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1. Gitelson E, Al-Saleem T, Robu V, Millenson MM, Smith MR: Pediatric nodal marginal zone lymphoma may develop in the adult population. Leuk Lymphoma; 2010 Jan;51(1):89-94
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  • [Title] Pediatric nodal marginal zone lymphoma may develop in the adult population.
  • Pediatric nodal marginal zone lymphoma (NMZL) is described as a separate variant of NMZL in the most recent WHO classification of tumors of hematologic and lymphoid tissues.
  • Here we report two adult patients with NMZL with clinical and morphologic features consistent with pediatric NMZL (pNMZL) and review available literature describing the clinical and histologic presentation of pNMZL.
  • Two men, ages 44 and 18 years, each presented with localized cervical lymphadenopathy, both demonstrated florid proliferation of the marginal zone and disruption of reactive germinal centers, progressive transformation of germinal centers-like morphologic features typical for pNMZL and clonal disease with immunophenotype consistent with NMZL.

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  • (PMID = 19863176.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA071552-03; United States / NCI NIH HHS / CA / R01 CA071552-03
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 4F4X42SYQ6 / Rituximab
  • [Other-IDs] NLM/ NIHMS213585; NLM/ PMC3572776
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2. Ratnarathorn M, Newman J: Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) occurring in association with nodal marginal zone lymphoma: a case report. Dermatol Online J; 2008;14(8):6
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  • [Title] Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) occurring in association with nodal marginal zone lymphoma: a case report.
  • Sneddon-Wilkinson disease or subcorneal pustular dermatosis (SPD) is a rare, benign inflammatory skin disorder of unknown etiology.
  • Herein, we report the first case of SPD in association with marginal zone lymphoma.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / complications. Skin Diseases, Vesiculobullous / diagnosis
  • [MeSH-minor] Acitretin / adverse effects. Acitretin / therapeutic use. Anemia / etiology. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colchicine / therapeutic use. Diagnosis, Differential. Drug Therapy, Combination. Female. Fluocinonide / therapeutic use. Humans. Middle Aged. Neutropenia / chemically induced. Prednisone / therapeutic use. Rituximab

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  • (PMID = 19061566.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 2W4A77YPAN / Fluocinonide; 4F4X42SYQ6 / Rituximab; LCH760E9T7 / Acitretin; SML2Y3J35T / Colchicine; VB0R961HZT / Prednisone
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3. Aftab K, Bhurgri Y, Pervez S: Small B cell Non-Hodgkins Lymphoma in Pakistan. J Pak Med Assoc; 2006 Jan;56(1):22-5
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  • [Title] Small B cell Non-Hodgkins Lymphoma in Pakistan.
  • OBJECTIVE: To study the pattern of small B cell lymphomas in Pakistan.
  • METHODS: This descriptive study was carried out at the Aga Khan University Hospital pathology department including 1721 cases of Non-Hodgkins Lymphoma (NHL) diagnosed during a period of five years (1998-2002) and classified according to REAL/WHO classification.
  • RESULTS: Out of the 1721 NHL cases, only 140 (8.1%) could be categorized as small B-cell NHL.
  • The study group comprised small lymphocytic lymphoma/chronic lymphocytic leukemia (58 cases; 41.4%) followed by follicular lymphoma (46 cases; 32.9%), mantle cell lymphoma (15 cases; 10.7%), extra nodal marginal zone B cell lymphoma of MALT type (15 cases; 10.7%), lymphoplasmacytic lymphoma (5 cases; 3.6%) and splenic marginal zone B-cell lymphoma (1 case; 0.7%).
  • No case of nodal marginal zone lymphoma was diagnosed.
  • Small B-cell NHL was more common in males; with male to female ratio of 2.1.
  • Majority of the small B-cell NHL were nodal at presentation with a nodal to extranodal ratio of 3.4.
  • CONCLUSION: It is concluded that the frequency of these small B-cell NHL is very low in our population in contrast to the western literature.
  • Further studies based on epidemiologic and etiological factors are required to look into this marked difference of occurrence of these indolent lymphomas.
  • [MeSH-major] Leukemia, Lymphocytic, Chronic, B-Cell / epidemiology

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  • (PMID = 16454131.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Pakistan
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4. Aggarwal M, Villuendas R, Gomez G, Rodriguez-Pinilla SM, Sanchez-Beato M, Alvarez D, Martinez N, Rodriguez A, Castillo ME, Camacho FI, Montes-Moreno S, Garcia-Marco JA, Kimby E, Pisano DG, Piris MA: TCL1A expression delineates biological and clinical variability in B-cell lymphoma. Mod Pathol; 2009 Feb;22(2):206-15
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  • [Title] TCL1A expression delineates biological and clinical variability in B-cell lymphoma.
  • The assembly of a collection of gene-expression signatures of the major types of B-cell non-Hodgkin's lymphoma has identified increased T-cell leukemia/lymphoma 1A (TCL1) expression in multiple lymphoma types and cases, and has enabled the investigation of the functional and clinical importance of TCL1 expression.
  • Specifically, Burkitt's lymphoma cases show a homogeneously strong expression of TCL1, whereas diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, nodal marginal zone lymphoma, and splenic marginal zone lymphoma display a striking variability in the intensity of TCL1 staining.
  • A Gene-Set Enrichment Analysis of the genes correlated with TCL1A expression found that variation in the level of expression of TCL1A was significantly associated with some of the most important gene signatures recognizing B-cell lymphoma pathogenesis and heterogeneity, such as germinal center, B-cell receptor, NF-kappaB (and its target genes), death, MAP kinases, TNFR1, TOLL, and IL1R.
  • Additionally, TCL1 expression was correlated with shorter time to treatment in chronic lymphocytic leukemia cases and shorter lymphoma-specific survival in mantle cell lymphoma series, thus indicating the clinical and biological significance of TCL1 expression, and suggesting TCL1A as a potential therapeutic target.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Lymphoma, B-Cell / genetics. Lymphoma, Non-Hodgkin / genetics. Proto-Oncogene Proteins / genetics
  • [MeSH-minor] Aged. Female. Gene Expression Profiling / methods. Gene Regulatory Networks. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Leukemia, Lymphocytic, Chronic, B-Cell / genetics. Lymphoma, Mantle-Cell / genetics. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Prognosis. Reproducibility of Results. Tissue Array Analysis

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  • (PMID = 18820675.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / TCL1A protein, human
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5. Baraboutis IG, Marinos L, Lekakis LJ, Papastamopoulos V, Georgiou O, Tsagalou EP, Rondogianni P, Apostolidis J, Papadaki T, Skoutelis AT: Long-term complete regression of nodal marginal zone lymphoma transformed into diffuse large B-cell lymphoma with highly active antiretroviral therapy alone in human immunodeficiency virus infection. Am J Med Sci; 2009 Dec;338(6):517-21
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  • [Title] Long-term complete regression of nodal marginal zone lymphoma transformed into diffuse large B-cell lymphoma with highly active antiretroviral therapy alone in human immunodeficiency virus infection.
  • Since the introduction of combination antiretroviral therapy (cART), there has been a decrease in the incidence of non-Hodgkin lymphoma among the HIV-infected population and also significantly improved survival rates.
  • We describe a remarkable case of a HIV-infected patient whose large B-cell lymphoma, most likely arising by transformation of a nodal marginal zone lymphoma, completely regressed with the use of cART alone.
  • He remained disease-free for almost 3 years and he finally died from presumed flare up of his lymphoma.
  • There are very few cases of spontaneous regression of lymphomas with cART alone in the HIV population.
  • This is an extreme example of the significance of cART in improving survival in HIV-non-Hodgkin lymphoma and changing the face of the HIV epidemic in general.
  • [MeSH-major] Antiretroviral Therapy, Highly Active. Lymphoma, AIDS-Related / drug therapy. Lymphoma, B-Cell, Marginal Zone / complications. Lymphoma, B-Cell, Marginal Zone / drug therapy. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / drug therapy

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  • (PMID = 20010159.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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6. Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, Suzumiya J, Harada M, Kikuchi M: A "floral" variant of nodal marginal zone lymphoma. Hum Pathol; 2005 Feb;36(2):202-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A "floral" variant of nodal marginal zone lymphoma.
  • We describe 6 cases of a specific variant of nodal marginal zone lymphoma with "floral" lymph follicles in patients ranging in age from 18 to 66 years.
  • Histologically, all lesions had a distinctive morphology, with proliferation of medium-sized atypical lymphoid cells in the marginal zone, hyperplastic lymph follicles with enlarged germinal centers, and a thickened mantle zone.
  • On immunohistochemical staining, the atypical lymphoid cells showed a B-cell phenotype (CD20 +), IgM positivity in 2 of 5 cases, and negativity for CD5, CD10, CD23, CD43, bcl-6, and IgD.
  • This variant should be differentiated from the usual nodal marginal zone lymphoma because of its specific clinical and pathological features.
  • [MeSH-major] Germinal Center / pathology. Lymph Nodes / pathology. Lymphoma, B-Cell / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. DNA, Neoplasm / analysis. Female. Humans. Hyperplasia. Immunoglobulin Heavy Chains / genetics. Immunoglobulin M / analysis. Immunoglobulin Variable Region / drug effects. Immunohistochemistry. Lymphatic Diseases. Male. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 15754298.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Immunoglobulin Heavy Chains; 0 / Immunoglobulin M; 0 / Immunoglobulin Variable Region
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7. Kanellis G, Roncador G, Arribas A, Mollejo M, Montes-Moreno S, Maestre L, Campos-Martin Y, Ríos Gonzalez JL, Martinez-Torrecuadrada JL, Sanchez-Verde L, Pajares R, Cigudosa JC, Martin MC, Piris MA: Identification of MNDA as a new marker for nodal marginal zone lymphoma. Leukemia; 2009 Oct;23(10):1847-57

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of MNDA as a new marker for nodal marginal zone lymphoma.
  • Clinical and biological studies on nodal marginal zone lymphoma (NMZL) are hampered by the lack of specific diagnostic markers and the low reproducibility of this diagnosis.
  • A comparative expression-profiling study has shown a set of markers to be differentially expressed in NMZL compared with follicular lymphoma (FL), including myeloid cell nuclear differentiation antigen (MNDA), a nuclear protein expressed by myeloid cells and a subset of B-cells.
  • The aim of this study was to characterize the expression of MNDA in normal and reactive human tissue, and in a large series of non-Hodgkin's B-cell lymphomas, with particular emphasis on NMZL and FL.
  • Our results showed that MNDA is expressed in normal tissue by a subset of the marginal zone B cells.
  • They also showed MNDA expression in subgroups of chronic lymphocytic leukemia, mantle-cell lymphoma, and diffuse large B-cell lymphoma, but MNDA was especially expressed by lymphomas derived from the marginal zone, such as mucosa-associated lymphoid-tissue lymphoma, splenic marginal-zone lymphoma and NMZL.
  • [MeSH-major] Antigens, Differentiation, Myelomonocytic / metabolism. Biomarkers, Tumor / metabolism. Lymphoma, B-Cell, Marginal Zone / metabolism. Lymphoma, Follicular / metabolism. Transcription Factors / metabolism

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  • (PMID = 19474799.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / Immunoglobulin G; 0 / MNDA protein, human; 0 / Transcription Factors
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8. Salama ME, Lossos IS, Warnke RA, Natkunam Y: Immunoarchitectural patterns in nodal marginal zone B-cell lymphoma: a study of 51 cases. Am J Clin Pathol; 2009 Jul;132(1):39-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoarchitectural patterns in nodal marginal zone B-cell lymphoma: a study of 51 cases.
  • Nodal marginal zone lymphoma (NMZL) represents a rare and heterogeneous group that lacks markers specific for the diagnosis.
  • We evaluated morphologic and immunoarchitectural features of 51 NMZLs, and the following immunostains were performed: CD20, CD21, CD23, CD5, CD3, CD43, CD10, Ki-67, BCL1, BCL2, BCL6, HGAL, and LMO2.
  • Four immunoarchitectural patterns were evident: diffuse (38 [75%]), well-formed nodular/follicular (5 [10%]), interfollicular (7 [14%]), and perifollicular (1 [2%]).
  • Additional features included a monocytoid component (36 [71%]), admixed large cells (20 [39%]), plasma cells (24 [47%]), compartmentalizing stromal sclerosis (13 [25%]), and prominent blood vessel sclerosis (10 [20%]).
  • CD21 highlighted disrupted follicular dendritic cell meshwork in 35 (71%) of 49 cases, and CD43 coexpression was present in 10 (24%) of 42 cases.
  • A panel of germinal center-associated markers was helpful in eliminating cases of diffuse follicle center lymphoma.
  • Our results highlight the histologic and immunoarchitectural spectrum of NMZL and the usefulness of immunohistochemical analysis for CD43, CD23, CD21, BCL6, HGAL, and LMO2 in the diagnosis of NMZL.

