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1. Ahmed MM: Expression profile of apoptotic mediators and proliferative markers in oral squamous cell carcinoma. J Egypt Natl Canc Inst; 2009 Jun;21(2):85-92
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  • [Title] Expression profile of apoptotic mediators and proliferative markers in oral squamous cell carcinoma.
  • BACKGROUND: Oral squamous cell carcinoma (OSCC) represents a major health problem worldwide.
  • Beside the recent hypothesis of cancer stem cells, the consideration of its cell death and cell proliferation has emerged as important diagnostic and prognostic tools.
  • PURPOSE OD THE STUDY: Detection of the proportion of cell loss monitored by apoptosis-related genes, p53, p21 and Bcl2, and their relationship to the pathological proliferation parameter, PCNA in OSCC.
  • Furthermore, discussion of the hypothesis of cancer stem cell biology in OSCC would be anticipated.
  • On the other hand, variable profile patterns of the investigated indicators existed, where PCNA positively immunostaining cells was 100%while P21 recorded the higher percentage of negatively immunoreactive cells (42.9%).
  • A common trait for the studied cell cycle indicators was that the basal and suprabasal epithelial cells as well as the peripheral cells of the invading nests were the harbor of immunoreactivity.
  • CONCLUSIONS: Assessment of the studied cell cycle regulators may be valuable to judge tumorigenesis of OSCC.
  • Furthermore, deregulation of cell cycle control might aid in the attainment of genetic changes in normal stem cells to be altered to cancer stem cells.
  • [MeSH-major] Apoptosis. Apoptosis Regulatory Proteins / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Cell Proliferation. Mouth Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Cell Cycle. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Female. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. Male. Middle Aged. Paraffin Embedding. Proliferating Cell Nuclear Antigen / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Stromal Cells / metabolism. Stromal Cells / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 21057559.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Biomarkers, Tumor; 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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2. Nalwoga H, Arnes JB, Wabinga H, Akslen LA: Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer. Br J Cancer; 2010 Jan 19;102(2):369-75
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  • [Title] Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer.
  • BACKGROUND: Putative breast cancer stem cells might express surface markers such as aldehyde dehydrogenase 1 (ALDH1) and BMI-1 proteins.
  • The aim of this study was to explore the expression of these proteins in breast cancers from an African population and their associations with the basal-like phenotype (BLP) and other molecular characteristics.
  • METHODS: We analysed 192 paraffin-embedded breast carcinoma samples by tissue microarrays and immunohistochemical methods.
  • On the other hand, BMI-1 expression was associated with low histological grade (P=0.004) and ER positivity (P=0.001).
  • CONCLUSION: There was a high prevalence of ALDH1 expression among breast carcinomas and associations with basal markers and features of aggressive tumours.
  • Studies are required to elucidate the importance of these findings for improved understanding of breast cancer biology.

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  • (PMID = 20010944.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BMI1 protein, human; 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; EC 1.2.1.- / aldehyde dehydrogenase 1; EC 1.2.1.3 / Aldehyde Dehydrogenase; EC 1.2.1.36 / Retinal Dehydrogenase; EC 6.3.2.19 / Polycomb Repressive Complex 1
  • [Other-IDs] NLM/ PMC2816658
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3. Maruyama M, Matsunaga T, Harada E, Ohmori S: Comparison of basal gene expression and induction of CYP3As in HepG2 and human fetal liver cells. Biol Pharm Bull; 2007 Nov;30(11):2091-7
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  • [Title] Comparison of basal gene expression and induction of CYP3As in HepG2 and human fetal liver cells.
  • Human fetal liver (HFL) cell culture was initiated from a pool of six normal human liver tissues.
  • On the other hand, CYP3A4, CYP3A5, and CYP3A7 mRNA expression levels in HepG2 cells were increased from 2- to 3-fold by treatment with DEX and RIF.
  • [MeSH-major] Carcinoma, Hepatocellular / enzymology. Cytochrome P-450 Enzyme System / biosynthesis. Hepatocytes / enzymology. Liver Neoplasms / enzymology
  • [MeSH-minor] Aryl Hydrocarbon Hydroxylases. Cell Line, Tumor. Cytochrome P-450 CYP3A. Dexamethasone / pharmacology. Enzyme Induction / drug effects. Fetus. Formazans / metabolism. Gene Expression Regulation, Enzymologic / drug effects. Humans. Isoenzymes / biosynthesis. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Tetrazolium Salts / metabolism. Time Factors

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  • (PMID = 17978482.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Formazans; 0 / Isoenzymes; 0 / RNA, Messenger; 0 / Tetrazolium Salts; 23305-68-2 / MTT formazan; 7S5I7G3JQL / Dexamethasone; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / CYP3A protein, human; EC 1.14.14.1 / CYP3A5 protein, human; EC 1.14.14.1 / CYP3A7 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A
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4. Paavilainen V, Tuominen J, Aho VV, Saari KM: Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland. Eur J Ophthalmol; 2007 Jul-Aug;17:494-500

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  • [Title] Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland.
  • : . PURPOSE: Basal cell carcinoma (BCC) is the most common skin cancer of the eyelid, showing an increasing incidence in the white population.
  • In this study 61 patients (31.9%) developed other malignancies than the BCC of the eyelid including 28 patients (14.7 %) with carcinoma in other locations than skin.
  • On the other hand, BCCs of the eyelid should not be underestimated because of the rather high total recurrence rate.

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  • (PMID = 28221540.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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5. Chuprov IN: [Immunomorphological features of cutaneous basal-cell carcinoma]. Vopr Onkol; 2008;54(6):715-9
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  • [Title] [Immunomorphological features of cutaneous basal-cell carcinoma].
  • An immunohistochemical study of p53, Ki-67, bcl-2, CK-8 and collagen IV was conducted in 47 basal-cell carcinomas (BCC) to ascertain their prognostic value.
  • There was a distinct correlation between p53 and Ki-67 levels, on the one hand, and the main clinico-morphological features of BCC (r=0.63-0.78), on the other.
  • High anti-apoptotic bcl-2 expression in superficial BCC (36.85%) was matched by its decrease in nodular carcinoma and was minimal in high grade infiltrative BCC (13.24%).
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / pathology. Skin Neoplasms / chemistry. Skin Neoplasms / pathology

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  • (PMID = 19241845.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type IV; 0 / Keratin-8; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53
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6. Sane RS, Buckley DJ, Buckley AR, Nallani SC, Desai PB: Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells. Drug Metab Dispos; 2008 May;36(5):946-54
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  • Previously we observed that the antiestrogens tamoxifen and 4-hydroxytamoxifen (4OHT) induce CYP3A4 in primary human hepatocytes and activate human pregnane X receptor (PXR) in cell-based reporter assays.
  • Second, in LS174T colon carcinoma cells, which were observed to have significantly lower PXR expression relative to human hepatocytes, neither tamoxifen nor 4OHT induced CYP3A4.
  • We then used cell-based reporter assay to evaluate the effects of other receptors such as glucocorticoid receptor GR alpha and estrogen receptor ER alpha on the transcriptional activation of PXR.
  • On the other hand, the presence of ER alpha inhibited PXR-mediated basal activation of CYP3A4 promoter, possibly via competing for common cofactors such as steroid receptor coactivator 1 and glucocorticoid receptor interacting protein 1.
  • [MeSH-minor] Cell Line, Tumor. Cells, Cultured. Estrogen Receptor alpha / metabolism. Hepatocytes / drug effects. Hepatocytes / metabolism. Humans. RNA, Messenger / metabolism. RNA, Small Interfering / genetics. Receptors, Glucocorticoid / metabolism. Transfection

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  • (PMID = 18299335.001).
  • [ISSN] 1521-009X
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Receptors, Glucocorticoid; 0 / Receptors, Steroid; 0 / pregnane X receptor; 094ZI81Y45 / Tamoxifen; 17197F0KYM / afimoxifene; EC 1.14.13.67 / CYP3A4 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A
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7. Celis JE, Gromov P, Cabezón T, Moreira JM, Friis E, Jirström K, Llombart-Bosch A, Timmermans-Wielenga V, Rank F, Gromova I: 15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma. Mol Cell Proteomics; 2008 Oct;7(10):1795-809
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  • [Title] 15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma.
  • Molecular profiling technologies, on the other hand, subdivide breast tumors into five subtypes, basal-like, luminal A, luminal B, normal breast tissue-like, and ERBB2-positive, that have different prognostic characteristics.
  • Here we reiterate our strategy to reveal apocrine cell markers and present novel data, based on the analysis of a considerably larger number of samples, establishing that IACs correspond to a distinct molecular subtype of breast carcinomas characterized by the expression of 15-prostaglandin dehydrogenase alone or in combination with a novel form of acyl-CoA synthetase medium-chain family member 1 (ACSM1).
  • Moreover we show that 15-prostaglandin dehydrogenase is not expressed by other breast cancer types as determined by gel-based proteomics and immunohistochemistry analysis and that antibodies against this protein can identify IACs in an unbiased manner in a large breast cancer tissue microarray making them potentially useful as a diagnostic aid.

