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[Title] Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH).

Primary mediastinal B-cell lymphoma (PMBL) is an aggressive extranodal B-cell non-Hodgkin's lymphoma with specific clinical, histopathological and genomic features.

To characterize further the genotype of PMBL, we analyzed 37 tumor samples and PMBL cell lines Med-B1 and Karpas1106P using array-based comparative genomic hybridization (matrix- or array-CGH) to a 2.8k genomic microarray.

[MeSH-major] Chromosome Aberrations. Consensus Sequence. Gene Expression Profiling / methods. Lymphoma, B-Cell / genetics. Mediastinal Neoplasms / genetics

[MeSH-minor] Adult. Apoptosis / genetics. Cell Line, Tumor / metabolism. Chromosome Deletion. Female. Gene Amplification. Gene Deletion. Gene Expression Regulation, Neoplastic. Humans. Janus Kinases / genetics. Janus Kinases / metabolism. Male. Middle Aged. NF-kappa B / metabolism. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. STAT Transcription Factors / genetics. STAT Transcription Factors / metabolism

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(PMID = 17728785.001).

[ISSN] 1476-5551

[Journal-full-title] Leukemia

[ISO-abbreviation] Leukemia

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / NF-kappa B; 0 / Neoplasm Proteins; 0 / STAT Transcription Factors; EC 2.7.10.2 / Janus Kinases

   

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[Title] Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.

[MeSH-major] Carrier Proteins / genetics. Carrier Proteins / metabolism. Gene Expression Regulation, Neoplastic. Lymphoma, B-Cell / genetics. Mediastinal Neoplasms / genetics. Nuclear Proteins / genetics. Nuclear Proteins / metabolism

[MeSH-minor] Cell Nucleus / metabolism. Humans

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(PMID = 16871282.001).

[ISSN] 0887-6924

[Journal-full-title] Leukemia

[ISO-abbreviation] Leukemia

[Language] eng

[Grant] United Kingdom / Medical Research Council / / MC/ U132670597

[Publication-type] Letter; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / BCL11A protein, human; 0 / Carrier Proteins; 0 / Nuclear Proteins

   

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[Title] Primary mediastinal B-cell lymphoma: treatment and therapeutic targets.

Primary mediastinal B-cell lymphoma (PMBCL) is a recognised subtype of diffuse large B-cell lymphoma according to the WHO classification that represents approximately 5% of aggressive lymphomas, and 2% of all cases of lymphomas.

It presents with unique clinical, morphologic and immunophenotypic characteristics that define the disease.

[MeSH-major] Lymphoma, B-Cell / therapy. Mediastinal Neoplasms / therapy

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(PMID = 18452109.001).

[ISSN] 1029-2403

[Journal-full-title] Leukemia & lymphoma

[ISO-abbreviation] Leuk. Lymphoma

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor

[Number-of-references] 78

   

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[Title] [Primary mediastinal large B-cell lymphoma: histopathologic features. A specific tumour].

[Transliterated title] Le lymphome B à grandes cellules primitif du mediastin, une tumeur particulière. Aspects anatomopathologiques.

The diffuse large B-cell lymphomas of the mediastinum were long considered to be a variant of the classic forms of large B-cell lymphomas.

However, their clinical and radiological features and especially their histopathological variants point to other lymphoid tumours such as Hodgkin's disease or anaplastic lymphomas, thymic tumours, germ cell tumours or metastatic tumors.

The immunohistochemical findings are of prime importance in the diagnosis.

Currently, they represent a distinct entity among the large B-cell lymphomas, due to their clinical, pathological and molecular features as well as the outcome.

[MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Mediastinal Neoplasms / pathology

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[Copyright] Copyright 2009 Elsevier Masson SAS. All rights reserved.

(PMID = 20561485.001).

[ISSN] 0761-8417

[Journal-full-title] Revue de pneumologie clinique

[ISO-abbreviation] Rev Pneumol Clin

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

   

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[Title] Histopathology of Hodgkin's lymphoma.

In the last few years, there has been a greater understanding of the spectrum and biology of Hodgkin's lymphoma.

In standard texts, Hodgkin's lymphoma is classified as 2 distinct entities, namely nodular lymphocyte predominant Hodgkin's lymphoma and classical Hodgkin's lymphoma.

However, recent evidence suggests that classical Hodgkin's lymphoma is not a single disease.

Although the mixed cellularity and lymphocyte-depleted subtypes may be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology.

Nodular sclerosis Hodgkin's lymphoma, particularly those cases presenting with mediastinal disease, also seems related to primary mediastinal B-cell lymphoma.

As Hodgkin's lymphoma is a B-cell neoplasm, there is also a better appreciation today of cases that may be borderline with conventional B-cell lymphomas.

We present an update on the histopathological features of Hodgkin's lymphoma and the immunohistochemical tools available for diagnosis in the clinical setting.

[MeSH-minor] History, 19th Century. History, 20th Century. Humans. Immunohistochemistry. Lymphocytes / pathology. Lymphoma, B-Cell / classification. Lymphoma, B-Cell / history. Lymphoma, B-Cell / pathology

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(PMID = 19390308.001).

[ISSN] 1528-9117

[Journal-full-title] Cancer journal (Sudbury, Mass.)

