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1. Raasch B: Management of superficial basal cell carcinoma: focus on imiquimod. Clin Cosmet Investig Dermatol; 2009;2:65-75

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of superficial basal cell carcinoma: focus on imiquimod.
  • Superficial basal cell carcinoma comprise up to 25% of all histological sub-types.
  • They are more likely to occur on younger persons and females and although generally more common on the trunk, also occur frequently on the exposed areas of the head and neck especially in areas of high sun exposure.
  • Imiquimod 5% cream has been shown to stimulate the innate and cell mediated immune system.
  • The short-term success of imiquimod 5% cream in randomized controlled trials comparing different treatment regimes and dosing as a treatment for small superficial basal cell carcinoma (BCC) not on the face or neck is in the range of 82% for 5 times per week application.

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  • (PMID = 21436969.001).
  • [ISSN] 1178-7015
  • [Journal-full-title] Clinical, cosmetic and investigational dermatology
  • [ISO-abbreviation] Clin Cosmet Investig Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3047930
  • [Keywords] NOTNLM ; imiquimod / skin cancer / superficial basal cell carcinoma
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2. Handjani F, Shahbaz S, Sari-Aslani F, Aghaei S, Ali-Zadeh AA: A giant polypoid basal cell carcinoma of the lower extremity. Arch Iran Med; 2010 Mar;13(2):153-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A giant polypoid basal cell carcinoma of the lower extremity.
  • Less than 1% of basal cell carcinomas are giant basal cell carcinomas.
  • Giant basal cell carcinomas are rare.
  • They preferentially involve the trunk and are commonly associated with neglect.
  • Giant basal cell carcinomas of 10 cm or greater are associated with a high rate of metastasis.
  • We report a case of giant basal cell carcinoma of the leg which is not associated with neglect and no signs of metastasis, despite being more than 10 cm in diameter.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Giant Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Leg. Male. Skin / pathology

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  • (PMID = 20187672.001).
  • [ISSN] 1735-3947
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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3. Tarallo M, Cigna E, Frati R, Delfino S, Innocenzi D, Fama U, Corbianco A, Scuderi N: Metatypical basal cell carcinoma: a clinical review. J Exp Clin Cancer Res; 2008;27:65
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for metatypical basal cell carcinoma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metatypical basal cell carcinoma: a clinical review.
  • BACKGROUND: Metatypical cell carcinoma can be considered as a new entity of skin cancer, being an intermediate typology between basal cell carcinomas and squamous cell carcinomas.
  • The behaviour of the metatypical cell carcinoma lies between these two varieties of skin cancer.
  • It is difficult to perform a differential diagnosis based on morphological and clinical features - therefore it is only possible by accurate histology.
  • METHODS: The authors have retrospectively analysed clinical records of 240 patients who were affected by metatypical skin cancer and who were treated by surgery, radiotherapy and chemotherapy.
  • The most affected site was the cervicofacial area, 71.7%; then the trunk, 10%; the limbs, 9.6%; the scalp 3.7%; and other regions 5%.
  • CONCLUSION: In this manuscript, the authors have emphasised the importance of conducting a differential diagnosis, and the importance of the specific treatment for metatypical skin cancer, even though more clinical studies and long-term follow-ups are required before establishing specific guidelines.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 18992138.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 55
  • [Other-IDs] NLM/ PMC2585560
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4. Khan MK, Powell S, Cox N, Robson A, Murrant N: Cervical in-transit metastasis from a truncal basal cell carcinoma. BMJ Case Rep; 2010;2010
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical in-transit metastasis from a truncal basal cell carcinoma.
  • The authors describe a rare case in which a cervical metastatic basal cell carcinoma (BCC) occurred from a small, non-ulcerated primary lesion on the trunk of a female patient.
  • [MeSH-major] Carcinoma, Basal Cell / secondary. Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Skin Neoplasms / pathology

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  • (PMID = 22767568.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027951
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5. Neale RE, Davis M, Pandeya N, Whiteman DC, Green AC: Basal cell carcinoma on the trunk is associated with excessive sun exposure. J Am Acad Dermatol; 2007 Mar;56(3):380-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma on the trunk is associated with excessive sun exposure.
  • BACKGROUND AND OBJECTIVE: Basal cell carcinoma (BCC) is the most common of all cancers.
  • A high proportion of lesions arise on the trunk, which is generally much less exposed to the sun than the head, the major site affected.
  • We tested the hypothesis that the phenotypic determinants and patterns of sun exposure that give rise to BCC on the head and trunk vary in a way that explains the anomalous site distribution.
  • METHODS: The study was set in the context of the Nambour Skin Cancer Study, a community-based follow-up study among 1621 participants with virtually complete ascertainment of BCCs between 1992 and 2004.
  • We compared phenotypic and sun exposure characteristics of participants who developed a first BCC of the head or trunk with those of participants who had no diagnosis of BCC.
  • RESULTS: BCCs of the trunk were more likely to occur in men; they also occurred at a younger age than BCCs of the head.
  • There was a positive association between sun sensitivity and BCC of the head that was absent for BCC of the trunk.
  • A high number of solar keratoses conferred a greater than 3-fold risk for BCCs of both the head and the trunk.
  • BCCs of the trunk had a particularly strong association with the number of reported sunburns and solar lentigines on the trunk, whereas many lentigines conferred a greater than 3-fold risk of truncal BCC compared with a 50% increased risk of BCC of the head.
  • CONCLUSIONS: BCCs of the trunk are the result of overexposure of the sensitive basal cells of the epidermis to ultraviolet radiation.
  • This may result from acute intense exposures sufficient to cause sunburn among people whose ability to tan makes the skin of their face generally less susceptible to the carcinogenic effects of ultraviolet radiation.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Environmental Exposure. Neoplasms, Radiation-Induced. Skin Neoplasms / etiology. Sunlight / adverse effects