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  • (PMID = 18632593.001).
  • [ISSN] 1535-9484
  • [Journal-full-title] Molecular & cellular proteomics : MCP
  • [ISO-abbreviation] Mol. Cell Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.1.1.- / Hydroxyprostaglandin Dehydrogenases; EC 1.1.1.141 / 15-hydroxyprostaglandin dehydrogenase; EC 6.2.1.- / ACSM1 protein, human; EC 6.2.1.- / Coenzyme A Ligases
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8. Habib SL, Simone S, Barnes JJ, Abboud HE: Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors. Mol Cancer; 2008 Jan 24;7:10
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  • Loss of heterozygosity (LOH) at the TSC2 locus has been detected in TSC-associated renal cell carcinoma (RCC) and in RCC in the Eker rat.
  • Loss of function mutations of OGG1 also occurs in human kidney clear cell carcinoma and may contribute to tumorgenesis.
  • On the other hand, 8-oxo-dG levels were highest in the medulla, which expressed the lowest levels of OGG1.
  • The basal levels of 8-oxo-dG were also higher in both cortex and medulla of Eker rats compared to wild type rats.
  • In addition, the predominant expression of OGG1 in the cortex and its decreased expression and activity in the Eker rat may account for the predominant cortical localization of renal cell carcinoma.

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  • (PMID = 18218111.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P50 DK061597; United States / NIDDK NIH HHS / DK / R37 DK33665
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / OGG1 protein, rat; G9481N71RO / Deoxyguanosine
  • [Other-IDs] NLM/ PMC2265742
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9. Erba P, Farhadi J, Wettstein R, Arnold A, Harr T, Pierer G: Morphoeic basal cell carcinoma of the face. Scand J Plast Reconstr Surg Hand Surg; 2007;41(4):184-8
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  • [Title] Morphoeic basal cell carcinoma of the face.
  • The morphoeic (or sclerosing) basal cell carcinoma (mBCC) is the most aggressive subtype, as it spreads into the dermis beyond the clinically visible or palpable borders, making complete excision difficult.

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  • (PMID = 17701732.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Wettstein R, Erba P, Farhadi J, Kalbermatten DF, Arnold A, Haug M, Pierer G: Incomplete excision of basal cell carcinoma in the subunits of the nose. Scand J Plast Reconstr Surg Hand Surg; 2008;42(2):92-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incomplete excision of basal cell carcinoma in the subunits of the nose.
  • Reconstructive procedures after resection of nasal basal cell carcinoma (BCC) vary depending on the subunit involved.

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  • (PMID = 18335353.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Pham TT, Selim MA, Burchette JL Jr, Madden J, Turner J, Herman C: CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol; 2006 Feb;33(2):123-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD10 expression in trichoepithelioma and basal cell carcinoma.
  • BACKGROUND: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC).
  • On the other hand, expression of CD10 by basaloid cells was identified in 20 (87%) cases of BCC.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / metabolism. Neoplasms, Basal Cell / metabolism. Neprilysin / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 16420307.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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12. Yazici AC, Unal S, Ikizoglu G, Kokturk A, Baz K, Cinel L, Koca A: Superficial basal cell carcinoma of the scalp mimicking seborrhoeic dermatitis. Scand J Plast Reconstr Surg Hand Surg; 2006;40(1):54-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superficial basal cell carcinoma of the scalp mimicking seborrhoeic dermatitis.
  • Superficial basal cell carcinomas (BCC) comprise 9% to 11% of BCC, and are commonly found on the trunk or limbs.

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  • (PMID = 16428215.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Rupprecht M, Mensing CH, Barvencik F, Ittrich H, Heiland M, Rueger JM, Amling M, Pogoda P: [Skeletal and dermatological manifestations of the nevoid Basal cell carcinoma syndrome (Gorlin-Goltz syndrome). Results of 8 patients in 12 years]. Rofo; 2007 Jun;179(6):618-26
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  • [Title] [Skeletal and dermatological manifestations of the nevoid Basal cell carcinoma syndrome (Gorlin-Goltz syndrome). Results of 8 patients in 12 years].
  • PURPOSE: In 1960 Gorlin and Goltz defined the nevoid basal cell carcinoma syndrome (NBCCS, Gorlin-Goltz Syndrome) as a syndrome comprising multiple basal cell carcinoma, odontogenic keratocysts, and skeletal anomalies.
  • Nevoid basal cell carcinoma syndrome was diagnosed in the event of two major or one major and two minor criteria.
  • The major criteria are more than 2 basal cell carcinoma, odontogenic keratocysts, three or more palmar pits, and calcification of the falx cerebri.
  • The major criteria with the most frequency were the basal cell carcinoma (6 patients) and the odontogenic keratocysts (5 patients), followed by the calcification of the falx cerebri and palmoplantar pits (4 patients).
  • [MeSH-major] Basal Cell Nevus Syndrome / radiography. Bone Neoplasms / radiography. Carcinoma, Basal Cell / radiography. Skin Neoplasms / radiography

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  • (PMID = 17492539.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 42
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14. Hüsler R, Schlittler FL, Kreutziger J, Streit M, Banic A, Schöni-Affolter F, Hunger RE, Constaninescu MA: Staged surgical therapy of basal cell carcinoma of the head and neck region: an evaluation of 500 procedures. Swiss Med Wkly; 2008 Dec 13;138(49-50):746-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Staged surgical therapy of basal cell carcinoma of the head and neck region: an evaluation of 500 procedures.
  • QUESTIONS UNDER STUDY / PRINCIPLES: The surgical therapy of basal cell carcinoma (BCC) is especially demanding in the facial area.
  • CONCLUSIONS: The staged surgical therapy of basal cell carcinoma evaluated here offers a series of advantages in respect of patient comfort and safety and economy, while allowing precise histological safety with low infection rates and reliable long-term results.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Skin Neoplasms / surgery

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  • [CommentIn] Swiss Med Wkly. 2010 Jan 9;140(1-2):31-2; author reply 32 [20669073.001]
  • (PMID = 19130328.001).
  • [ISSN] 1424-7860
  • [Journal-full-title] Swiss medical weekly
  • [ISO-abbreviation] Swiss Med Wkly
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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15. Paavilainen V, Tuominen J, Aho VV, Saari KM: Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland. Eur J Ophthalmol; 2007 Jul-Aug;17(4):494-500

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland.
  • PURPOSE: Basal cell carcinoma (BCC) is the most common skin cancer of the eyelid, showing an increasing incidence in the white population.
  • In this study 61 patients (31.9%) developed other malignancies than the BCC of the eyelid including 28 patients (14.7 %) with carcinoma in other locations than skin.
  • On the other hand, BCCs of the eyelid should not be underestimated because of the rather high total recurrence rate.
  • [MeSH-major] Carcinoma, Basal Cell / therapy. Eyelid Neoplasms / therapy. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 17671921.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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16. Erba P, Wettstein R, Rieger UM, Beltraminelli H, Pierer G, Kalbermatten DF: Reducing the learning curve for the treatment of morphoeic (sclerosing) basal cell carcinoma of the face. Scand J Plast Reconstr Surg Hand Surg; 2008;42(3):122-6
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  • [Title] Reducing the learning curve for the treatment of morphoeic (sclerosing) basal cell carcinoma of the face.
  • The treatment of morphoeic (or sclerosing) basal cell carcinoma (mBCC) of the face is associated with high rates of incomplete excision and recurrence.

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  • (PMID = 18470787.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
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17. Jirakulaporn T, Mathew J, Lindgren BR, Dudek AZ: Efficacy of capecitabine in secondary prevention of skin cancer in solid organ-transplanted recipients (OTR). J Clin Oncol; 2009 May 20;27(15_suppl):1519

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of capecitabine in secondary prevention of skin cancer in solid organ-transplanted recipients (OTR).
  • Topical 5% 5-FU has been used to successfully treat squamous cell carcinoma (SCC) in situ and actinic keratosis (AK).
  • METHODS: OTR who developed recurrent skin cancers, SCC, and/or basal cell carcinoma (BCC), were given low-dose capecitabine 1g/m2 divided in two daily doses, day 1-14 of 21-day treatment cycle.
  • Six of the total of 14 patients experienced grade 3/4 toxicities, including mucositis (2), hand-foot syndrome (3), fatigue (2), nausea (1), diarrhea (2), hyperuricemia (1), and anemia (1), and all six needed capecitabine dose reduction or stopping therapy.

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  • (PMID = 27964327.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Kuroda N, Hirano K, Ohara M, Hirouchi T, Mizuno K, Kubo A, Enzan H: Adenoid basal carcinoma arising in the cervical polyp: an immunohistochemical study of stromal cells. Med Mol Morphol; 2007 Jun;40(2):112-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid basal carcinoma arising in the cervical polyp: an immunohistochemical study of stromal cells.
  • Adenoid basal carcinomas of the uterine cervix are uncommon neoplasms and generally run a favorable clinical course.
  • Although it is well known that these tumors do not evoke the stromal reaction, we immunohistochemically examined a stromal reaction in a case of adenoid basal carcinoma.
  • Histological examination revealed the finding of adenoid basal carcinoma.
  • On the other hand, alpha-smooth muscle actin-positive and h-caldesmon-negative stromal cells, namely myofibroblasts, were completely absent in the stroma of tumor center.
  • Finally, our preliminary report suggests that the decrease of CD34-positive fibroblasts in adenoid basal carcinoma may show an early stromal reaction to tumor invasion.
  • Gynecologists and pathologists should bear in mind that adenoid basal carcinoma may arise in a cervical polyp.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Basal Cell / pathology. Polyps / pathology. Stromal Cells / metabolism. Uterine Cervical Neoplasms / pathology