[ISO-abbreviation] Cancer J

[Language] eng

[Publication-type] Historical Article; Journal Article; Review

[Publication-country] United States

[Number-of-references] 118

   

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[Title] [Case of malignant lymphoma associated with rheumatoid arthritis].

Chest radiograph and chest CT revealed marked mediastinal and right axillary lymph node swelling, interstitial shadows and bilateral pleural effusion.

A biopsy of the right axillary lymph node for histopathological examination revealed diffuse large B cell lymphoma.

As RA is associated with an increased risk of developing lymphoma, malignant lymphoma must be considered as a possible cause of the mediastinal swelling in a patient with RA.

[MeSH-major] Arthritis, Rheumatoid / complications. Lymphoma, B-Cell / drug therapy. Lymphoma, B-Cell / etiology

[MeSH-minor] Aged. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / administration & dosage. Diagnosis, Differential. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Lymph Nodes / pathology. Lymph Nodes / radiography. Mediastinum. Methotrexate / therapeutic use. Prednisolone / administration & dosage. Remission Induction. Rituximab. Tomography, X-Ray Computed. Vincristine / administration & dosage

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(PMID = 18318257.001).

[ISSN] 1343-3490

[Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society

[ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; YL5FZ2Y5U1 / Methotrexate

   

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[Title] NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.

Primary mediastinal large B-cell lymphoma (MLBCL) shares important clinical and molecular features with classic Hodgkin lymphoma, including nuclear localization of the nuclear factor kappaB (NFkappaB) subunit c-REL (reticuloendotheliosis viral oncogene homolog) in a pilot series.

Herein, we analyzed c-REL subcellular localization in additional primary MLBCLs and characterized NFkappaB activity and function in a MLBCL cell line.

The new primary MLBCLs had prominent c-REL nuclear staining, and the MLBCL cell line exhibited high levels of NFkappaB binding activity.

MLBCL cells expressing a superrepressor form of inhibitor of kappa B alpha signaling (IkappaB alpha) had a markedly higher rate of apoptosis, implicating constitutive NFkappaB activity in MLBCL cell survival.

The transcriptional profiles of newly diagnosed primary MLBCLs and diffuse large B-cell lymphomas (DLBCLs) were then used to characterize the NFkappaB target gene signatures of MLBCL and specific DLBCL subtypes.

MLBCLs expressed increased levels of NFkappaB targets that promote cell survival and favor antiapoptotic tumor necrosis factor alpha (TNFalpha) signaling.

In contrast, activated B cell (ABC)-like DLBCLs had a more restricted, potentially developmentally regulated, NFkappaB target gene signature.

Of interest, the newly characterized host response DLBCL subtype had a robust NFkappaB target gene signature that partially overlapped that of primary MLBCL.

In this large series of primary MLBCLs and DLBCLs, NFkappaB activation was not associated with amplification of the cREL locus, suggesting alternative pathogenetic mechanisms.

[MeSH-major] Gene Expression Regulation, Neoplastic. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Mediastinal Neoplasms / pathology. NF-kappa B / physiology. Proto-Oncogene Proteins c-rel / genetics

[MeSH-minor] Apoptosis. Cell Line, Tumor. Gene Expression Profiling. Humans

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(PMID = 15870177.001).

[ISSN] 0006-4971

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / NF-kappa B; 0 / Proto-Oncogene Proteins c-rel

   

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[Title] Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.

Mediastinal large B-cell lymphomas (MLBCLs) are considered as a subtype of diffuse large B-cell lymphoma; however, they exhibit completely different patterns of dissemination.

Since they share a number of surface markers with thymic B cells, a close relationship was assumed.

MLBCLs arise extranodally within the anterior mediastinum and have a low propensity to metastasize.

To address the preferential positioning of MLBCL, we focused on homeostatic chemokines involved in B-cell compartmental homing in secondary lymphoid organs, which are also capable of shaping lymphoid niches in ectopic sites.

Flow cytometry was used to identify the chemokine receptor profile on an MLBCL-derived cell line, Karpas1106 and on thymic B cells.

Using immunohistochemistry, we obtained an unexpectedly low-expression frequency for the chemokine receptors CXCR5 and CCR7 in primary lesions.

Although the mature B-cell marker CCR6 was absent in most cases, the lineage aberrant marker CCR9 emerged in the majority of MLBCL cases.

MLBCLs exhibit a diagnostic chemokine receptor profile that is instrumental in the discrimination from diffuse large B-cell lymphoma not otherwise specified and classical Hodgkin lymphoma.

Furthermore, we suggest that low-abundance expression of CCR7 and CXCR5 may hinder lymphoma cells from nodal dissemination.

[MeSH-major] Lymphoma, Large B-Cell, Diffuse / metabolism. Mediastinal Neoplasms / metabolism. Receptors, CCR7 / metabolism. Receptors, CXCR5 / metabolism

[MeSH-minor] Adolescent. B-Lymphocytes / metabolism. Cell Movement. Cells, Cultured. Chemotaxis. Child. Child, Preschool. Electrophoretic Mobility Shift Assay. Flow Cytometry. Humans. Immunoenzyme Techniques. Infant. NF-kappa B / metabolism. Thymus Gland / cytology. Thymus Gland / metabolism. Young Adult

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(PMID = 19536742.001).

