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Items 1 to 32 of about 32
1. Jankovic I, Kovacevic P, Visnjic M, Jankovic D, Binic I, Jankovic A: Does incomplete excision of basal cell carcinoma of the eyelid mean tumor recurrence? An Bras Dermatol; 2010 Nov-Dec;85(6):872-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does incomplete excision of basal cell carcinoma of the eyelid mean tumor recurrence?
  • INTRODUCTION: Basal cell carcinoma is the most common tumor of the eyelid.
  • OBJECTIVE: To define the relationship between margin clearance at excision and the recurrence rate of basal cell carcinoma of the eyelid.
  • METHODS: This prospective study was conducted with 111 patients submitted to surgery for basal cell carcinoma of the eyelid between 2001 and 2003 and followed up for a period of five years.
  • CONCLUSION: A risk of recurrence in incompletely excised basal cell carcinomas of the eyelid was only confirmed in younger patients, females and for tumors of the medial canthus.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Mohs Surgery / methods. Neoplasm Recurrence, Local. Skin Neoplasms / surgery

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  • [CommentIn] An Bras Dermatol. 2011 Mar-Apr;86(2):401; author reply 401-3 [21603839.001]
  • (PMID = 21308312.001).
  • [ISSN] 1806-4841
  • [Journal-full-title] Anais brasileiros de dermatologia
  • [ISO-abbreviation] An Bras Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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2. Leppälä J, Kaarniranta K, Uusitalo H, Kontkanen M: Imiquimod in the treatment of eyelid basal cell carcinoma. Acta Ophthalmol Scand; 2007 Aug;85(5):566-8
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  • [Title] Imiquimod in the treatment of eyelid basal cell carcinoma.
  • PURPOSE: To assess the efficacy and safety of topical imiquimod 5% cream in the treatment of eyelid basal cell carcinoma.
  • METHODS: Four patients with eyelid basal cell carcinoma were treated with imiquimod once daily, 5 days per week, for 6 weeks.
  • RESULTS: In the 12-week follow-up after imiquimod treatment, histopathological tissue sample analysis showed no signs of basal cell carcinoma in any of the patients.
  • CONCLUSIONS: The results indicate that 5% imiquimod cream with topical administration may represent a new therapy option for eyelid basal cell carcinoma.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Basal Cell / drug therapy. Eyelid Neoplasms / drug therapy

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  • (PMID = 17376190.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Ointments; 99011-02-6 / imiquimod
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3. Lin LK, Lee H, Chang E: Pigmented basal cell carcinoma of the eyelid in Hispanics. Clin Ophthalmol; 2008 Sep;2(3):641-3
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  • [Title] Pigmented basal cell carcinoma of the eyelid in Hispanics.
  • BACKGROUND: Pigmented basal cell carcinoma (PBCC) of the eyelid has not been well cited in the literature, and is often overlooked in the differential diagnosis of pigmented eyelid lesions.
  • We aim to describe PBCC of the eyelid in Hispanic patients.
  • METHODS: Retrospective review of patients with eyelid skin cancer who presented to the Department of Dermatology at the Keck School of Medicine of the University of Southern California and the Doheny Eye Institute from January 2002 to November 2005.
  • RESULTS: Sixty-nine of the 79 patients with eyelid skin cancer had basal cell carcinoma.
  • CONCLUSIONS: Although eyelid PBCC is regarded as a rare condition, it may occur more commonly in the Hispanic population and should be remembered in the differential diagnosis of pigmented eyelid lesions.

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  • (PMID = 19668766.001).
  • [ISSN] 1177-5467
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2694027
  • [Keywords] NOTNLM ; eyelid / lesions / pigmented basal cell carcinoma / skin cancer
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4. Rajan N, Varma D, Chapman F, Langtry JA: Painful eye caused by basal cell carcinoma of the eyelid: tumour enlargement resulting in trichiasis. Acta Derm Venereol; 2008;88(1):66
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  • [Title] Painful eye caused by basal cell carcinoma of the eyelid: tumour enlargement resulting in trichiasis.
  • [MeSH-major] Carcinoma, Basal Cell / complications. Eyelid Neoplasms / complications. Hair Diseases / etiology. Pain / etiology. Skin Neoplasms / complications