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  • [Cites] Int J Gynecol Pathol. 2002 Oct;21(4):327-46 [12352182.001]
  • [Cites] Am J Surg Pathol. 1999 Oct;23(10):1308-9 [10524536.001]
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  • [Cites] Virchows Arch. 2002 Dec;441(6):564-8 [12461613.001]
  • [Cites] Med Mol Morphol. 2006 Dec;39(4):209-13 [17187184.001]
  • [Cites] Histopathology. 2002 Sep;41(3):185-207 [12207781.001]
  • [Cites] Adv Anat Pathol. 2002 Sep;9(5):290-300 [12195218.001]
  • [Cites] Int J Gynecol Pathol. 1997 Oct;16(4):307-12 [9421068.001]
  • [Cites] Med Mol Morphol. 2006 Sep;39(3):161-3 [16998627.001]
  • [Cites] Med Electron Microsc. 2000;33(4):241-5 [11810481.001]
  • (PMID = 17572848.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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19. Kikkawa Y, Sudo R, Kon J, Mizuguchi T, Nomizu M, Hirata K, Mitaka T: Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule. Exp Cell Res; 2008 Aug 15;314(14):2579-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule.
  • Laminins are a diverse group of alpha/beta/gamma heterotrimers formed from five alpha, three beta and three gamma chains; they are major components of all basal laminae (BLs).
  • Little is known, however, about the expression and function of laminins containing the alpha 5 chain in human hepatocellular carcinoma (HCC).
  • On the other hand, laminin alpha 5 deposition was observed throughout all HCCs tested, regardless of tumor grade.
  • In HCC cell lines, laminin alpha 5 heterotrimerized with beta and gamma chains and was secreted into the culture media.
  • In this regard, alpha 3 beta 1/alpha 6 beta 1 integrins and Lutheran/basal cell adhesion molecule (Lu/B-CAM) were expressed in HCC cells.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Cell Adhesion Molecules / metabolism. Integrins / metabolism. Laminin / metabolism. Liver Neoplasms / pathology. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Animals. Cell Adhesion. Female. Humans. Immunohistochemistry. Integrin alpha6beta4 / metabolism. Liver / metabolism. Lutheran Blood-Group System. Male. Middle Aged. Protein Transport. Rats. Rats, Sprague-Dawley

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  • (PMID = 18635166.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCAM protein, human; 0 / Cell Adhesion Molecules; 0 / Integrin alpha6beta4; 0 / Integrins; 0 / Laminin; 0 / Lutheran Blood-Group System; 0 / Neoplasm Proteins; 0 / laminin alpha5
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20. Ali F, Brown A, Gottwald L, Thomas J: Basal cell carcinoma with matrical differentiation in a transplant patient: a case report and review of the literature. J Cutan Pathol; 2005 Jul;32(6):445-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma with matrical differentiation in a transplant patient: a case report and review of the literature.
  • The presence of shadow cells within tumor islands composed of follicular germinative cells of an otherwise classic basal cell carcinoma (BCC) has been considered as a distinct diagnostic category of BCC with matrical differentiation.
  • METHODS: A 58-year-old male cardiac transplant patient with a nodule on the dorsum of left hand was studied.
  • RESULTS: The H&E-stained sections of the hand lesion revealed multiple nodular masses of basaloid follicular germinative cells.
  • [MeSH-major] Carcinoma, Basal Cell / immunology. Carcinoma, Basal Cell / pathology. Heart Transplantation. Immunocompromised Host. Skin Neoplasms / immunology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Hair Diseases / pathology. Hand / pathology. Humans. Male. Middle Aged. Pilomatrixoma / pathology

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  • (PMID = 15953381.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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21. Tehrani H, Walls J, Cotton S, Sassoon E, Hall P: Spectrophotometric intracutaneous analysis in the diagnosis of basal cell carcinoma: a pilot study. Int J Dermatol; 2007 Apr;46(4):371-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spectrophotometric intracutaneous analysis in the diagnosis of basal cell carcinoma: a pilot study.
  • BACKGROUND: The SIAscope is a portable imaging device that uses a hand-held unit to emit light of varying wavelengths when placed on the skin.
  • The components of skin absorb light to known extents and any reflected light is received by the hand-held unit.
  • The SIAscope has not, however, been previously investigated for nonmelanoma skin cancer diagnosis.
  • METHODS: Having gained ethical approval, 20 consecutive lesions were scanned using the SIAscope, and the images were examined for features that may be indicative of nonmelanoma skin cancer.
  • RESULTS: The findings of branched vessels and vascular "flare" were indicative of a lesion being a basal cell carcinoma.
  • CONCLUSIONS: This pilot study implies that the SIAscope may indeed provide an accurate method for basal cell carcinoma diagnosis by identifying features specific for such lesions.
  • Further studies to investigate nonmelanoma skin cancer diagnosis, and to explore any potential to differentiate between basal cell carcinomas and squamous cell carcinomas and between superficial and thicker basal cell carcinomas by the SIAscope, are warranted.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Dermoscopy. Image Processing, Computer-Assisted. Skin Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Humans. Melanoma / classification. Melanoma / diagnosis. Melanoma / pathology. Pilot Projects

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  • (PMID = 17442075.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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22. Downs N, Parisi A: Measurements of the anatomical distribution of erythemal ultraviolet: a study comparing exposure distribution to the site incidence of solar keratoses, basal cell carcinoma and squamous cell carcinoma. Photochem Photobiol Sci; 2009 Aug;8(8):1195-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Measurements of the anatomical distribution of erythemal ultraviolet: a study comparing exposure distribution to the site incidence of solar keratoses, basal cell carcinoma and squamous cell carcinoma.
  • The UV exposures were compared with existing data detailing the anatomical distribution of basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and solar keratoses (SK).
  • Surface UV exposures to unprotected skin surfaces have been presented for each of the face, neck, arm, hand and leg assessing a total of 1453 body sites (2491 measurements).
  • The median anatomical UV expressed relative to the horizontal plane ambient UV for each of the face, neck, forearm, hand and leg regions of the body varied from 26%, 23%, 13%, 30% and 12% respectively in the 0 degrees-30 degrees SZA range; 39%, 36%, 17%, 35% and 23% in the 30 degrees-50 degrees SZA range; and 48%, 59%, 41%, 42% and 47% in the 50 degrees-80 degrees SZA range.
  • Detailed positions of UV exposure measured over the face, neck, arm, hand and leg were more closely related to NMSC incidence data for the face and upper limbs.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Keratosis / epidemiology. Skin / pathology. Ultraviolet Rays
  • [MeSH-minor] Arm / pathology. Arm / radiation effects. Australia / epidemiology. Dose-Response Relationship, Radiation. Environmental Exposure. Face / pathology. Face / radiation effects. Hand / pathology. Hand / radiation effects. Humans. Incidence. Leg / pathology. Leg / radiation effects. Neck / pathology. Neck / radiation effects

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  • (PMID = 19639123.001).
  • [ISSN] 1474-905X
  • [Journal-full-title] Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • [ISO-abbreviation] Photochem. Photobiol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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23. Onesti MG, Mazzocchi M, Scuderi N: Merkel cell carcinoma in the orbitopalpebral region. Scand J Plast Reconstr Surg Hand Surg; 2005;39(1):48-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma in the orbitopalpebral region.
  • Trabecular carcinoma is a rare cutaneous neuroendocrine carcinoma that probably originates from the Merkel cells that are usually found in the basal layer of the epidermis.
  • The treatment of Merkel cell carcinoma is controversial and there is no specific therapeutic protocol because of the small number of cases that have been published.
  • The procedures used to treat Merkel cell carcinoma must be tailored to minimise morbidity while maximising survival.

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  • (PMID = 15848965.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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24. Baba M, Durdu M, Seçkin D: A useful alternative approach for the treatment of well-demarcated Basal cell carcinoma: surgical excision and margin control with tzanck smear test. Dermatol Surg; 2010 May;36(5):659-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A useful alternative approach for the treatment of well-demarcated Basal cell carcinoma: surgical excision and margin control with tzanck smear test.
  • OBJECTIVE: To analyze the accuracy of the Tzanck smear test (TST) for margin control in surgery for well-demarcated basal cell carcinoma (BCC).
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Skin / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cheek. Cytodiagnosis / methods. Female. Forehead. Hand. Humans. Intraoperative Period. Male. Middle Aged. Nose Neoplasms / pathology. Nose Neoplasms / surgery. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 20384747.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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25. Iamshanov VA, Anisimov VV: [Pre- and early natal exposure to geomagnetic field as risk for melanoma and basal cell skin tumors]. Vopr Onkol; 2005;51(3):366-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pre- and early natal exposure to geomagnetic field as risk for melanoma and basal cell skin tumors].
  • Histories of 173 male and female patients with melanoma and basal cell skin tumors (BCST) were followed to elucidate the influence of pre- and early natal exposure to geomagnetic field (GMF) on future incidence of cancer.
  • A positive correlation was established between exposure to GMF during critical months of prenatal period, on the one hand, and melanoma detection, on the other.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Magnetics / adverse effects. Melanoma / etiology. Prenatal Exposure Delayed Effects. Skin Neoplasms / etiology

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  • (PMID = 16279104.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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26. Emanuel PO, Rudikoff D, Phelps RG: Aggressive squamous cell carcinoma in Kindler syndrome. Skinmed; 2006 Nov-Dec;5(6):305-7
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  • [Title] Aggressive squamous cell carcinoma in Kindler syndrome.
  • A 57-year-old Hispanic man with a personal and family history of bullae and photosensitivity presented with a fungating, ulcerated squamous cell carcinoma on his left hand (Figure 1).
  • Extensive histologic evaluation of the specimen obtained following left arm amputation and lymph node dissection showed moderate-to-poorly differentiated deeply invasive squamous cell carcinoma.
  • Two of 3 axillary lymph nodes were positive for metastatic carcinoma.
  • Electron microscopy illustrated extensive reduplication of the basement membrane, with loops, curls, and free extensions of the basal lamina in the superficial dermis; reduced numbers of hemidesmosomes and anchoring fibrils; and a basement membrane focally devoid of basal cells (Figure 4).
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Epidermolysis Bullosa / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Hand / pathology. Humans. Male. Middle Aged. Syndrome