[ISSN] 1097-0215

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / CCR7 protein, human; 0 / CXCR5 protein, human; 0 / NF-kappa B; 0 / Receptors, CCR7; 0 / Receptors, CXCR5

   

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[Title] Expression of Grb2 distinguishes classical Hodgkin lymphomas from primary mediastinal B-cell lymphomas and other diffuse large B-cell lymphomas.

Growth factor receptor-bound protein 2 is an adaptor molecule that mediates B-cell receptor (BCR) signaling pathways, but the expression of growth factor receptor-bound protein 2 in lymphoma tissues has not been reported.

We sought to characterize growth factor receptor-bound protein 2 protein expression in reactive tonsillar tissues and lymphoma tissues obtained from diagnostic biopsies of classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, diffuse large B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and 20 low-grade B-cell lymphomas.

Growth factor receptor-bound protein 2 expression was assessed in tissues by immunohistochemistry and in lymphoma cell lines by immunoblotting.

In reactive lymphoid tissues, growth factor receptor-bound protein 2 was expressed in the cytoplasm of B-cells and histiocytes but not T-cells.

Strong, cytoplasmic growth factor receptor-bound protein 2 expression was seen in the neoplastic cells of follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, splenic marginal zone lymphoma, primary mediastinal large B-cell lymphoma, diffuse large B-cell lymphoma, and nodular lymphocyte predominant Hodgkin lymphoma.

In contrast, only 10% of the classical Hodgkin lymphomas showed growth factor receptor-bound protein 2 expression in the neoplastic cells.

Growth factor receptor-bound protein 2 protein expression was detected by Western blotting in all lymphoma cell lines tested with higher levels in primary mediastinal large B-cell lymphoma compared with classical Hodgkin lymphoma cell lines.

These findings support a role for growth factor receptor-bound protein 2 in the diagnostically challenging workup of classical Hodgkin lymphoma versus primary mediastinal large B-cell lymphoma and warrant further studies to evaluate the biologic significance of growth factor receptor-bound protein 2 in the pathogenesis of classical Hodgkin lymphoma.

[MeSH-major] Biomarkers, Tumor / analysis. GRB2 Adaptor Protein / biosynthesis. Hodgkin Disease / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Mediastinal Neoplasms / diagnosis

[MeSH-minor] Blotting, Western. Diagnosis, Differential. Humans. Immunohistochemistry. Tissue Array Analysis

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(PMID = 19716163.001).

[ISSN] 1532-8392

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GRB2 Adaptor Protein; 0 / GRB2 protein, human

   

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[Title] Primary mediastinal B-cell lymphoma: detection of BCL2 gene rearrangements by PCR analysis and FISH.

Primary mediastinal large B-cell lymphoma (PMBCL) has a characteristic clinical presentation, morphology, and immunophenotype, representing a clinically favorable subgroup of diffuse large B-cell lymphoma (DLBCL).

By gene expression profiling (GEP), PMBCL shares features with classical Hodgkin lymphoma (cHL).

Of further interest, BCL6 gene mutations and BCL6 and/or MUM1 expression in a number of PMBCLs have supported an activated B-cell (ABC) origin.

Of the five with cytogenetics, two had a t(14;.

BCL2 protein expression by IHC analysis was variably detected in 21 out of 24 (strongly, uniformly expressed: 6, including all with a t(14;.

18) or a BCL2 gene rearrangement; moderately weakly expressed in a subset of the malignant cells: 15).

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[Cites] Br J Haematol. 1999 Oct;107(1):106-13 [10520030.001]

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(PMID = 19669206.001).

[ISSN] 1868-9256

[Journal-full-title] Journal of hematopathology

[ISO-abbreviation] J Hematop

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Other-IDs] NLM/ PMC2713480

   

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[Title] Practice guidelines for the management of extranodal non-Hodgkin's lymphomas of adult non-immunodeficient patients. Part I: primary lung and mediastinal lymphomas. A project of the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation.

Extranodal non-Hodgkin's lymphomas constitute 20-25% of overall non-Hodgkin's lymphomas cases and can be managed with very different therapeutic strategies.

Primary lung and mediastinal lymphomas were the objective of this part of the project.

The first-line therapy for non-MALT primary lung non-Hodgkin's lymphomas should include anthracycline-based chemotherapy with CHOP or CHOP-like, MACOP-B or MACOP-B-like regimens (grade D).

Second-line therapy with high-dose chemotherapy and autologous stem cell transplantation is recommended (grade B).

In patients with MALT primary lung non-Hodgkin's lymphomas, the recommended first-line therapy should include chlorambucil, CHOP, CHOP-like or fludarabine-containing regimens (grade B).

For treatment of primary mediastinal large B-cell lymphomas, the recommended first-line therapy is a chemotherapy and radiotherapy association (grade B).

Patients with refractory or relapsed disease should undergo rescue programs including intensive, non-cross-resistant debulking treatment followed, in chemosensitive patients, by high-dose chemotherapy and autologous stem cell transplantation (grade B).

[MeSH-major] Bone Marrow Transplantation. Lung Neoplasms / therapy. Lymphoma, Non-Hodgkin / therapy. Mediastinal Neoplasms / therapy. Practice Guidelines as Topic / standards

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(PMID = 18603558.001).

[ISSN] 1592-8721

[Journal-full-title] Haematologica

[ISO-abbreviation] Haematologica

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Italy

   

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[Title] Mucosa-associated lymphoid tissue lymphoma of the thymus: a case report with no evidence of MALT1 rearrangement.

