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1. Klucky B, Mueller R, Vogt I, Teurich S, Hartenstein B, Breuhahn K, Flechtenmacher C, Angel P, Hess J: Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion. Cancer Res; 2007 Sep 1;67(17):8198-206
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  • Recently, we described phorbol ester-induced expression of the brain and skin serine proteinase Bssp/kallikrein 6 (Klk6), the mouse orthologue of human KLK6, in mouse back skin and in advanced tumor stages of a well-established multistage tumor model.
  • Here, we show KLK6 up-regulation in squamous skin tumors of human patients and in tumors of other epithelial tissues.

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  • (PMID = 17804733.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin; EC 3.4.21.- / KLK6 protein, human; EC 3.4.21.- / Kallikreins; EC 3.4.24.- / Matrix Metalloproteinases
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2. Wu A, Oh S, Gharagozlou S, Vedi RN, Ericson K, Low WC, Chen W, Ohlfest JR: In vivo vaccination with tumor cell lysate plus CpG oligodeoxynucleotides eradicates murine glioblastoma. J Immunother; 2007 Nov-Dec;30(8):789-97
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  • [Title] In vivo vaccination with tumor cell lysate plus CpG oligodeoxynucleotides eradicates murine glioblastoma.
  • The typical approach has been to generate the vaccine ex vivo, by pulsing DCs with tumor lysate or peptides, then administering the DCs back into the patient.
  • Recent studies have shown that coadministration of toll-like receptor 9 agonists, CpG oligodeoxynucleotides, can promote DC vaccines to break immune tolerance to tumor antigens.
  • Subcutaneous vaccination with CpG/lysate induced a significant increase (P<0.05) in the number of total T cells and activated DCs in lymph nodes draining the vaccination site as compared to mice treated with CpG or tumor lysate alone.
  • Up to 55% of mice vaccinated with CpG/lysate were rendered tumor-free as assessed by survival and bioluminescent imaging.
  • Splenocytes taken from mice vaccinated with CpG/lysate elaborated significantly more IFN-gamma production and displayed greater tumor cell lysis activity compared with the control groups (P<0.05).
  • [MeSH-minor] Adjuvants, Immunologic / therapeutic use. Animals. CD4-Positive T-Lymphocytes / cytology. CD4-Positive T-Lymphocytes / immunology. CD8-Positive T-Lymphocytes / cytology. CD8-Positive T-Lymphocytes / immunology. Cell Count. Cell Extracts / immunology. Cell Line, Tumor. Coculture Techniques. Cytotoxicity Tests, Immunologic. Dendritic Cells / cytology. Dendritic Cells / immunology. Dendritic Cells / metabolism. Female. Interferon-gamma / metabolism. Lymph Nodes / cytology. Lymph Nodes / immunology. Mice. Mice, Inbred C57BL. Spleen / cytology. Spleen / immunology. Survival Analysis. T-Lymphocytes / cytology. T-Lymphocytes / immunology. T-Lymphocytes / metabolism. T-Lymphocytes, Cytotoxic / immunology. Treatment Outcome

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  • (PMID = 18049330.001).
  • [ISSN] 1524-9557
  • [Journal-full-title] Journal of immunotherapy (Hagerstown, Md. : 1997)
  • [ISO-abbreviation] J. Immunother.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5 P30 CA077598
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Cancer Vaccines; 0 / Cell Extracts; 0 / CpG ODN 2006; 0 / Oligodeoxyribonucleotides; 82115-62-6 / Interferon-gamma
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3. Kaku S, Tanaka T, Ohtuka T, Seki K, Sawauchi S, Numoto RT, Murakami S, Komine K, Abe T: Perisacral gastrointestinal stromal tumor with intracranial metastasis. Case report. Neurol Med Chir (Tokyo); 2006 May;46(5):254-7
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  • [Title] Perisacral gastrointestinal stromal tumor with intracranial metastasis. Case report.
  • A 68-year-old woman presented with an extremely rare intracranial metastasis from a gastrointestinal stromal tumor (GIST) manifesting as left hemiparesis 2 years after resection of a sacral tumor adjacent to the coccygeal bone.
  • Magnetic resonance imaging revealed an intracranial tumor in the right parietal lobe.
  • Craniotomy was performed to completely remove the tumor.
  • Although the tumor was located extra-axially, only internal carotid angiography showed mass staining.
  • Seven months after surgery, the tumor recurred.
  • Repeat craniotomy was performed to remove the recurrent tumor.
  • Immunohistochemical analysis showed that the tumor cells were positive for c-kit and CD34, and the tumors were identified as intracranial metastasis of GIST.
  • Following the second intracranial surgery, the patient developed severe lower back pain caused by metastatic tumor invading the lumbar spine and ureter.
  • To avoid surgical complications and to reduce tumor volume, imatinib mesylate (Gleevec) was administered.
  • The severe pain was relieved, although the tumor was not reduced.
  • In this case, the extra-axial tumor was fed only by the internal carotid artery.
  • [MeSH-major] Brain Neoplasms / secondary. Gastrointestinal Neoplasms / pathology. Gastrointestinal Stromal Tumors / secondary. Sacrum / pathology
  • [MeSH-minor] Aged. Female. Humans. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 16723820.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Tokunaga K, Sugiu K, Miyoshi Y, Mimura H, Kanazawa S, Date I: [Percutaneous vertebroplasty combined with radiofrequency ablation for a patient with a spinal metastatic tumor: case report]. No Shinkei Geka; 2005 Aug;33(8):811-5
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  • [Title] [Percutaneous vertebroplasty combined with radiofrequency ablation for a patient with a spinal metastatic tumor: case report].
  • Recent technological development has allowed expanding applications of radiofrequency ablation (RFA) for malignant tumor therapy.
  • We report a case with a spinal metastatic tumor treated with combination of percutaneous vertebroplasty (PVP) that provides pain relief and spinal stabilization and RFA.
  • A 68-year-old male who had undergone resection of left ureteric carcinoma was referred to our hospital with lower back pain due to the fifth lumbar (L5) vertebral metastatic tumor.
  • One year later, the patient was admitted again with weakness of the right knee and foot and severe pain of the back and the right lower extremity.
  • CT and MRI showed a tumor of the L5 body invading the right pedicle, the intervertebral foramen, and the retroperitoneal space.
  • Combined treatment with RFA and PVP is a feasible and promising procedure for spinal metastatic tumors.
  • [MeSH-minor] Aged. Back Pain / etiology. Bone Cements. Combined Modality Therapy. Humans. Injections, Spinal. Male. Treatment Outcome. Ureteral Neoplasms / pathology

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  • (PMID = 16095212.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bone Cements
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5. Kim B, Moon SH, Kim SY, Kim HJ, Lee HM: Delayed Spinal Epidural Hematoma after En Block Spondylectomy for Vertebral Ewing's Sarcoma. Asian Spine J; 2010 Dec;4(2):118-22
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  • Nine days after surgery, he presented with severe back pain and motor weakness of the lower extremities.
  • This case showed that extensive surgery for a malignant vertebral tumor has a potential risk of delayed epidural hematoma and acute cauda equina syndrome and this should be treated with emergency evacuation.

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  • (PMID = 21165315.001).
  • [ISSN] 1976-7846
  • [Journal-full-title] Asian spine journal
  • [ISO-abbreviation] Asian Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2996623
  • [Keywords] NOTNLM ; En block spondylectomy / Epidural hematoma / Ewing's sarcoma / Spine
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6. Li G, Barrett EJ, Barrett MO, Cao W, Liu Z: Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway. Endocrinology; 2007 Jul;148(7):3356-63
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  • [Title] Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway.
  • Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha-treated bAECs without affecting TNF-alpha-induced ERK1/2 and AMPK phosphorylation.
  • [MeSH-major] Endothelial Cells / drug effects. Insulin / pharmacology. Signal Transduction / drug effects. Tumor Necrosis Factor-alpha / pharmacology. p38 Mitogen-Activated Protein Kinases / metabolism

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  • (PMID = 17446186.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-073759; United States / NIDDK NIH HHS / DK / DK-DK057878; United States / NIDDK NIH HHS / DK / P30-DK063609
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin; 0 / Insulin Receptor Substrate Proteins; 0 / Multienzyme Complexes; 0 / Phosphoproteins; 0 / Tumor Necrosis Factor-alpha; EC 1.14.13.39 / Nitric Oxide Synthase Type III; EC 2.7.11.1 / AMP-Activated Protein Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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7. Burger M, Catto J, van Oers J, Zwarthoff E, Hamdy FC, Meuth M, Azzouri AR, Cussenot O, Wild PJ, Stoehr R, Hartmann A: [Mutation of the FGFR3 oncogene is an independent and favorable prognostic factor for tumor-specific survival in patients with urothelial carcinoma of the upper urinary tract]. Verh Dtsch Ges Pathol; 2006;90:244-52
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  • [Title] [Mutation of the FGFR3 oncogene is an independent and favorable prognostic factor for tumor-specific survival in patients with urothelial carcinoma of the upper urinary tract].
  • AIMS: Urothelial tumors of the upper urinary tract (UUTT) frequently display microsatellite Instability (MSI) and a distinct pathway of tumorigenesis resembling MMR-deficient colorectal cancers has been recognized for MSI-UUTT.
  • Neither MSI- nor FGFR3-status had any influence on subsequent bladder tumors.
  • Thus our findings might back the notion, that MSS and MSI-UUTTs stem from different oncogenic pathways and that their differing molecular character might have some relevance.
  • Further research is warranted to study the clinical behavior of these tumors and to evaluate a potential role for MS-status and FGFR3 as prognostic tools.
  • [MeSH-minor] Female. Gene Frequency. Genomic Instability. Humans. Male. Microsatellite Repeats. Neoplasm Staging. Oncogenes. Prognosis. Survivors. Treatment Outcome

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  • (PMID = 17867603.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.10.1 / FGFR3 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 3
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8. Amaia A, Pachón G, Cascante M, Creppy EE, Monge A, López de Cerain A: Selective toxicity of a quinoxaline 1,4-di-N-oxide derivative in human tumour cell lines. Arzneimittelforschung; 2005;55(3):177-82
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  • These drugs, called bioreductive agents, are activated inside the hypoxic cells to give active species that, in the presence of oxygen, are oxidised back to the non-toxic parent compound.
  • [MeSH-minor] Cell Hypoxia. Cell Line, Tumor. Cell Survival / drug effects. Dose-Response Relationship, Drug. Drug Screening Assays, Antitumor. Humans. Tumor Stem Cell Assay

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  • (PMID = 15819391.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 7-chloro-3-(((N,N-dimethylamino)propyl)amino)-2-quinoxalinecarbonitrile-1,4-di-N-oxide; 0 / Antineoplastic Agents; 0 / Quinoxalines
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9. Tada Y, Takiguchi Y, Terada J, Yoshida T, Shinozaki A, Sakao S, Kasahara Y, Kurosu K, Tanabe N, Tatsumi K, Hiroshima K, Kuriyama T: [A case of angiosarcoma of pelvis with pulmonary metastases which responded to paclitaxel]. Gan To Kagaku Ryoho; 2007 Dec;34(13):2275-7
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  • A 60-year-old man was admitted to our hospital complaining of back pain and bloody sputum.
  • Biopsy of the bone lesion established a diagnosis of angiosarcoma.
  • After eight weeks, the tumor recurred.

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  • (PMID = 18079629.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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10. Gatto B: Biologics targeted at TNF: design, production and challenges. Reumatismo; 2006 Apr-Jun;58(2):94-103
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  • Several biotech-derived drugs aimed at Tumor Necrosis Factor (TNF) have been licensed in the last years, profoundly changing the therapy of several autoimmune diseases based on inflammation, affecting the life of patients and bringing to the market attention the growth potentials of biologics directed at cytokines.
  • The proof of principles that led to the design of these compounds dates back from the nineties, when the involvement of TNF in rheumatoid arthritis was proved by the ability of specific anti-TNF proteins to modulate the inflammatory response in animal models.
  • [MeSH-major] Autoimmune Diseases / drug therapy. Biological Products / chemical synthesis. Biological Products / pharmacology. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Adalimumab. Antibodies, Monoclonal / pharmacology. Antibodies, Monoclonal, Humanized. Etanercept. Humans. Immunoglobulin G / pharmacology. Infliximab. Receptors, Tumor Necrosis Factor

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  • (PMID = 16829986.001).
  • [ISSN] 0048-7449
  • [Journal-full-title] Reumatismo
  • [ISO-abbreviation] Reumatismo
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Biological Products; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; B72HH48FLU / Infliximab; FYS6T7F842 / Adalimumab; OP401G7OJC / Etanercept
  • [Number-of-references] 56
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11. Miyake S, Kobayashi N, Murai N, Kondoh T, Kohmura E: Acquired lumbar epidermoid cyst in an adult. Neurol Med Chir (Tokyo); 2005 May;45(5):277-9
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  • A 61-year-old female complained of low back pain, and had been treated by spinal anesthetic injection more than 70 times over 14 years.
  • This case clearly demonstrates that adults can acquire epidermoid tumor which very probably has an iatrogenic origin.
  • The incidence of epidermoid tumor is low, but we should be aware of the potential adverse complications such as formation of epidermoid tumors after lumbar puncture.

