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1. Backous DD, DeMonte F, El-Naggar A, Wolf P, Weber RS: Craniofacial resection for nonmelanoma skin cancer of the head and neck. Laryngoscope; 2005 Jun;115(6):931-7
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  • [Title] Craniofacial resection for nonmelanoma skin cancer of the head and neck.
  • OBJECTIVES/HYPOTHESIS: We reviewed our experience with craniofacial resection for advanced, nonmelanoma skin cancer of the head and neck to determine prognostic factors, local control rate, disease free survival, morbidity, and mortality.
  • Histology included 20 squamous cell carcinomas (SCC) and 15 basal cell carcinomas (BCC).
  • CONCLUSIONS: Acceptable mortality and morbidity is possible using craniofacial resection to treat advanced nonmelanoma skin cancer.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / mortality. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Disease-Free Survival. Face. Female. Follow-Up Studies. Head / surgery. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate


2. Perkins JL, Liu Y, Mitby PA, Neglia JP, Hammond S, Stovall M, Meadows AT, Hutchinson R, Dreyer ZE, Robison LL, Mertens AC: Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. J Clin Oncol; 2005 Jun 1;23(16):3733-41
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  • [Title] Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study.
  • PURPOSE: Nonmelanoma skin cancer (NMSC) has become the most common type of cancer in many populations throughout the world.
  • Because NMSCs are rarely lethal and most cancer registries do not routinely report data regarding these cancers, they have received little attention in studies evaluating long-term effects of cancer therapy.
  • This article reports on the occurrence of secondary NMSC as a long-term effect of cancer therapy in survivors of childhood cancer.
  • PATIENTS AND METHODS: The Childhood Cancer Survivor Study (CCSS) is a cohort study of 5-year survivors of childhood and adolescent cancer from 25 participating institutions in North America.
  • NMSC patients were defined by a history of basal cell or squamous cell carcinoma of the skin after primary malignancy treatment.
  • Location of NMSC included head and neck (43%), back (24%), chest (22%), abdomen and pelvis (5%), extremity (3%), and unknown (4%).
  • CONCLUSION: Long-term survivors of childhood and adolescent cancer who were treated with RT are at highest risk for developing NMSC.
  • Educational efforts need to be directed to this population to facilitate early diagnosis of NMSC and reduction in sun exposure.
  • [MeSH-major] Carcinoma, Basal Cell / mortality. Carcinoma, Squamous Cell / mortality. Skin Neoplasms / mortality. Survivors

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  • (PMID = 15923570.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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3. Noorbala MT, Kafaie P: Analysis of 15 years of skin cancer in central Iran (Yazd). Dermatol Online J; 2007;13(4):1
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  • [Title] Analysis of 15 years of skin cancer in central Iran (Yazd).
  • Skin cancer incidences over a 15-year period (1987-2001) were studied in Yazd, a hot, dry, desert area in the center of Iran.
  • The mean skin cancer frequency was determined to be 28.6 percent and 1,124 patients were diagnosed with skin cancer during this time period, approximately 11 per 100,000.
  • The most common skin cancer was basal cell carcinoma, accounting for 76.9 percent.
  • Squamous cell carcinoma was diagnosed in 18.1 percent and melanoma in 2.7 percent; 2.3 percent were other uncommon skin cancers.
  • The face, head, and neck were the sites of 92 percent of skin cancers.
  • Skin cancer incidence in Iran is lower than western countries.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Melanoma / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 18318998.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Matthews BA, Rhee JS, Neuburg M, Burzynski ML, Nattinger AB: Development of the facial skin care index: a health-related outcomes index for skin cancer patients. Dermatol Surg; 2006 Jul;32(7):924-34; discussion 934
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  • [Title] Development of the facial skin care index: a health-related outcomes index for skin cancer patients.
  • BACKGROUND: Existing health-related quality-of-life (HRQOL) tools do not appear to capture patients' specific skin cancer concerns.
  • OBJECTIVE: To describe the conceptual foundation, item generation, reduction process, and reliability testing for the Facial Skin Cancer Index (FSCI), a HRQOL outcomes tool for skin cancer researchers and clinicians.
  • METHODS: Participants in Phases I to III consisted of adult patients (N=134) diagnosed with biopsy-proven nonmelanoma cervicofacial skin cancer.
  • [MeSH-major] Quality of Life. Skin Neoplasms / psychology. Surveys and Questionnaires / standards
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / psychology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / psychology. Carcinoma, Squamous Cell / surgery. Face / pathology. Female. Humans. Male. Middle Aged. Mohs Surgery. Reproducibility of Results. Severity of Illness Index

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  • (PMID = 16875475.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R03 CA108271
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS12872; NLM/ PMC1810190
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5. Lehnerdt G, Manz D, Jahnke K, Schmitz KJ: [Cutaneous basosquamous cell carcinoma]. HNO; 2008 Mar;56(3):306-11
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  • [Title] [Cutaneous basosquamous cell carcinoma].
  • BACKGROUND: Basosquamous carcinoma (BSC) is a rare malignancy with specific histopathological features of both basal cell (BCC) and squamous cell carcinoma (SCC).
  • Therefore, the histological diagnosis is challenging.
  • One patient was treated by partial removal of the auricle with superficial parotidectomy and ipsilateral neck dissection.
  • In the case of the carcinoma on the forehead, a local excision was performed.
  • CONCLUSIONS: The histological diagnosis of BSC is confirmed by the use of EMA and BerEP4 immunohistological staining.
  • Clinically, BSC is a rare, aggressive skin tumor.
  • Despite the histological similarity to basal cell carcinoma, BSC has an imminent risk of metastasizing.
  • [MeSH-major] Carcinoma, Basosquamous / pathology. Carcinoma, Basosquamous / surgery. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods. Skin Neoplasms / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Treatment Outcome


6. Kyrgidis A, Tzellos TG, Vahtsevanos K, Triaridis S: New concepts for basal cell carcinoma. Demographic, clinical, histological risk factors, and biomarkers. A systematic review of evidence regarding risk for tumor development, susceptibility for second primary and recurrence. J Surg Res; 2010 Mar;159(1):545-56
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  • [Title] New concepts for basal cell carcinoma. Demographic, clinical, histological risk factors, and biomarkers. A systematic review of evidence regarding risk for tumor development, susceptibility for second primary and recurrence.
  • Basal cell carcinoma (BCC) is the commonest cancer in Caucasians and its incidence is increasing.
  • We systematically searched Medline, Embase, and the Cochrane databases for studies assessing the genetic basis of host response to UVR DNA damage, the effect of UVR on generation of reactive oxygen species (ROS), and their detoxification, UVR induced skin immunity modifications, and the role of genomic instability with a focus on the potential use of these biomarkers to the surgical treatment planning and prognosis of BCC patients.
  • [MeSH-major] Biomarkers, Tumor. Carcinoma, Basal Cell / etiology. Neoplasm Recurrence, Local / epidemiology. Neoplasms, Second Primary / epidemiology. Skin Neoplasms / etiology

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19285687.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 86
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7. Vasyukevich K, Zimbler MS: O to Z reconstruction of central upper lip defect. Dermatol Surg; 2007 Jan;33(1):85-7; discussion 87-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / surgery. Female. Humans. Lip Neoplasms / surgery. Mohs Surgery / adverse effects. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 17214685.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Liutkeviciūte-Navickiene J, Mordas A, Simkute S, Bloznelyte-Plesniene L: [Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester]. Medicina (Kaunas); 2009;45(12):937-42
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  • [Title] [Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
  • OBJECTIVE: The incidence of malignant skin tumors is rapidly increasing.
  • Early diagnosis, determining the margins of the tumor, is extremely important to achieve good treatment results.
  • We investigated fluorescence of protoporphyrin IX in skin carcinomas.
  • The study aimed to compare the effectiveness of topical 5-aminolevulinic acid and methyl-aminolevulinate in determining the exact margins of skin tumors.
  • MATERIALS AND METHODS: Fluorescence measurements were performed in 126 patients with malignant, premalignant, and benign skin lesions for detection of the margins of squamous cell carcinoma and basal cell carcinoma.
  • 5-Aminolevulinic acid or its methyl ester was applied to the skin lesion for 2-4 h, and the data of evaluated protoporphyrin IX fluorescence were correlated with the data of morphological tissue examination.
  • RESULTS: Malignant tissue shows a specific red fluorescence when illuminated with blue-violet light, whereas no fluorescence was observed in normal skin.
  • CONCLUSIONS: Fluorescence diagnostics can be used for complete visualization of malignant skin lesions after topical application of 5-aminolevulinic acid or methyl aminolevulinate.
  • It has been shown to be highly effective in the diagnostics of malignant superficial skin lesion.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Fluorescence. Head and Neck Neoplasms / diagnosis. Photosensitizing Agents. Precancerous Conditions / diagnosis. Protoporphyrins. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Esters. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Sensitivity and Specificity. Skin / pathology

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  • (PMID = 20173396.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Lithuania
  • [Chemical-registry-number] 0 / Esters; 0 / Photosensitizing Agents; 0 / Protoporphyrins; 0 / methyl 5-aminolevulinate; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
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9. Khan MK, Powell S, Cox N, Robson A, Murrant N: Cervical in-transit metastasis from a truncal basal cell carcinoma. BMJ Case Rep; 2010;2010
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  • [Title] Cervical in-transit metastasis from a truncal basal cell carcinoma.
  • The authors describe a rare case in which a cervical metastatic basal cell carcinoma (BCC) occurred from a small, non-ulcerated primary lesion on the trunk of a female patient.
  • It was immediately adjacent to the left neck regional nodes and we view this as an in-transit metastasis.
  • [MeSH-major] Carcinoma, Basal Cell / secondary. Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Lymph Nodes / pathology. Neck / pathology. Neck / surgery. Neck Dissection / methods. Neoplasm Staging. Risk Assessment. Thoracic Wall / pathology. Thoracic Wall / surgery. Treatment Outcome

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  • (PMID = 22767568.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027951
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10. Yamauchi M, Yotsuyanagi T, Saito T, Ikeda K, Urushidate S, Higuma Y: Three cases of giant pilomatrixoma--considerations for diagnosis and treatment of giant skin tumours with abundant inner calcification present on the upper body. J Plast Reconstr Aesthet Surg; 2010 Jun;63(6):e519-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three cases of giant pilomatrixoma--considerations for diagnosis and treatment of giant skin tumours with abundant inner calcification present on the upper body.
  • Preoperative biopsies suggested that case 1 was a basal cell carcinoma, but cases 2 and 3 had no malignant features on biopsy.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Pilomatrixoma / pathology. Pilomatrixoma / therapy. Skin Neoplasms / pathology. Skin Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Calcinosis / complications. Calcinosis / diagnosis. Calcinosis / therapy. Female. Hair Diseases / complications. Hair Diseases / diagnosis. Hair Diseases / therapy. Humans. Hypercalcemia / complications. Hypercalcemia / diagnosis. Hypercalcemia / therapy. Male

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  • [Copyright] Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20080452.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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11. Salgarelli AC, Cangiano A, Sartorelli F, Bellini P, Collini M: The bilobed flap in skin cancer of the face: our experience on 285 cases. J Craniomaxillofac Surg; 2010 Sep;38(6):460-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The bilobed flap in skin cancer of the face: our experience on 285 cases.
  • PATIENT AND METHOD: The Zitelli bilobed flap was used to treat 285 consecutive patients with basal cell carcinomas (BCCs) or squamous cell carcinomas (SCCs); 167 men (58.60%) and 118 women (41.40%) between 45 and 98 years of age.
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Patient Satisfaction. Surveys and Questionnaires. Treatment Outcome

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  • [Copyright] Copyright 2009 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19939690.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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12. Fincher EF, Gladstone HB: Dual transposition flaps for the reconstruction of large scalp defects. J Am Acad Dermatol; 2009 Jun;60(6):985-9
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  • We present a dual transposition flap to close a large defect following Mohs surgery for a basal cell carcinoma on the scalp.
  • METHODS: We describe and report the case of a man with a basal cell carcinoma on the scalp vertex who had been referred for Mohs micrographic surgery.
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Humans. Male. Mohs Surgery. Reconstructive Surgical Procedures / methods. Scalp Dermatoses / surgery. Skin Neoplasms / surgery

