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1. Simó C, Rizzi A, Barbas C, Cifuentes A: Chiral capillary electrophoresis-mass spectrometry of amino acids in foods. Electrophoresis; 2005 Apr;26(7-8):1432-41
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  • Two different derivatization protocols of amino acids using dansyl chloride (DNS) and fluorescein isothiocyanate (FITC) are compared in terms of MS sensitivity and chiral resolution.
  • Under optimum CE-MS conditions it is observed that the MS sensitivity obtained for FITC- and DNS-amino acids is similar (with limit of detection (LOD) in the microM range, corresponding to amounts injected in the fmol range) while chiral resolution is better for FITC-amino acids.

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  • (PMID = 15759299.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Amino Acids
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2. Ciferri A: Bond scrambling and network elasticity. Chemistry; 2009 Jul 13;15(28):6920-5
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  • Dynamic networks (DNs) recently reported in the literature are based on cross-linked supramolecular chains or on covalent chains with reversible bonds.
  • Accordingly, a permanent set of the resting length of DNs should generally be expected and set materials should retain long-range elasticity relative to the set state.
  • However, only a limited set is shown by DNs, implying that a strong memory of the initial network topology assists elastic recovery of the original dimensions.
  • In this respect, DNs show better rubber behavior than typical covalent networks.
  • Consistently with theoretical predictions, this surprising finding suggests that bond scrambling relieves local strain constraints on the fluctuations of networks junctions and favors the recovery of the initial network topology.

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  • (PMID = 19499558.001).
  • [ISSN] 1521-3765
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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3. Lange JR, Balch CM: Screening for cutaneous melanoma. Surg Oncol Clin N Am; 2005 Oct;14(4):799-811
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  • [Title] Screening for cutaneous melanoma.
  • Current data do not support widespread population-based screening for melanoma.
  • While the incidence of melanoma is high, the overall mortality is low, and thus any potential benefit of screening the general population is hard to demonstrate.
  • Efforts should be focused on populations at particularly high risk of developing melanoma and on those at high risk of death from melanoma once diagnosed.
  • Persons in kindreds of familial melanoma, and persons who have atypical mole syndrome, those who have a prior diagnosis of melanoma, or those who have diagnosed atypical nevi are all reasonable candidates for routine screening, based on lower-level evidence in the absence of randomized clinical trials targeting these groups.
  • Programs targeting persons of low socioeconomic status and targeting white men over the age of 50 could address groups known to beat especially high risk of melanoma mortality.
  • [MeSH-major] Melanoma / diagnosis. Melanoma / prevention & control. Skin Neoplasms / diagnosis. Skin Neoplasms / prevention & control

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  • (PMID = 16226692.001).
  • [ISSN] 1055-3207
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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4. Tomioka K, Miyasako Y, Umezaki Y: PDF as a coupling mediator between the light-entrainable and temperature-entrainable clocks in Drosophila melanogaster. Acta Biol Hung; 2008;59 Suppl:149-55
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  • The light-entrainable clock consists of the clock neurons located in the lateral protocerebrum (LNs) and the temperature-entrainable clock involves those located in the dorsal protocerebrum (DNs) and the cells located in the posterior lateral protocerebrum (LPNs).

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  • (PMID = 18652387.001).
  • [ISSN] 0236-5383
  • [Journal-full-title] Acta biologica Hungarica
  • [ISO-abbreviation] Acta. Biol. Hung.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Drosophila Proteins; 0 / Neuropeptides; 0 / pdf protein, Drosophila
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5. Thorpe JR, Tang H, Atherton J, Cairns NJ: Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy. J Neural Transm (Vienna); 2008 Dec;115(12):1661-71
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  • TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of the pathological inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy, also called FTLD with ubiquitin-positive, tau-negative inclusions (FTLD-U), and motor neuron disease (MND).
  • In FTLD with TDP-43 proteinopathy, neuronal inclusions present variably as cytoplasmic inclusions (NCIs), dystrophic neurites (DNs), and intranuclear inclusions (NIIs), leading to a fourfold neuropathological classification correlating with genotype.
  • Thus, we undertook an immunoelectron microscopic study of FTLD with TDP-43 proteinopathy, including sporadic and familial cases with progranulin (GRN) mutation.

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  • (PMID = 18974920.001).
  • [ISSN] 0300-9564
  • [Journal-full-title] Journal of neural transmission (Vienna, Austria : 1996)
  • [ISO-abbreviation] J Neural Transm (Vienna)
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / P50 AG05681; United States / NIA NIH HHS / AG / P01 AG003991; United States / NIA NIH HHS / AG / P50 AG005681; United States / NIA NIH HHS / AG / P01 AG03991; United States / NIA NIH HHS / AG / P50 AG005681-26; United States / NIA NIH HHS / AG / P01 AG003991-26; United Kingdom / Wellcome Trust / / GR066166AIA
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / GRN protein, human; 0 / Intercellular Signaling Peptides and Proteins
  • [Other-IDs] NLM/ NIHMS152231; NLM/ PMC2789307
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6. Freeman R, McWilliams C, Gorter R, Williams S: Dental students interacting with dental nurses: an investigation of the role of gender and ethnicity in inter-professional communication and working styles. Br Dent J; 2007 Jan 27;202(2):91-6
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  • AIM: To examine the influence of dental students' gender and ethnicity on their perceptions of dental nurses' duties and upon their communication and working styles when interacting with dental nurses (DNs).
  • CONCLUSIONS: This survey illustrates the different communication and working styles used by male and female and dental students from different ethnic backgrounds when interacting and working with DNs.

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  • (PMID = 17255993.001).
  • [ISSN] 1476-5373
  • [Journal-full-title] British dental journal
  • [ISO-abbreviation] Br Dent J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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7. Driscoll MS, Grant-Kels JM: Nevi and melanoma in the pregnant woman. Clin Dermatol; 2009 Jan-Feb;27(1):116-21
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  • [Title] Nevi and melanoma in the pregnant woman.
  • Multiple difficult questions arise when a pregnant woman presents to the dermatologist with a changing melanocytic nevus or melanoma.
  • Women who have dysplastic nevus syndrome require closer monitoring during pregnancy.
  • For the pregnant woman with a confirmed, localized melanoma, prognosis does not appear to be affected by pregnancy.
  • Likewise, limited data indicate that pregnancy before or after a diagnosis of melanoma does not affect prognosis.
  • There appears to be no absolute contraindication to the prescription of oral contraceptive pills or hormone replacement therapy in someone who has been previously diagnosed with melanoma if no reasonable alternative exists.
  • [MeSH-major] Melanoma. Nevus. Pregnancy Complications, Neoplastic. Skin Neoplasms


8. Newton Bishop JA, Gruis NA: Genetics: what advice for patients who present with a family history of melanoma? Semin Oncol; 2007 Dec;34(6):452-9
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  • [Title] Genetics: what advice for patients who present with a family history of melanoma?
  • A significantly increased susceptibility to melanoma may manifest as a family history of melanoma (plus or minus pancreatic cancer), the development of multiple primary tumors, or melanoma in the context of numerous and clinically atypical moles (the atypical mole syndrome).
  • Melanoma is causally related to sun exposure in the majority of patients, although the patterns of sun exposure, which are most important, remain controversial.
  • [MeSH-major] Genetic Counseling. Genetic Testing. Melanoma / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Dysplastic Nevus Syndrome / genetics. Genes, p16. Genetic Predisposition to Disease. Humans. Models, Genetic. Pedigree. Skin Pigmentation / genetics

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  • (PMID = 18083368.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA-083115-06
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
  • [Number-of-references] 76
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9. Zhao Y, Zhong Z: Detection of Hg2+ in aqueous solutions with a foldamer-based fluorescent sensor modulated by surfactant micelles. Org Lett; 2006 Oct 12;8(21):4715-7
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  • [structure: see text] A hybrid foldamer constructed from six cholate units and two methionines was labeled with a DANSYL (DNS) group.

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  • (PMID = 17020285.001).
  • [ISSN] 1523-7060
  • [Journal-full-title] Organic letters
  • [ISO-abbreviation] Org. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluorescent Dyes; 0 / Micelles; 0 / Solutions; 059QF0KO0R / Water; AE28F7PNPL / Methionine; FXS1BY2PGL / Mercury
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10. Nielsen K, Harbst K, Måsbäck A, Jönsson G, Borg A, Olsson H, Ingvar C: Swedish CDKN2A mutation carriers do not present the atypical mole syndrome phenotype. Melanoma Res; 2010 Aug;20(4):266-72
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  • [Title] Swedish CDKN2A mutation carriers do not present the atypical mole syndrome phenotype.
  • Phenotypic characteristics were examined in melanoma-prone southern Swedish CDKN2A (p16-113insArg/p14ARF-128insSer) mutation families, in relation to the CDKN2A genotype, nevi, clinically atypical nevi (CAN) and melanoma.
  • Individuals from eight melanoma-prone families, with index patients carrying the CDKN2A mutation, were offered skin examinations and genotyping (CDKN2A and MC1R).
  • A significant correlation to CAN (P=0.01) and red hair colour (P=0.02) could be confirmed in melanoma patients.
  • A positive mutation status (CDKN2A) was correlated to one or more CAN (P=0.007) but neither to blue eyes, red hair colour, heavy freckling nor high number of nevi.
  • For mutation carriers, median total naevus count was 24 and interquartile range was 12-47 (mean 31); whereas for the whole cohort, median total naevus count was 12 and interquartile range was 5-25 (mean 22).
  • No participant fulfilled the atypical mole syndrome phenotype criteria.
  • Melanomas were diagnosed only in mutation carriers, and melanoma diagnosis was statistically correlated to the presence of one or more CAN and red hair colour, supporting the possible synergistic effect of a MC1R mutation on increased risk of melanoma in patients with a CDKN2A mutation.
  • Family history, with verified tumour diagnoses, remains an important clinical tool for finding mutation carriers for referral to clinical geneticists and simultaneous presence of CAN in probable mutation carriers might strengthen this indication.
  • The atypical mole syndrome phenotype was, however, not verified in the studied families and total naevus counts were low.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Dysplastic Nevus Syndrome / genetics. Germ-Line Mutation. Melanoma / genetics. Skin Neoplasms / genetics

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  • (PMID = 20526219.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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11. Lin W, Armfield SW: Unsteady natural convection on an evenly heated vertical plate for Prandtl number Pr< 1. Phys Rev E Stat Nonlin Soft Matter Phys; 2005 Dec;72(6 Pt 2):066309
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  • The transient behavior of the natural convection boundary-layer flow adjacent to a vertical plate heated with a uniform flux in a quiescent homogeneous ambient fluid with Prandtl number Pr<1 is investigated by scaling analysis and direct numerical simulation (DNS).
  • A series of DNS with selected values of Ra and Pr in the ranges of 10(6)< or =R< or =10(10) and 0.01< or =Pr < or =0.5 are used to validate the scaling laws and obtain scaling constants.

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  • (PMID = 16486061.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Haenssle HA, Krueger U, Vente C, Thoms KM, Bertsch HP, Zutt M, Rosenberger A, Neumann C, Emmert S: Results from an observational trial: digital epiluminescence microscopy follow-up of atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in detecting melanoma. J Invest Dermatol; 2006 May;126(5):980-5
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  • [Title] Results from an observational trial: digital epiluminescence microscopy follow-up of atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in detecting melanoma.
  • We analyzed the value of digital epiluminescence microscopy (DELM) for the long-term follow-up of atypical nevi.
  • Patients (n=530) were prospectively categorized into defined melanoma risk groups and followed by clinical and epiluminescence microscopy (ELM) examinations.
  • Atypical nevi (n=7001) were additionally followed by DELM.
  • The chance of success for melanoma detection among lesions suspicious by ELM criteria was increased to 17% when additional DELM-documented changes were present.
  • Excisions due to mere DELM changes detected 66.7% of melanomas in familial atypical mole and multiple melanoma (FAMMM) and 32.5% of melanomas in atypical mole syndrome (AMS) patients.
  • We conclude that DELM is a valuable tool for the long-term follow-up of atypical nevi, especially in the high-risk groups of FAMMM and AMS patients.
  • [MeSH-major] Image Processing, Computer-Assisted. Melanoma / diagnosis. Microscopy. Nevus, Pigmented / pathology. Skin Neoplasms / diagnosis


13. Ritchey T, Stichler JF: Determining the optimal number of patient rooms for an acute care unit. J Nurs Adm; 2008 Jun;38(6):262-6
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  • Stichler, DNS, RN, FACHE, prepares nurse leaders to use the evidence-based design process to ensure that new, expanded, and renovated hospitals facilitate optimal patient outcomes, enhance the work environment for healthcare providers, and improve organizational performance.