We report a case of thymic mucosa-associated lymphoid tissue (MALT) lymphoma (TML) that presented as an asymptomatic mediastinal mass in a 40-year-old woman with a past history of Sjögren syndrome.

This case had the characteristic clinical and pathological features of TML, as found in most of the 24 previously reported cases, i.e., autoimmune context, especially Sjögren syndrome, IgA secretion, large epithelial cysts, lymphoepithelial lesions involving residual Hassal's corpuscles, epithelial cysts, and a marked plasmacytic differentiation with IgA expression.

Neoplastic cells were negative for MAL, a marker of primary mediastinal large B cell lymphoma (PMBL).

Altogether, these findings further support that among MALT lymphomas, TML have peculiar clinical and morphological characteristics and appear not to involve MALT1 rearrangement.

They also suggest the absence of a relationship between TML and PMBL.

[MeSH-major] Lymphoma, B-Cell, Marginal Zone / genetics. Lymphoma, B-Cell, Marginal Zone / pathology. Neoplasm Proteins / genetics. Thymus Neoplasms / genetics. Thymus Neoplasms / pathology

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(PMID = 15650839.001).

[ISSN] 0945-6317

[Journal-full-title] Virchows Archiv : an international journal of pathology

[ISO-abbreviation] Virchows Arch.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Immunoglobulin A; 0 / Neoplasm Proteins; EC 3.4.22.- / Caspases; EC 3.4.22.- / MALT1 protein, human

   

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[Title] Diagnostic accuracy of image-guided percutaneous fine needle aspiration biopsy of the mediastinum.

Interpreting a fine needle aspiration biopsy (FNAB) from the mediastinum is challenging as this location may harbor many lesions, including primary and metastatic tumors.

The aim of this study was to determine the diagnostic accuracy of FNAB performed percutaneously for evaluating mediastinal lesions.A retrospective study of 157 consecutive CT-guided transthoracic FNAB of the mediastinum was performed (1988-2004).

Direct smears (N = 145; average 13 slides/case), ThinPrep slides (N = 25), and adequate cell blocks (N = 131) were prepared from procured cytologic material.

A definitive diagnosis was rendered in 128 (82%) cases.

Primary neoplasms (N = 38) included 24 lymphomas (6 Hodgkin and 18 non-Hodgkin), 7 thymomas, 1 thymic carcinoma, and 6 peripheral nerve sheath tumors.

There were 4 non-neoplastic lesions (1 granulomatous process; 2 bronchogenic and 1 pericardial cyst), 1 case of undifferentiated malignant large cell neoplasm, 13 cases negative for malignancy, and 29 (18%) that were indeterminate, due largely to insufficient cellularity.

There were 6 discordant cases, including 5 FNAB that were of adequate cellularity but interpreted as negative for malignant cells (on subsequent histology 2 turned out to be Hodgkin lymphoma, 2 carcinomas, and 1 diffuse large cell lymphoma), and 1 diagnosed as thymoma that on histologic evaluation was a thymic large cell lymphoma.

Adequate diagnostic cytologic material was obtained by image-guided percutaneous FNAB of mediastinal lesions in 82% of our cases.

Sufficient material was available to make cell blocks and perform ancillary studies when necessary.

These data also show a high proportion of agreement (78%) between FNAB and subsequent histologic diagnoses for a wide variety of mediastinal lesions.

The majority of discordant cases were primarily interpretive, with a final cytologic diagnosis negative for malignancy.

Only one problematic case misdiagnosed on FNAB as thymoma was found on subsequent surgical excision to be a thymic large B cell lymphoma.

Therefore, percutaneous FNAB of the mediastinum is a diagnostically helpful, minimally invasive procedure that can be performed in patients of all ages as part of the evaluation of a mediastinal mass lesion.

[MeSH-major] Biopsy, Fine-Needle. Mediastinal Neoplasms / diagnosis. Mediastinum / pathology. Surgery, Computer-Assisted

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[Copyright] (c) 2007 Wiley-Liss, Inc.

(PMID = 17924408.001).

[ISSN] 8755-1039

[Journal-full-title] Diagnostic cytopathology

[ISO-abbreviation] Diagn. Cytopathol.

[Language] eng

[Publication-type] Evaluation Studies; Journal Article

[Publication-country] United States

   

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[Title] Isolated renal relapse of a case with non-Hodgkin's lymphoma.

A 29-year-old woman with left pleural effusion and a mass in anterior mediastinum was admitted.

The patient was in remission after six cycles of ABVD followed by mediastinal radiotherapy.

Ultrasound guided renal biopsy revealed diffuse large B cell lymphoma.

Retrospective re-evaluation of the archival specimens of the mediastinal mass was also consistent with diffuse large B cell lymphoma.

After induction chemotherapy (four cycles of DHAP) she underwent high dose chemotherapy (BEAM) and autologous peripheral blood stem cell transplantation.

In conclusion, renal involvement during advanced lymphoma is quite common but isolated renal relapse in NHL is a rare situation.

Although renal infiltration generally shows a poor prognosis, long-term survival may be achieved with high dose chemotherapy and autologous peripheral blood stem cell transplantation.

[MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / therapy. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy

[MeSH-minor] Adult. Female. Humans. Peripheral Blood Stem Cell Transplantation. Secondary Prevention

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(PMID = 19437146.001).

[ISSN] 1559-131X

[Journal-full-title] Medical oncology (Northwood, London, England)

[ISO-abbreviation] Med. Oncol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Primary mediastinal large B-cell lymphoma in an HIV-infected patient.

HIV-related non-Hodgkin lymphoma is well documented in the literature.

We report a case of an HIV-infected patient who presents with primary mediastinal large B-cell lymphoma.

On review of the literature, this appears to be the first documented case of this subtype of large B-cell non-Hodgkin lymphoma seen in an HIV-infected patient.

[MeSH-major] Lymphoma, AIDS-Related / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Mediastinal Neoplasms / diagnosis

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(PMID = 15767818.001).

[ISSN] 0002-9629

[Journal-full-title] The American journal of the medical sciences

[ISO-abbreviation] Am. J. Med. Sci.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol

   

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[Title] Primary mediastinal (thymic) large B cell lymphoma with aberrant expression of CD3: a case report with review of the literature.

We report the first case of primary mediastinal large B cell lymphoma (PMBL) with aberrant expression of CD3.

PMBL is a subtype of diffuse large B cell lymphoma (DLBCL) and usually presents with bulky mediastinal lesions.

Of the 14 total cases, 6 are pyothorax-associated lymphoma, 4 are conventional DLBCL, 2 are plasmablastic lymphoma, one is primary effusion lymphoma and one is PMBL.

[MeSH-major] Antigens, CD3 / metabolism. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / pathology. Mediastinal Neoplasms / metabolism. Mediastinal Neoplasms / pathology

[MeSH-minor] Adult. Biopsy. Female. Humans. Radiography. Thymus Neoplasms / diagnostic imaging. Thymus Neoplasms / metabolism. Thymus Neoplasms / pathology

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(PMID = 20131102.001).

[ISSN] 1865-3774

[Journal-full-title] International journal of hematology

[ISO-abbreviation] Int. J. Hematol.

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] Japan

[Chemical-registry-number] 0 / Antigens, CD3

[Number-of-references] 15

   

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[Title] Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Classical Hodgkin lymphoma (cHL) and mediastinal large B-cell lymphoma (MLBCL) are lymphoid malignancies with certain shared clinical, histologic, and molecular features.

Primary cHLs and MLBCLs include variable numbers of malignant cells within an inflammatory infiltrate, suggesting that these tumors escape immune surveillance.

Herein, we integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines.

We extend these findings to laser-capture microdissected primary Hodgkin Reed-Sternberg cells and primary MLBCLs and find that programmed cell death-1 (PD-1) ligand/9p24.1 amplification is restricted to nodular sclerosing HL, the cHL subtype most closely related to MLBCL.

Using quantitative immunohistochemical methods, we document the association between 9p24.1 copy number and PD-1 ligand expression in primary tumors.

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(PMID = 20628145.001).

[ISSN] 1528-0020

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / P01 CA092625

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human; 0 / Intercellular Signaling Peptides and Proteins; 0 / PDCD1LG2 protein, human; 0 / Programmed Cell Death 1 Ligand 2 Protein; EC 2.7.10.2 / Janus Kinase 2

[Other-IDs] NLM/ PMC2995356

   

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[Title] Extrinsic compression of the pulmonary artery by primary mediastinal large B-cell lymphoma.

[MeSH-major] Lymphoma, B-Cell / ultrasonography. Pulmonary Artery / ultrasonography. Thymus Neoplasms / ultrasonography

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(PMID = 19149803.001).

[ISSN] 1365-2141

[Journal-full-title] British journal of haematology

[ISO-abbreviation] Br. J. Haematol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

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[Title] Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.

SOCS-1 silencing by aberrant DNA methylation contributes to oncogenesis in various B-cell neoplasias and carcinomas.

Recently, we showed an alternative loss of SOCS-1 function due to deleterious SOCS-1 mutations in a major subset of primary mediastinal B-cell lymphoma (PMBL) and in the PMBL line MedB-1, and a biallelic SOCS-1 deletion in PMBL line Karpas1106P.

For both cell lines our previous data demonstrated retarded JAK2 degradation and sustained phospho-JAK2 action leading to enhanced DNA binding of phospho-STAT5.

Here, we analysed SOCS-1 in laser-microdissected Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL).

We detected SOCS-1 mutations in HRS cells of eight of 19 cHL samples and in three of five Hodgkin lymphoma (HL)-derived cell lines by sequencing analysis.

Collectively, these findings support the concept that PMBL and cHL share many overlapping features, and that defective tumor suppressor gene SOCS-1 triggers an oncogenic pathway operative in both lymphomas.

[MeSH-major] Cell Nucleus / metabolism. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Hodgkin Disease / genetics. Intracellular Signaling Peptides and Proteins / genetics. Mutation. Repressor Proteins / genetics. STAT5 Transcription Factor / metabolism. Suppressor of Cytokine Signaling Proteins / genetics

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(PMID = 16532038.001).

[ISSN] 0950-9232

[Journal-full-title] Oncogene

[ISO-abbreviation] Oncogene

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Repressor Proteins; 0 / SOCS1 protein, human; 0 / STAT5 Transcription Factor; 0 / Suppressor of Cytokine Signaling Proteins

   

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[Title] Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma.