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  • (PMID = 15914971.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Seifried HE, Seifried RM, Clarke JJ, Junghans TB, San RH: A compilation of two decades of mutagenicity test results with the Ames Salmonella typhimurium and L5178Y mouse lymphoma cell mutation assays. Chem Res Toxicol; 2006 May;19(5):627-44
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  • P., Rogers-Back, A.
  • [MeSH-minor] Animals. Drug-Related Side Effects and Adverse Reactions. Mice. Mutagenicity Tests. Tumor Cells, Cultured / drug effects

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  • [ErratumIn] Chem Res Toxicol. 2008 Feb;21(2):554-5
  • (PMID = 16696565.001).
  • [ISSN] 0893-228X
  • [Journal-full-title] Chemical research in toxicology
  • [ISO-abbreviation] Chem. Res. Toxicol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mutagens
  • [Number-of-references] 35
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13. Guo L, Chua J, Vijayakumar D, Lee KC, Lim K, Eng H, Ghadessy F, Coomber D, Lane DP: Detection of the 113p53 protein isoform: a p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish. Cell Cycle; 2010 May 15;9(10):1998-2007
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  • [Title] Detection of the 113p53 protein isoform: a p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish.
  • [MeSH-major] Protein Isoforms / metabolism. Tumor Suppressor Protein p53 / metabolism. Zebrafish Proteins / metabolism

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  • (PMID = 20505327.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Tumor Suppressor Protein p53; 0 / Zebrafish Proteins
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14. Okada M, Kitagawa M, Shibuya H, Kanayama K, Sato T, Yamamura H, Sakai T: Malignant peripheral nerve sheath tumor arising from the spinal canal in a cat. J Vet Med Sci; 2007 Jun;69(6):683-6
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  • [Title] Malignant peripheral nerve sheath tumor arising from the spinal canal in a cat.
  • A 10-year-old female mongrel cat with back pain was brought to the Nihon University Animal Medical Center.
  • Palpation demonstrated a mass in the back region.
  • Histopathologically, the mass was a malignant peripheral nerve sheath tumor.

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  • (PMID = 17611372.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Van Buren G 2nd, Rashid A, Yang AD, Abdalla EK, Gray MJ, Liu W, Somcio R, Fan F, Camp ER, Yao JC, Ellis LM: The development and characterization of a human midgut carcinoid cell line. Clin Cancer Res; 2007 Aug 15;13(16):4704-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Gastrointestinal neuroendocrine tumors (NET) are rare heterogeneous tumors that hypersecrete neuropeptides.
  • We describe and characterize the establishment of a human midgut carcinoid tumor cell line carcinoid tumor 2 (CNDT2).
  • EXPERIMENTAL DESIGN: Tumor cells (CNDT2) were isolated from a liver metastasis from a patient with a primary ileal carcinoid.
  • After 9 weeks in culture, the cells were plated in soft agar, and cells from a single colony were put back in culture (CNDT2.1).
  • Cells were isolated from a single resultant tumor (CNDT2.5), cultured, and characterized by electron microscopy, reverse transcription-PCR, serotonin enzyme immunoassay, Western blotting, and immunohistochemical analysis for NET markers and potential therapeutic targets.
  • RESULTS: CNDT2 cells grew in monolayers in vitro, formed colonies in soft agar, and formed tumors in mice.
  • Tumor xenografts exhibited the appearance of NETs with small "salt-and-pepper" nuclei on H&E staining and chromogranin A, synaptophysin, and CD56 on immunohistochemical staining.
  • CONCLUSION: The establishment of this human midgut carcinoid tumor cell line may serve as a useful model system for studying cell biology and novel targeted agents in preclinical models.
  • [MeSH-major] Carcinoid Tumor / pathology. Ileal Neoplasms / pathology
  • [MeSH-minor] Animals. Cell Line, Tumor. Chromosome Aberrations. Female. Humans. Male. Mice. Mice, Nude. Middle Aged. Neoplasm Transplantation. Receptors, Vascular Endothelial Growth Factor / analysis. Serotonin / biosynthesis. Transplantation, Heterologous. Vascular Endothelial Growth Factor A / analysis


17. Handa H, Irisawa H, Komatsumoto S, Matsushima T, Tsukamoto N, Nojima Y, Murakami H: [Plasmacytoma with multiple hypervascular lesions revealed by angiography in a patient with multiple myeloma]. Rinsho Ketsueki; 2006 Jun;47(6):521-5
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  • A 68-year-old woman suffering from a left iliac tumor and severe back pain was admitted to another hospital in May 1999.
  • The bone X-ray, CT scan and MRI demonstrated a 7 cm x 5 cm left iliac tumor with osteolysis and she was transferred to our hospital.
  • The tumor was resected and diagnosed as a plasmacytoma.

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  • (PMID = 16862980.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Nitrosourea Compounds; 9PHQ9Y1OLM / Prednisolone; Q41OR9510P / Melphalan; RSA8KO39WH / Vindesine; VB0R961HZT / Prednisone; AP protocol 2; MCNU-VMP protocol
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18. Nicolae C, Olsen BR: Unexpected matrix diseases and novel therapeutic strategies. Cell Tissue Res; 2010 Jan;339(1):155-65
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  • Within the framework of a broad definition of the extracellular matrix (ECM), this review discusses three genetic disorders in which major pathogenetic features have been traced back to alterations in the levels/activities of matrix components.
  • The primary defect involves an intracellular signaling molecule, but a major pathogenetic component and therapeutic target of the disease is the extracellular cytokine tumor necrosis factor alpha.
  • The second disorder, Knobloch syndrome, is caused by recessive mutations in collagen XVIII.
  • The third disorder, infantile hemangioma, is a common tumor of capillary endothelial cells in infancy.
  • The tumor appears within a few days/weeks after birth, grows rapidly over several months, and regresses over several years.
  • [MeSH-minor] Animals. Child. Child, Preschool. Collagen / genetics. Collagen / metabolism. Humans. Infant, Newborn. Inflammation / genetics. Inflammation / metabolism. Inflammation / pathology. Inflammation / therapy. Tumor Necrosis Factor-alpha / genetics. Tumor Necrosis Factor-alpha / metabolism. Vascular Endothelial Growth Factor Receptor-1 / genetics. Vascular Endothelial Growth Factor Receptor-1 / metabolism. Vascular Endothelial Growth Factor Receptor-2 / genetics. Vascular Endothelial Growth Factor Receptor-2 / metabolism

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  • (PMID = 19813027.001).
  • [ISSN] 1432-0878
  • [Journal-full-title] Cell and tissue research
  • [ISO-abbreviation] Cell Tissue Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / COL28A1 protein, human; 0 / Tumor Necrosis Factor-alpha; 9007-34-5 / Collagen; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Number-of-references] 83
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19. Schirmer CM, Malek AM, Kwan ES, Hoit DA, Weller SJ: Preoperative embolization of hypervascular spinal metastases using percutaneous direct injection with n-butyl cyanoacrylate: technical case report. Neurosurgery; 2006 Aug;59(2):E431-2; author reply E431-2
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  • OBJECTIVE: Intraoperative blood loss constitutes a major cause of perioperative morbidity in surgical decompression and reconstruction of highly vascular spinal metastatic tumors.
  • Surgical resection was performed with lower than expected blood loss and with a subjective improvement in tumor tissue handling and dissection.
  • CONCLUSION: The extent of tumor devascularization can be improved by supplementing transarterial embolization with NBCA direct injection to decrease operative blood loss and increase the safety of surgical resection and stabilization of highly vascular spinal metastases.
  • [MeSH-minor] Administration, Cutaneous. Aged. Back Pain / etiology. Back Pain / physiopathology. Back Pain / surgery. Decompression, Surgical / instrumentation. Decompression, Surgical / methods. Enbucrilate. Female. Humans. Male. Middle Aged. Neck Pain / etiology. Neck Pain / physiopathology. Neck Pain / surgery. Postoperative Hemorrhage / etiology. Postoperative Hemorrhage / physiopathology. Postoperative Hemorrhage / prevention & control. Preoperative Care / instrumentation. Preoperative Care / methods. Reconstructive Surgical Procedures / instrumentation. Reconstructive Surgical Procedures / methods. Recurrence. Reoperation. Spinal Cord Compression / etiology. Spinal Cord Compression / physiopathology. Spinal Cord Compression / surgery. Spine / blood supply. Spine / pathology. Spine / surgery. Treatment Outcome

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  • (PMID = 16883157.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyanoacrylates; F8CEP82QNP / Enbucrilate
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20. Satter EK: Solitary superficial angiomyxoma: an infrequent but distinct soft tissue tumor. J Cutan Pathol; 2009 Oct;36 Suppl 1:56-9
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  • [Title] Solitary superficial angiomyxoma: an infrequent but distinct soft tissue tumor.
  • Superficial angiomyxoma (SA) is a distinct soft tissue tumor characterized by a circumscribed collection of spindled and stellate fibroblasts that are admixed with thin-walled blood vessels and embedded in a mucinous stroma.
  • Because of its relative infrequent occurrence, the purpose of this article was to present a classical example of an isolated superficial angiomyxoma and discuss the differential diagnosis.
  • [MeSH-major] Back / pathology. Myxoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 19187115.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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21. Rodriguez FJ, Scheithauer BW, Abell-Aleff PC, Elamin E, Erlandson RA: Low grade malignant peripheral nerve sheath tumor with smooth muscle differentiation. Acta Neuropathol; 2007 Jun;113(6):705-9
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  • [Title] Low grade malignant peripheral nerve sheath tumor with smooth muscle differentiation.
  • Malignant peripheral nerve sheath tumors are usually Schwann cell derived.
  • Incisional biopsy of the slowly growing mass demonstrated a low-grade malignant peripheral nerve sheath tumor with strong S-100 protein immunoexpression as well as focal smooth muscle actin staining in atypical neoplastic cells.
  • Smooth muscle should be added to the spectrum of differentiation exhibited by malignant peripheral nerve sheath tumors.
  • Its recognition requires exclusion of the alternative diagnosis of leiomyosarcoma.
  • [MeSH-minor] Biopsy. Bone Neoplasms / secondary. Cell Differentiation / physiology. Fatal Outcome. Forearm / pathology. Humans. Immunohistochemistry. Low Back Pain / etiology. Male. Microscopy, Electron. Middle Aged. Paraffin Embedding. S100 Proteins / metabolism. Skin Neoplasms / pathology

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  • (PMID = 17119986.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins
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22. Grossman AB, Kelly P, Rockall A, Bhattacharya S, McNicol A, Barwick T: Cushing's syndrome caused by an occult source: difficulties in diagnosis and management. Nat Clin Pract Endocrinol Metab; 2006 Nov;2(11):642-7
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  • [Title] Cushing's syndrome caused by an occult source: difficulties in diagnosis and management.
  • BACKGROUND: A 24-year-old woman presented with a 12.5 kg weight gain over 6 months (mostly abdominal), hirsutism, acne, ankle edema, polydipsia, nocturia, back pain, pigmentation, poor libido and lightened menses to our hospital in May 1986.
  • INVESTIGATIONS: Serum potassium and bicarbonate, circadian rhythm of cortisol, low-dose and high-dose dexamethasone suppression tests, plasma adrenocorticotropic hormone (ACTH), corticotropin releasing-hormone stimulation test, CT scan of the pituitary, plain chest radiology, CT scan of the chest and abdomen, trans-sphenoidal pituitary biopsy and histology, CT scan and MRI of the thorax, MRI of the pituitary, octreotide scintigraphy, gastroscopy, colonoscopy, gut peptides, tumor markers, urine 5-hydroxyl-indole-acetic acid, resection, histology, immunocytochemistry and in situ hybridization.
  • DIAGNOSIS: Occult ectopic ACTH syndrome from a presumed appendiceal neuroendocrine tumor.
  • The tumor was only identified some 20 years from initial presentation.
  • [MeSH-major] ACTH Syndrome, Ectopic / complications. ACTH Syndrome, Ectopic / diagnosis. Cushing Syndrome / diagnosis. Cushing Syndrome / etiology
  • [MeSH-minor] Adrenalectomy. Adult. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / secretion. Appendiceal Neoplasms / surgery. Appendiceal Neoplasms / ultrasonography. Carcinoid Tumor / diagnosis. Carcinoid Tumor / secretion. Carcinoid Tumor / surgery. Carcinoid Tumor / ultrasonography. Female. Humans. Long-Term Care