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  • (PMID = 19467369.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Kazakov DV, Mentzel T, Erlandson RA, Mukensnabl P, Michal M: Clear cell trichoblastoma: a clinicopathological and ultrastructural study of two cases. Am J Dermatopathol; 2006 Jun;28(3):197-201
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  • [Title] Clear cell trichoblastoma: a clinicopathological and ultrastructural study of two cases.
  • Clear cell change in basal cell carcinomas is a well-recognized phenomenon, but is obviously rare in trichoblastomas.
  • We present two cases of clear cell trichoblastoma in which clear cell change was very much prominent, and the results of an ultrastructural study intended to explore the basis of that feature.
  • Common to both tumors was clear cell cytoplasm evident in the majority of the epithelial cells in one case and almost in the entire epithelial cell population in the other.
  • In most epithelial aggregations the epithelial cells with clear cytoplasm often appeared columnar and were arranged in a palisade along a recognizable basal membrane, thus indicative of outer sheath differentiation at the bulb.
  • In addition to the usual organelles, the cytoplasm contained fairly conspicuous tonofilaments and variably sized vacuoles devoid of a limiting membrane, located between the palisaded nuclei and the outer cell membrane.
  • [MeSH-major] Carcinoma, Basal Cell / ultrastructure. Head and Neck Neoplasms / ultrastructure. Neoplasms, Adnexal and Skin Appendage / ultrastructure. Skin Neoplasms / ultrastructure
  • [MeSH-minor] Aged. Basement Membrane / ultrastructure. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Desmosomes / ultrastructure. Epithelial Cells / ultrastructure. Female. Humans. Middle Aged

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  • (PMID = 16778484.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Ganguli-Indra G, Wasylyk C, Liang X, Millon R, Leid M, Wasylyk B, Abecassis J, Indra AK: CTIP2 expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status. PLoS One; 2009;4(4):e5367
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  • [Title] CTIP2 expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status.
  • BACKGROUND: We have demonstrated earlier that CTIP2 is highly expressed in mouse skin during embryogenesis and in adulthood.
  • CTIP2 mutant mice die at birth with epidermal differentiation defects and a compromised epidermal permeability barrier suggesting its role in skin development and/or homeostasis.
  • CTIP2 has also been suggested to function as tumor suppressor in cells, and several reports have described a link between chromosomal rearrangements of CTIP2 and human T cell acute lymphoblast leukemia (T-ALL).
  • The aim of the present study was to look into the pattern of CTIP2 expression in Head and Neck Squamous Cell Carcinoma (HNSCC).
  • METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we analyzed CTIP2 expression in human HNSCC cell lines by western blotting, in paraffin embedded archival specimens by immunohistochemistry (IHC), and in cDNA samples of human HNSCC by qRT-PCR.
  • Elevated levels of CTIP2 protein was detected in several HNSCC cell lines.
  • CTIP2 staining was mainly detected in the basal layer of the head and neck normal epithelium.
  • Nuclear co-localization of CTIP2 protein and cancer stem cell (CSC) marker BMI1 was observed in most, if not all of the cells expressing BMI1 in moderately and poorly differentiated tumors.
  • CONCLUSIONS/SIGNIFICANCE: We report for the first time expression of transcriptional regulator CTIP2 in normal human head and neck epithelia.
  • A statistically significant increase in the expression of CTIP2 was detected in the poorly differentiated samples of the human head and neck tumors.
  • Results demonstrated existence of distinct subsets of cancer cells, which express CTIP2 and underscores the use of CTIP2 and BMI1 co-labeling to distinguish tumor initiating cells or cancer stem cells (CSCs) from surrounding cancer cells.

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  • [ErratumIn] PLoS One. 2009;4(4). doi: 10.1371/annotation/b01c646f-14c7-4aac-8812-9ed4f847c857. Indra, Arup [corrected to Indra, Arup K]
  • (PMID = 19399189.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES000210; United States / NIAMS NIH HHS / AR / R01 AR056008; United States / NIEHS NIH HHS / ES / ES00210
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCL11B protein, human; 0 / BMI1 protein, human; 0 / Biomarkers, Tumor; 0 / DNA Primers; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Repressor Proteins; 0 / Tumor Suppressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
  • [Other-IDs] NLM/ PMC2671404
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15. Lott DG, Akst LM, Greene D, Roberts JK: T-cell primary cutaneous anaplastic large cell lymphoma mimicking appearance of large basal cell carcinoma. Otolaryngol Head Neck Surg; 2006 Jul;135(1):170-1
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  • [Title] T-cell primary cutaneous anaplastic large cell lymphoma mimicking appearance of large basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male


16. Ciralik H, Coban YK, Arican O: A case of perforating pilomatricoma. J Dermatol; 2006 Jun;33(6):394-8
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  • Pilomatricoma is a rare skin neoplasm, most commonly seen in the head and neck region, and occurring in the first two decades of life.
  • The first histopathological analysis of a punch biopsy from the lesion was reported as basal cell carcinoma.
  • Punch or excisional biopsies are preferred as a method of diagnosis for the majority of cutaneous neoplasms.
  • If total excision is not the method of choice, multiple punch biopsies should be made from different areas in large skin tumors for correct diagnosis.
  • [MeSH-major] Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16700828.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Nseir A, Estève E: [Basal cell carcinoma]. Presse Med; 2008 Oct;37(10):1466-73
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  • [Title] [Basal cell carcinoma].
  • Basal cell carcinoma (BCC) accounts for 80% of skin cancers, and its frequency is increasing substantially and regularly.
  • BCC occurs most frequently on the head and neck.
  • [MeSH-major] Carcinoma, Basal Cell. Skin Neoplasms

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  • (PMID = 18687568.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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18. Wei CC, Sanfilippo NJ, Myssiorek D: Re-irradiation of metastatic disease in the neck from xeroderma pigmentosum. Curr Oncol; 2010 Jun;17(3):83-5
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  • [Title] Re-irradiation of metastatic disease in the neck from xeroderma pigmentosum.
  • Mutation of these enzymes leads to the development of multiple basal cell and squamous cell carcinomas.
  • OBJECTIVES: We present a case of xeroderma pigmentosum in a patient with cervical and intraparotid metastatic disease from recurrent cutaneous squamous cell carcinomas of the face and scalp, treated with neck dissection and re-irradiation.
  • With the illustrative case report, we include a literature review of diagnosis, prognostic factors, and treatment, with emphasis on surgical and radiation treatment of cervical metastatic disease from recurrent skin carcinomas.
  • CASE PRESENTATION: A xeroderma pigmentosum patient presented to our clinic with a 2-cm right submental and 1-cm right infra-auricular mass after resection of multiple squamous cell carcinomas of the scalp and face, and external-beam radiation therapy to the right face and neck.
  • Fine-needle aspiration biopsy of the submental mass revealed poorly differentiated squamous cell carcinoma.
  • The patient was brought to the operating room for a right modified radical neck dissection and excision of the right submental and intraparotid mass.
  • Surgical pathology revealed 3 level ia and supraclavicular lymph nodes that were positive for metastatic squamous cell carcinoma.
  • Re-irradiation to the entire right hemi-neck and left submandibular nodal region was performed using opposed oblique portals for the upper neck and a low anterior en face hemi-neck portal.
  • CONCLUSIONS: To our knowledge, this is the first case report in the literature of a patient with xeroderma pigmentosum who subsequently developed metastatic disease from recurrent cutaneous squamous cell carcinoma.

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  • (PMID = 20567629.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2880910
  • [Keywords] NOTNLM ; Xeroderma pigmentosum / head-and-neck cancer / radiation / re-irradiation
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19. Cho KJ, Lee DH, Kim NG, Kim J: Fibroepithelioma of pinkus on mucocutaneous junction. J Craniofac Surg; 2010 Nov;21(6):1991-3
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  • Fibroepithelioma of Pinkus is a variant form of basal cell carcinoma that clinically presents as a single or multiple red plaques or flesh-colored nodules without ulceration.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Nasal Mucosa / pathology. Nose Neoplasms / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 21119480.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Betti R, Radaelli G, Mussino F, Menni S, Crosti C: Anatomic location and histopathologic subtype of basal cell carcinomas in adults younger than 40 or 90 and older: any difference? Dermatol Surg; 2009 Feb;35(2):201-6
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  • [Title] Anatomic location and histopathologic subtype of basal cell carcinomas in adults younger than 40 or 90 and older: any difference?
  • BACKGROUND: Differences in age, site, and histopathologic subtype exist in basal cell carcinoma (BCC).
  • The site was classified as head and neck, trunk, or limbs and the subtype as nodular, superficial, or morpheic-infiltrative.
  • RESULTS: Younger exhibited a lower prevalence of BCCs on the head and neck (36.0% vs 57.3%, p<.01) and a higher prevalence on the trunk (59.3% vs 31.5%, p<.01) and of superficial BCCs (43.0% vs 31.5%, p<.05) than older patients.
  • Morpheic BCCs were mostly on the head and neck (p<.001), and prevalence did not differ between age groups.
  • Nodular BCCs were mostly on the head and neck in older patients (p=.011).
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 19215256.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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21. Eggers G, Flechtenmacher C, Kurzen H, Hassfeld S: Infiltrating basal cell carcinoma of the neck 34 years after irradiation of an haemangioma in early childhood. A case-report. J Craniomaxillofac Surg; 2005 Jun;33(3):197-200
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  • [Title] Infiltrating basal cell carcinoma of the neck 34 years after irradiation of an haemangioma in early childhood. A case-report.
  • A case of a 34-year-old Caucasian male is presented with a basal cell carcinoma deeply infiltrating the structures of the neck, including skeletal muscles and reaching the parotid gland.
  • Thirty years ago the patient had undergone radiotherapy for an infantile haemangioma of the skin of the neck.
  • The effects of this treatment when given in childhood in the aetiology of a basal cell carcinoma are discussed.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Head and Neck Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology
  • [MeSH-minor] Adult. Hemangioma / radiotherapy. Humans. Male. Skin Neoplasms / radiotherapy. Time Factors

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  • (PMID = 15878521.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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22. Bobadilla F, Wortsman X, Muñoz C, Segovia L, Espinoza M, Jemec GB: Pre-surgical high resolution ultrasound of facial basal cell carcinoma: correlation with histology. Cancer Imaging; 2008;8:163-72
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  • [Title] Pre-surgical high resolution ultrasound of facial basal cell carcinoma: correlation with histology.
  • The aim of this study was to analyze the scope of pre-surgical high resolution ultrasound in basal cell carcinoma (BCC).
  • BCC is the most common human cancer.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / ultrasonography. Skin Neoplasms / pathology. Skin Neoplasms / ultrasonography. Ultrasonography, Doppler, Color

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  • (PMID = 18812268.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2556504
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23. De Souza A, Clancy P: Facial skin myiasis associated with advanced skin cancer: failure of early detection. Skinmed; 2006 Jan-Feb;5(1):48-9
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  • [Title] Facial skin myiasis associated with advanced skin cancer: failure of early detection.
  • [MeSH-major] Carcinoma, Basal Cell / parasitology. Head and Neck Neoplasms / parasitology. Myiasis / complications. Skin Neoplasms / parasitology
  • [MeSH-minor] Facial Neoplasms / diagnosis. Facial Neoplasms / parasitology. Humans. Male. Middle Aged. Surgical Flaps


24. Blanchard E, Wierzbicka-Hainaut E, Thellier S, Dupeyron F, Guillet G: [Infiltrative basal cell carcinoma presenting as chronic leg ulcer]. Ann Dermatol Venereol; 2010 Mar;137(3):216-9
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  • [Title] [Infiltrative basal cell carcinoma presenting as chronic leg ulcer].
  • [Transliterated title] Carcinome basocellulaire infiltrant se présentant comme un ulcère de jambe chronique.
  • BACKGROUND: Basal cell carcinoma is the most common carcinoma of the skin and is usually found on the head and neck.
  • We report an unusual case of basal cell carcinoma presenting as a chronic leg ulcer, with underlying bone involvement.
  • Histological examination revealed infiltrative basal cell carcinoma.
  • Treatment consisted of surgical excision of 80% of the primary lesion and coverage with a split-thickness skin graft.
  • Examination of the surgical piece revealed invasion of bone by the carcinoma.
  • DISCUSSION: There is a need for awareness among all doctors of the clinical signs evocative of malignant transformation of a leg ulcer so that a skin biopsy may be performed for suspicious ulcers.
  • Our case is distinguished by the underlying invasion of bone by basal cell carcinoma, as attested by imaging and histology.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Leg Ulcer / pathology. Skin Neoplasms / pathology

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20227566.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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25. Lo CH, Thomson SJ: Nodular cystic metastatic basal cell carcinoma: a rare occurrence. ANZ J Surg; 2007 Jun;77(6):493-4
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  • [Title] Nodular cystic metastatic basal cell carcinoma: a rare occurrence.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / pathology. Scalp. Skin Neoplasms / pathology

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  • [CommentIn] ANZ J Surg. 2007 Dec;77(12):1129 [17973679.001]
  • (PMID = 17501899.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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26. Marcet S: Atypical fibroxanthoma/malignant fibrous histiocytoma. Dermatol Ther; 2008 Nov-Dec;21(6):424-7
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  • Atypical fibroxanthoma (AFX) is an unusual spindle cell tumor occurring on actinically damaged skin of the head and neck.
  • Clinically, it is often confused with basal cell carcinoma, squamous cell carcinoma, or even melanoma.
  • Although initially thought to be a diagnosis of exclusion histologically, newer immunostains have helped in the identification of AFX.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology


27. Birt B, Cowling I, Coyne S, Michael G: The effect of the eye's surface topography on the total irradiance of ultraviolet radiation on the inner canthus. J Photochem Photobiol B; 2007 Apr 2;87(1):27-36
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  • Basal cell carcinoma is the most commonly occurring skin cancer in sub tropical climates.
  • The link between ultraviolet radiation (UVR) and basal cell carcinomas (BCC) is strong.
  • Numerous studies have investigated the spatial distribution of BCCs over the head and neck region and the relative UVR dose, with little or no correlation found between the UVR dose and occurrence rates.
  • [MeSH-minor] Carcinoma, Basal Cell / epidemiology. Face / radiation effects. Humans. Models, Biological. Models, Theoretical. Skin Neoplasms / epidemiology. Software. Tropical Climate

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  • (PMID = 17280839.001).
  • [ISSN] 1011-1344
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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28. Wain RA, Shah SH, Senarath-Yapa K, Laitung JK: Dermal substitutes do well on dura: comparison of split skin grafting+/-artificial dermis for reconstruction of full-thickness calvarial defects. J Plast Reconstr Aesthet Surg; 2010 Dec;63(12):e826-8
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  • [Title] Dermal substitutes do well on dura: comparison of split skin grafting+/-artificial dermis for reconstruction of full-thickness calvarial defects.
  • We believe that artificial dermis coupled with split-thickness skin grafting provides an excellent option for closure of these defects when other techniques are not appropriate.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Chondroitin Sulfates / therapeutic use. Collagen / therapeutic use. Head and Neck Neoplasms / surgery. Scalp. Skin Neoplasms / surgery. Skin Transplantation. Skin, Artificial. Skull / surgery

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  • [Copyright] Copyright © 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • [ReprintIn] Clin Plast Surg. 2012 Jan;39(1):65-7 [22099849.001]
  • (PMID = 20709614.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / integra artificial skin; 9007-28-7 / Chondroitin Sulfates; 9007-34-5 / Collagen
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29. Rodriguez C, Barriuso V, Chan LS: Extensive basal cell carcinoma with probable bone metastasis. Cutis; 2007 Jul;80(1):60-6
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  • [Title] Extensive basal cell carcinoma with probable bone metastasis.
  • Metastasis of basal cell carcinoma (BCC) rarely occurs.
  • Few cases have been reported in the literature; those cases reported generally resulted from chronic, extensive, recurrent lesions on the head or neck.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Basal Cell / secondary. Skin Neoplasms / pathology

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  • (PMID = 17725067.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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30. Sahin B, Ozdemir R, Kocer U, Cologlu H, Kayiran O, Oruc M: Multi-centric basal and squamous cell skin malignancies of the craniofacial region. J Craniofac Surg; 2006 Mar;17(2):265-71
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  • [Title] Multi-centric basal and squamous cell skin malignancies of the craniofacial region.
  • The etiology of skin malignancies is evaluated as multi-factorial.
  • Twenty-seven patients with multi-centric skin malignancies investigated as if having predisposing syndromes.
  • The etiological factors and the classification of skin malignancies are assessed.
  • Four out of 27 patients having multi-centric skin malignancies were realized as syndromic.
  • The localization of these tumors was entirely at the head and neck region.
  • Ninety-eight areas were distinguished as having skin malignancies in 27 patients.
  • Of the 98 malignancies, 24 were squamous cell cancer, 67 were basal cell cancer, and seven were basosquamous cell cancer pathologically.
  • Wound closures were carried out as primarily in 39 excisions; using skin grafts in 21 excisions, local flaps in 28 excisions, and distant flap procedures in 10 regions.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Carcinoma, Squamous Cell / etiology. Head and Neck Neoplasms / etiology. Skin Neoplasms / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Disease Susceptibility. Female. Humans. Male. Middle Aged. Risk Factors. Skin Transplantation. Sunlight / adverse effects. Surgical Flaps. Xeroderma Pigmentosum / complications

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  • (PMID = 16633173.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Jung GW, Metelitsa AI, Dover DC, Salopek TG: Trends in incidence of nonmelanoma skin cancers in Alberta, Canada, 1988-2007. Br J Dermatol; 2010 Jul;163(1):146-54
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  • [Title] Trends in incidence of nonmelanoma skin cancers in Alberta, Canada, 1988-2007.
  • BACKGROUND: Nonmelanoma skin cancer (NMSC) is the most common malignancy affecting caucasian populations and has been seeing global increases in incidence for decades.
  • METHODS: A retrospective analysis of patients from Alberta diagnosed with NMSC from 1988 to 2007 inclusive was conducted with data retrieved from the Alberta Cancer Registry (ACR).
  • RESULTS: From 1988 to 2007, there were 66 192 basal cell carcinomas, 19 959 invasive squamous cell carcinomas (SCC) and 12 494 in situ SCC.
  • Although the head and neck region was the location most often involved with NMSC (71.1%), it revealed a stabilizing trend, whereas most other anatomical regions demonstrated an increasing NMSC incidence rate.
  • As 95-99% of NMSC occurs in patients aged 40 years or older, and with its increased frequency in traditionally clothed areas, the authors recommend regular complete skin examinations starting at 40 years of age.
  • [MeSH-major] Carcinoma in Situ / epidemiology. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 20645981.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Sebastián Villalón-López J, Arturo Valle-Mejía C, Patiño-Lara A, Moreno-Pérez Bertha A, Alejo Muñoz-López J, Alcantar-Andrade A: Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review. J Cancer Res Ther; 2005 Jul-Sep;1(3):132-5
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  • [Title] Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review.
  • Basal cell carcinoma (BCC) is the most frequent type of skin cancer in humans, with cumulative exposure to ultraviolet radiation (UVR) as important risk factor for development of the illness as such as severe solar burns during childhood or adolescence.
  • BCC is mainly located on sun exposed sites, being head and neck the areas of more incidence; although nose, eyelids and periorbitary tissue are unfavorable due to cosmetic results that BCC involves.
  • Mohs' micrographic surgery is the standard treatment for all non-melanoma skin cancer.
  • Orbital exenteration is also used for treatment of malignancies of ocular tissues, mainly squamous cell carcinoma, sebaceous cell carcinoma and BCC.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Maxilla / surgery. Orbit Evisceration / methods
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / drug therapy. Humans. Male

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  • (PMID = 17998643.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 15
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33. Mehrany K, Weenig RH, Pittelkow MR, Roenigk RK, Otley CC: High recurrence rates of squamous cell carcinoma after Mohs' surgery in patients with chronic lymphocytic leukemia. Dermatol Surg; 2005 Jan;31(1):38-42; discussion 42
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  • [Title] High recurrence rates of squamous cell carcinoma after Mohs' surgery in patients with chronic lymphocytic leukemia.
  • Squamous and basal cell carcinomas also exhibit greater subclinical tumor extension in patients with chronic lymphocytic leukemia.
  • OBJECTIVE: The purpose of this study was to estimate and compare the recurrence rates of squamous cell carcinoma after Mohs' surgery in patients with chronic lymphocytic leukemia compared with those in controls and to evaluate differences among squamous cell carcinoma size and histologic grade.
  • Both patients and controls underwent Mohs' surgery for squamous cell carcinoma of the head and neck at the Mayo Clinic between March 1988 and April 1999.
  • RESULTS: Twenty-eight patients who underwent Mohs' surgery for 57 squamous cell carcinomas had 7 recurrences.
  • Squamous cell carcinoma was seven times more likely to recur in patients with chronic lymphocytic leukemia than in controls (p = .003).
  • CONCLUSION: The recurrence rates of squamous cell carcinoma were significantly higher in patients with chronic lymphocytic leukemia.
  • Squamous cell carcinomas in patients with chronic lymphocytic leukemia did not exhibit a significant difference in histologic grade or clinical difference in preoperative tumor size.
  • Close surveillance for squamous cell carcinoma recurrence is warranted in patients with chronic lymphocytic leukemia.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / complications. Neoplasm Recurrence, Local / epidemiology. Skin Neoplasms / pathology


34. Elamin I, Zecević RD, Vojvodić D, Medenica L, Pavlović MD: Cytokine concentrations in basal cell carcinomas of different histological types and localization. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Jun;17(2):55-9
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  • [Title] Cytokine concentrations in basal cell carcinomas of different histological types and localization.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common malignant skin tumor.
  • OBJECTIVE: We were interested in comparing cytokine levels in BCC and cutaneous squamous cell tumors with BCC of different localization and histological subtypes.
  • MATERIAL AND METHODS: Explants from freshly excised BCC from 18 patients, and cutaneous squamous cell tumors (solar keratoses and Bowen's disease) from 9 patients were cultivated for 24 h.
  • RESULTS: Tissue explants of BCC contained significantly higher concentrations of IL-1beta, IL-4, IL-5, and IL-6 compared to those of squamous cell tumors.
  • Higher levels of TNF-alpha (p = 0.042), IL-4 (p = 0.028), and IL-5 (p = 0.012) were found in tumors localized to the head and neck compared to those on the trunk or extremities.
  • CONCLUSIONS: Confirming the earlier findings that BCC is a tumor with a Th2 cytokine microenvironment, this study further shows that BCC situated on the head and neck produce even more of certain Th2 cytokines (IL-4 and IL-5) and TNF-alpha, a crucial immunosuppressive cytokine released upon UVB irradiation.
  • [MeSH-major] Carcinoma, Basal Cell / chemistry. Cytokines / analysis. Skin Neoplasms / chemistry
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / chemistry. Female. Humans. Interleukin-4 / analysis. Interleukin-5 / analysis. Male. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 18709290.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovenia
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-5; 0 / Tumor Necrosis Factor-alpha; 207137-56-2 / Interleukin-4
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35. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • [Title] Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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36. Kimyai-Asadi A, Goldberg LH, Jih MH: Accuracy of serial transverse cross-sections in detecting residual basal cell carcinoma at the surgical margins of an elliptical excision specimen. J Am Acad Dermatol; 2005 Sep;53(3):469-74
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  • [Title] Accuracy of serial transverse cross-sections in detecting residual basal cell carcinoma at the surgical margins of an elliptical excision specimen.
  • OBJECTIVE: Our purpose was to estimate the accuracy of serial transverse cross-sectioning (bread-loafing) at 4-mm intervals in detecting the presence of residual tumor at the margins of well-defined facial basal cell carcinomas excised as an ellipse with 2-mm surgical margins.
  • METHODS: Forty-two small (<1 cm), well-defined, primary, nonmorpheaform facial basal cell carcinomas that had been excised as an ellipse with 2-mm margins and that had positive surgical margins utilizing en-face Mohs sections were included.
  • CONCLUSION: Bread-loafing at 4-mm intervals of elliptical excision specimens from facial basal cell carcinomas excised with 2-mm surgical margins is only 44% sensitive in detecting residual tumor at the surgical margins.
  • We recommend complete histologic margin control by using en face tissue orientation (Mohs technique) to identify residual tumor and reduce the risk of tumor recurrence after elliptical excision of facial basal cell carcinomas.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / surgery. Mohs Surgery. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 16112355.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Bogdanov-Berezovsky A, Rosenberg L, Cagniano E, Silberstein E: The role of frozen section histological analysis in the treatment of head and neck skin basal and squamous cell carcinomas. Isr Med Assoc J; 2008 May;10(5):344-5
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  • [Title] The role of frozen section histological analysis in the treatment of head and neck skin basal and squamous cell carcinomas.
  • BACKGROUND: Skin basal and squamous cell carcinomas together account for over half of all newly diagnosed cancer cases.
  • Frozen section control of surgical margins is often required in the head and neck region.
  • METHODS: This was a retrospective study of 169 cutaneous basal and squamous cell carcinomas excised with surgical margins diagnosed by frozen section and confirmed by permanent paraffin sections.
  • The data included patients' age, gender, clinical and histopathological diagnosis, as well as characteristics of the lesions.
  • RESULTS: There were 149 (88%) basal cell carcinomas and 20 (12%) squamous cell carcinomas.
  • We did not find any correlation between false positive or false negative margins and patients' age, gender, tumor size, tumor location, or the presence of sun-damaged skin.
  • CONCLUSIONS: Our findings support the use of frozen section margin control in selected patients suffering from non-melanoma skin cancer of the head and neck.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Frozen Sections. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 18605355.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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38. Cernea CR, Ferraz AR, de Castro IV, Sotto MN, Logullo AF, Bacchi CE, Potenza AS: p53 and skin carcinomas with skull base invasion: a case-control study. Otolaryngol Head Neck Surg; 2006 Mar;134(3):471-5
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  • [Title] p53 and skin carcinomas with skull base invasion: a case-control study.
  • BACKGROUND: Some skin carcinomas may be very aggressive.
  • In this study, p53 expression was evaluated in basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) with skull base invasion, and was compared to tumors with good outcome.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology. Skull Base Neoplasms / pathology. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16500447.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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39. D'Arpa S, Cordova A, Moschella F: Further application of the bilobed flap: the split bilobed flap for reconstruction of composite posterior auricular and mastoid defects. J Plast Reconstr Aesthet Surg; 2006;59(12):1330-5
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  • In this article a modified bilobed flap from mastoid and lateral neck skin for reconstruction of complex defects of the posteromedial surface of the auricle and mastoid skin, with the preservation of the retroauricular sulcus, is described.
  • It is in fact a shaded area with little aesthetic relevance and direct closure, skin grafting and even secondary healing are used for skin cancer defects repair.
  • Also mastoid skin defects can be repaired with simple techniques such as skin grafts or transposition flaps from the remaining mastoid skin or from the neck.
  • On the other hand, cancers involving the postero-medial auricular surface, the retroauricular sulcus and the mastoid skin require wide and deep resections that involve the posterior auricular muscles and reach the perichondral and periosteal surfaces.
  • Transposition flaps from the remaining mastoid skin, due to the lack of skin laxity, are not feasible because the donor site cannot be closed.
  • Two patients, both affected by basal cell carcinoma involving the posteromedial auricular surface and the mastoid skin have been treated with this flap.
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / surgery. Ear Neoplasms / surgery. Head and Neck Neoplasms / surgery. Humans. Male. Mastoid