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  • (PMID = 19864232.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P0I CA34233; United States / NCI NIH HHS / CA / P01 CA034233; United States / NCI NIH HHS / CA / R01 CA109335-05; United States / NCI NIH HHS / CA / CA122105; United States / NCI NIH HHS / CA / CA109335-05; United States / NCI NIH HHS / CA / R01 CA109335; United States / NCI NIH HHS / CA / R01 CA122105; United States / NCI NIH HHS / CA / CA109335
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS207789; NLM/ PMC2894708
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9. Rodig SJ, Healey BM, Pinkus GS, Kuo FC, Dal Cin P, Kutok JL: Mantle cell lymphoma arising within primary nodal marginal zone lymphoma: a unique presentation of two uncommon B-cell lymphoproliferative disorders. Cancer Genet Cytogenet; 2006 Nov;171(1):44-51
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  • [Title] Mantle cell lymphoma arising within primary nodal marginal zone lymphoma: a unique presentation of two uncommon B-cell lymphoproliferative disorders.
  • Mantle cell lymphoma and primary nodal marginal zone lymphoma are uncommon tumors thought to arise within discrete anatomic compartments of the B-cell follicle.
  • We report an unusual composite lymphoma comprised of these two neoplasms within an isolated lymph node in a 72-year-old woman.
  • The tumors were distinguished by a combination of morphologic, phenotypic, and cytogenetic findings, and the presence of dual, unrelated neoplasms was confirmed by molecular diagnostic studies.
  • These findings underscore the unique characteristics of these B-cell tumors and support the notion that early in disease development both neoplasms are confined to the distinct anatomic compartments of their postulated normal B-cell counterparts.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Mantle-Cell / pathology

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  • (PMID = 17074590.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD43; 0 / Antigens, CD5; 0 / Immunoglobulin Heavy Chains; 136601-57-5 / Cyclin D1
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10. Arcaini L, Lucioni M, Boveri E, Paulli M: Nodal marginal zone lymphoma: current knowledge and future directions of an heterogeneous disease. Eur J Haematol; 2009 Sep;83(3):165-74
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  • [Title] Nodal marginal zone lymphoma: current knowledge and future directions of an heterogeneous disease.
  • Nodal marginal zone lymphoma (NMZL) is a defined, separate clinicopathological entity.
  • NMZL is a B-cell neoplasm originated in the lymph node, whose histology resembles the nodal infiltration by mucosa-associated lymphoid tissue- or splenic-type marginal zone lymphoma, in the absence of clinical evidence of extranodal or spleen disease.
  • The lack of characteristic phenotypic or molecular diagnostic findings is still hampering the reproducibility of this diagnosis.
  • We also summarize the clinical features and outcome of this rare lymphoma and we discuss the possible association with hepatitis C virus infection.
  • [MeSH-major] Hepatitis C / complications. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, B-Cell, Marginal Zone / therapy. Medical Oncology / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunophenotyping / methods. Male. Middle Aged. Neoplasm Staging / methods. Treatment Outcome

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  • (PMID = 19548917.001).
  • [ISSN] 1600-0609
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 59
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11. Mollejo M, Camacho FI, Algara P, Ruiz-Ballesteros E, García JF, Piris MA: Nodal and splenic marginal zone B cell lymphomas. Hematol Oncol; 2005 Sep-Dec;23(3-4):108-18
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  • [Title] Nodal and splenic marginal zone B cell lymphomas.
  • Splenic marginal zone lymphoma (SMZL) and nodal marginal zone lymphoma (NMZL) are newly defined, separate clinicopathological entities.
  • Both are rare lymphoma types, with low reproducibility in the diagnosis, although a conjunction of molecular and clinical studies seems to be now facilitating a more accurate diagnosis and understanding of the neoplastic process.
  • The diagnosis has been until very recently based on the pathological study of the spleen with the conjunction of the clinical features, although the integration of the morphology in bone marrow and peripheral blood with the immunophenotype and molecular characteristics of the tumour makes a more accurate diagnosis now possible.
  • SMZL is an indolent lymphoma, although there is small subset of patients in which it follows an aggressive course.
  • Nodal marginal zone lymphoma is a B-cell neoplasm originated in the lymph node, whose histology resembles the nodal infiltration by MALT- or Splenic-type marginal zone lymphoma, in the absence of clinical evidence of extranodal or spleen disease.
  • The lack of characteristic phenotypic or molecular diagnostic findings is still hampering the reproducibility of this diagnosis.
  • Here we review the main morphological and immunophenotypical markers, discussing the differential with other overlapping entities, singularly follicular lymphoma.
  • [MeSH-major] Biomarkers, Tumor / genetics. Chromosomes, Human, Pair 7 / genetics. Lymphoma, B-Cell / genetics. Lymphoma, Follicular / genetics. Splenic Neoplasms / genetics
  • [MeSH-minor] Humans. Loss of Heterozygosity / genetics. Lymph Nodes / pathology. Prognosis. Spleen / pathology

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  • [Copyright] 2005 John Wiley & Sons, Ltd.
  • (PMID = 16307458.001).
  • [ISSN] 0278-0232
  • [Journal-full-title] Hematological oncology
  • [ISO-abbreviation] Hematol Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 66
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12. Boveri E, Arcaini L, Merli M, Passamonti F, Rizzi S, Vanelli L, Rumi E, Rattotti S, Lucioni M, Picone C, Castello A, Pascutto C, Magrini U, Lazzarino M, Paulli M: Bone marrow histology in marginal zone B-cell lymphomas: correlation with clinical parameters and flow cytometry in 120 patients. Ann Oncol; 2009 Jan;20(1):129-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone marrow histology in marginal zone B-cell lymphomas: correlation with clinical parameters and flow cytometry in 120 patients.
  • BACKGROUND: Among marginal zone lymphomas (MZLs), bone marrow (BM) involvement features are well established in the splenic marginal zone lymphoma (SMZL); few data are available for extranodal marginal zone lymphoma (EMZL) and nodal marginal zone lymphoma (NMZL).
  • RESULTS: At diagnosis, BM involvement occurs in 90% SMZL, 22% EMZL and 54% NMZL (P<0.0001); at reevaluation, incidence raises to 96% in SMZL and 34% in EMZL.

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  • (PMID = 18718888.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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13. Ferreri AJ, Zucca E: Marginal-zone lymphoma. Crit Rev Oncol Hematol; 2007 Sep;63(3):245-56
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  • [Title] Marginal-zone lymphoma.
  • The term marginal-zone lymphoma (MZL) encompasses three closely related lymphoma subtypes, namely the "low-grade B-cell lymphoma of MALT type" currently named MALT lymphoma, the "nodal marginal-zone B-cell lymphoma" and a provisional entity in the REAL classification named "primary splenic MZL with or without villous lymphocytes".
  • These entities display different characteristics, with evident clinical and biological variations according to the organ where the lymphoma arises.
  • Marginal-zone B-cells are functionally heterogeneous and may differ with respect to the pattern of somatic hypermutation in their Ig variable genes.
  • Sequence and mutation analysis of the rearranged Ig heavy chain variable genes and that somatic mutations pattern indicate that MZL may arise from different subsets of marginal-zone B-cells.
  • Pathogenesis of these groups of lymphomas is correlated to chronic infections, like Helicobacter pylori, hepatitis C virus, Campylobacter jejuni, Chlamydia psittaci and Borrelia burgdorferi.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, B-Cell, Marginal Zone / therapy

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  • (PMID = 17583528.001).
  • [ISSN] 1040-8428
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 114
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14. Arcaini L, Bruno R: Hepatitis C virus infection and antiviral treatment in marginal zone lymphomas. Curr Clin Pharmacol; 2010 May;5(2):74-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatitis C virus infection and antiviral treatment in marginal zone lymphomas.
  • The association between hepatitis C virus (HCV) infection and B-cell non-Hodgkin's lymphomas has been demonstrated in epidemiological studies, in particular in highly endemic geographical areas such as Italy, Japan and southern parts of United States.
  • Marginal zone lymphomas are the histotypes that are most frequently associated with HCV infection.
  • The WHO classification comprises extranodal marginal zone B-cell lymphoma of MALT type, splenic marginal zone B-cell lymphoma and nodal marginal zone B-cell lymphoma.
  • Recently, antiviral treatment has been proved to be effective in the treatment of HCV-positive patients with indolent lymphoma, prevalently of marginal zone origin.
  • This is the strongest evidence of a causative link between HCV and lymphomas.
  • Aim of this review is to illustrate the relationship between HCV infection and marginal zone lymphomas and to systematically summarize the data from the therapeutic studies where antiviral treatment with alpha-interferon with or without ribavirin was employed in patients with marginal zone lymphomas.
  • [MeSH-major] Antiviral Agents / therapeutic use. Hepatitis C / drug therapy. Lymphoma, B-Cell, Marginal Zone / drug therapy

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  • (PMID = 20156155.001).
  • [ISSN] 2212-3938
  • [Journal-full-title] Current clinical pharmacology
  • [ISO-abbreviation] Curr Clin Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United Arab Emirates
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha; 49717AWG6K / Ribavirin
  • [Number-of-references] 87
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15. Rizzo KA, Streubel B, Pittaluga S, Chott A, Xi L, Raffeld M, Jaffe ES: Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCR. Mod Pathol; 2010 Jun;23(6):866-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCR.
  • Marginal zone lymphomas present rarely in children and young adults as either primary nodal or extranodal disease and have an excellent prognosis.
  • We undertook a study to analyze genetic alterations in nodal and extranodal marginal zone lymphomas in children and young adults using fluorescence in situ hybridization (FISH) and RT-PCR.
  • 73% of the marginal zone lymphoma cases showed evidence of light chain restriction by immunohistochemistry or flow cytometry.
  • 85% of the marginal zone lymphoma cases tested showed evidence of immunoglobulin heavy chain gene rearrangement.
  • Fifty-nine percent of the cases were nodal marginal zone lymphomas with a median age at presentation of 16 years and an M/F ratio of 7:1.
  • Twenty-one percent of the nodal marginal zone lymphoma cases contained genetic aberrations.
  • Forty-one percent of the cases were extranodal marginal zone lymphomas with a median age of 24 years and a M/F ratio of 1.4:1.
  • Eighteen percent of the extranodal marginal zone lymphoma cases contained genetic aberrations.
  • Overall the incidence of genetic aberrations in marginal zone lymphomas in the pediatric and young adult population is low, but the aberrations seen are similar to those seen in the adult population.
  • [MeSH-major] Chromosome Aberrations. Gene Expression Regulation, Neoplastic. In Situ Hybridization, Fluorescence. Lymphoma, B-Cell, Marginal Zone / genetics. Reverse Transcriptase Polymerase Chain Reaction
  • [MeSH-minor] Adolescent. Antigens, CD43 / analysis. Caspases / genetics. Child. Child, Preschool. Female. Flow Cytometry. Gene Rearrangement. Genes, Immunoglobulin Heavy Chain. Humans. Immunoglobulin Light Chains / analysis. Immunohistochemistry. Immunophenotyping. Infant. Male. Neoplasm Proteins / genetics. Translocation, Genetic. Young Adult

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  • (PMID = 20305621.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD43; 0 / Immunoglobulin Light Chains; 0 / Neoplasm Proteins; 0 / UN1 sialoglycoprotein, human; EC 3.4.22.- / Caspases; EC 3.4.22.- / MALT1 protein, human
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16. Traverse-Glehen A, Felman P, Callet-Bauchu E, Gazzo S, Baseggio L, Bryon PA, Thieblemont C, Coiffier B, Salles G, Berger F: A clinicopathological study of nodal marginal zone B-cell lymphoma. A report on 21 cases. Histopathology; 2006 Jan;48(2):162-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathological study of nodal marginal zone B-cell lymphoma. A report on 21 cases.
  • AIMS: To report the clinicopathological findings of 21 cases of primary nodal marginal zone B-cell lymphoma (NMZL).
  • NMZL is a recently characterized lymphoma and few series have been published.
  • METHODS AND RESULTS: The clinical data were characteristic of a disseminated disease at presentation: presence of peripheral and abdominal lymph nodes, bone marrow involvement (62%), disease stage III and IV (76%), elevated lactate dehydrogenase (LDH) (48%).
  • Morphological features were heterogeneous and there were some differences compared with other marginal zone B-cell lymphomas (MZL).
  • Pure monocytoid B-cell lymphomas were rare (10%) but a minor component of monocytoid B cell was observed more frequently (23%).
  • [MeSH-major] Lymphoma, B-Cell / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD20 / analysis. Bone Marrow / pathology. DNA-Binding Proteins / analysis. Female. Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics. Humans. Immunohistochemistry. Karyotyping. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Staging. Proto-Oncogene Proteins c-bcl-2 / analysis. Survival Analysis. Translocation, Genetic

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  • (PMID = 16405665.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / BCL6 protein, human; 0 / DNA-Binding Proteins; 0 / Proto-Oncogene Proteins c-bcl-2
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17. Kojima M, Inagaki H, Motoori T, Itoh H, Shimizu K, Tamaki Y, Murase T, Nakamura S: Clinical implications of nodal marginal zone B-cell lymphoma among Japanese: study of 65 cases. Cancer Sci; 2007 Jan;98(1):44-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical implications of nodal marginal zone B-cell lymphoma among Japanese: study of 65 cases.
  • To clarify the clinical presentation and outcome of nodal marginal zone B-cell lymphoma (NMZBL), 65 Japanese patients with this disease were studied and compared with the published literature from western countries.
  • However, the 65 patients in this series exhibited relatively longer 5-year overall survival (85%) and failure-free survival (60%) than the NMZBL series published in western literature, suggesting that NMZBL should be classified as indolent lymphoma.
  • (3) mucosa-associated lymphoid tissue (MALT) type (n = 29); and (4) diffuse large B-cell lymphoma (DLBCL) + MALT type (n = 20).
  • [MeSH-major] Lymphoma, B-Cell
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Asian Continental Ancestry Group. Diagnosis, Differential. Female. Humans. Lymphoma, B-Cell, Marginal Zone / classification. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, B-Cell, Marginal Zone / pathology. Male. Middle Aged. Sex Factors. Survival Analysis

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  • (PMID = 17052258.001).
  • [ISSN] 1347-9032
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Kojima M, Motoori T, Iijima M, Ono T, Yoshizumi T, Matsumoto M, Masawa N, Nakamura S: Florid monocytoid B-cell hyperplasia resembling nodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue type. A histological and immunohistochemical study of four cases. Pathol Res Pract; 2006;202(12):877-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Florid monocytoid B-cell hyperplasia resembling nodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue type. A histological and immunohistochemical study of four cases.
  • A pale ring of medium-to-large cells surrounding the follicles, namely a marginal zone distribution pattern, is the key criterion for diagnosing nodal marginal zone B-cell lymphoma (NMZBL).
  • The tumor cells of NMZBL occasionally exhibit the morphology of monocytoid B-cells (MBC).
  • Recognition of this unusual MBC hyperplasia in reactive lymph node lesions is important to avoid confusion with NMZBLs.
  • [MeSH-major] B-Lymphocytes / pathology. Germinal Center / pathology. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Pseudolymphoma / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Lymphatic Diseases / pathology. Male. Middle Aged

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  • (PMID = 16989959.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Naresh KN: Nodal marginal zone B-cell lymphoma with prominent follicular colonization - difficulties in diagnosis: a study of 15 cases. Histopathology; 2008 Feb;52(3):331-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodal marginal zone B-cell lymphoma with prominent follicular colonization - difficulties in diagnosis: a study of 15 cases.
  • AIMS: While colonization of reactive follicles is well described in mucosa-associated lymphoid tissue lymphoma, this is not fully appreciated in nodal marginal zone B-cell lymphoma (NMZL).
  • In contrast, the colonizing marginal zone lymphoma cells expressed CD20, Bcl-2 and often MUM1 and were negative for Bcl-6 and CD10.
  • In none except one was the referring diagnosis NMZL.
  • CONCLUSION: Recognizing and appreciating follicular colonization in a subset of NMZLs, appropriate use of immunohistochemistry and knowledge of immunohistological features can aid in making the correct diagnosis.
  • [MeSH-major] Lymph Nodes / pathology. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, Follicular / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18269584.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Zhang YN, Zhou XG, Zhang SH, Zheng YY, Liu WH: [Nodal marginal zone B-cell lymphoma: a clinicopathologic study of 10 cases]. Zhonghua Bing Li Xue Za Zhi; 2007 Aug;36(8):529-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Nodal marginal zone B-cell lymphoma: a clinicopathologic study of 10 cases].
  • OBJECTIVE: To study the morphologic features, immunophenotype, differential diagnosis and prognosis of nodal marginal zone B-cell lymphoma (NMZL).
  • RESULTS: All cases presented with good performance status at the time of diagnosis.
  • The lymphoma was composed predominantly of atypical lymphoid cells resembling centrocytes (7/10).
  • A predominance of monocytoid B-cell (2/10) or small lymphocytic (1/10) morphology was rare.
  • Instead, the presence of a minor component of monocytoid B cells was not uncommon (5/10).
  • Differential diagnosis includes lymphoplasmacytic lymphoma, lymph node involvement by extranodal marginal zone B-cell lymphoma and T-zone hyperplasia.
  • [MeSH-major] Lymph Nodes / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Proto-Oncogene Proteins c-bcl-2 / metabolism
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Remission Induction. Survival Rate. Waldenstrom Macroglobulinemia / pathology