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  • (PMID = 18562828.001).
  • [ISSN] 1539-0721
  • [Journal-full-title] The Journal of nursing administration
  • [ISO-abbreviation] J Nurs Adm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Rocchini D: Algorithmic foundation of spectral rarefaction for measuring satellite imagery heterogeneity at multiple spatial scales. Sensors (Basel); 2009;9(1):303-10
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  • An algorithmic solution of rarefaction applied to image pixel values (Digital Numbers, DNs) is provided and discussed.

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  • [Cites] Ecol Lett. 2006 Aug;9(8):923-32 [16913935.001]
  • (PMID = 22389600.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3280746
  • [Keywords] NOTNLM ; algorithmic solution of rarefaction (major topic) / rarefaction theory (major topic) / satellite imagery (major topic) / spectral heterogeneity (major topic)
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15. Radl S, Khinast JG: Prediction of mass transfer coefficients in non-Newtonian fermentation media using first-principles methods. Biotechnol Bioeng; 2007 Aug 1;97(5):1329-34
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  • The method we used is a Direct Numerical Simulation (DNS) of the reactive multiphase flow with deformable boundaries and interfaces.

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17216657.001).
  • [ISSN] 0006-3592
  • [Journal-full-title] Biotechnology and bioengineering
  • [ISO-abbreviation] Biotechnol. Bioeng.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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16. Candela G, Varriale S, Di Libero L, Giordano M, Maschio A, Manetta F, Borrelli V, Nunziata A, Santini L: Carcinoid of the vermiform appendix. Description of three clinical cases and review of the literature. Minerva Chir; 2006 Jun;61(3):265-72
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  • Carcinoids of the appendix represent a separate class of tumours with characteristics that vary between benign (adenomas) and malignant (carcinomas) neoplasias.
  • A recent nomenclature identifies them as diffuse neuroendocrine system (DNS) and/or, parallely, as neuroendocrine tumours (NET): the gastroenteric tract is the site of about 64.3% of carcinoids, followed by the respiratory tract with 25.3%.
  • Treatment with somatostatin, on the other hand, proved effective in controlling tumour secretion, so attenuating the inconveniences of carcinoid syndrome.

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  • (PMID = 16858310.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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17. Xenos M, Girdhar G, Alemu Y, Jesty J, Slepian M, Einav S, Bluestein D: Device Thrombogenicity Emulator (DTE)--design optimization methodology for cardiovascular devices: a study in two bileaflet MHV designs. J Biomech; 2010 Aug 26;43(12):2400-9
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  • Transient turbulent and direct numerical simulations (DNS) were conducted, and stress loading histories experienced by the platelets were calculated along flow trajectories.

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20483411.001).
  • [ISSN] 1873-2380
  • [Journal-full-title] Journal of biomechanics
  • [ISO-abbreviation] J Biomech
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / R01 EB008004-02; United States / NIBIB NIH HHS / EB / EB008004-01; United States / NIBIB NIH HHS / EB / R01 EB008004-01; United States / NIBIB NIH HHS / EB / EB008004-03; United States / NIBIB NIH HHS / EB / 1R01EB008004-01; United States / NIBIB NIH HHS / EB / EB008004-02; United States / NIBIB NIH HHS / EB / R01 EB008004-03; United States / NIBIB NIH HHS / EB / R01 EB008004
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants
  • [Other-IDs] NLM/ NIHMS203813; NLM/ PMC2922449
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18. Wälivaara BM, Andersson S, Axelsson K: Views on technology among people in need of health care at home. Int J Circumpolar Health; 2009 Apr;68(2):158-69
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  • METHODS: District nurses (DNs) from 4 health care centres in Northern Sweden had access to different kinds of distance-spanning technology with mobile devices and who used it in their health care at home.

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  • (PMID = 19517875.001).
  • [ISSN] 1239-9736
  • [Journal-full-title] International journal of circumpolar health
  • [ISO-abbreviation] Int J Circumpolar Health
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Wada S, Kanzaki R: Neural control mechanisms of the pheromone-triggered programmed behavior in male silkmoths revealed by double-labeling of descending interneurons and a motor neuron. J Comp Neurol; 2005 Apr 4;484(2):168-82
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  • These activities are shown by certain descending interneurons contained in two subsets of DNs, Group-I and -II DNs.
  • However, it is not yet well understood which DNs are directly related to instructing this behavior.
  • In order to understand neural control mechanisms of this programmed behavior, we investigated the morphological relationship between these DNs and the cv1-NMN, which is an index of this programmed behavior.
  • We applied a double-labeling technique combining backfilling of the cv1-NMN and intracellular staining of single DNs.
  • 3D confocal images revealed overlapping regions between the Group-I, -II DNs and the cv1-NMN.
  • Group-IIA and -IID, which showed typical flipflop activities, Group-IIC DNs, which showed phasic excitation, and Group-IB DNs, which showed long-lasting inhibition had many overlapping regions on the cv1-NMNs.
  • Our results indicate that the programmed behavior is instructed by these types of DNs.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15736224.001).
  • [ISSN] 0021-9967
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pheromones
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20. Becker MO, Müller-Ladner U, Riemekasten G: [Towards an implementation of guidelines for the therapy of systemic sclerosis (scleroderma): between desire and reality]. Z Rheumatol; 2010 Jun;69(4):310-7
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  • However, due to the low prevalence and high variation in clinical signs and symptoms of the disease, there are only few high quality clinical trials.


21. Chumakov SG: A priori study of subgrid-scale flux of a passive scalar in isotropic homogeneous turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2008 Sep;78(3 Pt 2):036313
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  • We perform a direct numerical simulation (DNS) of forced homogeneous isotropic turbulence with a passive scalar that is forced by mean gradient.
  • The DNS data are used to study the properties of subgrid-scale flux of a passive scalar in the framework of large eddy simulation (LES), such as alignment trends between the flux, resolved, and subgrid-scale flow structures.

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  • (PMID = 18851149.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Marsili V, Lupidi G, Berellini G, Calzuola I, Perni S, Cruciani G, Gianfranceschi GL: Interaction of DDSDEEN peptide with N-CAM protein. Possible mechanism enhancing neuronal differentiation. Peptides; 2008 Dec;29(12):2232-42
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  • The binding causes a quenching of the Dns-peptide fluorescence emission.
  • Dose- and time-dependent binding of Dns-peptide with N-CAM has been shown.
  • Fluorescence quenching is completely lost if the Dns-peptide is subjected to carboxypeptidase digestion.
  • The Dns-peptide-N-CAM bond has been related to the peptide biological activity probably involved in the promotion of neuronal differentiation.
  • An attempt to recognize a possible N-CAM binding site for Dns-peptide was performed by alignment of N-CAM from various sources with some sequences that have been previously reported as binding sites for the pEDDSDEEN and DDSDEEN peptides.

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  • (PMID = 18852000.001).
  • [ISSN] 0196-9781
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecules; 0 / Oligopeptides; 0 / aspartyl-aspartyl-seryl-aspartyl-glutamyl-glutamyl-asparagine; EC 3.4.17.1 / Carboxypeptidases A
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23. Höglinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, Degregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S: The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A; 2007 Feb 27;104(9):3585-90
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  • [Title] The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease.
  • The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia nigra of patients with Parkinson's disease (PD) are not completely understood.
  • We further demonstrate that the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine injected into mice and application of its active metabolite 1-methyl-4-phenylpyridinium to mesencephalic cultures activate the retinoblastoma-E2F pathway in postmitotic DNs.
  • We also find that cell death rather than mitotic division followed the toxin-induced replication of DNA, as determined by BrdU incorporation in DNs.
  • In addition, blocking E2F-1 transcription protected cultured DNs against 1-methyl-4-phenylpyridinium toxicity.
  • Instead, our results demonstrate that mitosis-like signals are activated in mature DNs in patients with PD and mediate neuronal death in experimental models of the disease.

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  • (PMID = 17360686.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA077314-09; United States / NCI NIH HHS / CA / R01 CA077314; United States / NCI NIH HHS / CA / R01 CA077314-09; United States / NIMH NIH HHS / MH / R24 MH 68855; United States / NIMH NIH HHS / MH / R24 MH068855
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / E2F1 Transcription Factor; 0 / E2f1 protein, mouse; 0 / Oligonucleotides, Antisense; 9P21XSP91P / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; R865A5OY8J / 1-Methyl-4-phenylpyridinium
  • [Other-IDs] NLM/ PMC1805567
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24. Kim JI, Lee JM, Choi JY, Kim YK, Kim SH, Lee JY, Han JK, Choi BI: The value of gadobenate dimeglumine-enhanced delayed phase MR imaging for characterization of hepatocellular nodules in the cirrhotic liver. Invest Radiol; 2008 Mar;43(3):202-10
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  • OBJECTIVES: To evaluate the value of 1-hour delayed phase imaging (DPI) of gadobenate dimeglumine (Gd-BOPTA)-enhanced MR imaging for the characterization of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in patients with cirrhosis.
  • MATERIALS AND METHODS: A total of 37 patients with 42 HCCs and 13 DNs were included in this study and all lesions were histopathologically confirmed except for 15 HCCs.
  • RESULTS: In the qualitative analysis, among 42 HCCs, 30 (71.4%) were hypointense on DPI, and 10 (23.8%) and 2 (4.8%) were isointense and hyperintense, respectively; only 1 of 13 DNs (7.7%) was hypointense and 10 (76.9%) and 2 (15.4%) were isointense and hyperintense, respectively.
  • In the quantitative analysis, the mean CNR of the HCCs and the DNs on the 1-hour DPI was -6.32 +/- 6.27 and -0.07 +/- 3.28, respectively; the difference between the HCCs and the DNs was significant (P < 0.05).

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  • (PMID = 18301317.001).
  • [ISSN] 0020-9996
  • [Journal-full-title] Investigative radiology
  • [ISO-abbreviation] Invest Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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25. Kluger N, Thomas L: The dragon with atypical mole syndrome. Arch Dermatol; 2008 Jul;144(7):948-9
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  • [Title] The dragon with atypical mole syndrome.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis. Tattooing / adverse effects

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  • (PMID = 18645155.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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26. Hytiroglou P, Theise ND: Telomerase activation in human hepatocarcinogenesis. Am J Gastroenterol; 2006 Apr;101(4):839-41
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  • Active telomerase is present in the majority of malignant human tumors, including most cases of hepatocellular carcinoma (HCC).
  • Telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, has been found to be expressed in HCCs, dysplastic (precancerous) nodules (DNs), and regenerative nodules arising in cirrhosis.
  • High levels of hTERT mRNA were present in HCCs, high-grade DNs, and occasional low-grade DNs, whereas low levels were found in normal livers, livers with chronic hepatitis B (with or without cirrhosis), large regenerative nodules, and most low-grade DNs.
  • Indeed, emerging data from gene expression analyses of DNs and HCCs suggest that hTERT can be included in sets of select genes that provide "molecular signatures" with utility in the diagnosis and management of nodular hepatic lesions.

