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1. Archontaki M, Stavrianos SD, Korkolis DP, Arnogiannaki N, Vassiliadis V, Liapakis IE, Christ H, Rapidis AD, Kokkalis G: Giant Basal cell carcinoma: clinicopathological analysis of 51 cases and review of the literature. Anticancer Res; 2009 Jul;29(7):2655-63
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant Basal cell carcinoma: clinicopathological analysis of 51 cases and review of the literature.
  • BACKGROUND: Giant basal cell carcinoma (GBCC) is an aggressive malignant neoplasm.
  • It develops as long-standing dermal tumor with mean disease duration of 14.5 years and is most commonly located on the back, followed by the face and upper extremity.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 19596942.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Number-of-references] 54
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2. Lo Muzio L: Nevoid basal cell carcinoma syndrome (Gorlin syndrome). Orphanet J Rare Dis; 2008;3:32
Genetic Alliance. consumer health - Nevoid basal cell carcinoma syndrome.

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  • [Title] Nevoid basal cell carcinoma syndrome (Gorlin syndrome).
  • Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is a hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms.
  • Main clinical manifestations include multiple basal cell carcinomas (BCCs), odontogenic keratocysts of the jaws, hyperkeratosis of palms and soles, skeletal abnormalities, intracranial ectopic calcifications, and facial dysmorphism (macrocephaly, cleft lip/palate and severe eye anomalies).
  • BCCs (varying clinically from flesh-colored papules to ulcerating plaques and in diameter from 1 to 10 mm) are most commonly located on the face, back and chest.
  • [MeSH-major] Basal Cell Nevus Syndrome

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  • (PMID = 19032739.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 164
  • [Other-IDs] NLM/ PMC2607262
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3. Rieger UM, Schlecker C, Pierer G, Haug M: Spontaneous regression of two giant basal cell carcinomas in a single patient after incomplete excision. Tumori; 2009 Mar-Apr;95(2):258-63
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  • [Title] Spontaneous regression of two giant basal cell carcinomas in a single patient after incomplete excision.
  • BACKGROUND: Spontaneous regression of small basal cell carcinoma has been reported.
  • For giant basal cell carcinoma, however, no spontaneous regression has been described to date.
  • CASE REPORT: We present a patient with two independent giant basal cell carcinomas over the left clavicle and the lower back, measuring 7 x 12 cm and 18 x 20 cm, respectively.
  • CONCLUSION; Incompletely excised giant basal cell carcinomas can regress spontaneously.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Materia Medica / therapeutic use. Neoplasm Regression, Spontaneous. Skin Neoplasms / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Back. Clavicle / pathology. Humans. Lumbar Vertebrae / pathology. Male. Neoplasm Invasiveness. Spinal Neoplasms / secondary. Wound Healing / drug effects

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  • (PMID = 19579878.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Materia Medica
  • [Number-of-references] 51
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4. Tang XH, Su D, Albert M, Scognamiglio T, Gudas LJ: Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther; 2009 Jul;8(13):1212-3
Hazardous Substances Data Bank. 4-NITROQUINOLINE-N-OXIDE .

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  • [Title] Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen.
  • We targeted human LRAT expression specifically to the basal layer of mouse skin and oral cavity epithelia by using a portion of the human cytokeratin 14 (K14) promoter.
  • The retinyl ester levels in skin of LRAT TG+ mice were 32% +/- 5.4% greater than those in TG- mice, and topical treatment of the back skin with retinol resulted in greater increases in retinyl esters (from 6.9- to 14.3-fold in different TG+ mice) in TG+ mouse skin than in TG- mouse skin (1.3 fold).
  • While carcinogen (4-NQO) treatment induced multifocal precancerous and cancer lesions in the tongues of both TG positive (n=16) and negative mice (n=22), higher percentages of transgenic positive mice (62.5%) developed more severe tongue lesions (grades 3 and 4) than transgenic negative mice (24.8%) after 4-NQO treatment (p < 0.05).
  • Carcinogen treatment also resulted in greater percentages of transgenic positive mouse tongues with hyperplasia (71.4%), dysplasia (85.7%, p < 0.05), and carcinoma (28.6%) than transgenic negative mouse tongues (53.3%, 46.7%, and 20%, respectively).
  • Taken together, these data show that overexpression of human LRAT specifically in oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis.

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  • (PMID = 19471114.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / DE010389-15; United States / NCI NIH HHS / CA / T32 CA062948; United States / NIDCR NIH HHS / DE / R01DE10389; United States / NIDCR NIH HHS / DE / R01 DE010389-15; United States / NIDCR NIH HHS / DE / R01 DE010389
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Proliferating Cell Nuclear Antigen; 0 / Receptors, Retinoic Acid; 0 / Retinoids; 136601-57-5 / Cyclin D1; 56-57-5 / 4-Nitroquinoline-1-oxide; EC 1.14.99.- / Ptgs2 protein, mouse; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.3.- / Acyltransferases; EC 2.3.1.- / lecithin-retinol acyltransferase
  • [Other-IDs] NLM/ NIHMS209419; NLM/ PMC2882701
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5. Fresini A, Rossiello L, Severino BU, Del Prete M, Satriano RA: Giant basal cell carcinoma. Skinmed; 2007 Jul-Aug;6(4):204-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant basal cell carcinoma.
  • A 72-year-old white man presented with a large cutaneous tumor on his back.
  • Therefore, a diagnosis of basal cell carcinoma, adenoid subtype, was made.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 17618177.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Bogdanić B, Smud S, Bagatin D, Nola M, Mijatović D, Majerović M: Giant basal cell carcinoma of the back: a case report and review of the literature. Coll Antropol; 2009 Mar;33(1):315-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant basal cell carcinoma of the back: a case report and review of the literature.
  • Basal cell carcinoma (BCC) is the most common cutaneous malignancy and the most common human malignancy in general.
  • Out of all basal cell carcinomas, giant basal cell carcinoma represents less than 1%.
  • Only 10% of all basal cell carcinomas are located on the trunk and majority is located on the head and neck.
  • We describe a patient with a exophytic giant basal cell carcinoma of the back size 8.5 x 8 x 6 cm, infiltrating skin 1.5 cm.
  • Review of the literature that refers to giant basal cell carcinoma was carried out.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 19408644.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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7. Monarca C, Chiummariello S, Mazzana P, Rizzo MI, Alfano C, Scuderi N: [Oncological and reconstructive management in a patient with multiple recurrences of basal cell carcinoma of the nose]. G Chir; 2008 Mar;29(3):89-91
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  • [Title] [Oncological and reconstructive management in a patient with multiple recurrences of basal cell carcinoma of the nose].
  • [Transliterated title] Management oncologico e ricostruttivo nella recidiva multipla del carcinoma basocellulare del naso.
  • Basal cell carcinoma (BCC) grows by direct extension replacing local anatomical structure; it rarely metastasizes, however may cause severe injure expanding to contiguous tissues with a biological invasive behaviour.
  • Fast cancer extension to the adjacent facial structures requires wide resection for oncological management.
  • In our study we present a 69-year-old male affected by BCC of the nose back and treated by surgical radical excision with free margin disease at histological examination.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Neoplasm Recurrence, Local / surgery. Nose Neoplasms / surgery