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  • (PMID = 17980100.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
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21. Haas RL, Poortmans P, de Jong D, Verheij M, van der Hulst M, de Boer JP, Bartelink H: Effective palliation by low dose local radiotherapy for recurrent and/or chemotherapy refractory non-follicular lymphoma patients. Eur J Cancer; 2005 Aug;41(12):1724-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effective palliation by low dose local radiotherapy for recurrent and/or chemotherapy refractory non-follicular lymphoma patients.
  • In this work, we have studied the response rates and duration of response after low-dose (4 Gy) involved field radiotherapy (LD-IF-RT) in relapsed or chemotherapy refractory indolent and aggressive lymphoma patients.
  • Patients included were those with small lymphocytic lymphoma/chronic lymphocytic leukaemia (n=23), marginal zone lymphoma, nodal type (n=18), mantle cell lymphoma (n=17), and diffuse large B-cell lymphoma (n=13).
  • Median time since diagnosis was 31 months (range 1-216 months).
  • None of the factors studied (age, sex, lymphoma subtype, radiotherapy regimen, number of prior regimens or time since diagnosis, number of positive sites or largest lymphoma diameter) were found to relate to response.
  • It appears that LD-IF-RT is a valuable asset in the management of relapsed disease in both indolent and aggressive lymphoma and should be considered to palliate symptoms in patients with recurrent and/or chemotherapy refractory disease.
  • [MeSH-major] Lymphoma / radiotherapy. Palliative Care / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Disease-Free Survival. Drug Resistance, Neoplasm. Humans. Male. Middle Aged. Prospective Studies. Radiotherapy / adverse effects. Recurrence. Treatment Outcome

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  • (PMID = 16039113.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Oh SY, Ryoo BY, Kim WS, Kim K, Lee J, Kim HJ, Kwon JM, Lee HR, Ko YH, Oh SJ, Park KW, Kim HJ, Kwon HC, Nam E, Kim JH, Park YH, Lee SS, Kim HY, Park K: Nodal marginal zone B-cell lymphoma: Analysis of 36 cases. Clinical presentation and treatment outcomes of nodal marginal zone B-cell lymphoma. Ann Hematol; 2006 Nov;85(11):781-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodal marginal zone B-cell lymphoma: Analysis of 36 cases. Clinical presentation and treatment outcomes of nodal marginal zone B-cell lymphoma.
  • Nodal marginal zone B-cell lymphoma (NMZL) is a relatively uncommon type of lymphoma.
  • Most patients were categorized as low or low-intermediate risk group by international prognostic index (IPI) (77.1%).
  • The significant predictive factors for PFS were performance status, advanced stage, and follicular lymphoma IPI (FLIPI) in this study.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Anthracyclines / therapeutic use. Antineoplastic Agents / therapeutic use. Bone Marrow Neoplasms. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Remission Induction. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 16847665.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anthracyclines; 0 / Antineoplastic Agents
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23. Kahl B, Yang D: Marginal zone lymphomas: management of nodal, splenic, and MALT NHL. Hematology Am Soc Hematol Educ Program; 2008;:359-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Marginal zone lymphomas: management of nodal, splenic, and MALT NHL.
  • Marginal zone lymphomas are indolent B-cell lymphomas that originate from the marginal zone of B-cell follicles.
  • Despite having a common origin in the marginal zone of the B-cell follicle, there are distinct clinical and molecular characteristics of marginal zone lymphomas originating at different anatomic sites.
  • As such, marginal zone-derived lymphomas are currently categorized by the World Health Organization (WHO) into those originating in the spleen (splenic marginal zone lymphoma), extranodal mucosa-associated lymphoid tissue (MALT lymphoma), or lymph node (nodal marginal zone lymphoma).

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  • (PMID = 19074110.001).
  • [ISSN] 1520-4391
  • [Journal-full-title] Hematology. American Society of Hematology. Education Program
  • [ISO-abbreviation] Hematology Am Soc Hematol Educ Program
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Weiler-Sagie M, Bushelev O, Epelbaum R, Dann EJ, Haim N, Avivi I, Ben-Barak A, Ben-Arie Y, Bar-Shalom R, Israel O: (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med; 2010 Jan;51(1):25-30
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  • [Title] (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients.
  • PET/CT with (18)F-FDG is an important noninvasive diagnostic tool for management of patients with lymphoma, and its use may surpass current guideline recommendations.
  • The aim of the present study is to enlarge the growing body of evidence concerning (18)F-FDG avidity of lymphoma to provide a basis for future guidelines.
  • METHODS: The reports from (18)F-FDG PET/CT studies performed in a single center for staging of 1,093 patients with newly diagnosed Hodgkin disease and non-Hodgkin lymphoma between 2001 and 2008 were reviewed for the presence of (18)F-FDG avidity.
  • Of these patients, 766 patients with a histopathologic diagnosis verified according to the World Health Organization classification were included in the final analysis. (18)F-FDG avidity was defined as the presence of at least 1 focus of (18)F-FDG uptake reported as a disease site.
  • RESULTS: At least one (18)F-FDG-avid lymphoma site was reported for 718 patient studies (94%).
  • Forty-eight patients (6%) had lymphoma not avid for (18)F-FDG. (18)F-FDG avidity was found in all patients (100%) with Hodgkin disease (n = 233), Burkitt lymphoma (n = 18), mantle cell lymphoma (n = 14), nodal marginal zone lymphoma (n = 8), and lymphoblastic lymphoma (n = 6).
  • An (18)F-FDG avidity of 97% was found in patients with diffuse large B-cell lymphoma (216/222), 95% for follicular lymphoma (133/140), 85% for T-cell lymphoma (34/40), 83% for small lymphocytic lymphoma (24/29), and 55% for extranodal marginal zone lymphoma (29/53).
  • CONCLUSION: The present study indicated that with the exception of extranodal marginal zone lymphoma and small lymphocytic lymphoma, most lymphoma subtypes have high (18)F-FDG avidity.
  • The cumulating evidence consistently showing high (18)F-FDG avidity in the potentially curable Burkitt, natural killer/T-cell, and anaplastic large T-cell lymphoma subtypes justifies further investigations of the utility of (18)F-FDG PET in these diseases at presentation.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Lymphoma / metabolism. Lymphoma / radionuclide imaging. Radiopharmaceuticals / pharmacokinetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Young Adult

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  • (PMID = 20009002.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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25. Kojima M, Nakamura S, Murase T, Motoori T, Murayama K, Iijima M, Itoh H, Sakata N, Masawa N: Follicular colonization of nodal marginal-zone B-cell lymphoma resembling follicular lymphoma: report of 6 cases. Int J Surg Pathol; 2005 Jan;13(1):73-8
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  • [Title] Follicular colonization of nodal marginal-zone B-cell lymphoma resembling follicular lymphoma: report of 6 cases.
  • The formation of neoplastic B-cell follicles is accepted as a diagnostic criterion of follicular lymphoma.
  • However, extranodal marginal-zone B-cell lymphomas (MZBLs) of mucosa-associated lymphoid tissue (MALT) type also sometimes contain numerous lymphoid follicles and may even have a predominantly follicular growth pattern.
  • However, morphologic, immunohistochemical, and genotypic findings suggest that lymphoid follicles in extranodal MZBLs are neoplastic follicles formed as the result of colonization of previously reactive follicles by tumor cells (centrocyte-like cells).
  • We present here 6 cases of nodal MZBL demonstrating a follicular growth pattern.
  • CD21/CD23 immunostain demonstrated a disrupted follicular dendritic cell pattern characteristic of follicular colonization in extranodal MZBL of MALT type.
  • Taken in conjunction with the morphologic findings, nodal MZBL may also show a follicular growth pattern similar to extranodal MZBL of MALT type.
  • The marginal-zone nature is most recognizable on immunohistochemistry, although the histologic appearance alone may cause some diagnostic problems.
  • [MeSH-major] Lymph Nodes / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, Follicular / diagnosis
  • [MeSH-minor] Adult. Aged. Antigens, CD / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged

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  • (PMID = 15735858.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor
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26. Kojima M, Nakamura S, Iijima M, Murayama K, Sakata N, Masawa N: Lymphoid variant of hyaline vascular Castleman's disease containing numerous mantle zone lymphocytes with clear cytoplasm. APMIS; 2005 Jan;113(1):75-80
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  • [Title] Lymphoid variant of hyaline vascular Castleman's disease containing numerous mantle zone lymphocytes with clear cytoplasm.
  • We report two unusual cases of hyaline vascular type Castleman's disease showing a pale clear cuff of mantle zone lymphocytes presenting a marginal zone distribution pattern.
  • The histopathologic findings in our cases were similar to those of nodal marginal zone B-cell lymphoma.
  • However, immunohistochemistry demonstrated that both the mantle zone lymphocytes and the pale cuff of the lymphoid cells were CD20+, CD79a+, sIgM+, sIgD+, CD5-, CD10-, CD43-, CD45RO-, Bcl-2+, Bcl-6- and cyclin D1-.
  • Reactive lymph node lesions only rarely show mantle cell hyperplasia with clear cytoplasm.
  • This unusual mantle cell hyperplasia with clear cytoplasm associated with a hyaline vascular type of Castleman's disease should be differentiated from nodal marginal zone B-cell lymphoma, mantle cell lymphoma and follicular lymphoma.
  • To avoid overdiagnosis and overtreatment, it is suggested that immunophenotypic and genotypic studies might be required, and furthermore careful attention should be paid to the morphologic examination.
  • [MeSH-major] Giant Lymph Node Hyperplasia / physiopathology. Mediastinal Neoplasms / physiopathology

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  • (PMID = 15676019.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD57
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27. Anagnostopoulos I, Hummel M, Falini B, Joehrens K, Stein H: Epstein-barr virus infection of monocytoid B-cell proliferates: an early feature of primary viral infection? Am J Surg Pathol; 2005 May;29(5):595-601
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  • [Title] Epstein-barr virus infection of monocytoid B-cell proliferates: an early feature of primary viral infection?
  • Monocytoid cells are a subset of B lymphocytes with characteristic morphology and immunophenotype, which proliferate in a broad variety of reactive lymph node conditions.
  • We found in a series of lymph node specimens from 13 patients having in common a prominent monocytoid B (MCB)-cell reaction in the absence of epithelioid cells or necrosis evidence that Epstein-Barr virus (EBV) can infect MCB cells.
  • Our findings imply that an EBV infection of MCB cells associated with predominant EBNA-2 expression represents an early sign of primary infection and that it should be included in the differential diagnosis of activated lymph nodes with prominent MCB-cell reaction in the absence of epithelioid cells.
  • [MeSH-minor] Adolescent. Adult. Cell Proliferation. DNA-Binding Proteins / analysis. Diagnosis, Differential. Epstein-Barr Virus Nuclear Antigens / analysis. Epstein-Barr Virus Nuclear Antigens / genetics. Female. Humans. In Situ Hybridization. Lymph Nodes / chemistry. Lymph Nodes / pathology. Lymph Nodes / virology. Lymphatic Diseases / diagnosis. Lymphatic Diseases / etiology. Lymphoma / diagnosis. Male. Middle Aged. RNA, Viral / analysis. RNA, Viral / genetics. Trans-Activators / analysis. Viral Matrix Proteins / analysis. Viral Proteins / analysis

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  • (PMID = 15832082.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BZLF1 protein, Herpesvirus 4, Human; 0 / DNA-Binding Proteins; 0 / EBNA-2 protein, Human herpesvirus 4; 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Epstein-Barr Virus Nuclear Antigens; 0 / Epstein-Barr virus encoded RNA 1; 0 / RNA, Viral; 0 / Trans-Activators; 0 / Viral Matrix Proteins; 0 / Viral Proteins
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28. Kim WS, Honma K, Karnan S, Tagawa H, Kim YD, Oh YL, Seto M, Ko YH: Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma. Genes Chromosomes Cancer; 2007 Aug;46(8):776-83
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  • [Title] Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma.
  • The genetic changes in marginal zone B cell lymphomas (MZBCL) vary according to the anatomical region.
  • The study population comprised 24 cases of primary ocular MZBCL, 11 pulmonary MZBCL, and seven nodal MZBCL.
  • FISH analysis for MALT1 gene alteration was performed for ocular and nodal MZBCL and RT-PCR for the detection of API2-MALT1 transcripts was performed for pulmonary MZBCL.
  • Nodal MZBCL showed neither recurrent genome alterations nor any change in MALT1 gene copy number.
  • In conclusion, the array CGH profile of ocular MZBCL is distinct from those of pulmonary and nodal MZBCL.
  • [MeSH-major] Eye Neoplasms / genetics. Genome, Human. Lymphoma, B-Cell, Marginal Zone / genetics. Nucleic Acid Hybridization
  • [MeSH-minor] Chromosome Aberrations. Chromosomes, Artificial, P1 Bacteriophage. Humans. Lung Neoplasms / genetics. Lymph Nodes / pathology. Oncogene Proteins, Fusion / genetics

