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1. Bogdanov-Berezovsky A, Rosenberg L, Cagniano E, Silberstein E: The role of frozen section histological analysis in the treatment of head and neck skin basal and squamous cell carcinomas. Isr Med Assoc J; 2008 May;10(5):344-5
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  • [Title] The role of frozen section histological analysis in the treatment of head and neck skin basal and squamous cell carcinomas.
  • BACKGROUND: Skin basal and squamous cell carcinomas together account for over half of all newly diagnosed cancer cases.
  • Frozen section control of surgical margins is often required in the head and neck region.
  • METHODS: This was a retrospective study of 169 cutaneous basal and squamous cell carcinomas excised with surgical margins diagnosed by frozen section and confirmed by permanent paraffin sections.
  • The data included patients' age, gender, clinical and histopathological diagnosis, as well as characteristics of the lesions.
  • RESULTS: There were 149 (88%) basal cell carcinomas and 20 (12%) squamous cell carcinomas.
  • We did not find any correlation between false positive or false negative margins and patients' age, gender, tumor size, tumor location, or the presence of sun-damaged skin.
  • CONCLUSIONS: Our findings support the use of frozen section margin control in selected patients suffering from non-melanoma skin cancer of the head and neck.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Frozen Sections. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 18605355.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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2. Tarallo M, Cigna E, Frati R, Delfino S, Innocenzi D, Fama U, Corbianco A, Scuderi N: Metatypical basal cell carcinoma: a clinical review. J Exp Clin Cancer Res; 2008;27:65
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  • [Title] Metatypical basal cell carcinoma: a clinical review.
  • BACKGROUND: Metatypical cell carcinoma can be considered as a new entity of skin cancer, being an intermediate typology between basal cell carcinomas and squamous cell carcinomas.
  • The behaviour of the metatypical cell carcinoma lies between these two varieties of skin cancer.
  • It is difficult to perform a differential diagnosis based on morphological and clinical features - therefore it is only possible by accurate histology.
  • METHODS: The authors have retrospectively analysed clinical records of 240 patients who were affected by metatypical skin cancer and who were treated by surgery, radiotherapy and chemotherapy.
  • A recurrence occurred in 24 cases (10%), mainly in head and neck area.
  • CONCLUSION: In this manuscript, the authors have emphasised the importance of conducting a differential diagnosis, and the importance of the specific treatment for metatypical skin cancer, even though more clinical studies and long-term follow-ups are required before establishing specific guidelines.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 18992138.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 55
  • [Other-IDs] NLM/ PMC2585560
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3. Karen JK, Gareau DS, Dusza SW, Tudisco M, Rajadhyaksha M, Nehal KS: Detection of basal cell carcinomas in Mohs excisions with fluorescence confocal mosaicing microscopy. Br J Dermatol; 2009 Jun;160(6):1242-50
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  • [Title] Detection of basal cell carcinomas in Mohs excisions with fluorescence confocal mosaicing microscopy.
  • BACKGROUND: High-resolution real-time imaging of human skin is possible with a confocal microscope either in vivo or in freshly excised tissue ex vivo.
  • OBJECTIVES: To evaluate the sensitivity and specificity of ex vivo real-time imaging with fluorescence confocal mosaicing microscopy, using acridine orange, for the detection of residual basal cell carcinoma (BCC) in Mohs fresh tissue excisions.
  • METHODS: Forty-eight discarded skin excisions were collected following completion of Mohs surgery, consisting of excisions with and without residual BCC of all major subtypes.
  • Very good correlation was observed between confocal mosaics and matched Mohs frozen sections for benign and malignant skin structures, overall tumour burden and location, and identification of all major histological subtypes of BCC.
  • This observation is an important step towards the long-term clinical goal of using a noninvasive imaging modality for potential real-time surgical pathology-at-the-bedside for skin and other tissues.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Mohs Surgery / methods. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Microscopy, Confocal / methods. Microscopy, Fluorescence / methods. Sensitivity and Specificity

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  • (PMID = 19416248.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA008748; United States / NIBIB NIH HHS / EB / R01 EB002715; United States / NIBIB NIH HHS / EB / R01 EB002715-05; United States / NIBIB NIH HHS / EB / R01EB002715
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS95359; NLM/ PMC2693082
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4. Morselli P, Zollino I, Pinto V, Brunelli G, Carinci F: Evaluation of clinical prognostic factors in T1 N0 M0 head and neck basal cell carcinoma. J Craniofac Surg; 2009 Jan;20(1):98-100
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  • [Title] Evaluation of clinical prognostic factors in T1 N0 M0 head and neck basal cell carcinoma.
  • This retrospective study was carried out to assess the clinical outcome of stage I (ie, T1 N0 M0) head and neck basal cell carcinoma (HNBCC) and verify the impact of some clinical parameters on prognosis.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery

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  • (PMID = 19165001.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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5. Levi F, Randimbison L, Te VC, Conconi MM, La Vecchia C: Risk of prostate, breast and colorectal cancer after skin cancer diagnosis. Int J Cancer; 2008 Dec 15;123(12):2899-901
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  • [Title] Risk of prostate, breast and colorectal cancer after skin cancer diagnosis.
  • Ultraviolet radiation is the major cause of skin cancer, but promotes vitamin D synthesis, and vitamin D has been inversely related to the risk of several common cancers including prostate, breast and colorectum.
  • We therefore computed the incidence of prostate, breast and colorectal cancer following skin cancer using the datasets of the Swiss cancer Registries of Vaud and Neuchâtel.
  • Between 1974 and 2005, 6,985 histologically confirmed squamous cell skin cancers, 21,046 basal cell carcinomas and 3,346 cutaneous malignant melanomas were registered, and followed up to the end of 2005 for the occurrence of second primary cancer of the prostate, breast and colorectum.
  • When basal cell, squamous cell and skin melanoma were considered separately, all the SIRs for prostate, breast and colorectal cancers were around or slightly above unity.
  • Likewise, the results were consistent across strata of age at skin cancer diagnosis and location (head and neck versus others), and for male and female colorectal cancers.
  • These findings, based on a population with a long tradition of systematic histologic examination of all surgically treated skin lesions, do not support the hypothesis that prostate, breast and colorectal cancer risk is decreased following skin cancer.
  • [MeSH-major] Breast Neoplasms / epidemiology. Colorectal Neoplasms / epidemiology. Prostatic Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Ultraviolet Rays. Vitamin D / blood
  • [MeSH-minor] Adult. Aged. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Female. Humans. Incidence. Male. Melanoma / epidemiology. Middle Aged. Odds Ratio. Registries. Risk Assessment. Risk Factors. Switzerland / epidemiology


6. Kyrgidis A, Vahtsevanos K, Tzellos TG, Xirou P, Kitikidou K, Antoniades K, Zouboulis CC, Triaridis S: Clinical, histological and demographic predictors for recurrence and second primary tumours of head and neck basal cell carcinoma. A 1062 patient-cohort study from a tertiary cancer referral hospital. Eur J Dermatol; 2010 May-Jun;20(3):276-82
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  • [Title] Clinical, histological and demographic predictors for recurrence and second primary tumours of head and neck basal cell carcinoma. A 1062 patient-cohort study from a tertiary cancer referral hospital.
  • Basal cell carcinoma (BCC) accounts for nearly 25% of all cancers in the human body and for almost 75% of skin malignancies; approximately 85% of basal cell carcinomas develop in the head and neck region.
  • Our objective was to identify predictors of recurrence and second primary tumour development of BCC in the head and neck region.
  • We included 1062 patients with a histologically confirmed diagnosis of BCC.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / pathology. Hospitals, Special. Neoplasm Recurrence, Local / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 20406722.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
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7. Hoang MP, Dresser KA, Kapur P, High WA, Mahalingam M: Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol; 2008 Feb;21(2):178-85
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  • [Title] Microcystic adnexal carcinoma: an immunohistochemical reappraisal.
  • Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain.
  • In addition, a comparison with squamous cell carcinoma has not been reported previously.
  • In this study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell carcinoma, and eight squamous cell carcinoma of which five exhibited ductal differentiation.
  • We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative.
  • Forty percent of infiltrative basal cell carcinoma expressed CK7; while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories.
  • While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases.
  • Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10.
  • BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma.
  • In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation.
  • Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15+ and BerEP4+/-; thus, additional studies are needed to separate these two entities.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Skin Appendage / chemistry. Head and Neck Neoplasms / chemistry. Immunohistochemistry / methods. Skin Neoplasms / chemistry
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Humans. Keratin-15 / analysis. Male. Middle Aged

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  • (PMID = 18065959.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-15; 0 / human epithelial antigen-125
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8. Balasundram S, Kovilpillai FJ, Hopper C: Nevoid basal cell carcinoma syndrome presenting with neck pits and café au lait patches. J Clin Pediatr Dent; 2010;35(1):95-100
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  • [Title] Nevoid basal cell carcinoma syndrome presenting with neck pits and café au lait patches.
  • RESULTS: Clinical examination also revealed macrocephaly, fronto-parietal bossing, pitting on palmar and plantar surfaces, calcification of falx cerebri and splayed ribs, confirming the diagnosis of nevoid basal cell carcinoma syndrome.
  • He also presented with a cafi au lait patch and skin pits on the neck.
  • The family history was negative for features of nevoid basal cell carcinoma syndrome.
  • CONCLUSION: Nevoid basal cell carcinoma syndrome is a condition that can cause significant morbidity if not detected early.
  • [MeSH-major] Basal Cell Nevus Syndrome / diagnosis. Cafe-au-Lait Spots / diagnosis. Neck / pathology. Skin Abnormalities / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Mandibular Diseases / diagnosis. Maxillary Diseases / diagnosis. Odontogenic Cysts / diagnosis. Recurrence. Ribs / abnormalities