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  • (PMID = 18176757.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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5. Hamada S, Kersey T, Thaller VT: Eyelid basal cell carcinoma: non-Mohs excision, repair, and outcome. Br J Ophthalmol; 2005 Aug;89(8):992-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid basal cell carcinoma: non-Mohs excision, repair, and outcome.
  • AIM: To analyse the outcome of basal cell carcinoma (BCC) excision in a subregional (non-Mohs) oculoplastic service.
  • METHODS: A single surgeon retrospective series, medical record review of 223 consecutive cases with histologically confirmed eyelid BCC (between 1987 and 2004).
  • [MeSH-major] Blepharoplasty / methods. Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery

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  • (PMID = 16024851.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1772767
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6. Matysik-Woźniak A, Gerkowicz M, Pawłowska-Wakowicz B: Basal cell carcinoma in an eyelid of a farmer with Sturge-Weber syndrome. Ann Agric Environ Med; 2007;14(2):325-7
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  • [Title] Basal cell carcinoma in an eyelid of a farmer with Sturge-Weber syndrome.
  • The paper presents the coexistence of a nevus flammeus and basal cell carcinoma affecting the left upper lid of 61-year-old farmer with Sturge-Weber syndrome.
  • The occurrence of basal cell carcinoma in nevus flammeus is extremely rare.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Eyelid Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Sturge-Weber Syndrome / complications. Sturge-Weber Syndrome / pathology. Sunlight / adverse effects. Treatment Outcome

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  • (PMID = 18247471.001).
  • [ISSN] 1232-1966
  • [Journal-full-title] Annals of agricultural and environmental medicine : AAEM
  • [ISO-abbreviation] Ann Agric Environ Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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7. Paavilainen V, Tuominen J, Pukkala E, Saari KM: Basal cell carcinoma of the eyelid in Finland during 1953-97. Acta Ophthalmol Scand; 2005 Apr;83(2):215-20
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  • [Title] Basal cell carcinoma of the eyelid in Finland during 1953-97.
  • PURPOSE: To study the incidence of basal cell carcinoma (BCC) of the eyelid in Finland.
  • METHODS: We studied 6241 cases of BCC of the eyelid reported to the nationwide Finnish Cancer Registry during 1953-97.
  • RESULTS: The incidence rates of BCC of the eyelid varied between 0.7 and 3.0 per 100 000 person-years in men and between 0.5 and 2.8 per 100 000 person-years in women during the study period.
  • The age-adjusted incidence rates of BCC of the eyelid increased during 1953-87 (p < 0.0001).
  • The incidence of BCC of the eyelid rose significantly with age.
  • There were no significant differences in standardized incidence ratios (SIRs) for BCC of the eyelid between different social class and occupation categories.
  • CONCLUSION: Age-adjusted incidence rates showed that BCC of the eyelid was more than twice as frequent during 1978-97 than before 1968.
  • Ageing may partly explain the increased incidence of BCC of the eyelid, whereas there were no differences in the SIRs for BCC of the eyelid between different social class and occupation categories in Finland.
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Eyelid Neoplasms / epidemiology. Skin Neoplasms / epidemiology

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  • (PMID = 15799736.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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8. Paavilainen V, Tuominen J, Aho VV, Saari KM: Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland. Eur J Ophthalmol; 2007 Jul-Aug;17:494-500

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland.
  • : . PURPOSE: Basal cell carcinoma (BCC) is the most common skin cancer of the eyelid, showing an increasing incidence in the white population.
  • The authors studied the clinical characteristics and the treatment results of BCC of the eyelid in southwestern Finland during 1977-1997.
  • RESULTS: The 191 patients had altogether 194 BCC tumors of the eyelid with the mean diameter of the tumor being smaller than 10 mm in 77.3% of cases.
  • Of the 194 BCC tumors of the eyelid 16.0% showed recurrence, and the recurrence rate of all surgically treated tumors was 13.7%.
  • In this study 61 patients (31.9%) developed other malignancies than the BCC of the eyelid including 28 patients (14.7 %) with carcinoma in other locations than skin.
  • CONCLUSIONS: Incompletely removed BCCs of the eyelid showed only 18.9% recurrence rate during the follow-up time.
  • On the other hand, BCCs of the eyelid should not be underestimated because of the rather high total recurrence rate.
  • The frequency of 31.9% of other malignancies than BCC of the eyelid is remarkably high and requires special attention from the ophthalmologist taking care of the patient with BCC of the eyelid.