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  • (PMID = 18366887.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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8. Abiatari I, DeOliveira T, Kerkadze V, Schwager C, Esposito I, Giese NA, Huber P, Bergman F, Abdollahi A, Friess H, Kleeff J: Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. Mol Cancer Ther; 2009 Jun;8(6):1494-504
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Consensus transcriptome signature of perineural invasion in pancreatic carcinoma.
  • Perineural invasion, the growth of tumor cells along nerves, is a key feature of pancreatic cancer.
  • The cardinal symptom of pancreatic cancer, abdominal pain often radiating to the back, as well as the high frequency of local tumor recurrence following resection are both attributed to the unique ability of pancreatic tumor cells to invade the neuronal system.
  • In this study, we developed a novel method to monitor ex vivo perineural invasion into surgically resected rat vagal nerves by different human pancreatic tumor cell lines.
  • We found significant up-regulation of KIF14 and ARHGDIbeta mRNA levels in patients with pancreatic cancer, and both proteins were differentially expressed in tumor cells invading the perineural niche of pancreatic cancer patients as detected by immunohistochemistry.
  • Moreover, functional knockdown of KIF14 and ARHGDIbeta using small interfering RNA resulted in altered basal and/or perineural invasion of pancreatic tumor cells.
  • Our work provides novel insights into the molecular determinants of perineural invasion in pancreatic cancer.
  • The established nerve invasion model and the consensus signature of perineural invasion could be instrumental in the identification of novel therapeutic targets of pancreatic cancer as exemplified by KIF14 and ARHGDIbeta.
  • [MeSH-major] Cell Movement / physiology. Gene Expression Profiling. Pancreatic Neoplasms / genetics. Vagus Nerve / physiology
  • [MeSH-minor] Animals. Anoikis. Cell Line, Tumor. Cell Proliferation. Cluster Analysis. Gene Expression Regulation, Neoplastic. Guanine Nucleotide Dissociation Inhibitors / genetics. Guanine Nucleotide Dissociation Inhibitors / metabolism. Humans. Immunoblotting. Immunohistochemistry. Kinesin / genetics. Kinesin / metabolism. Neoplasm Invasiveness. Oligonucleotide Array Sequence Analysis. Oncogene Proteins / genetics. Oncogene Proteins / metabolism. RNA Interference. Rats. Reverse Transcriptase Polymerase Chain Reaction. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism. rho-Specific Guanine Nucleotide Dissociation Inhibitors

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  • (PMID = 19509238.001).
  • [ISSN] 1538-8514
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Guanine Nucleotide Dissociation Inhibitors; 0 / Oncogene Proteins; 0 / Tumor Suppressor Proteins; 0 / rho-Specific Guanine Nucleotide Dissociation Inhibitors; EC 3.6.1.- / KIF14 protein, human; EC 3.6.1.- / Kinesin
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9. Betti R, Menni S, Radaelli G, Bombonato C, Crosti C: Micronodular basal cell carcinoma: a distinct subtype? Relationship with nodular and infiltrative basal cell carcinomas. J Dermatol; 2010 Jul;37(7):611-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Micronodular basal cell carcinoma: a distinct subtype? Relationship with nodular and infiltrative basal cell carcinomas.
  • Micronodular basal cell carcinoma (BCC) may be more difficult to eradicate and prone to recurrence than nodular subtype.
  • The aim of the study was to compare anatomical and histological characteristics of the basal cell carcinomas subtypes and the relationship of the micronodular BCC with other subtypes.
  • The location was head/neck, limbs, chest/abdomen, back or genitals.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Nose Neoplasms / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 20629826.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Braun-Falco M: Combined malignant melanoma and basal cell carcinoma tumor of the intermingled type. J Cutan Pathol; 2007 Sep;34(9):731-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined malignant melanoma and basal cell carcinoma tumor of the intermingled type.
  • BACKGROUND: The combination of malignant melanoma (MM) and basal cell carcinoma (BCC) within a single tumor is an unusual finding.
  • CASE REPORT: An 84-year-old white man with a pigmented tumor on the back showing a combination of MM and BCC.
  • RESULTS: A 1.5 x 1.5-cm irregular brown lesion on the back was clinically suggestive of MM.
  • CONCLUSION: By reviewing the low number of published cases, we found that a combined MM-BCC tumor exists in two variants: a collision type in which components of each cell type are clearly demarcated and an intermingled type in which both cell types grow intimately together.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Melanoma / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 17696923.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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11. Montgomery L, Macpherson M, Gerig L, Carty K, Fox G, Esche B, Clark BG: Simultaneous treatment of multiple basal cell carcinoma lesions. Br J Radiol; 2008 Dec;81(972):e290-2
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous treatment of multiple basal cell carcinoma lesions.
  • We present a rare case of advanced basal cell carcinoma where multiple large lesions, located on the anterior chest wall and back, were treated simultaneously using tomotherapy (TomoTherapy HiArt; TomoTherapy Inc, Madison, WI).
  • [MeSH-major] Carcinoma, Basal Cell / radiotherapy. Neoplasms, Multiple Primary / radiotherapy. Skin Neoplasms / radiotherapy