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  • (PMID = 21189772.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Fukunaga M: Cutaneous spindle cell carcinoma following basal cell carcinoma. Am J Dermatopathol; 2005 Feb;27(1):17-20
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  • [Title] Cutaneous spindle cell carcinoma following basal cell carcinoma.
  • A spindle cell carcinoma arose three years after the seeming excision of a so-called "infiltrative" basal cell carcinoma (IBCC) in the cheek of an 87-year-old Japanese woman.
  • The patient died after a local recurrence with metastatic lesions in the lung and the neck lymph nodes that were indicated by CT scanning and MRI at nine months after diagnosis.
  • This case and others support the concept that spindle cell carcinoma can pursue an aggressive clinical course.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Basal Cell / pathology. Neoplasms, Second Primary. Skin Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2005 Dec;27(6):546; author reply 546 [16314711.001]
  • (PMID = 15677971.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins
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10. Kaviani A, Ataie-Fashtami L, Fateh M, Sheikhbahaee N, Ghodsi M, Zand N, Djavid GE: Photodynamic therapy of head and neck basal cell carcinoma according to different clinicopathologic features. Lasers Surg Med; 2005 Jun;36(5):377-82
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  • [Title] Photodynamic therapy of head and neck basal cell carcinoma according to different clinicopathologic features.
  • BACKGROUND AND OBJECTIVES: We aimed to treat different pathologic types of basal cell carcinomas (BCCs) using photodynamic therapy (PDT).
  • RESULTS: After a single session of PDT, the average response rate in different histopathologic kinds of basal cell carcinoma (e.g., ulcerative, superficial, nodular, and pigmented forms) were 100%, 62%, 90%, and 14%, respectively.
  • [MeSH-major] Carcinoma, Basal Cell / drug therapy. Head and Neck Neoplasms / drug therapy. Hematoporphyrin Derivative / therapeutic use. Hematoporphyrin Photoradiation. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15965991.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 68335-15-9 / Hematoporphyrin Derivative
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11. Tschen JP, Cohen PR, Schulze KE, Tschen JA, Nelson BR: Pleomorphic basal cell carcinoma: case reports and review. South Med J; 2006 Mar;99(3):296-302
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  • [Title] Pleomorphic basal cell carcinoma: case reports and review.
  • Pleomorphic basal cell carcinoma is a pathologic variant of basal cell carcinoma characterized by the presence of atypical-appearing, mononuclear or multinucleated giant cells.
  • Including our 3 patients, a total of 52 pleomorphic basal cell carcinomas have been described in 48 individuals.
  • The tumors usually present as a nodule on the head or neck.
  • The nuclei of the giant tumor cells are irregularly shaped, hyperchromatic, and 2 to 10 times larger than the nuclei of the surrounding cancer cells.
  • The pathogenesis of pleomorphic basal cell carcinoma remains to be determined; however, investigations utilizing electron microscopy, immunohistochemistry, image analysis, and flow cytometry have provided additional insight regarding the features of the giant tumor cells and the etiology of this cancer.
  • Although these aneuploid tumors have alarming microscopic features, their clinical course is similar to that of basal cell carcinomas without pleomorphic giant tumor cells.
  • Our patients' pleomorphic basal cell carcinomas were successfully treated by excision using the Mohs micrographic surgical technique.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Dermis / ultrastructure. Diagnosis, Differential. Female. Humans. Male. Microscopy, Electron

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  • (PMID = 16553108.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Naumann IC, Cordes SR: Giant basal cell carcinoma of the forehead with extensive intracranial involvement. Ann Otol Rhinol Laryngol; 2007 Sep;116(9):663-6
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  • [Title] Giant basal cell carcinoma of the forehead with extensive intracranial involvement.
  • Basal cell carcinoma (BCC) is the most common malignant skin lesion and is frequently curatively treated with local excision.
  • Improper removal or neglect of BCC is a particular problem for head and neck surgeons.
  • We describe a case of a recurrent BCC that aggressively grew from the forehead skin through the skull and into the frontal lobe.
  • Despite its fairly benign growth pattern, BCC should never be underestimated, and care should be taken not only in the complete primary excision but also in cancer surveillance.
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Forehead. Head and Neck Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnostic imaging. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures / methods. Reconstructive Surgical Procedures / methods. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 17926588.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Bechert CJ, Stern JB: Basal cell carcinoma with perineural invasion: reexcision perineural invasion? J Cutan Pathol; 2010 Mar;37(3):376-9
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  • [Title] Basal cell carcinoma with perineural invasion: reexcision perineural invasion?
  • BACKGROUND: Perineural invasion (PI) in basal cell and squamous cell carcinomas, especially of the head and neck, has been reported to indicate an increased morbidity.
  • Reexcision perineural invasion (RPI), a benign mimic of tumoral perineural invasion, may present a difficult histologic differential diagnosis.
  • METHODS: We surveyed the medical literature for PI occurring in basal cell carcinomas to investigate the degree to which the reported cases occurred in reexcision specimens vs. primary biopsy specimens.
  • RESULTS: We found large retrospective studies of 14,120 basal cell carcinomas evaluated for PI in which 310 cases of PI were identified (2.2%), and 20 sporadic case reports of basal cell carcinomas with PI.
  • Of 310 cases of basal cell carcinoma with PI, 196 (63%) were in reexcision specimens.
  • CONCLUSION: The high percentage of PI occurring in reexcision specimens vs. primary excisions may indicate that many of the reported cases of basal cell carcinomas with PI are actually examples of RPI.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasm Invasiveness / pathology. Neoplasm Seeding. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Humans. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies

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  • [CommentIn] J Cutan Pathol. 2011 Jan;38(1):76-7 [20840330.001]
  • [CommentIn] J Cutan Pathol. 2012 Nov;39(11):1047-8 [22830947.001]
  • [CommentIn] J Cutan Pathol. 2011 Jan;38(1):78-9 [20860728.001]
  • (PMID = 19615028.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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14. Tiftikcioğlu YO, Karaaslan O, Aksoy HM, Aksoy B, Koçer U: Basal cell carcinoma in Turkey. J Dermatol; 2005 Dec;32(12):946-50
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  • [Title] Basal cell carcinoma in Turkey.
  • Basal cell carcinoma (BCC) is the most common form of cancer in Caucasians.
  • The age and sex distribution, personal and family histories of the patients, skin type, sites and sizes of the lesions, clinical types of the lesions, status of the surgical margins, and incidences of recurrence were analyzed.
  • Of the tumors, 91.5% occurred on the head and neck.
  • There were also personal and/or family histories of cancer in 24.8% of our cases.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / epidemiology. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology

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  • (PMID = 16471455.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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15. Gudi V, Ormerod AD, Dawn G, Green C, MacKie RM, Douglas WS, Gupta G, Scottish Dermatological Society: Management of basal cell carcinoma by surveyed dermatologists in Scotland. Clin Exp Dermatol; 2006 Sep;31(5):648-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of basal cell carcinoma by surveyed dermatologists in Scotland.
  • BACKGROUND: The British Association of Dermatologists (BAD) has produced guidelines for management of basal cell carcinoma (BCC) in the UK.
  • A diagnostic biopsy was taken in 22% of lesions, and the rest were treated definitively after a clinical diagnosis of BCC, of which 90% were confirmed on histology.
  • Nodulocystic lesions were the most common type of tumour, comprising 48% of lesions, and most BCCs were located on the head and neck region.
  • [MeSH-major] Carcinoma, Basal Cell. Skin Neoplasms

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  • (PMID = 16901303.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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16. Boswell JS, Flam MS, Tashjian DN, Tschang TP: Basal cell carcinoma metastatic to cervical lymph nodes and lungs. Dermatol Online J; 2006;12(6):9
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  • [Title] Basal cell carcinoma metastatic to cervical lymph nodes and lungs.
  • Metastatic basal cell carcinoma (MBCC) of the skin is rare in occurrence and may initially elude proper diagnosis and management.
  • We describe a case of MBCC to cervical lymph nodes, originally evaluated and treated surgically as metastatic thyroid carcinoma.
  • After definitive diagnosis of MBCC was made, chemotherapy and concomitant radiation treatment were initiated; however, despite these measures, the patient then developed MBCC to the lung.
  • In addition to the more commonly metastasizing carcinomas, metastases from a cutaneous basal cell carcinoma primary tumor should be considered when evaluating cervical lymph node metastases of an uncertain head and neck primary.
  • [MeSH-major] Carcinoma, Basal Cell / secondary. Carcinoma, Papillary / diagnosis. Diagnostic Errors. Head and Neck Neoplasms / diagnosis. Lung Neoplasms / secondary. Lymphatic Metastasis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle. Carboplatin / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Second Primary. Radiotherapy. Seminoma. Skin Neoplasms / surgery. Taxoids / administration & dosage. Testicular Neoplasms. Thyroidectomy. Unnecessary Procedures

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  • (PMID = 17083889.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids; 0W860991D6 / Deoxycytidine; 15H5577CQD / docetaxel; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
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17. Asuquo ME, Agweye P, Ugare G, Ebughe G: Basal cell carcinoma in five albino Africans from the south-eastern equatorial rain forest of Nigeria. Int J Dermatol; 2007 Jul;46(7):754-6
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  • [Title] Basal cell carcinoma in five albino Africans from the south-eastern equatorial rain forest of Nigeria.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the white population and occurs infrequently in dark-pigmented individuals.
  • Albinism is an established risk factor for skin cancer in black Africans.
  • METHODS: We evaluated the clinical histories and treatment outcomes of patients with a histologic diagnosis of BCC, who were seen at the University of Calabar Teaching Hospital, Calabar, Nigeria between January 2000 and December 2004.
  • The five patients ranged in age from 21 to 60 years (mean, 38 years); six BCCs (67%) were located in the head and neck area, and three tumors (33%) involved the upper limbs.
  • [MeSH-major] Albinism / complications. Carcinoma, Basal Cell / etiology. Skin Neoplasms / etiology. Ultraviolet Rays / adverse effects

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  • (PMID = 17614810.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Azzam C, Arrese JE, Jacquemin D, Calteux N, Piérard GE: [Pedunculated and pigmented basal cell carcinoma: an unusual presentation]. Rev Med Liege; 2006 Sep;61(9):614-6
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  • [Title] [Pedunculated and pigmented basal cell carcinoma: an unusual presentation].
  • Basal cell carcinomas (BCC) are the most common malignant neoplasms in humans.
  • It is important to be aware of the different clinical presentations both for the accurate diagnosis and tumour management.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17112160.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Belgium
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19. Shumaker PR, Lane K, Harford R: Linear unilateral basal cell nevus: a benign follicular hamartoma simulating multiple basal cell carcinomas. Cutis; 2006 Aug;78(2):122-4
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  • [Title] Linear unilateral basal cell nevus: a benign follicular hamartoma simulating multiple basal cell carcinomas.
  • We report a case of linear unilateral basal cell nevus (LBCN) occurring on the left lateral neck and left posterior shoulder of a 23-year-old woman.
  • LBCN is a rare benign follicular hamartoma that must be distinguished from the more aggressive unilateral and segmental variant of nevoid basal cell carcinoma syndrome (NBCCS) and the linear variant of BCC.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Hamartoma / pathology. Nevus / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 16983901.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Bogdanić B, Smud S, Bagatin D, Nola M, Mijatović D, Majerović M: Giant basal cell carcinoma of the back: a case report and review of the literature. Coll Antropol; 2009 Mar;33(1):315-8
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  • [Title] Giant basal cell carcinoma of the back: a case report and review of the literature.
  • Basal cell carcinoma (BCC) is the most common cutaneous malignancy and the most common human malignancy in general.
  • Out of all basal cell carcinomas, giant basal cell carcinoma represents less than 1%.
  • Only 10% of all basal cell carcinomas are located on the trunk and majority is located on the head and neck.
  • We describe a patient with a exophytic giant basal cell carcinoma of the back size 8.5 x 8 x 6 cm, infiltrating skin 1.5 cm.
  • Two years after the lesion has occurred, diagnosis was made by pathohistological analysis.
  • Review of the literature that refers to giant basal cell carcinoma was carried out.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 19408644.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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21. Li N, Wolgamot G, Argenyi Z: Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma. J Cutan Pathol; 2007 May;34(5):410-4
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  • [Title] Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma.
  • Although primary cutaneous neuroendocrine cell carcinoma [Merkel cell carcinoma (MCC)] may show divergent features, including microcystic ('tubuloglandular'), squamous, eccrine and rhabdomyoblastic, a diffuse microcystic pattern is exceedingly rare.
  • In this study, we present two cases of MCC with prominent microcystic features, which precluded a definitive diagnosis in the initial punch biopsy.
  • Both patients were middle-aged men with a history of rapidly growing plaques of the back or posterior neck.
  • Although the lack of CK20 staining is unusual, the histologic characteristics along with the remaining immunohistochemical studies favor the diagnosis of a primary cutaneous neuroendocrine cell carcinoma over the variants of eccrine carcinoma or basal cell carcinoma with neuroendocrine differentiation.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Eccrine Glands / pathology. Humans. Immunohistochemistry. Male. Neck / pathology