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  • (PMID = 28221540.001).
  • [ISSN] 1724-6016
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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9. Belliveau MJ, Coupal DJ, Brownstein S, Jordan DR, Prokopetz R: Infundibulocystic basal cell carcinoma of the eyelid in basal cell nevus syndrome. Ophthal Plast Reconstr Surg; 2010 May-Jun;26(3):147-52
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  • [Title] Infundibulocystic basal cell carcinoma of the eyelid in basal cell nevus syndrome.
  • PURPOSE: To describe the histopathologic findings in a series of eyelid basal cell carcinomas removed from patients with basal cell nevus syndrome.
  • METHODS: Retrospective case series of 5 patients with basal cell nevus syndrome identified from our oculoplastics service.
  • The systemic and ophthalmic features were reviewed, and a retrospective histopathologic analysis of all available previously excised eyelid lesions was performed.
  • The pertinent published literature on basal cell nevus syndrome and eyelid basal cell carcinoma was reviewed.
  • RESULTS: A total of 26 eyelid lesions were examined histopathologically.
  • Twenty-three of these lesions were basal cell carcinomas.
  • The infundibulocystic variant of basal cell carcinoma was identified most commonly (57%).
  • CONCLUSIONS: Eyelid basal cell carcinomas in patients with basal cell nevus syndrome were commonly of the infundibulocystic variety in our series.
  • Infundibulocystic basal cell carcinomas, which can be clinically indistinguishable from the more common forms, are thought to be less aggressive than other types of basal cell carcinoma and are a reassuring histopathologic diagnosis.
  • It is important for the ophthalmologist and pathologist to be aware of infundibulocystic basal cell carcinomas, as they are more common in patients with basal cell nevus syndrome and may be a clue to the diagnosis of this autosomal dominant cancer-predisposition syndrome or other associated syndromes.
  • To our knowledge, this variant of basal cell carcinoma has not been previously discussed in the ophthalmic literature.
  • [MeSH-major] Basal Cell Nevus Syndrome / pathology. Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology


10. Puccioni M, Santoro N, Giansanti F, Ucci F, Rossi R, Lotti T, Menchini U: Photodynamic therapy using methyl aminolevulinate acid in eyelid basal cell carcinoma: a 5-year follow-up study. Ophthal Plast Reconstr Surg; 2009 Mar-Apr;25(2):115-8

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  • [Title] Photodynamic therapy using methyl aminolevulinate acid in eyelid basal cell carcinoma: a 5-year follow-up study.
  • PURPOSE: To evaluate retrospectively the long-term results of methyl aminolevulinate photodynamic therapy for the treatment of eyelid basal cell carcinoma.
  • METHODS: Sixteen consecutive patients with eyelid basal cell carcinoma were treated with methyl aminolevulinate photodynamic therapy between January 2002 and April 2003.
  • CONCLUSIONS: The absence of complications, good tolerance, and a notable success rate make this nonsurgical procedure promising for the treatment of basal cell carcinoma of the eyelid in selected patients.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Carcinoma, Basal Cell / drug therapy. Eyelid Neoplasms / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use

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  • (PMID = 19300153.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / methyl 5-aminolevulinate; 88755TAZ87 / Aminolevulinic Acid
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11. Russell DJ, Dutton JJ, Fowler AM: Darier disease mimicking Basal cell carcinoma of the eyelid. Ophthal Plast Reconstr Surg; 2009 Mar-Apr;25(2):144-6
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  • [Title] Darier disease mimicking Basal cell carcinoma of the eyelid.
  • Darier disease is a rare autosomal dominant skin disorder that infrequently has ocular manifestations.
  • The authors describe 2 cases of patients with known Darier disease presenting with eyelid lesions resembling basal cell carcinomas.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Darier Disease / pathology. Eyelid Diseases / pathology. Eyelid Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 19300164.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Kotimäki J: Photodynamic therapy of eyelid basal cell carcinoma. J Eur Acad Dermatol Venereol; 2009 Sep;23(9):1083-7
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  • [Title] Photodynamic therapy of eyelid basal cell carcinoma.
  • OBJECTIVE: A series of six patient cases was used to evaluate the efficacy of PDT in the treatment of lower eyelid basal cell carcinoma (BCC).
  • RESULTS: Six patients with lower eyelid BCC were treated with two treatment sessions of PDT within a week.
  • CONCLUSION: PDT, although experimental in the eyelid area because of the small amount of data and the lack of a long-term follow-up, may be considered a promising comprehensive alternative when treating BCC in the eyelid area.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Carcinoma, Basal Cell / drug therapy. Eyelids. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 19470065.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / methyl 5-aminolevulinate; 88755TAZ87 / Aminolevulinic Acid
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13. Paavilainen V, Aaltonen M, Tuominen J, Saari KM: Histological characteristics of basal cell carcinoma of the eyelid. Ophthalmic Res; 2007;39(1):45-8