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  • [ErratumIn] Nat Clin Pract Endocrinol Metab. 2007 Jan;3(1):69. Balwick, Tara [corrected to Barwick, Tara]
  • (PMID = 17082811.001).
  • [ISSN] 1745-8366
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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23. Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA: Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. Clin Cancer Res; 2005 Apr 15;11(8):3055-64
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  • NQO1 reduces beta-lapachone to an unstable hydroquinone that rapidly undergoes a two-step oxidation back to the parent compound, perpetuating a futile redox cycle.
  • The use of beta-lapachone mono(arylimino) prodrug derivatives, or more specifically a derivative converted in a tumor-specific manner (i.e., in the acidic local environment of the tumor tissue), should reduce normal tissue toxicity while eliciting tumor-selective cell killing by NQO1 bioactivation.
  • [MeSH-minor] Cell Division / drug effects. Cell Line, Tumor. Cell Survival / drug effects. Chromatography, High Pressure Liquid. Dose-Response Relationship, Drug. Humans. Magnetic Resonance Spectroscopy. Neoplasms / drug therapy. Neoplasms / enzymology. Neoplasms / pathology. Spectrometry, Mass, Electrospray Ionization. Spectrophotometry, Ultraviolet. Structure-Activity Relationship

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  • (PMID = 15837761.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA142543; United States / NCI NIH HHS / CA / R01 CA102792; United States / NCI NIH HHS / CA / 5T32 CA59366; United States / NCI NIH HHS / CA / R01 CA-92250
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Naphthoquinones; 0 / Prodrugs; 4707-32-8 / beta-lapachone; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human
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24. Lee JS, Suh KT: Intradural disc herniation at L5-S1 mimicking an intradural extramedullary spinal tumor: a case report. J Korean Med Sci; 2006 Aug;21(4):778-80
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  • [Title] Intradural disc herniation at L5-S1 mimicking an intradural extramedullary spinal tumor: a case report.
  • The patient presented with pain in the lower back and both lower legs for 4 months and a sudden exacerbation of the symptoms for 3 days.
  • Intradural lumbar disc herniation must be considered in the differential diagnosis of mass lesions in the spinal canal.
  • Contrast-enhanced MRI scans are useful to differentiate a herniated disc from a disc space infection or tumor.
  • [MeSH-major] Intervertebral Disc Displacement / diagnosis. Lumbar Vertebrae. Sacrum. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Dura Mater. Humans. Laminectomy. Male. Middle Aged

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  • [Cites] Spinal Cord. 2001 Oct;39(10):545-8 [11641800.001]
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  • (PMID = 16891832.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2729910
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25. Yoon SH, Kim KJ, Chung SK, Kim HJ, Choe G, Chung SB, Jin YJ: Inflammatory myofibroblastic tumor in the intradural extramedullary space of the lumbar spine with spondylolisthesis: case report and review of the literature. Eur Spine J; 2010 Jul;19 Suppl 2:S153-7
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  • [Title] Inflammatory myofibroblastic tumor in the intradural extramedullary space of the lumbar spine with spondylolisthesis: case report and review of the literature.
  • An inflammatory myofibroblastic tumor (IMT) is a rare disease entity reported to arise in various organs but still thought to be a neoplastic or reactive inflammatory condition controversially.
  • [MeSH-minor] Back Pain / etiology. Diagnosis, Differential. Female. Humans. Inflammation / etiology. Inflammation / pathology. Inflammation / physiopathology. Middle Aged. Spinal Canal / pathology. Spinal Canal / physiopathology. Treatment Outcome

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  • (PMID = 19941012.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899620
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26. Yamauchi M, Okamoto Y, Doi M, Shinozaki K: [mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report]. Gan To Kagaku Ryoho; 2010 Nov;37(11):2209-11
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  • A 66-year-old man was referred to our hospital because of a two-week history off ever and low back pain.
  • Systemic chemotherapy (mFOLFOX6) was started, then remission of DIC and shrinkage of the tumor were observed.

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  • (PMID = 21084829.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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27. Kuscu E, Oktem M, Eroglu D, Haberal A, Bilezikci B, Demirhan B: Pelvic retroperitoneal paraganglioma mimicking an ovarian mass. Eur J Gynaecol Oncol; 2005;26(2):219-20
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  • She complained of headache and right-sided back pain.
  • Tumor markers were in the normal range.
  • The mass was completely removed and and the histopathologic diagnosis was paraganglioma.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Paraganglioma / diagnosis. Retroperitoneal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Pelvis. Ureteral Obstruction / etiology

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  • (PMID = 15857036.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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28. Alias LM, Manoharan S, Vellaichamy L, Balakrishnan S, Ramachandran CR: Protective effect of ferulic acid on 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesis in Swiss albino mice. Exp Toxicol Pathol; 2009 May;61(3):205-14
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  • Skin squamous cell carcinoma was induced in the shaved back of mice, by painting with DMBA (25 microg in 0.1 mL(-1) acetone) twice weekly for 8 weeks.
  • We have observed 100% tumor formation in the 15th week of experimental period in mice treated with DMBA alone.
  • Marked alterations in the status of phase I and phase II detoxication agents, lipid peroxidaton byproducts and antioxidants were observed in tumor bearing mice.
  • Oral administration of ferulic acid completely prevented the formation of skin tumors, whereas topically applied ferulic acid did not show significant chemopreventive activity during DMBA-induced mouse skin carcinogenesis.

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  • (PMID = 18845425.001).
  • [ISSN] 1618-1433
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antioxidants; 0 / Carcinogens; 0 / Coumaric Acids; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; AVM951ZWST / ferulic acid
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29. Costantini M, Morasso G, Montella M, Borgia P, Cecioni R, Beccaro M, Sguazzotti E, Bruzzi P, ISDOC Study Group: Diagnosis and prognosis disclosure among cancer patients. Results from an Italian mortality follow-back survey. Ann Oncol; 2006 May;17(5):853-9
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  • [Title] Diagnosis and prognosis disclosure among cancer patients. Results from an Italian mortality follow-back survey.
  • This study estimates the proportion of Italian who died of cancer who had received information about diagnosis and prognosis, and explores the variables associated with disclosure.
  • MATERIALS AND METHODS: This is a mortality follow-back survey of 1271 non-professional caregivers of Italians who died of cancer in 2002, representative of the approximate 160 000 Italian annual cancer deaths.
  • Caregivers were interviewed after the patient's death about the process of diagnosis and prognosis disclosure.
  • RESULTS: It was estimated that 37% of people who died of cancer had received information about diagnosis and 13% about poor prognosis.
  • A consistent proportion, although non-informed, knew the diagnosis (29%) and the poor prognosis (50%).
  • The probability to be informed was higher for patients living in the north of Italy, young, well educated, with longer survival, and with breast or head and neck tumor.

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  • (PMID = 16551764.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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30. Rosenthal DT, Iyer H, Escudero S, Ventura AC, Arruda EM, Garikipati K, Merajver SD: From in vitro to in silico and back again: using biological and mathematical synergy to decipher breast cancer cell motility. Conf Proc IEEE Eng Med Biol Soc; 2010;2010:3261-4
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  • [Title] From in vitro to in silico and back again: using biological and mathematical synergy to decipher breast cancer cell motility.
  • [MeSH-minor] Cell Line, Tumor. Cell Movement. Computer Simulation. Humans. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology

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  • (PMID = 21096609.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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31. Shan T, Wu T, Reng Y, Wang Y: Breed difference and regulation of the porcine adipose triglyceride lipase and hormone sensitive lipase by TNFalpha. Anim Genet; 2009 Dec;40(6):863-70
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  • Compared with Landrace pigs, the body weight (BW) of Jinhua pigs was lower (P < 0.01), while intramuscular fat content (in the longissimus dorsi muscle), as well as the back fat thickness and body fat content were higher (P < 0.01).
  • [MeSH-minor] Adipocytes / metabolism. Animals. Male. Species Specificity. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 19496768.001).
  • [ISSN] 1365-2052
  • [Journal-full-title] Animal genetics
  • [ISO-abbreviation] Anim. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; EC 3.1.1.13 / Sterol Esterase; EC 3.1.1.3 / Lipase
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32. Er U, Yigitkanli K, Simsek S, Adabag A, Bavbek M: Spinal intradural extramedullary cavernous angioma: case report and review of the literature. Spinal Cord; 2007 Sep;45(9):632-6
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  • METHOD: A 67-year-old man presented with a 4-month history of back pain and sciatica and a 4-week history of progressive lower extremity paresthesia, difficulty walking, and loss of bladder and bowel sphincter control.
  • T12 laminectomy and total tumor removal were performed without additional neurological deficit.
  • Pathological examination confirmed the diagnosis of a CA.
  • Typically, they present with low back pain and sciatica, neurological deficits, or as a subarachnoid hemorrhage.
  • These lesions have characteristic features on MRI and should be considered in the differential diagnosis of intradural spinal lesions.
  • Following a thorough literature review of reported cases, the authors propose that for patients presenting with severe preoperative neurological signs, immediate microsurgical tumor excision or decompression increases the chance of neurological improvement.
  • [MeSH-major] Hemangioma, Cavernous, Central Nervous System / diagnosis. Hemangioma, Cavernous, Central Nervous System / surgery. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery

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  • (PMID = 17091120.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 25
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33. Ecker RD, Endo T, Wetjen NM, Krauss WE: Diagnosis and treatment of vertebral column metastases. Mayo Clin Proc; 2005 Sep;80(9):1177-86
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  • [Title] Diagnosis and treatment of vertebral column metastases.
  • Patients with metastatic spinal tumors may present with pain, neurologic deficit, or both.
  • Some tumors are asymptomatic and are detected during screening examinations.
  • However, diversity of patient condition, tumor pathology, and anatomical extent of disease complicate broad generalizations for treatment.
  • Surgery is reserved for neurologic compromise, radiation failure, spinal instability, or uncertain diagnosis.
  • [MeSH-major] Spinal Neoplasms / diagnosis. Spinal Neoplasms / therapy
  • [MeSH-minor] Back Pain / etiology. Diphosphonates / therapeutic use. Glucocorticoids / therapeutic use. Humans. Orthopedic Procedures / methods. Radiculopathy / etiology

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  • (PMID = 16178498.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Glucocorticoids
  • [Number-of-references] 93
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34. Wu Y, Tang Z, Fang H, Gao S, Chen J, Wang Y, Yan H: High operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. J Surg Oncol; 2006 Oct 1;94(5):392-5
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  • One-half of the 16 patients had tumors located in the pancreatic head.
  • RESULTS: Six of twelve patients with back pain got pain relief postoperatively.
  • In the four death cases, tumors were all located in the pancreatic head; three patients with tumor close to portal vein died suddenly of massive gastrointestinal hemorrhage on the 4th, 30th, 40th postoperative day respectively and a 79-year-old patient died of acute renal failure on the 2nd postoperative day.
  • [MeSH-minor] Acute Kidney Injury / etiology. Adult. Aged. Aged, 80 and over. Back Pain / etiology. Female. Gastrointestinal Hemorrhage / etiology. Humans. Male. Middle Aged. Pancreatic Fistula / etiology. Risk


35. Domanski HA: FNA diagnosis of dermatofibrosarcoma protuberans. Diagn Cytopathol; 2005 May;32(5):299-302
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  • [Title] FNA diagnosis of dermatofibrosarcoma protuberans.
  • The tumors developed in the skin and subcutaneous tissue of the back in both patients.
  • Both tumors were diagnosed correctly when FNA was complemented by ancillary studies (immunostaining) and clinical data.
  • FNA features alone are not sufficiently characteristic to permit a confident diagnosis of DFSP.
  • Correct diagnosis requires an awareness of the clinical history and the use of ancillary studies.
  • [MeSH-minor] Adult. Back. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15830369.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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36. Jonsdottir AB, Dirks RW, Vrolijk J, Ogmundsdottir HM, Tanke HJ, Eyfjörd JE, Szuhai K: Centriole movements in mammalian epithelial cells during cytokinesis. BMC Cell Biol; 2010;11:34
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  • It has been postulated that termination of cytokinesis (abscission) depends on the migration of a centriole to the intercellular bridge and then back to the cell center.
  • To investigate the involvement of centrioles in cytokinesis, we monitored the movements of centrioles in three mammalian epithelial cell lines, HeLa, MCF 10A, and the p53-deficient mouse mammary tumor cell line KP-7.7, by time-lapse imaging.

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  • (PMID = 20492670.001).
  • [ISSN] 1471-2121
  • [Journal-full-title] BMC cell biology
  • [ISO-abbreviation] BMC Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Calcium-Binding Proteins; 0 / Chromosomal Proteins, Non-Histone; 0 / Tubulin; 118216-31-2 / caltractin
  • [Other-IDs] NLM/ PMC2893098
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37. Chan EL, Peace BE, Collins MH, Toney-Earley K, Waltz SE: Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin carcinogenesis. Oncogene; 2005 Jan 13;24(3):479-88
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  • The mice were treated with 2.5 microg of 12-O-tetradecanoylphorbol-13-acetate applied weekly to the shaved back of 36 control (TK(+/+) Tg.AC(+/-)) and 35 experimental (TK(-/-) Tg.AC(+/-)) mice.
  • The papilloma-bearing mice were monitored for the occurrence of malignant skin tumors and other malignant tumor types for a period of 48 weeks.
  • Loss of Ron receptor signaling significantly reduced the percent of papillomas that underwent malignant conversion as well as the number of mice developing other malignant tumor types.