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  • (PMID = 17448197.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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22. Sarfati B, Lazar CC, Goubin I, Zwillinger N, Lorenceau B: [Basal-cell carcinoma of fingers: a rare location not to be ignored]. Ann Chir Plast Esthet; 2010 Feb;55(1):74-7
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  • [Title] [Basal-cell carcinoma of fingers: a rare location not to be ignored].
  • The basal-cell carcinoma is the most frequent malignant tumor in human, usually involving the healthy sun-exposed skin of head and neck area, but thoracic and members localisations are possible.
  • Periungual lesions are in this context very rare and we report the case of a 64-year-old man presenting with a basal-cell carcinoma on the thumb.
  • A literature review was also performed and our purpose is to warn our colleagues about this quite often unrecognized pathology which may need a more aggressive treatment in case of delayed diagnosis, and to remind them that all chronic lesions impose a biopsy.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Fingers / pathology. Fingers / surgery. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • [Copyright] 2008 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19223107.001).
  • [ISSN] 1768-319X
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. Lehnerdt G, Manz D, Jahnke K, Schmitz KJ: [Cutaneous basosquamous cell carcinoma]. HNO; 2008 Mar;56(3):306-11
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  • [Title] [Cutaneous basosquamous cell carcinoma].
  • BACKGROUND: Basosquamous carcinoma (BSC) is a rare malignancy with specific histopathological features of both basal cell (BCC) and squamous cell carcinoma (SCC).
  • Therefore, the histological diagnosis is challenging.
  • One patient was treated by partial removal of the auricle with superficial parotidectomy and ipsilateral neck dissection.
  • In the case of the carcinoma on the forehead, a local excision was performed.
  • CONCLUSIONS: The histological diagnosis of BSC is confirmed by the use of EMA and BerEP4 immunohistological staining.
  • Clinically, BSC is a rare, aggressive skin tumor.
  • Despite the histological similarity to basal cell carcinoma, BSC has an imminent risk of metastasizing.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Basosquamous / surgery. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods. Skin Neoplasms / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome


24. Eggers G, Flechtenmacher C, Kurzen H, Hassfeld S: Infiltrating basal cell carcinoma of the neck 34 years after irradiation of an haemangioma in early childhood. A case-report. J Craniomaxillofac Surg; 2005 Jun;33(3):197-200
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  • [Title] Infiltrating basal cell carcinoma of the neck 34 years after irradiation of an haemangioma in early childhood. A case-report.
  • A case of a 34-year-old Caucasian male is presented with a basal cell carcinoma deeply infiltrating the structures of the neck, including skeletal muscles and reaching the parotid gland.
  • Thirty years ago the patient had undergone radiotherapy for an infantile haemangioma of the skin of the neck.
  • The effects of this treatment when given in childhood in the aetiology of a basal cell carcinoma are discussed.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Head and Neck Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology
  • [MeSH-minor] Adult. Hemangioma / radiotherapy. Humans. Male. Skin Neoplasms / radiotherapy. Time Factors

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  • (PMID = 15878521.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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25. Betz CS, Rauschning W, Stranadko EP, Riabov MV, Albrecht V, Nifantiev NE, Hopper C: Optimization of treatment parameters for Foscan-PDT of basal cell carcinomas. Lasers Surg Med; 2008 Jul;40(5):300-11
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  • [Title] Optimization of treatment parameters for Foscan-PDT of basal cell carcinomas.
  • BACKGROUND AND OBJECTIVE: Basal cell carcinomas (BCCs) are the most common form of skin cancers with high and increasing incidence rates.
  • STUDY DESIGN/MATERIALS AND METHODS: mTHPC-PDT was performed in 117 patients with a total of 460 BCCs with diagnosis confirmed by scratch cytology.
  • [MeSH-major] Carcinoma, Basal Cell / drug therapy. Head and Neck Neoplasms / drug therapy. Mesoporphyrins / therapeutic use. Photochemotherapy. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 18563776.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mesoporphyrins; 0 / Photosensitizing Agents; FU21S769PF / temoporfin
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26. Plaza JA, Ortega PF, Bengana C, Stockman DL, Suster S: Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases. Am J Dermatopathol; 2010 Oct;32(7):683-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases.
  • When the morphologic distinction between basal cell carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two neoplasms from each other.
  • Their distinction is clinically important because the risk of progressive disease in BCC can be problematic, and trichoepitheliomas misinterpreted as BCC burdens the patient with an inaccurate diagnosis and consequential inappropriate surgery.
  • Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous neoplasms, such as adnexal tumors, squamous cell carcinomas, etc.
  • Of the 27 cases of BCC, 18 cases were located in the head and neck area, 5 on upper extremities, and 4 on the back.
  • Of the 22 cases of trichoepitheliomas, all were from the head and neck area.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Membrane Glycoproteins / biosynthesis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antibodies, Monoclonal. Antibodies, Monoclonal, Murine-Derived. Diagnosis, Differential. Humans. Immunohistochemistry. Predictive Value of Tests

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  • (PMID = 20559122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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27. Murchie P, Delaney EK, Thompson WD, Lee AJ: Excising basal cell carcinomas: comparing the performance of general practitioners, hospital skin specialists and other hospital specialists. Clin Exp Dermatol; 2008 Aug;33(5):565-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Excising basal cell carcinomas: comparing the performance of general practitioners, hospital skin specialists and other hospital specialists.
  • BACKGROUND: General practitioners (GPs) are not encouraged to excise basal cell carcinomas (BCCs).
  • GPs may be able to have a greater role in the diagnosis and management of BCC, but much needs to be learnt before this can be advocated.
  • OBJECTIVE: To compare the practice of GPs, skin specialists (dermatologists and plastic surgeons) and other hospital specialists in excising BCCs.
  • RESULTS: GPs perform significantly less well than skin specialists when diagnosing and excising BCCs, but appear equal in diagnostic skill and better at excision than other hospital specialists.
  • CONCLUSIONS: GPs compare unfavourably with skin specialists in diagnosing and excising BCCs.
  • There is considerable room to optimize current GP performance, particularly with lesions of the head and neck, and it may be that novel approaches to GP training are required to achieve this.
  • Structured request forms may improve the quality of clinical information provided when skin biopsies are submitted for pathological examination.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Clinical Competence / standards. Dermatology. Physicians, Family. Skin Neoplasms / surgery

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  • (PMID = 18355357.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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28. Tamiolakis D, Proimos E, Perogamvrakis GE, Skoulakis CE, Georgiou GC, Papadakis CE: Brushing cytology in cutaneous lesions of the head and neck. J Laryngol Otol; 2007 Jul;121(7):676-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brushing cytology in cutaneous lesions of the head and neck.
  • Our aim was to evaluate its reliability in ulcerative and tumour-like conditions arising in the skin of the head and neck.
  • RESULTS: Cytological analysis identified 63 out of 64 histologically documented malignant tumours (60 primary basal cell and squamous cell carcinomas and three metastatic adenocarcinomas), and 21 out of 22 benign lesions.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cytological Techniques. Diagnosis, Differential. Endometriosis / pathology. False Negative Reactions. False Positive Reactions. Female. Humans. Sensitivity and Specificity

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  • (PMID = 17403275.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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29. Dadzie OE, Goerig R, Bhawan J: Incidental microscopic foci of nevic aggregates in skin. Am J Dermatopathol; 2008 Feb;30(1):45-50
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  • [Title] Incidental microscopic foci of nevic aggregates in skin.
  • Incidental nevic aggregates were typically dermal in nature and found commonly in excisions from the head and neck region.
  • The nevic aggregates were separate and located in normal skin, away from any associated tumors or scar tissue.
  • [MeSH-major] Incidental Findings. Melanocytes / pathology. Nevus / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Male. Melanoma / pathology. Middle Aged. Retrospective Studies

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  • [CommentIn] Am J Dermatopathol. 2008 Aug;30(4):403-6 [18645318.001]
  • (PMID = 18212544.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Ntomouchtsis A, Vahtsevanos K, Patrikidou A, Andreadis C, Tsobanidou C, Antoniades K: Adnexal skin carcinomas of the face. J Craniofac Surg; 2009 Jan;20(1):134-7
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  • [Title] Adnexal skin carcinomas of the face.
  • Skin adnexal neoplasms are rare tumors, and knowledge on their exact histological development and pathogenesis remains fragmented.
  • Their diagnosis and management are frequently troublesome, especially for malignant tumors.
  • Records of patients with histologically confirmed adnexal skin carcinoma managed at a single department during the period 1995 to 2004 were reviewed.
  • Two patients showed regional metastasis and underwent radical neck dissection.
  • Clinical and histological features, tumor biological behavior, diagnostic difficulties, and recommended management are discussed.In conclusion, adnexal skin tumors should be considered in the differential diagnosis of skin tumors, particularly in view of their more sinister prognosis compared with other nonmelanoma skin tumors.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Facial Neoplasms / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Cohort Studies. Diagnosis, Differential. Disease-Free Survival. Eyelid Neoplasms / surgery. Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local / pathology. Neoplasms, Second Primary / pathology. Nose Neoplasms / surgery. Retrospective Studies. Surgical Flaps. Survival Rate. Treatment Outcome

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  • (PMID = 19165010.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Fischer S, Breuninger H, Metzler G, Hoffmann J: Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg; 2005 Jan;16(1):53-8
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  • [Title] Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor.
  • Microcystic adnexal carcinoma (MAC) belongs to the spectrum of locally aggressive adnexal carcinomas and most commonly occurs in the head and neck region.
  • The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time.
  • Previous histopathologic diagnoses were squamous cell carcinoma and desmoplastic trichoepithelioma.
  • The reported case demonstrates the difficulties in diagnosing MAC and indicates that MAC should always be considered in the differential diagnosis of slowly growing tumors in the head and neck region.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Basal Cell / pathology