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  • [Title] Histological characteristics of basal cell carcinoma of the eyelid.
  • PURPOSE: To evaluate the histological subtypes of basal cell carcinoma (BCC) of the eyelid and to determine their effect on the size, depth of invasion and need of retreatment of a nonselected patient material seen in south-western Finland.
  • METHODS: We studied the case records and the histological characteristics of BCC of the eyelid treated at the Turku University Eye Clinic during the years 1988 through 1997.
  • The material consisted 103 patients (103 BCC tumors of the eyelid).
  • The most frequent histological subtype was nodular (84.5%) followed by sclerosing (5.8%), micronodular (4.9%), keratotic (2.9%) and superficial (1.9%) types of BCC of the eyelid.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 17164577.001).
  • [ISSN] 0030-3747
  • [Journal-full-title] Ophthalmic research
  • [ISO-abbreviation] Ophthalmic Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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14. Auw-Haedrich C, Frick S, Boehringer D, Mittelviefhaus H: Histologic safety margin in basal cell carcinoma of the eyelid: correlation with recurrence rate. Ophthalmology; 2009 Apr;116(4):802-6
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  • [Title] Histologic safety margin in basal cell carcinoma of the eyelid: correlation with recurrence rate.
  • OBJECTIVE: To examine the correlation between the minimum histologic safety margin (HSM) and recurrence rate of periorbital basal cell carcinomas (BCC).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Ophthalmology. 2010 Feb;117(2):403-4; author reply 404 [20141864.001]
  • [CommentIn] Ophthalmology. 2009 Nov;116(11):2266-7; author reply 2267 [19883865.001]
  • (PMID = 19232734.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Paavilainen V, Tuominen J, Aho VV, Saari KM: Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland. Eur J Ophthalmol; 2007 Jul-Aug;17(4):494-500