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  • (PMID = 17492759.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / API2-MALT1 fusion protein, human; 0 / Oncogene Proteins, Fusion
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29. Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y, Itoh H, Motoori T, Masawa N, Nakamura S: Histological variety of floral variant of follicular lymphoma. APMIS; 2006 Sep;114(9):626-32
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  • [Title] Histological variety of floral variant of follicular lymphoma.
  • To further clarify the histopathological findings of the floral variant of follicular lymphoma (FVFL), we studied 13 Japanese cases.
  • Two histological subtypes of neoplastic follicles of FVFL have been described: (i) A macrogerminal center pattern where the mantle zone lymphocytes were invaginated into the neoplastic germinal center, often reminiscent of a floral design. (ii) A microgerminal center pattern where the massive invasion of mantle zone lymphocytes resulted in almost complete breakage of the neoplastic follicles.
  • Moreover, occasional tumor cells showed a lymphocytic and/or histiocytic Reed-Sternberg cell (L&H cells)-like morphology.
  • Three lesions (23%) had a marginal zone component.
  • The overall histological findings of the macrogerminal center are similar to those of florid progressive transformation of germinal center (PTGC), whilst the microgerminal center pattern is similar to that of nodular lymphocyte-predominant Hodgkin lymphoma.
  • Initially, the differential diagnosis between FVFL and florid PTGC was emphasized.
  • However, the present study indicates that nodal marginal zone B-cell lymphoma possessing floral follicles and nodular lymphocyte-predominant Hodgkin lymphoma should be added to the differential diagnosis of FVFL.
  • The germinal center B-cell nature of FVFL is most clearly recognizable by immunohistochemistry, though histological appearance alone may cause some diagnostic problems.
  • [MeSH-major] Lymph Nodes / pathology. Lymphoma, Follicular / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / analysis. Diagnosis, Differential. Female. Germinal Center / pathology. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / isolation & purification. Hodgkin Disease / pathology. Humans. In Situ Hybridization. Male. Middle Aged. Oligonucleotides. RNA, Viral / analysis

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  • (PMID = 16948815.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Oligonucleotides; 0 / RNA, Viral
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30. Pamuk GE, Demir M, Orüm H, Turgut B, Ozyilmaz F, Tekgündüz E: Secondary amyloidosis causing nephrotic syndrome in a patient with non-Hodgkin's lymphoma: quite a rare diagnosis. Clin Lab Haematol; 2006 Aug;28(4):259-61
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  • [Title] Secondary amyloidosis causing nephrotic syndrome in a patient with non-Hodgkin's lymphoma: quite a rare diagnosis.
  • Amyloidosis cases during the course of non-Hodgkin's lymphoma (NHL) are usually of AL-type, only one NHL patient with secondary amyloidosis has been reported.
  • Our 79-year-old male patient visited us with multiple lymphadenopathies, and he was diagnosed with nodal marginal zone B-cell lymphoma.
  • The patient has been under hemodialysis for 10 months and his lymphoma is still in partial remission.
  • [MeSH-major] Amyloidosis / etiology. Lymphoma, B-Cell / complications. Nephrotic Syndrome / etiology

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  • (PMID = 16898966.001).
  • [ISSN] 0141-9854
  • [Journal-full-title] Clinical and laboratory haematology
  • [ISO-abbreviation] Clin Lab Haematol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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31. Prochorec-Sobieszek M, Wagner T: [Lymphoproliferative disorders in Sjögren's syndrome]. Otolaryngol Pol; 2005;59(4):559-64
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  • B-cell lymphoproliferation is a characteristic feature of this syndrome and the lesion may range from benign to malignant.
  • RESULTS: Patients with Sjögren's syndrome [SS] have over 40-fold increased risk of the development B-cell non-Hodgkin's lymphoma.
  • Most cases of lymphomas complicating the course of SS arise in mucosal extranodal sites, especially in the salivary gland, and are classified as low grade marginal zone B-cell lymphoma with long-term survival.
  • The main problem in salivary lymphoproliferation in Sjögren's syndrome consists in the difficulties in the differential diagnosis of lymphoma.
  • Genotypic studies have documented the rearrangement of immunoglobulin genes across the full spectrum of lymphoid infiltrates in the salivary gland including cases regarded as reactive lymphoepithelial sialadenitis [LESA], borderline cases with halos of monocytoid cells surrounding epimyoepithelial islets, and cases with fully developed marginal zone lymphoma [MZL].
  • Thus, the simple detection of B-cell clonality cannot be used as a criterion for the diagnosis of B-cell malignancy.
  • Broad strands of monocytoid B-cells that surround and invade epimyoepithelial islets and monotypic immunoglobulin expression detected by immunohistochemistry are an essential feature for the histopathological diagnosis of MZL.
  • The pathophysiology of lymphoma in SS remains still unknown.
  • Viral infection, hyperstimulation of B cells, disregulation in the process of apoptosis, and unknown oncogenes are suspected to initiate the start of lymphoma.
  • The main clinical features associated with the development of lymphoma in SS include persistent major salivary gland enlargement (> 2 months), persistent lymphadenopathy or splenomegaly, monoclonal gammapathy and type II mixed cryoglobulinemia.
  • The treatment and prognosis of lymphoma associated with SS depend on the type and stage of lymphoma.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / etiology. Salivary Gland Neoplasms / etiology. Sjogren's Syndrome / complications
  • [MeSH-minor] Antigens, CD20 / metabolism. Diagnosis, Differential. Genotype. Humans. Immunohistochemistry. Sialadenitis / complications. Sialadenitis / etiology

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  • (PMID = 16273862.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD20
  • [Number-of-references] 25
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32. Dono M, Ferrarini M: Immunoglobulin gene mutation patterns and heterogeneity of marginal zone lymphoma. Methods Mol Med; 2005;115:173-96
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  • [Title] Immunoglobulin gene mutation patterns and heterogeneity of marginal zone lymphoma.
  • Marginal zone (MZ) or MZ-like B-cells "home" outside the follicles of peripheral lymphoid tissues.
  • Prototypic examples of these B-cells are those that home the MZ of the spleen, although B-cells with similar phenotypic and functional features can be found in the subepithelial (SE) areas of tonsil, in the Peyer's patches, in the lymph nodes, and in the thymic medulla.
  • Beside the so-called extranodal B-cell MALT lymphoma, the splenic MZ lymphoma with or without circulating villous lymphocytes and monocytoid lymphoma also are thought to originate from MZ B-cells.
  • Normal MZ-like B-cells can be isolated from different tissue sources (tonsil, spleen) by using combination Percoll gradients, magnetic fractionation, and fluorescence-activated cell sorting.
  • In this chapter, we review the main procedures used to isolate and test the phenotypic and functional features of the MZ B-cells from human tonsil and spleen in our laboratory and discuss their characteristics by comparing them with the MZ B-cell-derived lymphomas.
  • [MeSH-major] DNA Mutational Analysis / methods. Genes, Immunoglobulin / genetics. Genetic Variation. Lymphoma, B-Cell, Marginal Zone / genetics. Mutation / genetics
  • [MeSH-minor] B-Lymphocytes / physiology. Humans. Immunoglobulin Heavy Chains / genetics. Immunoglobulin Variable Region / genetics. Phenotype. Prognosis. RNA, Neoplasm / analysis. Stomach / physiology

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  • (PMID = 15998968.001).
  • [ISSN] 1543-1894
  • [Journal-full-title] Methods in molecular medicine
  • [ISO-abbreviation] Methods Mol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains; 0 / Immunoglobulin Variable Region; 0 / RNA, Neoplasm
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33. Kojima M, Kitamoto Y, Shimizu K, Matsuda H, Masawa N: Tonsillar lesions of infectious mononucleosis resembling MALT type lymphoma. A report of two cases. Pathol Oncol Res; 2008 Dec;14(4):489-92
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  • [Title] Tonsillar lesions of infectious mononucleosis resembling MALT type lymphoma. A report of two cases.
  • Infectious mononucleosis (IM) is an acute lymphoproliferative disorder that typically occurs in young patients and is usually caused by Epstein-Barr virus.
  • We report here, two cases of tonsillar lesion of IM resembling marginal zone B-cell lymphoma mucosa-associated lymphoid tissue (MALT) type.
  • Histologically, in one case, the tonsil showed diffuse proliferation of medium-sized lymphocytes.
  • The medium-sized lymphocytes had round or slightly indented nuclei with a small solitary nucleoli and abundant clear cytoplasm and somewhat resembled monocytoid B-cells.
  • In the remaining one case, the lymphoid follicles had hyperplastic germinal centers with ill-defined borders surrounded by a sheet-like proliferation of polymorphous infiltration showing a marginal zone distribution pattern.
  • On high-power field, the interfollicular area was diffusely infiltrated by a polymorphous infiltrate of medium-sized lymphocytes with angulated nuclei somewhat resembling centrocyte-like cells, immunoblasts, plasma cells, plasmacytoid cells and histiocytes with or without epithelioid cell feature.
  • Although MALT type lymphoma rarely affected young adults, notably, a number of cases have been reported in the tonsil.
  • The present two cases indicated that acute IM should be added to the differential diagnosis for MALT type lymphoma in young adults.
  • [MeSH-major] Infectious Mononucleosis / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Palatine Tonsil / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, CD / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. In Situ Hybridization. Male. Polymerase Chain Reaction

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  • (PMID = 18592404.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD
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34. El-Hawary AK: Histopathological assessment and immunohistochemical study of nasopharyngeal low grade MALT lymphoma. J Egypt Natl Canc Inst; 2006 Jun;18(2):103-8

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  • [Title] Histopathological assessment and immunohistochemical study of nasopharyngeal low grade MALT lymphoma.
  • INTRODUCTION: MALT lymphoma arises in a variety of body tissues, but most often in the stomach.
  • Though relatively rare, these MALT lymphomas may arise within several sites in the head and neck, and often present diagnostic and therapeutic challenges.
  • Immunohistochemical analysis are helpful in confirming the diagnosis between the MALT-lymphoma and the reactive lymphoid hyperplasia.
  • MALT-type lymphoma demonstrated characteristic negative staining for CD3, CD5 and CD43, positive staining for CD20, and monotypic staining for either kappa or lambda light chain immunoglobulin markers, whereas reactive lymphoid hyperplasia all expressed B and T cell markers.
  • 31 cases were corresponded histomorphologically to low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type and 10 patients with reactive lymphoid hyperplasia of the adenoid.
  • Hematoxylin- eosin-stained slides were reviewed to confirm the diagnosis.
  • RESULTS: All cases of low grade MALT lymphoma show lymphoepithelial lesion and proliferation of centrocyte like cells.
  • Monocytoid B-cells were seen in 12 cases (38.7%).
  • All cases with MALT-type lymphoma expressed CD20 and not CD3 whereas 10 cases of adenoid, all expressed B and T cell markers.
  • Immunohistochemical staining showed that 31 cases of low grade MALT lymphoma were positive for immunoglobin light chain (kappa or lambda) while 10 cases of adenoid were positive for both kappa and lambda light chain.
  • CONCLUSION: Immunohistochemical analysis are helpful in confirming the diagnosis between the MALT-lymphoma and the reactive lymphoid hyperplasia of the nasopharynx.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / diagnosis. Nasopharyngeal Neoplasms / diagnosis

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  • (PMID = 17496934.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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35. Farris AB 3rd, Mark EJ, Kradin RL: Pulmonary "inflammatory myofibroblastic" tumors: a critical examination of the diagnostic category based on quantitative immunohistochemical analysis. Virchows Arch; 2007 May;450(5):585-90
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  • The cases were stained with antibodies to smooth muscle actin (SMA), Factor XIIIa, CD3, CD20, CD68, S-100, anaplastic lymphoma kinase (ALK-1), and human herpevirus-8 (HHV-8).
  • All cases showed substantial numbers of CD68+, Factor XIIIa+, and S-100+ monocytoid cells.
  • Instead, the results suggest that these lesions are composed predominantly of cells of macrophage-dendritic cell lineage.
  • [MeSH-major] Antigens, CD / metabolism. Biomarkers / metabolism. Factor XIIIa / metabolism. Immunohistochemistry / methods. Plasma Cell Granuloma, Pulmonary / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Count. Child. Dendritic Cells / metabolism. Dendritic Cells / pathology. Diagnosis, Differential. Female. Fibroblasts / metabolism. Fibroblasts / pathology. Humans. Macrophages / metabolism. Macrophages / pathology. Male. Middle Aged. Terminology as Topic

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  • (PMID = 17372757.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers; EC 2.3.2.13 / Factor XIIIa
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36. Zhu H, Zhou XG: [Morphologic diversity of plasma cell neoplasms]. Zhonghua Bing Li Xue Za Zhi; 2010 Aug;39(8):528-31
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  • [Title] [Morphologic diversity of plasma cell neoplasms].
  • OBJECTIVE: To investigate the architectural and cytological variations of plasma cell neoplasms, and discuss the diagnosis and differential diagnosis.
  • METHODS: Histological and immunohistochemical examinations were used to study the morphologic and immunophenotypic features of 46 cases of plasma cell neoplasms.
  • RESULTS: 40 out of 46 cases were diffuse growth pattern.
  • Lastly, tumor cells can be polymorphous which composed of multilobated, monocytoid or multinucleated cells in one case.
  • CONCLUSIONS: Except for the common architecture and cytology in plasma cell tumor, unusual morphology may appear.
  • Thus, pay attention to distinguish from lymphoma such as small lymphocytic lymphoma and anaplastic large cell lymphoma, pooly differentiated carcinoma, clear cell carcinoma or Signet-ring cell carcinoma, sarcoma, etc.
  • [MeSH-major] Bone Neoplasms / pathology. Mouth Neoplasms / pathology. Neoplasms, Plasma Cell / pathology. Nose Neoplasms / pathology. Plasmacytoma / pathology

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  • (PMID = 21055031.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD79; 0 / CD79A protein, human; 0 / Immunoglobulin kappa-Chains; 0 / Immunoglobulin lambda-Chains; 0 / Interferon Regulatory Factors; 0 / interferon regulatory factor-4; EC 3.2.2.5 / Antigens, CD38
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37. Krasić D, Radović P, Burić N, Cosić A, Katić V: [MALT lymphoma of the parotid salivary gland]. Vojnosanit Pregl; 2007 Jan;64(1):53-7

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  • [Title] [MALT lymphoma of the parotid salivary gland].
  • BACKGROUND: Mucosa-associated lymphoid tissue (MALT) lymphoma was described for the first time in 1983 by Isaacson and Wright.
  • It was classified into extranodal non-Hodkin's lymphomas of B-cell lymphocytes of the marginal zone of reactive lymphe follicles.
  • It is characterized by both hyperplasia and colonization of plasmocytic, centrocytoid and monocytoid cells, by the infiltration of interfollicular and parafollicular parts of interstitium, as well as by the invasion of clusters of neoplastic lymphoid cells of the glandular epithelium, forming the pathognomic lymphoepithelial MALT limphoma lesions.
  • CASE REPORT: In this paper we presented the two female patients, 59 and 75 years of age, with MALT lymphomas, associated with Miculicz's and Sjögren's syndromes.
  • The paraffine sections were stained by routine histochemical and an immunohistochemical method by using monoclonal antibodies for both B-cell and T-cell lymphomas, due to the verification of lymphoepithelial lesions.
  • The MALT lymphoma diagnosis was based on the histological criteria and confirmed by an immunohistochemical method.
  • After the surgical therapy accompanied by chemotherapy, the patients were controlled at regular intervals, and residual MALT lymphoma did not appear.
  • CONCLUSION: MALT lymphoma is a rare tumor of the salivary glands, with the most frequent localization in the parotide gland.
  • The diagnosis was made pathohistologically and confirmed immunohistochemically.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone. Parotid Neoplasms