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  • (PMID = 15699645.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. de Vries E, Soerjomataram I, Houterman S, Louwman MW, Coebergh JW: Decreased risk of prostate cancer after skin cancer diagnosis: a protective role of ultraviolet radiation? Am J Epidemiol; 2007 Apr 15;165(8):966-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decreased risk of prostate cancer after skin cancer diagnosis: a protective role of ultraviolet radiation?
  • Ultraviolet radiation causes skin cancer but may protect against prostate cancer.
  • The authors hypothesized that skin cancer patients had a lower prostate cancer incidence than the general population.
  • In the southeastern part of the Netherlands, a population-based cohort of male skin cancer patients diagnosed since 1970 (2,620 squamous cell carcinomas, 9,501 basal cell carcinomas, and 1,420 cutaneous malignant melanomas) was followed up for incidence of invasive prostate cancer until January 1, 2005, within the framework of the Eindhoven Cancer Registry.
  • The incidence rates of prostate cancer among skin cancer patients were compared with those in the reference population, resulting in standardized incidence ratios.
  • Skin cancer patients were at decreased risk of developing prostate cancer compared with the general population (standardized incidence ratio (SIR) = 0.89, 95% confidence interval (CI): 0.78, 0.99), especially shortly after diagnosis.
  • The risk of advanced prostate cancer was significantly decreased (SIR = 0.73, 95% CI: 0.56, 0.94), indicating a possible antiprogression effect of ultraviolet radiation.
  • Patients with a skin cancer in the chronically ultraviolet radiation-exposed head and neck area (SIR = 0.84, 95% CI: 0.73, 0.97) and those diagnosed after the age of 60 years (SIR = 0.86, 95% CI: 0.75, 0.97) had decreased prostate cancer incidence rates.
  • These results support the hypothesis that ultraviolet radiation protects against prostate cancer.
  • [MeSH-major] Head and Neck Neoplasms / epidemiology. Prostatic Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Ultraviolet Rays
  • [MeSH-minor] Age Factors. Aged. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Humans. Incidence. Male. Melanoma / epidemiology. Middle Aged. Prostate / pathology. Risk Factors. Time Factors


33. Bernard P, Dupuy A, Brun P, Sasko A, Duru G, Nicoloyannis N, Decuypere L, Grob JJ: [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists]. Ann Dermatol Venereol; 2007 Jun-Jul;134(6-7):527-33
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  • [Title] [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists].
  • [Transliterated title] Evaluation médico-économique de la prise en charge des carcinomes basocellulaires superficiels et des kératoses actiniques multiples par les dermatologues français.
  • INTRODUCTION: To date, no prospective studies have been conducted in France describing the management of actinic keratoses (AK) and superficial basal cell carcinomas (sBCC).
  • The therapeutic modalities, the physicians involved and the laboratory examinations during the 3 months following diagnosis were recorded prospectively.
  • RESULTS: 512 patients with sBCC (mean age: 69 years; sex-ratio M/F: 0.92) were included in the study. sBCC was isolated in 80% of cases, measured less than 2 cm in 90%, and was located on the head/neck in 51% and on the trunk in 37%.
  • Histological confirmation of diagnosis of BCC was obtained in 85% of cases.
  • AKs were located on the head/neck in 74% of cases and on the trunk in 6%.
  • [MeSH-major] Carcinoma, Basal Cell / economics. Carcinoma, Basal Cell / surgery. Health Care Costs. Photosensitivity Disorders / economics. Photosensitivity Disorders / therapy. Skin Neoplasms / economics. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Cost-Benefit Analysis. Cryotherapy / economics. Female. France. Head. Humans. Male. Neck. Photochemotherapy / economics. Practice Guidelines as Topic. Prospective Studies. Sunlight / adverse effects. Surveys and Questionnaires. Thorax

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  • (PMID = 17657178.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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34. Suciu V, Botan E, Valent A, Chami L, Spatz A, Vielh P: The potential contribution of fluorescent in situ hybridization analysis to the cytopathological diagnosis of Merkel cell carcinoma. Cytopathology; 2008 Feb;19(1):48-51
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  • [Title] The potential contribution of fluorescent in situ hybridization analysis to the cytopathological diagnosis of Merkel cell carcinoma.
  • We report the cases of two patients with head and neck Merkel cell carcinoma (MCC) who developed local recurrences confirmed by cytopathology.
  • [MeSH-major] Carcinoma, Merkel Cell / genetics. In Situ Hybridization, Fluorescence. Neoplasm Recurrence, Local / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Fine-Needle. Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Chromosomes, Human, Pair 6 / genetics. Chromosomes, Human, Pair 8 / genetics. Female. Humans. Immunohistochemistry. Male. Neoplasms, Second Primary / genetics. Neoplasms, Second Primary / pathology. Trisomy

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  • (PMID = 18205628.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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35. Emanuel PO, Rudikoff D, Phelps RG: Aggressive squamous cell carcinoma in Kindler syndrome. Skinmed; 2006 Nov-Dec;5(6):305-7
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  • [Title] Aggressive squamous cell carcinoma in Kindler syndrome.
  • A 57-year-old Hispanic man with a personal and family history of bullae and photosensitivity presented with a fungating, ulcerated squamous cell carcinoma on his left hand (Figure 1).
  • There was reticulated erythema, atrophy, hyperpigmentation and hypopigmentation, and telangiectasia of sun-exposed skin of the face, neck, and hands consistent with poikiloderma (Figure 2).
  • Extensive histologic evaluation of the specimen obtained following left arm amputation and lymph node dissection showed moderate-to-poorly differentiated deeply invasive squamous cell carcinoma.
  • Two of 3 axillary lymph nodes were positive for metastatic carcinoma.
  • Electron microscopy illustrated extensive reduplication of the basement membrane, with loops, curls, and free extensions of the basal lamina in the superficial dermis; reduced numbers of hemidesmosomes and anchoring fibrils; and a basement membrane focally devoid of basal cells (Figure 4).
  • On the basis of the clinical features and the characteristic basement zone changes, a diagnosis of Kindler syndrome was made.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Epidermolysis Bullosa / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Hand / pathology. Humans. Male. Middle Aged. Syndrome


36. Brewster DH, Bhatti LA, Inglis JH, Nairn ER, Doherty VR: Recent trends in incidence of nonmelanoma skin cancers in the East of Scotland, 1992-2003. Br J Dermatol; 2007 Jun;156(6):1295-300
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  • [Title] Recent trends in incidence of nonmelanoma skin cancers in the East of Scotland, 1992-2003.
  • BACKGROUND: Historically, ascertainment of nonmelanoma skin cancer (NMSC) by cancer registries in the U.K. has been shown to be incomplete in several studies.
  • However, recent evidence suggesting that almost all clinically diagnosed NMSCs are verified histologically, coupled with the increasing availability of electronic histopathology data to cancer registries, raises the possibility that this situation may have improved.
  • OBJECTIVES: To assess recent trends in incidence of the main types of NMSC and carcinoma in situ (CIS) of the skin in Scotland.
  • METHODS: The study was restricted to selected health board areas in the East of Scotland for which pathology data have been used routinely to support cancer registration since the early 1990s.
  • Incident cases of squamous cell carcinoma (SCC) of the skin, CIS of the skin, and first ever basal cell carcinoma (BCC) were extracted from the Scottish Cancer Registry covering the period of diagnosis 1992-2003.
  • Sex-specific, age-standardized and age-specific incidence rates were calculated for four consecutive 3-year periods of diagnosis.
  • The percentage distribution of SCC, BCC and CIS of the skin by anatomical site and sex was calculated for the period of diagnosis 1997-2003.
  • Age-adjusted rates of SCC, first ever BCC, and CIS of the skin have all increased significantly in both sexes between 1992 and 2003 (all P < 0.001), with EAPCs ranging in magnitude from +1.4% (first ever BCC in males) to +5.1% (CIS in males).
  • The majority of lesions arose on the head and neck area, with the exception of CIS, which in females was more commonly located on the limbs.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 17535229.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Wei CC, Sanfilippo NJ, Myssiorek D: Re-irradiation of metastatic disease in the neck from xeroderma pigmentosum. Curr Oncol; 2010 Jun;17(3):83-5
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  • [Title] Re-irradiation of metastatic disease in the neck from xeroderma pigmentosum.
  • Mutation of these enzymes leads to the development of multiple basal cell and squamous cell carcinomas.
  • OBJECTIVES: We present a case of xeroderma pigmentosum in a patient with cervical and intraparotid metastatic disease from recurrent cutaneous squamous cell carcinomas of the face and scalp, treated with neck dissection and re-irradiation.
  • With the illustrative case report, we include a literature review of diagnosis, prognostic factors, and treatment, with emphasis on surgical and radiation treatment of cervical metastatic disease from recurrent skin carcinomas.
  • CASE PRESENTATION: A xeroderma pigmentosum patient presented to our clinic with a 2-cm right submental and 1-cm right infra-auricular mass after resection of multiple squamous cell carcinomas of the scalp and face, and external-beam radiation therapy to the right face and neck.
  • Fine-needle aspiration biopsy of the submental mass revealed poorly differentiated squamous cell carcinoma.
  • The patient was brought to the operating room for a right modified radical neck dissection and excision of the right submental and intraparotid mass.
  • Surgical pathology revealed 3 level ia and supraclavicular lymph nodes that were positive for metastatic squamous cell carcinoma.
  • Re-irradiation to the entire right hemi-neck and left submandibular nodal region was performed using opposed oblique portals for the upper neck and a low anterior en face hemi-neck portal.
  • CONCLUSIONS: To our knowledge, this is the first case report in the literature of a patient with xeroderma pigmentosum who subsequently developed metastatic disease from recurrent cutaneous squamous cell carcinoma.

