin will be overviewed.

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  • (PMID = 20887699.001).
  • [ISSN] 1847-6538
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
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93. Scope A, Benvenuto-Andrade C, Agero AL, Marghoob AA: Nonmelanocytic lesions defying the two-step dermoscopy algorithm. Dermatol Surg; 2006 Nov;32(11):1398-406
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  • The first step of the two-step algorithm of dermoscopy aims at differentiating melanocytic from nonmelanocytic pigmented lesions, using a stepwise evaluation for the presence of specific dermoscopic criteria.
  • Seborrheic keratosis, solar lentigo, dermatofibroma, and supernumerary accessory nipple may present with network-like structures.
  • Seborrheic keratosis, dermatofibroma, subcorneal hemorrhage, basal cell carcinoma (BCC), and cutaneous metastases of breast and other cancers may contain pigmented globules.
  • Peripheral streaks can also be seen in seborrheic keratosis and BCC.
  • This overlap of features between melanocytic and nonmelanocytic lesions suggests that integration of all dermoscopic features in the lesion, rather than a stepwise evaluation, may facilitate reaching the correct diagnosis in select cases as outlined in this article.
  • [MeSH-major] Algorithms. Dermoscopy / methods. Melanoma, Amelanotic / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17083595.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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94. Biel M: Advances in photodynamic therapy for the treatment of head and neck cancers. Lasers Surg Med; 2006 Jun;38(5):349-55
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  • Photodynamic therapy (PDT) is an FDA-approved minimally invasive medical treatment modality that utilizes light in the presence of oxygen to activate photosensitizing agents that are relatively selectively concentrated in abnormal or neoplastic cells resulting in cell death.
  • In the United States, US Food and Drug administration approval has been given for the use of PDT in the treatment of Barrett's esophagus, obstructing esophageal carcinoma and early and obstructing tracheobronchial carcinoma using the photosensitizer Photofrin; actinic keratosis using the photosensitizer Levulan (aminolevulinic acid); and macular degeneration using the photosensitizer BPD.
  • In the EU the above noted indications have also been approved in addition to the treatment of early head and neck cancers and palliative treatment of head and neck cancer using the photosensitizer Foscan; and treatment of basal and squamous cell skin cancers using the photosensitizer Metvix.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ambulatory Care. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Humans. Male. Melanoma / therapy. Middle Aged. Minnesota / epidemiology. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / therapy. Papilloma / therapy. Retrospective Studies. Sarcoma, Kaposi / therapy

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16788923.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 97067-70-4 / Dihematoporphyrin Ether
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95. Laing ME, O'Keane C, Murphy GM: Basal cell carcinoma arising in a seborrhoeic keratosis. Clin Exp Dermatol; 2009 Oct;34(7):e371-2
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  • [Title] Basal cell carcinoma arising in a seborrhoeic keratosis.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Keratosis, Seborrheic / complications. Skin Neoplasms / etiology

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  • [CommentOn] Clin Exp Dermatol. 2008 Jul;33(4):512-3 [18462448.001]
  • [CommentOn] Clin Exp Dermatol. 2008 May;33(3):350-1 [18261140.001]
  • (PMID = 19486048.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] England
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96. Ferreira M, Fujiwara H, Morita K, Watt FM: An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors. Cancer Res; 2009 Feb 15;69(4):1334-42
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  • One of these, T188Ibeta1, was identified as a heterozygous mutation in a poorly differentiated squamous cell carcinoma (SCC) and shown to activate extracellular matrix adhesion and inhibit keratinocyte differentiation in vitro.
  • To study its contribution to tumor development, we overexpressed the mutant or wild-type (WT) human beta1 subunit in the basal layer of mouse epidermis using the keratin 14 promoter.
  • The transgenic integrins were expressed at the cell surface and were functional, with the T188Ibeta1 subunit promoting cell spreading to a greater extent than WTbeta1.
  • Epidermal proliferation and differentiation were unaffected and no expansion of the stem cell compartment was detected.
  • During chemical carcinogenesis, both transgenes increased papilloma formation, but only the T188Ibeta1 transgene stimulated the conversion of papillomas to SCCs.
  • Papillomas bearing the mutation showed increased Erk activity and reduced differentiation.
  • [MeSH-minor] Animals. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Cell Adhesion. Cell Differentiation. Cell Division. Female. Flow Cytometry. Heterozygote Detection. Humans. In Situ Hybridization. Keratinocytes / cytology. Keratinocytes / physiology. Mice. Mice, Transgenic. Polymerase Chain Reaction. Polymorphism, Genetic. Skin / cytology