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  • (PMID = 19029050.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. McGregor DH, Cherian R, Romanas MM, Ulusarac O, Mathur SC, Feldman MM: Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma. Ann Clin Lab Sci; 2008;38(2):157-62
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma.
  • We report 2 cases of collision tumors involving amelanotic malignant melanoma of the back.
  • One patient is a 79-yr-old male with an 8.7 x 5.5 x 4.5 cm polypoid lesion that on shave biopsy was diagnosed as basal cell carcinoma.
  • Subsequent excision showed that the lesion was largely composed of amelanotic melanoma underlying a relatively small and thin basal cell carcinoma, and this probably would have been demonstrated in a punch (rather than shave) biopsy.
  • The other patient is a 71-yr-old male with a 1 cm exophytic lesion on the back, which was determined microscopically to be melanoma, and a 0.6 cm papule on the back.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma, Amelanotic / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18469362.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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13. Arits AH, Parren LJ, van Marion AM, Sommer A, Frank J, Kelleners-Smeets NW: Basal cell carcinoma and trichoepithelioma: a possible matter of confusion. Int J Dermatol; 2008 Nov;47 Suppl 1:13-7
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell carcinoma and trichoepithelioma: a possible matter of confusion.
  • Difficulty in differentiation between a solitary basal cell carcinoma, which is known as a malign skin lesion and a benign trichoepithelioma, is a frequent problem in all day dermatologic practice.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Back. Biopsy. Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 18986478.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Lane JE, Allen JH, Lane TN, Lesher JL Jr: Unilateral Basal cell carcinomas: an unusual entity treated with photodynamic therapy. J Cutan Med Surg; 2005 Dec;9(6):336-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral Basal cell carcinomas: an unusual entity treated with photodynamic therapy.
  • BACKGROUND: Unilateral localized basal cell carcinomas are an uncommon finding that presents both a diagnostic and therapeutic challenge.
  • Exclusion of unilateral nevoid basal cell carcinoma syndrome is indicated.
  • OBJECTIVE: We present a patient with unilateral localized basal cell carcinomas who was successfully treated with photodynamic therapy.
  • The topical solution was applied to the patient's back and illuminated the following day via the BLU-U Blue Light Illuminator.
  • The patient had an excellent therapeutic response with no clinically apparent basal cell carcinomas for 18 months.
  • CONCLUSIONS: We report a patient with unilateral basal cell carcinomas successfully treated with photodynamic therapy.
  • This uncommon entity represents a diagnostic challenge in its inherent absence of the classic clinical and radiographic findings of nevoid basal cell carcinoma syndrome.
  • Like nevoid basal cell carcinoma syndrome, unilateral basal cell carcinomas poses a therapeutic challenge with the sheer number of cutaneous tumors.
  • [MeSH-major] Aminolevulinic Acid / therapeutic use. Carcinoma, Basal Cell / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy
  • [MeSH-minor] Basal Cell Nevus Syndrome / diagnosis. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged. Time Factors. Treatment Outcome

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  • (PMID = 16699902.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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15. Caekelbergh K, Nikkels AF, Leroy B, Verhaeghe E, Lamotte M, Vincent R: Photodynamic therapy using methyl aminolevulinate in the management of primary superficial basal cell carcinoma: clinical and health economic outcomes. J Drugs Dermatol; 2009 Nov;8(11):992-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic therapy using methyl aminolevulinate in the management of primary superficial basal cell carcinoma: clinical and health economic outcomes.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common form of skin cancer worldwide.
  • The mean number of lesions per patient was 1.6, mostly located on the face, the back and the chest.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Carcinoma, Basal Cell / drug therapy. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 19894366.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / methyl 5-aminolevulinate; 88755TAZ87 / Aminolevulinic Acid
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16. Betti R, Radaelli G, Bombonato C, Crosti C, Cerri A, Menni S: Anatomic location of Basal cell carcinomas may favor certain histologic subtypes. J Cutan Med Surg; 2010 Nov-Dec;14(6):298-302
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anatomic location of Basal cell carcinomas may favor certain histologic subtypes.
  • BACKGROUND: Differences in age, site, and subtype exist in basal cell carcinoma (BCC).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Back. Cohort Studies. Extremities. Female. Genitalia. Humans. Male. Middle Aged. Thorax

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  • (PMID = 21084023.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Li N, Wolgamot G, Argenyi Z: Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma. J Cutan Pathol; 2007 May;34(5):410-4
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma.
  • Although primary cutaneous neuroendocrine cell carcinoma [Merkel cell carcinoma (MCC)] may show divergent features, including microcystic ('tubuloglandular'), squamous, eccrine and rhabdomyoblastic, a diffuse microcystic pattern is exceedingly rare.
  • Both patients were middle-aged men with a history of rapidly growing plaques of the back or posterior neck.
  • Although the lack of CK20 staining is unusual, the histologic characteristics along with the remaining immunohistochemical studies favor the diagnosis of a primary cutaneous neuroendocrine cell carcinoma over the variants of eccrine carcinoma or basal cell carcinoma with neuroendocrine differentiation.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 17448197.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Betti R, Radaelli G, Mussino F, Menni S, Crosti C: Anatomic location and histopathologic subtype of basal cell carcinomas in adults younger than 40 or 90 and older: any difference? Dermatol Surg; 2009 Feb;35(2):201-6
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  • [Title] Anatomic location and histopathologic subtype of basal cell carcinomas in adults younger than 40 or 90 and older: any difference?
  • BACKGROUND: Differences in age, site, and histopathologic subtype exist in basal cell carcinoma (BCC).
  • [MeSH-major] Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Head and Neck Neoplasms / epidemiology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology
  • [MeSH-minor] Abdomen. Adult. Age Distribution. Age Factors. Aged, 80 and over. Arm. Back. Female. Humans. Incidence. Leg. Male. Prevalence. Regression Analysis. Sex Distribution. Thorax