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  • (PMID = 17304725.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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38. Schreuder MI, Hoefnagel JJ, Jansen PM, van Krieken JH, Willemze R, Hebeda KM: FISH analysis of MALT lymphoma-specific translocations and aneuploidy in primary cutaneous marginal zone lymphoma. J Pathol; 2005 Feb;205(3):302-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FISH analysis of MALT lymphoma-specific translocations and aneuploidy in primary cutaneous marginal zone lymphoma.
  • Primary cutaneous marginal zone lymphomas (PCMZL) share histological and clinical characteristics with mucosa-associated lymphoid tissue (MALT) lymphomas suggesting a common pathogenesis.
  • A number of recurrent structural and numerical chromosomal aberrations have been described in MALT lymphoma, but their incidence in PCMZL is largely unknown, as is their relation with clinical and pathological data.
  • All three had partly monocytoid histological appearances and lacked blastic transformation.
  • Trisomy 18 was present in two lymphomas without monocytoid morphology.
  • These results indicate that a subgroup of PCMZL with partly monocytoid morphology is genetically related to MZL at other extranodal sites.
  • [MeSH-major] Lymphoma, B-Cell / genetics. Skin Neoplasms / genetics. Translocation, Genetic. Trisomy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Caspases. Chromosomes, Human, Pair 14 / genetics. Chromosomes, Human, Pair 18 / genetics. Female. Follow-Up Studies. Humans. In Situ Hybridization, Fluorescence. Lymphoma, B-Cell, Marginal Zone / genetics. Male. Middle Aged. Neoplasm Proteins / genetics. Prognosis

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  • (PMID = 15682432.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 3.4.22.- / Caspases; EC 3.4.22.- / MALT1 protein, human
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39. Li BZ, Zhou XY, Ye HT, Yang WT, Fan YZ, Lu HF, Shi DR: [Abnormal expression of bcl-10 protein in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue lymphoma type]. Zhonghua Bing Li Xue Za Zhi; 2007 Dec;36(12):819-24

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  • [Title] [Abnormal expression of bcl-10 protein in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue lymphoma type].
  • OBJECTIVE: To evaluate the diagnostic role of nuclear expression of bcl-10 protein in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type.
  • METHODS: One hundred and forty cases of MALT lymphoma were collected from Cancer Hospital of Fudan University (including 38 cases from stomach, 35 cases from ocular adnexa, 16 cases from intestine, 15 cases from skin, 15 cases from salivary gland, 14 cases from lung, 3 cases from thyroid and 4 cases from other sites).
  • Ten cases of reactive follicular hyperplasia of tonsil, 5 cases of reactive lymphoid hyperplasia of orbit and 143 cases of non-Hodgkin's lymphoma other than MALT lymphoma (including 20 cases of NK/T cell lymphoma, 20 cases of follicular lymphomas, 20 cases of anaplastic large cell lymphomas, 20 cases of nodal diffuse large cell B-cell lymphoma (DLBCL), 10 cases of gastric diffuse large B-cell lymphoma, 13 cases of nodal marginal zone B-cell lymphoma, 12 cases of mantle cell lymphoma, 11 cases of splenic marginal zone B-cell lymphoma, 6 cases of angioimmunoblastic T-cell lymphoma, 6 cases of peripheral T-cell lymphoma, not otherwise specified, 3 cases of small lymphocytic lymphoma, 1 case of lymphoplasmacytic lymphoma and 1 case of plasmacytoma were used as controls.
  • RESULTS: In reactive follicular hyperplasia of tonsil, bcl-10 was moderately or strongly expressed in the cytoplasm of germinal center B cells, while the mantle cells were negative and the marginal zone cells and paracortical T cells showed weak staining.
  • As for non-MALT lymphomas, 3 gastric DLBCL showed nuclear expression.
  • In some cases of lymphoma, bcl-10 was expressed in tumor cells but not in reactive lymphoid cells.
  • On the other hand, 92.1% (129/140) of MALT lymphoma were bcl-10 positive.
  • The staining was most intense in MALT lymphoma of ocular adnexa.
  • Cytoplasmic expression of bcl-10 is seen in many different kinds of non-Hodgkin's lymphoma and reactive lymphoid conditions.
  • In some cases of lymphoma, bcl-10 is expressed in tumor cells but not in reactive lymphoid cells, suggesting a possible role of abnormal bcl-10 expression in tumorgenesis.
  • Nuclear expression of bcl-10 is seen mainly in MALT lymphoma, especially when occurring in ocular adnexa and lung.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Gene Expression Regulation, Neoplastic. Lymphoma, B-Cell, Marginal Zone / genetics. Lymphoma, B-Cell, Marginal Zone / pathology
  • [MeSH-minor] Antigens, CD20 / immunology. Cell Nucleus / genetics. Cytoplasm / genetics. Humans. Lymphocytes / pathology. Palatine Tonsil / pathology. Pseudolymphoma / genetics

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  • (PMID = 18346354.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antigens, CD20; 0 / BCL10 protein, human
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40. Honma K, Tsuzuki S, Nakagawa M, Karnan S, Aizawa Y, Kim WS, Kim YD, Ko YH, Seto M: TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma. Genes Chromosomes Cancer; 2008 Jan;47(1):1-7
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  • [Title] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma.
  • The genomic aberrations in extra nodal marginal zone B cell lymphoma vary according to their anatomical origin.
  • This polarization is a reflection of the participation of different genes in the lymphomagenesis of marginal zone B cell lymphoma.
  • We previously demonstrated by means of genome-wide array comparative genomic hybridization (CGH) that the genomic profile of ocular adnexal marginal zone B cell lymphoma is distinct from that of pulmonary or nodal marginal zone B cell lymphoma.
  • The novel finding was a recurrent deletion of a 2.9-Mb region at chromosome band 6q23.3-q24.1, including homozygous loss, in ocular adnexal marginal zone B cell lymphoma.
  • Correlation between genomic loss and expression level was found only for TNFAIP3, demonstrating that TNFAIP3 is a target gene of 6q deletion in ocular adnexal marginal zone B cell lymphoma.
  • TNFAIP3 is an inhibitor of NF-kB signaling so that loss of this gene may play an important role in lymphomagenesis and suggests that TNFAIP3 may act as a tumor suppressor gene in ocular adnexal marginal zone B cell lymphoma.
  • [MeSH-major] Chromosomes, Human, Pair 6 / genetics. Eye Neoplasms / genetics. Gene Deletion. Intracellular Signaling Peptides and Proteins / genetics. Lymphoma, B-Cell, Marginal Zone / genetics. Nuclear Proteins / genetics

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  • (PMID = 17886247.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Nuclear Proteins; EC 6.3.2.19 / TNFAIP3 protein, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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41. Cho-Vega JH, Vega F, Rassidakis G, Medeiros LJ: Primary cutaneous marginal zone B-cell lymphoma. Am J Clin Pathol; 2006 Jun;125 Suppl:S38-49
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  • [Title] Primary cutaneous marginal zone B-cell lymphoma.
  • Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is included as one of the major types of primary cutaneous B-cell lymphoma in the revised World Health Organization-European Organization for Research and Treatment of Cancer classification.
  • PCMZL is composed of a polymorphous infiltrate that includes centrocyte-like, monocytoid, and lymphoplasmacytoid lymphocytes and plasma cells.
  • Numerous reactive T cells and lymphoid follicles are commonly associated with the neoplasm.
  • The neoplastic cells express B-cell markers and usually bcl-2 and are negative for CD5, CD10, and bcl-6.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Skin Neoplasms / pathology

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  • (PMID = 16830956.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 87
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42. Mansoor A, Akbari M, Auer I, Lai R: Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: a morphological variant of mantle cell lymphoma. Hum Pathol; 2007 May;38(5):797-802
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  • [Title] Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: a morphological variant of mantle cell lymphoma.
  • We describe 3 unusual B-cell non-Hodgkin's lymphomas in which the entire tumors histologically mimicked marginal zone B-cell lymphoma.
  • Excisional biopsy from lymph node (2 of 3) and parotid gland (1 of 3) showed proliferation of monocytoid B-cells with plasmacytoid features (2 of 3) and conspicuous absence of large lymphoma cells (3 of 3).
  • Based on these features, we believed that the best classification for these lesions is the marginal zone B-cell lymphoma-like mantle cell lymphoma.
  • [MeSH-major] Cyclin D1 / metabolism. Lymphoma, B-Cell / genetics. Lymphoma, B-Cell / metabolism. Lymphoma, Mantle-Cell / genetics. Lymphoma, Mantle-Cell / microbiology. Translocation, Genetic
  • [MeSH-minor] Adult. Aged. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 14. Humans. Immunohistochemistry. Immunophenotyping. Lymph Nodes / pathology. Male. Middle Aged

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  • (PMID = 17316759.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 136601-57-5 / Cyclin D1
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43. Akyurek N, Ren Y, Rassidakis GZ, Schlette EJ, Medeiros LJ: Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas. Cancer; 2006 Oct 15;107(8):1844-51
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  • [Title] Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas.
  • METHODS: cIAP1, cIAP2, and XIAP were assessed in lymphoma cell lines, 240 B-cell non-Hodgkin lymphoma (NHL) tumors, and 40 Hodgkin lymphoma (HL) tumors.
  • RESULTS: All IAPs were expressed in most NHL and all HL cell lines.
  • cIAP1 was positive in all precursor B-cell lymphoblastic lymphoma/leukemia (LBL) and nodal marginal zone B-cell lymphoma (MZL), over 90% of follicular lymphoma and diffuse large B-cell lymphoma (DLBCL), and approximately 50% to 60% of myeloma, Burkitt lymphoma (BL), lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM), small lymphocytic lymphoma/ chronic lymphocytic leukemia (SLL/CLL), extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT-lymphoma), splenic MZL, and mantle cell lymphoma. cIAP2 was positive in all MALT-lymphoma, over 90% of precursor B-cell LBL (94%), most BL (75%), LPL/WM (71%), and SLL/CLL (67%), and approximately 40% to 60% of follicular lymphoma, myeloma, and DLBCL.
  • XIAP was positive most cases of precursor B-cell LBL (57%) and approximately 30% to 40% of nodal MZL, BL, and DLBCL.
  • CONCLUSIONS: Differential expression of IAPs in B-cell lymphomas suggests differences in pathogenesis that may have implications for novel treatment strategies targeting IAPs.
  • [MeSH-major] Hodgkin Disease / metabolism. Inhibitor of Apoptosis Proteins / metabolism. Lymphoma, B-Cell / metabolism
  • [MeSH-minor] Blotting, Western. Cell Line, Tumor. Humans. Immunohistochemistry. X-Linked Inhibitor of Apoptosis Protein / metabolism

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  • [Copyright] 2006 American Cancer Society
  • (PMID = 16983704.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inhibitor of Apoptosis Proteins; 0 / X-Linked Inhibitor of Apoptosis Protein; 0 / XIAP protein, human
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44. Jöhrens K, Moos V, Schneider T, Anagnostopoulos I: T-box-expressed-in-T-cells (T-bet) expression by the tumor cells of hairy-cell leukemia correlates with interferon-gamma production. Leuk Lymphoma; 2009 Oct;50(10):1687-92
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  • [Title] T-box-expressed-in-T-cells (T-bet) expression by the tumor cells of hairy-cell leukemia correlates with interferon-gamma production.
  • Hairy cell leukemia (HCL) is an uncommon B-cell malignancy with unknown pathogenesis.
  • T-bet is the master regulator of the T-helper (Th)1 cell response regulating interferon gamma (IFN-gamma) production and also plays a central role in the T-cell independent Th1-like B-cell response.
  • Here, we demonstrate by fluorescence activated cell sorting (FACS) analysis that neoplastic cells from the peripheral blood of five patients with HCL showed an enhanced expression of IFN-gamma after stimulation.
  • Based on our recent findings that a non-neoplastic B-cell subset, the monocytoid B-cells, are T-bet positive and produce IFN-gamma, we propose that monocytoid and hairy B-cells have a similar function and that the T-bet-IFN-gamma axis is involved in the pathogenesis of HCL.
  • [MeSH-major] B-Lymphocyte Subsets / secretion. Cell Transformation, Neoplastic / genetics. Gene Expression Regulation, Leukemic. Interferon-gamma / biosynthesis. Leukemia, Hairy Cell / blood. Neoplasm Proteins / physiology. T-Box Domain Proteins / physiology
  • [MeSH-minor] Antigens, CD / analysis. Antigens, CD19 / analysis. Antigens, Neoplasm / analysis. Cells, Cultured / drug effects. Cells, Cultured / secretion. Cytokines / secretion. Enterotoxins / pharmacology. Humans. Immunophenotyping. Integrin alpha Chains / analysis. Ionomycin / pharmacology. T-Lymphocytes / secretion. Tetradecanoylphorbol Acetate / pharmacology

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  • (PMID = 19757302.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD19; 0 / Antigens, Neoplasm; 0 / Cytokines; 0 / Enterotoxins; 0 / Integrin alpha Chains; 0 / Neoplasm Proteins; 0 / T-Box Domain Proteins; 0 / T-box transcription factor TBX21; 0 / alpha E integrins; 39424-53-8 / enterotoxin B, staphylococcal; 56092-81-0 / Ionomycin; 82115-62-6 / Interferon-gamma; NI40JAQ945 / Tetradecanoylphorbol Acetate
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45. Airaghi L, Greco I, Carrabba M, Barcella M, Baldini IM, Bonara P, Goldaniga M, Baldini L: Unusual presentation of large B cell lymphoma: a case report and review of literature. Clin Lab Haematol; 2006 Oct;28(5):338-42
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  • [Title] Unusual presentation of large B cell lymphoma: a case report and review of literature.
  • Diffuse large B cell lymphoma (DLBCL) is the largest subtype of non-Hodgkin's lymphomas (NHLs) and is characterized by relatively frequent extranodal presentation.
  • Cytofluorimetric analysis of a renal specimen showed medium-to-large lympho-monocytoid elements positive for CD20 with monoclonal expression of immunoglobulin kappa light chain.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Kidney Neoplasms / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Paresthesia / etiology

