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1. Jia F, Figueroa SD, Gallazzi F, Balaji BS, Hannink M, Lever SZ, Hoffman TJ, Lewis MR: Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates. J Nucl Med; 2008 Mar;49(3):430-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates.
  • The bcl-2 gene is overexpressed in non-Hodgkin's lymphoma (NHL), such as small lymphocytic lymphoma (SLL), and many other cancers.
  • In vitro studies were performed in Mec-1 SLL cells, which express both bcl-2 messenger RNA and somatostatin receptors.
  • Biodistributions and microSPECT/CT studies were performed in Mec-1-bearing SCID (severe combined immunodeficiency) mice, a new animal model of human SLL.
  • CONCLUSION: A new (111)In-labeled antisense PNA-peptide conjugate demonstrated proof of principle for molecular imaging of bcl-2 expression in a new mouse model of human SLL.
  • [MeSH-major] Indium Radioisotopes / pharmacokinetics. Leukemia, Lymphocytic, Chronic, B-Cell / metabolism. Leukemia, Lymphocytic, Chronic, B-Cell / radionuclide imaging. Peptide Nucleic Acids / pharmacokinetics. Proto-Oncogene Proteins c-bcl-2 / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Isotope Labeling. Metabolic Clearance Rate. Mice. Mice, SCID. Molecular Probe Techniques. Organ Specificity. Radiopharmaceuticals / chemical synthesis. Radiopharmaceuticals / pharmacokinetics. Tissue Distribution

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  • (PMID = 18287262.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 103130
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indium Radioisotopes; 0 / Peptide Nucleic Acids; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Radiopharmaceuticals
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2. Saxena A, Memauri B, Hasegawa W: Initial diagnosis of small lymphocytic lymphoma in parotidectomy for Warthin tumour, a rare collision tumour. J Clin Pathol; 2005 Mar;58(3):331-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Initial diagnosis of small lymphocytic lymphoma in parotidectomy for Warthin tumour, a rare collision tumour.
  • Warthin tumours (WT) and malignant lymphomas are only rarely associated, and most are examples of involvement of the lymphoid stroma of WT by a disseminated lymphoma.
  • This report describes a case where excision of a parotid mass led to the initial diagnosis of WT and small lymphocytic lymphoma (SLL).
  • The diagnosis of SLL was confirmed by immunohistochemistry and molecular studies.
  • This case highlights the extremely rare association of SLL with WT and the importance of evaluation of the WT stroma, where the pale proliferation centres of SLL may mimic germinal centres of reactive lymphoid nodules.
  • [MeSH-major] Adenolymphoma / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 15735173.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770608
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3. Khaled S, Gotlieb V, Schuster IP, Saif MW: Multiple lymphomatous polyposis associated with small lymphocytic lymphoma: a unique presentation. J Gastrointestin Liver Dis; 2008 Dec;17(4):461-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple lymphomatous polyposis associated with small lymphocytic lymphoma: a unique presentation.
  • Multiple lymphomatous polyposis (MLP) is a rare extra-nodal manifestation of lymphoma.
  • In most cases, MLP is associated with mantle cell lymphoma (MCL).
  • We report a 66-year-old male diagnosed with small lymphocytic lymphoma (SLL)/chronic lymphocytic lymphoma (CLL), who showed evidence of rectal bleeding.
  • A CT-scan of the abdomen and pelvis showed an enlarged spleen, multiple paraaortic and mesenteric lymph nodes, and some diverticular pouching along the antimesenteric border of the pelvic colon.
  • A colonoscopy revealed the presence of multiple polypoid lesions, biopsies of which showed diffuse lymphoid infiltrate without any identifiable follicles.
  • Immunohistochemical analysis combined with a Fluorescence In-Situ Hybridization (FISH) study excluded the diagnosis of MCL.
  • A bone marrow aspiration biopsy demonstrated diffuse infiltration of the bone marrow with low grade lymphocytes that expressed CD 20, CD5 and CD23, with negative BCL-1, t (11;.
  • A diagnosis of B-cell CLL with kappa light chain restriction was made.
  • Multiple lymphomatous polyposis is considered to be a digestive counterpart to MCL and can therefore be considered as a presentation of MCL.
  • The patient's bone marrow revealed a B-cell lymphoma of CLL/SLL phenotype, which to our knowledge has not been linked to MLP in previously reported cases.
  • [MeSH-major] Colonic Polyps / diagnosis. Colorectal Neoplasms / diagnosis. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Lymphoma, Mantle-Cell / diagnosis
  • [MeSH-minor] Aged. B-Lymphocytes / metabolism. Biomarkers, Tumor / metabolism. Bone Marrow / pathology. Diagnosis, Differential. Humans. Male

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  • (PMID = 19104711.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Türköz HK, Polat N, Akin I, Ozcan D: Micronodular T-cell/histiocyte-rich B-cell lymphoma of the spleen in a case of small lymphocytic lymphoma: a Richter's transformation. Ups J Med Sci; 2010 Aug;115(3):217-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Micronodular T-cell/histiocyte-rich B-cell lymphoma of the spleen in a case of small lymphocytic lymphoma: a Richter's transformation.
  • Abstract A case of micronodular T-cell/histiocyte-rich B-cell lymphoma of the spleen who had a prior diagnosis of small lymphocytic lymphoma is presented.
  • Micronodular T-cell/histiocyte-rich B-cell lymphoma of the spleen was first described in 2003, and very few cases have been reported since then.
  • This is the first reported case supervening in a patient with pre-existing chronic lymphocytic lymphoma.
  • We review its clinical, pathologic, and immunohistochemical features and the difficulties we encountered during diagnosis.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 20218944.001).
  • [ISSN] 2000-1967
  • [Journal-full-title] Upsala journal of medical sciences
  • [ISO-abbreviation] Ups. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2939524
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5. Catrina Reading F, Schlette EJ, Stewart JM, Keating MJ, Katz RL, Caraway NP: Fine-needle aspiration biopsy findings in patients with small lymphocytic lymphoma transformed to hodgkin lymphoma. Am J Clin Pathol; 2007 Oct;128(4):571-8
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  • [Title] Fine-needle aspiration biopsy findings in patients with small lymphocytic lymphoma transformed to hodgkin lymphoma.
  • Although small lymphocytic lymphoma (SLL) is an indolent lymphoma, approximately 5% of cases can transform to a higher-grade lymphoma, rarely Hodgkin lymphoma (HL).
  • We report the fine-needle aspiration (FNA) results of 6 cases of SLL/chronic lymphocytic leukemia (CLL) that transformed to HL.
  • The patients included 5 men and 1 woman, ranging in age from 49 to 72 years at the time of SLL/CLL diagnosis with time for development of HL ranging from 0 to 95 months (mean, 49.3 months).
  • The FNA diagnoses were SLL with HL transformation (2 cases), SLL with large atypical cells (1 case), and atypical lymphoid proliferation with large atypical cells (3 cases).
  • Flow cytometry performed in 5 cases (2 FNA specimens) demonstrated a monoclonal B-cell population with CD19/CD5 coexpression.
  • The presence of large atypical mononucleated and binucleated cells in lymph node FNA specimens from patients with SLL/CLL with progressive adenopathy should raise the possibility of transformation to HL.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Hodgkin Disease / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Epstein-Barr Virus Infections / diagnosis. Epstein-Barr Virus Infections / virology. Female. Flow Cytometry. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / isolation & purification. Humans. Lymph Nodes / pathology. Male. Middle Aged. RNA, Viral / analysis

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  • (PMID = 17875507.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
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6. Campidelli C, Sabattini E, Piccioli M, Rossi M, De Blasi D, Miraglia E, Rodriguez-Abreu D, Franscini LL, Bertoni F, Mazzucchelli L, Cavalli F, Zucca E, Pileri SA: Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases. Hum Pathol; 2007 May;38(5):787-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases.
  • We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma.
  • Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor gamma and immunoglobulin heavy chain gene rearrangements.
  • One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia.
  • To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / complications. Lymphoma, B-Cell / complications. Lymphoma, T-Cell, Peripheral / complications

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  • (PMID = 17270243.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Dores GM, Anderson WF, Curtis RE, Landgren O, Ostroumova E, Bluhm EC, Rabkin CS, Devesa SS, Linet MS: Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology. Br J Haematol; 2007 Dec;139(5):809-19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology.
  • The 2001 World Health Organization classification scheme considers B-cell chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) in an aggregate category (CLL/SLL) because of shared clinicopathological features.
  • We have estimated age-adjusted incidence rates (IRs) of CLL and SLL in the population-based Surveillance, Epidemiology and End Results Program in the United States to analyse patterns of CLL and SLL separately and jointly.
  • Age-standardized to the 2000 US population, overall IRs were 3.83 per 100 000 person-years for CLL (n = 15 676) and 1.31 for SLL (n = 5382) during 1993-2004.
  • Incidence of the combined entity, CLL/SLL, was 90% higher among males compared to females, and the male:female IR ratio was significantly higher for CLL (1.98) than for SLL (1.67).
  • CLL/SLL IRs were 25% and 77% lower among Blacks and Asian/Pacific Islanders, respectively, compared to Whites.
  • A significant reporting delay was evident for CLL but not for SLL, so that CLL/SLL temporal trends must be interpreted cautiously.
  • CLL and SLL IRs increased exponentially with age among all gender/race groups, with CLL IRs increasing more steeply with advancing age than SLL.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / epidemiology

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  • (PMID = 17941952.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Intramural
  • [Publication-country] England
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8. Caraway NP, Thomas E, Khanna A, Payne L, Zhang HZ, Lin E, Keating MJ, Katz RL: Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival. Cancer; 2008 Oct 25;114(5):315-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival.
  • BACKGROUND: Fine-needle aspiration (FNA) of lymph nodes is commonly used to assess disease progression in patients with small lymphocytic lymphoma (SLL).
  • Although cytologic features are helpful for diagnosing typical SLL and transformed large-cell lymphoma (tLCL), SLL in accelerated phase (SLLacc) is more difficult to diagnose.
  • Additional tests are needed to identify those patients who are transforming to a higher-grade lymphoma.
  • This study evaluated the use of a multicolor fluorescence in situ hybridization (FISH) probe panel specifically designed for chronic lymphocytic leukemia (CLL)/SLL and assessed the association between FISH findings and cytologic diagnosis, proliferation index, and risk of death.
  • METHODS: FNA specimens from 50 patients (32 men and 18 women; mean age, 57 years [range, 36-77 years]) with histologically confirmed CLL and/or SLL were evaluated in this study for chromosomal abnormalities of 11q22 (ATM), 12, 13q14.3, 13q34.3 (LAMP1), and 17p13.1 (p53) by using a multiprobe FISH kit.
  • The FISH findings were compared with the cytologic diagnoses (26 SLLs, 12 SLLaccs, and 11 tLCLs), Ki-67 immunostaining, and risk of death.
  • CONCLUSIONS: FISH can be performed on FNA specimens from patients with a history of SLL/CLL.
  • Knowledge of genetic abnormalities from FNAs may be useful in deciding when and how to treat indolent or progressive SLL.
  • [MeSH-major] Biopsy, Fine-Needle. Chromosome Aberrations. In Situ Hybridization, Fluorescence. Leukemia, Lymphocytic, Chronic, B-Cell / genetics. Leukemia, Lymphocytic, Chronic, B-Cell / mortality

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18683215.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Cossu A, Deiana A, Lissia A, Dedola MF, Cocco L, Palmieri G, Tanda F: Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node. Arch Pathol Lab Med; 2006 Apr;130(4):544-7
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  • [Title] Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node.
  • A diagnosis of an interdigitating dendritic cell tumor of the lymph node and a B-cell small lymphocytic lymphoma occurring in the same anatomic location was made.
  • We found that although rare cases of interdigitating dendritic cell tumor with an associated secondary malignancy have been described in the literature, to our knowledge, this is the first report of interdigitating dendritic cell tumor and synchronous neoplasm diagnosed at the same site.
  • [MeSH-major] Dendritic Cells / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Fatal Outcome. Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics. Humans. Immunoglobulin Heavy Chains / genetics. Lymph Nodes / chemistry. Lymph Nodes / pathology. Male

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  • (PMID = 16594749.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Immunoglobulin Heavy Chains
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10. Thway K, Freeman A, Woodhouse CR, Fisher C: Epithelial-stromal tumor of seminal vesicle in a patient with chromophobe renal cell carcinoma and small lymphocytic lymphoma. Ann Diagn Pathol; 2008 Dec;12(6):433-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial-stromal tumor of seminal vesicle in a patient with chromophobe renal cell carcinoma and small lymphocytic lymphoma.
  • In addition, this was associated with 2 synchronous malignant neoplasms, chromophobe renal cell carcinoma and small lymphocytic lymphoma, both of which were detected incidentally after clinical presentation because of the seminal vesicle mass.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Genital Neoplasms, Male / diagnosis. Kidney Neoplasms / diagnosis. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Neoplasms, Multiple Primary / diagnosis. Seminal Vesicles


11. Roberts AW, Wilson W, Gandhi L, O'Connor OA, Rudin CM, Brown JR, Xiong H, Chiu Y, Enschede S, Krivoshik AP: Ongoing phase I studies of ABT-263: Mitigating Bcl-X<sub>L</sub> induced thrombocytopenia with lead-in and continuous dosing. J Clin Oncol; 2009 May 20;27(15_suppl):3505

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ongoing phase 1 studies of ABT-263 show anti-tumor activity in CLL and some lymphomas (Wilson W et al, ASH. 2008).
  • We tested 2 strategies to mitigate variability in circulating platelet levels and achieve higher cumulative exposure: introducing a lower lead-in dose and using a continuous dosing (CD) (21/21 d schedule).
  • For pts receiving 150 mg lead-in, nadir occurred during this phase, and platelet levels remained relatively stable on CD for doses up to 225 mg.
  • While CD enrollment and time on study is still limited, anti-tumor activity includes 1 unconfirmed partial response (68% CT regression) in a SLL pt at 275 mg and 3 CLL pts with ≥50% lymphocyte reduction for ≥2 months.

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  • (PMID = 27961281.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Wilson W, O'Connor OO, Roberts AW, Czuczman M, Brown J, Xiong H, Xiong H, Chiu Y, Krivoshik A, Enschede S, Humerickhouse R: ABT-263 activity and safety in patients with relapsed or refractory lymphoid malignancies in particular chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). J Clin Oncol; 2009 May 20;27(15_suppl):8574

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ABT-263 activity and safety in patients with relapsed or refractory lymphoid malignancies in particular chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).
  • ABT-263 displays activity (EC<sub>50</sub> ≤ 1μM) against human lymphoid and small cell lung cancer cell lines.
  • Mechanism based preclinical toxicities include reductions in circulating lymphocytes, apoptosis of circulating platelets, and decreased spermatogenesis, mediated by inhibition of Bcl-2, Bcl-X<sub>L</sub>, and Bcl-w, respectively.
  • Among 27 CLL/SLL pts, 3 have confirmed radiographic partial responses (PR) (99%, 92% and 72%) and 2 have unconfirmed regressions, 51% and 72%.
  • 6 pts maintained a ≥50% decrease in circulating lymphocytes for ≥ 2 months and 11 pts have stable disease; of these 5 experienced minor radiographic responses (range of 36% to 49%).
  • In addition, among 40 (M06-814) lymphoma pts, 3 with follicular lymphoma achieved PR and one had a minor response (49% regression).
  • With CD dosing (16 pts), activity includes 1 unconfirmed PR in SLL & and 3 CLL pts with ≥50% lymphocyte reduction for ≥2 months duration.
  • CONCLUSIONS: ABT-263 showed favorable PK and safety profiles with anti-tumor activity in relapsed/refractory CLL/SLL and follicular lymphoma.

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  • (PMID = 27962273.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Witzig TE, Wiernik PH, Moore T, Reeder C, Cole C, Justice G, Kaplan H, Voralia M, Pietronigro D, Vose JM: Efficacy of lenalidomide oral monotherapy in relapsed or refractory indolent non-Hodgkin's lymphoma: Final results of NHL-001. J Clin Oncol; 2009 May 20;27(15_suppl):8560

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of lenalidomide oral monotherapy in relapsed or refractory indolent non-Hodgkin's lymphoma: Final results of NHL-001.
  • We conducted a phase II trial of single-agent lenalidomide in indolent non-Hodgkin's lymphoma (NHL).
  • Twenty-seven percent (6/22) of patients with follicular lymphoma grade 1 or 2, and 22% (4/18) of patients with small lymphocytic lymphoma responded to therapy.

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  • (PMID = 27960983.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Andritsos L, Furman R, Flinn IW, Foreno-Torres A, Flynn JM, Stromatt SC, Byrd JC: A phase I trial of TRU-016, an anti-CD37 small modular immunopharmaceutical (SMIP) in relapsed and refractory CLL. J Clin Oncol; 2009 May 20;27(15_suppl):3017

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase I trial of TRU-016, an anti-CD37 small modular immunopharmaceutical (SMIP) in relapsed and refractory CLL.
  • Pre-clinical studies have demonstrated CD37 SMIP mediates significantly greater direct and NK-cell mediated killing of CLL cells as compared to other therapeutic antibodies used in CLL.
  • METHODS: Patients with relapsed/refractory CLL or SLL who had adequate organ function, platelets > 30,000/mm<sup>3</sup> were eligible.
  • Dose escalation and de-escalation is based on CTC AE toxicity grades.
  • Two patients had partial clearing of leukemia cutis, and the other six had 27-94% reduction in peripheral lymphocyte count.
  • One pt. had an increase in Hgb of 40% and a reduction in lymph nodes of 36%.
  • CONCLUSIONS: To date, TRU-016 is a well tolerated treatment with minimal infusional toxicity and no observed dose limiting toxicity.
  • Encouraging reduction in tumor lymphocyte blood counts, lymph node/spleen size and improvement in normal hematopoeitic function in patients with high risk genomic CLL have already been observed at low, non-saturating doses of CD37.