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  • (PMID = 15531916.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD036888-05; United States / NICHD NIH HHS / HD / R01 HD036888; United States / NCI NIH HHS / CA / CA100002-02; United States / NICHD NIH HHS / HD / T32 HD43005-01; United States / NICHD NIH HHS / HD / R01 HD036888-04; United States / NCI NIH HHS / CA / CA100002-03; United States / NICHD NIH HHS / HD / HD036888-04; United States / NCI NIH HHS / CA / CA100002-01A1; United States / NICHD NIH HHS / HD / T32 HD043005; United States / NCI NIH HHS / CA / R01 CA100002-01A1; United States / NICHD NIH HHS / HD / HD036888-05; United States / NCI NIH HHS / CA / R01 CA100002-03; United States / NCI NIH HHS / CA / R01 CA100002; United States / NICHD NIH HHS / HD / HD-36888; United States / NCI NIH HHS / CA / R01 CA100002-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / RON protein; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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38. Myers MD, Dragone LL, Weiss A: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol; 2005 Jul 18;170(2):285-94
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  • Failure to degrade TCRzeta leads to an increased pool of fully assembled TCR-CD3 complexes that are capable of recycling back to the cell surface.
  • [MeSH-minor] Animals. Cell Line, Tumor. Down-Regulation. Humans. Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / metabolism. Mice. Mice, Inbred C57BL. Mice, Knockout. Phosphorylation. Protein Binding. Protein-Tyrosine Kinases / metabolism. Signal Transduction. ZAP-70 Protein-Tyrosine Kinase. src Homology Domains

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  • (PMID = 16027224.001).
  • [ISSN] 0021-9525
  • [Journal-full-title] The Journal of cell biology
  • [ISO-abbreviation] J. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Receptor-CD3 Complex, Antigen, T-Cell; 0 / Receptors, Antigen, T-Cell; 0 / Sla protein, mouse; 0 / antigen T cell receptor, zeta chain; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Lymphocyte Specific Protein Tyrosine Kinase p56(lck); EC 2.7.10.2 / Proto-Oncogene Proteins pp60(c-src); EC 2.7.10.2 / ZAP-70 Protein-Tyrosine Kinase; EC 2.7.10.2 / ZAP70 protein, human; EC 2.7.10.2 / Zap70 protein, mouse
  • [Other-IDs] NLM/ PMC2171412
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39. Sharma MC, Sarkar C, Jain D, Suri V, Garg A, Vaishya S: Uterus-like mass of müllerian origin in the lumbosacral region causing cord tethering. Report of two cases. J Neurosurg Spine; 2007 Jan;6(1):73-6
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  • In the second case a 24-year-old woman presented with low-back pain and a conus medullaris lesion, which was a cause of the TCS.
  • [MeSH-major] Lumbosacral Region / pathology. Mixed Tumor, Mullerian / pathology. Neural Tube Defects / complications. Neural Tube Defects / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lipoma / complications. Lipoma / pathology. Lipoma / surgery. Meningomyelocele / complications. Meningomyelocele / pathology. Meningomyelocele / surgery. Skin Neoplasms / complications. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Spinal Dysraphism / complications. Spinal Dysraphism / pathology. Spinal Dysraphism / surgery

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  • (PMID = 17233296.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Zhou B, Shao W, Wang G: The Application of Multi-look in UWB Microwave Imaging for Early Breast Cancer Detection Using Hemispherical Breast Model. Conf Proc IEEE Eng Med Biol Soc; 2005;2:1552-5
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  • In UWB microwave imaging for early breast cancer detection, energy allocation to each tumor may be unequally when using single-look method, thus some of the targets may not be detected when multi-tumors exist.
  • In this paper, we put forward a multi-look method: the source was set at eight difference places and eight groups of back-scattered signals were achieved by receiving antennas, the signals of each group were processed and results were added together.
  • Theoretical analysis and numerical simulation show that multi-look method can not only reduce the clutters in imaging results but also detect all tumors more efficiently, and it is better than single-look method.

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  • (PMID = 17282499.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Nadkarni TD, Menon RK, Desai KI, Goel A: Hemangioblastoma of the filum terminale. J Clin Neurosci; 2006 Feb;13(2):285-8
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  • Investigations revealed a vascular intradural cauda equina-conus tumor.
  • There were multiple dilated and tortuous veins draining from both poles of the tumor.
  • Digital subtraction spinal angiogram showed the tumor to be supplied mainly by the radiculo-medullary artery from first lumbar artery and dural branches of the second and third lumbar arteries.
  • At surgery, after pre-operative embolization, a well-defined tumor with an orange hue and fleshy consistency was encountered arising from the filum terminale.
  • The tumor was excised en bloc.
  • A sporadic hemangioblastoma arising from the filum terminale should be considered as a rare cause of back pain and sciatica.
  • Total excision of the tumor offers cure.
  • [MeSH-minor] Angiography. Humans. Low Back Pain / etiology. Magnetic Resonance Imaging. Male. Middle Aged. Muscle Spasticity / etiology. Neurosurgical Procedures. Paresthesia / etiology. Sciatica / etiology. Spinal Cord / pathology. Urinary Retention / etiology

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  • (PMID = 16459083.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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42. Mas AE, Petitbarat M, Dubanchet S, Fay S, Ledée N, Chaouat G: Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAK. Am J Reprod Immunol; 2008 Apr;59(4):323-38
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  • PROBLEM: An important subset of implantation defects/early abortion seems to be linked with a deregulation of the interleukin (IL)-12/IL-15/IL-18 system as well as tumor necrosis factor (TNF)- and natural killer (NK)-controlled/mediated networks at the decidual placental interface, both in case of deficient or excess expression.
  • METHOD OF STUDY: We first used Swiss mice to verify the presence in the murine reproductive tract of 'new members' of the IL-12 family of cytokines, IL-23 and IL-27, as well as of tumor necrosis factor-like WEAK inducer of apoptosis (TWEAK), described as acting with TNF as Yin and Yang of innate immunity in murine placenta/ decidua at days 0-12.5.
  • For RT-PCR, IL-23 expression peaked at day 9.5 in the non-aborting mating combination, a peak absent in the aborting one, and thus difficult to explain except by invoking a feed back on EB13 (Epstein-Barr virus-induced gene 3 cytokine).
  • [MeSH-major] Embryo Implantation / immunology. Interleukin-23 / analysis. Interleukin-23 / immunology. Interleukins / analysis. Interleukins / immunology. Tumor Necrosis Factors / analysis. Tumor Necrosis Factors / immunology

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  • (PMID = 18336386.001).
  • [ISSN] 1046-7408
  • [Journal-full-title] American journal of reproductive immunology (New York, N.Y. : 1989)
  • [ISO-abbreviation] Am. J. Reprod. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Il27 protein, mouse; 0 / Interleukin-23; 0 / Interleukins; 0 / Tnfsf12 protein, mouse; 0 / Tumor Necrosis Factors
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43. Cifuentes M, Calleja F, Hola J, Daviú A, Jara D, Vallejos H: [Renal angiomyolipoma rupture as a cause of lumbar pain: report of one case]. Rev Med Chil; 2008 Aug;136(8):1031-3
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  • [Transliterated title] Angiomiolipoma renal complicado como causa de dolor lumbar: Caso clínico.
  • Renal angiomyolipoma is a benign tumor formed by smooth muscle, adipose tissue and blood vessels.
  • It is commonly found incidentally and its clinical manifestations are pain and abdominal mass or spontaneous tumor rupture with retroperitoneal bleeding.
  • [MeSH-major] Angiomyolipoma / complications. Kidney Neoplasms / complications. Low Back Pain / etiology

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  • (PMID = 18949188.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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44. Balamurugan E, Reddy BV, Menon VP: Antitumor and antioxidant role of Chrysaora quinquecirrha (sea nettle) nematocyst venom peptide against Ehrlich ascites carcinoma in Swiss Albino mice. Mol Cell Biochem; 2010 May;338(1-2):69-76
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  • This investigation aims to evaluate the antitumor and antioxidant potential of Chrysaora quinquecirrha (sea nettle) nematocyst venom on Ehrlich ascites carcinoma (EAC) tumor model.
  • Tumor was induced in mice by intraperitoneal injection of EAC cells.
  • The SNV peptide brought back the altered levels of the hematological and antioxidant parameters in a dose dependent manner in EAC-bearing mice.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Antioxidants / therapeutic use. Carcinoma, Ehrlich Tumor / drug therapy. Peptides / therapeutic use. Sea Nettle, East Coast / chemistry. Venoms
  • [MeSH-minor] Animals. Body Weight. Dose-Response Relationship, Drug. Glutathione / metabolism. Male. Mice. Neoplasm Transplantation. Survival Rate. Thiobarbituric Acid Reactive Substances / metabolism

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  • (PMID = 20012161.001).
  • [ISSN] 1573-4919
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antioxidants; 0 / Peptides; 0 / Thiobarbituric Acid Reactive Substances; 0 / Venoms; GAN16C9B8O / Glutathione
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45. Northey JJ, Chmielecki J, Ngan E, Russo C, Annis MG, Muller WJ, Siegel PM: Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion. Mol Cell Biol; 2008 May;28(10):3162-76
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  • We demonstrate that TGF-beta induces the migration and invasion of mammary tumor explants expressing an activated Neu/ErbB-2 receptor, which requires signaling from autophosphorylation sites located in the C terminus.
  • A systematic analysis of mammary tumor explants expressing Neu/ErbB-2 add-back receptors that couple to distinct signaling molecules has mapped the synergistic effect of TGF-beta-induced motility and invasion to signals emanating from tyrosine residues 1226/1227 and 1253 of Neu/ErbB-2.
  • The reduction of ShcA expression rendered cells expressing activated Neu/ErbB-2, or add-back receptors signaling specifically through tyrosines 1226/1227 or 1253, unresponsive to TGF-beta-induced motility and invasion.
  • [MeSH-minor] Animals. Cell Movement / drug effects. Female. Focal Adhesions. Gene Expression. Lung Neoplasms / secondary. Mice. Mice, Nude. Neoplasm Invasiveness. Phosphotyrosine / metabolism. Point Mutation. RNA, Small Interfering / genetics. Shc Signaling Adaptor Proteins. Signal Transduction. Transfection


46. Casimiro S, Guise TA, Chirgwin J: The critical role of the bone microenvironment in cancer metastases. Mol Cell Endocrinol; 2009 Oct 30;310(1-2):71-81
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  • Tumor and bone interact in a vicious cycle, where tumor-secreted factors stimulate bone cells, which in turn release growth factors and cytokines that act back on the tumor cells.
  • Therapeutic strategies can be oriented to inhibit bone cells (osteoclasts and osteoblasts) or tumor responses to factors enriched in the bone microenvironment.
  • Many publications, especially from pre-clinical animal models, show that this approach, especially combination treatments, can reduce tumor burden and tumor-derived bone lesions.
  • This supports a novel paradigm: tumor growth can be effectively inhibited by targeting the bone and its microenvironment rather than the tumor itself alone.
  • [MeSH-major] Bone and Bones / metabolism. Neoplasm Metastasis / pathology

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  • (PMID = 19616059.001).
  • [ISSN] 1872-8057
  • [Journal-full-title] Molecular and cellular endocrinology
  • [ISO-abbreviation] Mol. Cell. Endocrinol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA40035; United States / NCI NIH HHS / CA / CA69158; United States / NIDDK NIH HHS / DK / DK065837
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] Ireland
  • [Number-of-references] 90
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47. Love RR, Uy GB: Surgical oophorectomy for breast cancer: back to the future. Future Oncol; 2008 Dec;4(6):785-92
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  • [Title] Surgical oophorectomy for breast cancer: back to the future.
  • Greater understanding of the critical variables in pathology procedures for breast tumor tissue hormonal receptor testing is leading to better definitions of the specific patients for whom hormonal therapies are indicated.