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  • (PMID = 17097387.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Chen CC, Chen CL: Clinical and histopathologic findings of superficial basal cell carcinoma: A comparison with other basal cell carcinoma subtypes. J Chin Med Assoc; 2006 Aug;69(8):364-71
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and histopathologic findings of superficial basal cell carcinoma: A comparison with other basal cell carcinoma subtypes.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common cancer in white populations.
  • The trunk was the most common area where SBCC arose.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16970272.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China (Republic : 1949- )
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7. Richmond-Sinclair NM, Pandeya N, Ware RS, Neale RE, Williams GM, van der Pols JC, Green AC: Incidence of basal cell carcinoma multiplicity and detailed anatomic distribution: longitudinal study of an Australian population. J Invest Dermatol; 2009 Feb;129(2):323-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence of basal cell carcinoma multiplicity and detailed anatomic distribution: longitudinal study of an Australian population.
  • A proportion of individuals are affected multiple times by basal cell carcinoma (BCC), but the rate and extent to which this occurs is unknown.
  • Between 1997 and 2006, 663 BCCs were confirmed in 301 of 1,337 participants in the population-based Nambour Skin Cancer Study.
  • Among the multiply and singly affected alike, site-specific BCC incidence rates were far highest on facial subsites, followed by upper limbs, trunk, and then lower limbs.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Face / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 18668137.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Elamin I, Zecević RD, Vojvodić D, Medenica L, Pavlović MD: Cytokine concentrations in basal cell carcinomas of different histological types and localization. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Jun;17(2):55-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokine concentrations in basal cell carcinomas of different histological types and localization.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common malignant skin tumor.
  • OBJECTIVE: We were interested in comparing cytokine levels in BCC and cutaneous squamous cell tumors with BCC of different localization and histological subtypes.
  • MATERIAL AND METHODS: Explants from freshly excised BCC from 18 patients, and cutaneous squamous cell tumors (solar keratoses and Bowen's disease) from 9 patients were cultivated for 24 h.
  • RESULTS: Tissue explants of BCC contained significantly higher concentrations of IL-1beta, IL-4, IL-5, and IL-6 compared to those of squamous cell tumors.
  • Higher levels of TNF-alpha (p = 0.042), IL-4 (p = 0.028), and IL-5 (p = 0.012) were found in tumors localized to the head and neck compared to those on the trunk or extremities.
  • [MeSH-major] Carcinoma, Basal Cell / chemistry. Cytokines / analysis. Skin Neoplasms / chemistry
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / chemistry. Female. Humans. Interleukin-4 / analysis. Interleukin-5 / analysis. Male. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 18709290.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovenia
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-5; 0 / Tumor Necrosis Factor-alpha; 207137-56-2 / Interleukin-4
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9. McPherson T, Ogg G: Spontaneous resolution of basal cell carcinoma in naevoid basal cell carcinoma syndrome/Gorlin's syndrome. Clin Exp Dermatol; 2009 Dec;34(8):e884-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous resolution of basal cell carcinoma in naevoid basal cell carcinoma syndrome/Gorlin's syndrome.
  • We describe a 10-year-old patient with naevoid basal cell carcinoma syndrome (NBCCS) which was diagnosed when she was 3 years old.
  • She has developed multiple basal cell carcinomas (BCCs) over this time, in particular on her face and trunk.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 20055856.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Scalvenzi M, Lembo S, Francia MG, Balato A: Dermoscopic patterns of superficial basal cell carcinoma. Int J Dermatol; 2008 Oct;47(10):1015-8
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  • [Title] Dermoscopic patterns of superficial basal cell carcinoma.
  • BACKGROUND: Superficial basal cell carcinoma (BCC) presents as a scaly, pink to red-brown patch and is predominantly located on the trunk.
  • Clinical diagnosis may not be always easy and implicates a variety of differential diagnoses; in this situation dermoscopy has been reported improving the diagnostic accuracy.
  • LIMITATIONS: Study population referred to skin lesion clinic.
  • Other dermoscopic features, such as leaf-like areas, arborizing telangiectasias, blue-gray globules and large blue-gray ovoid nests, are not strongly associated with the diagnosis of superficial BCC but they are useful in the differential diagnosis from other pigmented and nonpigmented skin lesions.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy. Skin Neoplasms / pathology

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  • (PMID = 18986346.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Raasch BA, Buettner PG, Garbe C: Basal cell carcinoma: histological classification and body-site distribution. Br J Dermatol; 2006 Aug;155(2):401-7
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  • [Title] Basal cell carcinoma: histological classification and body-site distribution.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common cancer worldwide in white-skinned populations.
  • METHODS: A case series of BCC from a prospective population-based register study collecting information on all excised and histologically confirmed skin cancers in Townsville, north Australia between 1997 and 1999.
  • An exception was superficial BCC in males, where the posterior trunk was second, followed by the neck.
  • CONCLUSIONS: The study found a higher rate of superficial BCC than previous studies from less sun-exposed countries, and a more equal distribution of superficial BCC on face, trunk and limbs.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16882181.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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12. Motegi S, Nagai Y, Tamura A, Ishikawa O: Multiple skin cysts in nevoid basal cell carcinoma syndrome: a case report and review of the literature. Dermatology; 2008;216(2):159-62
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  • [Title] Multiple skin cysts in nevoid basal cell carcinoma syndrome: a case report and review of the literature.
  • We report a 72-year-old man with nevoid basal cell carcinoma syndrome (NBCCS) who presented with 25 skin cysts on his trunk and extremities.
  • Fourteen of 25 skin cysts (56%) were observed on his hands.
  • However, 4 skin cysts (4/16; 25%) showed a corrugated or festooned inner surface of wall without a granular cell layer, which resembled an odontogenic keratocyst, a characteristic feature of skin cysts in NBCCS.
  • A review of the literature suggested that acral localization of skin cysts is a distinctive feature of NBCCS.
  • In addition, the histological findings of skin cysts resembling an odontogenic keratocyst might be a hallmark of NBCCS.
  • [MeSH-major] Basal Cell Nevus Syndrome / complications. Cysts / complications. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Skin Diseases / complications. Skin Diseases / diagnosis


13. Yazici AC, Unal S, Ikizoglu G, Kokturk A, Baz K, Cinel L, Koca A: Superficial basal cell carcinoma of the scalp mimicking seborrhoeic dermatitis. Scand J Plast Reconstr Surg Hand Surg; 2006;40(1):54-6
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  • [Title] Superficial basal cell carcinoma of the scalp mimicking seborrhoeic dermatitis.
  • Superficial basal cell carcinomas (BCC) comprise 9% to 11% of BCC, and are commonly found on the trunk or limbs.
  • Any erythematous plaque-type lesion of long duration must have superficial BCC considered in the differential diagnosis.

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  • (PMID = 16428215.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Hafner C, Klein A, Landthaler M, Vogt T: Clonality of basal cell carcinoma arising in an epidermal nevus. New insights provided by molecular analysis. Dermatology; 2009;218(3):278-81
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  • [Title] Clonality of basal cell carcinoma arising in an epidermal nevus. New insights provided by molecular analysis.
  • Non-organoid non-epidermolytic (keratinocytic) epidermal nevi are benign congenital skin lesions following the lines of Blaschko.
  • We report a case of a patient who developed 2 basal cell carcinomas in an extensive epidermal nevus on the trunk.
  • Molecular analysis of a biopsy containing both basal cell carcinoma and epidermal nevus revealed a PIK3CA mutation.
  • Further analysis suggested that this mutation is present in the basal cell carcinoma rather than in the epidermal nevus.
  • The results favour an independent origin of the basal cell carcinoma, although a possible clonal relationship between both lesions cannot be completely excluded on the basis of the molecular genetic findings.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Nevus / genetics. Skin Neoplasms / genetics