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  • (PMID = 27962057.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Cole J, Pantanowitz L, Aboulafia DM: Chronic lymphocytic leukemia (CLL) coexistent with HIV: An increasing association? J Clin Oncol; 2009 May 20;27(15_suppl):7078

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronic lymphocytic leukemia (CLL) coexistent with HIV: An increasing association?
  • METHODS: Cases of HIV-associated CLL/small lymphocytic leukemia (SLL) were collected from the authors' archives and published case reports (using PubMed search).
  • Information regarding patient demographics (age, gender), mode of HIV acquisition, HAART use, immunosuppression (HIV Viral load [VL], CD4+ cell count), clinical presentation, pathology, and outcome were abstracted and analyzed.
  • CLL/SLL was diagnosed by lymph node biopsy (n = 1) and/or flow cytometry (n = 5).
  • Two patients remained well without treatment and 4 required therapy due to either hemolytic anemia, CLL- induced renal failure, pancytopenia, or hypogammaglobulinemia with recurrent infections.
  • CONCLUSIONS: CLL/SLL may occur in association with HIV infection in the elderly without significant concomitant immunosuppression.
  • CLL-related complications in our small series were frequent (67%), including mortality (50%).
  • Additional cases of CLL/SLL are anticipated as HIV-infected patients in the HAART era are reported to be living longer.

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  • (PMID = 27961484.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Dillman RO, Schreeder MT, Hon JK, Connelly EF, DePriest C, Cutter K: Community-based phase II trial of pentostatin, cyclophosphamide, and rituximab (PCR) biochemotherapy in chronic lymphocytic leukemia and small lymphocytic lymphoma. Cancer Biother Radiopharm; 2007 Apr;22(2):185-93
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  • [Title] Community-based phase II trial of pentostatin, cyclophosphamide, and rituximab (PCR) biochemotherapy in chronic lymphocytic leukemia and small lymphocytic lymphoma.
  • We conducted a multicenter, community-based phase II trial of PCR biochemotherapy (pentostatin 4 mg/m2, cyclophosphamide 600 mg/m2, and rituximab 375 mg/m2) every 3 weeks for up to 6 cycles in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
  • PCR is active in CLL/SLL, but appears to be less active and associated with more complications in the community setting, compared to trials with younger, lower risk patients who travel to academic referral centers for treatment.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / therapeutic use. Cyclophosphamide / therapeutic use. Delivery of Health Care. Leukemia, Lymphocytic, Chronic, B-Cell / therapy. Pentostatin / therapeutic use

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  • [CommentIn] Cancer Biother Radiopharm. 2007 Oct;22(5):713-4; author reply 715-7 [17979574.001]
  • (PMID = 17600465.001).
  • [ISSN] 1084-9785
  • [Journal-full-title] Cancer biotherapy & radiopharmaceuticals
  • [ISO-abbreviation] Cancer Biother. Radiopharm.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Membrane Glycoproteins; 143891-49-0 / TI 1 protein, Mustela vison; 395575MZO7 / Pentostatin; 4F4X42SYQ6 / Rituximab; 8N3DW7272P / Cyclophosphamide
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17. Ochoa Undargarain O, Hermida Pérez JA, Ochoa Montes de Oca J, Félix León JM: [Well-differentiated lymphocytic lymphoma of the prostate. Case report and bibliographic review]. Arch Esp Urol; 2006 Jun;59(5):538-41
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  • [Title] [Well-differentiated lymphocytic lymphoma of the prostate. Case report and bibliographic review].
  • [Transliterated title] Linfoma linfocítico, bien diferenciado de la próstata, presentación de un caso y breve revisión de la literatura.
  • OBJECTIVE: To report a case of prostate lymphoma and a brief review of the literature.
  • Surgery with retropubic prostatectomy was performed, and pathology revealed a primary prostate lymphoma.
  • The case study is followed by a brief bibliographic review, where we analyse clinical menifestations of this entity, complementary studies useful for diagnosis (laboratory test, trasrectal prostate biopsy, transuretral resection, ultrasound and computerised axial tomography), treatment options (surgery, polychemotherapy, radiotherapy) as well as survival in these patients.
  • CONCLUSIONS: Of the cases reviewed, mean age at diagnosis was 57 years.
  • Clinical debut was with prostate symptoms, with or without AUR and sometimes manifestations of renal failure due to obstructive uropathy, as well as general symptoms (astenia, anorexia, weight loss).
  • PSA values remain unaltered in prostate lymphoma patients.
  • Histologic diagnosis may be made by transrectal prostate biopsy, although transurethral resection (TUR) may be necessary for confirmation.
  • Ultrasound and CT scan are of great utility for diagnosis of both local and distant tumors.
  • From a therapeutic point of view, surgery for the obstruction of the lower urinary tract (TURP or retropubic prostatectomy) may be necessary, as well as the cyclophosphamide based polychemotherapy with corticosteroids and other cytostatic agents, and radiotherapy; intratecal chemotherapy has also been used adjuvant bone marrow transplantation.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 16903560.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 26
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18. Iğdem S, Okkan S, Unalan B, Iğdem A, Ferhanoğlu B: Cervical cancer coexisting with small lymphocytic lymphoma detected during positron emission tomography/computed tomography simulation: a case report. Eur J Gynaecol Oncol; 2008;29(4):405-7
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  • [Title] Cervical cancer coexisting with small lymphocytic lymphoma detected during positron emission tomography/computed tomography simulation: a case report.
  • CASE: A 63-year-old woman who was deemed inoperable due to carcinoma of the cervical stump extending to the parametria and paraaortic lymph nodes detected on MR images presented for extended field radiotherapy.
  • The excisional biopsy was consistent with small lymphocytic lymphoma (SLL).
  • CONCLUSION: In our case, PET/CT simulation not only led to changes in treatment management, but also revealed a very rare coexistence of SLL and invasive squamous cell carcinoma of the cervix.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / radionuclide imaging. Lymphatic Metastasis / radionuclide imaging. Positron-Emission Tomography. Tomography, X-Ray Computed. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Biopsy. Female. Fluorodeoxyglucose F18. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging / methods. Neoplasms, Second Primary / radiography. Neoplasms, Second Primary / radionuclide imaging. Radiopharmaceuticals. Whole Body Imaging / methods


19. Fehr M, Templeton A, Cogliatti S, Aebersold F, Egli F, Gillessen S, Cathomas R: Primary manifestation of small lymphocytic lymphoma in the prostate. Onkologie; 2009 Oct;32(10):586-8
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  • [Title] Primary manifestation of small lymphocytic lymphoma in the prostate.
  • BACKGROUND: Infiltration of non-haematopoietic organs by small lymphocytic lymphoma/chronic lymphocytic leukaemia (SLL/CLL) is not unusual in late-stage disease and thus quite frequently encountered in post-mortem examinations.
  • However, primary manifestation of SLL/CLL in the prostate is rarely diagnosed.
  • PATIENTS AND METHODS: We report two cases of primary prostatic SLL/CLL, in one case in combination with prostate carcinoma, and discuss diagnostic pitfalls, pathophysiological mechanisms and therapeutic management, together with an overview of the literature.
  • CONCLUSIONS: Lymphocytic infiltration of the prostate associated with obstructive symptoms is rare but can already occur in very early disease.
  • Microscopically, SLL/CLL infiltration can be distinguished from chronic prostatitis by its pattern of infiltration and by immunohistochemistry.
  • As the incidence of both SLL/CLL and prostatic carcinoma increases with age, composite tumours might occur more often in the future.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / therapy. Prostatic Neoplasms / pathology. Prostatic Neoplasms / therapy

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] Onkologie. 2009 Oct;32(10):550-1 [19816069.001]
  • (PMID = 19816076.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 17
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20. Tsai HT, Cross AJ, Graubard BI, Oken M, Schatzkin A, Caporaso NE: Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies. Cancer Epidemiol Biomarkers Prev; 2010 Oct;19(10):2680-4
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  • [Title] Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies.
  • BACKGROUND: Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown.
  • METHODS: Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk.
  • Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up.
  • RESULTS: We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL.
  • We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36).
  • CONCLUSION: We did not find any associations between food or nutrient intake and CLL/SLL.
  • IMPACT: Our large prospective study indicates that diet may not play a role in CLL/SLL development.
  • [MeSH-major] Diet. Leukemia, Lymphocytic, Chronic, B-Cell / epidemiology

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  • [Copyright] ©2010 AACR.
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  • (PMID = 20929883.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010152-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS231483; NLM/ PMC3501724
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21. Rabascio C, Laszlo D, Andreola G, Saronni L, Radice D, Rigacci L, Fabbri A, Frigeri F, Calabrese L, Billio A, Bertolini F, Martinelli G: Expression of the human concentrative nucleotide transporter 1 (hCNT1) gene correlates with clinical response in patients affected by Waldenström's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) undergoing a combination treatment with 2-chloro-2'-deoxyadenosine (2-CdA) and Rituximab. Leuk Res; 2010 Apr;34(4):454-7
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  • [Title] Expression of the human concentrative nucleotide transporter 1 (hCNT1) gene correlates with clinical response in patients affected by Waldenström's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) undergoing a combination treatment with 2-chloro-2'-deoxyadenosine (2-CdA) and Rituximab.
  • In vitro studies of resistant human cell lines have confirmed that human concentrative nucleoside transporter 1 (hCNT1)-deficient cells display resistance.
  • EXPERIMENTAL DESIGN: We applied real-time PCR method to assess the mRNA expression of equilibrative and concentrative nucleoside transporter (hENT1, hCNT1), deoxycytidine and deoxyguanosine kinase (dCK, dGK), 5'-nucleotidase (5'-NT), ribonucleotide reductase catalytic and regulatory (RR1, RR2) subunits in bone marrow cells from 32 patients with Waldenström's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) who received 2CdA-based chemotherapy.
  • RESULTS: All 32 patients enrolled expressed lower levels of hCNT1 as compared to healthy donors.
  • In univariate analysis, lower expression level of hCNT1 (p=0.0021) and RR2 (p=0.02) correlated with response to chemotherapy.
  • In particular, patients with low levels of hCNT1 achieved inferior clinical response.
  • This study suggests that nucleotidase expression levels can be used to identify subgroups of WM and SLL patients who will likely respond differently to a 2CdA-based therapy.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cladribine / administration & dosage. Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy. Membrane Transport Proteins / genetics. Waldenstrom Macroglobulinemia / drug therapy

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19647871.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Transport Proteins; 0 / cif nucleoside transporter; 47M74X9YT5 / Cladribine; 4F4X42SYQ6 / Rituximab
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22. Tsimberidou AM, Wen S, O'Brien S, McLaughlin P, Wierda WG, Ferrajoli A, Faderl S, Manning J, Lerner S, Mai CV, Rodriguez AM, Hess M, Do KA, Freireich EJ, Kantarjian HM, Medeiros LJ, Keating MJ: Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center. J Clin Oncol; 2007 Oct 10;25(29):4648-56
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  • [Title] Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center.
  • PURPOSE: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are currently considered the same entity, but controversy remains over whether CLL and SLL should be treated similarly.
  • We assessed whether characteristics of patients with CLL and SLL differ in ways other than the absolute lymphocyte count (ALC) and evaluated treatment outcomes and prognostic factors.
  • METHODS: We searched the electronic database for patients with CLL or SLL who presented to The University of Texas M.D.
  • RESULTS: Among 2,126 consecutive CLL/SLL patients, 312 (15%) had ALC less than 5 x 10(9)/L.
  • CONCLUSION: Patients with CLL or SLL can be treated similarly.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Lymphocyte Count
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD38 / biosynthesis. Diagnosis, Differential. Disease-Free Survival. Humans. Middle Aged. Prognosis. Texas. Treatment Outcome

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  • (PMID = 17925562.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.5 / Antigens, CD38
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23. Hainsworth JD, Vazquez ER, Spigel DR, Raefsky E, Bearden JD, Saez RA, Greco FA: Combination therapy with fludarabine and rituximab followed by alemtuzumab in the first-line treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase 2 trial of the Minnie Pearl Cancer Research Network. Cancer; 2008 Mar 15;112(6):1288-95
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  • [Title] Combination therapy with fludarabine and rituximab followed by alemtuzumab in the first-line treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase 2 trial of the Minnie Pearl Cancer Research Network.
  • BACKGROUND: The purpose of the current study was to evaluate the efficacy and toxicity of the combination of fludarabine and rituximab, followed by alemtuzumab, as first-line treatment for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
  • METHODS: In a nonrandomized phase 2 trial, 41 patients who had previously untreated CLL or SLL and required treatment received 4 cycles of the fludarabine and rituximab combination followed 5 weeks later by 4 weeks (12 doses) of intravenous alemtuzumab therapy.
  • RESULTS: Initial treatment with the combination of fludarabine and rituximab was well tolerated, and produced a 71% overall response rate (13% complete response).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antibodies, Monoclonal, Murine-Derived. Antibodies, Neoplasm / administration & dosage. Disease-Free Survival. Female. Humans. Male. Maximum Tolerated Dose. Middle Aged. Rituximab. Survival Rate. Vidarabine / administration & dosage. Vidarabine / analogs & derivatives

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  • [Copyright] Copyright (c) 2008 American Cancer Society.
  • (PMID = 18189296.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antibodies, Neoplasm; 3A189DH42V / alemtuzumab; 4F4X42SYQ6 / Rituximab; FA2DM6879K / Vidarabine; P2K93U8740 / fludarabine
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24. Li S, Mann KP, Holden JT: Composite small lymphocytic lymphoma and extra-medullary myeloid tumor: a potential diagnostic pitfall. Int J Clin Exp Pathol; 2008;1(1):91-7
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  • [Title] Composite small lymphocytic lymphoma and extra-medullary myeloid tumor: a potential diagnostic pitfall.
  • Reported herein is a case of composite small lymphocytic lymphoma (SLL) and extramedullary myeloid tumor (EMT) occurring in the same lymph node.
  • Routine morphologic examination revealed a diffuse proliferation of small mature lymphocytes with numerous irregularly dispersed nodules, closely resembling SLL with prominent proliferation centers or Richter's transformation.
  • Flow cytometric immunophenotyping and immunohistochemical stains demonstrated the presence of SLL cells as well as myeloblasts, confirming the diagnosis of a composite SLL and EMT.
  • In conclusion, the occurrence of SLL and EMT in the same lymph node is rare and multiparameter approach is essential for a definitive diagnosis.

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  • (PMID = 18784827.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480536
  • [Keywords] NOTNLM ; Extramedullary myeloid tumor / flow cytometric immunophenotyping / fluorescence in situ hybridization / immunohistochemistry / karyotype / small lymphocytic lymphoma
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25. Iczkowski KA, Gapin TB, Wajsman Z: Small lymphocytic lymphoma involving an enlarging complex renal cyst. Arch Pathol Lab Med; 2005 Jan;129(1):111-2
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  • [Title] Small lymphocytic lymphoma involving an enlarging complex renal cyst.
  • Cervical lymph node biopsy had revealed small lymphocytic lymphoma.
  • Computed tomographic scan disclosed diffuse mesenteric and retroperitoneal adenopathy consistent with chronic lymphocytic leukemia, as well as a 4.5-cm complex cystic right renal mass, which 17 months later enlarged to 6.2 cm.
  • Partial nephrectomy revealed infiltration of the cyst wall by small lymphocytic lymphoma.
  • To our knowledge, this is the first reported case of lymphoma arising in or colonizing a renal cyst.
  • [MeSH-major] Kidney Diseases, Cystic / complications. Kidney Neoplasms / complications. Leukemia, Lymphocytic, Chronic, B-Cell / complications

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  • (PMID = 15628890.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Kim T, Grobmyer SR, Dixon LR, Allan RW, Hochwald SN: Autoimmune pancreatitis and concurrent small lymphocytic lymphoma: not just a coincidence? J Gastrointest Surg; 2008 Sep;12(9):1566-70
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  • [Title] Autoimmune pancreatitis and concurrent small lymphocytic lymphoma: not just a coincidence?
  • Computed tomography imaging revealed fullness of the pancreatic head and multiple enlarged retroperitoneal lymph nodes.
  • Several enlarged lymph nodes in the aortocaval region and a firm hard mass in the pancreatic head were found.
  • Frozen section from one of the lymph nodes was suspicious for low-grade lymphoma.
  • The retroperitoneal lymph nodes were involved by small lymphocytic lymphoma.
  • DISCUSSION: Autoimmune pancreatitis is the most common benign diagnosis after pancreatic resection for presumed malignancy.
  • It has a well-documented association with autoimmune conditions, such as Sjögren's syndrome, inflammatory bowel disease, and sclerosing cholangitis.
  • Additionally, chronic lymphocytic leukemia-small lymphocytic lymphoma is often associated with autoimmune phenomena, most notably autoimmune hemolytic anemia.
  • However, an association between autoimmune pancreatitis and small lymphocytic lymphoma has not been previously described.
  • To our knowledge, this is the first reported case of a patient with concurrent autoimmune pancreatitis and small lymphocytic lymphoma.
  • [MeSH-major] Autoimmune Diseases / complications. Autoimmune Diseases / diagnosis. Leukemia, Lymphocytic, Chronic, B-Cell / complications. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Pancreatitis / complications. Pancreatitis / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Blood Chemical Analysis. Cholangiography. Follow-Up Studies. Humans. Immunohistochemistry. Jaundice / diagnosis. Jaundice / etiology. Male. Pancreatic Function Tests. Pancreaticoduodenectomy / methods. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18506547.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Woyach JA, Lin TS, Lucas MS, Heerema N, Moran ME, Cheney C, Lucas DM, Wei L, Caligiuri MA, Byrd JC: A phase I/II study of rituximab and etanercept in patients with chronic lymphocytic leukemia and small lymphocytic lymphoma. Leukemia; 2009 May;23(5):912-8
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  • [Title] A phase I/II study of rituximab and etanercept in patients with chronic lymphocytic leukemia and small lymphocytic lymphoma.
  • Rituximab has modest activity in relapsed chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma but is associated with tumor necrosis factor-alpha (TNF-alpha) release that can cause CLL proliferation and inhibit apoptosis.
  • The combination of etanercept and thrice weekly rituximab produces durable remissions in non-del(17p13.1) CLL patients and is well tolerated.