In recent years, overlap in biologic and morphologic features has been identified between classic Hodgkin lymphoma (cHL) and B-cell non-Hodgkin lymphoma.

We undertook a study of "mediastinal gray zone lymphomas" (MGZL), with features transitional between cHL nodular sclerosis (NS) and primary mediastinal large B-cell lymphoma (MLBCL) to better understand the morphologic and immunophenotypic spectrum of such cases.

We also studied 6 cases of composite or synchronous lymphoma with two distinct components at the same time (cHL-NS and MLBCL) and 9 sequential cases with MLBCL and cHL-NS at different times.

All patients had a large mediastinal mass.

Immunohistochemical studies focused on markers known to discriminate between cHL and MLBCL, including B-cell transcription factors.

Of the gray zone cases, 11 had morphology reminiscent of cHL-NS, but with unusual features, including a large number of mononuclear variants, diminished inflammatory background, absence of classic Hodgkin phenotype, and strong CD20 expression (11 of 11).

B-cell transcription factor expression in the gray zone cases more closely resembled MLBCL than cHL with expression of Pax5, Oct2, and BOB.1 in all but 1 case studied (14 of 15).

Two cases of sequential lymphoma showed rearrangements of the IgH gene of identical size: one in which MLBCL was the first diagnosis and one in which MLBCL was diagnosed at relapse, indicating clonal identity for the two components of cHL and MLBCL.

Further support for a relationship between MLBCL and cHL-NS is provided by composite and metachronous lymphomas in the same patient, as well as the existence of MGZL with transitional morphology and phenotype.

[MeSH-major] Hodgkin Disease / pathology. Lymphoma, B-Cell / pathology. Mediastinal Neoplasms / pathology

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(PMID = 16224207.001).

[ISSN] 0147-5185

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] eng

[Grant] United States / Intramural NIH HHS / /

[Publication-type] Journal Article; Research Support, N.I.H., Intramural

[Publication-country] United States

   

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[Title] Large B-cell lymphoma with Hodgkin's features.

AIMS: To describe the features of a series of nine cases of diffuse large B-cell lymphoma (DLBCL) showing morphological and immunophenotypic features that are intermediate with Hodgkin's lymphoma (HL).

METHODS AND RESULTS: Most cases (6/9) presented as mediastinal tumours affecting young males, while the other three cases arose in extramediastinal locations.

Histopathologically, tumours showed diffuse large cell areas in a polymorphous background, with pleomorphic cytology and the common presence of Hodgkin's and Reed-Sternberg cells.

Immunophenotypically, tumours shared features of DLBCL and classical HL, with expression of CD30, CD15 (6/9), and a full B-cell profile including CD45RB, CD20, CD79a and OCT2.

CONCLUSIONS: These findings suggest that DLBCLs with HL features constitute a distinctive subgroup of aggressive lymphomas whose neoplastic growth and peculiar characteristics could be facilitated by a particular microenvironment found in the mediastinum.

[MeSH-major] Hodgkin Disease / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology

[MeSH-minor] Adult. Aged. Antigens, CD / analysis. DNA-Binding Proteins / analysis. DNA-Binding Proteins / genetics. Diagnosis, Differential. Female. Gene Rearrangement. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Ki-67 Antigen / analysis. Male. Middle Aged. Mutation. Neoplasm Staging. Proto-Oncogene Proteins / analysis. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins c-bcl-2 / analysis. Proto-Oncogene Proteins c-bcl-6. Transcription Factors / analysis. Transcription Factors / genetics. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / genetics

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(PMID = 15982329.001).

[ISSN] 0309-0167

[Journal-full-title] Histopathology

[ISO-abbreviation] Histopathology

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antigens, CD; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Proto-Oncogene Proteins c-bcl-6; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53

   

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[Title] Primary mediastinal large B-cell lymphomas treated with dose-intensified CHOP alone or CHOP combined with radiotherapy.

We retrospectively reviewed 105 cases of primary mediastinal large B-cell lymphoma (PMLBL).

Radiotherapy was delivered to patients with a lymphoma proven sensitive to CHOP who could receive irradiation for localised disease.

[MeSH-minor] Adult. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Lymphoma, Large B-Cell, Diffuse / drug therapy. Lymphoma, Large B-Cell, Diffuse / radiotherapy. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / radiotherapy. Prednisone / administration & dosage. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome. Vincristine / administration & dosage

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(PMID = 18766963.001).

[ISSN] 1029-2403

[Journal-full-title] Leukemia & lymphoma

[ISO-abbreviation] Leuk. Lymphoma

[Language] eng

[Publication-type] Evaluation Studies; Journal Article

[Publication-country] England

[Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol

   

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[Title] Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line.

Primary mediastinal B-cell lymphoma (PMBL) is a well-defined subtype of diffuse large B-cell lymphoma.

JAK2, mapping in this region, is presently regarded as a candidate oncogene because expression profiling showed high Janus kinase-2 (JAK2) transcript levels and JAK2 was found to be constitutively phosphorylated in mediastinal B-cell lymphomas.

We confirm that in the MedB-1 mediastinal B-cell line, harboring a trisomy 9, JAK2 transcription is elevated and the product is highly phosphorylated.

This unexpected finding coincides with a biallelic mutation of the suppressor of cytokine signaling-1 (SOCS-1) gene in this cell, which abrogates SOCS box function of the protein.