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  • [Copyright] 2008 S. Karger AG, Basel
  • (PMID = 19122450.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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15. Kuzmina N, Talme T, Lapins J, Emtestam L: Non-invasive preoperative assessment of basal cell carcinoma of nodular and superficial types. Skin Res Technol; 2005 Aug;11(3):196-200
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  • [Title] Non-invasive preoperative assessment of basal cell carcinoma of nodular and superficial types.
  • BACKGROUND/AIMS: Although various biophysical properties can be used to distinguish basal cell carcinoma (BCC) tissue from normal skin, none permits typing of the tumour.
  • Measurements were also made in healthy skin on the contralateral side as reference.
  • The diagnosis was confirmed by histological examination.
  • Since most of the NBCC were located on the face and most SBCC on the trunk, their baseline impedance characteristics (i.e., impedance indices magnitude index (MIX) and imaginary part index (IMIX)) differed significantly.
  • CONCLUSIONS: As with LD and TEWL, definite differences in IMP were detected between healthy skin and BCC lesions.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 15998331.001).
  • [ISSN] 0909-752X
  • [Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
  • [ISO-abbreviation] Skin Res Technol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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16. Bogdanić B, Smud S, Bagatin D, Nola M, Mijatović D, Majerović M: Giant basal cell carcinoma of the back: a case report and review of the literature. Coll Antropol; 2009 Mar;33(1):315-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant basal cell carcinoma of the back: a case report and review of the literature.
  • Basal cell carcinoma (BCC) is the most common cutaneous malignancy and the most common human malignancy in general.
  • Out of all basal cell carcinomas, giant basal cell carcinoma represents less than 1%.
  • Only 10% of all basal cell carcinomas are located on the trunk and majority is located on the head and neck.
  • We describe a patient with a exophytic giant basal cell carcinoma of the back size 8.5 x 8 x 6 cm, infiltrating skin 1.5 cm.
  • Two years after the lesion has occurred, diagnosis was made by pathohistological analysis.
  • Review of the literature that refers to giant basal cell carcinoma was carried out.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 19408644.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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17. Lovatt TJ, Lear JT, Bastrilles J, Wong C, Griffiths CE, Samarasinghe V, Roebuck J, Ramachandran S, Smith AG, Jones PW, Fryer AA, Strange RC: Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors. J Am Acad Dermatol; 2005 Mar;52(3 Pt 1):468-73
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  • [Title] Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors.
  • BACKGROUND: Patients with basal cell carcinoma (BCC) frequently develop further tumors during follow-up.
  • METHODS: We used negative binomial regression analysis to study the association of selected variables on the rate of increase in BCC numbers in 266 Caucasian patients who first presented with a tumor on the head/neck or trunk with nodular or superficial histology.
  • RESULTS: Patients with an initial truncal BCC with superficial histology demonstrated significantly faster increases in BCC numbers than did patients with other site and histology combinations.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology. Ultraviolet Rays / adverse effects

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  • (PMID = 15761425.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Kaur P, Mulvaney M, Carlson JA: Basal cell carcinoma progression correlates with host immune response and stromal alterations: a histologic analysis. Am J Dermatopathol; 2006 Aug;28(4):293-307

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma progression correlates with host immune response and stromal alterations: a histologic analysis.
  • Basal cell carcinoma (BCC) can be subclassified into low- and high-risk types for local recurrence.
  • Superficial predominant BCC (major growth pattern) was significantly associated with trunk and extremity location (76%) and skin without solar elastosis (82%), whereas BCC harboring a nodular growth pattern component was significantly associated with a head and neck location (63%) and the presence of adjacent solar elastosis (all P< or =0.03).
  • [MeSH-major] Carcinoma, Basal Cell / immunology. Carcinoma, Basal Cell / pathology. Stromal Cells / immunology. Stromal Cells / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Shape. Disease Progression. Female. Humans. Inflammation / immunology. Inflammation / pathology. Male. Middle Aged. Risk Factors

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  • (PMID = 16871032.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Betti R, Radaelli G, Bombonato C, Crosti C, Cerri A, Menni S: Anatomic location of Basal cell carcinomas may favor certain histologic subtypes. J Cutan Med Surg; 2010 Nov-Dec;14(6):298-302
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  • [Title] Anatomic location of Basal cell carcinomas may favor certain histologic subtypes.
  • BACKGROUND: Differences in age, site, and subtype exist in basal cell carcinoma (BCC).
  • The location was the head/neck (n  =  1,766), limbs (n  =  362), trunk (n  =  1,113), or genitals (n  =  13).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 21084023.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Goh BK, Ang P, Wu YJ, Goh CL: Characteristics of basal cell carcinoma amongst Asians in Singapore and a comparison between completely and incompletely excised tumors. Int J Dermatol; 2006 May;45(5):561-4
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  • [Title] Characteristics of basal cell carcinoma amongst Asians in Singapore and a comparison between completely and incompletely excised tumors.
  • BACKGROUND: Most published series of basal cell carcinomas (BCCs) are based on Caucasian populations.
  • PATIENTS AND METHODS: A retrospective study was conducted using the case records of patients who had a primary BCC excised at the National Skin Centre between 1991 and 1995.
  • Incompletely excised BCCs were more likely than completely excised lesions to be located on the mid-face and trunk (P = 0.003), but there was no significant correlation with tumor size, tumor duration, or patient age, race, and gender.
  • Incomplete excision is associated with tumor location on the mid-face and trunk rather than tumor size or duration.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Neoplasm Recurrence, Local / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 16700792.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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21. Wu JK, Oh C, Strutton G, Siller G: An open-label, pilot study examining the efficacy of curettage followed by imiquimod 5% cream for the treatment of primary nodular basal cell carcinoma. Australas J Dermatol; 2006 Feb;47(1):46-8
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  • [Title] An open-label, pilot study examining the efficacy of curettage followed by imiquimod 5% cream for the treatment of primary nodular basal cell carcinoma.
  • SUMMARY The short-term efficacy of imiquimod 5% cream for the treatment of primary superficial basal cell carcinoma has been established.
  • This study investigated its efficacy following curettage (without electrodesiccation) for the treatment of primary nodular basal cell carcinoma on the trunk and limbs.
  • Curettage was used to de-bulk the lesion and confirm suitable histology.
  • Three months post treatment all lesions were excised, and 32 of 34 treated lesions (94%) were histologically clear of basal cell carcinoma.
  • Curettage followed by imiquimod 5% cream is effective for the treatment of primary nodular basal cell carcinoma on the trunk and limbs, and most patients are pleased with the cosmetic outcome.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Basal Cell / therapy. Skin Neoplasms / therapy

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  • (PMID = 16405483.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Emollients; 99011-02-6 / imiquimod
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22. Gross K, Kircik L, Kricorian G: 5% 5-Fluorouracil cream for the treatment of small superficial Basal cell carcinoma: efficacy, tolerability, cosmetic outcome, and patient satisfaction. Dermatol Surg; 2007 Apr;33(4):433-9; discussion 440
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  • [Title] 5% 5-Fluorouracil cream for the treatment of small superficial Basal cell carcinoma: efficacy, tolerability, cosmetic outcome, and patient satisfaction.
  • BACKGROUND: Five percent 5-fluorouracil (5-FU) cream is approved by the FDA for the treatment of superficial basal cell carcinomas but has been underutilized.
  • OBJECTIVE: The objective was to evaluate the efficacy, tolerability, cosmetic outcome, and patient satisfaction of 5% 5-FU in the treatment of superficial basal cell carcinomas.
  • MATERIALS AND METHODS: A total of 29 patients with 31 biopsy-proven superficial basal cell carcinoma lesions on the trunk or limbs were treated with 5% 5-FU cream twice daily for up to 12 weeks.
  • CONCLUSION: Five percent 5-FU is a highly effective and well-tolerated treatment option for superficial basal cell carcinomas offering a generally good cosmetic outcome and high levels of patient satisfaction.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Carcinoma, Basal Cell / drug therapy. Fluorouracil / administration & dosage. Skin Neoplasms / drug therapy