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  • (PMID = 19225537.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA095426; United States / NCI NIH HHS / CA / P01 CA9542
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; 4F4X42SYQ6 / Rituximab; FA2DM6879K / Vidarabine; OP401G7OJC / Etanercept; P2K93U8740 / fludarabine
  • [Other-IDs] NLM/ NIHMS79899; NLM/ PMC4099250
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28. Hauswirth AW, Födinger M, Fritz M, Müllauer L, Simonitsch-Klupp I, Streubel B, Chott A, Sperr WR, Jäger U, Valent P: Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease. Hum Pathol; 2008 Jun;39(6):917-24
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  • [Title] Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease.
  • Patients with systemic mastocytosis (SM) may acquire an associated hematologic non-mast cell (MC)-lineage disease (AHNMD).
  • In most cases, a myeloid neoplasm is diagnosed, whereas the occurrence of a lymphoproliferative disease is an extremely rare event.
  • We report on a patient with indolent SM associated with small lymphocytic lymphoma (SLL).
  • The patient presented with lymphadenopathy, maculopapular exanthema, and elevated serum tryptase.
  • The bone marrow biopsy showed focal MC aggregates together with SLL.
  • As assessed by immunostaining, neoplastic MC were found to exhibit CD117 and CD25 but did not display CD5 or CD20, whereas SLL cells were found to coexpress CD5 and CD20 but did not express MC antigens.
  • The KIT mutation D816V was detected in sorted CD34(+) cells and unfractionated marrow cells but not in CD5(+) SLL cells, confirming the coexistence of 2 distinct neoplasms.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Mastocytosis, Systemic / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / metabolism. Bone Marrow Cells / metabolism. Bone Marrow Cells / pathology. DNA Mutational Analysis. DNA, Neoplasm / analysis. Flow Cytometry. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism. Treatment Outcome

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  • (PMID = 18448146.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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29. Soria-Céspedes D, Baquera-Heredia J, Pardo A, Ortiz-Hidalgo C: [Bilateral tonsillar hypertrophy as the first manifestation of B cell-small lymphocytic lymphoma with interfolicular pattern]. Rev Med Inst Mex Seguro Soc; 2010 Jan-Feb;48(1):75-8

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  • [Title] [Bilateral tonsillar hypertrophy as the first manifestation of B cell-small lymphocytic lymphoma with interfolicular pattern].
  • [Transliterated title] Hipertrofia amigdalina bilateral como primera manifestación de linfoma de linfocitos pequeños B con patrón interfolicular.
  • B-cell small lymphocytic lymphoma typically involves nodal or extranodal tissues as a diffuse proliferation with proliferation centers (pseudofollicules) obliterating normal architecture.
  • But there are unusual patterns of involvement including interfollicular pattern that can be difficult to recognize histologically and probably represent partial or early involvement by neoplasm.
  • Tonsillar lymphoma usually presents either as a unilaterally enlarged palatine tonsil or as an ulcerative and fungating lesion over the tonsillar area.
  • Most lymphomas that involve the tonsil are diffuse large B cell lymphomas and primary low-grade lymphomas are exceptional.
  • We present a primary B-cell small lymphocytic lymphoma affecting palatine tonsils with interfollicular pattern in a 54 year-old man that clinically presented with symmetric / bilateral tonsillar enlargement and sleep apnea.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Lymphoma, B-Cell / diagnosis

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  • (PMID = 20696111.001).
  • [ISSN] 0443-5117
  • [Journal-full-title] Revista médica del Instituto Mexicano del Seguro Social
  • [ISO-abbreviation] Rev Med Inst Mex Seguro Soc
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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30. McElroy C, Velilla R, Chaudhary H, Al-Abbadi MA: Fine-needle aspiration diagnosis of squamous cell carcinoma in a lymph node involved with small lymphocytic lymphoma: case report and review of the literature. Diagn Cytopathol; 2009 Jan;37(1):48-50
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  • [Title] Fine-needle aspiration diagnosis of squamous cell carcinoma in a lymph node involved with small lymphocytic lymphoma: case report and review of the literature.
  • Diagnosis of two distinct malignant entities existing concurrently and at the same location (synchronous malignancy) by fine- needle aspiration (FNA) is unusual but may occur.
  • Small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) in particular is associated with an increased incidence of secondary tumor, likely due to associated immunodeficiency.
  • Co-occurrence of some carcinomas such as squamous cell carcinoma (SCC), may show especially aggressive behavior.
  • A 57-year-old Caucasian male presented with recurrent upper extremity lymphedema and diffuse lymphadenopathy of the axillary and cervical regions.
  • FNA of a large cervical lymph node was diagnostic for both atypical lymphocytic proliferation and SCC.
  • Flow cytometric analysis showed the atypical lymphocytic proliferation to be positive for CD5, CD23, CD19, CD20, HLA-DR, CD38, and the population was kappa light chain restricted.
  • These cells were negative for CD-10 and FMC-7 antigens, suggesting a phenotype of B-cell SLL/CLL.
  • We report a rare occurrence of metastatic SCC to a lymph node infiltrated by SLL/CLL.
  • The diagnosis was achieved by a combination of cytomorphologic examination of FNA smears, immunohistochemical staining of cell block material, and flow cytometry on the sample obtained by FNA.
  • To the best of our knowledge, only three cases of SCC metastasis to SLL/CLL diagnosed by FNA have been reported in the English literature.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Lymph Nodes / pathology. Neoplasms, Multiple Primary / diagnosis. Oropharyngeal Neoplasms / pathology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18973126.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 16
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31. Steinmetz C, Shabaik A, Hasteh F: Systemic mastocytosis associated with small lymphocytic lymphoma: an incidental finding in a patient with invasive gastric adenocarcinoma. Diagn Cytopathol; 2007 Nov;35(11):728-33
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  • [Title] Systemic mastocytosis associated with small lymphocytic lymphoma: an incidental finding in a patient with invasive gastric adenocarcinoma.
  • We report an interesting case of systemic mastocytosis diagnosed incidentally in an omental lymph node in the setting of an invasive gastric adenocarcinoma.
  • The Diff-Quick touch preparation of the lymph node revealed abundant single cells and loose aggregates of cells with round to oval nuclei and deeply basophilic granules.
  • Monotonous proliferation of small mature lymphocytes and many eosinophils were also present in the background.
  • The frozen section and permanent sections of lymph node showed partial to complete replacement of lymph node by neoplastic mast cells.
  • [MeSH-major] Adenocarcinoma / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Mastocytosis, Systemic / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology


32. Leuenberger M, Frigerio S, Wild PJ, Noetzli F, Korol D, Zimmermann DR, Gengler C, Probst-Hensch NM, Moch H, Tinguely M: AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations. Mod Pathol; 2010 Feb;23(2):177-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations.
  • The biological behavior of chronic lymphocytic leukemia and small lymphocytic lymphoma is unpredictable.
  • Nonetheless, non-mutated IgV(H) gene rearrangement, ATM (11q22-23) and p53 (17p13) deletion are recognized as unfavorable prognosticators in chronic lymphocytic leukemia.
  • The mRNA expression of activation-induced cytidine deaminase (AID), an enzyme indispensable for somatic hypermutation processes, was claimed to be predictive of non-mutated chronic lymphocytic leukemia cells in blood.
  • Here, we evaluated AID protein expression compared with known molecular and immunohistochemical prognostic indicators in 71 chronic lymphocytic leukemia/small lymphocytic lymphoma patients using a tissue microarray approach.
  • Twenty-five percent (17/69) of patients with AID-positive chronic lymphocytic leukemia/small lymphocytic lymphoma displayed a shorter survival than AID-negative chronic lymphocytic leukemia/small lymphocytic lymphoma patients (61 vs 130 months, P=0.001).
  • Taken together, our study shows that AID expression is an indicator of an unfavorable prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma patients, although it is not a surrogate marker for the IgV(H) status.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cytidine Deaminase / biosynthesis. Leukemia, Lymphocytic, Chronic, B-Cell / enzymology. Leukemia, Lymphocytic, Chronic, B-Cell / genetics

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  • (PMID = 19898425.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Immunoglobulin Heavy Chains; 0 / Immunoglobulin Variable Region; EC 3.5.4.- / AICDA (activation-induced cytidine deaminase); EC 3.5.4.5 / Cytidine Deaminase
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33. El Demellawy D, Ross C, Sur M, Alowami S: Synchronously diagnosed lymph nodal collision tumor of malignant melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: case report. Diagn Pathol; 2007;2:34
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  • [Title] Synchronously diagnosed lymph nodal collision tumor of malignant melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: case report.
  • We report a case of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma and malignant melanoma (MM) occurring synchronously in the same lymph node.
  • To our knowledge this is the first time that synchronous occurrence of these two malignant processes in the same tissue is described.
  • In this case it is important that the melanoma was recognized in the excised lymph node, as this finding had much more critical treatment and long term survival consequences.

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  • (PMID = 17760975.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2040134
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34. Ding W, Zent CS: Diagnosis and management of autoimmune complications of chronic lymphocytic leukemia/ small lymphocytic lymphoma. Clin Adv Hematol Oncol; 2007 Apr;5(4):257-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of autoimmune complications of chronic lymphocytic leukemia/ small lymphocytic lymphoma.
  • Autoimmune cytopenia is an important but poorly understood clinical complication of chronic lymphocytic leukemia/ small lymphocytic lymphoma.
  • We review the pathogenesis, clinical presentation, and management of autoimmune hemolytic anemia, immune thrombocytopenia, and pure red blood cell aplasia in patients with chronic lymphocytic leukemia/ small lymphocytic lymphoma.
  • [MeSH-major] Agranulocytosis / diagnosis. Anemia, Hemolytic, Autoimmune / diagnosis. Leukemia, Lymphocytic, Chronic, B-Cell. Purpura, Thrombocytopenic, Idiopathic / diagnosis. Red-Cell Aplasia, Pure / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male

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  • (PMID = 17607284.001).
  • [ISSN] 1543-0790
  • [Journal-full-title] Clinical advances in hematology & oncology : H&O
  • [ISO-abbreviation] Clin Adv Hematol Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA97274
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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35. Peinert S, Seymour JF: Indolent lymphomas other than follicular and marginal zone lymphomas. Hematol Oncol Clin North Am; 2008 Oct;22(5):903-40, viii
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  • [Title] Indolent lymphomas other than follicular and marginal zone lymphomas.
  • This article addresses two of the less common entities among clinically indolent B-cell non-Hodgkin lymphomas: small lymphocytic lymphoma and lymphoplasmacytic lymphoma, also known as "Waldenstrom's macroglobulinemia."
  • Differential diagnoses and prognostic factors are discussed for each as well as new treatment options and stem cell transplantation.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / therapy. Stem Cell Transplantation. Waldenstrom Macroglobulinemia / pathology. Waldenstrom Macroglobulinemia / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Prognosis

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  • (PMID = 18954743.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 265
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36. Ertekin V, Orbak Z, Selimoglu MA, Yildiz L: Serum leptin levels in childhood celiac disease. J Clin Gastroenterol; 2006 Nov-Dec;40(10):906-9
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  • [Title] Serum leptin levels in childhood celiac disease.
  • OBJECTIVE: Leptin has effects on growth and is also involved in immune regulation.
  • We thought that with its intestinal histopathologic alterations due to immune mechanisms, and subsequent malnutrition and/or growth failure, celiac disease (CD) deserves interest regarding leptin status.
  • METHOD: Serum leptin levels of 19 children with CD on admission and 1 year after gluten-free diet (GFD) and of 16 healthy children were determined.
  • Mean serum leptin level of children with CD on admission and of healthy children were 1.60+/-0.63 ng/mL, and 3.98+/-1.49 ng/mL, respectively (P: 0.0001).
  • Mean serum leptin level under GFD was 4.55+/-1.97 ng/mL.
  • There was a statistical significant difference between serum levels determined before and 1 year after GFD (P: 0.001) and between those of under GFD and healthy children (P: 0.001).
  • Mean serum leptin level of children with Marsh IIIc and Marsh IIIa were not different (1.70+/-0.73 ng/mL vs. 1.45+/-0.59 ng/mL).
  • Leptin was correlated with body mass index in healthy children, and in CD both before and after GFD (P<0.001).
  • Serum leptin level was not correlated with lumbar z score either before or after GFD.
  • CONCLUSIONS: Serum leptin level is affected in childhood CD, it is not directly related to histopathologic findings, and is responsive to GFD.
  • Further studies investigating its level in different clinical and histopathologic presentations might give clear clues about the role of leptin in CD.
  • [MeSH-major] Celiac Disease / blood. Leptin / blood

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  • (PMID = 17063109.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin; 8002-80-0 / Glutens
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37. Sullu Y, Donmez G, Kandemir B, Gun S: Renal cell carcinoma with non-Hodgkin's lymphoma infiltration: a case report. Pathol Res Pract; 2007;203(8):625-7
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  • [Title] Renal cell carcinoma with non-Hodgkin's lymphoma infiltration: a case report.
  • The coexistence of renal cell carcinoma and non-Hodgkin's lymphoma is more common than expected in the general population; however, renal cell carcinoma with infiltration by non-Hodgkin's lymphoma has rarely been reported.
  • Here we report on a 77-year-old patient who presented with small lymphocytic lymphoma in the jugulodigastric lymph node.
  • On histopathological examination, the mass was diagnosed as a grade III renal cell carcinoma with infiltrated small lymphocytic lymphoma that was positive for B-cells (CD20).
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Lymphoma, B-Cell / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17662539.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD20
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38. Unal M, Eskandari G, Muşlu N, Pata YS, Akbaş Y: Serum leptin levels in patients with allergic rhinitis. Otolaryngol Head Neck Surg; 2006 Feb;134(2):331-3
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  • [Title] Serum leptin levels in patients with allergic rhinitis.
  • OBJECTIVE: To investigate the serum leptin levels in patients with allergic rhinitis during the symptomatic period.
  • RESULTS: Leptin levels were 28.8 +/- 14.1 ng/mL in the patients with allergic rhinitis, and 20.8 +/- 13.5 ng/mL in the control group respectively.
  • CONCLUSION: Serum leptin levels were found to be significantly higher in patients with allergic rhinitis in symptomatic period.
  • SIGNIFICANCE: Apart from its primary role in the regulation of body weight and energy expenditure, leptin may have a role in the inflammatory process of the allergic rhinitis.
  • [MeSH-major] Leptin / blood. Rhinitis / blood

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  • (PMID = 16455387.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin
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39. Kiselow MA, Rassnick KM, McDonough SP, Goldstein RE, Simpson KW, Weinkle TK, Erb HN: Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). J Am Vet Med Assoc; 2008 Feb 1;232(3):405-10
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  • [Title] Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005).
  • OBJECTIVE: To evaluate factors associated with response to treatment, remission duration, and survival in cats with low-grade lymphoma affecting various organ systems.
  • SAMPLE POPULATION: 41 cats with histologically confirmed low-grade lymphocytic lymphoma.
  • PROCEDURES: Medical records and biopsy specimens of cats with histologically confirmed low-grade lymphocytic lymphoma of various organ systems treated with prednisone and chlorambucil between 1995 and 2005 were reviewed.
  • Seventy-eight percent of cats tested had low serum cobalamin concentrations.
  • Lymphoma was confined to the gastrointestinal tract in 68% of cats.
  • CONCLUSIONS AND CLINICAL RELEVANCE: Most cats with lymphocytic lymphoma responded to treatment with prednisone and chlorambucil, and most factors evaluated were not associated with outcome.
  • [MeSH-major] Cat Diseases / drug therapy. Chlorambucil / therapeutic use. Leukemia, Lymphocytic, Chronic, B-Cell / veterinary. Prednisone / therapeutic use. Remission Induction

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  • (PMID = 18241108.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Hormonal; 18D0SL7309 / Chlorambucil; VB0R961HZT / Prednisone
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40. Daudignon A, Poulain S, Morel P, Penther D, Parmentier F, Bouchindhomme B, Fernandes J, Duthilleul P, Bastard C: Increased trisomy 12 frequency and a biased IgVH 3-21 gene usage characterize small lymphocytic lymphoma. Leuk Res; 2010 May;34(5):580-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased trisomy 12 frequency and a biased IgVH 3-21 gene usage characterize small lymphocytic lymphoma.
  • Small lymphocytic lymphoma (SLL) and chronic lymphocytic leukemia (CLL) are considered as similar entity by the WHO classification.
  • We assessed the distribution of the four prognostic cytogenetic markers (deletion 11q23, 13q14, 17p13 and trisomy 12) and VH mutational status in 32 SLL and 119 CLL.
  • Trisomy 12 was most frequent (36% vs 13%, p=0.014) and 13q14 deletion was less frequent (9% vs 44%, p=0.001) in SLL in comparison with CLL.
  • An over representation of VH3-21 gene usage was found in SLL (17% vs 1%, p=0.011).
  • In conclusion, SLL show specific genetic markers that distinguish them from classical CLL.
  • [MeSH-major] Biomarkers, Tumor / genetics. Chromosomes, Human, Pair 12 / genetics. Genes, Immunoglobulin Heavy Chain / genetics. Immunoglobulin Variable Region / genetics. Leukemia, Lymphocytic, Chronic, B-Cell / genetics. Trisomy / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Mutational Analysis. Female. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Male. Middle Aged. Mutation. Neoplasm Staging

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19959229.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Immunoglobulin Variable Region
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41. Atmaca M, Tezcan E, Kuloglu M, Ustundag B: Serum leptin levels in obsessive-compulsive disorder. Psychiatry Clin Neurosci; 2005 Apr;59(2):189-93
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  • [Title] Serum leptin levels in obsessive-compulsive disorder.
  • The aim of the present study was to evaluate serum leptin levels to demonstrate whether or not its eventual alterations might have an etiopathogenetic significance in patients with obsessive-compulsive disorder (OCD).
  • Thus, it was planned to examine whether serum leptin levels were affected by pure OCD (OCD-D), pure depression (D) or the comorbidity of OCD and depression (OCD+D).
  • Forty-four patients with OCD (27 with OCD-D and 17 with OCD+D), 38 depressed patients and 30 control subjects were enrolled and serum leptin and cortisol levels were measured.
  • According to the mean leptin levels, no significant difference was found between the OCD-D and control groups and between the OCD+D and D groups, while statistically significantly lower levels were found in the OCD+D and D groups than in control group.
  • Significant difference in the mean leptin levels was found among groups even after controlling for body mass index or sex.
  • The present study confirms the strong relationship between serum leptin and cortisol values and suggests that reduced leptin levels, rather than having an etiopathogenetic significance in patients with OCD, seem to be associated with patients with OCD and depression but not with pure OCD patients, and that OCD may be a heterogeneous subtype containing some biological indications of anxiety and affective disorders.
  • [MeSH-major] Leptin / blood. Obsessive-Compulsive Disorder / blood
  • [MeSH-minor] Adolescent. Adult. Depressive Disorder / blood. Depressive Disorder / complications. Female. Humans. Hydrocortisone / blood. Male. Middle Aged. Reference Values

