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96. Mlika M, Chelly I, Benrhouma M, Haouet S, Horchani A, Zitouna MM, Kchir N: A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group. J Clin Med Res; 2010 Feb;2(1):47-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group.
  • Testicular lymphoma was first reported by Malassez and Curling in 1866.
  • Primary testicular lymphoma constitutes only 1 - 7% of all testicular neoplasms and less than 1% of all non Hodgkin lymphoma.
  • The authors report a new case of primary testicular lymphoma and highlight its diagnostic and therapeutic challenge.
  • Immunohistochemical study showed positivity for leukocytic common antigen (CD45), B-cell marker (CD20) and bcl 6.
  • The patient underwent full staging for lymphoma showing no evidence of extra-testicular involvement by lymphoma and no lymph nodes.
  • The diagnosis of stage I primary testicular large B-cell lymphoma of germinal center B-cell-like group was made.
  • Primary testicular lymphoma is a rare tumour whose diagnosis is based on histological findings.
  • There are non consensual etiological or predisposing factors.
  • Factors that have been linked to more favorable outcomes include younger patient age, localized disease, presence of sclerosis at pathologic analysis, smaller tumour size, lower histological tumor grade and lack of epididymal or spermatic cord involvement.
  • KEYWORDS: Testicular lymphoma; Germinal center; B-cell.

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  • (PMID = 22457702.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3299176
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97. Mollejo M, Rodríguez-Pinilla MS, Montes-Moreno S, Algara P, Dogan A, Cigudosa JC, Juarez R, Flores T, Forteza J, Arribas A, Piris MA: Splenic follicular lymphoma: clinicopathologic characteristics of a series of 32 cases. Am J Surg Pathol; 2009 May;33(5):730-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Splenic follicular lymphoma: clinicopathologic characteristics of a series of 32 cases.
  • The spleen is frequently involved in B-cell lymphomas other than splenic marginal zone lymphoma.
  • Here we describe a series of follicular lymphoma (FL) cases diagnosed in the spleen, consisting of 32 patients who presented clinically with splenomegaly, and slight or no peripheral lymphadenopathy.
  • The splenic specimen had a micronodular pattern, germinal center cytologic composition, and frequent presence of marginal zone-like cells at the periphery of the nodules.
  • Splenic FL cases could be divided into 2 main variants: one was similar to classic FL with t(14;18) and CD10 expression, whereas the other was characterized by a higher proliferation index and histologic grade, and was more frequently diagnosed as a disease restricted to the spleen.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Follicular / pathology. Splenic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Chromosomes, Human, Pair 14. Chromosomes, Human, Pair 18. Female. Gene Expression Regulation, Neoplastic. Humans. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Neprilysin / analysis. Polymerase Chain Reaction. Proto-Oncogene Proteins c-bcl-2 / analysis. Proto-Oncogene Proteins c-bcl-2 / genetics. Recurrence. Splenomegaly. Time Factors. Treatment Outcome

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  • (PMID = 19194277.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; EC 3.4.24.11 / Neprilysin
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98. Jaffe ES: Pathobiology of peripheral T-cell lymphomas. Hematology Am Soc Hematol Educ Program; 2006;:317-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathobiology of peripheral T-cell lymphomas.
  • Peripheral T-cell lymphomas (PTLs) are uncommon, accounting for fewer than 10% of all non-Hodgkin lymphomas.
  • Success in therapy of the PTLs has lagged behind that of aggressive B-cell lymphomas, and most PTLs have a poor prognosis.
  • In the WHO classification, clinical features, in conjunction with morphological and immunophenotypic criteria, are relied on to define most disease entities.
  • Functionally, T-cell lymphomas are related to the two major arms of the immune system, the innate and adaptive immune systems.
  • NK cells and T cells of the innate immune system recognize antigen in the absence of MHC antigens and are involved in mucosal immunity.
  • The lymphomas derived from these cells often involve cutaneous and mucosal sites.
  • The expression of cytotoxic molecules in these lymphomas may predispose to apoptosis by tumor cells and normal bystander cells.
  • Hepatosplenic T-cell lymphoma is a systemic disease derived from functionally immature innate effector cells, most often of gammadelta T-cell origin.
  • In contrast, most nodal T-cell lymphomas belong to the adaptive immune system.
  • Angioimmunoblastic T-cell lymphoma (AILT) is mostly likely derived from follicular helper T-cells (T(FH)), a finding that explains many of its pathological and clinical features.

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  • (PMID = 17124078.001).
  • [ISSN] 1520-4391
  • [Journal-full-title] Hematology. American Society of Hematology. Education Program
  • [ISO-abbreviation] Hematology Am Soc Hematol Educ Program
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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99. Liu L, Wang RP, Liu XH, Wang LX, Liu XY, Chen WJ, Liu LB: [The chronic effect of palmitic acid on apoptosis of pancreatic islet beta-cells and the mechanism]. Zhongguo Ying Yong Sheng Li Xue Za Zhi; 2009 Nov;25(4):553-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The chronic effect of palmitic acid on apoptosis of pancreatic islet beta-cells and the mechanism].
  • AIM: To investigate the chronic effect of palmitic acid (PA) on apoptosis of pancreatic islet beta-cells and the possible mechanism.
  • METHODS: Insulinoma cell line (MIN6 cells) were used in this study.
  • After being incubated for 48 h, Hoechst-PI and Annexin-V-FTTC/PI FACS were used to estimate the apoptosis in each group, Western-blotting assay was used to estimate the protein level of p-Akt, Akt, Bax and Bcl-2.
  • RESULTS: Chronic PA dose-dependently (1) decreased the availability and increased the apoptosis of MIN6 cells;.
  • (2) decreased the phosphorylation of Akt and Bcl-2, but had no significant effects on Akt and Bax.
  • CONCLUSION: Chronic PA dose-dependently induced apoptosis of MIN6 cells, and this effect was possibly regulated by Akt/Bcl-2.
  • [MeSH-minor] Animals. Cell Line, Tumor. Cells, Cultured. Insulinoma / pathology. Mice. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-bcl-2. Signal Transduction / drug effects. Signal Transduction / physiology. bcl-2-Associated X Protein / metabolism

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  • (PMID = 21158056.001).
  • [ISSN] 1000-6834
  • [Journal-full-title] Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
  • [ISO-abbreviation] Zhongguo Ying Yong Sheng Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Bax protein, mouse; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; 114100-40-2 / Bcl2 protein, mouse; 2V16EO95H1 / Palmitic Acid; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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100. Vujasinovic-Stupar N, Pejnovic N, Markovic O, Babic G: Influence of rituximab-CHOP therapy on clinical course and autoimmune parameters in rheumatoid arthritis associated with diffuse large B cell non-Hodgkin lymphoma. Ann Hematol; 2008 Sep;87(9):767-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of rituximab-CHOP therapy on clinical course and autoimmune parameters in rheumatoid arthritis associated with diffuse large B cell non-Hodgkin lymphoma.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arthritis, Rheumatoid / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy






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