23. Rose RF, Merchant W, Stables GI, Lyon CL, Platt A: Basal cell carcinoma with a sarcomatous component (carcinosarcoma): a series of 5 cases and a review of the literature. J Am Acad Dermatol; 2008 Oct;59(4):627-32
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  • [Title] Basal cell carcinoma with a sarcomatous component (carcinosarcoma): a series of 5 cases and a review of the literature.
  • Four lesions occurred on the face and one on the trunk.
  • Each tumor had an epithelial component resembling a typical nodular basal cell carcinoma.
  • [MeSH-major] Carcinosarcoma / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 18793937.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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24. Scalvenzi M, Francia MG, Falleti J, Balato A: Basal cell carcinoma with fibroepithelioma-like histology in a healthy child: report and review of the literature. Pediatr Dermatol; 2008 May-Jun;25(3):359-63
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  • [Title] Basal cell carcinoma with fibroepithelioma-like histology in a healthy child: report and review of the literature.
  • We report the case of a 13-year-old girl with a 7 mm plaque on the trunk.
  • In 2003 a dermoscopic examination was executed and a diagnosis of dermical nevus was made.
  • On examination at our department, a red-pinkish plaque with two small areas of ulceration was found on the anterior part of the trunk.
  • A diagnosis of basal cell carcinoma was made and confirmed by histopathologic examination.
  • Basal cell carcinoma occurs rarely in children and is most often associated with an underlying condition that predisposes patients to the development of malignancy that was not present in our case.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Dermoscopy. Diagnosis, Differential. Female. Humans

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  • (PMID = 18577044.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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25. Yap FB: Clinical characteristics of basal cell carcinoma in a tertiary hospital in Sarawak, Malaysia. Int J Dermatol; 2010 Feb;49(2):176-9
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  • [Title] Clinical characteristics of basal cell carcinoma in a tertiary hospital in Sarawak, Malaysia.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer among Orientals.
  • Data on this malignancy is lacking in Malaysia, prompting a retrospective study to determine the clinical characteristics in the skin clinic, Sarawak General Hospital between 2000 and 2008.
  • There were 82.8% of BCC on the head and neck region and 17.2% on the trunk and limb region.
  • Additionally, BCC on the trunk and limbs and in men were larger, ulcerative and long standing warranting better efforts for earlier detection.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 20465642.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Richmond-Sinclair NM, Pandeya N, Williams GM, Neale RE, van der Pols JC, Green AC: Clinical signs of photodamage are associated with basal cell carcinoma multiplicity and site: a 16-year longitudinal study. Int J Cancer; 2010 Dec 1;127(11):2622-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical signs of photodamage are associated with basal cell carcinoma multiplicity and site: a 16-year longitudinal study.
  • Although sun exposure is known to be associated with basal cell carcinoma (BCC), it is not known what determines multiple occurrences of BCCs among sporadically affected individuals or why BCCs develop on uncommonly sun-exposed body sites like the trunk.
  • In a prospective community-based skin cancer study in Queensland, Australia, we studied all participants who experienced a histologically confirmed BCC from 1992 to 2007.
  • Male sex (OR = 2.5, 95% CI 1.5-5.3) and age 60 or over (OR = 4.2, 95% CI 1.5-11.8) but not skin type were associated with highest BCC counts among those affected.
  • Moreover, occurrences of BCC on the trunk (OR = 3.3, 95% CI 1.4-7.6) and on the limbs (OR = 3.7, 95% CI 2.0-7.0) were strongly associated with high numbers of solar keratoses on these sites, respectively.
  • Among those newly affected by BCC, chronic cutaneous sun damage predicts those who will be affected by more than 1 BCC, while chronic sun damage on the trunk and limbs predicts BCC occurrence on the trunk and limbs, respectively.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Neoplasms, Radiation-Induced / epidemiology. Skin Neoplasms / epidemiology. Sunlight / adverse effects
  • [MeSH-minor] Adult. Female. Humans. Longitudinal Studies. Male. Middle Aged. Queensland / epidemiology. Radiation Tolerance. Skin Pigmentation / physiology. Skin Pigmentation / radiation effects

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  • (PMID = 20196068.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Delfino S, Innocenzi D, Di Lorenzo G, Scalvenzi M, Montesarchio V, Feroce F, Baldi A, Persichetti P: An increase in basal cell carcinoma among the young: an epidemiological study in a middle-south Italian population. Anticancer Res; 2006 Nov-Dec;26(6C):4979-83
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  • [Title] An increase in basal cell carcinoma among the young: an epidemiological study in a middle-south Italian population.
  • During the last 20 years, an increasing incidence of basal cell carcinoma (BCC) has been demonstrated by several studies.
  • Anatomic site distribution of BCC among people aged <35 years was: head and neck=51.54%, trunk=41.40%, limbs=5.91%, others= 1.12%.
  • In conclusion, an increasing incidence of basal cell carcinoma among young people over the past 20 years was reported.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 17214374.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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28. Watson A, Kent P, Alam M, Paller AS, Umbach DM, Yoon JW, Iannaccone PM, Walterhouse DO: GLI1 genotypes do not predict basal cell carcinoma risk: a case control study. Mol Cancer; 2009 Nov 30;8:113
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  • [Title] GLI1 genotypes do not predict basal cell carcinoma risk: a case control study.
  • BACKGROUND: Susceptibility to basal cell carcinoma results from complex interactions between ultraviolet radiation exposure and genetic factors.
  • We determined whether GLI1 polymorphisms were risk factors for developing basal cell carcinoma, either alone or in combination with patterns of past sun exposure, and whether there were functional differences among different GLI1 haplotypes.
  • RESULTS: GLI1 genotypes at c.2798 and c.3298 from 201 basal cell carcinoma patients were compared to 201 age and sex-matched controls.
  • However, the odds of developing basal cell carcinoma on the trunk compared to the head/neck appeared somewhat lower with carriers of the c.3298GC than the CC genotype.
  • There was no evidence for interactions between skin type, childhood sunburning, average adult sun exposure, adult sunbathing, or intermittency of sun exposure and GLI1 haplotype.
  • Additionally, we found no significant differences in transcription activation or cell transforming ability among the four GLI1 haplotypes.
  • CONCLUSION: These results suggest that different GLI1 genotypes alone or in combination with past sun exposure patterns as assessed in this study do not affect basal cell carcinoma risk.