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  • [CommentOn] Am J Gastroenterol. 2006 Apr;101(4):831-8 [16494581.001]
  • (PMID = 16635228.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; EC 2.7.7.49 / Telomerase
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27. Xu H, Li X, Xie JX, Yang ZH, Wang B: Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model. Acad Radiol; 2007 Mar;14(3):279-86
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  • MATERIALS AND METHODS: Forty rats with chemically induced primary hepatic nodules ranging pathologically from regenerative nodules (RNs) to dysplastic nodules (DNs) to HCC were examined with diffusion-weighted imaging.
  • RESULTS: Eight RNs, 16 DNs, 7 well-differentiated HCCs (HCCwell), 11 moderately differentiated HCCs (HCCmod), and 14 poorly differentiated HCCs (HCCpoor) were evaluated.
  • There was no significant difference between RNs and DNs (P > 0.05).
  • Although the ADC values of HCCwell were slightly lower than those of DNs, there was no significant difference between them (P > 0.05).
  • CONCLUSION: Diffusion-weighted magnetic resonance imaging can be useful in characterizing focal hepatic nodular lesions, but ADC values cannot be used efficiently to distinguish HCCwell from DNs.

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  • (PMID = 17307660.001).
  • [ISSN] 1076-6332
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. Xu H, Kong X, Xiong Y, Zhang X: MR features of regenerative nodules and dysplastic nodules in the cirrhotic liver. J Huazhong Univ Sci Technolog Med Sci; 2005;25(5):601-3
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  • [Title] MR features of regenerative nodules and dysplastic nodules in the cirrhotic liver.
  • In order to study MR features of the regenerative nodule (RN) and dysplastic nodule (DN) of the cirrhotic liver, 26 cases of cirrhotic liver with RNs and DNs, of which 8 cases accompanied with hepatocellular carcinoma, were subjected to MRI.
  • Among the 14 cases of DNs, 8 cases had nodules measuring 1-3 cm in size and 6 had macroregenerative nodule measuring > 3 cm.
  • In 8 cases with DNs measuring 1-3 cm in size, 5 cases appeared hyperintense on T1WI and hypointense on T2WI as well as the enhancement as that of nodules with < 1 cm in size; and the remaining 3 cases appeared hypointense on T1WI and hyperintense on T2WI, and were not isointense to the surrounding hepatic parenchyma on enhanced MRI but hyperintense on SPIO enhanced MRI.
  • It was suggested that RNs of cirrhosis had features on MRI that usually allow distinction from hepatocellular carcinoma but not always from dysplastic nodules (DNs).
  • A helpful distinction between HCC and DNs is that the latter are almost never hyperintense on T2WI.
  • Additionally, low grade DNs appear hypointense on SPIO enhanced MRI.

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  • [Cites] AJR Am J Roentgenol. 1990 Dec;155(6):1227-31 [2122669.001]
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  • (PMID = 16463687.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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29. Hammer H, Tóth-Molnár E, Oláh J, Dobozy A: [Connection between uveal melanoma and dysplastic naevus syndrome]. Magy Onkol; 2005;49(1):15-8
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  • [Title] [Connection between uveal melanoma and dysplastic naevus syndrome].
  • [Transliterated title] Az uvealis melanoma és a dysplasticus naevus-syndroma kapcsolata.
  • The dysplastic naevus syndrome increases the risk of cutaneous (RR: 4.36; CI: 1.84-10.36) as well as uveal melanoma (RR: 4.22; CI: 1.81-9.84).
  • A significantly higher occurrence rate of conjunctival naevi (3.2% vs. 0%; p=0.029), choroidal naevi (5.2% vs. 0.7%; p=0.023) and iris freckles (17.1% vs. 5.6%; p=0.002) could be detected in the dysplastic naevus syndrome patients compared to subjects in the control group.
  • The presence of cutaneous dysplastic naevi in uveal melanoma patients increases the risk of the prognostically worse--epitheloid or mixed--forms of uveal melanoma (RR: 5.97%; CI: 1.61-22.14), compared to patients without cutaneous atypical naevi.
  • [MeSH-major] DNA, Neoplasm / analysis. Dysplastic Nevus Syndrome / genetics. Melanoma / genetics. Skin Neoplasms / genetics. Uveal Neoplasms / genetics


30. Shpak AV, Pirogov AV, Shpigun OA: The selectivity in MEKC of pseudo-stationary phases based on polyelectrolyte complexes: I. Composition of the complex. Anal Bioanal Chem; 2005 May;382(2):504-12
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  • In this paper, the effect of the composition (phi) of the PSC of polyacrylic acid (PAA) M(W) 130,000 with dodecyltrimethylammonium bromide (DTAB) and of the PSC of PAA M(W) 450,000 with DTAB on the separation of DNS-amino acids and phenol derivatives in these systems was investigated.

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  • (PMID = 15895212.001).
  • [ISSN] 1618-2642
  • [Journal-full-title] Analytical and bioanalytical chemistry
  • [ISO-abbreviation] Anal Bioanal Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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31. Wang C, Wang R, Wang D, Ding G, Jiang Z: [The investigation about the influence of deviated nasal septum on the adolescents learning quality]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Oct;24(20):937-9
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  • OBJECTIVE: To investigate the incidence rate of deviated nasal septum (DNS) of the young men who are going to join the army, and of the students in key high schools in Jimo, and record their educational background, then analysis the influence of DNS on the youth's learning quality.
  • Investigate the two groups' incidence rate of DNS and make a correlative statistic analyses with their educational background.
  • RESULT: There are 395 young men with DNS, which account 12.8% of the 3085 men, with the educational background of college degree and above account 3.0%; high school diploma 12.4%; junior secondary education 27.5%.
  • One hundred and ninety-four students with DNS in key high schools, which account 7.4, and the subsequent entrance examination results shows, undergraduate students account 14.9%, junior college students and considerable education 32.5%, and graduates 52.6%.
  • CONCLUSION: DNS can influence the learning quality of the adolescent.

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  • (PMID = 21171301.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Wang L: Scaling of the two-point velocity difference along scalar gradient trajectories in fluid turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2009 Apr;79(4 Pt 2):046325
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  • This paper attempts to provide a theoretical basis for this finding by analyzing two-point properties along the gradient trajectories, of which dissipation elements consist.
  • Results from direct numerical simulation (DNS) show satisfactory agreement with the theoretical prediction.

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  • (PMID = 19518351.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. Hébert F, Hufschmid R, Scheel J, Ahlers G: Onset of Rayleigh-Bénard convection in cylindrical containers. Phys Rev E Stat Nonlin Soft Matter Phys; 2010 Apr;81(4 Pt 2):046318
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  • We determined the critical Rayleigh numbers Ra{c} for the onset of convection in cylindrical containers with aspect ratios 1 approximately <Gamma [ triple bond] D/L approximately <9 ( D is the diameter and L the height) and the patterns that form just above Ra{c}, both from experiment and by direct numerical simulation (DNS).
  • Our patterns agree with several DNS investigations by others, but at some Gamma values differ from those observed experimentally by Stork and Müller.

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  • (PMID = 20481838.001).
  • [ISSN] 1550-2376
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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34. Yoshii T, Heshiki Y, Ibuki-Ishibashi T, Matsumoto A, Tanimura T, Tomioka K: Temperature cycles drive Drosophila circadian oscillation in constant light that otherwise induces behavioural arrhythmicity. Eur J Neurosci; 2005 Sep;22(5):1176-84
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  • PER was also cyclically expressed under the temperature cycle in the known per-expressing neurons, i.e. so-called lateral (LNs) and dorsal neurons (DNs), and two pairs of cells (LPNs) that were located in the lateral posterior protocerebrum.
  • These behavioural results suggest that not only LNs but also DNs and LPNs can, at least, partially participate in regulating the thermoperiodically induced rhythm.

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  • (PMID = 16176360.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Drosophila Proteins; 0 / Nuclear Proteins; 0 / PER protein, Drosophila; 0 / Period Circadian Proteins; 0 / timeless protein, Drosophila
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35. Messina A, Moroni S, Flieger M, Sinibaldi M, Ursini O: CEC enantioseparations of carboxylic acids on silica-based monoliths modified with ergot alkaloid derivative. Electrophoresis; 2009 Aug;30(16):2890-6
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  • For example, on the monolithic column Dns-serine enantiomers were much better separated (8 min with a selectivity factor of 1.34) than by HPLC (20 min, alpha=1.17);.

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  • (PMID = 19691053.001).
  • [ISSN] 1522-2683
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Carboxylic Acids; 0 / Dansyl Compounds; 0 / Ergot Alkaloids; 7631-86-9 / Silicon Dioxide
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36. Kim SH, Lim HK, Kim MJ, Choi D, Rhim H, Park CK: Radiofrequency ablation of high-grade dysplastic nodules in chronic liver disease: comparison with well-differentiated hepatocellular carcinoma based on long-term results. Eur Radiol; 2008 Apr;18(4):814-21
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  • [Title] Radiofrequency ablation of high-grade dysplastic nodules in chronic liver disease: comparison with well-differentiated hepatocellular carcinoma based on long-term results.
  • This retrospective study compared the long-term results of percutaneous radiofrequency (RF) ablation for high-grade dysplastic nodules (DNs) and well-differentiated hepatocellular carcinomas (HCCs).
  • Between April 1999 and December 2006, 20 patients with 21 high-grade DNs (range, 1.2-3.0 cm; mean, 1.9 cm) (group 1) and 49 with a well-differentiated HCC (range, 1.0-5.0 cm; mean, 2.3 cm) (group 2) underwent RF ablation.
  • Percutaneous RF ablation is effective for treating high-grade DNs and well-differentiated HCCs.
  • The long-term results after RF ablation of high-grade DNs may be improved compared with those of well-differentiated HCCs.
  • [MeSH-minor] Adult. Aged. Biopsy. Chronic Disease. Contrast Media. Female. Humans. Male. Middle Aged. Retrospective Studies. Statistics, Nonparametric. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18080127.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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37. Maász A, Horvatovich K, Magyari L, Talián Csaba G, Bokor S, Laczy B, Tamaskó M, Molnár D, Wittmann I, Melegh B: [Search for mitochondrial DNA T4291C mutation in Hungarian patients with metabolic syndrome]. Orv Hetil; 2006 Apr 16;147(15):693-6
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  • [Title] [Search for mitochondrial DNA T4291C mutation in Hungarian patients with metabolic syndrome].
  • [Transliterated title] Mitokondriális DNS T4291C mutáció vizsgálata metabolikus szindrómában szenvedo betegekben.
  • INTRODUCTION: Metabolic syndrome affects 15-30 percentage of the population.
  • AIMS: In a recent study metabolic syndrome was shown to be transmitted on maternal lineage in a large family; an uridine to cytidine transition was detected in homoplasmic form at position 4291 of the mitochondrial DNA (mtDNA) which affects the 5' neighboring nucleotide to the anticodon of the isoleucine-tRNA.
  • METHODS: Using specific restriction analysis and direct sequencing for detection of this mutation the authors genotyped 365 DNA samples which were collected from 164 adult and 119 pediatric patients with metabolic syndrome.
  • RESULTS AND CONCLUSIONS: The T4291C mtDNA variant could not be detected in any of these patients suggesting that this alteration is likely rare in the Hungarian metabolic syndrome population.
  • [MeSH-major] DNA, Mitochondrial / genetics. Metabolic Syndrome X / genetics. Point Mutation

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  • (PMID = 16734181.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / RNA, Transfer, Ile; 2ZD004190S / Threonine; K848JZ4886 / Cysteine
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38. Yoshida K, Yamaguchi J, Kaneda Y: Regeneration of small eddies by data assimilation in turbulence. Phys Rev Lett; 2005 Jan 14;94(1):014501
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  • [Title] Regeneration of small eddies by data assimilation in turbulence.
  • The effect of data assimilation of large-scale eddies on small-scale eddies in turbulence is studied by direct numerical simulations (DNSs) of Navier-Stokes turbulence with Taylor microscale Reynolds numbers up to 179.
  • The DNSs show that even if the data of small-scale eddies are lost at some initial instant, they can be regenerated from the data of large-scale eddies under the condition that Fourier modes with wave number less than a critical wave number k(*) are continuously assimilated, where k(*) approximately 0.2eta(-1) with eta identical with(nu(3)/epsilon)(1/4), epsilon the mean energy dissipation rate, and nu the viscosity.