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  • (PMID = 15823166.001).
  • [ISSN] 1323-1316
  • [Journal-full-title] Psychiatry and clinical neurosciences
  • [ISO-abbreviation] Psychiatry Clin. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Leptin; WI4X0X7BPJ / Hydrocortisone
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42. Okulicz JF, Lloyd BA, Krause JO, Conger NG: Mycobacterium tuberculosis infection of a presumed Charcot joint. South Med J; 2005 Sep;98(9):924-6
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  • A 65-year-old male with peripheral neuropathy and small lymphocytic lymphoma presented with erythema and edema of the left foot.
  • [MeSH-major] Arthropathy, Neurogenic / diagnosis. Diagnostic Errors. Mycobacterium tuberculosis / isolation & purification. Tuberculosis, Osteoarticular / diagnosis. Tuberculosis, Osteoarticular / microbiology
  • [MeSH-minor] Aged. Antitubercular Agents / therapeutic use. Drug Therapy, Combination. Foot Ulcer / drug therapy. Foot Ulcer / microbiology. Humans. Leukemia, Lymphocytic, Chronic, B-Cell / complications. Male. Peripheral Nervous System Diseases / complications. Synovial Fluid / microbiology

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  • (PMID = 16217986.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents
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43. Asaad NY, Abd El-Wahed MM, Dawoud MM: Diagnosis and prognosis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL). J Egypt Natl Canc Inst; 2005 Dec;17(4):279-90
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  • [Title] Diagnosis and prognosis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL).
  • BACKGROUND: B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL) show many overlapping morphologic and immunophenotyping features, however they have great difference in therapeutic regimens and prognosis.
  • THE AIM OF THE STUDY: Is to determine the diagnostic and prognostic role of clinico-pathologic variables, CD23 and Cyclin D1 oncoprotiens in B-SLL/CLL and MCL.
  • PATIENTS AND METHODS: This study included 25 BCLL/ SLL cases and 25 MCL cases.
  • RESULTS: There was significant difference between BCLL/ SLL and MCL regarding several items including pattern of growth, where interfollicular pattern was restricted to B-SLL/CLL while nodular and mantle zone pattern were confined to MCL; pseudo-follicles were only present in B-CLL/SLL.
  • Transformed cells, plasmacytoid cells, peripheral blood lymphocytosis, significant longer survival and good prognosis were statistically more prominent in favor of B-CLL/SLL.
  • On the other hand, cell cleavage, epithelioid histiocytes, plasma cells, naked nuclei, hyalinized venules, deposited hyaline material in background and reticular fibers in addition to higher mitotic index per 20 HPF were more significantly identified in favor of MCL.
  • CD23 was expressed as membranous pattern in 16/25 (64%) of B-CLL/SLL cases and 1/25 (4%) of MCL cases.
  • On the other hand, Cyclin D1 was expressed as nuclear staining in 18/25 (72%) of MCL cases and only 1/25 (4%) of B-CLL/SLL cases.
  • Regarding B-CLL/SLL, age >60 years and mitosis >or=10/20 HPF were independent prognostic factors of shorter survival by multivariate analysis.
  • CONCLUSION: Cyclin D1 is not only implicated in tumor genesis of MCL, but also in progression and extension of the disease when expressed in high levels (50% cut off value) and it seems to have prognostic impact in MCL.
  • This can be used as a basis for future therapeutic strategies targeting cell cycle regulators.
  • This study could support the concept that Cyclin D1 and CD23 immunostaining may be reliable diagnostic tools for discrimination between B-CLL/SLL and MCL.
  • [MeSH-major] Biomarkers, Tumor / analysis. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Lymphoma, Mantle-Cell / diagnosis
  • [MeSH-minor] Cyclin D1 / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Middle Aged. Prognosis. Receptors, IgE / metabolism. Survival Analysis


44. Baig M, Azhar A, Zaidi P, Kamal S, Karira K: Serum leptin level in hypothyroid males. J Coll Physicians Surg Pak; 2005 Dec;15(12):757-60
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  • [Title] Serum leptin level in hypothyroid males.
  • OBJECTIVE: To determine the correlation of serum leptin with thyroid hormones in primary hypothyroid male patients and euthyroid lean and obese control subjects.
  • Serum leptin was measured by ELISA and FT4, FT3 and TSH were measured by radioimmunoassay (RIA), triacylglycerol (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) by kit method, low density lipoprotein cholesterol (LDL-C) was calculated by the Friedwald s formula, and fasting blood sugar (FBS) by glucose oxidase method.
  • RESULTS: The mean +/- SEM values of leptin in male hypothyroid patients were 10.71+/-2.5 ng/ml, 8.27+/-1.91 in control group and 21.34+/-3.4 ng/ml in obese group, respectively.
  • No significant difference was found in serum leptin levels between hypothyroid patients and their age, BMI matched control group, while obese control group had significantly higher values of leptin (<0.05).
  • There was no significant correlation of leptin found with T4, T3, and TSH in hypothyroid patients and lean and obese control subjects.
  • This study observed that serum leptin level was significantly correlated with the BMI (r = 0.732, p < 0.005, r = 0.783, p < 0.005, r = 0.653, p < 0.005), in normal lean, obese and hypothyroid male patients respectively.
  • CONCLUSION: The results of this study suggest that there is no correlation between serum leptin and thyroid hormones in hypothyroid patients as well as in euthyroid subjects.
  • Serum leptin is directly related with BMI.
  • [MeSH-major] Hypothyroidism / blood. Leptin / blood

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  • (PMID = 16398964.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Leptin; 0 / Thyroid Hormones
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45. Aliustaoglu M, Bilici A, Gumus M, Colak AT, Baloglu G, Irmak R, Seker M, Ustaalioglu BB, Salman T, Sonmez B, Salepci T, Yaylaci M: Preoperative serum leptin levels in patients with breast cancer. Med Oncol; 2010 Jun;27(2):388-91
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  • [Title] Preoperative serum leptin levels in patients with breast cancer.
  • Leptin is an adipocyte-derived protein and plays an important role in the control of body weight by acting as a neurohormone regulating energy balance and food intake in the hypothalamus.
  • The high serum leptin levels and the overexpression of leptin receptors have been documented in breast cancer patients, but the levels never checked preoperatively.
  • In the present study, the relationship between preoperative serum leptin levels of the breast cancer patients and the healthy controls were evaluated.
  • The serum leptin levels in 30 breast cancer patients were compared to 30 healthy female volunteers.
  • In addition, the association of serum leptin levels and the various well-known risk factors were studied.
  • Serum leptin levels of patients with breast cancer (28.55 + 19.7 ng/ml) were tended to be higher than those of controls (26.43 + 19.4 ng/ml), but it did not reach statistical difference (P = 0.712).
  • There was significant correlation between the expression of ER, PR, and serum leptin levels (P = 0.018 and 0.037, respectively), but not with the HER-2/neu receptor expression (P = 0.067).
  • Also association was not found between the tumor size, lymph node involvement, and the levels of serum leptin (P = 0.235, 0.34, and 0.86, respectively).
  • The serum leptin level was also found to be similar in premenopausal (24.85 +/- 18.14 ng/ml) and postmenopausal (30.49 +/- 17.19 ng/ml) patients (P = 0.235).
  • The preoperative serum leptin levels in breast cancer patients were similar to healthy controls.
  • In subset analysis, the significant correlation between the leptin level and hormonal status was noted, but association with HER-2/neu was not detected.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Breast Neoplasms / surgery. Leptin / blood. Preoperative Care

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  • (PMID = 19412673.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Leptin
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46. Xerri L, Chetaille B, Serriari N, Attias C, Guillaume Y, Arnoulet C, Olive D: Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Hum Pathol; 2008 Jul;39(7):1050-8
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  • [Title] Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia.
  • PD-1 expression was recently reported in some T-cell non-Hodgkin lymphoma (NHL) subtypes, but the expression profile of PD-1 and its ligands (PD-L1 and PD-L2) in B-NHLs remains largely to be characterized.
  • A series of 161 lymphoma tissue and 11 blood samples was analyzed using either immunohistochemistry or flow cytometry.
  • In reactive lymph nodes, PD-1 was mainly expressed in follicular T cells.
  • In B-NHLs, PD-1 was mainly expressed in reactive T cells; but expression was also noted in neoplastic B cells from small lymphocytic lymphoma (SLL, 12/13), grade III follicular lymphoma (3/3), and diffuse large cell lymphoma (2/25).
  • In contrast, neoplastic B cells from mantle cell lymphoma (0/11), marginal zone lymphoma (0/12), Burkitt lymphoma (0/3), and grade 1 to 2 follicular lymphoma (0/40) were PD-1 negative.
  • PD-L1 and PD-L2 were negative in small B-cell lymphomas, including B-SLL.
  • Flow cytometry showed that blood cells from chronic lymphocytic leukemia (B-CLL) also displayed PD-1 expression, which could be increased by CD40 stimulation.
  • These results show that PD-1 expression among B-NHLs is mainly associated with SLL/CLL and is influenced by activation of the CD40/CD40L pathway.
  • Because the anti-PD-1.6.4 antibody works on paraffin sections, it represents a useful tool to differentiate SLL/CLL from other small B-cell lymphomas.
  • [MeSH-major] Antigens, CD / metabolism. Apoptosis Regulatory Proteins / metabolism. Biomarkers, Tumor / metabolism. Immunoblastic Lymphadenopathy / metabolism. Leukemia, Lymphocytic, Chronic, B-Cell / metabolism. Lymphoma, T-Cell / metabolism
  • [MeSH-minor] Animals. Diagnosis, Differential. Flow Cytometry. Lymph Nodes / metabolism. Lymph Nodes / pathology. Mice. Mice, Inbred BALB C. Programmed Cell Death 1 Receptor

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  • [ErratumIn] Hum Pathol. 2010 Nov;41(11):1655. Seriari, Nacer [corrected to Serriari, Nacer]
  • (PMID = 18479731.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Apoptosis Regulatory Proteins; 0 / Biomarkers, Tumor; 0 / PDCD1 protein, human; 0 / Programmed Cell Death 1 Receptor
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47. Guven M, Bulut Y, Aladag I, Yelken K, Erdoğan H: Serum leptin levels in patients with nasal polyposis. J Laryngol Otol; 2008 Jun;122(6):590-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in patients with nasal polyposis.
  • OBJECTIVES: The aim of this study was to investigate the serum leptin levels in patients with nasal polyposis.
  • RESULTS: Serum leptin levels were 12.10 +/- 9.39 ng/ml in the nasal polyposis patients and 6.17 +/- 7.68 ng/ml in the controls.
  • A significant difference (p = 0.021) was observed in the mean serum leptin levels between nasal polyposis patients and controls.
  • CONCLUSION: Serum leptin levels were found to be significantly higher in patients with nasal polyposis.
  • Leptin, apart from its primary role in the regulation of body weight and energy expenditure, may have a role in the inflammatory response of nasal polyposis.
  • [MeSH-major] Leptin / blood. Nasal Polyps / blood

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  • (PMID = 17625035.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin
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48. Dingiloglu BS, Gungor T, Ozdal B, Cavkaytar S, Bilge U, Mollamahmutoglu L: Serum leptin levels in women with uterine leiomyomas. Taiwan J Obstet Gynecol; 2007 Mar;46(1):33-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in women with uterine leiomyomas.
  • OBJECTIVE: The purpose of this study was to examine the influence of leptin in women with uterine myoma.
  • In all subjects, FSH, LH, E2, prolactin, hemoglobin, hematocrit, blood urea nitrogen, creatinine, fasting glucose, CA125, and leptin were examined, and body mass index (BMI) was calculated.
  • RESULTS: Although leptin level was higher in the myomatic women (5.73 +/- 4.08 ng/mL) than in the normal women, there was no statistically significant difference (p = 0.303).
  • Also, no statistical difference in the ratios of leptin/BMI was found in both groups.
  • A significant correlation was found between high E2 level and myoma uteri (p = 0.021).
  • Hemoglobin levels were significantly lower in the myomatic women (p = 0.044).
  • When we compared the leptin levels according to BMI, leptin levels were higher in patients who had BMI > 30 (p = 0.02).
  • CONCLUSION: We did not find any significant difference in serum leptin levels between the two groups.
  • But leptin may have an indirect role in the pathogenesis of uterine leiomyoma.
  • So further research is needed to reveal the role of leptin in myoma uteri pathogenesis.
  • [MeSH-major] Leiomyoma / blood. Leptin / blood. Uterine Neoplasms / blood

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  • (PMID = 17389186.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / Hemoglobins; 0 / Hormones; 0 / Leptin
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49. Calka O, Metin A, Dülger H, Erkoç R: Effect of cyproheptadine on serum leptin levels. Adv Ther; 2005 Sep-Oct;22(5):424-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of cyproheptadine on serum leptin levels.
  • Leptin is a 167 amino acid protein encoded by the obesity gene that is synthesized in adipose tissue and interacts with receptors in the hypothalamus linked to the regulation of appetite and metabolism.
  • Although both leptin and cyproheptadine are effective in controlling appetite, their interaction has not been addressed in clinical studies.
  • This study evaluated serum leptin concentrations in patients who received cyproheptadine to treat a variety of disorders.
  • Serum leptin levels were determined by leptin radioimmunoassay.
  • The mean body weight at baseline (52.59 kg) did not differ significantly from that at 1 week after treatment (52.84 kg; P > .05), but the mean leptin level after 1 week of treatment with cyproheptadine (3.14 ng/mL) was 14.2% higher than that at baseline (2.75 ng/mL; P < .05).
  • This increase may suggest that both leptin and cyproheptadine may affect appetite via similar receptors and that cyproheptadine does not impair leptin activity through these receptors.
  • [MeSH-major] Appetite Stimulants / pharmacology. Cyproheptadine / pharmacology. Leptin / blood

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  • (PMID = 16418149.001).
  • [ISSN] 0741-238X
  • [Journal-full-title] Advances in therapy
  • [ISO-abbreviation] Adv Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Appetite Stimulants; 0 / Leptin; 2YHB6175DO / Cyproheptadine
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50. Ozkan S, Erel CT, Madazli R, Aydinli K: Serum leptin levels in hypertensive disorder of pregnancy. Eur J Obstet Gynecol Reprod Biol; 2005 Jun 1;120(2):158-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in hypertensive disorder of pregnancy.
  • OBJECTIVE: To determine serum leptin levels in hypertensive disorder of pregnancy.
  • MATERIALS AND METHODS: In this prospective, cross-sectional, case control study, we measured serum leptin levels of 58 hypertensive pregnant women and 54 normal pregnant women.
  • We also did blood and urine analysis for the evaluation of the severity of hypertensive disorder of pregnancy.
  • We analysed the difference and correlation between anthropometric measures, hormonal and biochemical parameters, and serum leptin levels in two groups.
  • RESULTS: In the study group, serum leptin levels were determined to be higher than the control group.
  • While the serum uric acid, urea, aspartate aminotransferase, fibronectin, and fasting blood glucose levels were found to be higher, serum total protein and albumin levels were significantly lower among the hypertensive pregnant women.
  • Serum leptin levels were highly and positively correlated with serum fibronectin, and C peptide levels.
  • A negative significant correlation was observed between maternal serum leptin levels and neonatal birth weight among the pregnant women having the hypertensive disorders.
  • CONCLUSION: Serum leptin levels in hypertensive pregnant women appear to be higher.
  • The determination of serum leptin levels may be as important as serum fibronectin and C peptide levels in the management of hypertensive disorder of pregnancy.
  • C peptide and insulin may be due to hyperinsulinemia which leads to increased stimulation of leptin production by fatty tissue.
  • [MeSH-major] Hypertension, Pregnancy-Induced / blood. Leptin / blood

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  • (PMID = 15925044.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / C-Peptide; 0 / Fibronectins; 0 / Leptin
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51. Demir B, Guven S, Guven ES, Atamer Y, Gunalp GS, Gul T: Serum leptin level in women with unexplained infertility. J Reprod Immunol; 2007 Oct;75(2):145-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin level in women with unexplained infertility.
  • INTRODUCTION: The aim of this study was to compare serum levels of leptin in women with unexplained infertility with fertile subjects.
  • MATERIAL AND METHOD: Serum leptin levels of 27 infertile and 30 fertile women on day 3 of the menstrual cycle were assessed and compared in this prospective age and body mass index (BMI) comparable controlled study.
  • The mean serum leptin level was significantly higher in women with unexplained infertility compared with fertile subjects.
  • Considering normal weight subjects, mean serum leptin levels were increased significantly in the unexplained infertile group compared with the fertile group (7.2 (range, 4.3-10.4) versus 3.5 (range, 1.9-6.2)ng/ml, respectively; p<0.0001, Mann-Whitney U-test).
  • The significant increase in serum leptin levels was observed also in overweight patients (6.8 (range, 1.3-5.2) versus 3.3 (range, 4.2-8.9)ng/ml, respectively; p<0.0001, Mann-Whitney U-test).
  • CONCLUSION: A significant difference in serum leptin levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.
  • [MeSH-major] Infertility, Female / etiology. Leptin / blood

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  • (PMID = 17485120.001).
  • [ISSN] 0165-0378
  • [Journal-full-title] Journal of reproductive immunology
  • [ISO-abbreviation] J. Reprod. Immunol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Leptin
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52. Donovan A, Schweitzer ME, Garcia RA, Nomikos G: Chronic lymphocytic leukemia/small lymphocytic lymphoma presenting as septic arthritis of the shoulder. Skeletal Radiol; 2008 Nov;37(11):1035-9
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  • [Title] Chronic lymphocytic leukemia/small lymphocytic lymphoma presenting as septic arthritis of the shoulder.
  • Biopsy performed to assess for possible osteomyelitis demonstrated chronic lymphocytic leukemia/small lymphocytic lymphoma.
  • Intra-articular lymphoma is a rare but important consideration in patients with atypical clinical presentation.
  • Imaging alone may be insufficient to render diagnosis as lymphoma can mimic infection, synovial hypertrophic processes, and depositional arthropathy.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Shoulder Pain / diagnosis
  • [MeSH-minor] Arthritis, Infectious / diagnosis. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18521594.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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53. Jose VJ, Mariappan P, George PV, Selvakumar, Selvakumar D: Serum leptin levels in acute myocardial infarction. Indian Heart J; 2005 Jan-Feb;57(1):39-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in acute myocardial infarction.
  • BACKGROUND: Several studies have shown an association of serum leptin levels with cardiovascular diseases.
  • The present study was undertaken to assess levels of serum leptin in patients presenting with acute ST segment elevation myocardial infarction.
  • The serum leptin levels in patients with myocardial infarction was 6.51 +/- 6.76 ng/ml versus 2.86 +/- 2.22 ng/ml in controls.
  • In the multivariate analysis the odds ratio for serum leptin with myocardial infarction was 1.45 with a 95% confidence interval of 1.2 to 1.8.
  • CONCLUSIONS: Our results suggest that serum leptin level is elevated in patients with acute ST segment elevation myocardial infarction.
  • [MeSH-major] Leptin / blood. Myocardial Infarction / blood