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  • (PMID = 19948058.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2789726
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29. Pelucchi C, Naldi L, Di Landro A, La Vecchia C, Oncology Study Group of Italian Group for Epidemiologic Research in Dermatology: Anthropometric measures, medical history and risk of basal cell carcinoma in an Italian case-control study. Dermatology; 2008;216(3):271-6
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  • [Title] Anthropometric measures, medical history and risk of basal cell carcinoma in an Italian case-control study.
  • BACKGROUND/AIMS: A few epidemiological studies investigated etiological factors for basal cell carcinoma (BCC) other than sunlight exposure and sunburns.
  • Corresponding estimates for trunk BCC were 0.42, 0.81, 0.50 and 0.47.
  • Subjects with asthma (OR = 0.26) and diabetes mellitus (OR = 0.23) showed a decreased risk of trunk BCC but not face and neck BCC.
  • CONCLUSION: The inverse relations between trunk, but not face and neck BCC, and obesity, diabetes mellitus and asthma may indirectly reflect the different role of past sunlight exposure to different body locations and variable etiologic pathways for BCCs according to body areas.
  • [MeSH-major] Body Weights and Measures. Carcinoma, Basal Cell / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 18196938.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Switzerland
  • [Investigator] Betti R; Inselvini E; Crosti C; Rossi E; Pini M; Galbiati G; Ceschini R; Simonacci M; Virgili A; Lombardi A; Braga D; Puiatti P; Bonvicino A; Lo Schiavo A; Fabbrocini G; Sarracco G; Barile M; Feliciangeli M; Barba A; Cattoni D; Pestelli F; Carli P; Cusano F; Adamo F; Sclamich S; Magaton Rizzi G; Filotico R
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30. Ahlgrimm-Siess V, Horn M, Koller S, Ludwig R, Gerger A, Hofmann-Wellenhof R: Monitoring efficacy of cryotherapy for superficial basal cell carcinomas with in vivo reflectance confocal microscopy: a preliminary study. J Dermatol Sci; 2009 Jan;53(1):60-4
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  • [Title] Monitoring efficacy of cryotherapy for superficial basal cell carcinomas with in vivo reflectance confocal microscopy: a preliminary study.
  • BACKGROUND: Superficial BCCs (sBCCs) usually appear as multiple lesions in chronic sun-damaged skin of elderly people and may show a destructive growth if left untreated.
  • Non-invasive treatment modalities, such as cryotherapy have been employed for sBCCs, all failing to provide tissue for confirming diagnosis and assessing adequacy of tumour removal.
  • Reflectance confocal microscopy (RCM), a new non-invasive imaging technique has proven to be a useful tool for detection of basal cell carcinoma in vivo.
  • METHODS: We examined 10 histologically proven sBCCs located on the trunk of 5 consecutive patients with a mean age of 84.6 years.
  • Five hours after cryotherapy, all 10 sBCCs showed small bright round to polygonal structures at basal layer and black round to oval areas of varying size with such bright structures floating therein, correlating to cell necrosis and incipient blistering.
  • Eight sBCCs showed also cell necrosis in upper dermis.
  • CONCLUSION: Early cell necrosis within upper dermal structures seems to correlate with ablation of overlying tumour tissue.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / therapy. Cryotherapy / methods. Microscopy, Confocal. Skin Neoplasms / pathology. Skin Neoplasms / therapy
  • [MeSH-minor] Aged, 80 and over. Biopsy. Female. Humans. Male. Necrosis. Skin / pathology. Time Factors. Treatment Outcome

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  • (PMID = 18829267.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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31. Betti R, Radaelli G, Mussino F, Menni S, Crosti C: Anatomic location and histopathologic subtype of basal cell carcinomas in adults younger than 40 or 90 and older: any difference? Dermatol Surg; 2009 Feb;35(2):201-6
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  • [Title] Anatomic location and histopathologic subtype of basal cell carcinomas in adults younger than 40 or 90 and older: any difference?
  • BACKGROUND: Differences in age, site, and histopathologic subtype exist in basal cell carcinoma (BCC).
  • The site was classified as head and neck, trunk, or limbs and the subtype as nodular, superficial, or morpheic-infiltrative.
  • RESULTS: Younger exhibited a lower prevalence of BCCs on the head and neck (36.0% vs 57.3%, p<.01) and a higher prevalence on the trunk (59.3% vs 31.5%, p<.01) and of superficial BCCs (43.0% vs 31.5%, p<.05) than older patients.
  • Superficial BCCs were mostly on the trunk (p<.001), with a higher prevalence in younger patients (86.5% vs 62.5%, p<.05).
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 19215256.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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32. Omari AK, Khammash MR, Matalka I: Skin cancer trends in northern Jordan. Int J Dermatol; 2006 Apr;45(4):384-8
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  • [Title] Skin cancer trends in northern Jordan.
  • BACKGROUND: The Jordan Cancer Registry was established in 1996, since which time all cases of cancer have been reported and registered.
  • We have used this registry to perform the first analysis of skin cancer in northern Jordan and to compare our findings with those of published reports from other regions.
  • METHODS: All histopathologically proven cases of skin cancer, reported during the years 1997 through 2001, were reviewed.
  • RESULTS: A total of 272 cases of malignant skin tumors were diagnosed between the years 1997 and 2001.
  • Basal cell carcinoma (BCC) was the commonest type, representing 52.9% of all skin cancers.
  • Squamous cell carcinoma (SCC) comprised 26.4% of the total, its age-adjusted incidence rate per 100,000 of population being 14.2 for males and 6.18 for females. the incidence rate increased in males and decreased in females during the study period.
  • The head and neck region was the commonest site affected by both types of cancer.
  • Malignant melanoma (MM) comprised 11.39% of all skin cancer cases, with a female to male ratio of 1.2 : 1.
  • The median age at onset for female patients was 49 years while that for males was 70 years, and the commonest site affected was the lower limbs, followed by the trunk.
  • CONCLUSIONS: In Jordan, sun-related skin cancers have relatively low incidences and a rather stable pattern, compared with other areas with similar climate and skin phenotypes.
  • [MeSH-major] Skin Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Female. Head and Neck Neoplasms / epidemiology. Humans. Jordan / epidemiology. Male. Melanoma / epidemiology. Middle Aged. Registries. Retrospective Studies. Sex Distribution

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  • (PMID = 16650163.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Schütt F, Staff C, Stein T, Hartschuh W, Dithmar S: [Photodynamic therapy of lid basal cell carcinomas in a 13-year-old patient with Gorlin Goltz syndrome]. Klin Monbl Augenheilkd; 2007 Aug;224(8):670-3
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  • [Title] [Photodynamic therapy of lid basal cell carcinomas in a 13-year-old patient with Gorlin Goltz syndrome].
  • BACKGROUND: Gorlin Goltz syndrome is a rare, autosomal dominant inherited disease that is characterised by multiple basal cell carcinomas (BCC) including the periorbital region and eye lids.
  • PATIENT: A 13-year-old boy with Gorlin Goltz syndrome presented with multiple confluent BCC on both eye lids and the skin of neck and trunk.
  • [MeSH-major] Basal Cell Nevus Syndrome / drug therapy. Basal Cell Nevus Syndrome / pathology. Carcinoma, Basal Cell / drug therapy. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / drug therapy. Eyelid Neoplasms / pathology. Photochemotherapy / methods