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  • [Cites] J Cutan Med Surg. 1998 Jan;2(3):153-8 [9479081.001]
  • [Cites] Radiother Oncol. 2000 Nov;57(2):143-54 [11054518.001]
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  • [Cites] Br J Radiol. 2006 Jun;79(942):510-7 [16714754.001]
  • (PMID = 20567629.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2880910
  • [Keywords] NOTNLM ; Xeroderma pigmentosum / head-and-neck cancer / radiation / re-irradiation
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38. Nieto Enriquez J, Medel Jiménez R, Huguet Redecilla P: Undiagnosed squamous cell carcinoma of the forehead presenting as a Tolosa-Hunt syndrome. Orbit; 2009;28(5):290-2
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  • [Title] Undiagnosed squamous cell carcinoma of the forehead presenting as a Tolosa-Hunt syndrome.
  • Squamous cell carcinoma (SCC) is the second most common periocular skin cancer.
  • We describe a case of invasive squamous cell carcinoma arising from actinic keratosis and causing orbital and intracranial invasion via perineural spread.
  • Perineural invasion (PNI) is a known feature of SCC and very rarely basal cell carcinomas of the head and neck.
  • [MeSH-major] Brain Neoplasms / diagnosis. Carcinoma, Squamous Cell / diagnosis. Skin Neoplasms / diagnosis. Tolosa-Hunt Syndrome / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Fatal Outcome. Female. Forehead. Humans. Keratosis, Actinic / complications. Neoplasm Invasiveness


39. Castori M, Castiglia D, Passarelli F, Paradisi M: Bazex-Dupré-Christol syndrome: an ectodermal dysplasia with skin appendage neoplasms. Eur J Med Genet; 2009 Jul-Aug;52(4):250-5
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  • [Title] Bazex-Dupré-Christol syndrome: an ectodermal dysplasia with skin appendage neoplasms.
  • Bazex-Dupré-Christol syndrome is a rare X-linked genodermatosis characterized by early-onset nonmelanoma skin cancers, atrophoderma follicularis, hypotrichosis, hypohidrosis, and multiple milia.
  • We report a 5-year-old child presenting sparse hair, reduced sweating, ice-pick skin depressions of the dorsum of hands, facial and limb milia, perianal skin hyperpigmentation, and hyperpigmented papules of the axillae and neck.
  • Histologic examination of a skin papule obtained from the index case revealed features consistent with trichoepithelioma.
  • Our findings indicate that trichoepitheliomas are an early sign of Bazex-Dupré-Christol syndrome and may guide the diagnosis even before the development of basal cell carcinomas.
  • The high frequency of hypotrichosis, hypohidrosis and dry skin in Bazex-Dupré-Christol syndrome indicates that it may be better classified as an ectodermal dysplasia.
  • Comparison with other conditions combining features of ectodermal dysplasia and proneness to skin tumors suggests the involvement of a common pathogenic pathway implicated in both skin development and cancer.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Carcinoma, Basal Cell / pathology. Ectodermal Dysplasia / genetics. Skin Neoplasms / genetics. Skin Neoplasms / pathology
  • [MeSH-minor] Child, Preschool. Hair / pathology. Humans. Hyperpigmentation / diagnosis. Hyperpigmentation / pathology. Hypohidrosis / diagnosis. Hypohidrosis / physiopathology. Hypotrichosis / diagnosis. Hypotrichosis / pathology. Male

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  • (PMID = 19138767.001).
  • [ISSN] 1878-0849
  • [Journal-full-title] European journal of medical genetics
  • [ISO-abbreviation] Eur J Med Genet
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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40. Rieger KE, Linos E, Egbert BM, Swetter SM: Recurrence rates associated with incompletely excised low-risk nonmelanoma skin cancer. J Cutan Pathol; 2010 Jan;37(1):59-67
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  • [Title] Recurrence rates associated with incompletely excised low-risk nonmelanoma skin cancer.
  • BACKGROUND: Reported recurrence rates for transected nonmelanoma skin cancer (NMSC) vary widely, and few studies have addressed recurrence of tumors followed clinically or treated with nonsurgical modalities.
  • METHODS: Retrospective review of dermatopathology records from January 1999 to January 2005 was conducted to identify biopsies or excision specimens with histologically transected basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) which were not subsequently excised.
  • Multivariate logistic regression identified three significant predictors of recurrence: tumor location on the head and neck (p = 0.041), tumor size (p = 0.00741) and superficial subtype of BCC (p = .035).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Neoplasm Recurrence, Local / diagnosis. Skin Neoplasms / pathology

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  • [Copyright] Copyright © 2009 John Wiley & Sons A/S.
  • (PMID = 19615009.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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41. Soerjomataram I, Louwman WJ, Lemmens VE, Coebergh JW, de Vries E: Are patients with skin cancer at lower risk of developing colorectal or breast cancer? Am J Epidemiol; 2008 Jun 15;167(12):1421-9
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  • [Title] Are patients with skin cancer at lower risk of developing colorectal or breast cancer?
  • Ultraviolet exposure may reduce the risk of colorectal and breast cancer as the result of rising vitamin D levels.
  • Because skin cancer is positively related to sun exposure, the authors hypothesized a lower incidence of breast and colorectal cancer after skin cancer diagnosis.
  • They analyzed the incidence of colorectal and breast cancer diagnosed from 1972 to 2002 among 26,916 Netherlands skin cancer patients (4,089 squamous cell carcinoma (SCC), 19,319 basal cell carcinoma (BCC), and 3,508 cutaneous malignant melanoma (CMM)).
  • A markedly decreased risk of colorectal cancer was found for subgroups supposedly associated with the highest accumulated sun exposure: men (standardized incidence ratio (SIR) = 0.83, 95% confidence interval (CI): 0.71, 0.97); patients with SCC (SIR = 0.64, 95% CI: 0.43, 0.93); older patients at SCC diagnosis (SIR = 0.59, 95% CI: 0.37, 0.88); and patients with a SCC or BCC lesion on the head and neck area (SIR = 0.59, 95% CI: 0.36, 0.92 for SCC and SIR = 0.78, 95% CI: 0.63, 0.97 for BCC).
  • Patients with CMM exhibited an increased risk of breast cancer, especially advanced breast cancer (SIR = 2.20, 95% CI: 1.10, 3.94) and older patients at CMM diagnosis (SIR = 1.87, 95% CI: 1.14, 2.89).
  • Study results suggest a beneficial effect of continuous sun exposure against colorectal cancer.
  • The higher risk of breast cancer among CMM patients may be related to socioeconomic class, both being more common in the affluent group.
  • [MeSH-major] Breast Neoplasms / epidemiology. Colorectal Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Ultraviolet Rays. Vitamin D / blood
  • [MeSH-minor] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Confidence Intervals. Female. Humans. Incidence. Male. Melanoma / epidemiology. Middle Aged. Netherlands / epidemiology. Odds Ratio. Risk Assessment. Risk Factors


42. Liutkeviciūte-Navickiene J, Mordas A, Simkute S, Bloznelyte-Plesniene L: [Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester]. Medicina (Kaunas); 2009;45(12):937-42
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  • [Title] [Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
  • OBJECTIVE: The incidence of malignant skin tumors is rapidly increasing.
  • Early diagnosis, determining the margins of the tumor, is extremely important to achieve good treatment results.
  • We investigated fluorescence of protoporphyrin IX in skin carcinomas.
  • The study aimed to compare the effectiveness of topical 5-aminolevulinic acid and methyl-aminolevulinate in determining the exact margins of skin tumors.
  • MATERIALS AND METHODS: Fluorescence measurements were performed in 126 patients with malignant, premalignant, and benign skin lesions for detection of the margins of squamous cell carcinoma and basal cell carcinoma.
  • 5-Aminolevulinic acid or its methyl ester was applied to the skin lesion for 2-4 h, and the data of evaluated protoporphyrin IX fluorescence were correlated with the data of morphological tissue examination.
  • RESULTS: Malignant tissue shows a specific red fluorescence when illuminated with blue-violet light, whereas no fluorescence was observed in normal skin.
  • CONCLUSIONS: Fluorescence diagnostics can be used for complete visualization of malignant skin lesions after topical application of 5-aminolevulinic acid or methyl aminolevulinate.
  • It has been shown to be highly effective in the diagnostics of malignant superficial skin lesion.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Fluorescence. Head and Neck Neoplasms / diagnosis. Photosensitizing Agents. Precancerous Conditions / diagnosis. Protoporphyrins. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Esters. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Sensitivity and Specificity. Skin / pathology

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  • (PMID = 20173396.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Lithuania
  • [Chemical-registry-number] 0 / Esters; 0 / Photosensitizing Agents; 0 / Protoporphyrins; 0 / methyl 5-aminolevulinate; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
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43. Fontaine J, Mielczarek S, Meaume S, Senet P: [Incidence of undiagnosed skin cancers in a geriatric hospital]. Ann Dermatol Venereol; 2008 Oct;135(10):651-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Incidence of undiagnosed skin cancers in a geriatric hospital].
  • BACKGROUND: The incidence of non melanoma skin cancers is closely correlated with age.
  • The aim of this prospective study was to evaluate the prevalence of undiagnosed skin cancers among patients hospitalized in rehabilitation and long-term care units in a geriatric hospital.
  • Clinical data included patient age at the time of the study, gender, relevant historical information, skin phototype and description of the cutaneous lesions.
  • Skin phototype was clear for 93.5% of the patients.
  • Thirty-two out of 306 patients (10.5%) presented 42 suspicious lesions and these were diagnosed by histological examination as 16 basal-cell carcinomas, seven squamous cell-carcinomas and two in situ melanomas.
  • Skin cancers were localised on the head and neck in 80% of cases.
  • The prevalence of patients with skin cancers was 5.6% in this population.
  • CONCLUSION: The prevalence of skin cancers among patients hospitalized in geriatric hospitals justifies improved training of geriatricians regarding early recognition and dermatological assessment of cutaneous tumours.
  • [MeSH-major] Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Cross-Sectional Studies. Female. France / epidemiology. Hospitalization. Humans. Long-Term Care. Male. Melanoma / diagnosis. Melanoma / epidemiology. Middle Aged. Prevalence. Prospective Studies. Rehabilitation Centers

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  • [CommentIn] Ann Dermatol Venereol. 2008 Oct;135(10):641-3 [18929911.001]
  • (PMID = 18929913.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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44. Leibovitch I, Huilgol SC, Selva D, Lun K, Richards S, Paver R: Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery. J Am Acad Dermatol; 2005 Feb;52(2):295-300
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  • [Title] Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is reported to have a high rate of recurrence with standard wide local excision.
  • METHODS: This prospective, multi-center case series included all patients in Australia treated with MMS for MAC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
  • RESULTS: There were 44 cases; most of them (90.9%) were located in the head and neck area.
  • In 32.5% of cases the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Australia / epidemiology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Child. Databases, Factual. Diagnostic Errors. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prospective Studies. Retrospective Studies. Treatment Outcome