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  • (PMID = 16999726.001).
  • [ISSN] 0141-9854
  • [Journal-full-title] Clinical and laboratory haematology
  • [ISO-abbreviation] Clin Lab Haematol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 30
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46. Piña-Oviedo S, Ortiz-Hidalgo C: [Historical development and current concepts on B-cell lymphomas of the marginal extraganglionar site of lymphoid tissue associated with MALT lymphoma. A tribute to Dennis H Wright and Peter G Isaacson]. Gac Med Mex; 2007 May-Jun;143(3):237-44
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  • [Title] [Historical development and current concepts on B-cell lymphomas of the marginal extraganglionar site of lymphoid tissue associated with MALT lymphoma. A tribute to Dennis H Wright and Peter G Isaacson].
  • [Transliterated title] Linfoma de céllulas B de la zona marginal extraganglionar del tejido linfoide asociado a mucosas (linfoma MALT). Evolución histórica y conceptos actuales. Un tributo a Dennis H. Wright y Peter G. Isaacson.
  • Significant advances in the understanding of marginal zone lymphoma since the first description in 1983 by Peter Isaacson and Dennis Wright have been noted.
  • MALT lymphomas are a subgroup of low-grade B-cell lymphomas that arise from extranodal sites, comprising 7-8% of all B-cell lymphomas and displaying distinct clinicopathological characteristics.
  • MALT lymphomas remain localized in the primary site for long periods of time and seldom disseminate unto other organs.
  • These type of lymphomas infrequently arise in native MALT, but instead arise in MALT acquired in the course of chronic inflammatory disorders, such as Sjögren's syndrome and Helicobacter pylori infection.
  • Eradication of H. pylori produces a clinical regression of the lymphoma in about 75% of cases.
  • The histological hallmarks of MALT lymphoma include neoplastic centrocyte-like B cells, cells resembling monocytoid cells and the presence of lymphoepithelial lesions.
  • The gastrointestinal tract, particularly the stomach, include two-thirds of cases; however MALT lymphomas also occur in other organs such as salivary glands, lung, thyroid, ocular adnexa, breast and skin.
  • Genetic studies have identified three chromosomal translocations specifically associated with MALT lymphomas that include: t(1l:18)(q21;q21), t(1;14)(p22;q32), and t(14;18)(q32;q21).
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / history

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  • (PMID = 17722452.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Biography; English Abstract; Historical Article; Journal Article; Portraits
  • [Publication-country] Mexico
  • [Personal-name-as-subject] Wright DH; Isaacson PG
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47. Malikhova OA, Poddubnyĭ BK, Poddubnaia IV, Moskalenko OA, Kokosadze NV, Probatova NA, Kovrigina AM: [Clinical and morphological aspects of MALT-gastric lymphoma]. Eksp Klin Gastroenterol; 2010;(6):24-9
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  • [Title] [Clinical and morphological aspects of MALT-gastric lymphoma].
  • THE AIM: The aim of this work was to elaborate clinico-morphological and immunohistochemical criteria of gastric MALT-lymphomas and to differentiate them from another with similar histology.
  • MATERIALS AND METHODS: Between 1983 and 2007, 704 patients with diagnosis of extranodal lymphoma were observed in Russian Cancer Research Center.
  • The work included biopsy and postoperation samples from 115 patients with primary gastric lymphoma, who were observed in Russian Cancer Research Center since 1995.
  • On presented material with primary lymphomas were elaborated morphological criteria of MALT-lymphoma diagnosis for gastrobiopsy, based on histological, immunohistochemical and genetic examination.
  • Also were devised differential diagnostic criteria of MALT-lymphoma.
  • RESULTS: Follow morphological signs were estimated: cell composition, atypia of neoplastic elements, presence of plasmocellular differentiation of lymphoid cells, expression of plasmocytary infiltration, lymphoepithelial lesion and reactive lymphoid follicles with or without colonization, presence of blasts.
  • So, in 35.2% cases part of neoplastic elements had the aspect of monocytoid B-lymphocytes.
  • Lymphoepithelial lesions (LELs) are aggregates from three and more marginal zone cells, destroyed epithelium of glands, were revealed in half of cases.
  • The next important sign is coexpression T-cell marker CD43 on neoplastic B-cells.
  • Cases of MALT-lymphoma with t(11;.
  • CONCLUSION: The most informative morphological, immunohistochemical features were ascertained as in diagnosis, as in differentiation with another neoplasms with similar morphology and reactive lymphoid infiltrates.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Gastric Mucosa / immunology. Gastric Mucosa / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Young Adult

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  • (PMID = 20731161.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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48. Wang G, Auerbach A, Wei M, Dow N, Barry TS, Hodge L, Schaffer D, Sobin LH, Aguilera NS: t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in stomach: a study of 48 cases. Mod Pathol; 2009 Jan;22(1):79-86
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  • [Title] t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in stomach: a study of 48 cases.
  • Gastric extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MZL-MALT) is speculated to be immune mediated and is notable for responding to treatment by Helicobacter pylori eradication.
  • Three distinct morphological subtypes were recognized: monocytoid, small lymphocytic, and plasmacytoid.
  • The 15 t(11;18)(q21;q21) translocation-positive cases had either monocytoid (12 of 15) or small lymphocytic morphology (3 of 15).
  • Our data show that t(11;18)(q21;q21)-positive MZL-MALTs frequently show monocytoid morphology, less often small lymphocytic morphology, and not purely plasmacytoid morphology.
  • Identification of a t(11;18)(q21;q21) by reverse transcription real-time PCR is highly specific for MZL-MALT and helps in the diagnosis of MZL-MALT.
  • [MeSH-major] Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, Pair 18 / genetics. Lymphoma, B-Cell, Marginal Zone / genetics. Stomach Neoplasms / genetics

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  • (PMID = 18820661.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD43
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49. Arcaini L, Paulli M, Burcheri S, Rossi A, Spina M, Passamonti F, Lucioni M, Motta T, Canzonieri V, Montanari M, Bonoldi E, Gallamini A, Uziel L, Crugnola M, Ramponi A, Montanari F, Pascutto C, Morra E, Lazzarino M, Intergruppo Italiano Linfomi: Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease. Br J Haematol; 2007 Jan;136(2):301-4
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  • [Title] Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease.
  • This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma.
  • According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Rare Diseases / pathology

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  • (PMID = 17233821.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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50. Torlakovic EE, Aamot HV, Heim S: A marginal zone phenotype in follicular lymphoma with t(14;18) is associated with secondary cytogenetic aberrations typical of marginal zone lymphoma. J Pathol; 2006 Jun;209(2):258-64
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  • [Title] A marginal zone phenotype in follicular lymphoma with t(14;18) is associated with secondary cytogenetic aberrations typical of marginal zone lymphoma.
  • Marginal zone differentiation of follicular lymphomas (FL), sometimes referred to as monocytoid B-cell differentiation, is a relatively uncommon phenomenon.
  • We have analysed 131 primary nodal FL with t(14;18)(q32;q21) for secondary cytogenetic aberrations previously described as recurrent in marginal zone lymphomas (MZL) to identify their frequency and possible association with morphological evidence of marginal zone differentiation.
  • At least focal morphological evidence of marginal zone differentiation occurred in 35/131 (27%) FL with t(14;18)(q32;q21) as the primary chromosomal abnormality.
  • None of the recurrent balanced translocations characteristic of extranodal MZL were seen secondarily in the nodal FLs with t(14;18)(q32;q21).
  • However, 43/131 (33%) cases had at least one of the above secondary cytogenetic aberrations previously reported as recurrent aberrations in MZL and, when combined, these were significantly more frequent in FL with morphological evidence of marginal zone differentiation (p<0.0001, two-sided Fisher's exact test).
  • Aberrations of chromosome 3 and, in particular, trisomy 3 occurred frequently in FL with marginal zone differentiation (p=0.002 and p<0.0001, respectively, two-sided Fisher's exact test), while chromosome 21, 22, and X chromosome aberrations, which have not been described previously as recurrent in MZL, were also significantly associated with marginal zone differentiation in FL (p=0.002, p=0.037, p=0.039, respectively, two-sided Fisher's exact test).
  • [MeSH-major] Chromosome Aberrations. Lymphoma, Follicular / genetics. Translocation, Genetic / genetics
  • [MeSH-minor] Cell Differentiation / genetics. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 12 / genetics. Chromosomes, Human, Pair 18 / genetics. Chromosomes, Human, Pair 3 / genetics. Chromosomes, Human, Pair 7 / genetics. Cytogenetic Analysis / methods. Humans. Immunophenotyping / methods. Phenotype. Trisomy / genetics

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  • [Copyright] Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 16583359.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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51. Tanaka T, Iino M: t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa. J Cancer Res Clin Oncol; 2010 Nov;136(11):1783-5
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  • [Title] t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa.
  • PURPOSE: The t(11;18)(q21;q21) chromosome translocation is frequent in gastric MALT lymphoma, but the t(11;18)(q21;q21) chromosome translocation is very rare in other sites of MALT lymphomas.
  • We investigated the possibility that MALT lymphoma occurred in the right buccal mucosa of a 66-year-old Japanese woman who had the t(11;18)(q21;q21) chromosome translocation.
  • RESULTS: Some colonized lymphoid follicles with mantle zone were observed on low-power field, and centrocyte-like cells and monocytoid B cells were observed on high-power field.
  • CONCLUSION: We report that MALT lymphoma in buccal mucosa has the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) by using the nested PCR and FISH analysis.
  • This is the first report of the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in the oral cavity.
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 18. Lymphoma, B-Cell, Marginal Zone / genetics. Translocation, Genetic
  • [MeSH-minor] Aged. Caspases / genetics. Female. Gene Fusion. Genes, APC. Humans. Magnetic Resonance Imaging. Mouth Mucosa / pathology. Mouth Neoplasms / genetics. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neoplasm Proteins / genetics. Polymerase Chain Reaction. Tomography, X-Ray Computed. Transcription, Genetic. Treatment Outcome


52. Kawahara K, Sasada S, Nagano T, Suzuki H, Kobayashi M, Matsui K, Takata K, Yoshino T, Michida T, Iwasaki T: Pleural MALT lymphoma diagnosed on thoracoscopic resection under local anesthesia using an insulation-tipped diathermic knife. Pathol Int; 2008 Apr;58(4):253-6
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  • [Title] Pleural MALT lymphoma diagnosed on thoracoscopic resection under local anesthesia using an insulation-tipped diathermic knife.
  • They were composed of centrocyte-like and monocytoid cells.
  • A diagnosis of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) arising in the pleura was therefore made.
  • To the authors' knowledge this is the first case in which IT-knife was used for diagnosis of a pleural lesion.
  • (iii) mesothelial cells not infiltrated by lymphoma cell clusters;.
  • [MeSH-major] Electrocoagulation / instrumentation. Lymphoma, B-Cell, Marginal Zone / diagnosis. Pleural Effusion, Malignant / diagnosis. Pleural Neoplasms / diagnosis. Thoracoscopy. Thoracotomy

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  • (PMID = 18324920.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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53. Saka M, Morioka J, Kajiwara K, Yoshikawa K, Amano T, Kubota H, Nomura S, Kato S, Fujii M, Fujisawa H, Suzuki M: [MALT-type lymphoma of lacrimal gland: case report]. No Shinkei Geka; 2007 May;35(5):475-9
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  • [Title] [MALT-type lymphoma of lacrimal gland: case report].
  • The hematoxilyn-eosin staining of the surgical specimen showed a dense infiltrate of lymphocytes, which were composed predominantly of small lymphocytes, centrocyte-like cells, monocytoid cells, and occasionally transformed lymphocytes.
  • The immunohistochemical findings for CD20, CD3, UCHL-1, CD23, CD5, cyclinD1, and bcl-2 were compatible with Mucosa Associated Lymphoid Tissue (MALT)-type lymphoma.
  • [MeSH-major] Eye Neoplasms / diagnosis. Lacrimal Apparatus. Lymphoma, B-Cell, Marginal Zone / diagnosis

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  • (PMID = 17491343.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] K2I13DR72L / Gadolinium DTPA
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54. Zhang YN, Zheng YY, Zhou XG, Zhang SH, Jin Y, Xie JL, Chen SY, Shi Y, Wu LH: [Clinicopathologic study of splenic marginal zone B-cell lymphoma]. Zhonghua Bing Li Xue Za Zhi; 2009 Apr;38(4):243-7
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  • [Title] [Clinicopathologic study of splenic marginal zone B-cell lymphoma].
  • OBJECTIVE: To study the clinicopathologic features, diagnosis and differential diagnosis of splenic marginal zone B-cell lymphoma (SMZL).
  • Six of them exhibited the classic biphasic appearance with central aggregates of small B cells rimmed by a peripheral zone of atypical monocytoid B cells.
  • The remaining 2 cases had a monomorphous appearance, consisting mainly of atypical monocytoid B cells.
  • The proliferation index, as highlighted by Ki-67 immunostaining, was low (< 15%).
  • CONCLUSIONS: SMZL is an indolent B-cell non-Hodgkin lymphoma.
  • In general, the prognosis of this lymphoma type is good.
  • The lymphoma cells predominantly grow in micronodular pattern, with atypical monocytoid B cells rimming around the small B cells, which aggregates in the center.
  • The differential diagnosis includes other small B-cell lymphomas and lymphoid hyperplasia of spleen.
  • [MeSH-major] Antigens, CD20 / metabolism. Lymphoma, B-Cell, Marginal Zone / pathology. Splenic Neoplasms / pathology

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  • (PMID = 19575895.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2
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55. Imataki O, Ohnishi H, Yamaoka G, Arai T, Kitanaka A, Kubota Y, Kushida Y, Ishida T, Tanaka T: Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse. Int J Clin Oncol; 2010 Feb;15(1):112-5
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  • [Title] Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse.
  • A lineage switch in leukemia, in which the leukemic cell lineage at onset converts to another lineage at a later time, is an uncommon type of hybrid (mixed) leukemia regarded as a variation of bilineage leukemia.
  • We present a case of a 60-year-old female diagnosed with precursor B cell acute lymphoblastic leukemia (ALL), whose markers in flow cytometry shifted from their original status of CD19+, 22+, 79a+, 13+, HLA-DR+, and TdT+.
  • Two weeks after liver biopsy, blast cells progressively appeared in the peripheral blood; these cells had a monocytoid morphology and phenotype (CD13, 14) but were accompanied by myeloid (CD33) and lymphoid (CD2, 4, 20) cells.
  • This phenotypical conversion from B-ALL to hybrid leukemia featuring monocytoid characteristics is known as a lineage switch.
  • [MeSH-major] Leukemia, Biphenotypic, Acute / pathology. Leukemia, Monocytic, Acute / pathology. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • [MeSH-minor] Biomarkers, Tumor / blood. Bone Marrow / pathology. Cell Lineage. Female. Humans. Immunophenotyping. Middle Aged. Recurrence