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  • (PMID = 19086845.001).
  • [ISSN] 1744-8301
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 0 / Receptors, Estrogen; 094ZI81Y45 / Tamoxifen
  • [Number-of-references] 44
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48. Kim KB, Yang JY, Kwack SJ, Park KL, Kim HS, Ryu DH, Kim YJ, Hwang GS, Lee BM: Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model. J Toxicol Environ Health A; 2010;73(21-22):1420-30
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  • A human gastric adenocarcinoma cell line (1 × 10(7) cells/ml) was grafted onto the skin of the back of intact male BALB/c-nu/nu mice.
  • After the xenografted tumors developed, urine was collected and analyzed for endogenous metabolites.
  • Global profiling combined with principal components analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and orthogonal projections to latent squares-discriminant analysis (OPLS-DA) showed distinct separation of clusters between control and tumor-bearing mice.
  • The levels of TMAO (0.41-fold) and hippurate (0.26-fold) in tumor-bearing mice were significantly decreased, whereas the levels of 3-indoxylsulfate (3.39-fold), 2-oxoglutarate (2.32-fold), and citrate (1.9-fold) were significantly increased in urine samples of tumor-bearing mice.
  • [MeSH-major] Adenocarcinoma / urine. Biomarkers, Tumor / urine. Metabolomics / methods. Stomach Neoplasms / urine
  • [MeSH-minor] Animals. Cell Line, Tumor. Citric Acid / urine. Discriminant Analysis. Disease Models, Animal. Hippurates / urine. Humans. Indican / urine. Ketoglutaric Acids / urine. Magnetic Resonance Spectroscopy. Male. Methylamines / urine. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Transplantation. Principal Component Analysis. Xenograft Model Antitumor Assays

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  • (PMID = 20954069.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Hippurates; 0 / Ketoglutaric Acids; 0 / Methylamines; 2968PHW8QP / Citric Acid; 328-50-7 / alpha-ketoglutaric acid; FLD0K1SJ1A / trimethyloxamine; N187WK1Y1J / Indican; TE0865N2ET / hippuric acid
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49. Chen CY, Chiou HJ, Chou SY, Chiou SY, Wang HK, Chou YH, Chiang HK: Computer-aided diagnosis of soft-tissue tumors using sonographic morphologic and texture features. Acad Radiol; 2009 Dec;16(12):1531-8
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  • [Title] Computer-aided diagnosis of soft-tissue tumors using sonographic morphologic and texture features.
  • RATIONALE AND OBJECTIVES: The aim of this study was to develop a computer-aided diagnosis (CAD) system in assessing the sonographic morphologic and texture features of soft-tissue tumors.
  • MATERIALS AND METHODS: The retrospective study involved 114 pathology proven cases including 73 benign and 41 malignant soft-tissue tumors.
  • The tumor regions were delineated by an experienced radiologist who was unknown to the pathologic result.
  • Then, we applied 10 morphologic features and 6 gray-level co-occurrence matrix texture features to analyze the tumor regions.
  • To classify the tumors as benign or malignant, we used two methods, a linear discriminant analysis with stepwise feature selection and a multilayer neural network with the back-propagation algorithm as classifiers.
  • Furthermore, four radiologists provided malignancy grades for all tumors in the comparison of the CAD system.
  • CONCLUSIONS: This study has shown that performing the CAD system with both morphologic and texture features on sonography, can successfully distinguish between benign and malignant soft-tissue tumors.
  • Moreover, it can also provide a second opinion for the tumor diagnosis and avert unnecessary biopsy.

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  • (PMID = 19896070.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Fang JQ, Shao XM, Ma GZ: [Effect of electroacupuncture at "Zusanli" (ST 36) and "Sanyinjiao" (SP 6) on collagen-induced arthritis and secretory function of knee-joint synoviocytes in rats]. Zhen Ci Yan Jiu; 2009 Apr;34(2):93-6
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  • CIA model (rheumatoid arthritis) was duplicated by intradermal injection of Bovine type II collagen into the back of the anesthetized rats.

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  • (PMID = 19685721.001).
  • [ISSN] 1000-0607
  • [Journal-full-title] Zhen ci yan jiu = Acupuncture research
  • [ISO-abbreviation] Zhen Ci Yan Jiu
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Interleukin-1beta; 0 / Tumor Necrosis Factor-alpha; K7Q1JQR04M / Dinoprostone
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51. Gould PS, Easton AJ: Coupled translation of the second open reading frame of M2 mRNA is sequence dependent and differs significantly within the subfamily Pneumovirinae. J Virol; 2007 Aug;81(16):8488-96
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  • Thus, the overlapping region can direct the ribosome back onto the start codon of the second ORF while the upstream coding sequence of the M2-1 ORF determines the levels of coupled expression.
  • [MeSH-minor] Amino Acid Sequence. Animals. Cell Line, Tumor. Humans. Mice. Molecular Sequence Data. Open Reading Frames. RNA, Messenger / chemistry. RNA, Messenger / metabolism. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism. Ribosomes / metabolism. Transcription, Genetic

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  • (PMID = 17522208.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Viral; 0 / Recombinant Fusion Proteins; 0 / Viral Matrix Proteins; 96380-51-7 / M2 protein, turkey rhinotracheitis pneumovirus
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52. Zheng Z, Qianqiao Z, Qi H, Feng X, Chunkang C, Xiao L: In vitro deprivation of CD8(+)CD57(+)T cells promotes the malignant growth of bone marrow colony cells in patients with lower-risk myelodysplastic syndrome. Exp Hematol; 2010 Aug;38(8):677-84
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  • After add-back of CD8(+)CD57(+) T cells (four times), none of the BMNCs cultures from any of the 59 MDS patients formed colonies in vitro.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Chromosome Aberrations. Coculture Techniques. Female. Humans. Lymphocyte Depletion. Male. Middle Aged. Tumor Cells, Cultured. Tumor Stem Cell Assay


53. Morgan CJ, Nyak N, Cooper A, Pees B, Friedmann PS: Multiple Spitz naevi: a report of both variants with clinical and histopathological correlation. Clin Exp Dermatol; 2006 May;31(3):368-71
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  • [MeSH-minor] Abdomen. Adult. Back. Biomarkers, Tumor / analysis. Biopsy, Needle. Child. Humans. Ki-67 Antigen / analysis. Male. S100 Proteins / analysis

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  • (PMID = 16681578.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / S100 Proteins
  • [Number-of-references] 11
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54. Cowden A, Dans M, Militello G, Junkins-Hopkins J, Van Voorhees AS: Eccrine porocarcinoma arising in two African American patients: distinct presentations both treated with Mohs micrographic surgery. Int J Dermatol; 2006 Feb;45(2):146-50
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  • Abstract Background Eccrine porocarcinoma (EPC) is a rare, malignant adnexal tumor that has been reported only three times specifically in African American individuals.
  • Diagnosis and treatment of EPC is important, given the 20% local recurrence and regional metastatic rates.
  • [MeSH-minor] Aged. Back. Female. Heel. Humans. Male. Middle Aged. Mohs Surgery

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  • (PMID = 16445507.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Wong CL, Mansberg R: Solitary plasmacytoma of bone: an unusual cause of severe sacral pain in a young man. Clin Nucl Med; 2005 Sep;30(9):612-4
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  • The mass demonstrated high glucose avidity consistent with a high-grade tumor.
  • [MeSH-major] Arthralgia / etiology. Arthralgia / radionuclide imaging. Bone Neoplasms / radionuclide imaging. Low Back Pain / etiology. Plasmacytoma / radionuclide imaging. Sacroiliac Joint / radionuclide imaging. Sacrum / radionuclide imaging

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  • (PMID = 16100481.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Zaider M, Zelefsky MJ, Cohen GN, Chui CS, Yorke ED, Hunt MA, Happersett L: The role of external beam in brachytherapy. Future Oncol; 2007 Apr;3(2):159-68
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  • In this paper we put forward the claim that the combination of low dose-rate brachytherapy (BRT) and fractionated external-beam radiotherapy (EBRT) may, when planned to take advantage of the relative advantages of each of these two modalities, result in enhanced tumor dose with no penalties to organs at risk.
  • The concept of iso-effective dose (IED) serves the role of common currency for fusing BRT and EBRT and, for evaluation purposes, converting back the resulting IED distribution into a biologically equivalent plan delivered by any single modality.

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  • (PMID = 17381416.001).
  • [ISSN] 1479-6694
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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57. Mohammad WM, Frost I, Moonje V: Outpatient laparoscopic adrenalectomy: a Canadian experience. Surg Laparosc Endosc Percutan Tech; 2009 Aug;19(4):336-7
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  • A call back system was put in place.
  • Tumor size ranged from 1 to 5.8 cm.
  • Call back systems should be instituted.

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  • (PMID = 19692886.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Cho S, Kim JH, Back SH, Jang SK: Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase. Mol Cell Biol; 2005 Feb;25(4):1283-97
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  • [Title] Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase.
  • The p27(Kip1) protein plays a critical role in the regulation of cell proliferation through the inhibition of cyclin-dependent kinase activity.
  • Translation of p27(Kip1) is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of p27(Kip1) mRNA.
  • Here, we report that polypyrimidine tract-binding protein (PTB) specifically enhances the IRES activity of p27(Kip1) mRNA through an interaction with the IRES element.
  • We found that addition of PTB to an in vitro translation system and overexpression of PTB in 293T cells augmented the IRES activity of p27(Kip1) mRNA but that knockdown of PTB by introduction of PTB-specific small interfering RNAs (siRNAs) diminished the IRES activity of p27(Kip1) mRNA.
  • Moreover, the G(1) phase in the cell cycle (which is maintained in part by p27(Kip1)) was shortened in cells depleted of PTB by siRNA knockdown.
  • 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced differentiation in HL60 cells was used to examine PTB-induced modulation of p27(Kip1) protein synthesis during differentiation.
  • The IRES activity of p27(Kip1) mRNA in HL60 cells was increased by TPA treatment (with a concomitant increase in PTB protein levels), but the levels of p27(Kip1) mRNA remained unchanged.
  • Together, these data suggest that PTB modulates cell cycle and differentiation, at least in part, by enhancing the IRES activity of p27(Kip1) mRNA.

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  • (PMID = 15684381.001).
  • [ISSN] 0270-7306
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / 27305C0011; United States / NIEHS NIH HHS / ES / 27307C0011; United States / NIEHS NIH HHS / ES / 27398C0011
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Phorbol Esters; 0 / RNA, Small Interfering; 0 / Tumor Suppressor Proteins; 139076-35-0 / Polypyrimidine Tract-Binding Protein; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ PMC548013
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59. Mitchel RE, Burchart P, Wyatt H: A lower dose threshold for the in vivo protective adaptive response to radiation. Tumorigenesis in chronically exposed normal and Trp53 heterozygous C57BL/6 mice. Radiat Res; 2008 Dec;170(6):765-75
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  • The exposures for shorter times (up to 60 weeks) appeared to be below the level necessary to induce overall protective adaptive responses in Trp53 normal mice, and detrimental effects (shortened life span, increased frequency) evident for only specific tumor types (B- and T-cell lymphomas) were produced.
  • Only when the exposures were continued for 90 weeks did the dose become sufficient to induce protective adaptive responses, balancing the detrimental effects for these specific cancers and reducing the risk level back to that of the unexposed animals.
  • Detrimental effects were not seen for other tumor types, and a protective effect was seen for sarcomas after 60 weeks of exposure, which was then lost when the exposure continued for 90 weeks.
  • [MeSH-major] Environmental Exposure. Heterozygote. Neoplasms / etiology. Neoplasms / metabolism. Radiation Dosage. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19138040.001).
  • [ISSN] 0033-7587
  • [Journal-full-title] Radiation research
  • [ISO-abbreviation] Radiat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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60. Vijay K, Venkateswaran K, Shetty AP, Rajasekaran S: Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegia. Eur Spine J; 2008 Sep;17 Suppl 2:S267-70
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  • A 57-year-old lady presented with a breast lump, multiple truncal skin swellings, low back pain and rapidly progressive paraplegia.
  • Posterior decompression and tumor debulking at all three sites of neural compression was performed.
  • Histopathology of the epidural tumor was consistent with MCC and the diagnosis was confirmed by immuno-histochemistry staining for cytokeratin-20.
  • One month after diagnosis she died due to extensive metastasis.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy. Breast Neoplasms / secondary. Decompression, Surgical. Disease Progression. Fatal Outcome. Female. Humans. Keratin-20 / analysis. Keratin-20 / metabolism. Magnetic Resonance Imaging. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / therapy. Neurosurgical Procedures. Treatment Failure

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  • [ISO-abbreviation] Eur Spine J
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61. Koido S, Homma S, Hara E, Namiki Y, Ohkusa T, Gong J, Tajiri H: Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells. J Biomed Biotechnol; 2010;2010:752381
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  • [Title] Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells.
  • The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass.
  • Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules.
  • Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs.
  • We will discuss perspectives for future development of DCs/tumor fusions for CTL induction.