27. Cavadas PC, Landin L, Ibañez J: Bilateral hand transplantation: result at 20 months. J Hand Surg Eur Vol; 2009 Aug;34(4):434-43
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  • [Title] Bilateral hand transplantation: result at 20 months.
  • On November 2006, a bilateral hand allotransplantation was performed for a 47-year-old female who had suffered radiocarpal amputations 28 years before.
  • In addition the patient developed a factitious visual disorder and a facial basal cell carcinoma.
  • Functionally, at 20 months, the patient had a Hand Registry Functional Score of 69 (good), and a DASH score of 19.
  • [MeSH-major] Amputation, Traumatic / surgery. Blast Injuries / surgery. Hand Injuries / surgery. Hand Transplantation
  • [MeSH-minor] Arthrodesis / methods. Cicatrix / surgery. Dominance, Cerebral / physiology. Drug Therapy, Combination. Evoked Potentials, Motor. Evoked Potentials, Somatosensory / physiology. Female. Follow-Up Studies. Graft Rejection / drug therapy. Graft Rejection / pathology. Hand / innervation. Hand / pathology. Hand Strength / physiology. Histocompatibility Testing. Humans. Immunosuppressive Agents / administration & dosage. Immunosuppressive Agents / adverse effects. Magnetic Resonance Imaging. Middle Aged. Motor Cortex / physiopathology. Osteotomy / methods. Physical Therapy Modalities. Postoperative Complications / pathology. Postoperative Complications / radiography. Postoperative Complications / rehabilitation. Postoperative Complications / surgery. Range of Motion, Articular / physiology. Reoperation / methods. Skin / pathology. Tendon Transfer / methods. Tissue and Organ Harvesting / methods

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  • (PMID = 19395533.001).
  • [ISSN] 2043-6289
  • [Journal-full-title] The Journal of hand surgery, European volume
  • [ISO-abbreviation] J Hand Surg Eur Vol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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28. Oster-Schmidt C, Dirschka T: Therapy of cutaneous squamous cell carcinoma in two retirement home residents. J Dtsch Dermatol Ges; 2005 Sep;3(9):705-8
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  • [Title] Therapy of cutaneous squamous cell carcinoma in two retirement home residents.
  • The incidence of cutaneous squamous cell carcinomas (SCC) has been increasing by about 5% per year of the past 40 years in a population which is growing continuously older and as such presents a growing therapeutic challenge.
  • We report on two elderly female residents of a retirement home with histologically confirmed SCC on the back of the hand.
  • Imiquimod 5% cream was approved last year for the treatment of superficial basal cell carcinoma.
  • [MeSH-major] Adjuvants, Immunologic / therapeutic use. Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / therapy. Hand Dermatoses / therapy. Skin Neoplasms / therapy. Surgical Flaps

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  • (PMID = 16189865.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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29. Hsieh PC, Chen YK, Tsai KB, Shieh TY, Chang YY, Chang JG, Wu HL, Lin SF: Expression of BUBR1 in human oral potentially malignant disorders and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Feb;109(2):257-67
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  • [Title] Expression of BUBR1 in human oral potentially malignant disorders and squamous cell carcinoma.
  • The aim of the present study was to examine the immunohistochemical expression of BUBR1 protein for human oral squamous cell carcinogenesis.
  • STUDY DESIGN: A total of 120 samples of squamous cell carcinoma (SCC, n = 43) and 5 types of potentially malignant disorders (PMDs: oral epithelial dysplasia, n = 11; hyperkeratosis/epithelial hyperplasia, n = 20; lichen planus, n = 16; submucous fibrosis, n = 19; and verrucous hyperplasia, n = 11) of human oral mucosa (1991-2001) from our institution were retrieved and immunohistochemical staining were performed.
  • RESULTS: BUBR1 staining was detected at the basal and suprabasal layers in 75 (97.4%) of 77 samples of PMD and 43 (100%) of 43 samples of SCC of oral mucosa but was absent in all samples of normal oral mucosa (n = 9) and fibrous hyperplasia (n = 9).
  • Moreover, the expression of oral SCC was significantly higher as compared respectively with the 5 types of oral PMD; on the other hand, BUBR1 expression of verrucous hyperplasia was significantly higher than that of the other 4 types of PMD of oral mucosa (P < .001).
  • These also hypothesize that BUBR1 protein is a putative biomarker for human oral squamous cell carcinogenesis.
  • [MeSH-major] Carcinoma, Squamous Cell / enzymology. Mouth Neoplasms / enzymology. Precancerous Conditions / enzymology. Protein-Serine-Threonine Kinases / biosynthesis. Spindle Apparatus / enzymology
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Biomarkers, Tumor. Case-Control Studies. Cell Cycle Proteins / biosynthesis. Cell Cycle Proteins / genetics. Cell Transformation, Neoplastic / chemistry. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Epithelial Cells / enzymology. Epithelial Cells / pathology. Female. Humans. Hyperplasia / enzymology. Hyperplasia / genetics. Immunoenzyme Techniques. Lichen Planus, Oral / enzymology. Lichen Planus, Oral / genetics. Male. Middle Aged. Mouth Mucosa / enzymology. Mouth Mucosa / pathology. Oral Submucous Fibrosis / enzymology. Oral Submucous Fibrosis / genetics. Warts / enzymology. Warts / genetics. Young Adult

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19926498.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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30. Takemura M, Morimura K, Yoshida K, Fujiwara Y: [Four resected cases with basaloid carcinoma of esophagus--comparison of 5-FU-related enzymes (thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT)) between basaloid carcinoma and squamous cell carcinoma]. Gan To Kagaku Ryoho; 2010 Nov;37(11):2143-6
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  • [Title] [Four resected cases with basaloid carcinoma of esophagus--comparison of 5-FU-related enzymes (thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT)) between basaloid carcinoma and squamous cell carcinoma].
  • We reported herein four resected cases with basaloid carcinoma of the esophagus and measured the activity of 5-FU related enzymes (TS, DPD, OPRT) in cancer tissue.
  • These activities compared with those in squamous cell carcinoma.
  • Only one case was diagnosed as basaloid carcinoma by preoperative biopsy specimen at endoscopic examination.
  • On the other hand, a lymphatic invasion was detected in one case, and venous invasion in two, respectively.
  • DPD activity and OPRT activity showed no difference between squamous cell carcinoma and basaloid carcinoma.
  • On the other hand, the TS activity was significantly higher in basaloid carcinoma.
  • From the standpoint of 5-FU-related enzyme activities, basaloid carcinoma possibly has more resistance to 5-FU than squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / enzymology. Carcinoma, Squamous Cell / enzymology. Dihydrouracil Dehydrogenase (NADP) / metabolism. Esophageal Neoplasms / enzymology. Orotate Phosphoribosyltransferase / metabolism. Thymidylate Synthase / metabolism

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  • (PMID = 21084814.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; EC 1.3.1.2 / Dihydrouracil Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; EC 2.4.2.10 / Orotate Phosphoribosyltransferase; U3P01618RT / Fluorouracil
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31. Yang YF, Li H, Xu XQ, Diao YT, Fang XQ, Wang Y, Zhao DL, Wu K, Li HQ: An expression of squamous cell carcinoma antigen 2 in peripheral blood within the different stages of esophageal carcinogenesis. Dis Esophagus; 2008;21(5):395-401
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  • [Title] An expression of squamous cell carcinoma antigen 2 in peripheral blood within the different stages of esophageal carcinogenesis.
  • The malignant transformation of esophageal mucosa is a progressive process, which includes basal cell hyperplasia, dysplasia, carcinoma in situ, and invasive esophageal squamous cell carcinoma (ESCC).
  • The objectives of this study were to prove the relationship of squamous cell carcinoma antigen 2 (SCCA2) mRNA expression in peripheral blood with non-malignant lesion, premalignant lesion, and carcinoma of the esophagus at the same assay, as well as to evaluate whether or not SCCA2 mRNA expression in peripheral blood may be a biomarker for monitoring the premalignant lesion of the disease.
  • The subjects consisted of 50 patients with basal cell hyperplasia, 50 patients with dysplasia, 50 patients with ESCC (12 carcinoma in situ, 38 carcinoma in invasive stage), and 50 controls who were pathologically diagnosed to be normal and whose esophageal mucosa were stained brown by iodine.
  • All the subjects are residents of Feicheng, China, which is considered an area with a high incidence of esophageal cancer.
  • In the cancer group, SCCA2 mRNA expression was also detected in 20 tissues of esophageal cancer.
  • By using the band intensity ratios of SCCA2 to beta-actin, with a positive cut-off value of > or = 0.4, the positive rates of the SCCA2 mRNA expression in peripheral blood were found to be 82% (41/50), 60% (30/50), 48% (24/50), and 36% (18/50) in the cancer, dysplasia, basal cell hyperplasia, and control groups, respectively.
  • The positive rate of the cancer group was significantly different from the three other groups (P < 0.05), and there was also a significant difference in the SCCA2 mRNA expression between the dysplasia group and the control group (chi(2)=5.769, P= 0.016).
  • In the multinomial logistic regression analysis, the odds ratios (ORs) were 1.71 [95% confidence interval (95% CI), 0.73-3.99] in the basal cell hyperplasia group, 2.77 (95% CI, 1.14-6.71) in the dysplasia group, and 7.87 (95% CI, 2.88-21.55) in the cancer group after being adjusted for age, gender, smoking index, drinking index, and family history of esophageal cancer.
  • By using a positive cut-off value of > or = 0.4, the testing sensitivities in the basal cell hyperplasia, dysplasia, and cancer groups were found to be 48%, 60%, and 82%, respectively, with the same testing specificity at 64%.
  • On the other hand, SCCA2 mRNA expression in peripheral blood had a 97.5% agreement with that in tissue, and there was a significant correlation between the ELISA SCCA2 levels in the serum and the SCCA2 mRNA expression levels in the peripheral blood (r= 0.80, P= 0.01).
  • The results indicate that SCCA2 mRNA expression in peripheral blood is linked with the different stages of esophageal pathological changes, despite the fact that SCCA2 mRNA was not a biomarker for screening early esophageal cancer.