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  • (PMID = 17113512.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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40. Betz CS, Rauschning W, Stranadko EP, Riabov MV, Albrecht V, Nifantiev NE, Hopper C: Optimization of treatment parameters for Foscan-PDT of basal cell carcinomas. Lasers Surg Med; 2008 Jul;40(5):300-11
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  • [Title] Optimization of treatment parameters for Foscan-PDT of basal cell carcinomas.
  • BACKGROUND AND OBJECTIVE: Basal cell carcinomas (BCCs) are the most common form of skin cancers with high and increasing incidence rates.
  • STUDY DESIGN/MATERIALS AND METHODS: mTHPC-PDT was performed in 117 patients with a total of 460 BCCs with diagnosis confirmed by scratch cytology.
  • [MeSH-major] Carcinoma, Basal Cell / drug therapy. Head and Neck Neoplasms / drug therapy. Mesoporphyrins / therapeutic use. Photochemotherapy. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 18563776.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mesoporphyrins; 0 / Photosensitizing Agents; FU21S769PF / temoporfin
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41. Monhian N, Jewett BS, Baker SR, Varani J: Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients. Arch Facial Plast Surg; 2005 Jul-Aug;7(4):238-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients.
  • OBJECTIVE: To obviate the difficulty of ruling out confounding variables (eg, age, individual variability) as the source of differences seen when comparing tumor tissue and control tissue from unrelated individuals, we examined the expression of matrix metalloproteinase (MMP)-1 (interstitial collagenase) and MMP-9 (92-kDa gelatinase B) in histologically normal skin immediately adjacent to basal cell carcinomas (peritumoral tissue) after Mohs micrographic surgery and postauricular skin from the same patients.
  • DESIGN: Peritumoral and postauricular skin samples were obtained from 17 patients undergoing Mohs surgery.
  • RESULTS: The expression levels of MMP-1 and MMP-9 were consistently elevated in the peritumoral tissue compared with skin from the distal site.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Matrix Metalloproteinase 1 / biosynthesis. Matrix Metalloproteinase 9 / biosynthesis. Skin / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 16027344.001).
  • [ISSN] 1521-2491
  • [Journal-full-title] Archives of facial plastic surgery
  • [ISO-abbreviation] Arch Facial Plast Surg
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK59169
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.7 / Matrix Metalloproteinase 1
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42. Lott DG, Manz R, Koch C, Lorenz RR: Aggressive behavior of nonmelanotic skin cancers in solid organ transplant recipients. Transplantation; 2010 Sep 27;90(6):683-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive behavior of nonmelanotic skin cancers in solid organ transplant recipients.
  • BACKGROUND: The increased incidence of skin cancers in solid organ transplant recipients (OTR) has been well established.
  • The purpose of this study was to determine the aggressiveness of nonmelanotic skin cancers in a large transplant population compared with an immunocompetent control population with similar cancers.
  • METHODS: Immunosuppressed transplanted patients and an immunocompetent control group matched in size with squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) were evaluated for the factors of aggressiveness.
  • [MeSH-major] Aggression / psychology. Organ Transplantation / psychology. Skin Neoplasms / psychology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / psychology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / psychology. Child. Humans. Intensive Care Units / statistics & numerical data. Middle Aged


43. Heppt W: [Skin tumors in facial plastic surgery]. HNO; 2009 Apr;57(4):324-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Skin tumors in facial plastic surgery].
  • As the incidence of facial skin tumors is rising, otorhinolaryngologists are becoming more and more involved in the field of facial plastic surgery.
  • The most common histologic findings are actinic keratosis and basal cell carcinoma.
  • In planning tumor resection and defect repair, many factors, including histology, size, and localization of the tumor as well as conditions of the adjacent skin, must be considered.
  • Because of skin laxity, most small and midsize facial defects can be closed directly or with high-tension sutures under skin expansion.
  • More extensive defects and those located in critical areas require pedicled flaps or free grafts transferring skin from adjacent or distant areas.
  • [MeSH-major] Facial Neoplasms / diagnosis. Facial Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / trends. Reconstructive Surgical Procedures / trends. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery

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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Feb;99(2):136-41 [15660081.001]
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  • (PMID = 19347378.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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44. Karsidag S, Ozcan A, Ozkaya O, Ugurlu K, Bas L: Use of wide bipedicled pericranial flap in anterior scalp reconstruction. J Craniofac Surg; 2009 Nov;20(6):2248-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Scalp / surgery. Skin Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Ear, External / blood supply. Fascia / transplantation. Humans. Male. Middle Aged. Periosteum / transplantation. Skin Transplantation


45. Rieger KE, Linos E, Egbert BM, Swetter SM: Recurrence rates associated with incompletely excised low-risk nonmelanoma skin cancer. J Cutan Pathol; 2010 Jan;37(1):59-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence rates associated with incompletely excised low-risk nonmelanoma skin cancer.
  • BACKGROUND: Reported recurrence rates for transected nonmelanoma skin cancer (NMSC) vary widely, and few studies have addressed recurrence of tumors followed clinically or treated with nonsurgical modalities.
  • METHODS: Retrospective review of dermatopathology records from January 1999 to January 2005 was conducted to identify biopsies or excision specimens with histologically transected basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) which were not subsequently excised.
  • Multivariate logistic regression identified three significant predictors of recurrence: tumor location on the head and neck (p = 0.041), tumor size (p = 0.00741) and superficial subtype of BCC (p = .035).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Neoplasm Recurrence, Local / diagnosis. Skin Neoplasms / pathology

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  • [Copyright] Copyright © 2009 John Wiley & Sons A/S.
  • (PMID = 19615009.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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46. Ananthakrishna R, Goel R, Padhan P, Mathew J, Danda D: Relapsing polychondritis--case series from South India. Clin Rheumatol; 2009 Jun;28 Suppl 1:S7-10
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  • Relapsing polychondritis (RP) is a rare recurring inflammatory disorder with variable clinical course.
  • In between 1995 and 2008, seven patients fulfilling the McAdam-Damiani-Levine criteria for diagnosis of relapsing polychondritis were identified.
  • An average of 20 months, ranging from 3 months to 6 years, elapsed before the patient presented to us seeking a diagnosis.
  • Various structural involvement in our series were as follows: pinna in four (57%), nasal cartilage in five (71%), joints in three (43%), eyes in three (43%), laryngotracheal tree in three (43%), inner ear in one (14.3%), skin in one (14.3%), and heart in one (14.3%).
  • Although RP is an uncommon disorder, clinicians should be aware of the manifestations so as to initiate prompt treatment and prevent complications.
  • Our series reports less frequent auricular cartilage and skin involvement and an exceptional case of basal cell carcinoma, although the other manifestations were similar to that seen in Caucasian and other Asian populations.

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  • (PMID = 18946713.001).
  • [ISSN] 1434-9949
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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47. Leivonen SK, Ala-Aho R, Koli K, Grénman R, Peltonen J, Kähäri VM: Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells. Oncogene; 2006 Apr 27;25(18):2588-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.
  • Squamous cell carcinoma (SCC) cells of the head and neck specifically express collagenase-3 (matrix metalloproteinase-13 (MMP-13)), the expression of which correlates with their invasion capacity.
  • Here, we have examined the role of Smad signaling in regulating MMP-13 expression and in invasion of head and neck SCC cells.
  • Basal activation of Smad3 and p38 was noted in SCC cells without exogenous TGF-beta stimulation, and adenoviral delivery of Smad7 and dominant-negative Smad3 inhibited p38 activation in these cells.
  • Disruption of Smad signaling by adenoviral expression of kinase-defective TGF-beta type I receptor (activin-receptor-like kinase-5), Smad7, and dominant-negative Smad3 potently suppressed the basal and TGF-beta-induced expression of MMP-13 and MMP-1 in SCC cells, and inhibited their basal and TGF-beta-induced invasion through Matrigel and type I collagen.
  • Adenoviral overexpression of Smad7 in cutaneous and oral SCC cells significantly inhibited their implantation in skin of SCID mice and growth of xenografts in vivo, as compared to LacZ adenovirus-transduced control cells.
  • Together, these results show that Smad signaling plays an important role in promoting the invasive phenotype of human head and neck SCC cells by upregulating their collagenase expression.
  • [MeSH-major] Carcinoma, Squamous Cell / enzymology. Collagenases / metabolism. Head and Neck Neoplasms / enzymology. Signal Transduction / physiology. Smad2 Protein / metabolism. Smad3 Protein / metabolism. Smad7 Protein / metabolism
  • [MeSH-minor] Adenoviridae / genetics. Animals. Blotting, Northern. Cell Proliferation. Collagen Type I / metabolism. Humans. Matrix Metalloproteinase 13. Mice. Mice, SCID. Neoplasm Invasiveness. Transforming Growth Factor beta / pharmacology. Transplantation, Heterologous. Tumor Cells, Cultured. p38 Mitogen-Activated Protein Kinases / metabolism

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  • (PMID = 16407850.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Smad2 Protein; 0 / Smad3 Protein; 0 / Smad7 Protein; 0 / Transforming Growth Factor beta; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.4.24.- / Collagenases; EC 3.4.24.- / MMP13 protein, human; EC 3.4.24.- / Matrix Metalloproteinase 13; EC 3.4.24.- / Mmp13 protein, mouse; EC 3.4.24.- / collagenase 1
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48. Ghafouri-Fard S, Abbasi A, Moslehi H, Faramarzi N, Taba Taba Vakili S, Mobasheri MB, Modarressi MH: Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features. Br J Dermatol; 2010 Apr;162(4):772-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.
  • BACKGROUND: Basal cell carcinoma (BCC) is characterized by a low rate of metastasis, slow growth and strong stroma dependency, with significant morbidity and public health burden.
  • Cancer-testis (CT) genes are specifically expressed in normal testis, fetal ovary and different types of cancers.
  • Testis immune privileged status makes CT genes promising candidates as cancer markers, vaccines and immunotherapy.
  • OBJECTIVES: To find new CT genes as cancer markers and candidate genes for immunotherapy and to correlate pathological and clinical features with their expression in patients with BCC.
  • Their expression patterns were analysed in 78 BCC and 15 normal skin samples using semiquantitative reverse transcription-polymerase chain reaction.
  • RESULTS: SPATA19, TEX101, ODF1, ODF2 and ODF3 were expressed in 56.6%, 38.2%, 2.6%, 17.4% and 2.6% of BCCs but not in normal skin samples.
  • SPATA19 expression was correlated with a history of cancer radiotherapy (P < 0.001).
  • Significant associations were found between expression of TEX101 with nodular subtype, ODF2 with infiltrating subtype, and ODF1 with tumours located on the neck.
  • CONCLUSIONS: We report five new CT antigens, of which SPATA19 and TEX101 may be possible targets for cancer immunotherapy and novel markers for early detection of BCC.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Heat-Shock Proteins / genetics. Mitochondrial Proteins / genetics. Seminal Plasma Proteins / genetics. Skin Neoplasms / genetics. Testis / immunology

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  • (PMID = 19886887.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Antigens, Nuclear; 0 / Biomarkers, Tumor; 0 / Heat-Shock Proteins; 0 / Mitochondrial Proteins; 0 / PASD1 protein, human; 0 / SPATA19 protein, human; 0 / Seminal Plasma Proteins
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49. Paradela S, Pita-Fernández S, Peña C, Fernández-Jorge B, García-Silva J, Mazaira M, Fonseca E: Complications of ambulatory major dermatological surgery in patients older than 85 years. J Eur Acad Dermatol Venereol; 2010 Oct;24(10):1207-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: During the last decades, the progressive ageing of the population has resulted in a rising skin cancer incidence.
  • Studied variables were age, gender, tobacco-alcohol exposure, co-morbid medical conditions, blood-thinning medication, antibiotic prophylaxis, number of lesions, location, histopathological diagnosis, area of skin removed, surgical technique, type of flap, length of surgery, entrance order, suture thread, surgical complications and need of post-operative admission.
  • RESULTS: The most common site was head and neck (82.7%).
  • The most frequent tumour was basal cell carcinoma (45.1%), followed by squamous cell carcinoma (38.7%) and melanoma (8.3%).
  • Length of surgical procedure, area of skin removed and reconstruction with skin-graft were significantly related to higher risk of post-operative complications.
  • [MeSH-major] Ambulatory Surgical Procedures / adverse effects. Dermatologic Surgical Procedures. Skin / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Cellulitis / etiology. Cellulitis / pathology. Female. Humans. Male. Melanoma / surgery. Necrosis / etiology. Necrosis / pathology. Retrospective Studies. Spain. Treatment Outcome