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  • (PMID = 17717785.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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34. Heal CF, Raasch BA, Buettner PG, Weedon D: Accuracy of clinical diagnosis of skin lesions. Br J Dermatol; 2008 Sep;159(3):661-8
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  • [Title] Accuracy of clinical diagnosis of skin lesions.
  • BACKGROUND: Skin cancer is an increasing problem in fair-skinned populations worldwide.
  • It is important that doctors are able to diagnose skin lesions accurately.
  • OBJECTIVES: To compare the clinical with the histological diagnosis of excised skin lesions from a set of epidemiological data.
  • We analysed diagnostic accuracy stratified by histological subtype and body site and examined the histological nature of misclassified diagnosis.
  • METHODS: All excised and histologically confirmed skin cancers in Townsville/Thuringowa, Australia from December 1996 to October 1999 were recorded.
  • RESULTS: Skin excisions in 8694 patients were examined.
  • PPVs for the clinical diagnoses were: basal cell carcinoma (BCC) 72.7%; squamous cell carcinoma (SCC) 49.4%; cutaneous melanoma (CM) 33.3%.
  • Sensitivities for the clinical diagnosis were: BCC 63.9%; SCC 41.1%; CM 33.8%.
  • For BCC, PPVs and sensitivities were higher for the trunk, the shoulders and the face and lower for the extremities.
  • Accuracy of diagnosis was dependent on body site.
  • [MeSH-major] Clinical Competence. Dermatology. Family Practice. Pathology, Clinical / standards. Skin Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Australia. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. False Negative Reactions. False Positive Reactions. Female. Humans. Male. Melanoma / diagnosis. Melanoma / pathology. Middle Aged. Nevus / diagnosis. Nevus / pathology. Nevus, Pigmented / diagnosis. Nevus, Pigmented / pathology. Predictive Value of Tests. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 18616767.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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35. Emanuel PO, Rudikoff D, Phelps RG: Aggressive squamous cell carcinoma in Kindler syndrome. Skinmed; 2006 Nov-Dec;5(6):305-7
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  • [Title] Aggressive squamous cell carcinoma in Kindler syndrome.
  • A 57-year-old Hispanic man with a personal and family history of bullae and photosensitivity presented with a fungating, ulcerated squamous cell carcinoma on his left hand (Figure 1).
  • There was reticulated erythema, atrophy, hyperpigmentation and hypopigmentation, and telangiectasia of sun-exposed skin of the face, neck, and hands consistent with poikiloderma (Figure 2).
  • Extensive histologic evaluation of the specimen obtained following left arm amputation and lymph node dissection showed moderate-to-poorly differentiated deeply invasive squamous cell carcinoma.
  • Two of 3 axillary lymph nodes were positive for metastatic carcinoma.
  • A random biopsy of the trunk showed epidermal atrophy, telangiectasia, a perivascular lymphocytic infiltration, and pigment-laden macrophages consistent with poikiloderma.
  • Electron microscopy illustrated extensive reduplication of the basement membrane, with loops, curls, and free extensions of the basal lamina in the superficial dermis; reduced numbers of hemidesmosomes and anchoring fibrils; and a basement membrane focally devoid of basal cells (Figure 4).
  • On the basis of the clinical features and the characteristic basement zone changes, a diagnosis of Kindler syndrome was made.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Epidermolysis Bullosa / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Hand / pathology. Humans. Male. Middle Aged. Syndrome


36. Bernard P, Dupuy A, Brun P, Sasko A, Duru G, Nicoloyannis N, Decuypere L, Grob JJ: [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists]. Ann Dermatol Venereol; 2007 Jun-Jul;134(6-7):527-33
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  • [Title] [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists].
  • [Transliterated title] Evaluation médico-économique de la prise en charge des carcinomes basocellulaires superficiels et des kératoses actiniques multiples par les dermatologues français.
  • INTRODUCTION: To date, no prospective studies have been conducted in France describing the management of actinic keratoses (AK) and superficial basal cell carcinomas (sBCC).
  • The therapeutic modalities, the physicians involved and the laboratory examinations during the 3 months following diagnosis were recorded prospectively.
  • RESULTS: 512 patients with sBCC (mean age: 69 years; sex-ratio M/F: 0.92) were included in the study. sBCC was isolated in 80% of cases, measured less than 2 cm in 90%, and was located on the head/neck in 51% and on the trunk in 37%.
  • Histological confirmation of diagnosis of BCC was obtained in 85% of cases.
  • AKs were located on the head/neck in 74% of cases and on the trunk in 6%.
  • [MeSH-major] Carcinoma, Basal Cell / economics. Carcinoma, Basal Cell / surgery. Health Care Costs. Photosensitivity Disorders / economics. Photosensitivity Disorders / therapy. Skin Neoplasms / economics. Skin Neoplasms / surgery

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  • (PMID = 17657178.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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37. Estrada JG: Non-melanoma skin cancer in Catalonia. A community-based prevalence study. Int J Dermatol; 2005 Nov;44(11):922-4
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  • [Title] Non-melanoma skin cancer in Catalonia. A community-based prevalence study.
  • INTRODUCTION: Accurate epidemiologic studies of non-melanoma skin cancer in South Europe are nearly absent.
  • MATERIALS AND METHODS: A population-based cohort of 1000 women was examined for skin cancer.
  • The sample was obtained from women attending a massive campaign of mammography addressing all women aged 50-65 years in the area of Sant Boi de Llobregat, Catalonia, Spain.
  • RESULTS: Nine cases of basal cell carcinoma were histologically confirmed, resulting in a prevalence of 900 cases in 10(5) (95% CI 601; 1198).
  • Five of them were located on the trunk, in non-exposed sites.
  • CONCLUSION: The prevalence of basal cell carcinoma found in our population is one of the highest reported in Europe.
  • A significant proportion of tumors are on the trunk, suggesting the existence of a high proportion of undetected cases.
  • Similar studies in 5-10-year intervals could aid detection of changing trends in the prevalence of skin cancer in our population.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 16336524.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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38. Neale RE, Forman D, Murphy MF, Whiteman DC: Site-specific occurrence of nonmelanoma skin cancers in patients with cutaneous melanoma. Br J Cancer; 2005 Sep 5;93(5):597-601
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  • [Title] Site-specific occurrence of nonmelanoma skin cancers in patients with cutaneous melanoma.
  • In a registry-based case-control study, we compared the site-specific occurrence of nonmelanoma (keratinocytic) skin cancers among patients with cutaneous melanoma cases (cases, n = 3774) and solid tumours (controls, n = 349,923), respectively.
  • Whereas patients with melanoma of the head and neck had similarly increased risks of keratinocytic cancers across all body sites, patients with melanoma of the trunk were significantly more likely to develop keratinocyte cancer diagnosed on the trunk (adjusted OR 12.5, 95% CI 7.2-20.2) than on the head and neck (adjusted OR 3.0, 95% CI 2.2-4.3).
  • Similar colocalisation of skin tumours was observed for patients with melanomas of the lower limb.
  • These findings provide support for the hypothesis that skin cancers at different anatomical sites may arise through different causal pathways.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Melanoma / complications. Skin Neoplasms / complications. Skin Neoplasms / epidemiology

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  • (PMID = 16106265.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2361604
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39. Cohen PR, Martinelli PT, Schulze KE, Nelson BR: The cuticular purse string suture: a modified purse string suture for the partial closure of round postoperative wounds. Int J Dermatol; 2007 Jul;46(7):746-53
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  • BACKGROUND: The purse string suture can be used to provide primary closure for small skin defects or as a partial closure for larger round wounds.
  • The size of the defect is reduced secondary to the tension placed on the suture, which uniformly advances the skin from the entire periphery of the wound.
  • RESULTS: Postoperative wounds were created following Mohs' micrographic excision of nonmelanoma skin cancer (basal cell carcinoma, 44; squamous cell carcinoma, 25), wide local excision of melanoma (29), or conservative excision of benign cutaneous neoplasms (two).
  • The incidence of purse string suture for partial closure of each tumor was 4.1% for basal cell carcinoma, 7.3% for squamous cell carcinoma, and 46.3% for melanoma.
  • The tumors were equally distributed on the trunk, head and neck, and extremities; however, purse string closures for basal cell carcinomas were more frequent on the trunk, head, and neck, relative to squamous cell carcinomas and melanomas, which were more common on the extremities.
  • CONCLUSION: The cuticular purse string suture is a rapid and simple procedure that provides complete or partial closure of round skin defects and excellent long-term cosmetic and functional results.
  • The purse string suture is also useful following nonmelanoma skin cancer removal in patients who insist on maintaining an active lifestyle in the immediate postoperative period, who are receiving one or more systemic anticoagulant and/or antiplatelet agents, and who have large surgical wounds that would require either a skin graft or a local cutaneous flap in order to close the postoperative defect.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Melanoma / surgery. Skin Neoplasms / surgery. Suture Techniques