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  • (PMID = 20379390.001).
  • [ISSN] 1110-7251
  • [Journal-full-title] Journal of biomedicine & biotechnology
  • [ISO-abbreviation] J. Biomed. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Epitopes; 0 / Histocompatibility Antigens
  • [Other-IDs] NLM/ PMC2850552
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62. Léveillé F, Papadia S, Fricker M, Bell KF, Soriano FX, Martel MA, Puddifoot C, Habel M, Wyllie DJ, Ikonomidou C, Tolkovsky AM, Hardingham GE: Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci; 2010 Feb 17;30(7):2623-35
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  • This mechanism is mediated by transcriptional suppression of apoptosome components Apaf-1 and procaspase-9, and limiting caspase-9 activity, since overexpression of procaspase-9 accelerates the rate of apoptosis in active neurons back to control levels.
  • [MeSH-minor] 4-Aminopyridine / pharmacology. Analysis of Variance. Animals. Animals, Newborn. Apoptosis Regulatory Proteins / deficiency. Apoptosis Regulatory Proteins / metabolism. Apoptotic Protease-Activating Factor 1 / metabolism. Bicuculline / pharmacology. Caspase 9 / metabolism. Cells, Cultured. Cerebral Cortex / cytology. Cytochromes c / metabolism. Dizocilpine Maleate / pharmacology. Dose-Response Relationship, Drug. Drug Combinations. Embryo, Mammalian. Enzyme Inhibitors / pharmacology. GABA Antagonists / pharmacology. Green Fluorescent Proteins / genetics. Male. Mice. Mice, Inbred C57BL. Mutation / genetics. Neuroprotective Agents / pharmacology. Potassium Channel Blockers. Staurosporine / pharmacology. Tacrolimus / analogs & derivatives. Tacrolimus / pharmacology. Time Factors. Transfection / methods. Tumor Suppressor Protein p53 / deficiency. Tumor Suppressor Protein p53 / metabolism. Tumor Suppressor Proteins / deficiency. Tumor Suppressor Proteins / metabolism. Up-Regulation / drug effects

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  • (PMID = 20164347.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 087491; United Kingdom / Wellcome Trust / / 87491; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AP20187; 0 / Apoptosis Regulatory Proteins; 0 / Apoptotic Protease-Activating Factor 1; 0 / Drug Combinations; 0 / Enzyme Inhibitors; 0 / GABA Antagonists; 0 / Neuroprotective Agents; 0 / PUMA protein, mouse; 0 / Potassium Channel Blockers; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 147336-22-9 / Green Fluorescent Proteins; 6LR8C1B66Q / Dizocilpine Maleate; 9007-43-6 / Cytochromes c; BH3B64OKL9 / 4-Aminopyridine; EC 3.4.22.- / Caspase 9; H88EPA0A3N / Staurosporine; WM0HAQ4WNM / Tacrolimus; Y37615DVKC / Bicuculline
  • [Other-IDs] NLM/ PMC2834927; NLM/ UKMS28795
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63. Zhang H, Xue ZL, Qi AM, Li S, Ye JD: [Antitumor effect of calcium phosphate cement incorporating doxorubicin microspheres]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Feb;30(2):278-83
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  • The cell suspension (0.1 ml) mixed with an equal volume of the cement extract were injected into the right buttock and on the back of the bilateral ears of nude mice.
  • At 12 days after the cell injection, the tumor tissues were obtained and weighed to calculate the tumor inhibition rate, and the pathological samples were observed with HE staining.
  • RESULTS: The extract of the bone cement containing doxorubicin microspheres showed inhibitory effects on the tumor growth in a dose-dependent manner.
  • The tumor inhibition rate reached 61.0% in high-dose group.
  • Tumor necrosis was found in high dose group, but virtually absent in low-dose group.
  • CONCLUSIONS: CPC containing doxorubicin PLGA microspheres can inhibit tumor cell growth both in vitro and in vivo.
  • [MeSH-minor] Animals. Bone Neoplasms / drug therapy. Bone Neoplasms / pathology. Cell Line, Tumor. Delayed-Action Preparations. Female. Male. Mice. Mice, Nude. Microspheres

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  • (PMID = 20159700.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Bone Cements; 0 / Calcium Phosphates; 0 / Delayed-Action Preparations; 80168379AG / Doxorubicin; 97Z1WI3NDX / calcium phosphate
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64. Jeanteur P: [miRNAs and cancer]. Bull Cancer; 2010 Nov;97(11):1231-9
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  • Indeed, the first report on a small RNA able to control the translation of a specific messenger RNA (and therefore called translational control RNA or tcRNA) dates 35-year back. miRNAs waited until 1993 to be "rediscovered" and become the focus of an intense research activity which led to the discovery of several hundreds of them, to the unraveling of their biosynthesis and of their involvement in numerous physiological and pathological processes, notably in cancer.
  • [MeSH-minor] Gene Expression Regulation, Neoplastic / physiology. Genes, Tumor Suppressor / physiology. Humans. Mutation / genetics. Oncogenes / physiology. Prognosis

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  • (PMID = 21059489.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / MicroRNAs
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65. Ho L, Valenzuela D, Negahban A, Wassef H: Primary spinal epidural non-Hodgkin lymphoma demonstrated by FDG PET/CT. Clin Nucl Med; 2010 Jul;35(7):487-9
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  • The HIV-positive patient presented with mid- to low back pain for several days, which progressed to lower extremity weakness and urinary retention.
  • In our case, the primary tumor appears as an intensely hypermetabolic soft-tissue mass involving the posterior epidural space from C6 through T9 levels.

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  • (PMID = 20548138.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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66. Roemer E, Ottmueller TH, Urban HJ, Baillet-Mignard C: SKH-1 mouse skin painting: a short-term assay to evaluate the tumorigenic activity of cigarette smoke condensate. Toxicol Lett; 2010 Feb 1;192(2):155-61
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  • The design chosen was the two-stage dermal tumorigenicity assay (skin painting), with tumor initiation using a single dermal application of the carcinogen/mutagen dimethylbenz(a)anthracene applied to the back at a non-tumorigenic dose and tumor promotion by repeated dermal applications of CSC at the same site.
  • The mice reproducibly developed skin tumors at the application site after 15 weeks at a frequency that allowed comparison of the treatment groups.
  • The histopathological examination revealed the benign nature of the tumors (keratotic papillomas).
  • Prolongation of the application period to 25 weeks resulted in the development of malignant tumors (carcinomas), indicating that the benign tumors after 15 weeks can be taken as surrogate endpoints for malignancies progressing after further treatment.
  • After 15 weeks, tumor incidence (the percentage of tumor-bearing mice), tumor multiplicity (the number of tumors per mouse), and tumor-onset (the duration of the application period that resulted in a meaningful tumor incidence) were positively correlated with the initiating and promoting dose.

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  • [Copyright] 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19854249.001).
  • [ISSN] 1879-3169
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Tobacco Smoke Pollution; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene
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67. Gaurnier-Hausser A, Tuszynski GP: The immunomodulatory role of angiocidin, a novel angiogenesis inhibitor. Curr Pharm Des; 2009;15(17):1937-48
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  • The observation that many tumors exist in a microenvironment comprised of immune cells has led to the hypothesis that the immune system may play a significant role in the suppression of tumor growth.
  • However, tumors have developed numerous mechanisms by which they avoid immune recognition and death.
  • Cancer immunotherapy attempts to harness the power of the immune system and direct it against tumor growth, while circumventing the immune-evasion strategies utilized by tumors.
  • Many approaches are currently being investigated, including the re-infusion of autologous immune effector cells (i.e. cytotoxic T lymphocytes and macrophages) back into hosts after ex vivo expansion and activation.
  • The therapeutic effects of specific cytokines are also being evaluated for their impact on tumor growth.
  • Our lab has discovered a novel thrombospondin-1 (TSP-1) binding protein, termed "angiocidin", with potent anti-tumor and anti-angiogenic capabilities.
  • To further investigate the anti-tumor activity of angiocidin, we examined whether angiocidin could play a role in immune system modulation.
  • Based on these data, we hypothesize that angiocidin's ability to elicit tumor cell death may be mediated in part by it's pro-inflammatory effects on immune cells in the tumor microenvironment.

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  • (PMID = 19519434.001).
  • [ISSN] 1873-4286
  • [Journal-full-title] Current pharmaceutical design
  • [ISO-abbreviation] Curr. Pharm. Des.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 88931
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Angiogenesis Inhibitors; 0 / Carrier Proteins; 0 / Cytokines; 0 / PSMD4 protein, human; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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68. Mandal D, Bhattacharyya A, Lahiry L, Choudhuri T, Sa G, Das T: Failure in peripheral immuno-surveillance due to thymic atrophy: importance of thymocyte maturation and apoptosis in adult tumor-bearer. Life Sci; 2005 Oct 7;77(21):2703-16
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  • [Title] Failure in peripheral immuno-surveillance due to thymic atrophy: importance of thymocyte maturation and apoptosis in adult tumor-bearer.
  • Tumor-induced immunosuppression often leads to failure in cancer therapy.
  • Here, in an attempt to understand the course of tumor-dependent immunosuppression in young adult murine model, we found that in Ehrlich's ascites carcinoma (EAC) bearing mice, CD4(+) and CD8(+) populations of peripheral blood were depleted within first week of tumor inoculation.
  • However, there was a rise in these populations at the end of second week only to fall back severely at the end of third week.
  • Interestingly, in thymus, production of CD4(+) and CD8(+) increased during first two weeks of tumor inoculation indicating the effort of thymus to replenish these populations in peripheral blood and spleen in response to their initial depletion, restricting tumor growth in between first and second weeks.
  • Above findings accounted for the significant decrease in CD4(+) and CD8(+) of peripheral blood and spleen by the end of third week culminating in total collapse in the fight back mechanism of host and uncontrolled growth of tumor.
  • All these results signify the importance of thymus in modulating the immune status of the host during tumor development.
  • [MeSH-major] Apoptosis / physiology. Carcinoma, Ehrlich Tumor / immunology. Immunologic Surveillance / physiology. T-Lymphocytes / physiology. Thymus Gland / immunology. Thymus Gland / pathology
  • [MeSH-minor] Animals. Annexin A5 / chemistry. Atrophy. CD4-CD8 Ratio. Cell Cycle. DNA / biosynthesis. DNA / genetics. Flow Cytometry. Fluorescein-5-isothiocyanate. Fluorescent Dyes. Genes, bcl-2. Longitudinal Studies. Mice. Neoplasm Transplantation. Proto-Oncogene Proteins c-bcl-2. Spleen / cytology. Spleen / immunology. bcl-2-Associated X Protein

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  • (PMID = 16019036.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Bax protein, mouse; 0 / Fluorescent Dyes; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; 9007-49-2 / DNA; I223NX31W9 / Fluorescein-5-isothiocyanate
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69. Panelos J, Beltrami G, Capanna R, Franchi A: Primary capillary hemangioblastoma of bone: report of a case arising in the sacrum. Int J Surg Pathol; 2010 Dec;18(6):580-3
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  • Capillary hemangioblastoma (CHB) is a benign, highly vascularized tumor that generally occurs in the central nervous system either in the setting of von Hippel-Lindau (VHL) disease or, more often, as a solitary sporadic lesion that is increasingly recognized in extraneural sites.
  • We present the case of a 72-year-old woman with low back pain and a well-demarcated lytic lesion of the sacrum, which at histological and ultrastructural examination was indistinguishable from central nervous system CHB.


70. Park P, Leveque JC, La Marca F, Sullivan SE: Dural closure using the U-clip in minimally invasive spinal tumor resection. J Spinal Disord Tech; 2010 Oct;23(7):486-9
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  • [Title] Dural closure using the U-clip in minimally invasive spinal tumor resection.
  • SUMMARY OF BACKGROUND DATA: Dural closure in minimally invasive spinal intradural tumor resection can be technically challenging.
  • RESULTS: Two patients presented with spinal intradural tumors.
  • Patient 1 presented with severe upper back pain and was found to have an intradural extramedullary mass at T2 causing severe spinal cord compression.
  • Both patients underwent minimally invasive tumor resection using an expandable tubular retraction system.