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  • [Copyright] © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.
  • (PMID = 20337810.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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50. Tiftikcioğlu YO, Karaaslan O, Aksoy HM, Aksoy B, Koçer U: Basal cell carcinoma in Turkey. J Dermatol; 2005 Dec;32(12):946-50
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  • [Title] Basal cell carcinoma in Turkey.
  • Basal cell carcinoma (BCC) is the most common form of cancer in Caucasians.
  • The age and sex distribution, personal and family histories of the patients, skin type, sites and sizes of the lesions, clinical types of the lesions, status of the surgical margins, and incidences of recurrence were analyzed.
  • Of the tumors, 91.5% occurred on the head and neck.
  • There were also personal and/or family histories of cancer in 24.8% of our cases.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / epidemiology. Skin Neoplasms / diagnosis. Skin Neoplasms / epidemiology

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  • (PMID = 16471455.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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51. Asuquo ME, Ngim O, Ugare G, Omotoso J, Ebughe G: Major dermatologic malignancies encountered in a teaching hospital surgical department in South Nigeria. Am J Clin Dermatol; 2008;9(6):383-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Dermatologic malignancies are among the most common form of cancer.
  • However, dark-skinned individuals of African descent are said to be far less likely than fair-skinned individuals to develop skin cancer.
  • Significant differences in the pattern of skin malignancy have also been observed in different regions of Africa.
  • Squamous cell carcinoma (SCC) was the most common (n = 23; 37%), followed by Kaposi sarcoma (KS) [n = 17; 27%].
  • Other malignancies included basal cell carcinoma (BCC), melanoma, and dermatofibrosarcoma protuberans (DFSP) [n = 5; 8% each].
  • The peak age varied with the type of cancer but none was found in patients in the first decade of life.
  • The lower limb was the most frequent site of SCC (Marjolin ulcer), KS, and melanoma, while BCC was most common on the head, neck, and upper limb.
  • [MeSH-major] Skin Neoplasms / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Africa / epidemiology. African Continental Ancestry Group. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Female. Hospitals, Teaching / statistics & numerical data. Humans. Male. Melanoma / pathology. Melanoma / surgery. Neoplasm Metastasis. Nigeria. Retrospective Studies. Sarcoma, Kaposi / pathology. Sarcoma, Kaposi / surgery

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  • (PMID = 18973404.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
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52. Bernard P, Dupuy A, Brun P, Sasko A, Duru G, Nicoloyannis N, Decuypere L, Grob JJ: [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists]. Ann Dermatol Venereol; 2007 Jun-Jul;134(6-7):527-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists].
  • [Transliterated title] Evaluation médico-économique de la prise en charge des carcinomes basocellulaires superficiels et des kératoses actiniques multiples par les dermatologues français.
  • INTRODUCTION: To date, no prospective studies have been conducted in France describing the management of actinic keratoses (AK) and superficial basal cell carcinomas (sBCC).
  • The therapeutic modalities, the physicians involved and the laboratory examinations during the 3 months following diagnosis were recorded prospectively.
  • RESULTS: 512 patients with sBCC (mean age: 69 years; sex-ratio M/F: 0.92) were included in the study. sBCC was isolated in 80% of cases, measured less than 2 cm in 90%, and was located on the head/neck in 51% and on the trunk in 37%.
  • Histological confirmation of diagnosis of BCC was obtained in 85% of cases.
  • AKs were located on the head/neck in 74% of cases and on the trunk in 6%.
  • [MeSH-major] Carcinoma, Basal Cell / economics. Carcinoma, Basal Cell / surgery. Health Care Costs. Photosensitivity Disorders / economics. Photosensitivity Disorders / therapy. Skin Neoplasms / economics. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Cost-Benefit Analysis. Cryotherapy / economics. Female. France. Head. Humans. Male. Neck. Photochemotherapy / economics. Practice Guidelines as Topic. Prospective Studies. Sunlight / adverse effects. Surveys and Questionnaires. Thorax

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  • (PMID = 17657178.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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53. Lorenz KJ, Maier H: One-stage reconstruction of the entire upper lip and the columella with a modified bilateral nasolabial flap. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):973-6
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  • In this article, we present the case of an 85-year-old female patient with an extensive, aggressive and highly invasive basal cell carcinoma of the upper lip and the columella.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Lip Neoplasms / surgery. Microsurgery / methods. Nose Neoplasms / surgery. Skin Neoplasms / surgery. Surgical Flaps / innervation

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  • [Cites] HNO. 1981 Jan;29(1):27-33 [7204110.001]
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  • (PMID = 19771441.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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54. Meslemani DM, Jones L: An unusual presentation of nasal type NK/T-cell lymphoma of the nose. Laryngoscope; 2010;120 Suppl 4:S167
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  • [Title] An unusual presentation of nasal type NK/T-cell lymphoma of the nose.
  • OBJECTIVES: Case report of a male with a rare nasal type NK/T cell lymphoma that presented as an aggressive nasal infection superimposed with squamous and basal cell carcinoma.
  • A review of the diagnosis, management, and prognosis nasal type NK/T cell lymphoma will be presented.
  • METHODS: Review of the literature for cases of nasal type NK/T cell lymphoma, with particular attention to its presentations.
  • RESULTS: Differential diagnosis includes aggressive infection of the nasal skin, carcinoma, and lymphoma.
  • CONCLUSION: No cases in the literature of NK/T cell lymphoma have been reported that presented with an aggressive infection with initial biopsies that revealed squamous cell and basal cell carcinoma, which led to surgical management and a definitive diagnosis of Nasal type NK/T cell lymphoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Lymphoma, T-Cell, Cutaneous / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged. Rhinitis / pathology. Sinusitis / pathology

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  • (PMID = 21225765.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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55. Rosen H, Schmidt B, Lam HP, Meara JG, Labow BI: Management of nevus sebaceous and the risk of Basal cell carcinoma: an 18-year review. Pediatr Dermatol; 2009 Nov-Dec;26(6):676-81
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  • [Title] Management of nevus sebaceous and the risk of Basal cell carcinoma: an 18-year review.
  • Nevus sebaceous (NS) is a common congenital hamartoma of the skin, usually found on the head and neck.
  • It may undergo malignant transformation to basal cell carcinoma (BCC).
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Nevus / epidemiology. Nevus / surgery. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / surgery. Skin Neoplasms / epidemiology


56. Maghami EG, Talbot SG, Patel SG, Singh B, Polluri A, Bridger PG, Cantu G, Cheesman AD, De Sa G, Donald P, dos Santos LR, Fliss D, Gullane P, Janecka I, Kamata SE, Kowalski LP, Kraus DH, Levine PA, Pradhan S, Schramm V, Snyderman C, Wei WI, Shah JP: Craniofacial surgery for nonmelanoma skin malignancy: report of an international collaborative study. Head Neck; 2007 Dec;29(12):1136-43
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  • [Title] Craniofacial surgery for nonmelanoma skin malignancy: report of an international collaborative study.
  • BACKGROUND: This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC).
  • Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS.
  • [MeSH-major] Skin Neoplasms / pathology. Skull Neoplasms / secondary. Skull Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brain Neoplasms / mortality. Brain Neoplasms / secondary. Brain Neoplasms / surgery. Carcinoma, Basal Cell / mortality. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Chemotherapy, Adjuvant. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. International Cooperation. Male. Middle Aged. Neoplasm Invasiveness. Postoperative Complications. Radiotherapy, Adjuvant. Surgical Flaps

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  • (PMID = 17764086.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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57. Nazarian Y, Shalmon B, Horowitz Z, Bedrin L, Pfeffer MR, Talmi YP: Merkel cell carcinoma of unknown primary site. J Laryngol Otol; 2007 Apr;121(4):e1
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  • [Title] Merkel cell carcinoma of unknown primary site.
  • Merkel cell carcinoma is an uncommon and aggressive primary neuroendocrine skin malignancy which mostly affects the extremities and the head and neck region of elderly patients.
  • Merkel cell carcinoma occurs with increased frequency in sun-exposed areas, in individuals exposed to arsenic and in immunosuppressed patients.
  • Many patients with Merkel cell carcinoma present with other malignancies, mainly skin cancers.
  • Merkel cell carcinoma of unknown primary site is rare, and the majority of the few cases described have not been from head and neck areas.
  • We present a case of Merkel cell carcinoma of unknown primary site, with upper neck and distant metastases.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Ear Neoplasms / secondary. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / secondary. Ear, External. Facial Neoplasms / pathology. Humans. Male

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  • (PMID = 17319999.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Mseddi M, Dammak A, Jellouli M, Ghorbel S, Bouassida S, Marrekchi S, Zahaf A, Turki H: [Profile of basal cell carcinomas of the scalp after radiotherapy for tinea capitis (about 63 cases)]. Rev Med Liege; 2006 Oct;61(10):724-7
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  • [Title] [Profile of basal cell carcinomas of the scalp after radiotherapy for tinea capitis (about 63 cases)].
  • [Transliterated title] Profil des carcinomes basocellulaires du cuir chevelu secondaires a une radiothérapie pour teigne (a propos de 63 cas).
  • The induction of basal cell carcinoma (BCC) of the scalp by X-ray therapy for tinea capitis is well known.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Head and Neck Neoplasms / etiology. Neoplasms, Radiation-Induced / etiology. Scalp. Skin Neoplasms / etiology. Tinea Capitis / radiotherapy

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  • (PMID = 17209506.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Belgium
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59. Chen WL, Li JS, Yang ZH, Huang ZQ, Wang JU, Zhang B: Two submental island flaps for reconstructing oral and maxillofacial defects following cancer ablation. J Oral Maxillofac Surg; 2008 Jun;66(6):1145-56
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  • [Title] Two submental island flaps for reconstructing oral and maxillofacial defects following cancer ablation.
  • PURPOSE: The purpose of this study was to assess the reliability of 2 patterns of submental island flaps--the facial-submental artery island flap and the reverse facial-submental artery island flap--used for reconstruction of oral and maxillofacial defects following cancer ablation.
  • PATIENTS AND METHODS: Thirty-eight soft tissue defects were repaired with facial-submental artery island flaps and reverse facial-submental artery island flaps following cancer surgery.
  • The primary lesions included squamous cell carcinoma of the tongue (8 cases), buccal mucosa (16), floor of the mouth (4), lower gingiva (3), oropharynx (2); recurrent squamous cell carcinoma of the palate (3); and basal cell carcinoma of the facial skin (2).
  • The size of the skin paddle varied from a minimum of 4 cm x 8 cm to a maximum of 5 cm x 15 cm.
  • [MeSH-major] Chin / surgery. Facial Neoplasms / surgery. Mouth Neoplasms / surgery. Skin Transplantation / methods. Surgical Flaps / blood supply
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Face / blood supply. Fatal Outcome. Female. Humans. Male. Middle Aged. Neck / blood supply. Neck / surgery. Neoplasm Staging. Oral Surgical Procedures / methods. Reconstructive Surgical Procedures / methods. Retrospective Studies

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  • (PMID = 18486779.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] United States
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60. Asuquo ME, Agweye P, Ugare G, Ebughe G: Basal cell carcinoma in five albino Africans from the south-eastern equatorial rain forest of Nigeria. Int J Dermatol; 2007 Jul;46(7):754-6
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  • [Title] Basal cell carcinoma in five albino Africans from the south-eastern equatorial rain forest of Nigeria.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the white population and occurs infrequently in dark-pigmented individuals.
  • Albinism is an established risk factor for skin cancer in black Africans.
  • METHODS: We evaluated the clinical histories and treatment outcomes of patients with a histologic diagnosis of BCC, who were seen at the University of Calabar Teaching Hospital, Calabar, Nigeria between January 2000 and December 2004.
  • The five patients ranged in age from 21 to 60 years (mean, 38 years); six BCCs (67%) were located in the head and neck area, and three tumors (33%) involved the upper limbs.
  • [MeSH-major] Albinism / complications. Carcinoma, Basal Cell / etiology. Skin Neoplasms / etiology. Ultraviolet Rays / adverse effects

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  • (PMID = 17614810.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. King R, Page RN, Googe PB, Mihm MC Jr: Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous nevus. Mod Pathol; 2005 Oct;18(10):1397-401
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  • The anatomical sites included trunk (7), head and neck (6) and upper extremity (3).
  • The clinical diagnosis was variable and included lentigo maligna, atypical nevus, pigmented basal cell carcinoma, seborrheic keratosis and lentigo.
  • The diagnosis of melanoma was more easily recognized in the complete excision specimens.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Hutchinson's Melanotic Freckle / diagnosis. Lentigo / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15976811.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Veness MJ: High-risk cutaneous squamous cell carcinoma of the head and neck. J Biomed Biotechnol; 2007;2007(3):80572
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  • [Title] High-risk cutaneous squamous cell carcinoma of the head and neck.
  • Nonmelanoma skin cancers (squamous cell and basal cell carcinomas) occur at an epidemic rate in many countries with the worldwide incidence increasing.
  • The sun-exposed head and neck are the most frequent sites for these cancers to arise and in most patients diagnosed with a cutaneous squamous cell carcinoma, local treatment is usually curative.
  • However, a subset is diagnosed with a high-risk cutaneous squamous cell carcinoma.
  • Despite treatment, many patients developing metastatic cutaneous squamous cell carcinoma experience mortality and morbidity usually as a consequence of uncontrolled metastatic nodal disease.
  • It is therefore important that clinicians treating nonmelanoma skin cancers have an understanding and awareness of these high-risk patients.