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  • (PMID = 15698086.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Naso A, Pumir A: Scale dependence of the coarse-grained velocity derivative tensor structure in turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2005 Nov;72(5 Pt 2):056318
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  • Semiclassical solutions of this model are obtained and compared with direct numerical simulations (DNS) data.
  • The DNS data show that the joint probability distribution function of the second and third invariants of M becomes increasingly skewed as the scale r decreases in the inertial range.

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  • (PMID = 16383756.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Kao LW, Nañagas KA: Carbon monoxide poisoning. Med Clin North Am; 2005 Nov;89(6):1161-94
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  • HBOT accelerates dissociation of CO from hemoglobin and may also prevent DNS.

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  • (PMID = 16227059.001).
  • [ISSN] 0025-7125
  • [Journal-full-title] The Medical clinics of North America
  • [ISO-abbreviation] Med. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 254
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41. Herrgott I, Riemekasten G, Hunzelmann N, Sunderkötter C: Management of cutaneous vascular complications in systemic scleroderma: experience from the German network. Rheumatol Int; 2008 Aug;28(10):1023-9
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  • Even though SSc is a rare disease, timely and appropriate management of its vascular complications is mandatory for reducing the rate of major impairment.
  • [MeSH-major] Health Care Surveys. Raynaud Disease / drug therapy. Raynaud Disease / etiology. Scleroderma, Systemic / complications. Scleroderma, Systemic / drug therapy. Skin / blood supply

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  • (PMID = 18320192.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Calcium Channel Blockers; 0 / Prostaglandins I; 0 / Vasodilator Agents
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42. Hunzelmann N, Genth E, Krieg T, Meurer M, Melchers I, Moinzadeh P, Pfeiffer C, Riemekasten G, Schulze-Lohoff E, Sunderkoetter C, Müller-Ladner U, German Network for Systemic Sclerosis: [Organ-specific diagnosis in patients with systemic sclerosis: Recommendations of the German Network for Systemic Sclerosis (DNSS)]. Z Rheumatol; 2008 Jul;67(4):334-6, 337-40
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  • The diagnosis and therapy of systemic sclerosis (SSc) is demanding due to its nature as a multisystem disease and its chronic, severe course.
  • To date, there are no generally accepted recommendations for diagnostic work-up either for the time of initial disease diagnosis or for the regular follow-up clinical examinations and diagnostic procedures required.

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  • (PMID = 18418613.001).
  • [ISSN] 0340-1855
  • [Journal-full-title] Zeitschrift fur Rheumatologie
  • [ISO-abbreviation] Z Rheumatol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Practice Guideline
  • [Publication-country] Germany
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43. Bos E, Löfmark A, Törnkvist L: District nurses' experience of supervising nursing students in primary health care: A pre- and post-implementation questionnaire study. Nurse Educ Pract; 2009 Nov;9(6):361-6
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  • Nursing students go through clinical supervision in primary health care settings but district nurses' (DNs) circumstances when supervising them are only briefly described in the literature.
  • The aim of this study was to investigate DNs experience of supervising nursing students before and after the implementation of a new supervision model.
  • Ninety-eight (74%) DNs answered a questionnaire before and 84 (65%) after implementation of the new supervision model.
  • The study showed that DNs in most cases felt that conditions for supervision in the workplace were adequate.
  • Improvements after the implementation of a new model chiefly concerned organisation; more DNs stated that one person had primary responsibility for students' clinical practice, that information packages for supervisors and students were available at the health care centres, and that conditions were in place for increasing the number of students they supervised.
  • DNs also stated that supervisors and students benefited from supervision by more than one supervisor.

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  • (PMID = 19042155.001).
  • [ISSN] 1873-5223
  • [Journal-full-title] Nurse education in practice
  • [ISO-abbreviation] Nurse Educ Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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44. Pastar Z, Lipozencić J, Kovacević S, Canović S, Didović-Torbarina A, Vukasović A: Neurofibromatosis type 1 associated with dysplastic nevus syndrome. Acta Dermatovenerol Croat; 2009;17(2):118-22
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  • [Title] Neurofibromatosis type 1 associated with dysplastic nevus syndrome.
  • Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder that primarily affects the development and growth of neural cell tissues.
  • Dysplastic nevus syndrome (DNS) represents multiple atypical nevi associated with polygenetic inheritance pattern and may rarely occur together with NF-1.
  • DNS type A is a marker of increased melanoma risk, while melanoma has been rarely reported in patients with NF-1.
  • We describe a case of NF-1 type A with DNS presenting with multiple neural tumors, cafe-au-lait spots, hamartomas in globus pallidus and pigmented melanocytic iris hamartomas (Lisch nodules).
  • The importance of close follow up of nevi in such patients with NF-1 and DNS for the development of melanoma as well as other NF-1 associated skin disorders and with multidisciplinary approach to other associated diseases is highlighted.
  • [MeSH-major] Dysplastic Nevus Syndrome / complications. Neurofibromatosis 1 / complications


45. Griffith R, Tengnah C: The law and grievance resolution in the workplace: a guide for DNs. Br J Community Nurs; 2009 May;14(5):213-6
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  • [Title] The law and grievance resolution in the workplace: a guide for DNs.

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  • (PMID = 19421087.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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46. Kojiro M, Roskams T: Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis; 2005;25(2):133-42
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  • [Title] Early hepatocellular carcinoma and dysplastic nodules.
  • It has been established that small, equivocal nodular lesions such as dysplastic nodules (DNs) and small well-differentiated hepatocellular carcinomas (early HCCs) are frequently observed in noncancerous liver tissues resected along with HCCs and in explant cirrhotic livers.
  • DNs are classified into low-grade DNs or high-grade DNs on the basis of cytological and architectural atypia; high-grade DNs show varying degrees of cytological or architectural atypia, or both.
  • Early HCCs are indistinctly nodular and highly differentiated and are frequently difficult to differentiate from high-grade DNs.
  • Although the pathological diagnosis of high-grade DNs and early HCCs is controversial, the presence of tumor cell invasion into the intratumoral portal tracts (stromal invasion) is a helpful clue for differentiating early HCC from high-grade DNs.
  • It is highly suggested that many HCCs occurring in cirrhotic liver arise in DNs and develop to classical HCC in a multistep fashion.
  • [MeSH-minor] Cell Aging. Cell Differentiation. Disease Progression. Hepatocytes / pathology. Humans. Immunohistochemistry. Liver Cirrhosis / pathology. Neoplasm Invasiveness

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  • (PMID = 15918142.001).
  • [ISSN] 0272-8087
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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47. Arumi-Uria M: Dysplastic nevus: the eye of the hurricane. J Cutan Pathol; 2008 Nov;35 Suppl 2:16-9
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  • [Title] Dysplastic nevus: the eye of the hurricane.
  • Dysplastic nevi were generally recognized, thanks to the contributions of Clark et al. in 1978.
  • These lesions were described in a familial context, which was called the 'B-K mole syndrome'.
  • However, it is worth noting that this was not the first time that these nevi had been described in the literature.
  • If we look back in history, we can find that in 1820, Norris had already described some very similarly pigmented lesions, also in a familial context, just as Cawley subsequently did in 1952.
  • Clark coined the term of dysplastic nevi for lesions presenting in patients with personal and family histories of malignant melanoma, having from 10 to 100 nevus lesions of a certain size, irregular shape and variable pigmentation of more than 5 mm.
  • In addition, he pointed out that histologically, such lesions were principally characterized by the presence of atypical melanocytic hyperplasia.
  • [MeSH-major] Dysplastic Nevus Syndrome / epidemiology. Dysplastic Nevus Syndrome / history. Dysplastic Nevus Syndrome / pathology

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  • (PMID = 18976414.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 29
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48. Kennedy C: District nursing support for patients with cancer requiring palliative care. Br J Community Nurs; 2005 Dec;10(12):566, 568-72, 574
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  • Patients with cancer spend the majority of the last year of life at home, with district nurses (DNs) as the main care coordinators and providers.
  • The sample was three DNs and the principal data collection methods were episodes of participant observation (n=11) and in-depth interviews (n=12).

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  • (PMID = 16415735.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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49. Asad A, Hameed MA, Khan UA, Ahmed N, Butt MU: Reliability of the neurological scores for assessment of sensorimotor neuropathy in type 2 diabetics. J Pak Med Assoc; 2010 Mar;60(3):166-70
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  • RESULTS: Taking the NCS as gold standard DNS, DNE, NSS and NDS had 64.1%, 17.95%, 82.05%, 92.31% sensitivity and 80.95%, 100%, 66.67%, 47.62% specificity, respectively.
  • Diagnostic efficacy of DNS was 70%, DNE was 47%, NSS was 77% and NDS was 77%.
  • [MeSH-minor] Adult. Cross-Sectional Studies. Disease Progression. Female. Health Status Indicators. Humans. Male. Middle Aged. Neural Conduction. Neurologic Examination. Predictive Value of Tests. Reproducibility of Results. Sensitivity and Specificity. Surveys and Questionnaires

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  • (PMID = 20225769.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Validation Studies
  • [Publication-country] Pakistan
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50. Shen J, Cao Y, Han YJ, Luo XR, Xie CH, Li JM, Xue YM: [Sweat function evaluation for early diagnosis of diabetic peripheral neuropathy]. Nan Fang Yi Ke Da Xue Xue Bao; 2007 Aug;27(8):1210-2
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  • METHODS: Ninety-eight hospitalized type 2 diabetic patients with or without DPN (DN and DC groups) according to Michigan Diabetic Neruopathy Score (DNS) and 40 healthy volunteers (NC group) were evaluated for their sweat function of the feet in relation to the peripheral autonomic nerve with sweat printing method using Neuropad.
  • The Neuropad color-changing time was recorded to assess the sensitivity and specificity of sweat printing methods relative to DNS for DNP evaluation, and the correlation of the Neuropad color-changing time to DNS score was analyzed.
  • The morbidity rate detected by sweat printing method was 62.2%, similar to that detected by DNS (57.1%, P>0.05).
  • DNS showed significant positive correlation with the Neuropad color-changing time (r=0.46, P<0.05).

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  • (PMID = 17715028.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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51. Bhattacharjee A, Uddin S, Purkaystha P: Deviated nasal septum in the newborn-A 1-year study. Indian J Otolaryngol Head Neck Surg; 2005 Oct;57(4):304-8
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  • It was found that high-birth weight babies, delivered by vaginal route (55%), to a primi mother are more likely to have DNS after birth.
  • Moreover, intrauterine malposition particularly breech (45%) and prolonged labour seemed to play a role in newborn DNS.

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  • (PMID = 23120201.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451441
  • [Keywords] NOTNLM ; Deviated nasal septum / newborn
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52. Goto S, Osborne DR, Vassilicos JC, Haigh JD: Acceleration statistics as measures of statistical persistence of streamlines in isotropic turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2005 Jan;71(1 Pt 2):015301
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  • Using theoretical arguments, direct numerical simulations (DNS), and kinematic simulations (KS) of three-dimensional isotropic turbulence for different ratios of inner to outer length scales L/eta of the self-similar range, we show that a frame exists where the average Vs = 0 , that the rms values of acceleration, turbulent fluid velocity, and Vs are related by La'/u'2 approximately (V's/u')(L/eta)(2/3+q) , and that V's/u' approximately (L/eta)q with q = -1/3 in Kolmogorov turbulence, q = -1/6 in current DNS, and q = 0 in our KS.

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  • (PMID = 15697648.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Shah SA, Sajid T, Asif M, Khan F, Haroon T, Malik S, Ghani R: Evaluation of efficacy of management protocol in allergic rhinitis. J Ayub Med Coll Abbottabad; 2007 Jul-Sep;19(3):6-9
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  • 37.53% patients had surgery done for associated pathologies, mostly a DNS.