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  • (PMID = 15692477.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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45. Perkins JL, Liu Y, Mitby PA, Neglia JP, Hammond S, Stovall M, Meadows AT, Hutchinson R, Dreyer ZE, Robison LL, Mertens AC: Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. J Clin Oncol; 2005 Jun 1;23(16):3733-41
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  • [Title] Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study.
  • PURPOSE: Nonmelanoma skin cancer (NMSC) has become the most common type of cancer in many populations throughout the world.
  • Because NMSCs are rarely lethal and most cancer registries do not routinely report data regarding these cancers, they have received little attention in studies evaluating long-term effects of cancer therapy.
  • This article reports on the occurrence of secondary NMSC as a long-term effect of cancer therapy in survivors of childhood cancer.
  • PATIENTS AND METHODS: The Childhood Cancer Survivor Study (CCSS) is a cohort study of 5-year survivors of childhood and adolescent cancer from 25 participating institutions in North America.
  • NMSC patients were defined by a history of basal cell or squamous cell carcinoma of the skin after primary malignancy treatment.
  • Location of NMSC included head and neck (43%), back (24%), chest (22%), abdomen and pelvis (5%), extremity (3%), and unknown (4%).
  • CONCLUSION: Long-term survivors of childhood and adolescent cancer who were treated with RT are at highest risk for developing NMSC.
  • Educational efforts need to be directed to this population to facilitate early diagnosis of NMSC and reduction in sun exposure.
  • [MeSH-major] Carcinoma, Basal Cell / mortality. Carcinoma, Squamous Cell / mortality. Skin Neoplasms / mortality. Survivors

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  • (PMID = 15923570.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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46. Jokinen CH, Wolgamot GM, Argenyi ZB: Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin. J Cutan Pathol; 2008 Feb;35(2):215-9
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  • [Title] Collagen-rich variant of benign epithelioid peripheral nerve sheath tumor of the skin.
  • This excessive collagen production emphasizes the importance of adequate sampling to ensure a correct diagnosis.
  • [MeSH-major] Collagen / ultrastructure. Nerve Sheath Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Neck / pathology

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  • (PMID = 18190449.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9007-34-5 / Collagen
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47. Meslemani DM, Jones L: An unusual presentation of nasal type NK/T-cell lymphoma of the nose. Laryngoscope; 2010;120 Suppl 4:S167
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  • [Title] An unusual presentation of nasal type NK/T-cell lymphoma of the nose.
  • OBJECTIVES: Case report of a male with a rare nasal type NK/T cell lymphoma that presented as an aggressive nasal infection superimposed with squamous and basal cell carcinoma.
  • A review of the diagnosis, management, and prognosis nasal type NK/T cell lymphoma will be presented.
  • METHODS: Review of the literature for cases of nasal type NK/T cell lymphoma, with particular attention to its presentations.
  • RESULTS: Differential diagnosis includes aggressive infection of the nasal skin, carcinoma, and lymphoma.
  • CONCLUSION: No cases in the literature of NK/T cell lymphoma have been reported that presented with an aggressive infection with initial biopsies that revealed squamous cell and basal cell carcinoma, which led to surgical management and a definitive diagnosis of Nasal type NK/T cell lymphoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged. Rhinitis / pathology. Sinusitis / pathology

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  • (PMID = 21225765.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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48. Yamauchi M, Yotsuyanagi T, Saito T, Ikeda K, Urushidate S, Higuma Y: Three cases of giant pilomatrixoma--considerations for diagnosis and treatment of giant skin tumours with abundant inner calcification present on the upper body. J Plast Reconstr Aesthet Surg; 2010 Jun;63(6):e519-24
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  • [Title] Three cases of giant pilomatrixoma--considerations for diagnosis and treatment of giant skin tumours with abundant inner calcification present on the upper body.
  • Preoperative biopsies suggested that case 1 was a basal cell carcinoma, but cases 2 and 3 had no malignant features on biopsy.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Pilomatrixoma / pathology. Pilomatrixoma / therapy. Skin Neoplasms / pathology. Skin Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Calcinosis / complications. Calcinosis / diagnosis. Calcinosis / therapy. Female. Hair Diseases / complications. Hair Diseases / diagnosis. Hair Diseases / therapy. Humans. Hypercalcemia / complications. Hypercalcemia / diagnosis. Hypercalcemia / therapy. Male

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  • [Copyright] Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20080452.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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49. Spiegel JH, Khodai N: Tricholemmoma of the nose. Am J Otolaryngol; 2006 Nov-Dec;27(6):430-2
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  • OBJECTIVES: The objectives of this case report are to (1) identify clinical presentations of tricholemmoma, (2) discuss the characteristics of Cowden syndrome and the relationship between this syndrome and tricholemmoma, and (3) differentiate tricholemmoma from other superficial cutaneous tumors such as basal cell carcinoma and granulomas.
  • CONCLUSIONS: Tricholemmoma is described as having a predilection for the head and neck, yet little information has been published about this disorder within the Otolaryngology literature.
  • Otolaryngologist-head and neck surgeons must be familiar with this neoplasm because it can be frequently misdiagnosed as an aggressive cutaneous malignancy and hence can be incorrectly treated.
  • We describe the presentation and diagnosis of tricholemmoma, describe the frequent association of this neoplasm with Cowden syndrome, and report an unusual presentation of tricholemmoma as an intranasal mass.
  • [MeSH-major] Nose Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Follow-Up Studies. Granuloma / diagnosis. Granuloma / pathology. Hamartoma Syndrome, Multiple / diagnosis. Hamartoma Syndrome, Multiple / pathology. Humans. Male. Middle Aged

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  • (PMID = 17084231.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • [Title] Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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51. Hauser J, Homann HH, Drücke D, Kuhnen C, Esenwein SA, Steinau HU: [Desmoplastic neurotropic melanoma. Diagnosis and therapeutic procedures for a rare clinical entity]. Chirurg; 2006 Oct;77(10):939-42
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  • [Title] [Desmoplastic neurotropic melanoma. Diagnosis and therapeutic procedures for a rare clinical entity].
  • These melanomas mostly occur on the head, neck, and face, and a wide local excision of the tumor is probably the most important prognostic factor.
  • In this paper, a 79-year-old patient with a basal cell carcinoma and desmoplastic melanoma on the scalp is described, and the therapeutic procedure is discussed.
  • [MeSH-major] Melanoma / surgery. Neoplasms, Multiple Primary / surgery. Scalp / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Diagnosis, Differential. Female. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Reoperation. Surgical Flaps

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  • (PMID = 16425057.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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52. Zghal M, Triki S, Elloumi-Jellouli A, Jbali A, Gargouri H, Benmously R, Souissi R, Chedly I, Brahim EB, Ayed MB, Fenniche S, Mokhtar I: [Contribution of the cryosurgery in the management of xeroderma pigmentosum]. Ann Dermatol Venereol; 2010 Oct;137(10):605-9
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  • [Transliterated title] L'apport de la cryochirurgie dans la prise en charge du xeroderma pigmentosum.
  • BACKGROUND: Basal cell carcinoma (BCC) occurs frequently in young patients with xeroderma pigmentosum (XP).
  • Mean carcinoma size was 10mm.
  • CONCLUSION: Because of its simplicity, its good safety, its sparing of skin and its reliability of oncological outcome, cryosurgery is the treatment of choice for CBC in XP patients.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Cryosurgery / methods. Facial Neoplasms / surgery. Head and Neck Neoplasms / surgery. Skin Neoplasms / surgery. Xeroderma Pigmentosum / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies. Young Adult

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  • [Copyright] Copyright © 2010. Published by Elsevier Masson SAS.
  • (PMID = 20932439.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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53. Balle JR, Hasselager T: [Kaposi's sarcoma interpreted as haematoma]. Ugeskr Laeger; 2010 Aug 30;172(35):2388-9
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  • Kaposi's sarcoma is a frequent skin cancer in HIV-positive patients, but is relatively uncommon in HIV-negative and non-immune compromised patients.
  • We present a case of Kaposi's sarcoma of the face and scalp in a HIV-negative male with previous facial basal cell carcinoma.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Sarcoma, Kaposi / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Facial Neoplasms / diagnosis. Facial Neoplasms / pathology. Humans. Male. Scalp / pathology

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  • (PMID = 20825744.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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54. Ardigo M, Zieff J, Scope A, Gill M, Spencer P, Deng L, Marghoob AA: Dermoscopic and reflectance confocal microscope findings of trichoepithelioma. Dermatology; 2007;215(4):354-8
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  • Solitary lesions are often confused with basal cell carcinoma (BCC).
  • Reflectance confocal microscopy (RCM) and dermoscopy are imaging tools for in vivo, noninvasive evaluation of skin lesions.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy / methods. Head and Neck Neoplasms / pathology. Microscopy, Confocal. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • [Copyright] 2007 S. Karger AG, Basel
  • (PMID = 17911996.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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55. Tran TA, Muller S, Chaudahri PJ, Carlson JA: Cutaneous carcinosarcoma: adnexal vs. epidermal types define high- and low-risk tumors. Results of a meta-analysis. J Cutan Pathol; 2005 Jan;32(1):2-11
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  • RESULTS: CS occurred in elderly patients (mean of 80 years) on sun-damaged skin, and were keratotic papules of short duration.
  • CS exhibited basal cell carcinoma mixed with atypical fibroxanthoma cell populations.
  • Epidermal-derived (basal or squamous cell carcinoma epithelial component) CS arose on the sun-damaged skin of the head and neck of elderly males (mean age 72 years) and had a 70% 5-year disease-free survival.
  • In contrast, adnexal CS (spiradenocarcinoma, porocarcinoma, proliferating tricholemmal cystic carcinoma, or matrical carcinoma) occurred in younger patients (mean age 58 years), showed recent growth in a long-standing nodule and had a 25% 5-year disease-free survival.
  • Age less than 65 years, recent growth, long-standing skin tumor, and tumor size greater than 2 cm significantly correlated with poor outcome.
  • CONCLUSIONS: Cutaneous CS is an aggressive skin cancer with high risk for advanced disease.
  • [MeSH-major] Carcinosarcoma / pathology. Epithelial Cells / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / classification. Carcinoma, Basal Cell / metabolism. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Male. PubMed. Survival Rate

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  • (PMID = 15660649.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Meta-Analysis
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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56. Cho KJ, Lee DH, Kim NG, Kim J: Fibroepithelioma of pinkus on mucocutaneous junction. J Craniofac Surg; 2010 Nov;21(6):1991-3
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  • Fibroepithelioma of Pinkus is a variant form of basal cell carcinoma that clinically presents as a single or multiple red plaques or flesh-colored nodules without ulceration.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Nasal Mucosa / pathology. Nose Neoplasms / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 21119480.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Padgett JK: Cutaneous lesions: benign and malignant. Facial Plast Surg Clin North Am; 2005 May;13(2):195-202, v
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  • This article reviews the clinical characteristics, histology, biologic behavior, and recommended treatment for several benign and malignant lesions that may arise on the head and neck.
  • Basal and squamous cell carcinoma, lentigo maligna and lentigo maligna melanoma, dermatofibrosarcoma protuberans, and Merkel cell carcinoma are malignant lesions for which surgical excision is the recommended treatment.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / surgery. Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / surgery. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Dermatofibrosarcoma / diagnosis. Dermatofibrosarcoma / surgery. Humans. Hutchinson's Melanotic Freckle / diagnosis. Hutchinson's Melanotic Freckle / surgery. Nevus, Pigmented / diagnosis. Nevus, Pigmented / surgery. Risk Factors. Scalp. Sunlight / adverse effects