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  • (PMID = 19125792.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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32. Verma AK, Wheeler DL, Aziz MH, Manoharan H: Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. Mol Carcinog; 2006 Jun;45(6):381-8
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  • [Title] Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.
  • PKC isoforms are differentially expressed in proliferative (basal layer) and nonproliferative compartments (spinous, granular, cornified layers), which exhibit divergence in their roles in the regulation of epidermal cell proliferation, differentiation, and apoptosis.
  • PKCepsilon is mostly localized in the proliferative basal layers.
  • PKC isozymes exhibit specificities in their signals to the development of skin cancer.
  • PKCepsilon, a calcium-insensitive PKC isoform mediates the induction of squamous cell carcinoma (SCC) elicited either by the DMBA-TPA protocol or by repeated exposures to ultraviolet radiation (UVR).
  • PKCepsilon overexpression, which sensitizes skin to UVR-induced carcinogenesis, suppresses UVR-induced sunburn (apoptotic) cell formation, and enhances both UVR-induced levels of TNFalpha and hyperplasia.
  • UVR-induced sunburn cell formation is mediated by Fas/Fas-L and TNFalpha NFR1 extrinsic apoptotic pathways.
  • It appears that PKCepsilon sensitizes skin to the development of SCC by UVR by transducting signals, which inhibit apoptosis on one hand, and enhances proliferation of preneoplastic cells on the other hand.
  • [MeSH-major] Carcinoma, Squamous Cell / enzymology. Protein Kinase C-epsilon / metabolism. Skin Neoplasms / enzymology

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  • (PMID = 16683253.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA102431; United States / NCI NIH HHS / CA / CA35368
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.13 / Protein Kinase C-epsilon; EC 4.1.1.17 / Ornithine Decarboxylase; NI40JAQ945 / Tetradecanoylphorbol Acetate
  • [Number-of-references] 41
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33. Gasparian NA, Pozharisskiĭ KM, Zharinov GM, Vinokurov VL, Kuznetsova ME, Neklasova NIu: [Immunohistochemical study of the predictive value of oncoproteins p53, HER-2 and c-myc during radiotherapy for squamous cell carcinoma of the cervix]. Vopr Onkol; 2007;53(4):439-44
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  • [Title] [Immunohistochemical study of the predictive value of oncoproteins p53, HER-2 and c-myc during radiotherapy for squamous cell carcinoma of the cervix].
  • Out of 80 patients with squamous cell cervical carcinoma (stage II-III), p53 expression was observed in 30% of tumors prior to treatment and 49% in the course of radiotherapy.
  • A correlation between degree of p53 expression before treatment, on the one hand, and overall and recurrence-free survival, on the other, was identified: high expression of mutated gene-suppressor p53 was 53% while for absence or low expression, it rose to 67% (p=0.03).
  • Hence, p53 expression may be used as a predictive factor in radiotherapy for cervical carcinoma.
  • No correlation was found between p53 expression, on the one hand, and such basal clinico-morphological parameters as stage, morphological pattern and tumor cell differentiation, on the other.
  • HER2(3t) overexpression occurred in 2 (2.5%) which seems to point to its insignificant role in squamous cell cervical carcinoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / radiotherapy. Proto-Oncogene Proteins c-myc / metabolism. Receptor, ErbB-2 / metabolism. Tumor Suppressor Protein p53 / metabolism. Uterine Cervical Neoplasms / radiotherapy


34. Nassab R, Rayatt S, Peart F: Infected palmar pits: a rare presentation of Gorlin's syndrome. J Hand Surg Br; 2005 Oct;30(5):459-60
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  • This paper presents a rare hand presentation of Gorlin's Syndrome, also known as Naevoid Basal Cell Carcinoma Syndrome, which has not been reported previously.
  • This condition is an autosomal dominant, multisystem condition whose diagnosis is important to ensure further surveillance and treatment of features of the condition not routinely dealt with by hand surgeons.
  • However, hand surgeons should be aware of this condition and those parts of the syndrome which may present to them.
  • [MeSH-major] Basal Cell Nevus Syndrome / diagnosis. Cellulitis / etiology. Hand

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  • (PMID = 16055245.001).
  • [ISSN] 0266-7681
  • [Journal-full-title] Journal of hand surgery (Edinburgh, Scotland)
  • [ISO-abbreviation] J Hand Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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35. Boukamp P: UV-induced skin cancer: similarities--variations. J Dtsch Dermatol Ges; 2005 Jul;3(7):493-503
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  • [Title] UV-induced skin cancer: similarities--variations.
  • Skin cancer, the most common cancer world wide, encompasses different tumor entities, the keratinocyte-derived basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) as well as the neuroectodermal malignant melanoma (MM) and the neuroendocrine Merkel cell carcinomas (MCC).
  • This review, thus, aims, on the one hand to summarize the present knowledge without claiming completeness and, on the other hand, to provide information on the HaCaT in vitro skin carcinogenesis model that is used to evaluate the functional consequence of genetic aberrations believed to play a role in skin cancer development and progression.
  • [MeSH-minor] Carcinoma, Basal Cell / genetics. Carcinoma, Merkel Cell / genetics. Carcinoma, Squamous Cell / genetics. Cell Line, Tumor. Cell Transformation, Neoplastic / genetics. Chromosome Aberrations / radiation effects. Disease Progression. Humans. Melanoma / genetics. Skin / radiation effects

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  • (PMID = 15967008.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 78
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36. D'Arpa S, Cordova A, Moschella F: Further application of the bilobed flap: the split bilobed flap for reconstruction of composite posterior auricular and mastoid defects. J Plast Reconstr Aesthet Surg; 2006;59(12):1330-5
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  • It is in fact a shaded area with little aesthetic relevance and direct closure, skin grafting and even secondary healing are used for skin cancer defects repair.
  • On the other hand, cancers involving the postero-medial auricular surface, the retroauricular sulcus and the mastoid skin require wide and deep resections that involve the posterior auricular muscles and reach the perichondral and periosteal surfaces.
  • Two patients, both affected by basal cell carcinoma involving the posteromedial auricular surface and the mastoid skin have been treated with this flap.
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / surgery. Ear Neoplasms / surgery. Head and Neck Neoplasms / surgery. Humans. Male. Mastoid

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  • (PMID = 17113512.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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37. Boukamp P: Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis; 2005 Oct;26(10):1657-67
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  • [Title] Non-melanoma skin cancer: what drives tumor development and progression?
  • Non-melanoma skin cancer, i.e. basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent tumors and their number is still increasing worldwide.
  • Furthermore, immunosuppression in organ transplant patients strongly contributes to the increase in skin cancer incidence--being 65-250 times more frequent than in the general population.
  • BCC, on the other hand, may be less dependent on immune surveillance thereby underlining its different etiology.
  • However, the complexity of the genetic alterations (numerical and structural aberration profiles) in SCCs argues for several levels of genomic instability involved in the generation and progression of skin cancer.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 15905207.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 152
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38. Belmahi A, Oufkir A, Bron T, Ouezzani S: Reconstruction of cheek skin defects by the 'Yin-Yang' rotation of the Mustardé flap and the temporoparietal scalp. J Plast Reconstr Aesthet Surg; 2009 Apr;62(4):506-9
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  • MATERIAL AND METHODS: From September 2001 to April 2005, nine patients aged between 35 and 78 years old, with no facial skin laxity, have benefited from this technique to cover suborbital defects secondary to excision of basal cell carcinomas with a mean diameter of 6 cm.
  • [MeSH-minor] Adult. Aged. Carcinoma, Basal Cell / surgery. Esthetics. Facial Neoplasms / surgery. Female. Follow-Up Studies. Humans. Middle Aged. Scalp / surgery. Skin Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18162448.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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39. Hida Y, Kubo Y, Arase S: Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours. Br J Dermatol; 2009 Jun;160(6):1258-63
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  • METHODS: We investigated the activation of FGFR3 and OIS by mutation and immunohistochemical analysis in skin tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
  • On the other hand, almost all the seborrhoeic keratoses showed negative immunoreactivity for antiphoshohistone H2AX (gamma-H2AX) as a marker of OIS, but 17 of 22 cases (77%) of AK were moderately to strongly positive.
  • [MeSH-minor] Bowen's Disease / genetics. Carcinoma, Basal Cell / genetics. Carcinoma, Squamous Cell / genetics. Chi-Square Distribution. Humans. Keratosis, Actinic / genetics. Keratosis, Seborrheic / genetics. Point Mutation / genetics. Transcriptional Activation

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  • (PMID = 19298285.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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40. Bozkurt M, Kapi E, Kuvat SV, Ozekinci S: Current concepts in the management of Marjolin's ulcers: outcomes from a standardized treatment protocol in 16 cases. J Burn Care Res; 2010 Sep-Oct;31(5):776-80
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • Primary lesions were at the leg, gluteal region, thigh, scalp, trunk, and hand in four (25%), three (18.7%), two (12.5%), two (12.5%), three (18.7%), and two (12.5%) cases, respectively.
  • Squamous cell carcinoma was diagnosed in 14 cases (87.5%) and basal cell carcinoma in two cases (12.5%) postoperatively.
  • [MeSH-major] Burns / complications. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / surgery. Skin Neoplasms / etiology. Skin Neoplasms / surgery. Skin Ulcer / etiology. Skin Ulcer / surgery

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  • (PMID = 20661151.001).
  • [ISSN] 1559-0488
  • [Journal-full-title] Journal of burn care & research : official publication of the American Burn Association
  • [ISO-abbreviation] J Burn Care Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Kovacevic PT, Visnjic MM, Kovacevic TT, Radojkovic MR, Stojanovic MR: Extended orbital exenteration in the treatment of advanced periocular skin cancer with primary reconstruction with a galeacutaneous flap. Scand J Plast Reconstr Surg Hand Surg; 2009;43(6):325-9
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • [Title] Extended orbital exenteration in the treatment of advanced periocular skin cancer with primary reconstruction with a galeacutaneous flap.
  • Skin cancers (basal cell cancer and squamous cell skin cancer) arising in the periorbital region could present as invasive tumours infiltrating the orbit and orbital walls.