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  • (PMID = 20075749.001).
  • [ISSN] 1539-2465
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. John E, Pais P, Furtado N, Chin A, Radhakrishnan J, Fornell L, Lumpaopong A, Beier UH: Early effects of lipopolysaccharide on cytokine release, hemodynamic and renal function in newborn piglets. Neonatology; 2008;93(2):106-12
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  • One, 2, and 3 h later samples were taken to monitor tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, endothelin, and nitric oxide (NO)/nitrate via ELISA.
  • NO/nitrate, endothelin, and hemodynamic as well as metabolic changes became apparent mostly 3 h after exposure, by which time TNF-alpha and IL-1beta fell back to baseline.
  • [MeSH-minor] Animals. Biomarkers / blood. Blood Gas Analysis. Disease Models, Animal. Endothelins / blood. Gram-Negative Bacterial Infections / blood. Gram-Negative Bacterial Infections / physiopathology. Interleukin-1beta / blood. Nitric Oxide / blood. Sensitivity and Specificity. Swine. Tumor Necrosis Factor-alpha / blood. Vascular Resistance / drug effects. Vascular Resistance / physiology

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  • [Copyright] (c) 2007 S. Karger AG, Basel
  • (PMID = 17703105.001).
  • [ISSN] 1661-7819
  • [Journal-full-title] Neonatology
  • [ISO-abbreviation] Neonatology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cytokines; 0 / Endothelins; 0 / Interleukin-1beta; 0 / Lipopolysaccharides; 0 / Tumor Necrosis Factor-alpha; 31C4KY9ESH / Nitric Oxide
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72. Geller AC, Johnson TM, Miller DR, Brooks KR, Layton CJ, Swetter SM: Factors associated with physician discovery of early melanoma in middle-aged and older men. Arch Dermatol; 2009 Apr;145(4):409-14
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  • PARTICIPANTS: A total of 227 male participants (aged > or =40 years) with invasive melanoma who completed surveys within 3 months of diagnosis.
  • Physician-detected melanoma in the oldest patients (aged > or =65 years) had tumor thickness equal to that of self-detected melanoma or melanoma detected by other means in younger patients.
  • Back lesions composed 46% of all physician-detected melanoma, 57% of those detected by other means, and 16% of self-detected lesions (physician- vs self-detected: OR, 4.25; 95% CI, 1.96-9.23).
  • Ninety-two percent of all physician-detected back-of-the-body melanomas were smaller than 2 mm compared with 63% of self-detected lesions (P = .004) and 76% of lesions detected by other means (P = .07).
  • CONCLUSIONS: Skin screenings of at-risk middle-aged and older American men can be integrated into the routine physical examination, with particular emphasis on hard-to-see areas, such as the back of the body.
  • "Watch your back" professional education campaigns should be promoted by skin cancer advocacy organizations.
  • [MeSH-major] Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Dermatology. Early Diagnosis. Humans. Male. Middle Aged. Patient Education as Topic. Physicians. Self Care

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  • [CommentIn] JAMA. 2009 Apr 22;301(16):1702-4 [19388140.001]
  • (PMID = 19380662.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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73. Per H, Kumandaş S, Gümüş H, Yikilmaz A, Kurtsoy A: Iatrogenic epidermoid tumor: late complication of lumbar puncture. J Child Neurol; 2007 Mar;22(3):332-6
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  • [Title] Iatrogenic epidermoid tumor: late complication of lumbar puncture.
  • Intraspinal epidermoid tumors can be congenital and acquired.
  • Acquired intraspinal epidermoid tumors are extremely rare.
  • Approximately 40% of acquired epidermoid tumors are considered a late complication of lumbar puncture.
  • The authors report the case of an 8-year-old boy who presented with a 1-year history of back and hip pain and radiating pain to both thighs posterior.
  • The patient underwent total surgical excision of the epidermoid tumor.
  • Pathologic examination revealed the diagnosis of epidermoid tumor.
  • KEYWORDS: intraspinal epidermoid tumor; lumbar puncture; children.

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  • [CommentIn] J Child Neurol. 2008 Aug;23(8):969; author reply 969 [18660483.001]
  • (PMID = 17621507.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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74. Visokai V, Lipska L, Bergmann P, Levy M, Dutka J: Mesohepatectomy for colorectal liver metastasis. Case report. Hepatogastroenterology; 2005 Sep-Oct;52(65):1563-6
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  • Obstruction was caused by a tumor of the descending colon invading the abdominal wall.
  • At present the patient has no signs of recurrence, she has returned back to her normal life.
  • Despite several unfavorable prognostic factors--obstruction, abdominal wall infiltration, number of positive nodes, short time between primary tumor resection and diagnosis of liver metastasis and centrally located metastasis with satellite lesions, the patient has been surviving for 6 years now.
  • [MeSH-minor] Colonic Neoplasms / pathology. Female. Hepatic Veins / pathology. Hepatic Veins / radiography. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Invasiveness. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 16201120.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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75. Shinoda M, Hatano S, Kawakubo H, Kakefuda T, Omori T, Ishii S: Adult cecoanal intussusception caused by cecum cancer: report of a case. Surg Today; 2007;37(9):802-5
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  • We manually pushed the mass back into the rectum and performed a gastrograffin enema, which showed a cup-shaped filling defect in the rectum.
  • The defect was moved back to oral side with the pressure of the enema, revealing a tumor originating in the cecum.
  • Laparotomy confirmed that the tumor originated at the bottom of the appendix in the cecum.
  • We performed partial resection of the cecum containing the tumor and appendix.

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  • (PMID = 17713738.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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76. Nüesch JP, Lachmann S, Rommelaere J: Selective alterations of the host cell architecture upon infection with parvovirus minute virus of mice. Virology; 2005 Jan 5;331(1):159-74
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  • In contrast, disassembly of actin filaments late in infection could be traced back to the disregulation of two F-actin associated proteins gelsolin and Wiscott-Aldrich Syndrome Protein (WASP).

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  • (PMID = 15582663.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Isoenzymes; 0 / Vimentin; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / protein kinase C lambda
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77. Serratrice J, de Roux-Serratrice C, Disdier P, Dodé C, Weiller PJ: Dramatic etanercept-induced remission of relapsing febrile sciatic neuralgia related to p46l mutation of the tnfrsf1a gene. Clin Rheumatol; 2007 Sep;26(9):1535-6
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  • An adult patient experienced attacks of severe low back pain and sciatic neuralgia for several years, sometimes associated with myalgias, skin lesions, and high fever.
  • P46L mutation in the gene on chromosome 12p13 that encodes tumor necrosis factor receptor superfamily 1A (TNFRSF1A) was found.
  • [MeSH-major] Immunoglobulin G / therapeutic use. Receptors, Tumor Necrosis Factor / therapeutic use. Receptors, Tumor Necrosis Factor, Type I / genetics. Sciatica. Tumor Necrosis Factor-alpha / antagonists & inhibitors

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  • (PMID = 16941196.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Receptors, Tumor Necrosis Factor, Type I; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
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78. Oklejewicz M, Destici E, Tamanini F, Hut RA, Janssens R, van der Horst GT: Phase resetting of the mammalian circadian clock by DNA damage. Curr Biol; 2008 Feb 26;18(4):286-91
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  • Because circadian output processes can feed back into the clock, we investigated whether DNA damage affects the mammalian circadian clock.
  • Ionizing radiation-induced phase shifting depends on neither upregulation or downregulation of clock gene expression nor on de novo protein synthesis and, thus, differs mechanistically from dexamethasone- and forskolin-provoked clock resetting [5].
  • [MeSH-minor] Animals. Ataxia Telangiectasia Mutated Proteins. Cell Cycle Proteins / metabolism. Cell Line. DNA-Binding Proteins / metabolism. Gamma Rays / adverse effects. Gene Expression / drug effects. Gene Expression / radiation effects. Male. Mice. Mice, Inbred C57BL. Protein-Serine-Threonine Kinases / metabolism. Rats. Signal Transduction / radiation effects. Tumor Suppressor Proteins / metabolism

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  • (PMID = 18291650.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Atm protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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79. Szumiel I: L5178Y sublines: a look back from 40 years. Part 2: response to ionizing radiation. Int J Radiat Biol; 2005 May;81(5):353-65
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  • [Title] L5178Y sublines: a look back from 40 years. Part 2: response to ionizing radiation.
  • [MeSH-major] DNA Damage. Lymphoma / pathology. Radiation Injuries / physiopathology. Tumor Cells, Cultured

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  • (PMID = 16076750.001).
  • [ISSN] 0955-3002
  • [Journal-full-title] International journal of radiation biology
  • [ISO-abbreviation] Int. J. Radiat. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proteins; 0 / poly(ADP)-ribosylated proteins; 26656-46-2 / Poly Adenosine Diphosphate Ribose
  • [Number-of-references] 78
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80. Akutagawa O, Nishi H, Kyo S, Higuma C, Inoue M, Isaka K: Early growth response-1 mediates up-regulation of telomerase in placenta. Placenta; 2007 Aug-Sep;28(8-9):920-7
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  • It is also believed to wind back the "mitotic clock" which leads to ageing and enable permanent cell division.
  • [MeSH-minor] Cell Line, Tumor. DNA-Binding Proteins / genetics. Female. Humans. Placenta / metabolism. Pregnancy. Promoter Regions, Genetic. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17485108.001).
  • [ISSN] 0143-4004
  • [Journal-full-title] Placenta
  • [ISO-abbreviation] Placenta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / RNA, Messenger; EC 2.7.7.49 / Telomerase
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81. Koehler SM, Beasley MB, Chin CS, Wittig JC, Hecht AC, Qureshi SA: Synovial sarcoma of the thoracic spine. Spine J; 2009 Dec;9(12):e1-6
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  • BACKGROUND CONTEXT: Synovial sarcoma is an uncommon malignant neoplasm occurring chiefly in young adults.
  • Despite its proximity to joints, it has been well established that the tumor cells do not display features of synovial differentiation but instead appear to have a primitive epithelial phenotype.
  • METHODS: A 60-year-old man presented with a 5-month history of right upper quadrant abdominal pain radiating to his back in a band-like fashion; shortness of breath on exertion; and increasing pain when standing, sitting, or walking.
  • Absence of the tumor was shown by an MRI scan after the operation.
  • The diagnosis is supported by plain radiographs, bone scintigraphy, magnetic resonance and CT imaging studies, and histologic and immunohistochemical evidence.
  • A careful radiographic study of the tumor permitted early preliminary diagnosis, confirmed upon histopathologic analysis.
  • [MeSH-minor] Combined Modality Therapy. Early Diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radionuclide Imaging. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19800298.001).
  • [ISSN] 1878-1632
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Lutz MP, Pourebrahim S: [Pancreatic carcinoma]. Internist (Berl); 2008 Sep;49(9):1079-86; quiz 1087
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  • Most patients are elderly and typically present with dull upper abdominal pain radiating to the back and often report reduced appetite, weight loss, and jaundice.
  • A solid pancreatic tumor should be resected because this is the only chance for a cure.
  • Cystic tumors are usually less malignant and need further diagnostic work-up.
  • Locally advanced or metastatic tumors are treated symptomatically including pain medication and biliary drainage in the case of jaundice.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Ductal / diagnosis. Carcinoma, Ductal / therapy. Chemotherapy, Adjuvant / methods. Pancreatectomy / methods. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy

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  • [Cites] Internist (Berl). 2005 Feb;46(2):157-65 [15655682.001]
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  • (PMID = 18677456.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 14
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83. Sener G, Toklu HZ, Sehirli AO, Velioğlu-Oğünç A, Cetinel S, Gedik N: Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol Res; 2006 May;35(1):62-8
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  • Mice were sacrificed 4h after AA injection to determine serum ALT, AST and tumor necrosis factor-alpha (TNF-alpha) levels in blood, and glutathione (GSH), malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity and collagen contents in liver tissues.
  • On the other hand when RVT administered following AA, depletion of GSH and accumulation of MDA and neutrophil infiltration were reversed back to control.

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  • (PMID = 16595188.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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84. Mori N, Sawada T, Satoh H, Kawaguchi M, Hara H, Matsushita K: A resected case of solitary pancreatic metastasis from adenocarcinoma of the lung. JOP; 2008;9(6):698-703
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  • CASE REPORT: We report herein an unusual case of secondary tumor of the pancreas (primary tumor: adenocarcinoma of the lung) with hopefully curative resection.
  • [MeSH-major] Adenocarcinoma / diagnosis. Lung Neoplasms / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Back Pain / etiology. Humans. Male. Middle Aged. Neoplasm Metastasis. Recurrence. Shoulder Pain / etiology. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18981550.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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85. Bagi CM: Targeting of therapeutic agents to bone to treat metastatic cancer. Adv Drug Deliv Rev; 2005 May 25;57(7):995-1010
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  • Clinical confirmation of tumor spread to these organs is a negative prognostic sign that marks the stage when disease is rarely curable.
  • Significant improvements in our understanding of tumor biology along with early tumor detection has led to the discovery of few innovative approaches aimed to treat bone metastases.
  • The osteoclast, whose increased activity is induced by the tumor, is responsible for the deterioration of bone mass and structure along with the release of grow factors that feed back and support further tumor growth.
  • The current pharmaceutical approach is to target bone metastases by developing drugs that specifically target tumor cells in bone in addition to bone stroma since skeletal metastases are more resistant to treatment, present the highest bulk of tumor mass in the body, serve as site for secondary spread of tumor cells, and are associated with significant morbidity.


86. Liang JX, Weng SH, Chen JH: [Chaotic dynamic process of multiple organs dysfunction syndrome and the regulatory function of shenqin liquid on it]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2008 Jul;28(7):623-6
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  • Serum concentration of tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) in MODS model animals were tested diachronically, eg.
  • SQL can intervene the movement of TNF-alpha and NO, decrease the complexity of their chaotic movement, and make them return back to a stable state.