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  • (PMID = 15817400.001).
  • [ISSN] 1064-7406
  • [Journal-full-title] Facial plastic surgery clinics of North America
  • [ISO-abbreviation] Facial Plast Surg Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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58. Abdulla FR, Kerns MJ, Mutasim DF: Amelanotic lentigo maligna: a report of three cases and review of the literature. J Am Acad Dermatol; 2010 May;62(5):857-60
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  • BACKGROUND: Amelanotic lentigo maligna is not clinically suspected and is often mistaken for a basal cell carcinoma, squamous cell carcinoma, or dermatitis.
  • CONCLUSION: A high degree of clinical and histologic suspicion is required to make the diagnosis of this clinically nondescript neoplasm.
  • [MeSH-major] Hutchinson's Melanotic Freckle / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Female. Forearm. Humans. Keratosis, Actinic / diagnosis. Male. Middle Aged. Neck

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  • [Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 19766347.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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59. Ram R, Saadat P, Peng D, Vadmal M: Case report and literature review: primary cutaneous carcinosarcoma. Ann Clin Lab Sci; 2005;35(2):189-94
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  • Primary carcinosarcomas of the skin are uncommon.
  • Most of these tumors were seen on the head and neck region of older individuals, both male and female.
  • Microscopically, the more common carcinoma component is a squamous cell carcinoma followed by basal cell carcinoma, whereas the most common sarcoma component is an osteosarcoma.
  • We report an example of this rare entity and speculate on its histogenesis in the skin.
  • [MeSH-major] Carcinosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Humans. Male. Osteosarcoma / pathology

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  • (PMID = 15943184.001).
  • [ISSN] 0091-7370
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Paradela S, Pita-Fernández S, Peña C, Fernández-Jorge B, García-Silva J, Mazaira M, Fonseca E: Complications of ambulatory major dermatological surgery in patients older than 85 years. J Eur Acad Dermatol Venereol; 2010 Oct;24(10):1207-13
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  • BACKGROUND: During the last decades, the progressive ageing of the population has resulted in a rising skin cancer incidence.
  • Studied variables were age, gender, tobacco-alcohol exposure, co-morbid medical conditions, blood-thinning medication, antibiotic prophylaxis, number of lesions, location, histopathological diagnosis, area of skin removed, surgical technique, type of flap, length of surgery, entrance order, suture thread, surgical complications and need of post-operative admission.
  • RESULTS: The most common site was head and neck (82.7%).
  • The most frequent tumour was basal cell carcinoma (45.1%), followed by squamous cell carcinoma (38.7%) and melanoma (8.3%).
  • Length of surgical procedure, area of skin removed and reconstruction with skin-graft were significantly related to higher risk of post-operative complications.
  • [MeSH-major] Ambulatory Surgical Procedures / adverse effects. Dermatologic Surgical Procedures. Skin / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Cellulitis / etiology. Cellulitis / pathology. Female. Humans. Male. Melanoma / surgery. Necrosis / etiology. Necrosis / pathology. Retrospective Studies. Spain. Treatment Outcome

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  • [Copyright] © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.
  • (PMID = 20337810.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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61. Trabelsi A, Stita W, Gharbi O, Kanani N, Sriha B, Korbi S: Malignant proliferating trichilemmal tumor of the scalp: a case report. Dermatol Online J; 2008;14(8):11
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  • BACKGROUND: Malignant proliferating trichilemmal tumor is a rare skin tumor that affects mainly older women.
  • It mimicks differential squamous cell carcinoma and its biological behavior is unpredictable.
  • After wide excision, long term clinical follow up of the patient for early diagnosis of metastases is judicious.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Neoplasms, Basal Cell / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Carcinoma / diagnosis. Cell Division. Diagnosis, Differential. Female. Humans. Keratinocytes / pathology

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  • (PMID = 19061571.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Chiu CS, Lin CY, Kuo TT, Kuan YZ, Chen MJ, Ho HC, Yang LC, Chen CH, Shih IH, Hong HS, Chuang YH: Malignant cutaneous tumors of the scalp: a study of demographic characteristics and histologic distributions of 398 Taiwanese patients. J Am Acad Dermatol; 2007 Mar;56(3):448-52
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  • Age at diagnosis, sex, and histologic types were analyzed.
  • Age at diagnosis ranged from 3 to 103 years.
  • Basal (41.2%) and squamous (16.6%) cell carcinomas were the most common histologic types.
  • LIMITATIONS: In our series, the case number of metastatic scalp malignancies was underestimated because not all patients with metastatic scalp tumors received a scalp skin biopsy.
  • CONCLUSION: Because a wide spectrum of primary and metastatic malignancies can occur on the scalp, scalp inspection should be included in general screening for either skin or internal cancers.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Head and Neck Neoplasms / epidemiology. Scalp. Skin Neoplasms / epidemiology

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  • (PMID = 17141358.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Santos-Silva AR, Correa MB, Vargas PA, Almeida OP, Lopes MA: Bazex syndrome (acrokeratosis paraneoplastica) diagnosed in a patient with oral persistent ulcerations. Head Neck Pathol; 2010 Dec;4(4):312-7
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  • Paraneoplastic syndromes associated with head and neck cancer are rare and have been reported under dermatological, endocrine, hematological, neurological and rheumatological disorders.
  • Bazex syndrome is an intriguing paraneoplasia that can be associated with head and neck squamous cell carcinomas.
  • A range of symmetrical dermatological manifestations, with a clear predilection to extremities, that encompasses erythematous squamous plaques, skin scaling and nail dystrophy can provide a psoriasiform pattern in Bazex syndrome.
  • In addition to these tricky clinical features, the rarity of the disease and the lack of understanding on Bazex syndrome generally make such cases to be mismanaged as psoriasis or lichen planus, causing an important delay in the diagnosis of the underlying malignancy.
  • The authors describe a case of Bazex syndrome that occurred in a patient with a recently diagnosed tongue squamous cell carcinoma.
  • Clinicians should consider paraneoplasia when assessing skin and/or oral persistent lesions.
  • [MeSH-major] Onycholysis / pathology. Oral Ulcer / pathology. Paraneoplastic Syndromes / pathology. Skin Diseases, Papulosquamous / pathology
  • [MeSH-minor] Aneurysm / pathology. Carcinoma, Basal Cell / pathology. Fatal Outcome. Histiocytoma, Benign Fibrous / pathology. Humans. Hypotrichosis / pathology. Male. Middle Aged. Mucous Membrane / pathology. Penile Diseases / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • [Cites] Arch Dermatol. 1984 Apr;120(4):502-4 [6703754.001]
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  • (PMID = 20721648.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Bazex-Dupre-Christol syndrome
  • [Other-IDs] NLM/ PMC2996492
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64. King R, Page RN, Googe PB, Mihm MC Jr: Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous nevus. Mod Pathol; 2005 Oct;18(10):1397-401
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  • The anatomical sites included trunk (7), head and neck (6) and upper extremity (3).
  • The clinical diagnosis was variable and included lentigo maligna, atypical nevus, pigmented basal cell carcinoma, seborrheic keratosis and lentigo.
  • The diagnosis of melanoma was more easily recognized in the complete excision specimens.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Hutchinson's Melanotic Freckle / diagnosis. Lentigo / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15976811.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Findley AB, Pride H: Unusual cystic scalp lesions in Gorlin syndrome: a brief report. Pediatr Dermatol; 2010 Mar-Apr;27(2):204-7
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  • Nevoid basal cell carcinoma syndrome (Gorlin syndrome) is a rare, autosomal dominant syndrome that is known to have variable expressivity in multiple organ systems.
  • We describe the case of a young male child with nevoid basal cell carcinoma syndrome and scalp lesions, including a branchial cleft cyst with respiratory epithelium and a rudimentary meningocele.
  • These are both new, previously unreported findings, possibly associated with nevoid basal cell carcinoma syndrome.
  • [MeSH-major] Basal Cell Nevus Syndrome / diagnosis. Branchioma / diagnosis. Head and Neck Neoplasms / diagnosis. Scalp. Skin Neoplasms / diagnosis


66. Takase K, Ohyagi Y, Furuya H, Nagashima K, Taniwaki T, Kira J: [A case of progressive multifocal leukoencephalopathy presenting white matter MRI lesions extending over the cerebral cortex and a marked decrease in cerebral blood flow on SPECT, and associated with HTLV-I infection]. Rinsho Shinkeigaku; 2005 Jun;45(6):426-30
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  • She had a malignant lymphoma in the left neck and basal cell carcinoma in the right inguinal region.
  • A biopsy of the left parotid gland revealed a diffuse pleomorphic type large B cell lymphoma.
  • Although anti-HTLV-I antibody was positive in the serum and cerebrospinal fluid (CSF), no adult T-cell leukemia (ATL) cells were found in the blood or CSF.
  • CSF examination revealed that the cell count (1/microl), protein level (24 mg/dl), and IgG index (0.4) were all normal.
  • [MeSH-major] Brain / radionuclide imaging. Cerebral Cortex / blood supply. HTLV-I Infections / complications. JC Virus. Leukoencephalopathy, Progressive Multifocal / diagnosis
  • [MeSH-minor] Aphasia, Broca / etiology. Cerebrovascular Circulation. Female. Humans. Lymphoma, B-Cell / complications. Magnetic Resonance Imaging. Middle Aged. Regional Blood Flow. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 16022467.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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67. Yus ES, del Cerro M, Simón RS, Herrera M, Rueda M: Unna's and Miescher's nevi: two different types of intradermal nevus: hypothesis concerning their histogenesis. Am J Dermatopathol; 2007 Apr;29(2):141-51
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  • Eighty- three per cent of the nevi from the head and neck were intradermal nevi, whereas on the trunk and limbs junction and compound nevi were the most frequent (56%).
  • In contradistinction, 87% of the Unna's nevi located on the neck, trunk, and limbs, and 96% of intradermal nevi from these locations were Unna's nevi.
  • Miescher's nevi had more: pilosebaceous follicles within the nevus (100% versus 51%), subnevis folliculitis (12% versus 1%), large isolated melanocytes along the basal epidermal layer (47% versus 11%), multinucleated nevocytes (89% versus 44%), and adipocytes within the nevus (53% versus 11%).
  • [MeSH-major] Nevus, Intradermal / pathology. Nevus, Pigmented / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Child. Diagnosis, Differential. Female. Fibroma / pathology. Humans. Male. Melanoma / pathology. Middle Aged