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  • (PMID = 18444581.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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54. Sato K, Kanno J, Tominaga T, Matsubara Y, Kure S: De novo and salvage pathways of DNA synthesis in primary cultured neurall stem cells. Brain Res; 2006 Feb 3;1071(1):24-33
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  • [Title] De novo and salvage pathways of DNA synthesis in primary cultured neurall stem cells.
  • We studied the de novo and salvage pathways of DNA synthesis in sphere-forming neural stem cells obtained from mouse embryos by a neurosphere method.
  • The former pathway needs folic acid (FA) for nucleotide biosynthesis, while the latter requires deoxyribonucleosides (dNS).
  • We examined the proliferative activity of sphere-forming cells in E14.5 embryos by counting the number of spheres formed in media that lacked FA and/or dNS.
  • Proliferation failure and apoptosis occurred in a deficient medium lacking of both FA and dNS.
  • Spheres formed in the deficient medium supplemented with dNS, without FA, did not produce neuron, but rather only seem to generate astrocytes and oligodendrocytes when plated under differentiation condition in culture.
  • Spheres formed in the media containing low dose Azathioprine and methotrexate, inhibitors of de novo DNA synthesis, were selectively prevented from producing neurons even in the presence of FA.
  • These results suggested that activating de novo DNA synthesis was needed for neural stem cells to proliferate with multipotentiality.

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  • (PMID = 16409993.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antimetabolites; 0 / Deoxyribonucleosides; 0 / Enzyme Inhibitors; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / Mtap2 protein, mouse; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / O Antigens; 0 / Tubulin; 0 / beta3 tubulin, mouse; 12001-76-2 / Vitamin B Complex; 9007-49-2 / DNA; 935E97BOY8 / Folic Acid; MRK240IY2L / Azathioprine; YL5FZ2Y5U1 / Methotrexate
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55. Oh BK, Kim YJ, Park C, Park YN: Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am J Pathol; 2005 Jan;166(1):73-80
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  • The transcriptional expression of these genes, TRF1 protein, and telomere length was examined in 9 normal livers, 14 chronic hepatitis, 24 liver cirrhosis, 5 large regenerative nodules, 14 low-grade dysplastic nodules (DNs), 7 high-grade DNs, 10 DNs with hepatocellular carcinoma (HCC) foci, and 31 HCCs.
  • The expression of TRF1, TRF2, TIN2 mRNA, and TRF1 protein was gradually increased according to the progression of hepatocarcinogenesis with a marked increase in high-grade DNs and DNs with HCC foci and a further increase in HCCs.
  • There was a gradual shortening of telomere during hepatocarcinogenesis with a significant reduction in length in DNs.
  • This was more evident in DNs and DNs with HCC foci.

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  • (PMID = 15632001.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Complementary; 0 / TINF2 protein, human; 0 / Telomere-Binding Proteins; 0 / Telomeric Repeat Binding Protein 1; 0 / Telomeric Repeat Binding Protein 2
  • [Other-IDs] NLM/ PMC1602303
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56. Huang M, Chen T, Chan Z: An evaluation for cross-species proteomics research by publicly available expressed sequence tag database search using tandem mass spectral data. Rapid Commun Mass Spectrom; 2006;20(18):2635-40
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  • It was confirmed that the former could identify more peptides manually validated by de novo sequencing (DNS) from fewer species in more closely phylogenetic relationships than the latter in a statistically significant manner.

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  • [Copyright] Copyright 2006 John Wiley & Sons, Ltd.
  • (PMID = 16941525.001).
  • [ISSN] 0951-4198
  • [Journal-full-title] Rapid communications in mass spectrometry : RCM
  • [ISO-abbreviation] Rapid Commun. Mass Spectrom.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Proteins
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57. Philip G, Williams-Herman D, Patel P, Weinstein SF, Alon A, Gilles L, Tozzi CA, Dass SB, Reiss TF: Efficacy of montelukast for treating perennial allergic rhinitis. Allergy Asthma Proc; 2007 May-Jun;28(3):296-304
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  • [Title] Efficacy of montelukast for treating perennial allergic rhinitis.
  • Perennial allergic rhinitis (PAR) is a chronic inflammatory nasal condition in individuals exposed year-round to allergens.
  • This was a double-blind study of 15- to 85-year-old patients randomly allocated to montelukast, 10 mg (n=630), placebo (n=613), or the positive control cetirizine, 10 mg (n=122) for 6 weeks.
  • The primary efficacy end point was change from baseline in Daytime Nasal Symptoms Score (DNSS; mean of congestion, rhinorrhea, sneezing, and itching scores, rated daily by patients [scale: 0=none to 3=severe]) averaged during the initial 4 weeks (primary analysis) or entire 6 weeks of treatment.
  • Also assessed were combined post hoc results of primary end point data from this study and another similarly designed study (Patel P, et al. Randomized, double-blind, placebo-controlled study of montelukast for treating perennial allergic rhinitis, Ann Allergy Asthma Immunol 95:551, 2005).
  • Over 4 weeks, montelukast showed numerical improvement over placebo in DNSS (least-squares mean difference of -0.04 [95% confidence interval (CI}, -0.09, 0.01]); the difference between cetirizine and placebo was significant: -0.10 (95% CI, -0.19, -0.01).
  • However, when averaged over 6 weeks, neither active treatment was significantly different from placebo.
  • The Rhinoconjunctivitis Quality-of-Life score was significantly improved by montelukast (p < 0.05), but not by cetirizine, during 4 and 6 weeks.
  • The treatment effect of montelukast, but not cetirizine, generally remained consistent through the 6 weeks of treatment.
  • In pooled data, montelukast consistently improved DNSS versus placebo during all 6 weeks of treatment (-0.07 [95% CI, -0.10, -0.041).
  • In conclusion, montelukast produced numerical improvement in daytime nasal symptoms and significant improvement in quality of life.
  • In a pooled post hoc analysis, montelukast provided consistent improvement in daytime nasal symptoms over 6 weeks, supportive of an overall benefit in PAR.

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  • (PMID = 17619558.001).
  • [ISSN] 1088-5412
  • [Journal-full-title] Allergy and asthma proceedings
  • [ISO-abbreviation] Allergy Asthma Proc
  • [Language] ENG
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetates; 0 / Leukotriene Antagonists; 0 / Nasal Decongestants; 0 / Quinolines; MHM278SD3E / montelukast; YO7261ME24 / Cetirizine
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58. Disler R, Jones A: District nurse role in end-stage COPD: a review. Br J Community Nurs; 2010 Sep;15(9):428-30, 432-33
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  • District Nurses (DNs) are core providers of end-stage care in the community but appear to have little contact with patients suffering from non-malignant diseases, such as chronic obstructive pulmonary disease (COPD).
  • This review found limited literature describing the role of DNs in end-stage COPD care, and the studies that did touch on the subject restricted their discourse to the frequency of interaction.
  • A clear bias of end-of-life services to patients with malignancy was noted, as well as a call for community services to extend care to all end-stage patients regardless of underlying disease.
  • In addition, there was a further call for DNs to apply a more holistic approach to care, as described in the literature.
  • Finally, it was clear that while ongoing community intervention is necessary for end-stage COPD patients, support and training is essential to equip DNs to care for these vulnerable patients.
  • [MeSH-major] Nurse's Role. Public Health Nursing / organization & administration. Pulmonary Disease, Chronic Obstructive / nursing. Terminal Care / organization & administration

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  • (PMID = 20852523.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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59. Hutchins N, Marusic I: Large-scale influences in near-wall turbulence. Philos Trans A Math Phys Eng Sci; 2007 Mar 15;365(1852):647-64
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  • Reassessment of DNS data, in light of these results, shows similar trends, with the rate and intensity of production due to the near-wall cycle subject to a modulating influence from the largest-scale motions.

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  • (PMID = 17244584.001).
  • [ISSN] 1364-503X
  • [Journal-full-title] Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
  • [ISO-abbreviation] Philos Trans A Math Phys Eng Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. Chuang KH, Cheng CM, Roffler SR, Lu YL, Lin SR, Wang JY, Tzou WS, Su YC, Chen BM, Cheng TL: Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines. Bioconjug Chem; 2006 May-Jun;17(3):707-14
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  • In the current study, we examined whether multiple therapeutic agents could be targeted to anti-dansyl single-chain antibodies (DNS scFv) that were anchored on the plasma membrane of cancer cells.
  • Functional DNS scFv could be stably expressed on CT-26 colon cancer cells both in vitro and in vivo.
  • Dansyl moieties were covalently attached to recombinant beta-glucuronidase (betaG) and interleukin 2 (IL-2) via a flexible poly(ethylene glycol) linker to form DNS-PEG-betaG and DNS-PEG-IL-2 conjugates.
  • The conjugates selectively bound CT-26 cells that expressed anti-DNS scFv (CT-26/DNS cells) but not CT-26 cells that expressed control scFv (CT-26/phOx cells).
  • DNS-PEG-betaG preferentially activated a glucuronide prodrug (BHAMG) of p-hydroxy aniline mustard at CT-26/DNS cells in culture and accumulated in subcutaneous CT-26/DNS tumors after intravenous administration.
  • Systemic administration of DNS-PEG-IL-2 or DNS-PEG-betaG and BHAMG significantly delayed the growth of CT-26/DNS but not control CT-26/phOx tumors.
  • Combination treatment with DNS-PEG-betaG and BHAMG followed by DNS-PEG-IL-2 therapy significantly suppressed the growth of CT-26/DNS tumors as compared to either single-agent regimen.
  • These results show that at least two DNS-modified therapeutic agents can be selectively delivered to DNS scFv receptors in vitro and in vivo, allowing combination therapy of DNS scFv-modified tumors.

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  • (PMID = 16704208.001).
  • [ISSN] 1043-1802
  • [Journal-full-title] Bioconjugate chemistry
  • [ISO-abbreviation] Bioconjug. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antineoplastic Agents; 0 / Haptens; 0 / Interleukin-2; 0 / Prodrugs; 30IQX730WE / Polyethylene Glycols; EC 3.2.1.31 / Glucuronidase
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61. Taswell C: DOORS to the semantic web and grid with a PORTAL for biomedical computing. IEEE Trans Inf Technol Biomed; 2008 Mar;12(2):191-204
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  • The domain name system (DNS), web browsers, and the benefits of publishing web pages motivated many people to register domain names and publish web sites on the original web.
  • The Internet Registry Information Service (IRIS) registers [corrected] domain names while DNS publishes domain addresses with mapping of names to addresses for the original web.

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  • [ErratumIn] IEEE Trans Inf Technol Biomed. 2008 May;12(3):411
  • (PMID = 18348949.001).
  • [ISSN] 1089-7771
  • [Journal-full-title] IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society
  • [ISO-abbreviation] IEEE Trans Inf Technol Biomed
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 106
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62. Müller-Ladner U: [Systemic sclerosis]. Internist (Berl); 2008 Mar;49(3):278-85
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  • No specific predictive markers for the disease exist in the early phases of the disease although a Raynaud phenomenon can be present up to ten years prior to the first organ manifestations.
  • Therefore, monitoring should be performed on a regular basis in the preclinical and early stages of the disease, as early diagnosis can reduce morbidity and mortality of the affected patients significantly, especially with regard to pulmonary hypertension, digital ischemia, reflux esophagitis and sclerodermal renal crisis.

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  • [Cites] Rheumatology (Oxford). 2004 Jun;43(6):719-26 [15026581.001]
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  • (PMID = 18210018.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 12
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63. Chou CT, Chen YL, Su WW, Wu HK, Chen RC: Characterization of cirrhotic nodules with gadoxetic acid-enhanced magnetic resonance imaging: the efficacy of hepatocyte-phase imaging. J Magn Reson Imaging; 2010 Oct;32(4):895-902
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  • The histological examination revealed 15 dysplastic nodules (DNs), 7 well-differentiated hepatocellular carcinomas (wHCCs), and 44 moderately differentiated HCCs (mHCCs).
  • The mean ERs of DNs were increased in dynamic study and hepatocyte phase.
  • DNs showed no significant difference in any phase (P > 0.05).

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  • (PMID = 20882620.001).
  • [ISSN] 1522-2586
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
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64. Thurtle V: Why do nurses enter community and public health practice? Community Pract; 2005 Apr;78(4):140-5
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  • This paper reports the findings of a survey of community specialist practice students--community children's nurses (CCNs), community mental health nurses (CMHNs) district nurses (DNs), health visitors (HVs), practice nurses (PNs), school nurses (SNs)--in a large London based programme.