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland.
  • PURPOSE: Basal cell carcinoma (BCC) is the most common skin cancer of the eyelid, showing an increasing incidence in the white population.
  • The authors studied the clinical characteristics and the treatment results of BCC of the eyelid in southwestern Finland during 1977-1997.
  • RESULTS: The 191 patients had altogether 194 BCC tumors of the eyelid with the mean diameter of the tumor being smaller than 10 mm in 77.3% of cases.
  • Of the 194 BCC tumors of the eyelid 16.0% showed recurrence, and the recurrence rate of all surgically treated tumors was 13.7%.
  • In this study 61 patients (31.9%) developed other malignancies than the BCC of the eyelid including 28 patients (14.7 %) with carcinoma in other locations than skin.
  • CONCLUSIONS: Incompletely removed BCCs of the eyelid showed only 18.9% recurrence rate during the follow-up time.
  • On the other hand, BCCs of the eyelid should not be underestimated because of the rather high total recurrence rate.
  • The frequency of 31.9% of other malignancies than BCC of the eyelid is remarkably high and requires special attention from the ophthalmologist taking care of the patient with BCC of the eyelid.
  • [MeSH-major] Carcinoma, Basal Cell / therapy. Eyelid Neoplasms / therapy. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 17671921.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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16. Chen Z, Yang J, Huang Q: Correlation and expression of COX-2 and P53 protein in basal cell carcinoma of eyelid. J Huazhong Univ Sci Technolog Med Sci; 2009 Jun;29(3):383-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation and expression of COX-2 and P53 protein in basal cell carcinoma of eyelid.
  • The correlation between the expression of COX-2 and p53 protein in basal cell carcinoma (BCC) of eyelid and apoptosis was investigated.
  • It was found that COX-2 and p53 proteins were highly expressed in BCC of eyelid, and weakly expressed in paracancerous tissues.
  • Image analysis revealed that the expression of COX-2 and p53 proteins in BCC of eyelid was significantly higher than that in paracancerous tissues (P<0.01).
  • [MeSH-major] Apoptosis. Carcinoma, Basal Cell / metabolism. Cyclooxygenase 2 / metabolism. Eyelid Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19513627.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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17. Schlötzer-Schrehardt U, Stojkovic M, Hofmann-Rummelt C, Cursiefen C, Kruse FE, Holbach LM: The Pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradation. Ophthalmology; 2005 Apr;112(4):694-704
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradation.
  • OBJECTIVE: To investigate histopathologic alterations of eyelid biopsy specimens from patients with floppy eyelid syndrome (FES) with special regard to elastic fiber content and ultrastructure as well as to the expression of elastin-degrading enzymes to elucidate the pathogenesis of this disorder.
  • PARTICIPANTS AND CONTROLS: Eleven consecutive patients with FES and 10 age-matched control patients with basal cell carcinoma of the eyelid.
  • METHODS: Horizontal pentagonal eyelid resections of 16 upper lids were performed in 11 patients with FES.
  • Full-thickness eyelid biopsy specimens from study and control patients were examined by light and transmission electron microscopy, semiquantitative morphometry, and immunohistochemistry using antibodies against matrix metalloproteinase (MMP)-2, MMP-7, MMP-9, and MMP-12 and neutrophil elastase.
  • RESULTS: All patients treated with surgical horizontal eyelid shortening were asymptomatic at follow-up.
  • Histopathologic analysis of the surgical specimens showed, apart from unspecific signs of chronic inflammation, a significant decrease in the amount of elastin within the tarsal plate and eyelid skin as compared with controls.
  • [MeSH-major] Eyelid Diseases / enzymology. Matrix Metalloproteinases / metabolism
  • [MeSH-minor] Aged. Biopsy. Carcinoma, Basal Cell. Elastic Tissue / enzymology. Elastic Tissue / ultrastructure. Elastin / metabolism. Eyelid Neoplasms. Female. Humans. Immunoenzyme Techniques. Male. Matrix Metalloproteinase 12. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 7 / metabolism. Matrix Metalloproteinase 9 / metabolism. Metalloendopeptidases / metabolism. Middle Aged. Retrospective Studies. Syndrome

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  • (PMID = 15808264.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-58-3 / Elastin; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.65 / MMP12 protein, human; EC 3.4.24.65 / Matrix Metalloproteinase 12
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18. Jakobiec FA, Hanna E, Townsend DJ: Basal cell carcinoma of the eyelid with exceptional histomorphologic expressions. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):232-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma of the eyelid with exceptional histomorphologic expressions.
  • A basal cell carcinoma of the eyelid had unique and potentially confusing histopathologic features.
  • The tumor displayed a carcinoma in situ pattern with replacement of an extensive segment of the tarsal epithelium by neoplastic basaloid cells, a finding to the best of the authors' knowledge that has not been previously documented.
  • Within the infiltrating component of the dermis were classical solid basaloid nests and lobules; they were accompanied, however, by a separate and exceptionally prominent component of duct-like (pseudoglandular) units mimicking a microcystic adnexal carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 19454940.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Al-Buloushi A, Filho JP, Cassie A, Arthurs B, Burnier MN Jr: Basal cell carcinoma of the eyelid in children: a report of three cases. Eye (Lond); 2005 Dec;19(12):1313-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma of the eyelid in children: a report of three cases.
  • Basal cell carcinoma is the most common eyelid malignancy, accounting for approximately 90% of malignant eyelid tumours.
  • We report three cases of de novo basal cell carcinoma in children.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 15650761.001).
  • [ISSN] 0950-222X
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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20. Cunneen TS, Yong JL, Benger R: Lung metastases in a case of metatypical basal cell carcinoma of the eyelid: an illustrative case and literature review to heighten vigilance of its metastatic potential. Clin Exp Ophthalmol; 2008 Jul;36(5):475-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung metastases in a case of metatypical basal cell carcinoma of the eyelid: an illustrative case and literature review to heighten vigilance of its metastatic potential.
  • Basal cell carcinoma (BCC) is an extremely common malignancy; however, unlike other skin cancers, they very rarely metastasize.
  • Here we present an unusual case of metatypical BCC of the eyelid which metastasized to the lung nine years after initial surgical treatment.
  • We include a review of the literature regarding metastatic BCC and suggest that metatypical features in primary BCC should prompt careful patient monitoring and consideration of adjuvant treatment at the time of diagnosis.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / secondary. Eyelid Neoplasms / pathology. Lung Neoplasms / pathology. Lung Neoplasms / secondary