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  • (PMID = 17541471.001).
  • [ISSN] 1110-7243
  • [Journal-full-title] Journal of biomedicine & biotechnology
  • [ISO-abbreviation] J. Biomed. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1874675
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63. Balle JR, Hasselager T: [Kaposi's sarcoma interpreted as haematoma]. Ugeskr Laeger; 2010 Aug 30;172(35):2388-9
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  • Kaposi's sarcoma is a frequent skin cancer in HIV-positive patients, but is relatively uncommon in HIV-negative and non-immune compromised patients.
  • We present a case of Kaposi's sarcoma of the face and scalp in a HIV-negative male with previous facial basal cell carcinoma.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Sarcoma, Kaposi / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Facial Neoplasms / diagnosis. Facial Neoplasms / pathology. Humans. Male. Scalp / pathology

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  • (PMID = 20825744.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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64. Pua VS, Huilgol S, Hill D: Evaluation of the treatment of non-melanoma skin cancers by surgical excision. Australas J Dermatol; 2009 Aug;50(3):171-5
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  • [Title] Evaluation of the treatment of non-melanoma skin cancers by surgical excision.
  • A retrospective study of all non-melanoma skin cancers excised by two dermatologists at a private practice in 2004 (excluding Mohs microscopic surgery cases) was conducted.
  • For basal cell cancers, the incomplete excision rate was 1.54% (5/324) and for squamous cell cancers including Bowen's disease the incomplete excision rate was 3.9% (5/129).
  • Although a significant proportion of the tumours were from the head and neck region (45.9%), this study demonstrated that careful patient selection, experience of the surgeon and adherence to recommended excision margins can achieve a favourable incomplete excision rate.
  • [MeSH-major] Neoplasm, Residual / pathology. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Surgical Procedures, Operative / methods
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Biopsy, Needle. Carcinoma, Basal Cell / mortality. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Cohort Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis. Reoperation. Retrospective Studies. Risk Assessment. Sex Factors. South Australia. Survival Analysis

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  • (PMID = 19659977.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Australia
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65. Nakai N, Takenaka H, Hamada S, Kishimoto S: Identical p53 gene mutation in malignant proliferating trichilemmal tumour of the scalp and small cell carcinoma of the common bile duct: the necessity for therapeutic caution? Br J Dermatol; 2008 Aug;159(2):482-5
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  • [Title] Identical p53 gene mutation in malignant proliferating trichilemmal tumour of the scalp and small cell carcinoma of the common bile duct: the necessity for therapeutic caution?
  • [MeSH-major] Genes, p53. Head and Neck Neoplasms / genetics. Neoplasms, Basal Cell / genetics. Point Mutation. Scalp. Skin Neoplasms / genetics

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  • (PMID = 18510672.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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66. Piesold JU, Vent S, Krüger R, Pistner H: [Treatment results after surgery for basal cell carcinomas of the head and neck region taking into consideration various reconstruction techniques]. Mund Kiefer Gesichtschir; 2005 May;9(3):143-51
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  • [Title] [Treatment results after surgery for basal cell carcinomas of the head and neck region taking into consideration various reconstruction techniques].
  • BACKGROUND: Basal cell carcinomas are the most frequently occurring malignant tumors in the white population.
  • PATIENTS AND METHOD: All cases of basal cell carcinoma treated at the department for oral and maxillofacial and regional plastic surgery of the HELIOS hospital in Erfurt between 1976 and 2003 were analyzed and partly reexamined in a retrospective study.
  • RESULTS: A total of 648 patients with 765 basal cell carcinomas were treated.
  • In 64% of the cases the basal cell carcinomas were nodular, in 16% infiltrative.
  • DISCUSSION: If an infiltrative basal cell carcinoma is suspected or insufficient radical primary surgery is presumed, plastic reconstruction should be postponed until free margins can be confirmed histologically.
  • The functional and aesthetic quality of reconstruction was better using pedicled flaps (90%) and primary closure (86%) than using free skin transplants (30-54%).
  • Nevertheless, free skin flaps and epitheses were found to be well accepted by the reexamined patients.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Neoplasms, Radiation-Induced / surgery. Skin Neoplasms / surgery. Sunlight / adverse effects
  • [MeSH-minor] Aged. Dermatologic Surgical Procedures. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Orbit Evisceration. Outcome and Process Assessment (Health Care). Retrospective Studies. Skin / pathology. Surgical Flaps

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  • [Cites] Facial Plast Surg. 1997 Apr;13(2):79-82 [9243982.001]
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  • (PMID = 15719264.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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67. Tuncer S, Kuvat SV, Kabakas F, Ermis I: Expansion of skin by a lipoma and its use as a full-thickness skin graft. Plast Reconstr Surg; 2006 Mar;117(3):1058-9
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  • [Title] Expansion of skin by a lipoma and its use as a full-thickness skin graft.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Lipoma / surgery. Neoplasms, Multiple Primary / surgery. Scalp. Skin Neoplasms / surgery. Skin Transplantation

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  • (PMID = 16525329.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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68. Chatterjee S, Mott JH, Dickson S, Kelly CG: Extensive basal cell carcinoma of the forehead and anterior scalp: use of helical tomotherapy as a radiotherapy treatment modality. Br J Radiol; 2010 Jun;83(990):538-40
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  • [Title] Extensive basal cell carcinoma of the forehead and anterior scalp: use of helical tomotherapy as a radiotherapy treatment modality.
  • [MeSH-major] Carcinoma, Basal Cell / radiotherapy. Head and Neck Neoplasms / radiotherapy. Radiotherapy, Conformal / methods. Scalp. Skin Neoplasms / radiotherapy

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  • [Cites] Int J Radiat Oncol Biol Phys. 2002 Feb 1;52(2):553-9 [11872304.001]
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  • (PMID = 20505036.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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69. Leibovitch I, Huilgol SC, Selva D, Lun K, Richards S, Paver R: Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery. J Am Acad Dermatol; 2005 Feb;52(2):295-300
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  • [Title] Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is reported to have a high rate of recurrence with standard wide local excision.
  • METHODS: This prospective, multi-center case series included all patients in Australia treated with MMS for MAC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
  • RESULTS: There were 44 cases; most of them (90.9%) were located in the head and neck area.
  • In 32.5% of cases the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Australia / epidemiology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Child. Databases, Factual. Diagnostic Errors. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prospective Studies. Retrospective Studies. Treatment Outcome


70. Omari AK, Khammash MR, Matalka I: Skin cancer trends in northern Jordan. Int J Dermatol; 2006 Apr;45(4):384-8
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  • [Title] Skin cancer trends in northern Jordan.
  • BACKGROUND: The Jordan Cancer Registry was established in 1996, since which time all cases of cancer have been reported and registered.
  • We have used this registry to perform the first analysis of skin cancer in northern Jordan and to compare our findings with those of published reports from other regions.
  • METHODS: All histopathologically proven cases of skin cancer, reported during the years 1997 through 2001, were reviewed.
  • RESULTS: A total of 272 cases of malignant skin tumors were diagnosed between the years 1997 and 2001.
  • Basal cell carcinoma (BCC) was the commonest type, representing 52.9% of all skin cancers.
  • Squamous cell carcinoma (SCC) comprised 26.4% of the total, its age-adjusted incidence rate per 100,000 of population being 14.2 for males and 6.18 for females. the incidence rate increased in males and decreased in females during the study period.
  • The head and neck region was the commonest site affected by both types of cancer.
  • Malignant melanoma (MM) comprised 11.39% of all skin cancer cases, with a female to male ratio of 1.2 : 1.
  • CONCLUSIONS: In Jordan, sun-related skin cancers have relatively low incidences and a rather stable pattern, compared with other areas with similar climate and skin phenotypes.
  • [MeSH-major] Skin Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Female. Head and Neck Neoplasms / epidemiology. Humans. Jordan / epidemiology. Male. Melanoma / epidemiology. Middle Aged. Registries. Retrospective Studies. Sex Distribution

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  • (PMID = 16650163.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Caresana G, Giardini R: Dermoscopy-guided surgery in basal cell carcinoma. J Eur Acad Dermatol Venereol; 2010 Dec;24(12):1395-9
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  • [Title] Dermoscopy-guided surgery in basal cell carcinoma.
  • BACKGROUND: In basal cell carcinoma (BCC), excision margins between 3 and 10 mm, according to site, size, borders, previous treatment and histology, can allow for radical excision in at least 95% of cases.
  • METHODS: A prospective study was performed of 200 consecutive BCCs of the head and neck removed with 2-mm dermoscopically detected excision margins.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Dermoscopy. Skin Neoplasms / surgery

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  • [Copyright] © 2010 The Authors. Journal compilation © 2010 European Academy of Dermatology and Venereology.
  • (PMID = 20384678.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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72. Brewster DH, Bhatti LA, Inglis JH, Nairn ER, Doherty VR: Recent trends in incidence of nonmelanoma skin cancers in the East of Scotland, 1992-2003. Br J Dermatol; 2007 Jun;156(6):1295-300
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  • [Title] Recent trends in incidence of nonmelanoma skin cancers in the East of Scotland, 1992-2003.
  • BACKGROUND: Historically, ascertainment of nonmelanoma skin cancer (NMSC) by cancer registries in the U.K. has been shown to be incomplete in several studies.
  • However, recent evidence suggesting that almost all clinically diagnosed NMSCs are verified histologically, coupled with the increasing availability of electronic histopathology data to cancer registries, raises the possibility that this situation may have improved.
  • OBJECTIVES: To assess recent trends in incidence of the main types of NMSC and carcinoma in situ (CIS) of the skin in Scotland.
  • METHODS: The study was restricted to selected health board areas in the East of Scotland for which pathology data have been used routinely to support cancer registration since the early 1990s.
  • Incident cases of squamous cell carcinoma (SCC) of the skin, CIS of the skin, and first ever basal cell carcinoma (BCC) were extracted from the Scottish Cancer Registry covering the period of diagnosis 1992-2003.
  • Sex-specific, age-standardized and age-specific incidence rates were calculated for four consecutive 3-year periods of diagnosis.
  • The percentage distribution of SCC, BCC and CIS of the skin by anatomical site and sex was calculated for the period of diagnosis 1997-2003.
  • Age-adjusted rates of SCC, first ever BCC, and CIS of the skin have all increased significantly in both sexes between 1992 and 2003 (all P < 0.001), with EAPCs ranging in magnitude from +1.4% (first ever BCC in males) to +5.1% (CIS in males).
  • The majority of lesions arose on the head and neck area, with the exception of CIS, which in females was more commonly located on the limbs.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 17535229.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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73. Mendenhall WM, Amdur RJ, Hinerman RW, Cognetta AB, Mendenhall NP: Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck. Laryngoscope; 2009 Oct;119(10):1994-9
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  • [Title] Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck.
  • OBJECTIVES/HYPOTHESIS: To discuss the role of radiotherapy (RT) in the treatment of cutaneous squamous and basal cell carcinomas of the head and neck.
  • CONCLUSIONS: Definitive RT is useful for treating early-stage skin cancers where resection would result in a significant cosmetic and/or functional deficit.
  • [MeSH-major] Carcinoma, Basal Cell / radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Head and Neck Neoplasms / radiotherapy. Skin Neoplasms / radiotherapy

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  • (PMID = 19688856.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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74. Arits AH, van de Weert MM, Nelemans PJ, Kelleners-Smeets NW: Pain during topical photodynamic therapy: uncomfortable and unpredictable. J Eur Acad Dermatol Venereol; 2010 Dec;24(12):1452-7
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  • A total of 141 lesions in 108 patients were included, treated from November 2008 until June 2009 with PDT for superficial basal cell carcinoma, Bowen's disease (BD) or actinic keratosis (AK).
  • Factors associated with higher PI-NRS scores were treatment of AK or BD, tumour localization in the head/neck region, patient's age over 70, Fitzpatrick skintype I/II, photosensitizer 5-aminolevulinic acid and use of oral analgesics.
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Prospective Studies. Skin Diseases / drug therapy