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  • (PMID = 15875602.001).
  • [ISSN] 1462-2815
  • [Journal-full-title] Community practitioner : the journal of the Community Practitioners' & Health Visitors' Association
  • [ISO-abbreviation] Community Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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65. Streltsov SA, Beabealashvili RSh, Grechishnikov SB: Thr-Val-Thr dansyl hydrazide: the first fluorescent tripeptide preferentially binding with at pairs in DNA. J Biomol Struct Dyn; 2005 Dec;23(3):347-56
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  • Here we test our assumptions with a specially designed tripeptide L-Thr-L-Val-L-Thr-NH-NH-Dns (Dns is 5-dimethylaminonaphthalene-1-sulfonic acid residue).
  • The peptide dimers clearly prefer the AT pairs [half-saturating peptide concentrations are (0.6-0.7) x 10(-4) M for poly(dA).poly(dT) but exceed (2.5-2.8) x10(-4) M for poly(dG).poly(dC)].
  • Since Dns-tagged trivaline has been shown to prefer the GC pairs, we think it now becomes possible to design oligopeptides that would specifically bind to any predefined nucleotide sequence.
  • [MeSH-major] DNA / chemistry. Dansyl Compounds. Fluorescent Dyes. Hydrazines. Nucleic Acid Conformation. Peptides. Poly dA-dT / metabolism

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  • (PMID = 16218759.001).
  • [ISSN] 0739-1102
  • [Journal-full-title] Journal of biomolecular structure & dynamics
  • [ISO-abbreviation] J. Biomol. Struct. Dyn.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dansyl Compounds; 0 / Fluorescent Dyes; 0 / Hydrazines; 0 / Peptides; 26966-61-0 / Poly dA-dT; 33008-06-9 / dansyl hydrazine; 9007-49-2 / DNA
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66. Peng W, Chen Y, Fan S, Zhang F, Zhang G, Fan X: Use of 4,4'-dinitrostilbene-2,2'-disulfonic acid wastewater as a raw material for paramycin production. Environ Sci Technol; 2010 Dec 1;44(23):9157-62
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  • This study uses 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNS) wastewater to produce paramycin (4-amino-2-hydroxybenzoic acid), an antitubercular agent and important pharmaceutical intermediate.
  • The high concentrations of aromatic sulfonic acids contained in the wastewater, derived from a DNS production facility, have been transformed to paramycin in yields of more than 85%.
  • This waste-disposal strategy, which combines oxidation using NaClO, reduction using iron powder, and subsequent alkaline fusion with NaOH, has been proven to be successful in dealing with ton-scale DNS wastewater.
  • This effectively solves the associated environment problems associated with DNS wastewater and is also potentially profitable.

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  • (PMID = 21053909.001).
  • [ISSN] 1520-5851
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Stilbenes; 0 / Water Pollutants, Chemical; 128-42-7 / 4,4'-dinitro-2,2'-stilbenedisulfonic acid; 5B2658E0N2 / Aminosalicylic Acid
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67. Tonan T, Fujimoto K, Azuma S, Ono N, Matsushita S, Kojiro M, Hayabuchi N: Evaluation of small (&lt;or=2 cm) dysplastic nodules and well-differentiated hepatocellular carcinomas with ferucarbotran-enhanced MRI in a 1.0-T MRI unit: utility of T2*-weighted gradient echo sequences with an intermediate-echo time. Eur J Radiol; 2007 Oct;64(1):133-9
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  • [Title] Evaluation of small (<or=2 cm) dysplastic nodules and well-differentiated hepatocellular carcinomas with ferucarbotran-enhanced MRI in a 1.0-T MRI unit: utility of T2*-weighted gradient echo sequences with an intermediate-echo time.
  • PURPOSE: To evaluate the detectability and signal intensities of small (<or=2 cm) dysplastic nodules (DNs) and well-differentiated hepatocellular carcinomas (w-HCCs) by T2*-weighted gradient echo (GRE) sequences using an intermediate echo-time (TE) with ferucarbotran in a 1.0-T magnetic resonance imaging (MRI) unit.
  • MATERIALS AND METHODS: Pathologically confirmed DNs (n=13) and w-HCCs (n=31) with a median largest dimension of 1.1cm were scanned using ferucarbotran-enhanced MRI.
  • Qualitative and quantitative analyses indicated that specific-T2*GRE sequences were superior to conventional-T2*-GRE sequences for detecting DNs and w-HCCs with hypointense signals.
  • The tumor-liver-CNR of DNs was significantly different between specific-T2*-GRE sequences and conventional-T2*-GRE sequences (Mann-Whitney test, P<0.001).
  • CONCLUSION: Specific-T2*-GRE sequences with ferucarbotran are useful for detecting DNs and w-HCCs that produce hypointense signals on a 1.0-T MRI unit.

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  • (PMID = 17408900.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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68. Hatanpaa KJ, Bigio EH, Cairns NJ, Womack KB, Weintraub S, Morris JC, Foong C, Xiao G, Hladik C, Mantanona TY, White CL 3rd: TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study. J Neuropathol Exp Neurol; 2008 Apr;67(4):271-9
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  • Marked enhancement of staining of TDP-43-positive dystrophic neurites (DNs) was obtained, and we observed 2 previously unrecognized pathologic patterns (i.e. frequent long DNs in the CA1 region and frequent dot-like DNs in the neocortical layer 2) in 39% and 15% of the FTLD-U cases, respectively.
  • Frequent long DNs, but not dot-like DNs, were significantly associated with progranulin mutations.

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  • (PMID = 18379440.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / P30 AG013854; United States / NIA NIH HHS / AG / P01-AG03991; United States / NIA NIH HHS / AG / AG012300-159002; United States / NIA NIH HHS / AG / AG12300; United States / NIA NIH HHS / AG / P30 AG012300-159002; United States / NIA NIH HHS / AG / U01 AG016976; United States / NIA NIH HHS / AG / P01 AG003991; United States / NIA NIH HHS / AG / P50 AG005681; United States / NIA NIH HHS / AG / P30 AG012300; United States / NIA NIH HHS / AG / P50-AG05681
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Ubiquitin; 0 / tau Proteins
  • [Other-IDs] NLM/ NIHMS81226; NLM/ PMC2635119
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69. Guan L, Li ZY, Zhao JY, Xu XX, Wen T, Zhang YL: [Dynamic changes of hemorheology in rats after carbon monoxide poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2010 Dec;28(12):885-90
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  • OBJECTIVE: To investigate the startup detail of circulation dysfunction and its role in the progress of delayed neuropsychologic sequelae (DNS) after carbon monoxide (CO) poisoning with comparison with the model of ischemia-reperfusion.
  • METHODS: The ischemia-reperfusion rat model was established by Pulsinelli-Brierley method, and the CO poisoning rats model by i.p. injected with CO repeatedly respectively, and the rats were identified with DNS following the experiment of pathology and the ethnology.
  • CONCLUSION: There are significantly sustained hyper-coagulation and hyper-viscosity with circulation in rats after CO poisoning compared with ischemia-reperfusion model during the period of DNS, which might contribute to increase cerebral circulation resistance, blocked blood flow, and deteriorate hypoxemia in progression of DNS.
  • [MeSH-minor] Animals. Disease Models, Animal. Hemorheology. Male. Rats. Rats, Sprague-Dawley. Reperfusion Injury / physiopathology

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  • (PMID = 21241595.001).
  • [ISSN] 1001-9391
  • [Journal-full-title] Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
  • [ISO-abbreviation] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
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70. Kogita S, Imai Y, Okada M, Kim T, Onishi H, Takamura M, Fukuda K, Igura T, Sawai Y, Morimoto O, Hori M, Nagano H, Wakasa K, Hayashi N, Murakami T: Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow. Eur Radiol; 2010 Oct;20(10):2405-13
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  • OBJECTIVE: To retrospectively investigate enhancement patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI in relation to histological grading and portal blood flow.
  • METHODS: Sixty-nine consecutive patients with 83 histologically proven HCCs and DNs were studied.
  • RESULTS: Post-contrast EOB ratios significantly decreased as the degree of differentiation declined in DNs (1.00 ± 0.14) and well, moderately and poorly differentiated HCCs (0.79 ± 0.19, 0.60 ± 0.27, 0.49 ± 0.10 respectively).
  • Gd-EOB-DTPA uptake, assessed by EOB enhancement ratios, deceased slightly in DNs and still more in HCCs, while there was no statistical difference in the decrease between different histological grades of HCC.
  • Reductions in portal blood flow were observed less frequently than decreases in Gd-EOB-DTPA uptake in DNs and well-differentiated HCCs.
  • The hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may help estimate histological grading, although difficulties exist in differentiating HCCs from DNs.

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  • (PMID = 20490505.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
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71. Moon KO, Choi KH, Kang HY, Oh JI, Jang SB, Park CS, Lee JH, Cha J: Probing the critical residues for intramolecular fructosyl transfer reaction of a levan fructotransferase. J Microbiol Biotechnol; 2008 Jun;18(6):1064-9
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  • AL-210 LFTase, an error-prone PCR mutagenesis process was carried out, and the mutants that led to a shift in activity from transfructosylation towards hydrolysis of levan were screened by the DNS method.

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  • (PMID = 18600048.001).
  • [ISSN] 1017-7825
  • [Journal-full-title] Journal of microbiology and biotechnology
  • [ISO-abbreviation] J. Microbiol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Disaccharides; 0 / Fructans; 17669-60-2 / levanbiose; 546-42-9 / difructose anhydride IV; 9013-95-0 / levan; EC 2.4.1.- / Hexosyltransferases; EC 2.4.1.- / levan fructotransferase
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72. Shkute N, Stivrina N: 5-Azacytidine decreases fragmentation of nuclear DNA and pigment formation in first leaf cells of barley seedlings. Cell Biol Int; 2005 Dec;29(12):1025-31
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  • The influence of 5azaC (100 microg/ml) on nuclear DNS amount and its fragmentation in the first leaf cells of barley was studied.

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  • (PMID = 16309931.001).
  • [ISSN] 1065-6995
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Plant; M801H13NRU / Azacitidine
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73. Yang JS, Liau KL, Hwang CY, Wang CM: Photoinduced single- versus double-bond torsion in donor-acceptor-substituted trans-stilbenes. J Phys Chem A; 2006 Jul 6;110(26):8003-10
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  • In contrast, our results support the previously proposed TICT state for trans-4-(N,N-dimethylamino)-4'-nitrostilbene (DNS).

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  • (PMID = 16805484.001).
  • [ISSN] 1089-5639
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Bandani AR, Balvasi A: Comparison of alpha-amylase activity in larval stages of flour beetles, Tribolium confusum (Coleoptera: Tenebionidae). Commun Agric Appl Biol Sci; 2006;71(2 Pt B):537-41
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  • The supernatants were used as enzyme source in assays. alpha-Amylase activity was assayed by the dinitrosalicylic acid (DNS) procedure using 1% soluble starch (Merck) as substrate.

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  • (PMID = 17385521.001).
  • [ISSN] 1379-1176
  • [Journal-full-title] Communications in agricultural and applied biological sciences
  • [ISO-abbreviation] Commun. Agric. Appl. Biol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 3.2.1.1 / alpha-Amylases
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75. Xu M, Wu S, Zeng F, Yu C: Cyclodextrin supramolecular complex as a water-soluble ratiometric sensor for ferric ion sensing. Langmuir; 2010 Mar 16;26(6):4529-34
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  • This water-soluble FRET system consists of a dansyl-linked beta-cyclodextrin (beta-CD-DNS) and a spirolactam rhodamine-linked adamantane (AD-SRhB).