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  • (PMID = 18925916.001).
  • [ISSN] 1442-9071
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 13
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21. Konstantinidis A, Ghosh Y, Snead D, Ahluwalia H: Eyelid basal cell carcinoma with osteosarcomatous changes. Ophthal Plast Reconstr Surg; 2008 Jul-Aug;24(4):322-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid basal cell carcinoma with osteosarcomatous changes.
  • An 80-year-old woman presented with a lump in her left lower eyelid.
  • Histopathology of the lesion supported the diagnosis of basal cell carcinoma with osteosarcomatous changes.
  • The lesion was fully excised and the eyelid was reconstructed with a Hughes flap.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Aged, 80 and over. Blepharoplasty. Cell Differentiation. Female. Humans. Reconstructive Surgical Procedures

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  • (PMID = 18645447.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Jakobiec FA, Zakka FR, Hatton MP: Eyelid basal cell carcinoma developing in an epidermoid cyst: a previously unreported event. Ophthal Plast Reconstr Surg; 2010 Nov-Dec;26(6):491-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid basal cell carcinoma developing in an epidermoid cyst: a previously unreported event.
  • A 72-year-old woman presented with a 3 × 2 × 1-mm right lower eyelid micronodular, whitish solid lesion at the nasal eyelid margin that had caused madarosis.
  • Local excision led to the microscopic discovery of 2 epidermoid cysts, one of which harbored a basal cell carcinoma arising from its orthokeratinizing squamous cell lining.
  • BER-EP4-positive immunostaining confirmed the basal cell nature of the neoplasm.
  • This is the first example in the eyelid of an epidermoid cyst displaying malignant transformation.
  • No matter how innocent they may appear, all small cystic or noncystic eyelid lesions should be submitted for pathologic evaluation.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Cell Transformation, Neoplastic / pathology. Epidermal Cyst / pathology. Eyelid Diseases / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 20736874.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / human epithelial antigen-125
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23. Zhao TL, Cheng XD, Ge SX, Wang HG, Li XW: [Clinic application of compound flap pedicled with arterial arch of palpebral margin]. Zhonghua Zheng Xing Wai Ke Za Zhi; 2006 Nov;22(6):439-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To study the clinic application of compound flap pedicled with arterial arch of palpebral margin in repairing severe full defect of eyelid.
  • METHODS: According to eyelid structure and the defect size, the two compound flaps were designed beside the defect based on the arterial arch of the palpebral margin.
  • If the defective area was too large, the lateral compound flap may be extended to lower or upper eyelid 0.5 cm away from the outer canthus, then cut and propelled the two compound flaps to repair the full eyelid defect.
  • In this cases, 4 cases were basal cell carcinoma of eyelid, 2 cases were squamous carcinoma, 3 angiomas, 6 chromatophore nexuses, 3 traumatic defects, 2 congenital defects.
  • The largest length of eyelid full defect was 1.7 cm and the smallest was 0.8 cm.
  • 6 cases were upper eyelid defect and 14 cases were lower eyelid defect.
  • CONCLUSIONS: Repairing full eyelid defect with the compound eyelid flap is the same kind tissue repairing.
  • It can not only provide enough tissues to primary repair large full defect of the upper or lower eyelid to restore normal anatomical structure and appearance of the eyelid, but also is easy to be operated without severe secondary deformities.
  • It is an ideal method of repairing the eyelid defect.

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  • (PMID = 17286003.001).
  • [ISSN] 1009-4598
  • [Journal-full-title] Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
  • [ISO-abbreviation] Zhonghua Zheng Xing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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24. Bonanno A, Esmaeli B, Fingeret MC, Nelson DV, Weber RS: Social challenges of cancer patients with orbitofacial disfigurement. Ophthal Plast Reconstr Surg; 2010 Jan-Feb;26(1):18-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Three patients had adenoid cystic carcinoma of lacrimal gland, 3 had squamous cell carcinoma of conjunctiva/eyelid, and 1 each had conjunctival melanoma, eyelid sebaceous gland carcinoma, transitional cell carcinoma of lacrimal sac, adenocarcinoma of orbit, neuroendocrine carcinoma of orbit, and basal cell carcinoma of eyelid.