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  • (PMID = 18822913.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Tumor Necrosis Factor-alpha; 31C4KY9ESH / Nitric Oxide
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87. Malhi H, Gores GJ: Cancer therapy: back to metabolism. Cancer Biol Ther; 2006 Aug;5(8):986-7
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  • [Title] Cancer therapy: back to metabolism.
  • [MeSH-minor] Antigens, CD95 / antagonists & inhibitors. Antigens, CD95 / metabolism. Humans. Tumor Suppressor Protein p53 / antagonists & inhibitors. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors. p38 Mitogen-Activated Protein Kinases / genetics. p38 Mitogen-Activated Protein Kinases / metabolism

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  • [CommentOn] Cancer Biol Ther. 2006 Aug;5(8):978-85 [16855382.001]
  • (PMID = 16998303.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid; 0 / Antigens, CD95; 0 / Fatty Acids; 0 / Tumor Suppressor Protein p53; EC 2.3.1.85 / Fatty Acid Synthases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; OL659KIY4X / 4-Butyrolactone
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88. Bläsing H, Hendrix S, Paus R: Pro-inflammatory cytokines upregulate the skin immunoreactivity for NGF, NT-3, NT-4 and their receptor, p75NTR in vivo: a preliminary report. Arch Dermatol Res; 2005 Jun;296(12):580-4
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  • As a first step toward exploring this, we studied in murine back skin (C57BL/6) whether intradermally injected interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) altered the cutaneous immunoreactivity patterns of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), Trk-A, Trk-B, Trk-C and p75NTR and their receptors (TrkA, TrkB, TrkC, p75NTR) on the protein level in situ.
  • [MeSH-minor] Animals. Female. Immunohistochemistry. Interferon-gamma / pharmacology. Interleukin-1 / pharmacology. Mice. Mice, Inbred C57BL. Receptor, Nerve Growth Factor. Tumor Necrosis Factor-alpha / pharmacology. Up-Regulation

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  • (PMID = 15875206.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-1; 0 / Nerve Growth Factors; 0 / Neurotrophin 3; 0 / Receptor, Nerve Growth Factor; 0 / Receptors, Nerve Growth Factor; 0 / Tumor Necrosis Factor-alpha; 143551-63-7 / neurotrophin 4; 82115-62-6 / Interferon-gamma; 9061-61-4 / Nerve Growth Factor
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89. Bai X, Li P, Sun P, Li Y, Bao H, Lu Z, Cao Y, Guo J, Liu Z: [Virulence comparison of genetic engineering virus containing different length poly(C) tract of foot-and-mouth disease virus]. Wei Sheng Wu Xue Bao; 2008 Dec;48(12):1654-8
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  • The rescued virus was rejuvenated once in unweaned mice, and then came back to cell passage.
  • [MeSH-minor] Animals. Base Sequence. Cell Line. Cloning, Molecular. Foot-and-Mouth Disease Virus / genetics. Foot-and-Mouth Disease Virus / pathogenicity. Foot-and-Mouth Disease Virus / physiology. Genetic Engineering. Mice. RNA, Viral / chemistry. RNA, Viral / genetics. Tumor Cells, Cultured. Virus Cultivation. Virus Replication / physiology

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  • (PMID = 19274849.001).
  • [ISSN] 0001-6209
  • [Journal-full-title] Wei sheng wu xue bao = Acta microbiologica Sinica
  • [ISO-abbreviation] Wei Sheng Wu Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Viral; 30811-80-4 / Poly C
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90. Sierra-Montenegro E, Sierra-Luzuriaga G, Carrilo-Védova C, Leone-Stay G: Externalization of a soft tissue chordoma. Case report. Cir Cir; 2010 Nov-Dec;78(6):541-4
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  • BACKGROUND: Chordomas are rare, slow-growing tumors that originate in the primitive notochord.
  • On proctological examination, a tumor of 6 cm in diameter is found located in the midsacral region 3 cm from the anal canal.
  • On palpation, the tumor is hard and painless with a regular and mobile surface.
  • Diagnosis is made by imaging: x-ray of lumbosacral spine, computed tomography and magnetic resonance imaging.
  • CONCLUSIONS: Diagnosis of chordoma is rare but should be kept in mind in patients with pain in lower back or coccyx and, even more so, if accompanied by a mass with years of evolution.

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  • (PMID = 21214993.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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91. Weinrich M, Pistorius GA, Wagner M, Schilling MK, Maurer CA: [An adrenal pseudocyst as the cause of chronic back pain]. Orthopade; 2005 Dec;34(12):1263-6
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  • [Title] [An adrenal pseudocyst as the cause of chronic back pain].
  • We present the case of a 36 year old female patient with a 3 month history of severe lower back pain without improvement after physiotherapy and analgesic drug therapy.
  • A cystic tumor projecting on the posterior area of the right liver lobe was seen using ultrasound.
  • MRI-scan showed an extrahepatic localization of the tumor.
  • Intraoperatively, the tumor was located in the right adrenal gland which was then removed.
  • [MeSH-major] Adrenal Gland Diseases / diagnosis. Adrenal Gland Diseases / surgery. Back Pain / diagnosis. Back Pain / prevention & control. Cysts / diagnosis. Cysts / surgery

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  • (PMID = 16205888.001).
  • [ISSN] 0085-4530
  • [Journal-full-title] Der Orthopäde
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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92. Richardson PG, Chanan-Khan AA, Alsina M, Albitar M, Berman D, Messina M, Mitsiades CS, Anderson KC: Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study. Br J Haematol; 2010 Aug;150(4):438-45
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  • Non-haematological AEs included diarrhoea (59%), back pain (35%), fatigue (38%), and nausea (35%); haematological AEs included anaemia (24%) and thrombocytopenia (21%).

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  • (PMID = 20618337.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA078378-10; United States / NCI NIH HHS / CA / P01 CA078378; United States / NCI NIH HHS / CA / R01 CA050947; United States / NCI NIH HHS / CA / P01 CA078378-10
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzoquinones; 0 / Biomarkers, Tumor; 0 / HSP70 Heat-Shock Proteins; 0 / HSP90 Heat-Shock Proteins; 0 / Lactams, Macrocyclic; 4GY0AVT3L4 / tanespimycin
  • [Other-IDs] NLM/ NIHMS284456; NLM/ PMC3126095
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93. Kawakami H, Kuwatani M, Fujiya Y, Uebayashi M, Konishi K, Makiyama H, Hashino S, Kubota K, Itoh T, Asaka M: [A case of granulocyte-colony stimulating factor producing ductal adenocarcinoma of the pancreas]. Nihon Shokakibyo Gakkai Zasshi; 2007 Feb;104(2):233-8
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  • A 56-year-old Japanese man was admitted to our hospital with back pain and high fever.
  • A biopsy specimen of the hepatic tumor demonstrated metastatic poorly differentiated adenocarcinoma.
  • The diagnosis of autopsy was pancreatic ductal adenocarcinoma.
  • Immunohistochemical staining showed the presence of G-CSF in tumor cells.
  • The final diagnosis was G-CSF-producing pancreatic carcinoma.

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  • (PMID = 17283419.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Interleukin-6; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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94. Scottish Bone Tumor Registry, Sharma H, Mehdi SA, MacDuff E, Reece AT, Jane MJ, Reid R: Paget sarcoma of the spine: Scottish Bone Tumor Registry experience. Spine (Phila Pa 1976); 2006 May 20;31(12):1344-50
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  • [Title] Paget sarcoma of the spine: Scottish Bone Tumor Registry experience.
  • STUDY DESIGN: Retrospective case study of 13 cases of Paget sarcoma of the spine accrued from a prospectively collected Tumor Registry database.
  • SUMMARY OF BACKGROUND DATA: Paget disease of bone is a common disorder with the spine being involved in over 50% of patients.
  • METHODS: Between January 1944 and December 2003, 89 patients were registered with a diagnosis of Paget sarcoma in the Scottish Bone Tumor Registry.
  • The mode of presentation was progressively increasing low back pain (in all 13), unilateral sciatica (six; left-sided, five; right-sided, one), bilateral sciatica (two), lower limb weakness (eight), and autonomic dysfunction (four).


95. Lee DH, Kang SG, Jeong S, Yoon CJ, Choi JA, Byun JN, Park JH, Lee KB: Local delivery system of immune modulating drug for unresectable adenocarcinoma: in vitro experimental study and in vivo animal study. Cardiovasc Intervent Radiol; 2006 Sep-Oct;29(5):832-7
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  • OK-432-impregnated DDS was implanted in mice in which a human adenocarcinoma cell line was injected and grown in their back.
  • [MeSH-minor] Animals. Cell Line, Tumor. Drug Implants. Gastrointestinal Neoplasms / drug therapy. In Vitro Techniques. Membranes, Artificial. Mice. Mice, Inbred BALB C. Neoplasm Transplantation. Polycarboxylate Cement. Polyurethanes

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  • (PMID = 16779692.001).
  • [ISSN] 0174-1551
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Implants; 0 / Immunologic Factors; 0 / Membranes, Artificial; 0 / Polycarboxylate Cement; 0 / Polyurethanes; 25766-59-0 / polycarbonate; 39325-01-4 / Picibanil
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96. Dujardin F, Beaussart P, de Muret A, Rosset P, Waynberger E, Mulleman D, de Pinieux G: Primary neuroendocrine tumor of the sacrum: case report and review of the literature. Skeletal Radiol; 2009 Aug;38(8):819-23
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  • [Title] Primary neuroendocrine tumor of the sacrum: case report and review of the literature.
  • Primary carcinoid tumor (well-differentiated neuroendocrine tumor) of the bone involving the sacrum is extremely rare.
  • We report the case of a 72-year-old man who presented with a 20-year history of intermittent low back pain and was found to have an intraosseous sacral mass on imaging.
  • A needle biopsy revealed that this lesion was a well-differentiated neuroendocrine tumor.
  • Workup did not show any primary tumor or other metastatic disease.
  • A review of the literature revealed 20 case reports of neuroendocrine tumors arising from the presacral region (with or without associated tailgut cyst or sacrococcygeal teratoma) and sometimes extending to the sacrum.
  • Our case is the only tumor arising primarily from the sacrum.
  • The long evolution of this lesion without any other location makes metastatic disease very improbable and this case appears to be a unique example of primary intraosseous sacral carcinoid tumor.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroendocrine Tumors / diagnosis. Sacrum / diagnostic imaging. Sacrum / pathology. Spinal Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 19360403.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 29
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97. Kawakami N, Yamaguti S, Okuyama M, Katoh Y, Takashita N: [Two cases of silicate urolithiasis]. Hinyokika Kiyo; 2006 Jan;52(1):49-53
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  • Case 1: A 31-year-old woman with the chief complaint of right back pain was referred to our hospital.
  • No tumor was observed by cystourethroscopy, but a right ureteral stone was found by computerized tomography.

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  • (PMID = 16479991.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Silicates; 2612HC57YE / Calcium Oxalate
  • [Number-of-references] 13
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98. Poirier-Quinot M, Ginefri JC, Girard O, Robert P, Darrasse L: Performance of a miniature high-temperature superconducting (HTS) surface coil for in vivo microimaging of the mouse in a standard 1.5T clinical whole-body scanner. Magn Reson Med; 2008 Oct;60(4):917-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Typical SNR gains of 9.8, 9.8, 5.4, and 11.6 were found for brain, knee, back, and subcutaneous implanted tumors, respectively, over a series of mice.
  • [MeSH-minor] Animals. Cell Line, Tumor. Electric Conductivity. Equipment Design. Equipment Failure Analysis. Mice. Mice, Nude. Miniaturization. Reproducibility of Results. Sensitivity and Specificity

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18816812.001).
  • [ISSN] 1522-2594
  • [Journal-full-title] Magnetic resonance in medicine
  • [ISO-abbreviation] Magn Reson Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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99. Gokhan GA, Akyuz M, Gurer IE, Tuncer R: Epithelioid hemangioendothelioma derived from the spine region: case report and review of the literature. Wien Klin Wochenschr; 2006 Jun;118(11-12):358-61
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  • Epithelioid hemangioendotheliomas (EHE) are rare vascular tumors which generally originate from soft tissues and visceral organs.
  • Our case is that of a 30-year-old man who was admitted to hospital with low back pain, difficulty in walking, post-voiding urinary incontinence and numbness in the caudal area.
  • Vertebrectomy of L1 and gross total tumor resection were performed.
  • Histopathological and immunohistochemical findings of the tumor tissue supported the diagnosis of EHE.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Soft Tissue Neoplasms / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Rare Diseases / diagnosis

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  • (PMID = 16855926.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 19
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100. Rekhi B, Karpate A, Deodhar KK, Chinoy RF: Metastatic rhabdomyosarcomatous elements, mimicking a primary sarcoma, in the omentum, from a poorly differentiated ovarian Sertoli-Leydig cell tumor in a young girl: an unusual presentation with a literature review. Indian J Pathol Microbiol; 2009 Oct-Dec;52(4):554-8
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  • [Title] Metastatic rhabdomyosarcomatous elements, mimicking a primary sarcoma, in the omentum, from a poorly differentiated ovarian Sertoli-Leydig cell tumor in a young girl: an unusual presentation with a literature review.
  • Sertoli-Leydig cell tumors (SLCTs) of the ovary with mesenchymal heterologous elements are uncommon.
  • The sections from her ovarian mass for which she was operated a year back displayed features of a poorly differentiated SLCT with heterologous elements, including focal rhabdomyoblastic differentiation.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Rhabdomyosarcoma / diagnosis. Rhabdomyosarcoma / secondary. Sertoli-Leydig Cell Tumor / diagnosis

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  • (PMID = 19805972.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Desmin; 68238-35-7 / Keratins
  • [Number-of-references] 10
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