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  • (PMID = 17414435.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Bojanović M, Zivković-Marinkov E, Veselinović D, Bojanović A, Vucković I: [Malignant tumors of auricula and periauricular area]. Vojnosanit Pregl; 2009 Aug;66(8):611-6
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  • For larger lesions (T4--when lesion is greater than 4.0 cm) and neck metastasis invading cartilage or bone, parotidectomy (15), radical neck dissection (25) and temporal bone resection (9) were performed.
  • CONCLUSION: Carcinoma of auricular and periauricular area should be confirmed by biopsy and histopathologic evaluation.
  • [MeSH-major] Ear Neoplasms. Ear, External. Skin Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged

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  • (PMID = 19780414.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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69. Marcet S: Atypical fibroxanthoma/malignant fibrous histiocytoma. Dermatol Ther; 2008 Nov-Dec;21(6):424-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Atypical fibroxanthoma (AFX) is an unusual spindle cell tumor occurring on actinically damaged skin of the head and neck.
  • Clinically, it is often confused with basal cell carcinoma, squamous cell carcinoma, or even melanoma.
  • Although initially thought to be a diagnosis of exclusion histologically, newer immunostains have helped in the identification of AFX.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology


70. Ciralik H, Coban YK, Arican O: A case of perforating pilomatricoma. J Dermatol; 2006 Jun;33(6):394-8
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  • Pilomatricoma is a rare skin neoplasm, most commonly seen in the head and neck region, and occurring in the first two decades of life.
  • The first histopathological analysis of a punch biopsy from the lesion was reported as basal cell carcinoma.
  • Punch or excisional biopsies are preferred as a method of diagnosis for the majority of cutaneous neoplasms.
  • If total excision is not the method of choice, multiple punch biopsies should be made from different areas in large skin tumors for correct diagnosis.
  • [MeSH-major] Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16700828.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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71. Daneshbod Y, Daneshbod K, Khademi B: Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited. Acta Cytol; 2009 Jan-Feb;53(1):53-70
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  • STUDY DESIGN: In a retrospective review of cytology files of a head and neck referral center from 1990 to 2005, the false positive and false negative interpretations on fine needle aspiration (FNA) of salivary lesions were retrieved.
  • These records and slides were reviewed to identify cytologic characteristics that contributed to false diagnosis.
  • RESULTS: Of a total of 1,040 salivary FNA samples, 376 cases had a final histologic diagnosis with interpretations of benign or malignant.
  • The most common false negative cases were acinic cell carcinoma, epithelial myoepithelial carcinoma, adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Benign cases with false positive diagnosis were Warthin tumor and pleomorphic adenoma.
  • CONCLUSION: Knowledge of cytologic overlaps and pitfalls on salivary gland FNA, as well as clinical and radiologic features, may help clinicians arrive at the appropriate diagnosis and reduce false interpretations.
  • Several clinically important pitfalls with nonsalivary tumors of jaw and skin are demonstrated in our series.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis. Salivary Glands / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Child. Child, Preschool. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Humans. Infant. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity. Young Adult

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  • (PMID = 19248555.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Abbas O, Mahalingam M: Tumor of the follicular infundibulum: an epidermal reaction pattern? Am J Dermatopathol; 2009 Oct;31(7):626-33
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  • To clarify the defining clinical and microscopic features of TFI with special relevance to the histologic variants, we retrospectively reviewed cases with a histologic diagnosis of TFI between 1999 and 2008.
  • Clinically, TFI seems to be slightly more common in men (52% vs. 48%) and more common on the head and neck (around 77%) and presents as plaques (approximately 47%) and as multiple lesions (6%).
  • Of interest, approximately one fourth (25%) were associated with other cutaneous lesions, which included basal cell carcinoma, actinic keratosis, desmoplastic malignant melanoma, junctional melanocytic nevus, tricholemmoma, and epidermal inclusion cyst.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 19633534.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Rizvi SA, Naim M, Alam MS: A giant upper eyelid ossifying pilomatrixoma. Indian J Ophthalmol; 2008 Nov-Dec;56(6):509-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Overlying skin was normal in color and texture.
  • A differential diagnosis of dermoid, epidermoid cyst, chalazion and basal cell carcinoma was made.
  • A diagnosis of pilomatrixoma was made on histopathological features (dystrophic calcification of matrix with keratin and foreign body granulomatous reaction, basaloid cells and shadow cells/ghost cells).
  • [MeSH-major] Eyelid Neoplasms / pathology. Hair Diseases / pathology. Ossification, Heterotopic / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Cites] Cutis. 2002 Jan;69(1):23-6 [11829174.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2003 Dec;129(12):1327-30 [14676160.001]
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  • (PMID = 18974526.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2612977
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74. Premalata CS, Kumar RV, Malathi M, Shenoy AM, Nanjundappa N: Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. Int J Dermatol; 2007 Mar;46(3):306-8
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  • The specimen of the initial surgery consisted of skin-covered tissue with an exophytic firm growth measuring 6 x 5 x 4 cm.
  • The skin surface was rough with areas of ulceration.
  • One was a well-circumscribed tumor located in the superficial dermis with lobules of basaloid cell aggregates with peripheral palisading and with no epidermal connection.
  • Unlike basal cell carcinoma, however, no cleft between the cellular aggregates and stroma was noted.
  • Foci of pigmentation were seen within cellular lobules and these features were consistent with a diagnosis of tricho-blastoma.
  • The third lesion was a spindle cell sarcoma which formed the major part of the lesion, diffusely infiltrating the dermis and subcutaneous tissue, elevating and ulcerating the overlying skin.
  • The wide excision specimen of the recurrent swelling consisted of a skin-covered nodule with ulceration, measuring 3 x 4 x 3 cm, with a gray-white whorled cut surface.
  • Multiple sections showed only spindle cell sarcoma infiltrating the skin and subcutaneous tissue, morphologically similar to the earlier tumor, with ulceration of the overlying skin.
  • Immunohistochemical stains on the spindle cell sarcoma showed positive staining for smooth muscle actin (SMA) (Fig.
  • Correlating the histomorphology and immunohistochemical findings, a diagnosis of cutaneous leiomyosarcoma with tricho-blastoma and syringocystadenoma papilliferum arising on nevus sebaceus was made.
  • The patient received postoperative radiotherapy and is disease free 8 months after diagnosis.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Leiomyosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Scalp. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


75. Antony FC, Sanclemente G, Shaikh H, Trelles AS, Calonje E: Pigment synthesizing melanoma (so-called animal type melanoma): a clinicopathological study of 14 cases of a poorly known distinctive variant of melanoma. Histopathology; 2006 May;48(6):754-62
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  • The head and neck represented the most common site.
  • The clinical diagnosis was of melanoma in seven cases, blue naevus in three cases, benign naevus in three cases and a pigmented basal cell carcinoma in one case.
  • The histological diagnosis of PSM was predicated on the basis of an asymmetrical, predominantly intradermal tumour formed of deeply pigmented, round or short, spindle-shaped dendritic melanocytes with some degree of hyperchromatism and a single nucleolus.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16681693.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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76. Abedalthagafi M, Rushing EJ, Auerbach A, Desouki MM, Marwaha J, Wang Z, Fanburg-Smith JC: Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases. Ann Diagn Pathol; 2010 Feb;14(1):15-22
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  • Tumors presented most commonly in the skin of the scalp followed by the left lower leg, face, nose, lower arm, neck, thigh, eyelid, ear, and temple.
  • Associated basal cell carcinoma was noted in 1 patient; no others had other neoplasms or unrelated surgeries.
  • Requirement for diagnosis includes extravascular proliferation of atypical endothelial cells with mitotic activity in vasoformative, solid, and papillary patterns.
  • [MeSH-major] Dermis / metabolism. Hemangiosarcoma / metabolism. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Neovascularization, Pathologic / metabolism. Skin Neoplasms / metabolism

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20123452.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit
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77. Walsh SN, Hurt MA, Santa Cruz DJ: Psoriasiform keratosis. Am J Dermatopathol; 2007 Apr;29(2):137-40
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  • There was, however, no known clinical diagnosis of psoriasis in any patient, neither at initial presentation nor on follow-up examination.
  • Other sites included the scalp, neck, shoulders, and back.
  • The mean age at diagnosis was 66.8 years.
  • The most common diagnoses, clinically, were seborrheic keratosis, followed by basal cell carcinoma, Bowen's disease, actinic (solar) keratosis, and squamous cell carcinoma, among others.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Psoriasis / pathology. Skin / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lichenoid Eruptions / pathology. Lymphocytes / pathology. Male. Middle Aged. Neutrophils / pathology. Prospective Studies. Terminology as Topic. Time Factors

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  • (PMID = 17414434.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Pardavila R, Rosón E, de la Torre C, González B, Posada C, Feal C, Cruces M: [Linear basal cell carcinoma. Report of two cases]. Actas Dermosifiliogr; 2007 May;98(4):291
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  • [Title] [Linear basal cell carcinoma. Report of two cases].
  • [Transliterated title] Carcinoma basocelular lineal. Presentación de dos casos.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Neoplasms / diagnosis. Head and Neck Neoplasms / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17506964.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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79. Lott DG, Akst LM, Greene D, Roberts JK: T-cell primary cutaneous anaplastic large cell lymphoma mimicking appearance of large basal cell carcinoma. Otolaryngol Head Neck Surg; 2006 Jul;135(1):170-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] T-cell primary cutaneous anaplastic large cell lymphoma mimicking appearance of large basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male


80. De Souza A, Clancy P: Facial skin myiasis associated with advanced skin cancer: failure of early detection. Skinmed; 2006 Jan-Feb;5(1):48-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial skin myiasis associated with advanced skin cancer: failure of early detection.
  • [MeSH-major] Carcinoma, Basal Cell / parasitology. Head and Neck Neoplasms / parasitology. Myiasis / complications. Skin Neoplasms / parasitology
  • [MeSH-minor] Facial Neoplasms / diagnosis. Facial Neoplasms / parasitology. Humans. Male. Middle Aged. Surgical Flaps

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  • [CommentIn] Skinmed. 2006 Jan-Feb;5(1):10-1 [16522976.001]
  • (PMID = 16522987.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Fang W, Chen D, Shang JF, Wang F, Xiao L: [Microcystic adnexal carcinoma: report of two cases]. Zhonghua Bing Li Xue Za Zhi; 2009 Jan;38(1):59-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microcystic adnexal carcinoma: report of two cases].
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Arm. Carcinoembryonic Antigen / metabolism. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Male. Middle Aged. Mucin-1 / metabolism

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  • (PMID = 19489229.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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82. Chuo CB, Slator R, Brown RM, Anderson KD: Management of desmoplastic trichoepithelioma in an infant. J Plast Reconstr Aesthet Surg; 2008 Oct;61(10):1241-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma / pathology. Head and Neck Neoplasms / pathology. Scalp / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Facial Neoplasms / pathology. Female. Humans. Infant. Infant, Newborn. Syringoma / pathology

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  • (PMID = 18554999.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
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