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  • (PMID = 15852893.001).
  • [ISSN] 0019-4832
  • [Journal-full-title] Indian heart journal
  • [ISO-abbreviation] Indian Heart J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Leptin
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54. Shafi R, Afzal MN: Status of serum leptin levels in females with infertility. Saudi Med J; 2008 Oct;29(10):1419-22
MedlinePlus Health Information. consumer health - Female Infertility.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Status of serum leptin levels in females with infertility.
  • OBJECTIVE: To assess serum leptin levels in infertile females referred to a tertiary care hospital in Pakistan.
  • Serum leptin levels of 44 infertile females were compared with 44 age matched fertile female controls.
  • RESULTS: The results revealed that serum leptin levels were significantly raised in infertile women (69.7+/-40.2ng/ml) as compared to fertile controls (41.1+/-27.3ng/ml) with p=0.000.
  • Moreover, a strong positive correlation was found between BMI and leptin levels as leptin levels increased with increase in BMI.
  • Mean leptin levels in overweight women were significantly higher (81.4+/-32.4ng/ml) as compared to normal weight women (30.6+/-20.6ng/ml) with p=0.000.
  • However, further studies are required to determine the exact mechanism by which enhanced body mass and serum leptin levels lead to female infertility.
  • [MeSH-major] Infertility, Female / blood. Leptin / blood

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  • (PMID = 18946565.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin
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55. Wang PJ, Liu LW, Luo H, Xiao H, Cao H, Yu Y: [Serum leptin level in patients with obstructive sleep apnea-hypopnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Apr;40(4):243-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Serum leptin level in patients with obstructive sleep apnea-hypopnea syndrome].
  • OBJECTIVE: To investigate the effect of uvulopalatopharyngoplasty on changes of serum leptin levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).
  • Pretreatment and post-uppp serum leptin concentrations in patients with OSAHS and in BMI-matched controls were measured by radioimmunoassay.
  • Correlations between leptin concentrations and AHI, BMI were analyzed.
  • RESULTS: The concentrations of leptin in patients with OSAHS were higher than that in controls (P < 0.05).
  • Mean levels (x+/-s) of leptin were (9.8+/-2.1) microg/L, (14.2+/-6.7) microg/L, and (19.3+/-7.9) microg/L in patients with severe, mediate and mild obstructive sleep apnea, respectively.
  • Serum leptin levels correlated positively with the degree of OSAHS as reflected by AHI (r = 0.
  • The leptin concentration of 51 responders after 6 months were significantly decreased (P < 0.01) than that of pre-operation.
  • However, the difference of leptin concentration between pre-operation and post operation was not significant in 9 nonresponders (P > 0.05).
  • CONCLUSIONS: There are higher leptin concentrations in patients with OSAHS, which are significantly correlated to the severity of disease.
  • Serum leptin levels in responders decreased significantly after uvulopalatopharyngoplasty.
  • OSAHS may influence the leptin system, resulting in increased serum leptin level.
  • [MeSH-major] Leptin / blood. Sleep Apnea, Obstructive / blood

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  • (PMID = 16008254.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Leptin
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56. Neuteboom RF, Verbraak E, Voerman JS, van Meurs M, Steegers EA, de Groot CJ, Laman JD, Hintzen RQ: Serum leptin levels during pregnancy in multiple sclerosis. Mult Scler; 2009 Aug;15(8):907-12
MedlinePlus Health Information. consumer health - Multiple Sclerosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels during pregnancy in multiple sclerosis.
  • Leptin has been identified as a hormone that can influence inflammatory activity.
  • OBJECTIVE: The aim of this study was to investigate whether pregnancy-induced fluctuations of serum leptin levels differed between patients with MS and controls and whether serum leptin levels correlate with periods of enhanced and diminished disease activity.
  • Serum leptin and soluble leptin receptor (SLR) levels were measured using enzyme-linked immunosorbent assay.
  • RESULTS: Pre-pregnancy serum leptin levels were (mean +/- SD) 22.9 +/- 12.8 ng/ml in the MS group.
  • These levels increased in the third trimester to 28.5 +/- 15.0 ng/ml (P = 0.007).
  • The third trimester serum leptin levels in healthy women were comparable, 29.4 +/- 19.0 ng/ml.
  • Serum leptin levels after delivery dropped to 18.5 +/- 12.8 ng/ml in women with MS (P < 0.001) and to a lesser extend (22.0 +/- 17.5 ng/ml) in healthy women (P = 0.04).
  • SLR levels showed the same pattern.
  • Remarkably, women with the highest relative decrease in serum leptin levels after delivery had more often a postpartum relapse (P = 0.008).
  • CONCLUSION: In women with MS, leptin increased during late pregnancy.
  • A postdelivery drop in leptin levels was observed in both the MS and control group.
  • [MeSH-major] Leptin / blood. Multiple Sclerosis / blood. Pregnancy Complications / blood
  • [MeSH-minor] Adult. Biomarkers / blood. Case-Control Studies. Enzyme-Linked Immunosorbent Assay. Female. Humans. Postpartum Period / blood. Pregnancy. Pregnancy Trimesters / blood. Prospective Studies. Receptors, Leptin / blood. Recurrence. Young Adult

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  • (PMID = 19667019.001).
  • [ISSN] 1352-4585
  • [Journal-full-title] Multiple sclerosis (Houndmills, Basingstoke, England)
  • [ISO-abbreviation] Mult. Scler.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin; 0 / Receptors, Leptin; 0 / leptin receptor, human
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57. Singh I, Joshi M, Agarwal S, Singh UR, Saran R: Extra-nodal small cell lymphocytic lymphoma of prostate: an unusual cause of lower urinary tract symptoms. Urology; 2008 Mar;71(3):547.e7-9
MedlinePlus Health Information. consumer health - Prostate Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-nodal small cell lymphocytic lymphoma of prostate: an unusual cause of lower urinary tract symptoms.
  • Malignant lymphoma of the prostate is a rare occurrence.
  • We describe a case of 60-year-old man presenting with acute urinary retention due to small cell lymphocytic secondary lymphoma of the prostate.
  • We present the clinical manifestation of the disease emphasizing that all lower urinary tract symptom (LUTS) cases should be evaluated for the potential that metastatic cancers or lymphomas may present with such a diagnosis.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / complications. Prostatic Neoplasms / complications. Urethral Obstruction / etiology. Urinary Bladder Neck Obstruction / etiology. Urinary Retention / etiology

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  • (PMID = 18342214.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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58. Gol M, Ozsener S, Sendag F, Uretmen S, Oztekin K, Tanyalcin T, Bilgin O: Does tibolone affect serum leptin levels and body weight in postmenopausal women? Arch Gynecol Obstet; 2005 Jul;272(2):127-30
MedlinePlus Health Information. consumer health - Body Weight.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does tibolone affect serum leptin levels and body weight in postmenopausal women?
  • OBJECTIVES: Leptin has a significant role in body weight regulation and energy balance.
  • We examined the effect of tibolone on the body weight and serum leptin levels in postmenopausal women.
  • Absolute and body mass index (BMI)-corrected serum leptin concentrations and BMI values were measured at baseline, after 3 months, and after 6 months of the tibolone therapy.
  • RESULTS: Tibolone did not affect absolute and BMI-corrected serum leptin levels, and BMI values during the treatment.
  • A significant linear correlation between BMI values and serum leptin levels was observed (p<0.05, r=0.67).
  • CONCLUSIONS: Tibolone seems not to affect serum leptin levels, body weight and BMI values of postmenopausal women.
  • There is a significant correlation between serum leptin levels and BMI values.
  • [MeSH-major] Body Weight / drug effects. Estrogen Receptor Modulators / pharmacology. Leptin / blood. Norpregnenes / pharmacology. Postmenopause / drug effects

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  • (PMID = 15517326.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Estrogen Receptor Modulators; 0 / Leptin; 0 / Norpregnenes; FF9X0205V2 / tibolone
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59. Poterucha JT, Westberg M, Nerheim P, Lovell JP: Rituximab-induced polymorphic ventricular tachycardia. Tex Heart Inst J; 2010;37(2):218-20
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  • The anti-CD20 monoclonal antibody rituximab is an effective treatment for small lymphocytic lymphoma; however, it has been associated with infusion reactions, including cardiac arrhythmias.

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  • (PMID = 20401299.001).
  • [ISSN] 1526-6702
  • [Journal-full-title] Texas Heart Institute journal
  • [ISO-abbreviation] Tex Heart Inst J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
  • [Other-IDs] NLM/ PMC2851419
  • [Keywords] NOTNLM ; Antibodies, monoclonal/administration & dosage/adverse effects / cardiac pacing, artificial / electrocardiography / heart rate / long QT syndrome/diagnosis/etiology / lymphoma, B-cell/drug therapy / rituximab / tachycardia, ventricular/chemically induced/mortality / tachycardia/diagnosis / torsades de pointes/diagnosis/etiology
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60. Yan GT, Hao XH, Xue H, Lin J, Zhang K, Wang LH: [Changes in serum leptin levels in patients with surgically induced stress responses]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2006 Mar;18(3):172-5
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  • [Title] [Changes in serum leptin levels in patients with surgically induced stress responses].
  • OBJECTIVE: To explore the effect of operative trauma induced stress responses on serum leptin levels.
  • METHODS: Serum samples of patients who had undergone resection of hepatic tumors or cholecystectomy were collected, and highly sensitive radioimmunoassay and enzyme-linked immunoadsorbent assay (ELISA) were used to determine serum levels of leptin, granulocyte-clone stimulating factor (G-CSF), C-reactive protein (CRP) and adrenocorticotropin hormone (ACTH) in the blood of these patients.
  • RESULTS: Compared with self-control before operation, serum leptin levels decreased slightly right after an abdominal operation (T0), it reached the highest level 1 day after operation (T1), and began to decrease from 2 days (T2) to 4 days after operation (T4), but the level was still higher than that before operation.
  • Serum leptin levels of patients undergoing laparoscopic operation showed no significant difference when compared with that of laparotomy patients.
  • G-SF levels decreased significantly after operation in both groups, and didn't recover to the levels before operation from T1 to T4.
  • CRP levels slightly decreased in both groups at T0, but increased significantly higher than the levels before operation from T1 to T4.
  • ACTH levels of decreased significantly in laparotomy patients from T0 to T1, and began to recover on T2, while that of laparoscopic operation patients showed no significant difference before and after operation.
  • CONCLUSION: Serum leptin levels of patients increase significantly and constantly subsequent to operative trauma induced stress responses, but this change has no correlation with that of CRP, G-SF and ACTH.
  • [MeSH-major] Leptin / blood. Surgical Procedures, Operative

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  • (PMID = 16524513.001).
  • [ISSN] 1003-0603
  • [Journal-full-title] Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
  • [ISO-abbreviation] Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Leptin; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 9002-60-2 / Adrenocorticotropic Hormone; 9007-41-4 / C-Reactive Protein
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61. Kastenbaum HA, Khalbuss WE, Felgar RE, Stoller R, Monaco SE: The spectrum of coincident entities with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) diagnosed by cytology. Cytojournal; 2010;7:20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The spectrum of coincident entities with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) diagnosed by cytology.
  • BACKGROUND: The cytologic diagnosis of Small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) often relies on finding a small lymphoid population with the characteristic immunoprofile by ancillary testing.
  • There are only a few reports of other processes identified with SLL/CLL.
  • The aim of this study was to review the fine needle aspiration (FNA) and touch prep (TP) diagnoses of SLL/CLL in order to identify any coincident entities.
  • MATERIALS AND METHODS: We retrospectively reviewed all FNA and TP cytology cases between January 2005 and May 2009 with a diagnosis of SLL/CLL to determine the presence of any coincident process.
  • Coincident entities were identified in nine cases (31%) and included seven (28%) neoplastic entities (Hodgkin lymphoma [HL], adenocarcinoma, squamous cell carcinoma, seminoma) and two (7%) non-neoplastic entities (infection and immunoglobulin containing cells).
  • Six cases (21%) suspicious for large cell transformation were also identified.
  • CONCLUSION: In our review of SLL/CLL, coincident entities were present in 31% of the cases and included a spectrum of non-neoplastic and neoplastic processes.
  • FC was the most frequently utilized ancillary test, but IHC provided important information by excluding a mantle cell lymphoma or confirming a coincident process.

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  • (PMID = 20976208.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2955352
  • [Keywords] NOTNLM ; Chronic lymphocytic leukemia / SLL/CLL / cytopathology / small lymphocytic lymphoma
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62. Al-Hussaini MA, Al-Masad JK, Awidi AA: Carcinoma of breast co-existing with non-Hodgkin's lymphoma of axillary lymph nodes. Saudi Med J; 2008 Jan;29(1):138-41
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  • [Title] Carcinoma of breast co-existing with non-Hodgkin's lymphoma of axillary lymph nodes.
  • The co-existence of breast carcinoma and lymphoma in the axillary lymph nodes, without a history of previous chemotherapy or radiotherapy is rarely described.
  • Examination of the axillary lymph nodes as axillary clearance showed concomitant small lymphocytic lymphoma and chronic lymphocytic leukemia, with no evidence of metastatic mammary carcinoma deposits.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Breast Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Axilla. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 18176690.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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63. Alberici A, Bocchio L, Geroldi C, Zanardini R, Bonomini C, Bugari G, Iacobello C, Caimi L, Gennarelli M, Zanetti O, Valerio A, Nisoli E, Borroni B, Padovani A: Serum leptin levels are higher in females affected by frontotemporal lobar degeneration than Alzheimer's disease. J Neurol Neurosurg Psychiatry; 2008 Jun;79(6):712-5
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  • [Title] Serum leptin levels are higher in females affected by frontotemporal lobar degeneration than Alzheimer's disease.
  • The adipocyte derived hormone leptin is known to play a foundamental role in food intake and energy balance.
  • To understand whether leptin could be involved in FTLD eating abnormalities, we measured serum leptin levels in 59 patients with FTLD compared with 25 with AD.
  • Serum leptin levels in patients with FTLD were comparable with those in patients with AD.
  • Nevertheless, females with FTLD showed significantly higher leptin levels compared with females with AD.
  • Hyperphagic FTLD females showed higher circulating leptin levels in comparison with those without eating abnormalities; no differences were found between males with FTLD with respect to serum leptin and food intake disturbances.
  • The present study showed a selective gender difference in leptin levels between females with FTLD and AD, which may suggest specific cognitive and behavioural networks need to be investigated.
  • [MeSH-major] Alzheimer Disease / blood. Dementia / blood. Leptin / blood
  • [MeSH-minor] Activities of Daily Living. Aged. Aged, 80 and over. Female. Humans. Hyperphagia / blood. Hyperphagia / diagnosis. Male. Mental Status Schedule. Middle Aged. Neuropsychological Tests. Reference Values. Sex Factors

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  • (PMID = 18245138.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leptin
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64. Gunstad J, Spitznagel MB, Keary TA, Glickman E, Alexander T, Karrer J, Stanek K, Reese L, Juvancic-Heltzel J: Serum leptin levels are associated with cognitive function in older adults. Brain Res; 2008 Sep 16;1230:233-6
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  • [Title] Serum leptin levels are associated with cognitive function in older adults.
  • Recent work suggests that leptin, a circulating adipokinine hormone, might contribute to age-related cognitive decline.
  • The present study investigated the relationship between serum leptin levels and cognitive function in older adults.
  • Partial correlations adjusting for demographic and medical conditions showed that higher leptin levels were associated with poorer performance on Trail Making Test B (r = .46, p = .01).
  • These findings indicate that serum leptin levels are negatively associated with speeded executive function in older adults without significant neurological or psychiatric conditions.
  • [MeSH-major] Aged / physiology. Aged / psychology. Cognition / physiology. Leptin / blood

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  • (PMID = 18675793.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Insulin; 0 / Leptin
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65. Konishi N, Otaka M, Odashima M, Jin M, Wada I, Komatsu K, Sato T, Kato S, Matsuhashi T, Watanabe S: Systemic stress increases serum leptin level. J Gastroenterol Hepatol; 2006 Jul;21(7):1099-102
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  • [Title] Systemic stress increases serum leptin level.
  • BACKGROUND AND AIM: Leptin, the product of the obese (ob) gene, is a circulating peptide mainly synthesized by adipocytes.
  • Leptin inhibits food intake and decreases body weight.
  • A recent report has suggested that the gastric mucosa is also the source of leptin, and that the stomach leptin also contributes to the regulation of the serum leptin level.
  • The aim of the present study was to investigate the effect of water-immersion stress on serum, stomach and adipose tissue leptin levels to understand the relationship between stress and eating behavior.
  • The leptin level in the serum, gastric mucosa and adipose tissue was measured using ELISA system before and after the initiation of water-immersion stress.
  • RESULTS: The serum leptin level was significantly increased by water-immersion stress.
  • However, the gastric leptin level significantly decreased 6 and 9 h after the stress.
  • The adipose tissue leptin level significantly increased 3 h after the stress.
  • CONCLUSIONS: The results suggest that changes in serum leptin levels could be associated with stimulation of leptin secretion from the gastric mucosa and leptin production in the adipose tissue by systemic stress and that leptin might be regulated by stress-related events.
  • [MeSH-major] Leptin / blood. Stress, Physiological / metabolism