Ectopic expression of wild-type (wt) SOCS-1 in MedB-1 leads to growth arrest and dramatic reduction of phospho-JAK2 and its downstream partner phospho-signal transducer and activator of transcription-5 (phospho-STAT5).

Of note, SOCS-1 mutations are also present in the parental tumor of MedB-1 and were detected in 9 of 20 PMBLs.

[MeSH-major] Intracellular Signaling Peptides and Proteins / genetics. Lymphoma, B-Cell / metabolism. Mediastinal Neoplasms / metabolism. Mutation. Protein Processing, Post-Translational / genetics. Protein-Tyrosine Kinases / metabolism. Proto-Oncogene Proteins / metabolism. Repressor Proteins / genetics. Suppressor of Cytokine Signaling Proteins / genetics. Tumor Suppressor Proteins / genetics

[MeSH-minor] Alleles. Cell Line, Tumor. Chromosomes, Human, Pair 9 / genetics. Chromosomes, Human, Pair 9 / metabolism. Cyclin D1 / genetics. Cyclin D1 / metabolism. Gene Expression Regulation, Leukemic / genetics. Humans. Janus Kinase 2. Phosphorylation. Retinoblastoma Protein / genetics. Retinoblastoma Protein / metabolism. STAT5 Transcription Factor / genetics. STAT5 Transcription Factor / metabolism. Signal Transduction / genetics. Trisomy / genetics

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(PMID = 15572583.001).

[ISSN] 0006-4971

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; 0 / Retinoblastoma Protein; 0 / SOCS1 protein, human; 0 / STAT5 Transcription Factor; 0 / Suppressor of Cytokine Signaling Proteins; 0 / Tumor Suppressor Proteins; 136601-57-5 / Cyclin D1; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2

   

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[Title] Primary mediastinal large B-cell lymphoma.

Primary mediastinal large B-cell lymphoma (PMLBCL) is a unique type of B-cell lymphoma probably arising from a putative thymic medulla B-cell.

It constitutes 6-10% of all diffuse large B-cell lymphomas (DLBCL), occurring more often in young females.

PMLBCL is characterized by a diffuse proliferation of medium to large B-cells associated with sclerosis and a degree of compartmentalisation.

The gene expression signature of PMLBCL seems to be much closer to classic Hodgkin lymphoma than to DLBCL.

PMLBCL is characterized by a locally invasive anterior mediastinal mass, often producing cough, chest pain, dyspnea, and superior vena cava syndrome.

Features associated with poor prognosis are poor performance status, pericardial effusion, bulky disease, high serum LDH at diagnosis, and a compromised dose-intensity of anthracycline and cyclophosphamide.

[MeSH-major] Lymphoma, B-Cell. Mediastinal Neoplasms

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(PMID = 18774728.001).

[ISSN] 1040-8428

[Journal-full-title] Critical reviews in oncology/hematology

[ISO-abbreviation] Crit. Rev. Oncol. Hematol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Ireland

[Chemical-registry-number] 0 / Neoplasm Proteins; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol

[Number-of-references] 75

   

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Other described sites of uptake include the mediastinum and retroperitoneum.

We present examples of 2 cases of atypical diffuse brown fat uptake seen in the subcutaneous fat of the thighs, abdomen, and pelvis.

Although rare in our experience, knowledge of this condition may prevent misinterpretation of this finding as an infiltrative condition of the skin, such as lymphoma.

[MeSH-minor] Adolescent. False Positive Reactions. Humans. Lymphoma, Large B-Cell, Diffuse / diagnosis. Male. Middle Aged. Rhabdomyosarcoma, Alveolar / diagnosis

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(PMID = 17710017.001).

[ISSN] 0363-9762

[Journal-full-title] Clinical nuclear medicine

[ISO-abbreviation] Clin Nucl Med

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Expression of TP73L is a helpful diagnostic marker of primary mediastinal large B-cell lymphomas.

Primary mediastinal large B-cell lymphoma is a well-defined lymphoma entity whose molecular pathogenesis is incompletely understood and also lacking well-established diagnostic markers.

Recently, the presence of overlapping features between classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma was highlighted by gene expression profiling as well as morphological studies.

We investigated the expression of TP73L (commonly known as p63) isoforms in primary mediastinal large B-cell lymphoma at both protein and mRNA level, and demonstrated the exclusive presence of transactivating (TA) isoforms in all cases.

We also demonstrated that TP73L is expressed in a subset of germinal center B-cells, as well as in some diffuse large B-cell lymphomas, but it is never present in classical Hodgkin lymphoma.

Nodular lymphocyte predominant Hodgkin's lymphoma also showed TP73L positivity by immunohistochemistry.

Isoform analysis by real-time PCR showed that TA-TP73Lalpha is the most represented in primary mediastinal large B-cell lymphoma, but TA-TP73Lgamma is the most differentially expressed in comparison to both germinal center B-cells and diffuse large B-cell lymphomas.

TP73L expression proved a useful diagnostic marker of primary mediastinal large B-cell lymphoma, and gave new insights in to the molecular pathways playing a role in this lymphoma.