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  • (PMID = 19995251.001).
  • [ISSN] 1651-2073
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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42. Kansal A, Brueton L, Lahiri A, Lester R: Hypoplastic thumb in Gorlin's syndrome. J Plast Reconstr Aesthet Surg; 2007;60(4):440-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gorlin's syndrome or naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder that predisposes to basal cell carcinomas of the skin, ovarian fibromas, and medulloblastomas.
  • Gorlin's syndrome is characterized by the development of multiple jaw keratocysts and/or basal carcinomas.
  • Various hand deformities have been reported in patients with Gorlin's syndrome including short metacarpals, cutaneous syndactyly of the second and third fingers, and pre- or post-axial polydactyly, but hypoplasia of the thumb has not been reported previously.
  • However, they still needs a specialist input to give the patient an optimum function of the thumb and the hand.
  • [MeSH-major] Basal Cell Nevus Syndrome. Thumb / abnormalities

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  • (PMID = 17349603.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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43. Papadopoulos O, Konofaos P, Chrisostomidis C, Georgiou P, Frangoulis M, Champsas G, Betsi E, Zapantis-Fragos M: Orbitopalpebral repair after 835 excisions of malignant tumours. Scand J Plast Reconstr Surg Hand Surg; 2005;39(6):353-9
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  • Basal cell carcinoma (BCC) is the most common malignant tumour of the eyelids, and squamous cell carcinoma (SCC), mixed carcinomas or basosquamous cell carcinomas (BSC), and cutaneous melanomas (CM), also invade the eyelids and periocular zones.

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  • (PMID = 16298808.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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44. Lidman D, Niklasson M: Survival and function in patients with tumours of the head and neck operated on and reconstructed with free flaps. Scand J Plast Reconstr Surg Hand Surg; 2008;42(2):77-85
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  • The tumours were squamous cell carcinoma (SCC) 104 (80%), salivary gland cancer 13 (10%), sarcoma 5 (4%), basal cell carcinoma 4 (3%), and others 4 (3%).

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  • (PMID = 18335351.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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45. Boboridis KG, Dimitrakos SA, Georgiadis NS, Stangos NT: Combination of periocular myocutaneous flaps for one-stage reconstruction of extensive defects of the eyelid. Scand J Plast Reconstr Surg Hand Surg; 2005;39(2):100-3
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  • [Title] Combination of periocular myocutaneous flaps for one-stage reconstruction of extensive defects of the eyelid.
  • We present the reconstructive challenge after excision of a large periocular tumour in a patient who needed early visual rehabilitation.
  • The periocular full thickness deficit of his only sighted eye was reconstructed with a combination of periocular myocutaneous flaps and a free buccal mucosal graft.
  • Adequate functional and cosmetic results with early visual rehabilitation were achieved in a single procedure.

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  • (PMID = 16019737.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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46. Zalatnai A: Molecular aspects of stromal-parenchymal interactions in malignant neoplasms. Curr Mol Med; 2006 Sep;6(6):685-93
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  • Carcinomas are composed of parenchymal and stromal elements, and the malignant behavior is principally dictated by the cancer cells.
  • Cancer cells may alter their stroma by cell-to-cell contact, soluble factors or by modification of the extracellular matrix (ECM), they induce myofibroblast differentiation and govern the desmoplastic stroma reaction.
  • On the other hand, the stromal cells (especially the myofibroblasts) are able to modify the phenotype, invasiveness, metastatic capacity of carcinomas, typically promoting the progression.
  • Regarding pancreatic cancer, the pancreatic stellate cells (PSCs) seem to be the key elements in the cross-talk between the parenchymal cells and the desmoplastic stroma.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Cell Communication. Gene Expression Regulation, Neoplastic. Neoplasms / metabolism. Pancreatic Neoplasms / metabolism
  • [MeSH-minor] Cell Transformation, Neoplastic. Extracellular Matrix / metabolism. Extracellular Matrix / physiology. Humans. Macrophages / physiology. Models, Biological. Neoplasm Invasiveness. Stromal Cells / metabolism. Stromal Cells / physiology

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  • (PMID = 17022738.001).
  • [ISSN] 1566-5240
  • [Journal-full-title] Current molecular medicine
  • [ISO-abbreviation] Curr. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 108
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47. Fujita K, Miyamoto T, Okada Y, Ishikawa N, Saika S: Expression pattern of sonic hedgehog and effect of topical mitomycin C on its expression in human ocular surface neoplasms. Jpn J Ophthalmol; 2008 May-Jun;52(3):190-4
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  • METHODS: Conjunctival tissues obtained from two normal subjects, two patients with squamous cell carcinoma of the ocular surface (conjunctiva), and one patient with ocular epithelial dysplasia were used in this study.
  • RESULTS: Faint immunoreactivity for Shh was detected in basal epithelial cells of limbus, bulbar, and palpebral conjunctival epithelial cells.
  • On the other hand, squamous cell carcinoma cells markedly expressed Shh with positive staining for Patched 1(Ptc), the cell surface receptor of Shh.
  • A cell culture experiment was conducted to examine the effect of mitomycin C on Shh expression in a cultured squamous cell carcinoma cell line.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Conjunctival Neoplasms / drug therapy. Corneal Diseases / drug therapy. Hedgehog Proteins / metabolism. Mitomycin / therapeutic use

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  • (PMID = 18661269.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Hedgehog Proteins; 0 / SHH protein, human; 50SG953SK6 / Mitomycin
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48. Tilleman TR, Neumann MH, Smeets NW, Tilleman MM: Waste of skin in elliptical excision biopsy of non-melanomatous skin cancer. Scand J Plast Reconstr Surg Hand Surg; 2006;40(6):352-6
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • [Title] Waste of skin in elliptical excision biopsy of non-melanomatous skin cancer.

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  • (PMID = 17118900.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Henriksson TG, Nettelblad H: Technical refinements in the Washio tempororetroauricular flap in reconstruction of the nasal wing. Scand J Plast Reconstr Surg Hand Surg; 2005;39(5):295-8
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  • [Title] Technical refinements in the Washio tempororetroauricular flap in reconstruction of the nasal wing.
  • Retroauricular tissue for reconstruction of external nasal defects was described by Washio.
  • We describe our recent experiences in elderly patients, in whom the risk of reconstruction after excision of a malignant growth is high.
  • We present seven reconstructions, six after excision of malignant disease, together with our ideas about how to maximise its possibilities.

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  • (PMID = 16320406.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Lü BJ, Zhu J, Gao L, Xie L, Xu JY, Lai MD: [Diagnostic accuracy and pitfalls in fine needle aspiration cytology of salivary glands: a study of 113 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):706-10
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  • Cytologically, the distinction between cellular pleomorphic adenoma, adenoid cystic carcinoma and basal cell adenoma could be difficult due to their overlapping morphologic features.
  • The cytologic patterns of primary lymphoepithelial carcinoma of the parotid were indistinguishable from those of metastatic nasopharyngeal undifferentiated carcinoma.
  • The three inaccurately diagnosed cases of FNAC are, as follows: reactive lymphoid hyperplasia of lymph node mistaken as non-Hodgkin lymphoma, mucoepidermoid carcinoma diagnosed as "scanty atypical cells present" and primary lymphoepithelial carcinoma mistaken as benign lymphoepithelial lesion.
  • On the other hand, due to the pitfalls in cytologic diagnosis of certain salivary gland tumors, tissue biopsy for histologic examination may be necessary.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Carcinoma, Adenoid Cystic / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Parotid Neoplasms / pathology. Retrospective Studies. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16536312.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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51. Arco G, Horch RE, Arkudas A, Dragu A, Bach AD, Kneser U: Double pedicled perforator flap to close flank defects: an alternative for closure of a large lumbar defect after basalioma excision--a case report and review of the literature. Ann Plast Surg; 2009 Oct;63(4):422-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Surgical Flaps / blood supply

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  • (PMID = 19745707.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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52. Ono I, Yamashita T, Takada T, Tominaga A, Hirosaki K, Jimbow K: Reconstruction method with a newly-designed bilobed flap after excision of tumours of the skin. Scand J Plast Reconstr Surg Hand Surg; 2006;40(1):32-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reconstruction method with a newly-designed bilobed flap after excision of tumours of the skin.
  • We have devised a bilobed skin flap for reconstruction after excision of small skin tumours.
  • The sutured part serves as a zig-zag that leads to only slight postoperative contracture of the scar.
  • The rotation centre of the flap is nearer to the affected area than other conventional bilobed flaps, resulting in less dog-ear deformity and distortion of tissue.