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  • (PMID = 16824059.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin
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66. Cerman AA, Bozkurt S, Sav A, Tulunay A, Elbaşi MO, Ergun T: Serum leptin levels, skin leptin and leptin receptor expression in psoriasis. Br J Dermatol; 2008 Sep;159(4):820-6
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  • [Title] Serum leptin levels, skin leptin and leptin receptor expression in psoriasis.
  • Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure.
  • OBJECTIVES: To investigate the possible role of leptin in psoriasis pathogenesis.
  • Serum fasting leptin levels of the study group were examined by enzyme-linked immunosorbent assay.
  • Tissue leptin and leptin receptor expression of both patients and controls were investigated by immunohistochemistry.
  • RESULTS: Serum leptin levels, tissue leptin and leptin receptor expression were significantly higher in patients with severe psoriasis than patients with mild-moderate psoriasis and controls (P < 0.05).
  • Serum leptin levels showed a positive correlation with Psoriasis Area and Severity Index and involved body surface area in patients with psoriasis.
  • In addition, serum leptin levels, tissue leptin and leptin receptor expression showed a positive correlation with disease duration in patients with psoriasis (P < 0.01, r = 0.979; P < 0.01, r = 0.691; P < 0.01, r = 0.428, respectively).
  • CONCLUSIONS: We assume that leptin might serve as a marker of severity in psoriasis and also may be a pathogenetic cofactor contributing to chronicity of the disease.
  • In addition, drugs targeting the proinflammatory effects of leptin may be a new adjuvant therapeutic approach in psoriasis.
  • [MeSH-major] Leptin / metabolism. Psoriasis / metabolism. Receptors, Leptin / metabolism

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  • (PMID = 18637894.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin; 0 / Receptors, Leptin
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67. Gecici O, Kuloglu M, Atmaca M, Tezcan AE, Tunckol H, Emül HM, Ustundag B: High serum leptin levels in depressive disorders with atypical features. Psychiatry Clin Neurosci; 2005 Dec;59(6):736-8
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  • [Title] High serum leptin levels in depressive disorders with atypical features.
  • Leptin is thought to be related to vegetative symptoms of depression such as alterations in food intake and weight.
  • We have found that the serum leptin levels were higher in patients with atypical depressive disorder than in controls, but not in patients with non-atypical depressive disorder, however, body mass index, age, and gender were not significantly different between these groups.
  • [MeSH-major] Depressive Disorder / blood. Depressive Disorder / psychology. Leptin / blood

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  • (PMID = 16401252.001).
  • [ISSN] 1323-1316
  • [Journal-full-title] Psychiatry and clinical neurosciences
  • [ISO-abbreviation] Psychiatry Clin. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Insulin; 0 / Leptin; 12629-01-5 / Human Growth Hormone; WI4X0X7BPJ / Hydrocortisone
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68. Kayardi M, Icagasioglu S, Yilmaz A, Candan F: Serum leptin levels and malnutrition in patients with chronic renal failure. Saudi Med J; 2006 Apr;27(4):477-81
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  • [Title] Serum leptin levels and malnutrition in patients with chronic renal failure.
  • OBJECTIVE: To investigate the correlation between serum leptin levels, body mass index, and triceps skin fold thickness, which are anthropometric measurements, as well as serum albumin levels in patients with chronic renal failure on hemodialysis.
  • Similarly, patients with diabetes mellitus, chronic pulmonary disorders, and hepatic cirrhosis or hepatitis B, hepatitis C carriers as well as those on active tuberculosis therapy were excluded.
  • The mean serum leptin level for males was 4.61 +/- 4.20 ngr/dl (0.1-18.7 ngr/dl), and for females, it was 52.06 +/- 61.67 ngr/dl (0.6-172.5 ngr/dl).
  • A positive correlation was observed between triceps skin fold thickness and leptin, both in the male group (r=0.478; p<0.05), and in the female group (r=0.876; p<0.05).
  • Body mass index and leptin were also correlated positively both in the male group (r=0.502; p<0.05) and in the female group (r=0.905; p<0.05).
  • No correlation was established between serum albumin levels and leptin.
  • Leptin did not correlate with other measured parameters CONCLUSION: Our study demonstrates that serum leptin levels positively correlated with body mass index and triceps skin fold thickness, which are malnutrition parameters.
  • Therefore, the leptin hormone may be utilized in obtaining preliminary information regarding malnutrition.
  • [MeSH-major] Kidney Failure, Chronic / blood. Kidney Failure, Chronic / complications. Leptin / blood. Malnutrition / blood. Malnutrition / complications

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  • (PMID = 16598323.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Leptin
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69. Yalçindağ FN, Kisa U, Batioğlu F, Yalçindağ A, Ozdemir O, Cağlayan O: Serum leptin levels in patients with ocular and nonocular Behçet's disease. Mediators Inflamm; 2007;2007:31986
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  • [Title] Serum leptin levels in patients with ocular and nonocular Behçet's disease.
  • AIMS: To investigate serum leptin levels in Behçet's patients with or without ocular involvement compared with healthy subjects and the relationship between serum leptin and uveitis activity in patients with ocular involvement.
  • C-reactive protein, alpha 1-antitrypsin, and serum leptin levels were measured in all samples.
  • RESULTS: There was a significant difference between the patients with Behçet's disease and control group for both logarithm of leptin (P = .000) and logarithm of CRP (P = .031).
  • Logarithm of leptin in non-ocular Behçet's patients was significantly higher compared to its level in ocular Behçet's disease and controls (P = .009).
  • CONCLUSIONS: Leptin might have a possible role in the pathogenesis of Behçet's disease.
  • [MeSH-major] Behcet Syndrome / blood. Leptin / blood

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  • (PMID = 17641728.001).
  • [ISSN] 1466-1861
  • [Journal-full-title] Mediators of inflammation
  • [ISO-abbreviation] Mediators Inflamm.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin; 0 / alpha 1-Antitrypsin; 9007-41-4 / C-Reactive Protein
  • [Other-IDs] NLM/ PMC1906708
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70. Uludag IF, Kulu U, Sener U, Kose S, Zorlu Y: The effect of carbamazepine treatment on serum leptin levels. Epilepsy Res; 2009 Sep;86(1):48-53
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  • [Title] The effect of carbamazepine treatment on serum leptin levels.
  • Leptin is a hormone that plays a major role in the regulation of feeding and energy expenditure.
  • Leptin has been expected to form a link to weight gain in epilepsy with the use of some antiepileptic drugs.
  • The aim of this study is to evaluate the effect of carbamazepine on body weight and serum leptin levels.
  • Serum leptin and insulin levels were measured.
  • Body mass index, leptin and insulin were not significantly elevated in carbamazepine group compared to control subjects (p>0.05).
  • Our study demonstrated that carbamazepine therapy does not affect significantly body mass index, leptin and insulin.
  • Data regarding the effect of carbamazepine on serum leptin level is limited but the results of these recent studies are correlated with ours.
  • [MeSH-major] Anticonvulsants / therapeutic use. Carbamazepine / therapeutic use. Epilepsy / blood. Epilepsy / drug therapy. Leptin / blood

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  • (PMID = 19473818.001).
  • [ISSN] 1872-6844
  • [Journal-full-title] Epilepsy research
  • [ISO-abbreviation] Epilepsy Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Insulin; 0 / Leptin; 33CM23913M / Carbamazepine
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71. Gunaydin R, Kaya T, Atay A, Olmez N, Hur A, Koseoglu M: Serum leptin levels in rheumatoid arthritis and relationship with disease activity. South Med J; 2006 Oct;99(10):1078-83
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  • [Title] Serum leptin levels in rheumatoid arthritis and relationship with disease activity.
  • OBJECTIVES: This study was performed to evaluate serum leptin levels in rheumatoid arthritis (RA) patients and investigate the correlation with serum tumor necrosis factor alpha (TNF-alpha) levels and clinical and laboratory parameters of disease activity.
  • Immunoradiometric assay was used for measuring serum leptin levels (ng/mL).
  • Serum TNF-alpha levels (pg/mL) were measured by sandwich enzyme-linked immunosorbent assay method in 41 of 50 RA patients and in 24 control subjects.
  • Serum leptin levels were higher in RA (P = 0.000).
  • In RA patients, there were no correlations between serum leptin levels and disease duration, swollen and tender joint counts, DAS28, CRP, ESR, serum TNF-alpha levels, oral glucocorticoid and methotrexate usage (P > 0.05).
  • There was no statistically significant serum leptin level difference between patients with high disease activity and mild and low disease activity (P = 0.892).
  • Serum leptin levels positively correlated with BMI in both patient and control groups (P < 0.05).
  • In both groups, mean serum leptin levels were higher in women than men.
  • CONCLUSIONS: Even though serum leptin levels were found to be significantly higher in RA patients than in control subjects in this study, there was no correlation between serum leptin levels and TNF-alpha levels, clinical and laboratory parameters of disease activity.
  • However serum leptin levels positively correlated with BMI in both patient and control groups.
  • In RA, circulating leptin levels do not seem to reflect disease activity.
  • [MeSH-major] Arthritis, Rheumatoid / blood. Leptin / blood


72. Yilmaz M, Kis C, Ceylan NO, Okan V, Pehlivan M, Kuçukosmanoglu E, Yilmaz F, Tarakcioglu M: Serum leptin level in acute myeloid leukemia patients. Hematology; 2008 Feb;13(1):21-3
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  • [Title] Serum leptin level in acute myeloid leukemia patients.
  • Leptin is a regulator of fat metabolism that is synthesized in adipocytes and released into circulation.
  • The serum levels of leptin are, therefore, correlated with body fat mass and show a wide variation in healthy individuals.
  • Leptin may have an additional indirect effect on leukemic hematopoesis.
  • We investigated serum leptin levels with enzyme-linked immunosorbent assays in 14 acute myeloblastic leukemia (AML) patients before and after chemotherapy and compared the results with that of the levels determined 14 healthy controls.
  • We found no significant difference between leptin levels before and after chemotherapy and control group.
  • Therefore, serum leptin level should not be used as a diagnostic marker in acute leukemia patients.
  • However, the possibility of regional leptin production by leukemia blasts in bone marrow stroma creates a high local concentration of leptin within bone marrow microenvironment and systemic leptin level in combination with local leptin production may affect leukemic hematopoesis.
  • [MeSH-major] Leptin / blood. Leukemia, Myeloid, Acute / blood

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  • (PMID = 18534061.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Leptin
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73. Ciprandi G, Filaci G, Negrini S, De Amici M, Fenoglio D, Marseglia G: Serum leptin levels in patients with pollen-induced allergic rhinitis. Int Arch Allergy Immunol; 2009;148(3):211-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in patients with pollen-induced allergic rhinitis.
  • The aim of the study was to evaluate the serum leptin levels in a cohort of patients with pollen-induced allergic rhinitis, enrolled outside the pollen season, and in a group of healthy controls.
  • A skin prick test and blood sampling for assessing serum leptin levels, eosinophils, specific IgE, and nasal challenge were performed in all subjects.
  • RESULTS: After analyzing genders separately, female allergic patients showed significantly higher levels than normal females (p = 0.031), whereas the comparison between allergic and normal males was not significant (p = 0.9651).
  • Leptin serum levels were significantly related with age in normal (p = 0.0059) and allergic (p = 0.0042) females.
  • In addition, BMI and leptin levels were significantly correlated (p = 0.01) in all allergic patients; there were other significant relationships between leptin levels and symptom severity in females (p = 0063, r = 0.68), peripheral eosinophils in males (p = 0.023, r = 0.49), and allergen threshold dose at nasal challenge in both genders (males: p = 0.0001, r = -0.85; females: p = 0.0001, r = -0.95).
  • CONCLUSIONS: This preliminary study provides the first evidence of significantly higher leptin serum levels in female patients with pollen-induced allergic rhinitis outside the pollen season.
  • [MeSH-major] Leptin / blood. Rhinitis, Allergic, Seasonal / blood
  • [MeSH-minor] Adolescent. Adult. Age Factors. Allergens / immunology. Body Mass Index. Bronchial Provocation Tests. Cell Count. Eosinophils / cytology. Female. Humans. Immunoglobulin E / blood. Immunoglobulin E / immunology. Male. Middle Aged. Sex Factors. Skin Tests. Young Adult

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18849612.001).
  • [ISSN] 1423-0097
  • [Journal-full-title] International archives of allergy and immunology
  • [ISO-abbreviation] Int. Arch. Allergy Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Allergens; 0 / Leptin; 37341-29-0 / Immunoglobulin E
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74. Alexander C, Cochran CJ, Gallicchio L, Miller SR, Flaws JA, Zacur H: Serum leptin levels, hormone levels, and hot flashes in midlife women. Fertil Steril; 2010 Aug;94(3):1037-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels, hormone levels, and hot flashes in midlife women.
  • OBJECTIVE: To examine the associations between serum leptin levels, sex steroid hormone levels, and hot flashes in normal weight and obese midlife women.
  • MAIN OUTCOME MEASURE(S): Serum leptin and sex steroid hormone levels.
  • RESULT(S): Correlation and regression models were performed to examine associations between leptin levels, hormone levels, and hot flashes.
  • Leptin levels were associated with BMI, with "ever experiencing hot flashes" (questionnaire), with hot flashes within the last 30 days, and with duration of hot flashes (>1 year, P=.03).
  • Leptin was positively correlated with testosterone, free testosterone index, and free estrogen index and inversely associated with levels of sex hormone-binding globulin.
  • In women with a body mass index>or=30 kg/m2, leptin levels no longer correlated with testosterone levels.
  • CONCLUSION(S): Serum leptin levels are associated with the occurrence and duration of hot flashes in midlife women; however, no correlation was found between leptin and serum estradiol.

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  • [Copyright] Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 19476935.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / R01 AG018400-02; United States / NIA NIH HHS / AG / AG18400; United States / NIA NIH HHS / AG / R01 AG018400-03; United States / NIA NIH HHS / AG / R01 AG018400-05A2; United States / NIA NIH HHS / AG / R01 AG018400-01A1; United States / NIA NIH HHS / AG / R01 AG018400-06; United States / NIA NIH HHS / AG / R01 AG018400; United States / NIA NIH HHS / AG / R01 AG018400-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 0 / Leptin
  • [Other-IDs] NLM/ NIHMS109122; NLM/ PMC3939020
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75. Kose M, Ozdemir MA, Gumus H, Karakukcu M, Akcakus M: Serum leptin levels in patients with childhood immune thrombocytopenic purpura. J Pediatr Hematol Oncol; 2007 Jan;29(1):23-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in patients with childhood immune thrombocytopenic purpura.
  • Leptin is a 16-kd protein secreted from the adipose tissue.
  • Leptin is structurally similar to interleukin (IL)-2, IL-6, and IL-15.
  • The structural similarities between leptin receptor and hematopoietic cytokine receptors suggested that leptin could play a role in hematopoiesis and immune function.
  • Recent studies suggested that leptin could play an important role in autoimmunity.
  • Serum leptin levels were obtained after diagnosis and before treatment and all patients were followed up at least 6 months to designate acute or chronic event.
  • We conclude that in childhood acute ITP, leptin did not play a role in the pathophysiology of the disease.
  • [MeSH-major] Leptin / blood. Purpura, Thrombocytopenic, Idiopathic / blood
  • [MeSH-minor] Acute Disease. Autoimmunity. Child. Child, Preschool. Chronic Disease. Cytokines / blood. Cytokines / chemistry. Cytokines / immunology. Female. Follow-Up Studies. Humans. Infant. Male. Prospective Studies. Structural Homology, Protein. T-Lymphocytes, Helper-Inducer / immunology. T-Lymphocytes, Helper-Inducer / metabolism

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  • (PMID = 17230063.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Leptin
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76. Kim KO, Park SH, Park CH, Han TH, Yoo KS, Kim JH, Lee MS, Kim DJ, Park CK, Cho HD: [Relationship between the severity of liver damage and the serum leptin level for nonalcoholic fatty liver disease]. Korean J Hepatol; 2005 Mar;11(1):51-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Relationship between the severity of liver damage and the serum leptin level for nonalcoholic fatty liver disease].
  • The datas from several studies have suggested that leptin could be involved in the progression from hepatic steatosis to steatohepatitis including the fibrosis.
  • We evaluated serum leptin levels in patients with NAFLD to determine whether any relationships existed between the leptin levels and the severity of hepatic inflammation or fibrosis.
  • We measured the serum leptin level in all cases and liver biopsy samples were obtained from 31 cases.
  • Spearman rank correlations were used to detect the associations between the serum leptin and the various anthropometric and biochemical variables.
  • The relationship between the histologic severity and the serum leptin level was evaluated with logistic regression analysis.
  • RESULTS: Serum leptin levels correlated with insulin, c-peptide, ALT and homeostasis model assessment insulin resistance, but not with BMI, age and gender.
  • Serum leptin level also correlated with hepatic fibrosis, but not with hepatic steatosis or inflammation.
  • However, the serum leptin level was not a significant independent predictor of the grade of hepatic steatosis, inflammation and fibrosis on the univariate analysis.
  • CONCLUSIONS: The serum leptin level was not an independent predictor of the severity of liver damage in NAFLD.
  • [MeSH-major] Fatty Liver / pathology. Leptin / blood. Liver / pathology

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  • (PMID = 15788885.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Leptin
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77. Prabha C, Karthic S, Das SD, Swaminathan S, Subramaniam S, Sukumar B: Impact of tuberculosis on serum leptin levels in patients with HIV infection. Horm Res; 2005;63(5):228-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of tuberculosis on serum leptin levels in patients with HIV infection.
  • As leptin is involved in the weight regulation and cellular immunity, we investigated the role of leptin levels in the co-infection of HIV and TB (HIV-TB).
  • Serum leptin levels and the concentrations of IFN-gamma, TNF-alpha, IL-12 and IL-4 cytokines were measured by ELISA before the start of the treatment.
  • CD4+ T-cell counts were determined in patients with HIV and HIV-TB by flow cytometry.
  • RESULTS: Serum leptin levels and BMI were significantly lower in the patients with HIV-TB than control and HIV subjects.
  • Multivariate regression analysis showed that serum leptin concentration was significantly dependent on BMI and sex but not on age and the disease groups.
  • The leptin levels did not correlate either with CD4+ T-cell counts or with any of the serum cytokines in HIV and HIV-TB patients.
  • CONCLUSION: Thus our finding suggests that the leptin concentrations were strongly associated with BMI and gender but not with the disease state or with the circulating cytokine levels.
  • [MeSH-major] HIV Infections / blood. HIV Infections / microbiology. Leptin / blood. Tuberculosis / blood. Tuberculosis / virology
  • [MeSH-minor] Adult. Body Mass Index. CD4 Lymphocyte Count. Cytokines / blood. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Multivariate Analysis. Regression Analysis