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  • [Copyright] © 2010 The Authors. Journal compilation © 2010 European Academy of Dermatology and Venereology.
  • (PMID = 20456543.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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75. Trabelsi A, Stita W, Gharbi O, Kanani N, Sriha B, Korbi S: Malignant proliferating trichilemmal tumor of the scalp: a case report. Dermatol Online J; 2008;14(8):11
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  • BACKGROUND: Malignant proliferating trichilemmal tumor is a rare skin tumor that affects mainly older women.
  • It mimicks differential squamous cell carcinoma and its biological behavior is unpredictable.
  • After wide excision, long term clinical follow up of the patient for early diagnosis of metastases is judicious.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Neoplasms, Basal Cell / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Carcinoma / diagnosis. Cell Division. Diagnosis, Differential. Female. Humans. Keratinocytes / pathology

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  • (PMID = 19061571.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Watson A, Kent P, Alam M, Paller AS, Umbach DM, Yoon JW, Iannaccone PM, Walterhouse DO: GLI1 genotypes do not predict basal cell carcinoma risk: a case control study. Mol Cancer; 2009 Nov 30;8:113
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  • [Title] GLI1 genotypes do not predict basal cell carcinoma risk: a case control study.
  • BACKGROUND: Susceptibility to basal cell carcinoma results from complex interactions between ultraviolet radiation exposure and genetic factors.
  • We determined whether GLI1 polymorphisms were risk factors for developing basal cell carcinoma, either alone or in combination with patterns of past sun exposure, and whether there were functional differences among different GLI1 haplotypes.
  • RESULTS: GLI1 genotypes at c.2798 and c.3298 from 201 basal cell carcinoma patients were compared to 201 age and sex-matched controls.
  • However, the odds of developing basal cell carcinoma on the trunk compared to the head/neck appeared somewhat lower with carriers of the c.3298GC than the CC genotype.
  • There was no evidence for interactions between skin type, childhood sunburning, average adult sun exposure, adult sunbathing, or intermittency of sun exposure and GLI1 haplotype.
  • Additionally, we found no significant differences in transcription activation or cell transforming ability among the four GLI1 haplotypes.
  • CONCLUSION: These results suggest that different GLI1 genotypes alone or in combination with past sun exposure patterns as assessed in this study do not affect basal cell carcinoma risk.

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  • (PMID = 19948058.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2789726
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77. Cernea CR, Ferraz AR, de Castro IV, Sotto MN, Logullo AF, Potenza AS, Bacchi CE: Evaluation of basement membrane status in aggressive skin carcinomas with skull base invasion: a case-control study. Ann Diagn Pathol; 2005 Jun;9(3):130-3
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  • [Title] Evaluation of basement membrane status in aggressive skin carcinomas with skull base invasion: a case-control study.
  • Some skin carcinomas may be very aggressive.
  • In this study, the status of BM in invasion was evaluated in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) with skull base invasion, and it was compared with tumor's good outcome.
  • [MeSH-major] Basement Membrane / pathology. Carcinoma, Basal Cell / secondary. Carcinoma, Squamous Cell / secondary. Skin Neoplasms / pathology. Skull Base / pathology. Skull Base Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Collagen Type IV / metabolism. Combined Modality Therapy. Head and Neck Neoplasms / pathology. Humans. Immunohistochemistry. Neoplasm Invasiveness. Retrospective Studies. Single-Blind Method

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  • (PMID = 15944953.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type IV
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78. Shumaker PR, Lane K, Harford R: Linear unilateral basal cell nevus: a benign follicular hamartoma simulating multiple basal cell carcinomas. Cutis; 2006 Aug;78(2):122-4
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  • [Title] Linear unilateral basal cell nevus: a benign follicular hamartoma simulating multiple basal cell carcinomas.
  • We report a case of linear unilateral basal cell nevus (LBCN) occurring on the left lateral neck and left posterior shoulder of a 23-year-old woman.
  • LBCN is a rare benign follicular hamartoma that must be distinguished from the more aggressive unilateral and segmental variant of nevoid basal cell carcinoma syndrome (NBCCS) and the linear variant of BCC.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Hamartoma / pathology. Nevus / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans


79. Rhee JS, Davis-Malesevich M, Logan BR, Neuburg M, Burzynski M, Nattinger AB: Behavior modification and risk perception in patients with nonmelanoma skin cancer. WMJ; 2008 Apr;107(2):62-8
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  • [Title] Behavior modification and risk perception in patients with nonmelanoma skin cancer.
  • CONTEXT: Nonmelanoma skin cancer (NMSC) is the most common cancer among humans, yet risk perceptions and preventive health behaviors in those who survive this cancer are relatively unknown.
  • These patients were all adults, were fluent in English, and had NMSC of the head and neck.
  • Predictor factors associated with increased sun-protective behavior included poor skin tanning ability, summer season, no employment, less comorbid conditions, and previous NMSC treatment.
  • As for risk perception, respondents thought they were more likely than someone similar to themselves to develop future NMSCs but thought they had similar risks of developing melanoma or other non-skin cancers (P<0.001).
  • Increased patient education of associated cancer risks with NMSC is warranted.
  • Increased patient education of associated cancer risks with NMSC is warranted.
  • [MeSH-major] Behavior Therapy. Carcinoma, Basal Cell / prevention & control. Carcinoma, Basal Cell / psychology. Health Behavior. Perception. Risk. Skin Neoplasms / prevention & control. Skin Neoplasms / psychology

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  • (PMID = 18593080.001).
  • [ISSN] 1098-1861
  • [Journal-full-title] WMJ : official publication of the State Medical Society of Wisconsin
  • [ISO-abbreviation] WMJ
  • [Language] eng
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB009557; United States / NCI NIH HHS / CA / R03 CA108271; United States / NCI NIH HHS / CA / R03 CA108271
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS428241; NLM/ PMC3590063
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80. Zghal M, Triki S, Elloumi-Jellouli A, Jbali A, Gargouri H, Benmously R, Souissi R, Chedly I, Brahim EB, Ayed MB, Fenniche S, Mokhtar I: [Contribution of the cryosurgery in the management of xeroderma pigmentosum]. Ann Dermatol Venereol; 2010 Oct;137(10):605-9
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  • [Transliterated title] L'apport de la cryochirurgie dans la prise en charge du xeroderma pigmentosum.
  • BACKGROUND: Basal cell carcinoma (BCC) occurs frequently in young patients with xeroderma pigmentosum (XP).
  • Mean carcinoma size was 10mm.
  • CONCLUSION: Because of its simplicity, its good safety, its sparing of skin and its reliability of oncological outcome, cryosurgery is the treatment of choice for CBC in XP patients.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Cryosurgery / methods. Facial Neoplasms / surgery. Head and Neck Neoplasms / surgery. Skin Neoplasms / surgery. Xeroderma Pigmentosum / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Female. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Reoperation. Retrospective Studies. Young Adult

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  • [Copyright] Copyright © 2010. Published by Elsevier Masson SAS.
  • (PMID = 20932439.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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81. Leibovitch I, Huilgol SC, Selva D, Richards S, Paver R: Basal cell carcinoma treated with Mohs surgery in Australia I. Experience over 10 years. J Am Acad Dermatol; 2005 Sep;53(3):445-51
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  • [Title] Basal cell carcinoma treated with Mohs surgery in Australia I. Experience over 10 years.
  • BACKGROUND: Only a few prospective studies have been published on surgical treatments for cutaneous basal cell carcinoma (BCC).
  • METHOD: This prospective, multicenter case series included all patients in Australia treated with MMS for BCC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
  • Most of the tumors (98.3%) were on the head and neck area, most commonly on the nose (39%), cheek and maxilla (16.5%), periocular area (12.7%), and auricular region (11.4%).
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Maxillary Neoplasms / surgery. Mohs Surgery. Neoplasm Recurrence, Local / surgery. Nose Neoplasms / surgery. Skin Neoplasms / surgery

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  • (PMID = 16112351.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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82. Abdulla FR, Kerns MJ, Mutasim DF: Amelanotic lentigo maligna: a report of three cases and review of the literature. J Am Acad Dermatol; 2010 May;62(5):857-60
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  • BACKGROUND: Amelanotic lentigo maligna is not clinically suspected and is often mistaken for a basal cell carcinoma, squamous cell carcinoma, or dermatitis.
  • CONCLUSION: A high degree of clinical and histologic suspicion is required to make the diagnosis of this clinically nondescript neoplasm.
  • [MeSH-major] Hutchinson's Melanotic Freckle / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Female. Forearm. Humans. Keratosis, Actinic / diagnosis. Male. Middle Aged. Neck

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  • [Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 19766347.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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83. Bizakis JG, Manios A, Karatzanis AD, Drivas E, Malandrakis S: Giant cornu cutaneum. Otolaryngol Head Neck Surg; 2005 Oct;133(4):645
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  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 16213964.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Lindemalm-Lundstam B, Dalenbäck J: Prospective follow-up after curettage-cryosurgery for scalp and face skin cancers. Br J Dermatol; 2009 Sep;161(3):568-76
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  • [Title] Prospective follow-up after curettage-cryosurgery for scalp and face skin cancers.
  • BACKGROUND: Cryosurgery (CS) in the treatment of nonmelanoma skin cancers (NMSCs), especially in the face and on the scalp, has several advantages vs. other methods.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Cryosurgery / methods. Head and Neck Neoplasms / surgery. Scalp. Skin Neoplasms / surgery

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  • (PMID = 19624544.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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85. El Marakby HH, Naguib SF, El-Sawy Ael-H, Amin AA: Stepladder reconstructive options in post-ablative complex surgical defects in the head and neck. J Egypt Natl Canc Inst; 2008 Sep;20(3):253-61
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  • [Title] Stepladder reconstructive options in post-ablative complex surgical defects in the head and neck.
  • BACKGROUND: Reconstruction of head and neck defects can pose many challenges to the reconstructive head and neck surgeon.
  • AIM OF THE STUDY: The aim of the study is to evaluate different reconstructive options in complex defects of the head and neck region after resection of malignant tumours.
  • The feasibility of the reconstructive ladder starting from simple techniques such as local flaps and skin grafts up to free flaps will be assessed.
  • PATIENTS AND METHODS: In this study we evaluated different reconstructive procedures used in 50 patients with complex head and neck defects undertaken at the department of surgery at the National Cancer Institute between July 2003 and December 2007.
  • Most of the tumours were either squamous cell carcinoma (74 %) or Basal cell carcinoma (20 %).
  • We used local flaps and skin grafts in reconstruction in 36 % of cases and pedicled flaps in 32% while free flaps were used in 32 % of cases.
  • KEY WORDS: Head and neck reconstruction - Pedicled flaps - Free flaps.

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  • (PMID = 20424656.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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86. Lai SY, Weber RS: High-risk non-melanoma skin cancer of the head and neck. Curr Oncol Rep; 2005 Mar;7(2):154-8
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  • [Title] High-risk non-melanoma skin cancer of the head and neck.
  • High-risk non-melanoma skin cancer (NMSC) of the head and neck is difficult to manage, given its propensity for regional metastasis, perineural invasion, direct parotid invasion, and bony destruction.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Skin Neoplasms / therapy
  • [MeSH-minor] Anticarcinogenic Agents / therapeutic use. Carcinoma, Basal Cell / therapy. Carcinoma, Squamous Cell / therapy. Humans. Neoplasm Metastasis. Photochemotherapy. Precancerous Conditions / therapy. Risk

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  • (PMID = 15717950.001).
  • [ISSN] 1523-3790
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents
  • [Number-of-references] 35
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87. Onesti MG, Mazzocchi M, Scuderi N: Merkel cell carcinoma in the orbitopalpebral region. Scand J Plast Reconstr Surg Hand Surg; 2005;39(1):48-52
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  • [Title] Merkel cell carcinoma in the orbitopalpebral region.
  • Trabecular carcinoma is a rare cutaneous neuroendocrine carcinoma that probably originates from the Merkel cells that are usually found in the basal layer of the epidermis.
  • The treatment of Merkel cell carcinoma is controversial and there is no specific therapeutic protocol because of the small number of cases that have been published.
  • The procedures used to treat Merkel cell carcinoma must be tailored to minimise morbidity while maximising survival.