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  • (PMID = 20090478.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Yang R, Yang J, Wang F: [Reconstruction of eyelid with hard palate mucosa autograft after resection of Malignant tumor of eyelid]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2006 May;20(5):519-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Reconstruction of eyelid with hard palate mucosa autograft after resection of Malignant tumor of eyelid].
  • OBJECTIVE: To evaluate the clinical effect of the eyelid reconstruction using hard palate mucosa graft after resection of malignant tumor of eyelid.
  • METHODS: From January 1998 to October 2003, 18 cases of malignant tumor of eyelid underwent the eyelid reconstruction with local flap grafting and hard palate mucosa autotransplantation.
  • The defect was caused by basal cell carcinoma of eyelid in 10 cases, by carcinoma of meibomian glands in 6 cases and by squamous cell carcinoma of eyelid in 2 cases, including 12 cases of complete eyelid defect and 6 cases of 2/3 eyelid defect.
  • RESULTS: The appearance and function of the eyelid in all cases were almost normal after the eyelid reconstruction with hard palate mucosa autotransplantation in replacing posterior layer of eyelid.
  • The complete eyelid closure and no entropion were observed in all cases.
  • CONCLUSION: The eyelid reconstruction using autotransplantation with hard palate mucosa in replacing posterior layer of eyelid was easy-to-operate and has satisfactory clinical effect.
  • [MeSH-minor] Adult. Aged. Eyelid Neoplasms / surgery. Female. Humans. Male. Middle Aged. Palate, Hard. Postoperative Period. Transplantation, Autologous

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  • (PMID = 16752838.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Tawfik HA, Assem M, Elkafrawy MH, Talib NM: Scar sarcoidosis developing 16 years after complete excision of an eyelid Basal carcinoma. Orbit; 2008;27(6):438-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Scar sarcoidosis developing 16 years after complete excision of an eyelid Basal carcinoma.
  • A 56-year-old patient developed sarcoidosis on top of an old eyelid scar from previous removal of an eyelid basal cell carcinoma 16 years prior to presentation.
  • Sarcoidosis should be considered in the differential diagnosis of recurrent eyelid skin cancers especially if the external appearance or the duration after the initial surgery does not fit the criteria for recurrence.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery. Postoperative Complications. Sarcoidosis / etiology
  • [MeSH-minor] Cicatrix / diagnosis. Cicatrix / etiology. Diagnosis, Differential. Female. Humans. Middle Aged. Ophthalmologic Surgical Procedures

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  • (PMID = 19085299.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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27. Prabhakaran VC, Gupta A, Huilgol SC, Selva D: Basal cell carcinoma of the eyelids. Compr Ophthalmol Update; 2007 Jan-Feb;8(1):1-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma of the eyelids.
  • Basal cell carcinoma is the most common malignancy in humans, and it is also the most frequent periocular malignancy.
  • In this review, we discuss the risk factors, pathology, molecular biology, clinical features, and management of eyelid basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell. Eyelid Neoplasms
  • [MeSH-minor] Australia / epidemiology. Combined Modality Therapy. Diagnosis, Differential. Humans. Incidence. Neoplasm Invasiveness. Orbital Neoplasms / pathology

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  • [CommentIn] Compr Ophthalmol Update. 2007 Jan-Feb;8(1):15-6 [17394755.001]
  • (PMID = 17394754.001).
  • [ISSN] 1527-7313
  • [Journal-full-title] Comprehensive ophthalmology update
  • [ISO-abbreviation] Compr Ophthalmol Update
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 119
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28. Blasi MA, Giammaria D, Balestrazzi E: Immunotherapy with imiquimod 5% cream for eyelid nodular basal cell carcinoma. Am J Ophthalmol; 2005 Dec;140(6):1136-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunotherapy with imiquimod 5% cream for eyelid nodular basal cell carcinoma.
  • PURPOSE: To evaluate the efficacy and safety of topical imiquimod 5% cream for the treatment of eyelid basal cell carcinoma.
  • METHODS: Imiquimod 5% cream was applied topically once daily, 3 days a week for 8 to 12 weeks, in two patients affected by eyelid nodular basal cell carcinoma.
  • CONCLUSIONS: Topical imiquimod 5% cream seems to be a useful treatment for eyelid nodular basal cell carcinoma in selected cases, but further long-term studies are needed to assess the efficacy and safety of this approach.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Basal Cell / drug therapy. Eyelid Neoplasms / drug therapy. Immunotherapy. Interferon Inducers / therapeutic use