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  • (PMID = 19215256.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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19. Plaza JA, Ortega PF, Bengana C, Stockman DL, Suster S: Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases. Am J Dermatopathol; 2010 Oct;32(7):683-7
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  • [Title] Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases.
  • When the morphologic distinction between basal cell carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two neoplasms from each other.
  • Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous neoplasms, such as adnexal tumors, squamous cell carcinomas, etc.
  • Of the 27 cases of BCC, 18 cases were located in the head and neck area, 5 on upper extremities, and 4 on the back.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Membrane Glycoproteins / biosynthesis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20559122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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20. Bergman A, Contard P, Spencer J: Multiple basal cell carcinomas in a young adult treated with imiquimod 5%: a case report and literature review. J Drugs Dermatol; 2005 Jan-Feb;4(1):95-7
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  • [Title] Multiple basal cell carcinomas in a young adult treated with imiquimod 5%: a case report and literature review.
  • We present a case of basal cell carcinoma that is unique in the literature with regard to the rare combination of age of onset and number of BCCs at initial presentation that was successfully treated with imiquimod 5%.
  • Physical exam was remarkable for seven pink translucent skin lesions on the forehead, alar ridge, zygoma, and upper back.
  • Shave biopsies revealed basal cell carcinoma in all 7 lesions.
  • The presentation of this number of de novo BCCs in a patient this young in absence of a known BCC syndrome has, to the best of our knowledge, not previously been reported in the literature and was successfully treated with imiquimod 5%.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Basal Cell / drug therapy. Skin Neoplasms / drug therapy

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  • (PMID = 15696993.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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21. Kiyohara T, Kumakiri M, Kuwahara H, Saitoh A, Ansai S: Rippled-pattern sebaceoma: a report of a lesion on the back with a review of the literature. Am J Dermatopathol; 2006 Oct;28(5):446-8
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  • [Title] Rippled-pattern sebaceoma: a report of a lesion on the back with a review of the literature.
  • A 68-year-old Japanese man presented with a nodule that had been present for 5 to 6 years on the right side of the back.
  • The present case is the first reported rippled-pattern sebaceous neoplasm on the back.
  • Many spindle cell tumors, such as basal cell carcinoma, pleomorphic adenoma, dermatofibrosarcoma protuberans, myofibroblastoma, and leiomyoblastoma, in addition to trichoblastoma and sebaceoma, can have a rippled-pattern.
  • [MeSH-major] Back. Hair Follicle / pathology. Neoplasms, Basal Cell / pathology. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17012924.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 23
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22. Skroza N, Panetta C, Schwartz RA, Balzani A, Rota C, Buccheri EM, Alfano C, Innocenzi D: Giant meta-typical carcinoma: an unusual tumor. Acta Dermatovenerol Croat; 2006;14(1):46-51
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  • [Title] Giant meta-typical carcinoma: an unusual tumor.
  • Meta-typical carcinoma (MTC) or basosquamous carcinoma is a remarkable malignancy with features of both basal and squamous cell carcinoma.
  • It is typically located on the back and face, often with clinical features of basal cell carcinoma but tending to be more aggressive with enhanced prospects of lymph node or distant metastases.
  • Our report describes a huge neglected MTC of the back of ten-year duration, a giant ulcero-vegetative tumor measuring 20 x 25 cm.
  • Histologic examination of specimens from the margins and periphery revealed aspects of both basal and squamous cell carcinoma, while the ulcerated center showed sclerotic tissue without tumor.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16603102.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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23. Oster-Schmidt C, Dirschka T: Therapy of cutaneous squamous cell carcinoma in two retirement home residents. J Dtsch Dermatol Ges; 2005 Sep;3(9):705-8
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  • [Title] Therapy of cutaneous squamous cell carcinoma in two retirement home residents.
  • The incidence of cutaneous squamous cell carcinomas (SCC) has been increasing by about 5% per year of the past 40 years in a population which is growing continuously older and as such presents a growing therapeutic challenge.
  • We report on two elderly female residents of a retirement home with histologically confirmed SCC on the back of the hand.
  • Imiquimod 5% cream was approved last year for the treatment of superficial basal cell carcinoma.
  • [MeSH-major] Adjuvants, Immunologic / therapeutic use. Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / therapy. Hand Dermatoses / therapy. Skin Neoplasms / therapy. Surgical Flaps