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  • (PMID = 19852476.001).
  • [ISSN] 1520-5827
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Ferric Compounds; 059QF0KO0R / Water
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76. Giuffrida A, Contino A, Maccarrone G, Messina M, Cucinotta V: The 3-amino-derivative of gamma-cyclodextrin as chiral selector of Dns-amino acids in electrokinetic chromatography. J Chromatogr A; 2009 Apr 24;1216(17):3678-86
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  • [Title] The 3-amino-derivative of gamma-cyclodextrin as chiral selector of Dns-amino acids in electrokinetic chromatography.
  • The enantioseparation of the enantiomeric pairs of 10 Dns derivatives of alpha-amino acids was successfully carried out by using for the first time the 3-amino derivative of the gamma-cyclodextrin.

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  • (PMID = 19124131.001).
  • [ISSN] 1873-3778
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Dansyl Compounds; 0 / gamma-Cyclodextrins; KZJ0BYZ5VA / gamma-cyclodextrin
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77. Tano C, Son SH, Furukawa J, Furuike T, Sakairi N: Dodecyl thioglycopyranoside sulfates: novel sugar-based surfactants for enantiomeric separations by micellar electrokinetic capillary chromatography. Electrophoresis; 2008 Jul;29(13):2869-75
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  • Under the optimized conditions (50 mM phosphate buffer at pH 6.5, 30 mM surfactant, 20 kV), the enantiomeric separations of five dansylated amino acids (Dns-AAs) were achieved within approximately 20 min with the migration order of Val<Met<Leu<Phe<Trp.
  • With 6-betaGlcD, all D-forms of Dns-AAs were found to migrate faster than the corresponding L-forms, whereas the migration order of the enantiomers was completely reversed with the surfactant 6-betaGlcL having inversed absolute configuration of 6-betaGlcD.

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  • (PMID = 18546163.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Dansyl Compounds; 0 / Sulfuric Acid Esters; 0 / Surface-Active Agents; 0 / Thioglycosides
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78. Ooigawa H, Nawashiro H, Fukui S, Otani N, Osumi A, Toyooka T, Shima K: The fate of Nissl-stained dark neurons following traumatic brain injury in rats: difference between neocortex and hippocampus regarding survival rate. Acta Neuropathol; 2006 Oct;112(4):471-81
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  • We studied the fate of Nissl-stained dark neurons (N-DNs) following traumatic brain injury (TBI).
  • N-DNs were investigated in the cerebral neocortex and the hippocampus using a rat lateral fluid percussion injury model.
  • In the neocortex, the number of dead neurons at 24 h postinjury was significantly less than that of the observed N-DNs in the earlier phase.
  • Only a few N-DNs increased their pERK immunoreactivity.
  • On the other hand, in the hippocampus the number of dead neurons was approximately the same number as that of the N-DNs, and most N-DNs showed an increased pERK immunoreactivity.
  • These data suggest that not all N-DNs inevitably die especially in the neocortex after TBI.
  • The fate of N-DNs is thus considered to differ depending on brain subfields.
  • [MeSH-minor] Analysis of Variance. Animals. Cell Count / methods. Disease Models, Animal. Extracellular Signal-Regulated MAP Kinases / metabolism. Immunohistochemistry. Male. Rats. Rats, Sprague-Dawley. Staining and Labeling. Statistics, Nonparametric. Survival Rate. Time Factors

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  • (PMID = 16858608.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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79. Hunzelmann N, Moinzadeh P, Genth E, Krieg T, Lehmacher W, Melchers I, Meurer M, Müller-Ladner U, Olski TM, Pfeiffer C, Riemekasten G, Schulze-Lohoff E, Sunderkoetter C, Weber M, German Network for Systemic Scleroderma Centers: High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy. Arthritis Res Ther; 2009;11(2):R30
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  • Among patients with overlap disease characteristics, 63.5% received corticosteroids (P < 0.0001 vs. limited cutaneous SSc).

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  • (PMID = 19261182.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Immunosuppressive Agents
  • [Other-IDs] NLM/ PMC2688174
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80. Sklebar D, Semanjski K, Kos M, Sklebar I, Jezek D: Foetal Leydig cells and the neuroendocrine system. Coll Antropol; 2008 Jan;32 Suppl 1:149-53
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  • Therefore, the aim of our study was to investigate the development of human foetal Leydig cells in different weeks of gestation (wg) and to check if these cells express certain markers characteristic of the diffuse neuroendocrine system (DNS).

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  • (PMID = 18405075.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Croatia
  • [Chemical-registry-number] EC 4.2.1.11 / Phosphopyruvate Hydratase
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81. Prabhakaran VC, Font RL: Cutaneous malignant melanoma metastatic to the vitreous. Retina; 2007 Mar;27(3):379-81
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  • [Title] Cutaneous malignant melanoma metastatic to the vitreous.
  • We describe a patient with dysplastic nevus syndrome and cutaneous melanoma in whom vitreous involvement was the first sign of metastatic disease.
  • [MeSH-major] Eye Neoplasms / secondary. Melanoma / secondary. Skin Neoplasms / pathology. Vitreous Body / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Dysplastic Nevus Syndrome / pathology. Eye Enucleation. Fatal Outcome. Humans. Male. Middle Aged

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  • (PMID = 17460596.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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82. Park HS, Lee JM, Kim SH, Chang S, Kim SJ, Han JK, Choi BI: Differentiation of well-differentiated hepatocellular carcinomas from other hepatocellular nodules in cirrhotic liver: value of SPIO-enhanced MR imaging at 3.0 Tesla. J Magn Reson Imaging; 2009 Feb;29(2):328-35
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  • MATERIALS AND METHODS: This study included 114 patients with 216 histologically confirmed hepatocellular nodules, i.e., 23 dysplastic nodules (DNs), 37 WD-HCCs, and 156 moderately or poorly differentiated HCCs (MD-/PD HCCs), who underwent SPIO-enhanced MRI at 3.0T.
  • Alternatively, 22 of 23 DNs (95.7%) showed low- or iso SI, and 145 of 156 (94.9%) MD-/PD HCCs showed strong high SI.
  • When iso SI with high SI foci or subtle homogenous high SI nodule was considered as diagnostic criteria for WD-HCC, we could identify 56.8% of the WD-HCCs but only 4.4% of the DNs and 3.2% of the MD-/PD HCCs.
  • CONCLUSION: WD-HCCs have characteristic enhancement features that differentiate them from DNs and MD-/PD HCCs on SPIO-enhanced 3.0T MRI.

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  • (PMID = 19161184.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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83. Berón de Astrada M, Tuthill JC, Tomsic D: Physiology and morphology of sustaining and dimming neurons of the crab Chasmagnathus granulatus (Brachyura: Grapsidae). J Comp Physiol A Neuroethol Sens Neural Behav Physiol; 2009 Aug;195(8):791-8
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  • This study provides a description of SNs and DNs in a second crustacean species, the crab Chasmagnathus.
  • SNs and DNs of the crab arborize extensively in the medulla and the axons project to the midbrain.
  • Upon a light pulse, SNs depolarize and increase the firing rate while DNs hyperpolarize and reduce firing.
  • In contrast, DNs show maximal depolarization to near horizontal e-vector orientations.
  • Yet, we found that the location, morphology and physiology of SNs and DNs of the crab are nearly identical to those described in the crayfish.

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  • (PMID = 19424704.001).
  • [ISSN] 1432-1351
  • [Journal-full-title] Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
  • [ISO-abbreviation] J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / neurobiotin; 6SO6U10H04 / Biotin
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84. Dobie J: Palliative care provision for older people in care homes. Br J Community Nurs; 2010 Apr;15(4):170-6
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  • There is a paucity of research in relation to district nurses' (DNs) experiences of palliative care provision in adult care homes (CHs) despite their substantial involvement.
  • The aim of this study was to demonstrate the current involvement of DNs in CHs and identify the potential implications for future practice in providing palliative care in this setting.
  • The findings suggested that even experienced DNs, wanted support and education about when to commence palliative care.
  • They also wanted earlier involvement with CH residents who have a life-limiting condition and CH managers were seen as being essential contributors towards planning care.
  • There was concern among DNs as to how the Liverpool Care Pathway could be introduced into CHs with untrained carers and finally, DN alignment to CHs was shown to improve continuity of care for residents and produce more effective partnership working between DNs, general practitioners and CH staff.

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  • (PMID = 20559162.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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85. Gaasbeek EJ, Wagenaar JA, Guilhabert MR, Wösten MM, van Putten JP, van der Graaf-van Bloois L, Parker CT, van der Wal FJ: A DNase encoded by integrated element CJIE1 inhibits natural transformation of Campylobacter jejuni. J Bacteriol; 2009 Apr;191(7):2296-306
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  • Analysis of CJIE1 indicated the presence of dns (CJE0256), which is annotated as a gene encoding an extracellular DNase.
  • DNase assays using a defined dns mutant and a dns-negative strain expressing Dns from a plasmid indicated that Dns is an endogenous DNase.
  • The DNA-hydrolyzing activity directly correlated with the natural transformability of the knockout mutant and the dns-negative strain expressing Dns from a plasmid.

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  • (PMID = 19151136.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA Transposable Elements; EC 3.1.- / Deoxyribonucleases
  • [Other-IDs] NLM/ PMC2655492
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86. Sugiura C, Miyata H, Ueda M, Ohama E, Vinters HV, Ohno K: Immunohistochemical expression of fibroblast growth factor (FGF)-2 in epilepsy-associated malformations of cortical development (MCDs). Neuropathology; 2008 Aug;28(4):372-81
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  • To elucidate the biological significance of dysplastic cells in malformations of cortical development, an immunohistochemical study was performed to investigate fibroblast growth factor-2 (FGF-2) expression in corticectomy specimens from epilepsy patients, including focal cortical dysplasia (FCD) with balloon cells (BCs) (n=4; age/sex=2M, 14F, 24M, 45M), tubers of tuberous sclerosis complex (TSC-tubers) (n=2; 1F, 3F), FCD without BCs (n=3; 23F, 23M, 25M), and gliotic lesions (n=3; 12M, 25M, 29M).
  • In all dysplastic lesions, FGF-2 was detected in the astrocytic nuclei, and cytoplasm and/or nuclei of BCs.
  • Dysplastic neurons (DNs) in FCD with BCs and TSC-tubers were variably positive for FGF-2 in the cytoplasm, but FGF-2 was not detected in the neurons of FCD without BCs.
  • These results, together with previous reports showing FGF-2 expression in neuroblasts and glioblasts in human fetal brain, and mainly in astrocytes in adult brain, suggest that FGF-2 expression in MCDs reflects incomplete differentiation and maturation of dysplastic cells, and that FGF-2-IR% is associated with histological subtypes of MCD, reflecting the timing of insults underlying the pathogenesis of each disorder.

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  • (PMID = 18179408.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Nerve Tissue Proteins; 0 / OLIG2 protein, human; 103107-01-3 / Fibroblast Growth Factor 2
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87. Santanello NC, DeMuro-Mercon C, Shah SR, Schenkel EJ, Ratner PH, Dass SB, Norquist JM, Philip G: Validation of the nighttime symptoms score as a clinically relevant measure of allergic rhinitis. Allergy Asthma Proc; 2006 May-Jun;27(3):231-9
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  • [Title] Validation of the nighttime symptoms score as a clinically relevant measure of allergic rhinitis.
  • The aim of this study was to validate the nighttime symptoms score (NSS), which incorporates individual scores for difficulty going to sleep and nighttime awakening caused by nasal symptoms and nasal congestion on awakening, as a clinically relevant measure of allergic rhinitis (AR).
  • Fifty-five general season AR (SAR) symptom items were generated by interviews with 14 patients with symptomatic SAR without concomitant asthma for use in an Importance Rating Questionnaire (IRQ).
  • A second group of patients (n = 83) with symptomatic AR without asthma rated the importance of each item on the IRQ.
  • Correlation coefficients were calculated to examine the relationships between the six sleep quality questions on the IRQ and the other AR symptoms and between the symptom questions of the NSS, the Daytime Nasal Symptoms Score (DNSS), and the individual domains of the Rhinoconjunctivitis Quality-of-Life Questionnaire (RQLQ).
  • The majority (94%) of patients with active AR reported some degree of symptoms relating to sleep quality.
  • The six sleep quality items on the IRQ were selected by 71-84% of patients.
  • The sleep quality items were more highly correlated with each other (r = 0.48-0.85) than with the four items of the DNSS (r = 0.01-0.42).
  • There was a moderate-to-strong correlation of the RQLQ sleep domain with the two sleep questions of the NSS (r = 0.44-0.57).
  • The individual symptom questions of the NSS and the DNSS were only moderately correlated with each other.
  • Sleep quality questions measure aspects of SAR that are not captured by daytime SAR symptoms.
  • The results show that the NSS is a valid and relevant clinical measure of the impact of nighttime sleep disturbance on AR patients.