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  • [Cites] Leukemia. 1995 Dec;9(12):2023-6 [8609712.001]
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  • (PMID = 20066454.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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56. Hentschel N, Krusch M, Kiener PA, Kolb HJ, Salih HR, Schmetzer HM: Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma. Eur J Haematol; 2006 Aug;77(2):91-101
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  • [Title] Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma.
  • Recently, we demonstrated that low levels of soluble (s) CD137L and high levels of sCD178 correlate significantly with a long progression free survival in patients with myelodysplastic syndrome (MDS).
  • In this study, we correlated sCD137L and sCD178 levels in sera of 42 samples of patients with acute myeloid leukemia (AML) and 46 samples of patients with non-Hodgkin's lymphoma (NHL) with stages, subtypes, and the clinical course of the diseases and determined cut-off values with maximum probability for significant differentiation between cases with higher/lower probability for progress free survival.
  • Statistically significant higher median levels of sCD137L are present in patients with undifferentiated AML (M1/M2, 1,470 pg/mL), poor cytogenetic risk (288 pg/mL) and higher levels of BM-blasts (186 pg/mL) compared with patients with monocytoid AML (M4/M5, 89 pg/mL), intermediate cytogenetic risk (59 pg/mL) and lower levels of BM-blasts (14 pg/mL) respectively.
  • [MeSH-major] Biomarkers, Tumor / blood. Leukemia, Myeloid / blood. Lymphoma, Non-Hodgkin / blood. Membrane Glycoproteins / blood. Neoplasm Proteins / blood. Tumor Necrosis Factors / blood
  • [MeSH-minor] 4-1BB Ligand. Acute Disease. Adult. Aged. Aged, 80 and over. Blast Crisis / blood. Child, Preschool. Disease Progression. Disease-Free Survival. Fas Ligand Protein. Female. Humans. Leukemia, Lymphocytic, Chronic, B-Cell / blood. Lymphoma, B-Cell / blood. Lymphoma, T-Cell / blood. Male. Middle Aged. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / blood. Prognosis. Retrospective Studies. Solubility. Survival Analysis

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  • (PMID = 16800841.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / 4-1BB Ligand; 0 / Biomarkers, Tumor; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / TNFSF9 protein, human; 0 / Tumor Necrosis Factors
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57. Golardi N, Velasco MR, Elghetany MT: Marginal zone variant of mantle cell lymphoma: CD5-negative cyclin D1-positive variant posing a diagnostic dilemma. Pathol Int; 2009 May;59(5):317-21
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  • [Title] Marginal zone variant of mantle cell lymphoma: CD5-negative cyclin D1-positive variant posing a diagnostic dilemma.
  • Described herein is an unusual case of mantle cell lymphoma (MCL) histologically mimicking marginal zone lymphoma (MZL).
  • A transbronchial biopsy showed small blue cells suspicious for small cell carcinoma.
  • On further analysis the cells were predominantly small cleaved and CD20 positive, suggesting follicular lymphoma, grade 2.
  • An axillary lymph node biopsy showed germinal centers surrounded by monocytoid B cells.
  • Flow cytometry was negative for CD5 and CD23 and the diagnosis of MZL was considered.
  • Differentiating MCL from MZL has prognostic and therapeutic implications, particularly when considering the potential role of targeted therapy and cell cycle modulators.
  • [MeSH-major] Antigens, CD5 / metabolism. Biomarkers, Tumor / administration & dosage. Cyclin D1 / metabolism. Lung Neoplasms / diagnosis. Lymphoma, Mantle-Cell / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Flow Cytometry. Humans. Immunohistochemistry. Lymph Nodes / metabolism. Lymph Nodes / pathology. Lymphoma, B-Cell, Marginal Zone / diagnosis. Male. Small Cell Lung Carcinoma / diagnosis

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  • (PMID = 19432674.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Biomarkers, Tumor; 136601-57-5 / Cyclin D1
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58. Li BZ, Yu CJ, Xu JJ, Lu HF, Shi DR: [Clinicopathologic characteristics and chromosomal abnormalities in salivary mucosa associated lymphoid tissue lymphomas]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Aug;44(8):651-6
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  • [Title] [Clinicopathologic characteristics and chromosomal abnormalities in salivary mucosa associated lymphoid tissue lymphomas].
  • OBJECTIVE: To study the morphological and genetic characteristics in salivary gland marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) lymphomas.
  • METHODS: Twenty-eight cases of MALT lymphomas of salivary gland were collected from Department of Pathology, Cancer Hospital of Fudan University.
  • Twenty-two (78.6%) showed prominent monocytoid B cells and more often formed broad halos around epithelial islands.
  • Eight to fifteen months after operation, 8 cases found recurred nodules on the original resected sites or cervical lymph nodes, but did not get repeated biopsy.
  • CONCLUSIONS: Most salivary MALT lymphomas are arising from parotid glands.
  • The final diagnosis depends on the pathological findings, the number and distribution of monocytoid B cells and clusters of plasmacytoid cells are hints for diagnosis of salivary MALT lymphomas, invasion of blood vessels or nerve also help for malignant diagnosis. t(11;18) and trisomy 18 may be the main chromosomal abnormalities in salivary gland MALT lymphomas, but with low morbidity.
  • This genetic characteristic may connect with the low malignancy and slow progression in biological behavior.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / genetics. Lymphoma, B-Cell, Marginal Zone / pathology. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 19961773.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Kojima M, Itoh H, Motegi A, Sakata N, Masawa N: Localized lymphoid hyperplasia of the rectum resembling polypoid mucosa-associated lymphoid tissue lymphoma: a report of three cases. Pathol Res Pract; 2005;201(11):757-61
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  • [Title] Localized lymphoid hyperplasia of the rectum resembling polypoid mucosa-associated lymphoid tissue lymphoma: a report of three cases.
  • Histologically, benign lymphoid hyperplasia of the rectum is usually characterized by large lymphoid follicles with active germinal centers and by a narrow surrounding mantle zone and marginal zone (MZ).
  • We report here three cases of benign lymphoid hyperplasia of the rectum associated with prominent marginal zone hyperplasia, which caused serious difficulty in the differential diagnosis from the polypoid type of mucosa-associated lymphoid tissue (MALT) lymphoma.
  • The expanded MZs contained numerous monocytoid B-cells (MBC) and scattered large transformed B-cells.
  • Initially, combined colonoscopic and histological findings strongly supported a diagnosis of polypoid MALT-type lymphoma of the rectum.
  • The present cases indicated that benign lymphoid hyperplasia of the rectum should be included in the differential diagnosis for polypoid MALT-type lymphoma of the rectum.
  • [MeSH-major] Lymphocytes / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Pseudolymphoma / pathology. Rectal Diseases / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Aged. Antigens, CD20 / analysis. Antigens, CD43 / analysis. B-Lymphocytes / chemistry. B-Lymphocytes / metabolism. B-Lymphocytes / pathology. Colonic Polyps / surgery. Diagnosis, Differential. Female. Genotype. Humans. Immunohistochemistry. Immunophenotyping. Middle Aged. Rectum / metabolism. Rectum / pathology. Rectum / surgery

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  • (PMID = 16325519.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD43
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60. Vongchan P, Linhardt RJ: Expression of human liver HSPGs on acute myeloid leukemia. Clin Immunol; 2007 Feb;122(2):194-206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Heparan sulfate proteoglycans (HSPGs) play important biological roles in cell-matrix adhesion processes and are essential regulators of growth actions.
  • Despite HSPGs important biological functions, little is known about its cell-specific distribution patterns.
  • Distribution of HSPG reactive to this mAb was studied in normal blood cells, hematopoietic cell lines and blood cells isolated from patients with various hematologic disorders using indirect immunofluorescence.
  • There was no expression of molecules recognized by this mAb on lymphoid (Daudi, Jurkat, SupT-1) and monocytoid (U937) cell lines.
  • Peripheral blood cells, normal bone marrow, together with leukocytes isolated from patients with acute lymphoblastic leukemia, chronic myelocytic leukemia, Hodgkin's disease or Non-Hodgkin's lymphoma, were also negative.
  • In contrast, 1E4-1C2 showed significant positive results on human myeloid cell lines HL-60 and K562.
  • These results suggest that malignancies of cells in myeloid lineage may cause expression of HSPGs that are detected by this specific mAb, making it a potential co-marker for the diagnosis of acute myeloid leukemia.

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  • (PMID = 17035092.001).
  • [ISSN] 1521-6616
  • [Journal-full-title] Clinical immunology (Orlando, Fla.)
  • [ISO-abbreviation] Clin. Immunol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL052622-09; United States / NHLBI NIH HHS / HL / R01 HL052622; United States / NHLBI NIH HHS / HL / HL052622-09; United States / NIGMS NIH HHS / GM / GM038060-19; United States / NIGMS NIH HHS / GM / R01 GM038060; United States / NIGMS NIH HHS / GM / R01 GM038060-19
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Heparan Sulfate Proteoglycans; 0 / Membrane Glycoproteins
  • [Other-IDs] NLM/ NIHMS75574; NLM/ PMC4142644
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61. Pilarski LM, Pilarski PM, Belch AR: Multiple myeloma may include microvessel endothelial cells of malignant origin. Leuk Lymphoma; 2010 Apr;51(4):592-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple myeloma may include microvessel endothelial cells of malignant origin.
  • Multiple myeloma (MM) comprises B and plasma cell compartments that originate from the same parent B cell and share as a cancer signature the same clonotypic IgH VDJ gene rearrangement.
  • Here, we hypothesize that functional interactions between MM plasma cells (MM-PC) and their sister population of MM monocytoid B cells lead to the generation of microvessel endothelium of malignant origin from the monocytoid B cell progenitors.
  • We predict that MM monocytoid B cells-in response to both paracrine and autocrine pathways-contribute to tumor neovascularization in the bone marrow of MM patients.
  • Our hypothesis further predicts that in MM, endothelial cells of malignant origin coexist with those of normal origin.
  • We speculate that malignant development of MM incorporates functionally distinct sister lineages arising from the same MM progenitor that-by working together-ensure survival of the MM clone.
  • We hypothesize that these two arms of the malignant MM clone are functionally interlinked to promote growth of the MM-PC compartment; by providing its own microenvironment, MM clonal evolution may ensure neovascularization to support an expanding malignancy.
  • [MeSH-minor] B-Lymphocytes / pathology. Cell Lineage / physiology. Concept Formation. Humans. Microvessels / pathology. Models, Biological. Neoplastic Stem Cells / pathology. Plasma Cells / pathology

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  • (PMID = 20233053.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 41
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62. Mikolaenko I, Listinsky CM: Systemic CD5+ MALT lymphoma: presentation with Waldenstrom syndrome. Ann Diagn Pathol; 2009 Aug;13(4):272-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systemic CD5+ MALT lymphoma: presentation with Waldenstrom syndrome.
  • We report a case of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in a 75-year-old woman with a neuropathy related to high levels of serum immunoglobulin M and a history of rheumatoid arthritis and polymyositis.
  • The patient developed a mass in the right submandibular salivary gland, and this mass demonstrated histopathologic features that are typical of MALT lymphoma, including infiltrates of small monocytoid B cells in the epithelium (forming "lymphoepithelial lesions"), a reactive background of florid germinal center hyperplasia, and follicular colonization by the monocytoid B cells.
  • Flow cytometric analysis confirmed the presence of clonal mature B cells; however, unlike most MALT lymphomas, these cells coexpressed dim CD5.
  • Clinical staging revealed evidence of systemic distribution with documented disease involving the bone marrow, the lung, and a paratracheal lymph node.
  • Analysis of this unusual systemic MALT lymphoma, and a comparison with similar examples from the literature, illuminates relationships among MALT lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and Waldenstrom macroglobulinemia.
  • [MeSH-major] Antigens, CD5 / metabolism. Lymphoma, B-Cell, Marginal Zone / diagnosis. Salivary Gland Neoplasms / diagnosis. Waldenstrom Macroglobulinemia / diagnosis
  • [MeSH-minor] Aged. B-Lymphocytes / pathology. Female. Humans. Immunoglobulin M / blood. Peripheral Nervous System Diseases / complications. Peripheral Nervous System Diseases / diagnosis. Peripheral Nervous System Diseases / pathology. Syndrome

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  • (PMID = 19608087.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Immunoglobulin M
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63. Kojima M, Tanaka H, Matsuda H, Iijima M, Motoori T, Masawa N: Floral variant of follicular lymphoma containing marginal zone B-cell component. Report of two cases. APMIS; 2005 Sep;113(9):638-42
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  • [Title] Floral variant of follicular lymphoma containing marginal zone B-cell component. Report of two cases.
  • We here report two unusual cases of floral variant of follicular lymphoma containing marginal zone B-cells.
  • The outer zone of neoplastic follicles was surrounded by a pale cuff of marginal zone B-cells.
  • Immunohistological study demonstrated that both the germinal center and marginal zone component lay within the follicular dendritic cell network.
  • However, a portion of the marginal zone component weakly expressed bcl-2 but not CD10.
  • Nodal marginal zone B-cell lymphoma (NMZBL) occasionally possesses "floral" lymphoid follicles.
  • Follicular lymphoma with marginal zone differentiation is a high-risk variant of follicular lymphoma.
  • In diagnostic practice, the differential diagnosis between the floral variant of follicular lymphoma containing marginal zone B-cells and the "floral variant" of NMZBL is important.
  • [MeSH-major] B-Lymphocytes / immunology. Lymph Nodes / pathology. Lymphoma, Follicular / pathology

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  • (PMID = 16218941.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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64. Bertoni F, Zucca E: State-of-the-art therapeutics: marginal-zone lymphoma. J Clin Oncol; 2005 Sep 10;23(26):6415-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] State-of-the-art therapeutics: marginal-zone lymphoma.
  • Marginal-zone lymphomas comprise the mucosa-associated lymphoid tissue (MALT) type (extranodal marginal-zone lymphoma [EMZL]), the nodal marginal zone B-cell lymphoma (NMZL) and the splenic MZL (SMZL).
  • These data have determined unique approach among all other lymphoma subtypes: the possibility of treating a subset of patients with antibiotics alone as first line of treatment.
  • Indeed, there is compelling evidence that histologic regressions can be achieved in most gastric MALT lymphomas by eradicating Helicobacter pylori infection.
  • However, molecular follow-up studies showed the persistence of the malignant clone in half of the cases in histologic remission after antibiotic treatment and transient, either histologic or molecular, relapses have been reported, too.
  • Differently from EMZL, both SMLZ and NMZL often present with disseminated disease at diagnosis.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Helicobacter Infections / drug therapy. Immunotherapy / methods. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, B-Cell, Marginal Zone / therapy