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  • (PMID = 15886489.001).
  • [ISSN] 0301-0163
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cytokines; 0 / Leptin
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78. Oge A, Bayraktar F, Saygili F, Guney E, Demir S: TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients. Endocr J; 2005 Apr;52(2):213-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients.
  • Leptin is considered to play a role in maintenance of energy balance and body weight by neuroendocrine mechanisms.
  • The physiological mechanisms for thyroid hormone-induced alteration in serum leptin are not well known.
  • In the present study, the relationship between thyroid hormones and leptin levels was investigated in patients with overt hypothyroidism and hyperthyroidism before and after successful treatment.
  • Leptin levels were determined by radioimmunoassay and body mass index (BMI) was calculated for each subject.
  • Serum leptin levels of 26 hypothyroid and 22 hyperthyroid patients were compared with those of 20 healthy volunteers who comprised the controls.
  • Serum leptin levels of hypothyroid patients (28.4 +/- 4.1 ng/ml) were found to be significantly higher than the controls (19.1 +/- 3.2 ng/ml) (p<0.01), whereas hyperthyroid patients had lower levels (10.7 +/- 1.2 ng/ml) (p<0.01).
  • In hypothyroid patients, serum leptin levels were decreased significantly to 20.6 +/- 2.1 ng/ml with thyroxin treatment (p<0.05).
  • However, in hyperthyroid group, serum leptin levels were increased to 12.4 +/- 2.2 ng/ml by treatment (p>0.05).
  • The serum leptin levels were correlated with BMI and thyrotropin (TSH) in both hypothyroid and hyperthyroid patients.
  • Serum leptin levels are affected in thyroid disorders and the correlation of leptin with TSH is independent of thyroid hormones.
  • [MeSH-major] Hyperthyroidism / blood. Hypothyroidism / blood. Leptin / blood. Thyroid Hormones / physiology. Thyrotropin / physiology

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  • (PMID = 15863950.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Leptin; 0 / Thyroid Hormones; 06LU7C9H1V / Triiodothyronine; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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79. Semnani S, Roshandel G, Keshtkar A, Najafi L, Amiriani T, Farajollahi M, Moradi A, Joshaghani H: Serum leptin levels and irritable bowel syndrome: a new hypothesis. J Clin Gastroenterol; 2009 Oct;43(9):826-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels and irritable bowel syndrome: a new hypothesis.
  • GOALS: This study was undertaken to investigate the relationship between serum leptin levels and the development irritable bowel syndrome (IBS).
  • Various studies have indicated the relationship between serum leptin levels and stress levels.
  • So searching the relationship between the production and level of this hormone and development of IBS may help to understand the pathophysiology of the disease.
  • Serum leptin level was measured by enzyme-linked immunosorbent assay method.
  • RESULTS: Mean serum leptin levels were 7.41 and 19.33 ng/mL in IBS and control groups, respectively (P<0.001).
  • Participants in IBS group had significantly higher stress levels than controls (P<0.001).
  • Multivariate logistic regression analysis showed that adjusted odds ratios (ORs) for serum leptin level (OR: 0.9; 95% confidence interval: 0.85-0.94) and stress level (OR: 1.15; 95% confidence interval: 1.09-1.23) were nearly the same as crude ones.
  • CONCLUSIONS: This study indicated the relationship between leptin and IBS for the first time.
  • Our results show that serum leptin level is significantly lower in IBS group than controls and this relationship is independent of other variables such as stress levels, body mass index, etc.
  • [MeSH-major] Irritable Bowel Syndrome / blood. Leptin / blood

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  • (PMID = 19398923.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin
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80. Unal M, Unal DO, Baltaci AK, Mogulkoc R, Kayserilioglu A: Investigation of serum leptin levels in professional male football players and healthy sedentary males. Neuro Endocrinol Lett; 2005 Apr;26(2):148-51
MedlinePlus Health Information. consumer health - Exercise for Children.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Investigation of serum leptin levels in professional male football players and healthy sedentary males.
  • OBJECTIVE: In the present study we aimed at investigating leptin levels in professional male athletes who have been exercising regularly for a long time and leptin levels in healthy sedentary males.
  • The relations between groups in terms of leptin levels, Max VO2 levels, blood lactic acid levels before and after exercise and effort durations were investigated.
  • RESULTS: It was found in the study that although BMI of professional male athletes was higher than that of the healthy sedentary males, leptin levels of the former were significantly lower (p<0.01), while VO2Max levels (p<0.05) and test periods (p<0.01) were significantly higher than those in the latter.
  • As for lactic acid levels after exercise and between groups, these were also higher in athletes, but the difference was not statistically significant (p>0.05).
  • CONCLUSION: Leptin levels of those who exercised regularly were found lower than the levels in healthy males.
  • Although the increase in serum leptin levels is in direct proportion with BMI in general, the major determinant of serum leptin level is the body fat rate.
  • As regular exercising reduces body fat rate, it also reduces serum leptin levels.
  • [MeSH-major] Adipose Tissue / physiology. Body Composition / physiology. Exercise. Football / physiology. Leptin / blood

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  • (PMID = 15855887.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Leptin
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81. Unal M, Unal DO, Baltaci AK, Mogulkoc R: Investigation of serum leptin levels and VO2max value in trained young male athletes and healthy males. Acta Physiol Hung; 2005;92(2):173-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Investigation of serum leptin levels and VO2max value in trained young male athletes and healthy males.
  • The present study aimed at investigating serum leptin levels of elite young male athletes who have been regularly exercising for a long period of time and males who do not exercise.
  • Serum leptin levels were determined by RIA.
  • VO2max levels were identified during maximal exercise.
  • Lactic acid levels were identified one minute before and one minute after exercise from the fingertip by Pro-lactate kit.
  • As a result of the tests, although BMI values of trained young male athletes and healthy males were close to each other, leptin levels were significantly lower (p<0.01), VO2max values were significantly higher (p<0.01) and test periods were significantly longer (p<0.001) in the former.
  • In conclusion, regular exercise, by reducing body fat percentage, suppresses serum leptin levels.
  • [MeSH-major] Exercise / physiology. Leptin / blood. Oxygen Consumption / physiology

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  • (PMID = 16268055.001).
  • [ISSN] 0231-424X
  • [Journal-full-title] Acta physiologica Hungarica
  • [ISO-abbreviation] Acta Physiol Hung
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Leptin
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82. Makinodan K, Yoshikawa M, Fukuoka A, Tamaki S, Koyama N, Yamauchi M, Tomoda K, Hamada K, Kimura H: Effect of serum leptin levels on hypercapnic ventilatory response in obstructive sleep apnea. Respiration; 2008;75(3):257-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of serum leptin levels on hypercapnic ventilatory response in obstructive sleep apnea.
  • BACKGROUND: Leptin levels have been reported to be higher in patients with obstructive sleep apnea (OSA) than in control subjects with matching age and body mass index (BMI).
  • Although animal studies have shown that leptin augments hypercapnic ventilatory response (HCVR), the effect of leptin on HCVR has not been clarified in OSA.
  • OBJECTIVES: To investigate whether leptin could augment HCVR during wakefulness in patients with OSA.
  • Fasting serum leptin levels were collected, and HCVR during wakefulness assessed by the slope between minute ventilation and end-tidal PCO(2).
  • RESULTS: There was a significant positive relationship between serum leptin levels and HCVR in the group including control subjects and eucapnic patients with OSA (r = 0.42, p < 0.05).
  • Subgroup analyses suggest that serum leptin levels and HCVR were significantly higher in eucapnic patients with OSA than in control subjects.
  • On the other hand, hypercapnic patients had lower HCVR than eucapnic patients (p < 0.05), whereas serum leptin levels were similar between the two OSA subgroups.
  • CONCLUSION: Leptin levels and HCVR are correlated as long as the eucapnic condition is maintained.
  • We speculate that a stimulating effect of leptin on HCVR may be masked by the hypoventilation state.
  • [MeSH-major] Hypercapnia / blood. Leptin / blood. Sleep Apnea, Obstructive / blood

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  • [Copyright] 2007 S. Karger AG, Basel
  • [CommentIn] Respiration. 2008;75(3):251-2 [18367850.001]
  • (PMID = 18073454.001).
  • [ISSN] 1423-0356
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Leptin; 142M471B3J / Carbon Dioxide
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83. Dubey S, Kabra M, Bajpai A, Pandey RM, Hasan M, Gautam RK, Menon PS: Serum leptin levels in obese Indian children relation to clinical and biochemical parameters. Indian Pediatr; 2007 Apr;44(4):257-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in obese Indian children relation to clinical and biochemical parameters.
  • OBJECTIVE: To evaluate serum leptin levels in obese Indian children and its correlation to anthropometric and biochemical parameters.
  • METHODOLOGY: Leptin levels were measured in 36 children (26 boys, age 1.5 to 15 years) and 37 adults (21 men, age 25 to 69 years) with obesity and 29 normal weight controls (15 children and 14 adults).
  • RESULTS: Leptin levels were higher than controls in obese children (19.4 +/- 6.4 ng/mL against 5.4 +/- 1.7 ng/mL, p = 0.0001) and obese adults (18.9 +/- 6.4 ng/mL against 7.8 +/- 5.6 ng/mL, p = 0.0001).
  • Leptin levels were higher than males in obese girls (23.5 +/- 1.7 ng/mL against 18.0 +/-7.6 ng/mL, p = 0.040) and women (21.3 +/- 4.4 ng/mL against 15.8 +/- 7.4 ng/mL).
  • Leptin levels correlated with body mass index, waist circumference and waist to-hip ratio.
  • A positive correlation was observed between serum leptin and cholesterol, triglycerides and LDL-cholesterol.
  • CONCLUSIONS: Leptin levels correlate significantly with anthropometric and laboratory parameters in obese children.
  • There is a need for further studies on the role of leptin in childhood obesity and metabolic syndrome.
  • [MeSH-major] Leptin / blood. Obesity / metabolism

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  • [CommentIn] Indian Pediatr. 2007 Sep;44(9):708-9; author reply 709-10 [17921565.001]
  • (PMID = 17468520.001).
  • [ISSN] 0019-6061
  • [Journal-full-title] Indian pediatrics
  • [ISO-abbreviation] Indian Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Leptin
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84. Erel F, Gulec M, Kartal O, Caliskaner Z, Ozturk S, Yaman H, Kurt Y, Gocgeldic E, Ors F, Karaayvaz M: Serum leptin levels and lipid profiles in patients with allergic rhinitis and mild asthma. Allergol Immunopathol (Madr); 2007 Nov-Dec;35(6):232-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels and lipid profiles in patients with allergic rhinitis and mild asthma.
  • BACKGROUND: Despite improved understanding of the pathophysiology of allergic rhinitis and asthma, the effect of serum leptin level is still controversial.
  • Only a few studies have been performed to investigate the serum leptin levels in allergic rhinitis and asthma, and contradictory results have been observed.
  • OBJECTIVE: We aimed to investigate the association between leptin, lipid profiles and allergic rhinitis and mild asthma, and to determine whether inhaled and/or intranasal steroids affect the leptin levels.
  • PATIENTS AND METHODS: We studied 43 patients with allergic rhinitis (10 of with mild asthma) (mean age 29.81, range 18-45 yr) and 32 volunteers as a control group (mean age 30.53, range 20-45 yr).
  • RESULTS: Serum leptin levels in patients were 8.49 +/- 10.76 microg/ml, and did not differ from volunteers 5.42 +/- 6.63 microg/ml. (p > 0.05).
  • We found a direct link between increased body mass index (BMI) and serum leptin levels (p = 0.008).
  • No association was seen between leptin and triglyceride, HDL-cholesterol, VLDL-cholesterol, eosinophil, total IgE (p > 0.05); except for total cholesterol and LDL-cholesterol (p < 0.05).
  • Although, no correlation between allergic rhinitis and mild asthma and serum level of leptin was shown, these parameters and age correlations were stronger in female than in male (p = 0.39 for male and p = 0.011 for female), and also found direct link between increased BMI and sex and patients group (p = 0.008 for male and p = 0.0001 for female).
  • We also determined that there was no effect of inhaled and/or intranasal steroids statistically on serum leptin levels.
  • CONCLUSION: Our data demonstrate that the serum levels of leptin and lipid profiles on allergic rhinitis and mild asthma were not different than those in controls.
  • [MeSH-major] Asthma / blood. Leptin / blood. Lipids / blood. Rhinitis, Allergic, Perennial / blood

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  • (PMID = 18047813.001).
  • [ISSN] 0301-0546
  • [Journal-full-title] Allergologia et immunopathologia
  • [ISO-abbreviation] Allergol Immunopathol (Madr)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Leptin; 0 / Lipids; 0 / Lipoproteins, LDL; 37341-29-0 / Immunoglobulin E; 51333-22-3 / Budesonide
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85. Lee SW, Park MC, Park YB, Lee SK: Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis. Rheumatol Int; 2007 Apr;27(6):537-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis.
  • We investigated whether serum leptin levels are elevated in patients with active rheumatoid arthritis (RA) and whether these levels correlate with disease activity.
  • Serum leptin levels were determined using a primate antibody radioimmunoassay.
  • RA patients with high disease activity had significantly higher mean serum leptin levels, compared to those with low activity (14.2 +/- 10.9 vs. 7.0 +/- 3.4 ng/ml, P < 0.05).
  • Mean leptin levels adjusted according to BMI were 0.6 +/- 0.5 ng m(2)/ml kg for the high activity group and 0.3 +/- 0.2 ng m(2)/ml kg for the low activity group, respectively, which were also significantly different (P < 0.05).
  • Both serum leptin levels and leptin levels adjusted according to BMI correlated well with the DAS28 (r = 0.363 and 0.368, P < 0.05) and CRP levels (r = 0.433 and 0.472, P < 0.05), respectively.
  • Mean follow-up leptin level was significantly lower than mean initial leptin level (7.8 +/- 3.7 vs. 16.1 +/- 12.7 ng/ml, P < 0.05).
  • In conclusion, serum leptin levels were higher in RA patients with high disease activity, correlated well with disease activity, and decreased significantly when disease was well controlled.
  • [MeSH-major] Arthritis, Rheumatoid / blood. Arthritis, Rheumatoid / physiopathology. Biomarkers / blood. Leptin / blood. Severity of Illness Index

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  • (PMID = 17102946.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leptin
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86. Al Maskari MY, Alnaqdy AA: Correlation between Serum Leptin Levels, Body Mass Index and Obesity in Omanis. Sultan Qaboos Univ Med J; 2006 Dec;6(2):27-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between Serum Leptin Levels, Body Mass Index and Obesity in Omanis.
  • OBJECTIVE: To ascertain the relationship between serum leptin levels and related variables (weight, Body Mass Index (BMI) and fat percentage) in a group of Omani obese and non-obese healthy subjects.
  • METHODS: Leptin levels were assessed in serum samples from 35 obese Omanis and 20 non-obese healthy subjects.
  • RESULTS: There was a significant difference (p< 0.001) in serum leptin between the obese group (34.78 + 13.96 ng/ml) and the control non-obese subjects (10.6 ± 4.2 ng/ml).
  • Leptin levels were higher in females compared to males.
  • There was a significantly positive correlation between leptin levels in obese subjects with weight (p=0.002), body fat percentage (p=0.0001) and BMI (p=0.001).
  • CONCLUSIONS: We concluded that serum leptin levels are higher in the Omani obese group and correlate positively with body fatness and obesity.

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  • (PMID = 21748132.001).
  • [ISSN] 2075-051X
  • [Journal-full-title] Sultan Qaboos University medical journal
  • [ISO-abbreviation] Sultan Qaboos Univ Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3074914
  • [Keywords] NOTNLM ; Body Mass Index / Body weight / Leptin / Obesity / Oman
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87. Kalyan K, Basu D, Soundararaghavan J: Immunohistochemical typing of non-Hodgkin's lymphoma-comparing working formulation and WHO classification. Indian J Pathol Microbiol; 2006 Apr;49(2):203-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical typing of non-Hodgkin's lymphoma-comparing working formulation and WHO classification.
  • The recent WHO classification of non-Hodgkin's lymphoma is based on the morphology and immunohistochemical expression of the lymphoma cells and to a lesser extent, on the molecular and cytogenetic findings.
  • Fifty-three cases of non-Hodgkin's lymphoma were included in the study.
  • Of these, seven cases were primary extra nodal lymphomas.
  • The two most common types encountered were diffuse large cell lymphoma and small lymphocytic lymphoma.
  • 38 cases (72%) showed B cell expression and 12 cases (22.5%) showed T cell expression.
  • B-cell diffuse large cell lymphoma (26%) was found to be the predominant B cell non-Hodgkin's lymphoma.
  • The commonest T-cell lymphoma was T lymphoblastic lymphoma (67%) followed by peripheral T cell angioimmunoblastic lymphoma (25%).
  • Immunohistochemistry is a useful and necessary diagnostic modality and helps subdivide prognostically different types of non-Hodgkin's lymphoma.
  • [MeSH-major] Lymphoma, Non-Hodgkin / classification
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD20 / metabolism. Antigens, CD3 / metabolism. B-Lymphocytes / immunology. B-Lymphocytes / pathology. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. T-Lymphocytes / immunology. T-Lymphocytes / pathology. World Health Organization

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  • (PMID = 16933715.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD3
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88. Gökbel H, Baltaci AK, Uçok K, Okudan N, Mogulkoç R: Changes in serum leptin levels in strenuous exercise and its relation to zinc deficiency in rats. Biol Trace Elem Res; 2005 Sep;106(3):247-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changes in serum leptin levels in strenuous exercise and its relation to zinc deficiency in rats.
  • This study aimed to investigate the possible changes in serum leptin concentration caused by acute exercise and the effects of zinc deficiency on these changes.
  • All rats were decapitated 48 h after the exercise, and blood samples were collected to determine serum leptin and zinc levels.
  • Serum leptin levels in the exercise groups were lower than in the control groups.
  • Leptin levels in the zinc-deficient-control group were lower than in the control-control group.
  • We conclude that serum leptin levels significantly decrease both 48 h after strenuous exercise and in the zinc-deficient rats, and there is a further decrease in leptin levels when rats fed on a zinc-deficient diet performed exercise.
  • [MeSH-major] Leptin / blood. Physical Conditioning, Animal / physiology. Zinc / deficiency

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  • (PMID = 16141472.001).
  • [ISSN] 0163-4984
  • [Journal-full-title] Biological trace element research
  • [ISO-abbreviation] Biol Trace Elem Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin; J41CSQ7QDS / Zinc
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89. Ustundag B, Gungor S, Aygün AD, Turgut M, Yilmaz E: Oxidative status and serum leptin levels in obese prepubertal children. Cell Biochem Funct; 2007 Sep-Oct;25(5):479-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxidative status and serum leptin levels in obese prepubertal children.
  • The aim of this study was to evaluate the oxidative and antioxidant status and any correlation with leptin in obese prepubertal children.
  • Mean plasma leptin concentration was significantly higher in the obese children.
  • Homocysteine and malondialdehyde (MDA) levels were also significantly higher in the obese group.
  • In conclusion, in prepubertal obese children oxidative stress was increased and MDA and homocysteine levels were well correlated with serum leptin level and BMI.
  • [MeSH-major] Leptin / blood. Obesity / blood. Puberty / blood

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  • (PMID = 16874844.001).
  • [ISSN] 0263-6484
  • [Journal-full-title] Cell biochemistry and function
  • [ISO-abbreviation] Cell Biochem. Funct.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leptin
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90. Zent CS, Ding W, Reinalda MS, Schwager SM, Hoyer JD, Bowen DA, Jelinek DF, Tschumper RC, Call TG, Shanafelt TD, Kay NE, Slager SL: Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis. Leuk Lymphoma; 2009 Aug;50(8):1261-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis.
  • Improved medical care could have altered the clinical presentation and survival of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) complicated by autoimmune disease cytopenia (AID cytopenia).
  • When compared with the historical reported data, our study shows a lower rate of autoimmune hemolytic anemia (2.3%), and similar rates of immune thrombocytopenia (2.0%), and pure red blood cell aplasia (0.5%).
  • AID cytopenia occurred at all stages of CLL, responded well to treatment, did not alter overall survival, and contributed to death in only 6 (12%) patients.