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  • (PMID = 16428211.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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53. Gokrem S, Tuncali D, Akbuga U, Terzioglu A, Aslan G: Reconstruction of small to medium defects in the soft tissues of the nose with nasalis musculocutaneous V-Y advancement flaps. Scand J Plast Reconstr Surg Hand Surg; 2006;40(3):140-7
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

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  • [Title] Reconstruction of small to medium defects in the soft tissues of the nose with nasalis musculocutaneous V-Y advancement flaps.
  • Defects in the soft tissues of the nose are usually reconstructed with skin grafts or frontal flaps.
  • However, skin grafts may cause scar tissue and changes in colour.
  • Frontal flaps, however, may be thicker than normal skin and may give unsatisfactory results.
  • Nasalis musculocutaneous V-Y advancement flaps avoid these disadvantages.
  • We suggest an algorithmic approach for the use of these flaps in the reconstruction of small to medium defects in the soft tissues of various regions of the nose.
  • The pedicles of these flaps are the dorsal and lateral nasal arteries.
  • This approach provides a simple, safe, and reliable reconstruction for small and medium defects in the soft tissues of the nose.

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  • (PMID = 16687333.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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54. Posch NA, Mureau MA, Flood SJ, Hofer SO: The combined free partial vastus lateralis with anterolateral thigh perforator flap reconstruction of extensive composite defects. Br J Plast Surg; 2005 Dec;58(8):1095-103
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Child. Female. Humans. Lumbosacral Region / surgery. Male. Middle Aged. Neoplasm Recurrence, Local. Patient Satisfaction. Postoperative Complications / etiology. Reconstructive Surgical Procedures / methods. Spinal Dysraphism / surgery. Treatment Outcome

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  • (PMID = 16043151.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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55. Schellekens PP, Hage JJ, Paes EC, Kon M: Clinical application and outcome of the internal mammary artery perforator (IMAP) free flap for soft tissue reconstructions of the upper head and neck region in three patients. Microsurgery; 2010 Nov;30(8):627-31
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Aged. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Cheek. Ear Canal / pathology. Facial Neoplasms / surgery. Female. Humans. Male. Middle Aged. Soft Tissue Neoplasms / surgery

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  • (PMID = 20973094.001).
  • [ISSN] 1098-2752
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Lee PL, Lourduraj LT, Palko MJ 3rd, Jukic DM, English JC 3rd: Hereditary basaloid follicular hamartoma syndrome. Cutis; 2006 Jul;78(1):42-6
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Facial Dermatoses / diagnosis. Hamartoma / diagnosis. Hand Dermatoses / diagnosis. Skin Diseases / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Cutis. 2007 Feb;79(2):154; author reply 155-6 [17388219.001]
  • (PMID = 16903320.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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57. Gaál M, Gyulai R, Baltás E, Kui R, Oláh J, Kemény L: [Photodynamic therapy in dermatooncology]. Orv Hetil; 2007 Nov 25;148(47):2227-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Because of their frequent localization on the face and hand, aesthetic aspects of the therapeutic procedures should also be considered.
  • Surgical excision still remains the first choice, but recently several new alternative therapies have emerged, especially for the treatment of superficial skin cancer.
  • Efficacy of the photodynamic therapy has been proven in solar keratosis, superficial basal cell carcinoma and morbus Bowen, with significantly better cosmetic outcome than that of the conventional therapeutic methods.
  • The present article summarizes the authors' experiences with photodynamic treatment (212 non-melanoma skin cancer patients were treated with PDT between December 2003 and January 2006), at the Department of Dermatology and Allergology, University of Szeged, Hungary, and reviews the literature of photodynamic therapy in dermatooncology.
  • [MeSH-minor] Carcinoma, Squamous Cell / drug therapy. Evidence-Based Medicine. Humans. Hungary. Photosensitizing Agents / therapeutic use. Retrospective Studies. Treatment Outcome

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  • (PMID = 18003581.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Photosensitizing Agents
  • [Number-of-references] 38
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58. Sebastian G: [Operative appraoches at problem sites]. Hautarzt; 2007 Aug;58(8):672-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Facial Neoplasms / surgery. Melanoma / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery
  • [MeSH-minor] Anus Neoplasms / pathology. Anus Neoplasms / surgery. Esthetics. Female. Hand / surgery. Humans. Lip Neoplasms / pathology. Lip Neoplasms / surgery. Male. Penile Neoplasms / pathology. Penile Neoplasms / surgery. Postoperative Complications / surgery. Reoperation. Surgical Flaps. Suture Techniques

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  • (PMID = 17569020.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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59. De D, Narang T, Dogra S, Kanwar AJ: Asymptomatic palmar pits: clinical evaluation of six cases and review of the literature. J Cutan Med Surg; 2008 Jul-Aug;12(4):198-202

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSIONS: Palmar pits may have sinister implications in conditions such as nevoid basal cell carcinoma syndrome or Cowden syndrome.
  • [MeSH-major] Hand Dermatoses / diagnosis

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  • (PMID = 18627702.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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60. Mutaf M, Sunay M, Bulut O: The "reading man" procedure: a new technique for the closure of circular skin defects. Ann Plast Surg; 2008 Apr;60(4):420-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The procedure is named as "the reading man" because its surgical design resembles the silhouette of a man who is reading a book held in his hand.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery

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  • (PMID = 18362572.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Yoshino M, Ishiwata T, Watanabe M, Matsunobu T, Komine O, Ono Y, Yamamoto T, Fujii T, Matsumoto K, Tokunaga A, Naito Z: Expression and roles of keratinocyte growth factor and its receptor in esophageal cancer cells. Int J Oncol; 2007 Oct;31(4):721-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and roles of keratinocyte growth factor and its receptor in esophageal cancer cells.
  • In this study, we examined the roles of KGFR and KGF in human esophageal cancer (EC).
  • In noncancerous esophageal tissues, KGFR was localized in epithelial cells from the basal region of the epithelium to the lower one-third of the epithelium, and KGF was weakly localized in the basal to parabasal epithelial cells.
  • On the other hand, Ki-67 was localized in the parabasal cells.
  • In EC tissues, KGFR and KGF were expressed in cancer cells in 22 and 37 of 54 patients, respectively.
  • The coexpression of KGFR and KGF in cancer cells was detected in 14 of 54 (26%) patients.
  • Clinicopathologically, KGFR expression correlated with the well-differentiated cell type of EC (p<0.001), and KGF expression correlated with lymphatic invasion and lymph node metastasis (p=0.004 and 0.021, respectively).
  • The coexpression of KGFR and KGF in cancer cells correlated with the well-differentiated cell type of EC (p=0.001).
  • In human EC cell lines (TE-1, TE-8 and TE-11), KGFR mRNA was expressed but no KGF mRNA was detected.
  • KGFR was detected in the cancer cell lines by Western blot analysis.
  • Recombinant human KGF significantly stimulated the growth of TE-8 and -11 cells, derived from moderately differentiated SCC, but had no effect on TE-1 cell growth.
  • These results suggest that KGFR expression correlates with the differentiation of a normal esophageal epithelium and the well-differentiated cell type of EC.
  • On the other hand, KGF may induce the growth of some EC cells in a paracrine manner and closely correlates with lymphatic invasion and lymph node metastasis.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adult. Aged. Aged, 80 and over. Blotting, Western. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Cell Differentiation. Epithelial Cells. Female. Humans. Ki-67 Antigen / metabolism. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 17786302.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 126469-10-1 / Fibroblast Growth Factor 7; EC 2.7.1.- / keratinocyte growth factor receptor; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 2
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62. Brown VL, Atkins CL, Ghali L, Cerio R, Harwood CA, Proby CM: Safety and efficacy of 5% imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial. Arch Dermatol; 2005 Aug;141(8):985-93
Hazardous Substances Data Bank. Imiquimod .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS: Twenty-one high-risk patients with skin cancer with comparable areas of clinically atypical skin on dorsal hands or forearms.
  • INTERVENTIONS: Imiquimod or placebo (randomly assigned) applied 3 times a week for 16 weeks to 1 dorsal hand or forearm, with 8 months of follow-up.
  • [MeSH-minor] Acitretin / therapeutic use. Administration, Topical. Adult. Aged. Carcinoma, Basal Cell / drug therapy. Carcinoma, Basal Cell / prevention & control. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / prevention & control. Double-Blind Method. Female. Humans. Immunosuppression. Keratolytic Agents / therapeutic use. Male. Middle Aged. Ointments. Risk Factors

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  • (PMID = 16103328.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Keratolytic Agents; 0 / Ointments; 99011-02-6 / imiquimod; LCH760E9T7 / Acitretin
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63. Martin MC, Machado GR, Wong WW, Yeung LC, Jean RD: Transverse ulnar forearm flap. J Craniofac Surg; 2010 Nov;21(6):1741-4
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: All TUFF and radial fasciocutaneous flaps survived completely without partial or total losses or ischemic hand complications.
  • [MeSH-minor] Achilles Tendon / injuries. Achilles Tendon / surgery. Adolescent. Adult. Aged. Carcinoma, Basal Cell / surgery. Fascia / transplantation. Female. Foot Ulcer / surgery. Forearm / surgery. Graft Survival. Humans. Male. Nose Diseases / surgery. Oral Fistula / surgery. Orbit Evisceration. Orbital Neoplasms / surgery. Range of Motion, Articular / physiology. Respiratory Tract Fistula / surgery. Retrospective Studies. Rupture. Surgical Wound Dehiscence / surgery. Surgical Wound Infection / surgery. Tissue and Organ Harvesting / methods. Treatment Outcome. Ulna / surgery. Wrist Joint / physiology. Young Adult