88. Cheng AC, Wong AC, Sze AM, Yuen HK: Limited nasal septoplasty by ophthalmologists during endonasal dacryocystorhinostomy: is it safe? Ophthal Plast Reconstr Surg; 2009 Jul-Aug;25(4):293-5
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  • PURPOSE: Significant deviated nasal septum (DNS) may preclude the performance of endonasal dacryocystorhinostomy (DCR).
  • The purpose of this study was to investigate the outcomes of limited nasal septoplasty in tackling signficant DNS performed by trained ophthalmologists during endonasal DCR.
  • METHODS: In this retrospective interventional case series, the records of all patients requiring limited nasal septoplasty for significant DNS during endonasal DCR at 2 tertiary ophthalmic centers in Hong Kong during January 2006 to December 2007 were reviewed.
  • CONCLUSIONS: In the hands of trained ophthalmic lacrimal surgeons, limited nasal septoplasty is an effective and safe procedure during endonasal DCR, allowing better exposure of the surgical field in patients with significant DNS.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Female. Follow-Up Studies. Humans. Intraoperative Period. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 19617788.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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89. Pletneva EV, Gray HB, Winkler JR: Many faces of the unfolded state: conformational heterogeneity in denatured yeast cytochrome C. J Mol Biol; 2005 Jan 28;345(4):855-67
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  • We have measured fluorescence energy-transfer (FET) kinetics from a dansyl fluorophore (Dns) introduced by derivatization of a Cys side-chain to the Fe(III) heme covalently attached to unfolded yeast iso-1 cytochrome c (cyt).
  • We detect relatively large populations of compact structures in unfolded Dns(C50)cyt, Dns(C39)cyt, and Dns(C66)cyt.

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  • (PMID = 15588831.001).
  • [ISSN] 0022-2836
  • [Journal-full-title] Journal of molecular biology
  • [ISO-abbreviation] J. Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM068461
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Saccharomyces cerevisiae Proteins; 9007-43-6 / Cytochromes c
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90. Nagy B, Bán Z, Papp Z: [Effect of the DNA isolation method on the results of multiple fluorescent PCR and DNA fragment analysis]. Orv Hetil; 2005 Jul 17;146(29):1539-41
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  • [Transliterated title] A DNS-izolálási módszer hatá'sa a multiplex fluoreszcens PCR- es DNS-fragmens-analízis eredményeire.

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  • (PMID = 16136775.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 9007-49-2 / DNA
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91. Zhao X, He GW: Space-time correlations of fluctuating velocities in turbulent shear flows. Phys Rev E Stat Nonlin Soft Matter Phys; 2009 Apr;79(4 Pt 2):046316
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  • The similarity assumptions are justified using the Kolmogorov similarity hypotheses and verified using the direct numerical simulation (DNS) of turbulent channel flows.
  • The DNS of turbulent channel flows supports the prediction: the correlation functions exhibit a fair good collapse, when plotted against the normalized space and time separations defined by the elliptic model.

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  • (PMID = 19518342.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Qi XQ, Wen J, Qi ZH: New 3D graphical representation of DNA sequence based on dual nucleotides. J Theor Biol; 2007 Dec 21;249(4):681-90
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  • We introduce a 3D graphical representation of DNA sequences based on the pairs of dual nucleotides (DNs).

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  • (PMID = 17931659.001).
  • [ISSN] 0022-5193
  • [Journal-full-title] Journal of theoretical biology
  • [ISO-abbreviation] J. Theor. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9004-22-2 / Globins; 9007-49-2 / DNA
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93. Suzuki M, Iijima M, Nishimura A, Tomozoe Y, Kamei D, Yamada M: Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence. FEBS J; 2005 Aug;272(15):3975-87
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  • The C-terminal 19-residue sequence (SGYGKVSRRGGHQNSYKPY) was identified as an hnRNP D nucleocytoplasmic shuttling sequence (DNS).
  • In vitro nuclear transport using permeabilized cells indicated that nuclear import of DNS is mediated by transportin-1 (Trn-1).
  • DNS accumulation in the nucleus was dependent on Trn-1, Ran, and energy in multiple rounds of nuclear transport.
  • Use of DNS with deletions, alanine scanning mutagenesis and point mutations revealed that two separate regions (the N-terminal seven residues and the C-terminal two residues) are crucial for in vivo and in vitro transport as well as for interaction with Trn-1.

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  • (PMID = 16045768.001).
  • [ISSN] 1742-464X
  • [Journal-full-title] The FEBS journal
  • [ISO-abbreviation] FEBS J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Heterogeneous-Nuclear Ribonucleoprotein D; 0 / Protein Isoforms; 0 / Protein Sorting Signals
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94. Huang XG, Xu JQ, Ren L, Qiu C, Zhang N, Liu LX, Wan YM, Peng H, Shao YM: [Intranasal priming with HIV DNA vaccine and systemic boosting with recombinant vaccinia induce vigorous immune responses: experiment with mice]. Zhonghua Yi Xue Za Zhi; 2006 Nov 28;86(44):3109-13
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  • The number of SFCs of the 1-dose DNA-vaccine subgroup was [(30 +/- 18) SFCs/10(6) spleen cells], significantly higher than that of the only DNS vaccine group (P < 0.01).

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  • (PMID = 17313761.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AIDS Vaccines; 0 / HIV Antibodies; 0 / Immunoglobulin A; 0 / Vaccines, DNA
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95. Vincent TE, Gendeh BS: The association of concha bullosa and deviated nasal septum with chronic rhinosinusitis in functional endoscopic sinus surgery patients. Med J Malaysia; 2010 Jun;65(2):108-11
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  • Chronic rhinosinusitis (CRS) remains a prevalent disease and a major cause of morbidity for many patients and functional endoscopic sinus surgery (FESS) is the gold standard for the treatment of CRS.
  • The data revealed that deviated nasal septum (DNS) and concha bullosa (CB) were the two commonest anatomical variations in the nasal cavity.
  • DNS is also prevalent but has no significant statistical relationship with sex, age, ethnic group in the local context.
  • CB and DNS are coincidental variations and this study disprove that DNS is associated with CB in its development and pathogenesis of CRS.

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  • (PMID = 23756792.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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96. Pomposelli R, Piasere V, Andreoni C, Costini G, Tonini E, Spalluzzi A, Rossi D, Quarenghi C, Zanolin ME, Bellavite P: Observational study of homeopathic and conventional therapies in patients with diabetic polyneuropathy. Homeopathy; 2009 Jan;98(1):17-25
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  • Primary outcome was diabetic neuropathy symptom (DNS) score, secondary outcomes were clinical evolution and short-form-36 (SF-36)-evaluated quality of life (QOL).
  • DNS improved in both groups during the observation period, but the change with respect to baseline was statistically significant only in Homeopathic group at T1 (P=0.016).

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  • (PMID = 19135955.001).
  • [ISSN] 1476-4245
  • [Journal-full-title] Homeopathy : the journal of the Faculty of Homeopathy
  • [ISO-abbreviation] Homeopathy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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97. Kaufman Y, Heled M, Perk J, Razin A, Shemer R: Protein-binding elements establish in the oocyte the primary imprint of the Prader-Willi/Angelman syndromes domain. Proc Natl Acad Sci U S A; 2009 Jun 23;106(25):10242-7
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  • The elements: DMR, DNS, 2 OCTA sequences, SOX, E1, and E2 bind specific proteins that form at least 2 protein complexes.
  • (iii) DNS and DMR bind a multiprotein complex that may facilitate interaction between AS-IC and PWS-IC, mediating the inactivation in cis of PWS-IC; and (iv) all 7 elements participate in maintaining an unmethylated PWS-IC in the oocyte, which is essential for its maternal methylation later in development.
  • [MeSH-major] Angelman Syndrome / genetics. Genomic Imprinting. Multiprotein Complexes / metabolism. Oocytes / metabolism. Prader-Willi Syndrome / genetics

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  • (PMID = 19506242.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Multiprotein Complexes
  • [Other-IDs] NLM/ PMC2700935
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98. Hogan RC, Cuzzi JN: Cascade model for particle concentration and enstrophy in fully developed turbulence with mass-loading feedback. Phys Rev E Stat Nonlin Soft Matter Phys; 2007 May;75(5 Pt 2):056305
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  • A cascade model is described based on multiplier distributions determined from three-dimensional (3D) direct numerical simulations (DNS) of turbulent particle laden flows, which include two-way coupling between the phases at global mass loadings equal to unity.
  • DNS results for particle concentration and enstrophy at Taylor microscale Reynolds numbers in the range 34-170 were used to directly determine multiplier distributions on spatial scales three times the Kolmogorov length scale.

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  • (PMID = 17677162.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Eyanagi R, Toda A, Ishii Y, Saito H, Soeda S, Shimeno H, Shigematsu H: Antigenicity of sulfanilamide and its metabolites using fluorescent-labelled compounds. Xenobiotica; 2005 Sep;35(9):911-25
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  • In other words, 5-dimethylamino-N-(4-aminobenzyl)-naphthalenesulfonamide (DNS-4ABA), 5-dimethylamino-N-(4-hydroxylaminobenzyl)-1-naphthalenesulfonamide (DNS-4HABA) and 5-dimethylamino-N-(4-nitrosobenzyl)-1-naphthalenesulfonamide (DNS-4NSBA) were synthesized as model haptens.
  • When analysed by HPLC, a conjugate of DNS-4HABA and glutathione (GSH) with nucleophilic amino acids had two peaks (P-1 and P-2).
  • FAB-MS and 1H-NMR revealed that the DNS-4HABA-GSH conjugate consisted of sulphinamide and semimercaptal.
  • The reactivity of GSH to DNS-4ABA, DNS-4HABA and DNS-4NSBA was quantified by HPLC using an oxidization system (horseradish peroxidase/H2O2).
  • The results show that production of DNS-4NSBA-GSH-conjugate was four to eight times higher than that of DNS-4HABA-GSH conjugate, but that DNS-4ABA did not bind with GSH.
  • Skin reactions were assessed using guinea pigs, and strong delayed erythema was seen with DNS-4NSBA, which bound most strongly with GSH, whereas weak delayed erythema was seen with DNS-4ABA, which did not bind with GSH.
  • DNS-4HABA enzymatically bound with proteins in rat and guinea pig liver cytosol and microsomal fractions.
  • The proteins that bound to DNS-4HABA were purified by HPLC and then subjected to N-terminal amino acid analysis.
  • When DNS-4HABA or DNS-4NSBA binds to proteins that play important roles in the body, unexpected adverse reactions may occur.

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  • (PMID = 16308284.001).
  • [ISSN] 0049-8254
  • [Journal-full-title] Xenobiotica; the fate of foreign compounds in biological systems
  • [ISO-abbreviation] Xenobiotica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Sulfanilamides; 21240MF57M / sulfanilamide
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100. Rota E, Quadri R, Fanti E, Poglio F, Paolasso I, Ciaramitaro P, Cossa FM, Cocito D: Clinical and electrophysiological correlations in type 2 diabetes mellitus at diagnosis. Diabetes Res Clin Pract; 2007 Apr;76(1):152-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • (2) the clinical value of both the Diabetic Neuropathy Index (DNI) and the Diabetic Neuropathy Score (DNS), and their reciprocal concordance, as a screening method for neuropathy.
  • Peripheral neuropathy was observed in 72% of the subjects (its staging was similar to that of patients with longer disease history), while another 10% of them showed a borderline neuropathy.
  • No correlation was found between metabolic indexes and DNI/DNS parameters.






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