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  • (PMID = 16155028.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Number-of-references] 79
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65. Tedoldi S, Paterson JC, Cordell J, Tan SY, Jones M, Manek S, Dei Tos AP, Roberton H, Masir N, Natkunam Y, Pileri SA, Facchetti F, Hansmann ML, Mason DY, Marafioti T: Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas. J Pathol; 2006 Aug;209(4):454-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas.
  • High levels of Jaw1/LRMP mRNA have been found in germinal centre B-cells and in diffuse large B-cell lymphomas of 'germinal centre' subtype.
  • Jaw1/LRMP was highly expressed in germinal centre B-cells (in keeping with gene expression data), in 'monocytoid B-cells', and in splenic marginal zone B-cells.
  • It was absent, or present at only low levels, in mature T-cells, although cortical thymocytes were weakly positive.
  • Among lymphoid neoplasms, Jaw1/LRMP was found in germinal centre-derived lymphomas (follicle centre lymphoma, Burkitt's lymphoma, lymphocyte-predominant Hodgkin's disease) but not in T-cell neoplasms (with the exception of a single T lymphoblastic lymphoma).
  • Classical Hodgkin's disease and myeloma lacked Jaw1/LRMP but many cases of chronic lymphocytic leukaemia (but not mantle zone lymphoma) were Jaw1/LRMP-positive.
  • Approximately half of the marginal zone lymphomas were Jaw1/LRMP-positive.
  • In diffuse large B-cell lymphomas, Jaw1/LRMP was found in three-quarters (24/32) of the cases classified phenotypically as being of 'germinal centre' type, but it was also expressed in almost half (13/28) of the 'non-germinal centre' cases.
  • The fact that all three of these proteins are expressed in a significant proportion of diffuse large B-cell lymphomas assigned to the 'non-germinal centre' category indicates that the immunophenotypic categorization of diffuse large B-cell lymphoma according to cellular origin may be more complicated than currently understood.
  • Finally, the expression of Jaw1/LRMP in other types of lymphoma and in non-lymphoid tissues/tumours may be of interest in differential diagnosis and research.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gene Expression Regulation, Neoplastic. Germinal Center / chemistry. Lymphoma, B-Cell / chemistry. Lymphoma, Large B-Cell, Diffuse / chemistry. Membrane Proteins / analysis
  • [MeSH-minor] Adrenal Glands / chemistry. B-Lymphocytes / chemistry. B-Lymphocytes / ultrastructure. Biomarkers / analysis. Blotting, Western. Cell Line. Cerebral Cortex / chemistry. Epithelial Cells / chemistry. Humans. Immunohistochemistry / methods. Male. Neurons / chemistry. Palatine Tonsil / chemistry. Seminal Vesicles. Stomach

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  • [Copyright] Copyright 2006 Pathological Society of Great Britain and Ireland.
  • (PMID = 16739114.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / LRMP protein, human; 0 / Membrane Proteins
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66. Ruiz A, Reischl U, Swerdlow SH, Hartke M, Streubel B, Procop G, Tubbs RR, Cook JR: Extranodal marginal zone B-cell lymphomas of the ocular adnexa: multiparameter analysis of 34 cases including interphase molecular cytogenetics and PCR for Chlamydia psittaci. Am J Surg Pathol; 2007 May;31(5):792-802
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extranodal marginal zone B-cell lymphomas of the ocular adnexa: multiparameter analysis of 34 cases including interphase molecular cytogenetics and PCR for Chlamydia psittaci.
  • Extranodal marginal zone B-cell lymphomas of MALT type (MALT lymphomas) show site-dependent variations in their morphologic, phenotypic, and/or cytogenetic findings.
  • This report describes a comprehensive analysis of 34 ocular adnexa MALT lymphomas, including interphase fluorescence in situ hybridization for MALT lymphoma-associated cytogenetic abnormalities and polymerase chain reaction for Chlamydia psittaci, which has recently been suggested to be associated with ocular adnexa lymphomas.
  • A typical morphologic pattern was identified in 79% of cases, while overtly monocytoid cytology (12%), predominantly plasmacytic features (9%), and lymphoepithelial lesions (3%) were uncommon.
  • This study identifies the characteristic morphologic, phenotypic, and cytogenetic findings in ocular adnexa MALT lymphoma, including a subset differing from those arising at other anatomic sites.
  • The lack of C. psittaci in this series, in contrast to some prior reports, indicates that there may also be geographic heterogeneity in the pathogenesis of ocular adnexa MALT lymphoma.
  • [MeSH-major] Chlamydia Infections / pathology. Chlamydophila psittaci / isolation & purification. Lymphoma, B-Cell, Marginal Zone / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA, Bacterial / analysis. DNA, Neoplasm / analysis. Female. Humans. Interphase / genetics. Male. Middle Aged. Polymerase Chain Reaction. Retrospective Studies

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  • (PMID = 17460465.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Neoplasm
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67. Qiu L, Unger PD, Dillon RW, Strauchen JA: Low-grade mucosa-associated lymphoid tissue lymphoma involving the kidney: report of 3 cases and review of the literature. Arch Pathol Lab Med; 2006 Jan;130(1):86-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-grade mucosa-associated lymphoid tissue lymphoma involving the kidney: report of 3 cases and review of the literature.
  • Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue involving the kidney is rare.
  • The third case occurred in a 72-year-old man who had a history of periorbital mucosa-associated lymphoid tissue lymphoma and had been treated with surgery and radiation 1 year prior to this presentation.
  • Histologically, all 3 patients showed infiltrate of uniform small-to-medium-sized lymphocytes with irregular nuclear contours and abundant cytoplasm resembling centrocytes or monocytoid lymphoid cells.
  • [MeSH-major] Kidney Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology

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  • (PMID = 16390244.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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68. Kumarappan CT, Mandal SC: Antitumor activity of polyphenolic extract of Ichnocarpus frutescens. Exp Oncol; 2007 Jun;29(2):94-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PPE cytotoxicity was determined in vitro in U-937 monocytoid leukemia and K-562 erythroleukemia cell lines.
  • RESULTS: Results of in vivo study showed a significant decrease in tumor volume, viable tumor cell count and a significant increase of life span in the PPE treated group compared to untreated one: the life span of PPE treated animals increased by 53.41% (50 mg PPE/kg) and 73.95% (100 mg PPE/kg).
  • PPE (5, 10 and 20 microg/mL) effectively inhibits in vitro proliferation of U-937 and K-562 cell lines.
  • [MeSH-minor] Animals. Antioxidants / pharmacology. Body Weight / drug effects. Carcinoma, Ehrlich Tumor / drug therapy. Cell Count. Cell Line, Tumor. Cell Proliferation / drug effects. Cell Survival / drug effects. Dose-Response Relationship, Drug. Female. Free Radical Scavengers / pharmacology. Humans. Inhibitory Concentration 50. K562 Cells. Leukemia, Erythroblastic, Acute / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Male. Mice. Neoplasm Transplantation. Nitric Oxide / chemistry. Nitric Oxide / metabolism. Plant Leaves / chemistry. Polyphenols. Solvents / chemistry. Superoxides / metabolism. Survival Rate. Toxicity Tests, Acute. Transplantation, Homologous. Tumor Burden / drug effects. U937 Cells. alpha-Tocopherol / pharmacology

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  • (PMID = 17704739.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Antioxidants; 0 / Flavonoids; 0 / Free Radical Scavengers; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols; 0 / Solvents; 11062-77-4 / Superoxides; 31C4KY9ESH / Nitric Oxide; H4N855PNZ1 / alpha-Tocopherol
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69. Valbuena JR, Rassidakis GZ, Lin P, Atwell C, Georgakis GV, Younes A, Jones D, Medeiros LJ: Expression of heat-shock protein-90 in non-Hodgkin's lymphomas. Mod Pathol; 2005 Oct;18(10):1343-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
  • Heat-shock protein-90 (HSP90) inhibitors are currently being used in phase I clinical trials for treating patients with a variety of neoplasms including lymphomas.
  • Using immunohistochemical methods, we assessed for HSP90 expression in 412 cases of non-Hodgkin's lymphoma.
  • In B-cell lymphomas, HSP90 was moderately to strongly expressed in all cases of Burkitt's lymphoma (5/5, 100%), and in subsets of follicular lymphoma (17/28, 61%), diffuse large B-cell lymphoma (27/46, 59%), nodal marginal zone B-cell lymphoma (6/16, 38%), plasma cell neoplasms (14/39, 36%), small lymphocytic lymphoma/chronic lymphocytic leukemia (3/9, 33%), mantle cell lymphoma (12/38, 32%) and lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (3/10, 30%).
  • HSP90 was weakly expressed in six of 14 (43%) cases of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.
  • In T-cell lymphomas, HSP90 was moderately to strongly expressed in subsets of anaplastic large-cell lymphoma (14/24, 58%; 9/12 ALK+ and 5/12 ALK-), precursor-T-cell lymphoblastic leukemia/lymphoma (20/65, 31%), unspecified peripheral T-cell lymphoma (8/43, 23%) and angioimmunoblastic T-cell lymphoma (2/17, 12%).
  • We conclude that HSP90 is commonly expressed in a subset of many types of B- and T-cell lymphoma.
  • These data suggest that many lymphoma types are suitable targets for modulation of HSP90 activity, and that HSP90 inhibitors are a potential investigational therapy for lymphoma patients.
  • [MeSH-major] HSP90 Heat-Shock Proteins / biosynthesis. Lymphoma, Non-Hodgkin / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Lymph Nodes / metabolism. Lymphoma, B-Cell / metabolism. Lymphoma, T-Cell / metabolism

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  • (PMID = 16056252.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HSP90 Heat-Shock Proteins
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70. Takahashi T, Suzukawa M, Akiyama M, Hatao K: Auer rod-like cytoplasmic inclusion bodies in nodal marginal zone lymphoma cells. Int J Hematol; 2009 Mar;89(2):133-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auer rod-like cytoplasmic inclusion bodies in nodal marginal zone lymphoma cells.
  • [MeSH-major] Inclusion Bodies / pathology. Lymphoma, B-Cell, Marginal Zone / pathology
  • [MeSH-minor] Cell Shape. Female. Humans. Lymph Nodes / pathology. Middle Aged. Positron-Emission Tomography. Tomography

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  • (PMID = 19225724.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Yoon TY, Kim YG, Kim JW, Kim MK: Nodal marginal zone lymphoma in association with hydroa vacciniforme-like papulovesicular eruption, hypersensitivity to mosquito bites and insect bite-like reaction. Br J Dermatol; 2005 Jul;153(1):210-2
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  • [Title] Nodal marginal zone lymphoma in association with hydroa vacciniforme-like papulovesicular eruption, hypersensitivity to mosquito bites and insect bite-like reaction.
  • [MeSH-major] Hydroa Vacciniforme / complications. Hypersensitivity / complications. Insect Bites and Stings / complications. Lymphoma, B-Cell, Marginal Zone / complications. Skin Neoplasms / complications


72. Wang E, West D, Kulbacki E: An unusual nodal marginal zone lymphoma with bright CD10 expression: a potential diagnostic pitfall. Am J Hematol; 2010 Jul;85(7):546-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual nodal marginal zone lymphoma with bright CD10 expression: a potential diagnostic pitfall.
  • [MeSH-major] Lymphoma, B-Cell, Marginal Zone / diagnosis. Neprilysin / analysis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20575027.001).
  • [ISSN] 1096-8652
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
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73. Traverse-Glehen A, Verney A, Baseggio L, Felman P, Callet-Bauchu E, Thieblemont C, Ffrench M, Magaud JP, Coiffier B, Berger F, Salles G: Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin. Leukemia; 2007 Aug;21(8):1821-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin.
  • [MeSH-major] Antigens, CD95 / genetics. B-Cell-Specific Activator Protein / genetics. DNA-Binding Proteins / genetics. Lymphoma, B-Cell / genetics. Lymphoma, Follicular / genetics. Mutation / genetics. Proto-Oncogene Proteins c-pim-1 / genetics. Splenic Neoplasms / genetics. Transcription Factors / genetics. rho GTP-Binding Proteins / genetics

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  • (PMID = 17476282.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / B-Cell-Specific Activator Protein; 0 / BCL6 protein, human; 0 / DNA-Binding Proteins; 0 / PAX5 protein, human; 0 / RhoH protein, human; 0 / Transcription Factors; EC 2.7.11.1 / PIM1 protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-pim-1; EC 3.6.5.2 / rho GTP-Binding Proteins
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74. Wedgwood A, Medeiros LJ, Romaguera JE: CD20+ nodal marginal zone B-cell lymphoma with CD20-recurrence as an intracranial dural-based mass. Leuk Lymphoma; 2006 Oct;47(10):2253-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD20+ nodal marginal zone B-cell lymphoma with CD20-recurrence as an intracranial dural-based mass.
  • [MeSH-major] Antigens, CD20 / biosynthesis. Brain Neoplasms / pathology. Brain Neoplasms / therapy. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / therapy
  • [MeSH-minor] Adult. Brain / pathology. Female. Humans. Immunohistochemistry. Immunophenotyping. Lymphatic Metastasis. Lymphoma, B-Cell, Marginal Zone / diagnosis. Magnetic Resonance Imaging / methods. Neoplasm Metastasis. Recurrence. Spleen / pathology

  • MedlinePlus Health Information. consumer health - Brain Tumors.
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  • (PMID = 17071504.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD20
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75. Qiao SJ, Pei SL, Yu QK: [Nodular reactive hyperplasia of monocytoid B-cell in lymph node]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):753-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Nodular reactive hyperplasia of monocytoid B-cell in lymph node].
  • [MeSH-major] Lymph Nodes / pathology. Pseudolymphoma / pathology
  • [MeSH-minor] Adult. Antigens, CD20 / metabolism. Antigens, CD30 / metabolism. Antigens, CD45 / metabolism. Diagnosis, Differential. Female. Humans. Lymphoma, B-Cell / pathology

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  • (PMID = 16536328.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD30; EC 3.1.3.48 / Antigens, CD45
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76. Chen JH, Tsai WC, Ho CL: Secondary nodal marginal zone B cell lymphoma arising in primary mixed cellularity subtype of Hodgkin's lymphoma. Ann Hematol; 2009 May;88(5):501-3
MedlinePlus Health Information. consumer health - Hodgkin Disease.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary nodal marginal zone B cell lymphoma arising in primary mixed cellularity subtype of Hodgkin's lymphoma.
  • [MeSH-major] Hodgkin Disease / diagnosis. Lymphoma, B-Cell, Marginal Zone / diagnosis. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 19125250.001).
  • [ISSN] 1432-0584
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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77. Kojima M, Tsukamoto N, Miyazawa Y, Iijima M, Shimizu K, Masawa N: Nodal marginal zone B-cell lymphoma associated with Sjögren's syndrome: a report of three cases. Leuk Lymphoma; 2007 Jun;48(6):1222-4
MedlinePlus Health Information. consumer health - Sjogren's Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodal marginal zone B-cell lymphoma associated with Sjögren's syndrome: a report of three cases.
  • [MeSH-major] Lymphoma, B-Cell / complications. Sjogren's Syndrome / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Lymph Nodes / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Male. Middle Aged

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  • (PMID = 17577789.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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