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  • (PMID = 16189865.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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24. Harvey AM, Grice B, Hamilton C, Truong LD, Ro JY, Ayala AG, Zhai QJ: Diagnostic utility of P504S/p63 cocktail, prostate-specific antigen, and prostatic acid phosphatase in verifying prostatic carcinoma involvement in seminal vesicles: a study of 57 cases of radical prostatectomy specimens of pathologic stage pT3b. Arch Pathol Lab Med; 2010 Jul;134(7):983-8
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  • [Title] Diagnostic utility of P504S/p63 cocktail, prostate-specific antigen, and prostatic acid phosphatase in verifying prostatic carcinoma involvement in seminal vesicles: a study of 57 cases of radical prostatectomy specimens of pathologic stage pT3b.
  • CONTEXT: Seminal vesicle invasion by prostatic carcinoma is directly associated with tumor staging; verification is challenging when the tumor demonstrates cribriform or papillary growth patterns or there are back-to-back small-gland proliferations.
  • P504S is overexpressed in prostatic carcinoma and high-grade prostatic intraepithelial neoplasia with cytoplasmic immunoreactivity. p63 has positive immunoreactivity in basal cell nuclei of benign prostatic glands.
  • OBJECTIVE: To evaluate the usefulness of a single-color P504S/p63 cocktail immunostain in verifying prostatic carcinoma within the seminal vesicle.
  • DESIGN: Sections from 57 radical prostatectomy specimens of pathologic stage pT3b that contain seminal vesicle with prostatic carcinoma involvement were immunostained with primary antibodies against prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) and a cocktail of antibodies against P504S and p63.
  • RESULTS: Prostatic carcinoma cells from all 57 cases were diffusely positive for P504S, PSA, and PAP with cytoplasmic staining and no p63 nuclear staining.
  • Seminal vesicle epithelium from all 57 cases was negative for all 3 markers with distinct p63 nuclear staining of the basal cells.
  • CONCLUSIONS: The P504S/p63 one-color cocktail is a practical and cost-effective stain to differentiate prostatic carcinoma that involves the seminal vesicle from seminal vesicle epithelium.
  • [MeSH-major] Carcinoma / diagnosis. Membrane Proteins / analysis. Prostate-Specific Antigen / analysis. Prostatic Neoplasms / diagnosis. Protein Tyrosine Phosphatases / analysis. Racemases and Epimerases / analysis. Seminal Vesicles / chemistry

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  • (PMID = 20586625.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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25. Fincher EF, Gladstone HB: Dual transposition flaps for the reconstruction of large scalp defects. J Am Acad Dermatol; 2009 Jun;60(6):985-9

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  • We present a dual transposition flap to close a large defect following Mohs surgery for a basal cell carcinoma on the scalp.
  • METHODS: We describe and report the case of a man with a basal cell carcinoma on the scalp vertex who had been referred for Mohs micrographic surgery.
  • It resulted in minimal alopecia, minimal distortion of the hair orientation, and minimal scar stretch-back.
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / surgery. Head and Neck Neoplasms / surgery. Humans. Male. Mohs Surgery. Reconstructive Surgical Procedures / methods. Scalp Dermatoses / surgery. Skin Neoplasms / surgery

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  • (PMID = 19467369.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Gréco M, Bessaguet-Küpfer I, Bourrigan M, Plantin P: [Diffuse milia in an infant indicative of Bazex-Dupré-Christol syndrome]. Ann Dermatol Venereol; 2006 Aug-Sep;133(8-9 Pt 1):697-9
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  • [Transliterated title] Grains de milium diffus chez un nourrisson révélateurs d'un syndrome de Bazex, Dupré et Christol.
  • Dermatological examination of the father showed atrophic cutaneous lesions with follicular punctuated depressions (like "ice-pick marks") on the back of the hands and the forearms.
  • In addition, he had a history of basal cell carcinoma with surgery before the age of 35 years.
  • Diagnosis is based on association of follicular atrophoderma, congenital hypotrichosis, hypohydrosis and early basal cell carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Epidermal Cyst / genetics. Hypotrichosis / genetics. Skin Diseases / genetics. Skin Neoplasms / genetics

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  • (PMID = 17053742.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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27. Weinstein A, Nouri K, Bassiri-Tehrani S, Flores F, Jimenez G: Muir-Torre syndrome: a case of this uncommon entity. Int J Dermatol; 2006 Mar;45(3):311-3
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  • A 69-year-old Hispanic woman presented for the evaluation of nodules on the head and back.
  • In the past, she had been treated for basal cell carcinoma (BCC) of the face; the referring physician was concerned that the new lesions might also be BCC.
  • In addition to BCC, she had been treated for breast cancer, colon cancer, and cervical cancer prior to emigrating to the USA.
  • Further details of her medical history and cancer staging were not available.
  • Her family history was significant for a sister with colon cancer and transitional cell carcinoma of the urinary bladder.
  • In addition, she had a great aunt with oral cancer and a great uncle with lung cancer.
  • On physical examination, in addition to scars from a radical mastectomy and midline abdominal laparotomy, four skin lesions were noted: two on the scalp, one on the tragus, and one on the mid-back.
  • This lesion was similar to that on the mid-back, except in size.
  • The lesion on the back measured 1.2 x 1.0 cm.
  • The lesions on the scalp and mid-back revealed lobules of sebaceous cells in the dermis with a minority of surrounding basaloid cells, consistent with a diagnosis of sebaceous adenoma (Fig. 1).
  • [MeSH-major] Breast Neoplasms / complications. Carcinoma, Basal Cell / complications. Colonic Neoplasms / complications. Skin Neoplasms / complications. Uterine Cervical Neoplasms / complications
  • [MeSH-minor] Adenoma / complications. Adenoma / genetics. Aged. Carcinoma / complications. Carcinoma / genetics. Female. Genetic Diseases, Inborn / genetics. Humans. Sebaceous Gland Neoplasms / complications. Sebaceous Gland Neoplasms / genetics. Syndrome


28. Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y: Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line. Biochem J; 2010 Jul 1;429(1):53-61
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  • [Title] Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line.
  • A novel function of COMMD1 {COMM [copper metabolism MURR1 (mouse U2af1-rs1 region 1)]-domain-containing 1}, a protein relevant to canine copper toxicosis, was examined in the mouse hepatoma cell line Hepa 1-6 with multi-disciplinary techniques consisting of molecular and cellular biological techniques, speciation and elemental imaging.
  • It is known that the liver copper transporter Atp7b (ATP-dependent copper transporter 7beta), localizes on the trans-Golgi network membrane under basal copper conditions and translocates to cytoplasmic vesicles to excrete copper when its concentration exceeds a certain threshold, with the vesicles dispersing in the periphery of the cell.
  • COMMD1-knockdown reduced the expression of Atp7b, and abolished the relocation of Atp7b back from the periphery to the trans-Golgi network membrane when the copper concentration was reduced by treatment with a Cu(I) chelator.
  • [MeSH-major] Adenosine Triphosphatases / metabolism. Carcinoma, Hepatocellular / metabolism. Cation Transport Proteins / metabolism. Liver Neoplasms / metabolism. Proteins / physiology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Animals. Cell Line, Tumor. Copper / chemistry. Copper / deficiency. Copper / metabolism. Enzyme Stability / genetics. Gene Knockdown Techniques / methods. Intracellular Fluid / chemistry. Intracellular Fluid / enzymology. Intracellular Fluid / metabolism. Mice. RNA, Small Interfering / genetics

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  • (PMID = 20433422.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Cation Transport Proteins; 0 / Commd1 protein, mouse; 0 / Proteins; 0 / RNA, Small Interfering; 789U1901C5 / Copper; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / copper-transporting ATPases
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29. Eberle FC, Schippert W, Trilling B, Röcken M, Breuninger H: Cosmetic results of histographically controlled excision of non-melanoma skin cancer in the head and neck region. J Dtsch Dermatol Ges; 2005 Feb;3(2):109-12
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  • [Title] Cosmetic results of histographically controlled excision of non-melanoma skin cancer in the head and neck region.
  • PATIENTS AND METHODS: From 1990 to 2000, we treated a total of 5,227 large basal cell carcinomas (BBC) and 1,189 squamous cell carcinomas (SCC) in the head and neck region by surgical excision in 4,239 inpatients at the Department of Dermatology, University of Tübingen.
  • RESULTS: Of the 5,565 follow-up questionnaires sent back, 4,868 contained answers regarding the cosmetic result.
  • CONCLUSION: With respect to both long term safety and cosmetic outcome, tumor surgery with 3D-histology of excisional margins has set very high quality standards in the treatment of non-melanoma skin cancer of the head and neck area.
  • [MeSH-minor] Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Germany / epidemiology. Humans. Melanoma / epidemiology. Melanoma / pathology. Melanoma / surgery. Prospective Studies. Treatment Outcome

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  • (PMID = 16351013.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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30. Papadopoulos O, Konofaos P, Medvedev V, Chrisostomidis C: Island vertical trapezius myocutaneous flap procedure under the tumescent technique. Eur Surg Res; 2007;39(2):118-21
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  • We describe the application of local anesthesia with intravenous sedation for covering a large defect of the upper back with the use of the island vertical trapezius myocutaneous flap to an 85-year-old male.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Skin Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Aged, 80 and over. Anesthesia, Local. Back / surgery. Humans. Hypnotics and Sedatives. Male

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17312372.001).
  • [ISSN] 0014-312X
  • [Journal-full-title] European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
  • [ISO-abbreviation] Eur Surg Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives
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31. Alessi SS, Sanches JA, Oliveira WR, Messina MC, Pimentel ER, Festa Neto C: Treatment of cutaneous tumors with topical 5% imiquimod cream. Clinics (Sao Paulo); 2009;64(10):961-6
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  • MATERIALS AND METHODS: Here, we present our experience in the treatment of 123 cutaneous tumors of various types, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Bowen's disease, erythroplasia of Queyrat, Paget's disease, and trichoepithelioma, with 5% imiquimod cream from 2003 to 2008 in the Cutaneous Oncology Group of the Dermatology Department of Hospital das Clinicas.
  • Patients were divided into two separate groups according to their diagnosis and comorbidities; these comorbidities included epidermodysplasia verruciformis, xeroderma pigmentosum, albinism, basal cell nevus syndrome, Brooke-Spiegler syndrome, HIV, chronic lymphocytic leukemia, B-cell lymphoma, and kidney transplantation.
  • Tumors were located mainly on the face, back, trunk, and legs.

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  • (PMID = 19841702.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
  • [Other-IDs] NLM/ PMC2763070
  • [Keywords] NOTNLM ; Basal cell carcinoma / Imiquimod / Immunomodulator / Immunotherapy / Non-melanoma skin cancer
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32. Alam M, Berg D, Bhatia A, Cohen JL, Hale EK, Herman AR, Huang CC, Jiang SI, Kimyai-Asadi A, Lee KK, Levy R, Rademaker AW, White LE, Yoo SS: Association between number of stages in Mohs micrographic surgery and surgeon-, patient-, and tumor-specific features: a cross-sectional study of practice patterns of 20 early- and mid-career Mohs surgeons. Dermatol Surg; 2010 Dec;36(12):1915-20
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  • Anatomic location was associated with the number of stages (analysis of variance, p<.001), with the greatest number of stages for nose (2.01) and ear (2.06) lesions and the fewest for neck (1.47), back and shoulder (1.47), and lower extremity (1.33) lesions.
  • Basal cell carcinomas required 1.92 stages (median 2.00), compared with 1.66 (median 1.00) for squamous cell carcinoma (p<.001).
  • [MeSH-minor] Analysis of Variance. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Clinical Competence. Cross-Sectional Studies. Female. Humans. Male. Surveys and Questionnaires. United States