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  • (PMID = 15848965.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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88. Hoang MP, Dresser KA, Kapur P, High WA, Mahalingam M: Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol; 2008 Feb;21(2):178-85
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  • [Title] Microcystic adnexal carcinoma: an immunohistochemical reappraisal.
  • Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain.
  • In addition, a comparison with squamous cell carcinoma has not been reported previously.
  • In this study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell carcinoma, and eight squamous cell carcinoma of which five exhibited ductal differentiation.
  • We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative.
  • Forty percent of infiltrative basal cell carcinoma expressed CK7; while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories.
  • While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases.
  • Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10.
  • BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma.
  • In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation.
  • Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15+ and BerEP4+/-; thus, additional studies are needed to separate these two entities.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Skin Appendage / chemistry. Head and Neck Neoplasms / chemistry. Immunohistochemistry / methods. Skin Neoplasms / chemistry
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Humans. Keratin-15 / analysis. Male. Middle Aged


89. Malik V, Goh KS, Leong S, Tan A, Downey D, O'Donovan D: Risk and outcome analysis of 1832 consecutively excised basal cell carcinomas in a tertiary referral plastic surgery unit. J Plast Reconstr Aesthet Surg; 2010 Dec;63(12):2057-63
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  • [Title] Risk and outcome analysis of 1832 consecutively excised basal cell carcinomas in a tertiary referral plastic surgery unit.
  • BACKGROUND: Basal cell carcinomas are the most prevalent of all skin cancers worldwide and form the majority of the surgical workload for most modern cutaneous malignancy centres.
  • Primary surgical removal of basal cell carcinomas remains the gold standard of treatment but, despite almost two centuries of surgical experience, rates of incomplete surgical excision of up to 50% are still reported.
  • The aim of this study was to assess, quantify and perform comparative analysis of the outcomes and predictive factors of consecutive primarily-excised basal cell carcinomas in a tertiary centre over a six-year period.
  • METHODS: Retrospective audit was conducted on all patients who underwent surgical excision of basal cell carcinomas from January 2000 to December 2005.
  • RESULTS: One thousand eight hundred and thirty two basal cell carcinomas were excised from 1329 patients over the designated time period.
  • CONCLUSIONS: Overall basal cell carcinomas excision rates compared favourably with international reported standards but attention to a variety of surgical and histological risk factors may improve this further.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Skin Neoplasms / surgery

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  • [Copyright] Copyright © 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20226750.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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90. Walsh SN, Hurt MA, Santa Cruz DJ: Psoriasiform keratosis. Am J Dermatopathol; 2007 Apr;29(2):137-40
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  • There was, however, no known clinical diagnosis of psoriasis in any patient, neither at initial presentation nor on follow-up examination.
  • Other sites included the scalp, neck, shoulders, and back.
  • The mean age at diagnosis was 66.8 years.
  • The most common diagnoses, clinically, were seborrheic keratosis, followed by basal cell carcinoma, Bowen's disease, actinic (solar) keratosis, and squamous cell carcinoma, among others.
  • [MeSH-major] Keratosis, Seborrheic / pathology. Psoriasis / pathology. Skin / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lichenoid Eruptions / pathology. Lymphocytes / pathology. Male. Middle Aged. Neutrophils / pathology. Prospective Studies. Terminology as Topic. Time Factors

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  • (PMID = 17414434.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Nguyen TH: Mohs bashing out of hand. Plast Reconstr Surg; 2005 Jan;115(1):361-2
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  • [MeSH-minor] Ambulatory Surgical Procedures / adverse effects. Ambulatory Surgical Procedures / education. Ambulatory Surgical Procedures / psychology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Dermatology / education. Head and Neck Neoplasms / surgery. Humans. Outpatients / psychology. Patient Satisfaction. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Skin Neoplasms / surgery

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  • [CommentOn] Plast Reconstr Surg. 2004 Feb;113(2):774-5 [14758268.001]
  • (PMID = 15622305.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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92. Villalon-Lopez JS, Valle-Mejia CA, Patino-Lara A, Moreno-Perez BA, Munoz-Lopez JA, Alcantar-Andrade A: Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review. J Cancer Res Ther; 2006 Jul-Sep;2(3):140-3
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  • [Title] Supraestructure maxillectomy and orbital exenteration for treatment of basal cell carcinoma of inferior eyelid: case report and review.
  • Basal cell carcinoma (BCC) is the most frequent type of skin cancer in humans, with cumulative exposure to ultraviolet radiation as an important risk factor for development of illness such as severe solar burns during childhood or adolescence.
  • BCC is mainly located on sun-exposed sites, head and neck being the areas of more incidences; although nose, eyelids and periorbitary tissue are unfavorable due to cosmetic results that BCC involves.
  • Mohs' micrographic surgery is the standard treatment for all nonmelanoma skin cancers.
  • Orbital exenteration is also used for treatment of malignancies of ocular tissues, mainly squamous cell carcinoma, sebaceous cell carcinoma and BCC.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Maxilla / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 17998694.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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93. Betti R, Radaelli G, Bombonato C, Crosti C, Cerri A, Menni S: Anatomic location of Basal cell carcinomas may favor certain histologic subtypes. J Cutan Med Surg; 2010 Nov-Dec;14(6):298-302
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  • [Title] Anatomic location of Basal cell carcinomas may favor certain histologic subtypes.
  • BACKGROUND: Differences in age, site, and subtype exist in basal cell carcinoma (BCC).
  • The location was the head/neck (n  =  1,766), limbs (n  =  362), trunk (n  =  1,113), or genitals (n  =  13).
  • RESULTS: Prevalence of BCCs on the head/neck or chest/abdomen increased with age (p < .001).
  • The prevalence of superficial subtype was lower among BCCs on the head/neck than other locations (24.9% vs 64.4%, OR 0.18, 95% CI 0.16-0.21).
  • The prevalence of nodular or morpheic/infiltrative subtype was higher among BCCs on the head/neck than other locations, that is, 57.1% versus 29.2%, OR 3.23, 95% CI 2.79 to 3.74 (nodular) and 16.1% versus 4.0%, OR 4.56, 95% CI 3.42 to 6.08 (morpheic/infiltrative).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 21084023.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Hawayek LH, Mutasim DF: Myiasis in a giant squamous cell carcinoma. J Am Acad Dermatol; 2006 Apr;54(4):740-1
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  • [Title] Myiasis in a giant squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / complications. Head and Neck Neoplasms / complications. Myiasis / complications. Scalp. Skin Neoplasms / complications


95. Behroozan DS, Goldberg LH: Combined linear closure and Burow's graft for a dorsal nasal defect. Dermatol Surg; 2006 Jan;32(1):107-11
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  • An 80-year-old man with a history of nonmelanoma skin cancers of the head and neck presented for treatment of a basal cell carcinoma of the nose.
  • [MeSH-major] Nose Deformities, Acquired / surgery. Rhinoplasty / methods. Skin Transplantation. Suture Techniques
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell / surgery. Humans. Male. Nose Neoplasms / surgery. Postoperative Complications

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  • (PMID = 16393610.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Harris PJ, Takebe N, Ivy SP: Molecular conversations and the development of the hair follicle and basal cell carcinoma. Cancer Prev Res (Phila); 2010 Oct;3(10):1217-21
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  • [Title] Molecular conversations and the development of the hair follicle and basal cell carcinoma.
  • The understanding of the anatomy and development of fetal and adult hair follicles and the molecular study of the major embryonic pathways that regulate the hair follicle have led to exciting discoveries concerning the development of basal cell carcinoma (BCC).
  • Ptch1 deletion resulted in both an expansion of the stem cell niche and inhibition of cell differentiation.
  • In transformed hair follicles, IGFBP-2 mediates epidermal progenitor cell expansion.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Cell Transformation, Neoplastic. Hair Follicle / growth & development. Signal Transduction / physiology. Skin Neoplasms / pathology

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  • [Copyright] ©2010 AACR.
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  • (PMID = 20858758.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Insulin-Like Growth Factor Binding Protein 2
  • [Other-IDs] NLM/ NIHMS233639; NLM/ PMC2992967
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97. Taboada A, Prieto A, Couto I, Brea B, González E: [Invasive basal cell carcinoma of the scalp. A clinical case]. Neurocirugia (Astur); 2010 Oct;21(5):396-400
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  • [Title] [Invasive basal cell carcinoma of the scalp. A clinical case].
  • [Transliterated title] Carinoma basocelular invasivo de cuero cabelludo. Caso clínico.
  • Basal cell carcinoma is the most frequent skin malignant neoplasm, although it doesn't usually compromise a vital risk.
  • We present a 62 years old female operated several times because multifocal basal cell carcinoma on her scalp.
  • [MeSH-major] Brain Neoplasms. Carcinoma, Basal Cell. Head and Neck Neoplasms. Skin Neoplasms

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  • (PMID = 21042691.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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98. Bogeschdorfer F, Gronau S, Riechelmann H: [New substances in the therapy of head and neck cancer]. Laryngorhinootologie; 2006 Jul;85(7):520-9; quiz 530-1
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  • [Title] [New substances in the therapy of head and neck cancer].
  • During the last 3 years the FDA approved numerous innovative drugs for cancer therapy.
  • These new therapeutic tools may play a future part also in the therapy of head and neck cancer.
  • [MeSH-major] Head and Neck Neoplasms / drug therapy
  • [MeSH-minor] Administration, Oral. Aminoquinolines / administration & dosage. Aminoquinolines / adverse effects. Aminoquinolines / pharmacology. Aminoquinolines / therapeutic use. Angiogenesis Inhibitors / administration & dosage. Angiogenesis Inhibitors / therapeutic use. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Monoclonal / pharmacology. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Humanized. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / adverse effects. Antineoplastic Agents / pharmacology. Antineoplastic Agents / therapeutic use. Bevacizumab. Carcinoma, Basal Cell / drug therapy. Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / mortality. Cetuximab. Clinical Trials, Phase II as Topic. Clinical Trials, Phase III as Topic. Colorectal Neoplasms / drug therapy. Controlled Clinical Trials as Topic. Double-Blind Method. Erlotinib Hydrochloride. Fibroblast Growth Factor 7 / administration & dosage. Fibroblast Growth Factor 7 / adverse effects. Fibroblast Growth Factor 7 / pharmacology. Fibroblast Growth Factor 7 / therapeutic use. Humans. Infusions, Intravenous. Iodine Radioisotopes / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / mortality. Lymphatic Metastasis. Lymphoma, Non-Hodgkin / drug therapy. Lymphoma, Non-Hodgkin / radiotherapy. Ointments. Protein Kinase Inhibitors / therapeutic use. Quinazolines / administration & dosage. Quinazolines / adverse effects. Quinazolines / pharmacology. Quinazolines / therapeutic use. Radioimmunotherapy. Randomized Controlled Trials as Topic. Skin Neoplasms / drug therapy. Time Factors. United States. United States Food and Drug Administration

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  • (PMID = 16791768.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Iodine Radioisotopes; 0 / Ointments; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; 0 / iodine-131 anti-B1 antibody; 126469-10-1 / Fibroblast Growth Factor 7; 2S9ZZM9Q9V / Bevacizumab; 99011-02-6 / imiquimod; DA87705X9K / Erlotinib Hydrochloride; PQX0D8J21J / Cetuximab; S65743JHBS / gefitinib
  • [Number-of-references] 18
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99. Kishikawa M, Koyama K, Iseki M, Kobuke T, Yonehara S, Soda M, Ron E, Tokunaga M, Preston DL, Mabuchi K, Tokuoka S: Histologic characteristics of skin cancer in Hiroshima and Nagasaki: background incidence and radiation effects. Int J Cancer; 2005 Nov 10;117(3):363-9
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  • [Title] Histologic characteristics of skin cancer in Hiroshima and Nagasaki: background incidence and radiation effects.
  • Skin cancers, though rare in Japan, have reportedly been on the rise, but little else is known about epidemiologic features of different histologic types of skin cancer.
  • The Life Span Study cohort, which consists of 93,700 atomic-bomb survivors, many of whom were exposed to negligibly low radiation doses, and 26,600 people not exposed to radiation, enables a population-based study of spontaneous as well as radiation-related cancer risk.
  • Skin tumor incident cases diagnosed between 1958 and 1987 were ascertained by linkage to the Hiroshima and Nagasaki tumor registries augmented by searches of other data sources.
  • They identified 274 primary incident skin cancers, of which 106 were basal cell carcinoma (BCC), 81 were squamous cell carcinoma (SCC), and 14 were malignant melanomas.
  • BCCs were mainly on the head/neck (81%), whereas SCCs occurred most frequently on the arms/legs (45%) and head/neck (29%), consistent with the presumed role played by solar UV exposure in skin cancer.
  • The excess absolute risk of BCC per unit skin surface area related to atomic-bomb radiation exposure did not differ between UV-exposed and shielded parts of the body, suggesting the additivity of the radiation-related and background BCC risks.
  • [MeSH-major] Nuclear Warfare. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15900592.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CP / N01-CP-31012; United States / NCI NIH HHS / CP / N01-CP-71015
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radioactive Fallout
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100. Ram R, Saadat P, Peng D, Vadmal M: Case report and literature review: primary cutaneous carcinosarcoma. Ann Clin Lab Sci; 2005;35(2):189-94
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  • Primary carcinosarcomas of the skin are uncommon.
  • Most of these tumors were seen on the head and neck region of older individuals, both male and female.
  • Microscopically, the more common carcinoma component is a squamous cell carcinoma followed by basal cell carcinoma, whereas the most common sarcoma component is an osteosarcoma.
  • We report an example of this rare entity and speculate on its histogenesis in the skin.
  • [MeSH-major] Carcinosarcoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Humans. Male. Osteosarcoma / pathology

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  • (PMID = 15943184.001).
  • [ISSN] 0091-7370
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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