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  • (PMID = 16376667.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Interferon Inducers; 0 / Ointments; 99011-02-6 / imiquimod
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29. Toth J, Lukats O, Pecorella I: Cbfa1/Runx2 expression in an ossifying basal cell carcinoma of the eyelid. Arch Dermatol Res; 2010 Nov;302(9):695-700

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cbfa1/Runx2 expression in an ossifying basal cell carcinoma of the eyelid.
  • A case of basal cell carcinoma (BCC) with intratumoural bone formation affecting the eyelid of a 77-year-old lady is described.
  • [MeSH-major] Antigens, Differentiation / metabolism. Carcinoma, Basal Cell / metabolism. Core Binding Factor Alpha 1 Subunit / metabolism. Eyelid Neoplasms / metabolism. Osteoblasts / metabolism

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  • [ErratumIn] Arch Dermatol Res. 2013 Jul;305(5):461. Jeannette, Toth [corrected to Toth, Jeannette]; Olga, Lukats [corrected to Lukats, Olga]; Irene, Pecorella [corrected to Pecorella, Irene]
  • (PMID = 20658243.001).
  • [ISSN] 1432-069X
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Core Binding Factor Alpha 1 Subunit
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30. Ross AH, Kennedy CT, Collins C, Harrad RA: The use of imiquimod in the treatment of periocular tumours. Orbit; 2010 Apr;29(2):83-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present a retrospective case series of 5 patients who received topical Imiquimod for various eyelid tumours.
  • Two patients were diagnosed with basal cell carcinoma of the eyelid, one patient with actinic keratosis, one with intraepidermal squamous cell carcinoma (Bowen's disease) and one patient had concomitant squamous cell carcinoma and intraepidermal squamous cell carcinoma.
  • RESULTS: All 5 patients, with various eyelid neoplastic/pre-neoplastic pathology, responded well with clinical resolution, to treatment with topical Imiquimod.
  • In our experience, it is a safe and effective treatment for periocular lesions, including actinic keratosis, intraepidermal squamous cell carcinoma, basal cell carcinoma and squamous cell carcinoma.
  • To our knowledge, this is the first published description of the successful use of 5% Imiquimod in treating moderately differentiated squamous cell carcinoma of the eyelid.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Eyelid Neoplasms / drug therapy. Keratosis, Actinic / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Administration, Topical. Aged. Bowen's Disease / drug therapy. Bowen's Disease / pathology. Carcinoma, Basal Cell / drug therapy. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Ophthalmic Solutions. Retrospective Studies. Treatment Outcome

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  • (PMID = 20394545.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Ophthalmic Solutions; 99011-02-6 / imiquimod
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31. Barnes EA, Dickinson AJ, Langtry JA, Lawrence CM: Eyelid basal cell carcinoma. Br J Ophthalmol; 2006 Jul;90(7):926; author reply 926-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Eyelid Neoplasms / surgery

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  • [Cites] Plast Reconstr Surg. 1984 Mar;73(3):492-7 [6701225.001]
  • [Cites] Ophthalmology. 2004 Apr;111(4):631-6 [15051193.001]
  • [Cites] Br J Ophthalmol. 2005 Aug;89(8):992-4 [16024851.001]
  • [Cites] Br J Plast Surg. 1993 Oct;46(7):599-606 [8252270.001]
  • [Cites] J Am Acad Dermatol. 1998 Nov;39(5 Pt 1):698-703 [9810885.001]
  • [CommentOn] Br J Ophthalmol. 2005 Aug;89(8):992-4 [16024851.001]
  • (PMID = 16782962.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1857169
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32. Mohammadi A, Rosa M, Rhatigan R: Eyelid basal cell carcinoma associated with solitary neurofibroma. J Cutan Pathol; 2010 Jun;37(6):707-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eyelid basal cell carcinoma associated with solitary neurofibroma.
  • [MeSH-major] Carcinoma, Basal Cell / complications. Eyelid Neoplasms / complications. Neurofibroma / complications

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  • (PMID = 19614728.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Denmark
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