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  • [Copyright] © 2010 by the American Society for Dermatologic Surgery, Inc.
  • (PMID = 21040123.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Perkins JL, Liu Y, Mitby PA, Neglia JP, Hammond S, Stovall M, Meadows AT, Hutchinson R, Dreyer ZE, Robison LL, Mertens AC: Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. J Clin Oncol; 2005 Jun 1;23(16):3733-41
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  • [Title] Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study.
  • PURPOSE: Nonmelanoma skin cancer (NMSC) has become the most common type of cancer in many populations throughout the world.
  • Because NMSCs are rarely lethal and most cancer registries do not routinely report data regarding these cancers, they have received little attention in studies evaluating long-term effects of cancer therapy.
  • This article reports on the occurrence of secondary NMSC as a long-term effect of cancer therapy in survivors of childhood cancer.
  • PATIENTS AND METHODS: The Childhood Cancer Survivor Study (CCSS) is a cohort study of 5-year survivors of childhood and adolescent cancer from 25 participating institutions in North America.
  • NMSC patients were defined by a history of basal cell or squamous cell carcinoma of the skin after primary malignancy treatment.
  • Location of NMSC included head and neck (43%), back (24%), chest (22%), abdomen and pelvis (5%), extremity (3%), and unknown (4%).
  • CONCLUSION: Long-term survivors of childhood and adolescent cancer who were treated with RT are at highest risk for developing NMSC.
  • [MeSH-major] Carcinoma, Basal Cell / mortality. Carcinoma, Squamous Cell / mortality. Skin Neoplasms / mortality. Survivors

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  • (PMID = 15923570.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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34. Caty V, Liu Y, Viau G, Bissonnette R: Multiple large surface photodynamic therapy sessions with topical methylaminolaevulinate in PTCH heterozygous mice. Br J Dermatol; 2006 Apr;154(4):740-2
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  • The PTCH gene plays a central role in the genesis of basal cell carcinoma (BCC).
  • At 28 weeks the mice were killed and the skin of the back processed for standard histopathology.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Carcinoma, Basal Cell / prevention & control. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use. Skin Neoplasms / prevention & control
  • [MeSH-minor] Animals. Female. Genetic Predisposition to Disease. Heterozygote. Mice. Mice, Transgenic. Neoplasms, Radiation-Induced / etiology. Neoplasms, Radiation-Induced / genetics. Neoplasms, Radiation-Induced / prevention & control. Receptors, Cell Surface / genetics. Ultraviolet Rays / adverse effects

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  • (PMID = 16536820.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Receptors, Cell Surface; 0 / methyl 5-aminolevulinate; 0 / patched receptors; 88755TAZ87 / Aminolevulinic Acid
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35. Bouguila J, Zairi I, Yacoub K, Ben Neji N, d'Hauthuille C, Khonsari H, Mokhtar M, Adouani A: [Columella defects: yet a challenge!]. Ann Chir Plast Esthet; 2008 Dec;53(6):504-12
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  • [Transliterated title] Les pertes de substance de la columelle : encore un défi !
  • The repair of nasal defects is thought to be the most ancient of facial reconstructive procedures, dating back to at least 3000 BC in India.
  • Columella defects may result from trauma, infections, carcinoma resection, syphilis, bilateral cleft lip, etc.
  • [MeSH-major] Carcinoma / surgery. Carcinoma, Basal Cell / surgery. Nasal Septum / surgery. Nose Deformities, Acquired / surgery. Nose Neoplasms / surgery. Rhinoplasty / methods

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  • (PMID = 18938019.001).
  • [ISSN] 1768-319X
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 41
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36. Tilleman TR, Tilleman MM, Neumann MH: Optimizing the cut in Mohs' micrographic surgery in regard to skin sparing and microscopic view: is a round incision cut necessary? Clin Exp Dermatol; 2005 Mar;30(2):116-9
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  • Mohs' micrographic surgery views are used to back up the geometric hypothesis.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Mohs Surgery / methods. Skin Neoplasms / surgery

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  • (PMID = 15725233.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Cózar MP, Ferrer-Rebolleda J, Redal MC, Moreno A, Tortajada L, Casáns I, Romero C: [Sentinel lymph node biopsy in cutaneous non-melanoma malignancies]. Rev Esp Med Nucl; 2006 Jan-Feb;25(1):10-4
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  • [Transliterated title] Biopsia selectiva de ganglio centinela en tumores cutáneos no melanoma.
  • RESULTS: Lymphoscintigraphy detected the sentinel node in 88,8 % of our studies (the SLN was not observed in a patient with a Merkel's tumour on the back).
  • [MeSH-minor] Adult. Aged. Carcinoma / diagnosis. Carcinoma / radionuclide imaging. Carcinoma / secondary. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / radionuclide imaging. Carcinoma, Basal Cell / secondary. Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / radionuclide imaging. Carcinoma, Merkel Cell / secondary. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / radionuclide imaging. Carcinoma, Squamous Cell / secondary. Child. Dermatofibrosarcoma / diagnosis. Dermatofibrosarcoma / radionuclide imaging. Dermatofibrosarcoma / secondary. False Negative Reactions. Female. Humans. Male. Middle Aged. Radiopharmaceuticals. Retrospective Studies. Technetium Tc 99m Aggregated Albumin

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  • (PMID = 16540005.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Technetium Tc 99m Aggregated Albumin; 0 / technetium Tc 99m nanocolloid
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38. Lee JS, Yoon HK, Sohn KC, Back SJ, Kee SH, Seo YJ, Park JK, Kim CD, Lee JH: Expression of N-terminal truncated desmoglein 3 (deltaNDg3) in epidermis and its role in keratinocyte differentiation. Exp Mol Med; 2009 Jan 31;41(1):42-50
The Lens. Cited by Patents in .