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  • (PMID = 21119412.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Shen SC, Lee WR, Fang YP, Hu CH, Fang JY: In vitro percutaneous absorption and in vivo protoporphyrin IX accumulation in skin and tumors after topical 5-aminolevulinic acid application with enhancement using an erbium:YAG laser. J Pharm Sci; 2006 Apr;95(4):929-38
Hazardous Substances Data Bank. YTTRIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The efficacy of the improved drug delivery was determined as a function of various laser fluences and cancer models.
  • On the other hand, the fluorescence intensity of the control group was much lower than that of laser-treated group.
  • [MeSH-major] Aminolevulinic Acid / therapeutic use. Carcinoma, Basal Cell / drug therapy. Lasers. Photochemotherapy. Photosensitizing Agents / therapeutic use. Protoporphyrins / metabolism. Protoporphyrins / therapeutic use. Skin Absorption. Skin Neoplasms / drug therapy
  • [MeSH-minor] Administration, Cutaneous. Aluminum. Animals. Cell Line, Tumor. Erbium. Female. In Vitro Techniques. Mice. Mice, Inbred BALB C. Neoplasm Transplantation. Water Loss, Insensible. Yttrium

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  • (PMID = 16493590.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Protoporphyrins; 0 / yttrium-aluminum-garnet; 553-12-8 / protoporphyrin IX; 58784XQC3Y / Yttrium; 77B218D3YE / Erbium; 88755TAZ87 / Aminolevulinic Acid; CPD4NFA903 / Aluminum
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65. Takase K, Ohyagi Y, Furuya H, Nagashima K, Taniwaki T, Kira J: [A case of progressive multifocal leukoencephalopathy presenting white matter MRI lesions extending over the cerebral cortex and a marked decrease in cerebral blood flow on SPECT, and associated with HTLV-I infection]. Rinsho Shinkeigaku; 2005 Jun;45(6):426-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • She had a malignant lymphoma in the left neck and basal cell carcinoma in the right inguinal region.
  • A biopsy of the left parotid gland revealed a diffuse pleomorphic type large B cell lymphoma.
  • Although anti-HTLV-I antibody was positive in the serum and cerebrospinal fluid (CSF), no adult T-cell leukemia (ATL) cells were found in the blood or CSF.
  • Neurological examinations revealed severe motor aphasia, mild sensory aphasia/cognitive impairment, right hemiplegia, mild right hemihypesthesia, limb-kinetic apraxia in the left hand, idiomotor apraxia, agraphia, perseveration, marked spasticity and brisk tendon reflex in four extremities, and positive bilateral pathological reflexes.
  • CSF examination revealed that the cell count (1/microl), protein level (24 mg/dl), and IgG index (0.4) were all normal.
  • [MeSH-minor] Aphasia, Broca / etiology. Cerebrovascular Circulation. Female. Humans. Lymphoma, B-Cell / complications. Magnetic Resonance Imaging. Middle Aged. Regional Blood Flow. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 16022467.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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66. Mahajan VK, Sharma NL, Shanker V, Gupta P, Mardi K: Cutaneous sporotrichosis: unusual clinical presentations. Indian J Dermatol Venereol Leprol; 2010 May-Jun;76(3):276-80
Hazardous Substances Data Bank. POTASSIUM IODIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Case 1, a 52-year-old man, developed sporotrichosis over pre-existing facial nodulo-ulcerative basal cell carcinoma of seven-year duration, due to its contamination perhaps from topical herbal pastes and lymphocutaneous sporotrichosis over right hand/forearm from facial lesion/herbal paste.

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  • (PMID = 20445301.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 1C4QK22F9J / Potassium Iodide
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67. Euvrard S: [Skin cancers after organ transplants]. Presse Med; 2008 Oct;37(10):1475-9
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Squamous cell carcinoma and basal cell carcinoma are the most common cancers after transplants, affecting more than half of all patients in the long term.
  • In the 5 years after a first squamous cell carcinoma, 90 to 100% of transplant patients subsequently develop multiple skin carcinomas of various types and at least 20% develop noncutaneous cancers.
  • On the other hand, the benefit of prescribing them later after the transplant remains to be shown, because of the frequency of intolerance phenomena.
  • Several prospective French multicenter studies are currently assessing the effect of replacing anticalcineurins by sirolimus or everolimus for secondary prevention of skin cancers in renal or cardiac transplant patients who have already developed skin cancer.

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  • (PMID = 18775633.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 12
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68. Schmitt J, Diepgen T, Bauer A: Occupational exposure to non-artificial UV-light and non-melanocytic skin cancer - a systematic review concerning a new occupational disease. J Dtsch Dermatol Ges; 2010 Apr;8(4):250-63, 250-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occupational exposure to non-artificial UV-light and non-melanocytic skin cancer - a systematic review concerning a new occupational disease.
  • BACKGROUND: Although UV exposure is the most important risk factor for cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), a systematic review analyzing the risk of occupational UV exposure is missing.
  • METHODS: Based on a systematic literature search in PubMed (until 05/2009) supplemented by hand search, the association between occupational UV exposure and SCC and BCC was analyzed.
  • The association between occupational UV exposure and cancer risk is presented as odds ratios (OR).

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  • (PMID = 19832928.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 40
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69. Rallis E, Nasiopoulou A, Arvanitis A: Interdigital basal cell carcinoma of the hand: a rare site. Indian J Dermatol Venereol Leprol; 2010 Sep-Oct;76(5):593
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interdigital basal cell carcinoma of the hand: a rare site.
  • [MeSH-major] Hand. Neoplasms, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 20827022.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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70. van Steensel MA, Frank J: Monoclonal origin of anatomically distinct basal cell carcinomas: is there really hard evidence at hand? J Invest Dermatol; 2006 Dec;126(12):2727-9; author reply 2729-30
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Monoclonal origin of anatomically distinct basal cell carcinomas: is there really hard evidence at hand?
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Chromosomes, Human, Pair 9. Loss of Heterozygosity. Neoplasms, Second Primary / genetics. Skin Neoplasms / genetics. X Chromosome Inactivation

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  • [CommentOn] J Invest Dermatol. 2006 Mar;126(3):676-9 [16410785.001]
  • (PMID = 16874313.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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71. Tehrani H, Iqbal A: Basal cell carcinoma of the thumb. J Hand Surg Eur Vol; 2009 Oct;34(5):699-700
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma of the thumb.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Nail Diseases / pathology. Skin Neoplasms / pathology. Thumb

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  • (PMID = 19959459.001).
  • [ISSN] 2043-6289
  • [Journal-full-title] The Journal of hand surgery, European volume
  • [ISO-abbreviation] J Hand Surg Eur Vol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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72. Abeldaño AM, Tiscornia J, Cendeño LP, Brea P, Chouela EN: Basal cell carcinoma in palm and sole. Skinmed; 2006 Jan-Feb;5(1):40-2
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma in palm and sole.
  • [MeSH-major] Carcinoma, Basal Cell. Skin Neoplasms
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Foot. Hand. Humans. Middle Aged

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  • (PMID = 16522984.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Lindelöf B: [Basal cell cancer should primarily be treated surgically. There are a lot of alternative therapeutic methods but few comparative studies]. Lakartidningen; 2005 May 23-29;102(21):1650-1
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Basal cell cancer should primarily be treated surgically. There are a lot of alternative therapeutic methods but few comparative studies].
  • [Transliterated title] Basalcellscancer bör i första hand behandlas kirurgiskt. Flora av alternativa behandlingsmetoder men få jämförande studier.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Skin Neoplasms / surgery

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  • (PMID = 15962888.001).
  • [ISSN] 0023-7205
  • [Journal-full-title] Läkartidningen
  • [ISO-abbreviation] Lakartidningen
  • [Language] swe
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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74. Lateo S, Charlton FG, Ormond P: A palmar injury that failed to heal. Diagnosis: basal cell carcinoma of the palm. Clin Exp Dermatol; 2006 Sep;31(5):731-2
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A palmar injury that failed to heal. Diagnosis: basal cell carcinoma of the palm.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Hand. Hand Injuries / complications. Skin Neoplasms / pathology

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  • (PMID = 16901328.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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75. Cabo H, Kolm I, Puig S, Malvehy J: Palmar basal cell carcinoma in a patient with Gorlin-Goltz syndrome. Arch Dermatol; 2007 Jun;143(6):813-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Palmar basal cell carcinoma in a patient with Gorlin-Goltz syndrome.
  • [MeSH-major] Basal Cell Nevus Syndrome. Carcinoma, Basal Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hand / pathology. Humans

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  • (PMID = 17576964.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R0-1 CA 83115
  • [Publication-type] Case Reports; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Nakamura M, Tokura Y: A novel missense mutation in the PTCH1 gene in a premature case of nevoid basal cell carcinoma syndrome. Eur J Dermatol; 2009 May-Jun;19(3):262-3
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel missense mutation in the PTCH1 gene in a premature case of nevoid basal cell carcinoma syndrome.
  • [MeSH-major] Basal Cell Nevus Syndrome / genetics. Mutation, Missense. Receptors, Cell Surface / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Female. Foot / pathology. Genes, Neoplasm / genetics. Hand / pathology. Humans. Skin / pathology. Young Adult

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  • (PMID = 19213655.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Cell Surface; 0 / patched receptors
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77. Nguyen TH: Mohs bashing out of hand. Plast Reconstr Surg; 2005 Jan;115(1):361-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs bashing out of hand.
  • [MeSH-minor] Ambulatory Surgical Procedures / adverse effects. Ambulatory Surgical Procedures / education. Ambulatory Surgical Procedures / psychology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Dermatology / education. Head and Neck Neoplasms / surgery. Humans. Outpatients / psychology. Patient Satisfaction. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Skin Neoplasms / surgery

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  • [CommentOn] Plast Reconstr Surg. 2004 Feb;113(2):774-5 [14758268.001]
  • (PMID = 15622305.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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