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  • (PMID = 17614809.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Cho KJ, Lee DH, Kim NG, Kim J: Fibroepithelioma of pinkus on mucocutaneous junction. J Craniofac Surg; 2010 Nov;21(6):1991-3
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  • Fibroepithelioma of Pinkus is a variant form of basal cell carcinoma that clinically presents as a single or multiple red plaques or flesh-colored nodules without ulceration.
  • It is usually located in the trunk, inguinal, or crural areas and only rarely occurs on the mucocutaneous junction.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Nasal Mucosa / pathology. Nose Neoplasms / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 21119480.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Vun Y, De'Ambrosis B, Spelman L, Muir JB, Yong-Gee S, Wagner G, Lun K: Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation? Australas J Dermatol; 2006 May;47(2):106-8

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  • A retrospective study of 813 histological specimens reported as seborrhoeic keratoses included 43 (5.3%) associated with non-melanoma skin cancer.
  • Intraepidermal carcinoma (squamous cell carcinoma in situ) was the most common of these (36).
  • There were five basal cell carcinomas (one with intraepidermal carcinoma also) and two invasive squamous cell carcinomas.
  • Twenty-seven of the intraepidermal carcinomas appeared to arise within the seborrhoeic keratosis as did one of the invasive squamous cell carcinomas.
  • Fourteen were clinically diagnosed as a non-melanoma skin cancer with only nine clinically felt to be a seborrhoeic keratosis.
  • Twelve specimens reported adjacent dual pathologies, with the trunk and limbs the most common sites.
  • Seven were diagnosed clinically as a skin malignancy, whereas three were thought to be solar keratoses.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Cell Transformation, Neoplastic. Female. Head. Humans. Male. Medical Records. Middle Aged. Precancerous Conditions. Queensland / epidemiology. Retrospective Studies. Skin Neoplasms / epidemiology. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16637805.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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42. Bozkurt M, Kapi E, Kuvat SV, Ozekinci S: Current concepts in the management of Marjolin's ulcers: outcomes from a standardized treatment protocol in 16 cases. J Burn Care Res; 2010 Sep-Oct;31(5):776-80
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  • Marjolin's ulcer is a malignant lesion observed in chronic wounds and in areas where the integrity of the skin is compromised because of any one of several reasons.
  • Primary lesions were at the leg, gluteal region, thigh, scalp, trunk, and hand in four (25%), three (18.7%), two (12.5%), two (12.5%), three (18.7%), and two (12.5%) cases, respectively.
  • Amputation was carried out to treat two cases, and repair of the defects with partial-thickness skin grafting was performed in 14 cases after tumor resection on the skin.
  • Squamous cell carcinoma was diagnosed in 14 cases (87.5%) and basal cell carcinoma in two cases (12.5%) postoperatively.
  • The authors conclude that diagnosis and surgical planning based on the recent literature must be carried out even more intensively to improve the prognosis of Marjolin's ulcer.
  • [MeSH-major] Burns / complications. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / surgery. Skin Neoplasms / etiology. Skin Neoplasms / surgery. Skin Ulcer / etiology. Skin Ulcer / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Amputation. Female. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Recurrence, Local. Skin Transplantation. Treatment Outcome

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  • (PMID = 20661151.001).
  • [ISSN] 1559-0488
  • [Journal-full-title] Journal of burn care & research : official publication of the American Burn Association
  • [ISO-abbreviation] J Burn Care Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Bowen AR, LeBoit PE: Fibroepithelioma of pinkus is a fenestrated trichoblastoma. Am J Dermatopathol; 2005 Apr;27(2):149-54
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  • Pinkus described "pre-malignant fibroepithelioma" as a proliferation that gave rise to many tiny basal cell carcinomas within each lesion.
  • Later authors have generally considered it to be an unusual variant of basal cell carcinoma (BCC).
  • Unlike the common types of BCC, FEP has an overwhelming predilection for the trunk and extremities, and only 5% of tumors are set in a dermis with significant amounts of solar elastosis.
  • Next, FEP, BCC, and FEP with BCC-like areas were stained with MIB-1 (to assess proliferation), p53 (an oncogene product), and CK20 (a Merkel cell marker) antisera.
  • [MeSH-major] Carcinoma, Basal Cell / classification. Hair Diseases / pathology. Neoplasms, Fibroepithelial / classification. Neoplasms, Fibroepithelial / pathology. Skin Neoplasms / classification

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  • (PMID = 15798442.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. King R, Page RN, Googe PB, Mihm MC Jr: Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous nevus. Mod Pathol; 2005 Oct;18(10):1397-401
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  • The anatomical sites included trunk (7), head and neck (6) and upper extremity (3).
  • The clinical diagnosis was variable and included lentigo maligna, atypical nevus, pigmented basal cell carcinoma, seborrheic keratosis and lentigo.
  • The diagnosis of melanoma was more easily recognized in the complete excision specimens.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Hutchinson's Melanotic Freckle / diagnosis. Lentigo / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15976811.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Yus ES, del Cerro M, Simón RS, Herrera M, Rueda M: Unna's and Miescher's nevi: two different types of intradermal nevus: hypothesis concerning their histogenesis. Am J Dermatopathol; 2007 Apr;29(2):141-51
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  • Eighty- three per cent of the nevi from the head and neck were intradermal nevi, whereas on the trunk and limbs junction and compound nevi were the most frequent (56%).
  • In contradistinction, 87% of the Unna's nevi located on the neck, trunk, and limbs, and 96% of intradermal nevi from these locations were Unna's nevi.
  • Miescher's nevi had more: pilosebaceous follicles within the nevus (100% versus 51%), subnevis folliculitis (12% versus 1%), large isolated melanocytes along the basal epidermal layer (47% versus 11%), multinucleated nevocytes (89% versus 44%), and adipocytes within the nevus (53% versus 11%).
  • [MeSH-major] Nevus, Intradermal / pathology. Nevus, Pigmented / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Child. Diagnosis, Differential. Female. Fibroma / pathology. Humans. Male. Melanoma / pathology. Middle Aged