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  • In immunohistochemical studies of normal and pathologic tissues, H-145 antibody detected the protein in the cytoplasm of suprabasal layer cells, whereas an antibody directed against the N-terminal region of Dg3 (AF1720) reacted with a membrane protein in the basal layer.
  • In addition, deltaNDg3 transcript and protein were upregulated in psoriatic epidermis, and protein expression appeared to increase in epidermal tumors including Bowen's disease and squamous cell carcinoma.
  • Moreover, overexpression of deltaNDg3 led to increased migration and weakening of cell adhesion.
  • [MeSH-major] Cell Differentiation. Desmoglein 3 / genetics. Desmoglein 3 / metabolism. Keratinocytes / cytology
  • [MeSH-minor] Cell Adhesion. Cell Movement. Cells, Cultured. Epidermis / cytology. Gene Expression. Humans. Skin Diseases / genetics. Skin Diseases / metabolism. gamma Catenin / metabolism

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  • [Cites] Exp Dermatol. 2004 Mar;13(3):163-9 [14987256.001]
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  • (PMID = 19287199.001).
  • [ISSN] 1226-3613
  • [Journal-full-title] Experimental & molecular medicine
  • [ISO-abbreviation] Exp. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Desmoglein 3; 0 / gamma Catenin
  • [Other-IDs] NLM/ PMC2679284
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39. Watkins J: Dermatology and the community nurse: actinic (solar) keratosis. Br J Community Nurs; 2010 Jan;15(1):6, 8, 10-1
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  • They are then able to check other sun-exposed areas such as the face, ears, scalp, back and limbs to discover any other lesions or more serious problems of basal cell carcinoma, squamous cell carcinoma or malignant melanoma the would require referral, sometimes urgently, to a dermatologist for full assessment and treatment.

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  • (PMID = 20216512.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sunscreening Agents
  • [Number-of-references] 13
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40. Hunzeker CM, Soldano AC, Prystowsky S: Epidermodysplasia verruciformis. Dermatol Online J; 2008;14(5):2
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  • Further examination showed pityriasis rosea-like lesions on her neck, back, and arms and verruca plana-like lesions on the dorsa of the hands and forearms.
  • A biopsy specimen of the ulcerated nodule showed a nodular basal-cell carcinoma.
  • Two additional biopsy specimens from her forehead showed one invasive and one in-situ squamous-cell carcinoma.

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  • (PMID = 18627738.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Zarineh A, Kozovska ME, Brown WG, Elder DE, Rabkin MS: Smooth muscle hamartoma associated with a congenital pattern melanocytic nevus, a case report and review of the literature. J Cutan Pathol; 2008 Oct;35 Suppl 1:83-6
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  • The patient is a 49-year-old male with a history of a changing 'mole' on the left upper back.
  • Unlike a recently reported case of SMH combined with a melanocytic nevus and basal cell carcinoma, the current lesion did not occur in association with a Becker's nevus.

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544054.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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42. Walsh SN, Hurt MA, Santa Cruz DJ: Psoriasiform keratosis. Am J Dermatopathol; 2007 Apr;29(2):137-40
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  • Other sites included the scalp, neck, shoulders, and back.
  • The most common diagnoses, clinically, were seborrheic keratosis, followed by basal cell carcinoma, Bowen's disease, actinic (solar) keratosis, and squamous cell carcinoma, among others.

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  • (PMID = 17414434.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Wickless SC, McNulty M, Lichon VC: Focally pigmented pink plaque on the back. Concomitant melanoma in situ, basal cell carcinoma (BCC), and angioma. Arch Dermatol; 2010 Jul;146(7):789-94
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  • [Title] Focally pigmented pink plaque on the back. Concomitant melanoma in situ, basal cell carcinoma (BCC), and angioma.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Hemangioma / diagnosis. Melanoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20644044.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Akinci M, Aslan S, Markoç F, Cetin B, Cetin A: Metastatic basal cell carcinoma. Acta Chir Belg; 2008 Mar-Apr;108(2):269-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic basal cell carcinoma.
  • [MeSH-minor] Aged. Back. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / surgery. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 18557160.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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45. Rossiello L, Zalaudek I, Cabo H, Ferrara G, Casas G, Argenziano G: Dermoscopic-pathologic correlation in an unusual case of pigmented basal cell carcinoma. Dermatol Surg; 2006 Dec;32(12):1509-12
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic-pathologic correlation in an unusual case of pigmented basal cell carcinoma.
  • [MeSH-major] Back. Carcinoma, Basal Cell / pathology. Dermoscopy. Skin Neoplasms / pathology

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  • [ErratumIn] Dermatol Surg. 2012 May;38(5):823. Gabriel, Casas [corrected to Casas, Gabriel]
  • (PMID = 17199663.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Stinco G, Frattasio A, Forcione M, Quinkenstein E, Finato N, Patrone P: The appearance of inflammatory papules in the skin surrounding areas treated with imiquimod cream for basal cell carcinoma. Br J Dermatol; 2008 Feb;158(2):408-9
Hazardous Substances Data Bank. Imiquimod .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The appearance of inflammatory papules in the skin surrounding areas treated with imiquimod cream for basal cell carcinoma.
  • [MeSH-minor] Aged. Back. Carcinoma, Basal Cell / drug therapy. Humans. Male. Skin Neoplasms / drug therapy

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  • (PMID = 18028501.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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47. Kim JR, Lee NH, Kim YS, Park JH, Yun SK: Pulmonary metastasis from a giant polypoid basal cell carcinoma in the lumbosacral area. Dermatol Surg; 2010;36(1):128-32
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pulmonary metastasis from a giant polypoid basal cell carcinoma in the lumbosacral area.
  • [MeSH-major] Carcinoma, Basal Cell / secondary. Lung Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Back. Fatal Outcome. Humans. Lumbosacral Region. Male. Middle Aged. Sacrococcygeal Region

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  • (PMID = 19889160.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Levine N: Asymptomatic lesions isolated to lower back. Patient has undergone radiation therapy for tumor of kidney. Geriatrics; 2005 Aug;60(8):15
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic lesions isolated to lower back. Patient has undergone radiation therapy for tumor of kidney.
  • [MeSH-minor] Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Keratosis, Seborrheic / pathology. Lupus Erythematosus, Cutaneous / pathology. Male. Middle Aged. Tinea / pathology

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  • (PMID = 16092886.001).
  • [ISSN] 0016-867X
  • [Journal-full-title] Geriatrics
  • [ISO-abbreviation] Geriatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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