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  • (PMID = 19811329.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA097274; United States / NCI NIH HHS / CA / CA97274
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  • [Other-IDs] NLM/ NIHMS548896; NLM/ PMC3917557
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91. Antunes H, Santos C, Carvalho S: Serum leptin levels in overweight children and adolescents. Br J Nutr; 2009 Apr;101(8):1262-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in overweight children and adolescents.
  • Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis.
  • Our aim was to determine the relationship between serum leptin and clinical and biochemical features in overweight children and adolescents.
  • Overweight children and adolescents followed in this Unit with serum leptin ascertained were included.
  • One outlier of serum leptin was excluded to perform correlation and regression.
  • Serum leptin was determined in 357 patients.
  • Serum leptin levels were significantly related to: sex (mean: girls 48.0 ng/ml, boys 34.4 ng/ml; P = 0.003); Tanner stage (mean: I-II 37.0 ng/ml, III-V 45.2 ng/ml; P = 0.035); systolic blood pressure (mean: normal 41.3 ng/ml, high 44.0 ng/ml; P = 0.009); BMI z-score (r 0.136; P = 0.010); C-peptide (r 0.17; P = 0.002); insulin (r 0.34; P < 0.001); homeostasis model assessment of insulin resistance (HOMA-IR) (r 0.25; P < 0.001) and aspartate aminotransferase (r - 0.12; P = 0.023).
  • In the multivariate analysis (with leptin as the dependent variable and sex, Tanner stage, BMI z-score, systolic blood pressure, aspartate aminotransferase, C-peptide, insulin and HOMA-IR as independent variables), sex and BMI were determinant factors.
  • The present study in overweight children and adolescents showed that being female and greater BMI were significantly and independently associated with increased serum leptin.
  • In this large cohort other associations with leptin described in the literature can be discharged.
  • [MeSH-major] Leptin / blood. Overweight / blood

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  • (PMID = 18755049.001).
  • [ISSN] 1475-2662
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leptin
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92. Sahin M, Tanaci N, Yucel M, Kutlu M, Tutuncu NB, Pamuk B, Guvener ND: Acute effects of orlistat on postprandial serum leptin levels in nondiabetic obese patients. Minerva Endocrinol; 2008 Sep;33(3):169-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute effects of orlistat on postprandial serum leptin levels in nondiabetic obese patients.
  • AIM: Leptin is likely to be involved in the homeostasis of body weight.
  • This study aimed to examine the acute effects of orlistat on postprandial serum glucose, insulin, and leptin levels before any effect on body weight occurred.
  • RESULTS: There were no differences in sex distribution, mean age, anthropometric measurements, and basal glucose, insulin, and leptin levels between the orlistat and placebo groups.
  • Hourly serum glucose and insulin changes were similar between groups, peak levels of insulin occurred in the first hour in control group, although peak levels of insulin did not occur until the second hour in patients in the orlistat group.
  • Also, serum leptin levels had a more horizontal and delayed increase after a mixed meal in patients in the orlistat group than they did in patients in the placebo group.
  • CONCLUSION: One dose of 120 mg orlistat made no changes in postprandial serum glucose, insulin, and leptin levels, although leptin-level increases were smaller in patients receiving orlistat.
  • [MeSH-major] Hypolipidemic Agents / pharmacology. Lactones / pharmacology. Leptin / blood. Obesity / drug therapy

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  • (PMID = 18846024.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Dietary Carbohydrates; 0 / Dietary Fats; 0 / Dietary Proteins; 0 / Hypolipidemic Agents; 0 / Insulin; 0 / Lactones; 0 / Leptin; 0 / Lipids; 95M8R751W8 / orlistat
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93. Saeed Z, Haleh S, Afsaneh M, Soheila A, Amir Hassan Z, Farah I, Banafsheh T, Elham SS, Narges MB, Mahmood JT: Serum leptin levels in women with immunological recurrent abortion. J Reprod Infertil; 2010 Apr;11(1):47-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels in women with immunological recurrent abortion.
  • Production of such antibodies is under the control of cytokines; and leptin, besides its role in reproductive success, has a profound effect on directing the cytokine profile toward Th1 (cellular) pattern.
  • Therefore, the present study was performed to assess serum leptin levels in women with immunological recurrent abortion.
  • After blood sampling, levels of anti-nuclear antibody (ANA), anti-double stranded DNA antibody (anti-dsDNA), lupus anti-coagulant antibody (LACAb), anti-phospholipid antibody (APA), anti-cardiolipin antibody (ACA), anti-thyroglobulin antibody (TgAb), anti-thyroperoxidase antibody (TPOAb) and anti-thrombin III antibody (ATIIIAb) were measured by enzyme-linked immunosorbent assay (ELISA) or chemiluminescent enzyme immunoassay (CLEIA).
  • With normal level of fasting blood sugar (FBS), IRA and URA groups had similar serum leptin levels (23.7 ± 13.2 ng/ml vs. 22.7 ± 12.5 ng/ml, respectively).
  • Serum leptin concentrations showed a positive correlation with weight and BMI in both groups.
  • CONCLUSION: This study suggests that serum leptin levels are higher in IRA and URA patients than normal women.
  • The findings of this study suggest the need for a more comprehensive study and comparison of leptin levels in IRA and URA patients to women with no history of miscarriages.

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  • (PMID = 23926480.001).
  • [ISSN] 2228-5482
  • [Journal-full-title] Journal of reproduction & infertility
  • [ISO-abbreviation] J Reprod Infertil
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3719276
  • [Keywords] NOTNLM ; Autoantibodies / Immunological / Leptin / Pregnancy / Recurrent abortion / Spontaneous abortion
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94. Takemoto M, Nakashima A, Muneuchi J, Yamamura K, Shiokawa Y, Sunagawa K, Tominaga R: Para-Hisian pacing for a pediatric patient with a congenitally corrected transposition of the great arteries (SLL). Pacing Clin Electrophysiol; 2010 Jan;33(1):e4-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Para-Hisian pacing for a pediatric patient with a congenitally corrected transposition of the great arteries (SLL).
  • We report a pediatric patient with a congenitally corrected transposition of the great arteries (ccTGA)(SLL) in which permanent para-Hisian pacing (PPHP) could improve dyssynchrony-associated systemic ventricular (SV) dysfunction resulting from permanent morphologic left ventricular pacing for complete atrioventricular block.
  • Since, in patients with ccTGA(SLL), an elongated His-bundle runs medially toward the upper septum to the site of the fibrous continuity between the right-sided mitral valve and pulmonary artery, the His-bundle may easily be captured by a pacing lead, unlike in normal hearts.
  • Thus, PPHP may be an effective therapeutic strategy for the treatment of dyssynchrony-associated SV dysfunction associated with ccTGA (SLL).

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  • (PMID = 19793363.001).
  • [ISSN] 1540-8159
  • [Journal-full-title] Pacing and clinical electrophysiology : PACE
  • [ISO-abbreviation] Pacing Clin Electrophysiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Azadbakht L, Esmaillzadeh A: A cross-over trial on soy intake and serum leptin levels in women with metabolic syndrome. J Res Med Sci; 2010 Nov;15(6):317-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A cross-over trial on soy intake and serum leptin levels in women with metabolic syndrome.
  • BACKGROUND: Soy consumption may affect serum leptin levels and exert its beneficial effects in this way.
  • The aim of this study was to evaluate the effect of soy consumption on serum leptin levels in postmenopausal women with metabolic syndrome.
  • Serum leptin level was measured by ELISA method.
  • There was no significant difference between the end values of serum leptin concentrations following these diets (Geometric mean ± SD: 16.9 ± 2.5 ng/ml at the end of control diet, 16.1 ± 1.6 ng/ml at the end of soy protein diet, and 15.9 ± 1.7 ng/ml at the end of soy nut diet).
  • Percent difference compared to control for serum leptin levels showed that neither soy protein nor soy nut diets could significantly alter this variable (p = 0.32).
  • CONCLUSIONS: The results of the present study showed that neither soy protein, nor soy nut could affect weight and serum leptin levels in postmenopausal women with metabolic syndrome.

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  • (PMID = 21526104.001).
  • [ISSN] 1735-7136
  • [Journal-full-title] Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
  • [ISO-abbreviation] J Res Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3082831
  • [Keywords] NOTNLM ; Leptin / Metabolic Syndrome X / Postmenopause / Soy Foods
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96. Karayiannakis AJ, Asimakopoulos B, Efthimiadou A, Tsaroucha AK, Polychronidis A, Simopoulos C: Serum leptin levels and their response during laparoscopic and open cholecystectomy. Eur Cytokine Netw; 2005 Jan-Mar;16(1):91-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum leptin levels and their response during laparoscopic and open cholecystectomy.
  • We compared serum leptin responses during and after laparoscopic and open cholecystectomy, and assessed their correlation with the responses of inflammatory cytokines.
  • Serum levels of leptin, interleukin-1alpha (IL-1alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were measured by an enzyme-linked immunoassay in 31 patients who underwent laparoscopic cholecystectomy and in 24 patients who underwent open cholecystectomy.
  • Serum samples were obtained preoperatively, at 10 and 30 min after the commencement of surgery, and at 6 and 24 h after the operation.
  • The cumulative responses of leptin, IL-1alpha, IL-6 and TNF-alpha to surgery were calculated and the associations between them were evaluated.
  • Serum leptin levels were significantly increased at 24 h after both procedures.
  • The serum leptin concentration at this time point and the cumulative leptin response were significantly lower after laparoscopic cholecystectomy than after open cholecystectomy.
  • Changes in serum IL-1alpha, TNF-alpha and IL-6 concentrations showed similar kinetics in both groups, with postoperative IL-6 levels being consistently lower in the laparoscopic cholecystectomy group.
  • The cumulative responses of leptin, IL-1alpha and IL-6 correlated significantly with each other.
  • Leptin may be involved in the systemic inflammatory response to surgical injury, and the postoperative leptin elevation and cumulative leptin response are significantly lower after laparoscopic cholecystectomy than after open cholecystectomy.
  • [MeSH-major] Cholecystectomy / methods. Cholelithiasis / surgery. Leptin / blood

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  • (PMID = 15809212.001).
  • [ISSN] 1148-5493
  • [Journal-full-title] European cytokine network
  • [ISO-abbreviation] Eur. Cytokine Netw.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Interleukin-1; 0 / Interleukin-6; 0 / Leptin; 0 / Tumor Necrosis Factor-alpha
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97. Liu SQ, Wu J, Mo J, Sun ZX, Yang HB, Huang CW, Lei MX, Peng LW, Xu L: [Serum leptin level and its association with bone mineral density in obese children]. Zhongguo Dang Dai Er Ke Za Zhi; 2009 Sep;11(9):745-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Serum leptin level and its association with bone mineral density in obese children].
  • OBJECTIVE: To investigate serum leptin level and its relationship with bone mineral density in obese children from Changsha City.
  • Serum leptin level was measured using enzyme-linked immunosorbent assay (ELISA).
  • BMD, bone mineral content (BMC), lean mass (LM), fat mass (FM), percentage of body fat (%BF) and leptin concentration in the obesity group were significantly higher than those in the normal group (p<0.01).
  • Serum leptin level was positively correlated with BMD, BMC, LM and FM (r=0.528-0.903, p<0.01).
  • Multiple stepwise regression analysis indicated that BMI and %BF were independent influencing factors for serum leptin level.
  • CONCLUSIONS: Obese children have higher serum leptin level.
  • Serum leptin concentration is significantly correlated with BMD and body composition.
  • BMI and %BF are independent influencing factors for serum leptin level in children.
  • [MeSH-major] Bone Density. Leptin / blood. Obesity / blood

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  • (PMID = 19755025.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Leptin
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98. Larkin EK, Elston RC, Patel SR, Tishler PV, Palmer LJ, Jenny NS, Redline S: Linkage of serum leptin levels in families with sleep apnea. Int J Obes (Lond); 2005 Mar;29(3):260-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linkage of serum leptin levels in families with sleep apnea.
  • OBJECTIVE: To identify regions on the genome linked to plasma leptin levels.
  • MEASUREMENTS: Serum leptin levels adjusted for age, sex, race and body mass index (BMI).
  • Linkage was generally stronger after BMI adjustment, suggesting the potential influence of a number of metabolic pathways on leptin levels other than those that directly determine obesity levels.
  • The evidence of linkage for leptin levels is consistent with prior linkage analyses for cholesterol, hypertension and other metabolic phenotypes.
  • [MeSH-major] Genetic Linkage. Leptin / genetics. Sleep Apnea Syndromes / genetics

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  • (PMID = 15611783.001).
  • [ISSN] 0307-0565
  • [Journal-full-title] International journal of obesity (2005)
  • [ISO-abbreviation] Int J Obes (Lond)
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM28356; United States / NCRR NIH HHS / RR / M01-RR00080; United States / NHLBI NIH HHS / HL / R01HL46380; United States / NCRR NIH HHS / RR / RR03655; United States / NHLBI NIH HHS / HL / T32-HL07567
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leptin
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99. Ahamadi F, Bosorgmehr R, Razeghi E: Relationship between serum leptin level and laboratory and anthropometric indices of malnutrition in patients on hemodialysis. Indian J Nephrol; 2008 Jul;18(3):105-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship between serum leptin level and laboratory and anthropometric indices of malnutrition in patients on hemodialysis.
  • There is no single index in evaluation of nutritional status in these patients, so leptin can be used as one of the parameters.
  • In this study, the correlation between serum leptin with biochemical and anthropometric parameters of nutrition has been evaluated.
  • Malnutrition laboratory parameters and serum leptin were measured before hemodialysis.
  • Serum leptin was measured with enzyme-linked immunosorbent assay (ELISA) method with direct dbc kit and malnutrition laboratory parameters measured with standard laboratory methods, patients anthropometric parameters evaluated after hemodialysis.
  • The mean age of patients was 47.5 +/- 16.1 years and the range of serum leptin level was 0.6-64.8 ng/ml.
  • Mean serum leptin level were 22.64 +/- 19.54 ng/ml in females and 16.74 +/- 20.16 ng/ml in males on hemodialysis and in spite of higher level of leptin in females there was not any statistically significant difference between females and males serum leptin.
  • Absolute value of correlation coefficient between serum leptin and anthropometric parameters and most laboratory parameters was < 0.25 (except ferritin, iron, phosphorous in males and total protein, hemoglobin, urea, and creatinin in females which was between 0.25 and 0.50).
  • Our results suggest that the increased serum leptin level does not have a major role in diagnosis of malnutrition in hemodialysis patients and there is a poor correlation between malnutrition parameters and serum leptin level.

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  • (PMID = 20142915.001).
  • [ISSN] 1998-3662
  • [Journal-full-title] Indian journal of nephrology
  • [ISO-abbreviation] Indian J Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2813131
  • [Keywords] NOTNLM ; Anthropometric parameters / hemodialysis / leptin / malnutrition
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100. Hung SC, Tung TY, Yang CS, Tarng DC: High-calorie supplementation increases serum leptin levels and improves response to rHuEPO in long-term hemodialysis patients. Am J Kidney Dis; 2005 Jun;45(6):1073-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-calorie supplementation increases serum leptin levels and improves response to rHuEPO in long-term hemodialysis patients.
  • Leptin, a hormone secreted by adipocytes, may have a role in protecting against renal anemia.
  • The aim of the present study is to determine the effect of an increase in serum leptin levels by increasing energy intake on recombinant human erythropoietin (rHuEPO) response in long-term hemodialysis (HD) patients.
  • METHODS: We enrolled 65 long-term HD patients to explore the association between leptin level and rHuEPO response by classifying them as either high- or low-leptin individuals (phase 1).
  • Serial serum leptin levels, nutritional measures, and hematologic parameters were obtained.
  • Age- and sex-matched well-nourished patients (group C; n = 16) not administered extra nutritional supplementation served as control subjects (phase 2).
  • RESULTS: In phase 1, a significantly lower erythropoietin dose, greater hematocrit, and better nutritional measures were observed in the high-leptin group (P < 0.001).
  • In phase 2, there was a significant increase in body fat mass (P = 0.001) and median serum leptin levels (P < 0.001) in response to 12 weeks of high-energy supplementation in group A, accompanied by markedly improved erythropoiesis (P < 0.05) compared with groups B and C.
  • Increasing energy intake improves erythropoiesis, which may be mediated in part by an increase in serum leptin levels.
  • [MeSH-major] Anemia / prevention & control. Dietary Proteins / administration & dosage. Dietary Supplements. Energy Intake. Erythropoiesis. Erythropoietin / therapeutic use. Kidney Failure, Chronic / complications. Leptin / blood. Renal Dialysis

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  • (PMID = 15957137.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Proteins; 0 / Hemoglobins; 0 / Leptin; 0 / Recombinant Proteins; 0 / epoetin beta; 11096-26-7 / Erythropoietin
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