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  • (PMID = 17414435.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Barcelos AC, Nico MM: Bazex-Dupré-Christol syndrome in a 1-year-old boy and his mother. Pediatr Dermatol; 2008 Jan-Feb;25(1):112-3
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  • Bazex-Dupré-Christol syndrome is a rare genodermatosis with cancer predisposition, characterized by follicular atrophoderma, multiple milia, congenital hypotrichosis, hypohidrosis and basal cell malformations that include nevoid basal cell carcinomas of early onset.
  • We present two patients with this syndrome, a 1-year-old boy with diffuse scalp and eyebrows alopecia, milia papules on the face, ears, trunk, and limbs.
  • Hypohidrosis was observed on his trunk and head.
  • She also had a basal cell carcinoma on her face.
  • [MeSH-major] Basal Cell Nevus Syndrome / genetics. Carcinoma, Basal Cell / pathology. Heterozygote. Precancerous Conditions / pathology. Skin Neoplasms / genetics
  • [MeSH-minor] Acrodermatitis / diagnosis. Acrodermatitis / genetics. Adolescent. Cell Transformation, Neoplastic. Female. Humans. Hypohidrosis / diagnosis. Hypohidrosis / genetics. Hypotrichosis / diagnosis. Hypotrichosis / genetics. Infant. Male. Mothers. Pedigree. Prognosis. Syndrome

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  • (PMID = 18304168.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Fumal I, Piérard-Franchimont C, Piérard GE: [Arsenical keratoses and carcinomas]. Rev Med Liege; 2005 Apr;60(4):217-21
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  • Within a few months, the patient developed multiple large superficial basal cell carcinomas on the trunk and several invasive squamous cell carcinomas.
  • A pulmonary cancer with cerebral metastases was also identified.
  • The recognition of the cutaneous warning signs allows to focus on the overall cancer risk of these patients.
  • [MeSH-major] Arsenic / adverse effects. Carcinoma, Basal Cell / chemically induced. Carcinoma, Squamous Cell / chemically induced. Keratosis / chemically induced. Skin Neoplasms / chemically induced

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  • (PMID = 15943097.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] N712M78A8G / Arsenic
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48. Alessi SS, Sanches JA, Oliveira WR, Messina MC, Pimentel ER, Festa Neto C: Treatment of cutaneous tumors with topical 5% imiquimod cream. Clinics (Sao Paulo); 2009;64(10):961-6
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  • MATERIALS AND METHODS: Here, we present our experience in the treatment of 123 cutaneous tumors of various types, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Bowen's disease, erythroplasia of Queyrat, Paget's disease, and trichoepithelioma, with 5% imiquimod cream from 2003 to 2008 in the Cutaneous Oncology Group of the Dermatology Department of Hospital das Clinicas.
  • Patients were divided into two separate groups according to their diagnosis and comorbidities; these comorbidities included epidermodysplasia verruciformis, xeroderma pigmentosum, albinism, basal cell nevus syndrome, Brooke-Spiegler syndrome, HIV, chronic lymphocytic leukemia, B-cell lymphoma, and kidney transplantation.
  • Tumors were located mainly on the face, back, trunk, and legs.
  • [MeSH-major] Adjuvants, Immunologic / administration & dosage. Aminoquinolines / administration & dosage. Antineoplastic Agents / administration & dosage. Skin Neoplasms / drug therapy

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  • [Cites] J Am Acad Dermatol. 1999 Dec;41(6):1002-7 [10570388.001]
  • [Cites] J Am Acad Dermatol. 2001 May;44(5):807-13 [11312429.001]
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  • (PMID = 19841702.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
  • [Other-IDs] NLM/ PMC2763070
  • [Keywords] NOTNLM ; Basal cell carcinoma / Imiquimod / Immunomodulator / Immunotherapy / Non-melanoma skin cancer
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49. Arco G, Horch RE, Arkudas A, Dragu A, Bach AD, Kneser U: Double pedicled perforator flap to close flank defects: an alternative for closure of a large lumbar defect after basalioma excision--a case report and review of the literature. Ann Plast Surg; 2009 Oct;63(4):422-4
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  • Large defects following resection of skin cancers are sometimes a challenge for the reconstructive surgeon.
  • Although skin grafts are considered as the first choice for reconstruction of large skin defects at the trunk region, pedicled or free flaps provide sometimes a superior functional and aesthetic outcome.
  • The skin defect after excision was reconstructed using a novel concept based on 2 independent pedicled perforator flaps, a lumbar artery perforator, and a lateral intercostal artery perforator.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Follow-Up Studies. Graft Survival. Humans. Lumbosacral Region. Male. Middle Aged. Skin Transplantation / methods. Tissue Expansion / methods. Tissue and Organ Harvesting. Treatment Outcome. Wound Healing / physiology

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  • (PMID = 19745707.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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50. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • [Title] Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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51. Ono I, Akasaka Y, Kikuchi R, Sakemoto A, Kamiya T, Yamashita T, Jimbow K: Basic fibroblast growth factor reduces scar formation in acute incisional wounds. Wound Repair Regen; 2007 Sep-Oct;15(5):617-23
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  • In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation.
  • Sutured wounds after excision of skin tumors from the face, trunk, and limbs and sutured wounds such as those at the donor sites of full-thickness skin grafts were treated with low-dose bFGF injections (0.1 microg/cm wound; Group 2), high-dose bFGF injections (1 microg/cm wound; Group 3), and rinsed with high-dose bFGF (1 microg/cm wound; Group 4).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / surgery. Child. Child, Preschool. Cicatrix, Hypertrophic / physiopathology. Female. Humans. Male. Middle Aged. Neoplasms, Squamous Cell / surgery. Skin Neoplasms / surgery. Suture Techniques

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  • (PMID = 17971006.001).
  • [ISSN] 1067-1927
  • [Journal-full-title] Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • [ISO-abbreviation] Wound Repair Regen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 103107-01-3 / Fibroblast Growth Factor 2
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52. Ko CJ, Barr RJ, Subtil A, McNiff JM: Acantholytic dyskeratotic acanthoma: a variant of a benign keratosis. J Cutan Pathol; 2008 Mar;35(3):298-301
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  • Lesions were most often found on the trunk as a solitary papule, for which the clinical diagnosis was often basal cell carcinoma.
  • [MeSH-major] Acantholysis / pathology. Acanthoma / pathology. Keratosis / pathology. Skin Neoplasms / pathology

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  • (PMID = 18251744.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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53. Samaila MO, Mbibu HN, Oluwole OP: Human mycetoma. Surg Infect (Larchmt); 2007 Oct;8(5):519-22
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  • However, the disease may present without these characteristic features, thus causing diagnostic difficulty with other chronic granulomatous infections such as tuberculosis or benign skin lesions.
  • Clinical presentation included pigmented cutaneous nodules, depigmented spots, multiple discharging sinuses, or a fungating mass with bone erosion, involving almost any part of the body (face, trunk, and leg).
  • The range of clinical misdiagnoses included skin tuberculosis, fibroma, amelanotic melanoma, basal-cell carcinoma, and brain tumor.
  • The presentation and clinical course may be confused with those of many skin diseases.
  • Knowledge of mycetoma pathology is important for prompt diagnosis and treatment of this indolent clinical entity.
  • [MeSH-major] Mycetoma / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 17999585.001).
  • [ISSN] 1096-2964
  • [Journal-full-title] Surgical infections
  • [ISO-abbreviation] Surg Infect (Larchmt)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Adams BB, Blatnoy V: Multiple erythematous plaques of the trunk. Am Fam Physician; 2005 Jul 1;72(1):143-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple erythematous plaques of the trunk.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Erythema / etiology. Neoplasms, Second Primary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Diagnostic Errors. Hodgkin Disease / radiotherapy. Humans. Male. Middle Aged. Physical Examination. Psoriasis / diagnosis. Radiotherapy / adverse effects. Risk Factors

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  • (PMID = 16035695.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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