97. Culbertson GR: 532-nm diode laser treatment of seborrheic keratoses with color enhancement. Dermatol Surg; 2008 Apr;34(4):525-8; discussion 528
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  • [Title] 532-nm diode laser treatment of seborrheic keratoses with color enhancement.
  • BACKGROUND: Seborrheic keratoses (SKs) are benign cutaneous tumors of the epidermis.
  • Hypopigmentation occurred in 6% of patients and was associated with old, chronic, or recalcitrant lesions.
  • [MeSH-major] Color Therapy. Keratosis, Seborrheic / therapy. Laser Therapy / methods. Lasers, Semiconductor

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  • (PMID = 18248487.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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98. Terada T: Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis. Int J Clin Oncol; 2010 Dec;15(6):608-10
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  • [Title] Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis.
  • A 76-year-old man consulted to our hospital complaining of a black tumor of the temporal head.
  • A clinical diagnosis of basal cell carcinoma was made, and an excision with wide margins was performed.
  • The cells were heavily pigmented.
  • The periphery of the tumor showed typical features of pigmented reticulated seborrheic keratosis.
  • This case suggests that pigmented Bowen disease can arise in pigmented reticulated seborrheic keratosis.
  • [MeSH-major] Bowen's Disease / etiology. Carcinoma, Basal Cell / complications. Keratosis, Seborrheic / complications. Skin Neoplasms / etiology

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  • [Cites] J Dermatol Surg Oncol. 1988 Jul;14(7):765-9 [3292613.001]
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  • (PMID = 20425131.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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99. Chen QP, Aw DC: Epidemiology of skin diseases in renal transplant recipients in a tertiary hospital. Ann Acad Med Singapore; 2010 Dec;39(12):904-5
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  • RESULTS: Our study showed that except the common drug specific skin manifestations, sebaceous hyperplasia (56.6%), seborrheic keratosis (60.8%), melanocytic naevi (76.9%), skin tags (37.1%) and viral (29.4%) and fungal (20.3%) infections were the most prevalent skin diseases among renal transplant recipients living in Singapore.
  • The prevalence of pre-malignant and malignant tumours was very low (11.2% actinic keratosis, 1.4% Bowen's disease, 1.4% squamous cell carcinoma, 0.7% basal cell carcinoma, 0.7% keratoacanthoma).
  • Male predominance was seen in sebaceous hyperplasia (72.4% vs 32.1%), actinic keratosis (17.2% vs 1.8%), viral (36.8% vs 19.6%) and fungal (27.6% vs 8.9%) infections.
  • Our study also showed increased prevalence of sebaceous hyperplasia with increased age but its prevalence was significantly higher than that reported in the age matched general population.
  • The prevalence of seborrheic keratosis, actinic keratosis and viral infection correlated positively with post-transplant duration.
  • It emphasises the importance of dermatologic follow-up for renal transplant patients in order to obtain a diagnosis and manage treatable skin diseases.

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  • (PMID = 21274486.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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100. Fernandez MP, Wang NS, Terzakis JA, Meehan SA, Kamino H: Histopathology and X-ray microanalysis of foreign material on facial keratoses. Am J Dermatopathol; 2009 May;31(3):232-5
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  • [Title] Histopathology and X-ray microanalysis of foreign material on facial keratoses.
  • Opaque exogenous material was frequently observed on the surface of keratoses during routine sign out by one of us (H.K.).
  • To investigate this material further, 300 consecutive seborrheic keratoses were reviewed: 100 cases from the face of women, 100 cases from the face of men, and 100 cases from the trunk of men and women.
  • The material was present on 54% of facial keratoses from predominantly older women (mean age 67 years), 5% of facial keratoses from men, and 9% of truncal keratoses from men and women.
  • Further, because the exogenous material was found predominantly on facial keratoses of older women, the presence of this material in a specimen may serve as a clue to the patient's gender, age, and biopsy site.
  • [MeSH-major] Electron Probe Microanalysis. Facial Dermatoses / pathology. Keratosis, Seborrheic / pathology. Skin / pathology

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  • (PMID = 19384063.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Ointments
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