[MeSH-major] Hodgkin Disease / diagnosis. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Mediastinal Neoplasms / diagnosis. Phosphoproteins / biosynthesis. Trans-Activators / biosynthesis

[MeSH-minor] Biomarkers, Tumor / analysis. DNA-Binding Proteins. Diagnosis, Differential. Gene Expression. Gene Expression Profiling. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Protein Isoforms / biosynthesis. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors. Tumor Suppressor Proteins

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[Copyright] Modern Pathology (2005) 18, 1448-1453. doi:10.1038/modpathol.3800440; published online 13 May 2005.

(PMID = 15920542.001).

[ISSN] 0893-3952

[Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

[ISO-abbreviation] Mod. Pathol.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / RNA, Messenger; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins

   

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[Title] Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma.

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) in activated B lymphocytes and is potentially implicated in genomic instability of B-cell malignancies.

For unknown reasons, B-cell neoplasms often lack SHM and CSR in spite of high AID expression.

Here, we show that primary mediastinal B-cell lymphoma (PMBL), an immunoglobulin (Ig)-negative lymphoma that possesses hypermutated, class-switched Ig genes, expresses high levels of AID with an intact primary structure but does not do CSR in 14 of 16 cases analyzed.

Interleukin-4/CD40L costimulation induced CSR and a marked up-regulation of germ-line transcription in the PMBL-derived cell line MedB-1.

In the PMBL cell line Karpas 1106P, CSR was not inducible and germ-line transcription remained low on stimulation.

Thus, accessibility of the target sequences seems to be a major limiting factor for AID-dependent somatic gene diversification in PMBL.

[MeSH-major] Cytidine Deaminase / biosynthesis. Cytidine Deaminase / chemistry. Gene Expression Regulation, Neoplastic. Lymphoma, B-Cell / metabolism

[MeSH-minor] Cell Line, Tumor. Cloning, Molecular. Cyclic AMP-Dependent Protein Kinases / metabolism. Genes, Immunoglobulin. Humans. Immunoglobulin Class Switching. Mediastinal Neoplasms / metabolism. RNA, Messenger / metabolism. Transcription, Genetic. Transfection. Up-Regulation

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(PMID = 17638864.001).

[ISSN] 0008-5472

[Journal-full-title] Cancer research

[ISO-abbreviation] Cancer Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.11.11 / Cyclic AMP-Dependent Protein Kinases; EC 3.5.4.- / AICDA (activation-induced cytidine deaminase); EC 3.5.4.5 / Cytidine Deaminase

   

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[Title] Successfully treated massive pulmonary thromboembolism and thrombus in the right atrium due to diffuse malignant lymphoma: a case report.

A 40-year-old man presented with massive pulmonary embolism related to diffuse large B cell lymphoma.

Echocardiography and thoracic computed tomography indicated pulmonary thromboembolism due to deep venous thromboembolism, associated with a mass in the anterior mediastinum and a 5 x 8 cm mass in the left pelvis compressing the left femoral vein.

Soon after this surgery, his hemodynamic state recovered and excision of the left cervical lymph node revealed diffuse large B cell lymphoma.

Venous compression by the lymphoma mass had caused hemostasis and thrombus formation in the present case.

[MeSH-major] Lymphoma, B-Cell / complications. Lymphoma, Non-Hodgkin / complications. Pulmonary Embolism / etiology. Pulmonary Embolism / surgery

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(PMID = 17007241.001).

[ISSN] 0914-5087

[Journal-full-title] Journal of cardiology

[ISO-abbreviation] J Cardiol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Gains of REL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein.

Gains or amplifications of the REL locus are frequently seen in primary mediastinal B-cell lymphoma (PMBL).

In classical Hodgkin's lymphoma, genomic overrepresentation of REL correlated with nuclear REL protein accumulation.

To investigate the correlation between REL gene copies and its RNA and protein expression in PMBL, we analyzed genomic, transcriptional, and protein levels in 20 PMBLs and the PMBL derived cell lines MedB-1 and Karpas1106P.

We found gains/amplifications in 75% of the PMBLs by fluorescence in situ hybridization (FISH) and genomic REL overrepresentation in the PMBL lines.

Three of the five PMBLs with amplifications displayed elevated REL transcripts, while only 3/10 PMBLs with gains showed increased REL transcripts by real-time PCR.

One PMBL without gains displayed increased REL transcription.

REL protein expression exhibited a variable pattern across the PMBLs except for a single case that was completely negative by immunohistochemistry despite having gained REL.

Although transcript levels were generally low and nuclear REL staining was weak in the lymphoma cell lines, these nevertheless exhibited high NF-kappaB activation.

In conclusion, the frequent genomic overrepresentation of REL in PMBL does not necessarily trigger an increased transcription/translation of REL.

However, combined genomic and protein analysis revealed a significant association of gained REL and nuclear REL accumulation at the single cell level.

[MeSH-major] Cell Nucleus / metabolism. Lymphoma, B-Cell / metabolism. Mediastinal Neoplasms / metabolism. Proto-Oncogene Proteins c-rel / metabolism

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[Copyright] (c) 2007 Wiley-Liss, Inc.

(PMID = 17243160.001).

[ISSN] 1045-2257

[Journal-full-title] Genes, chromosomes & cancer

[ISO-abbreviation] Genes Chromosomes Cancer

[Language] eng

[Grant] United Kingdom / Medical Research Council / / MC/ U132670597

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Proto-Oncogene Proteins c-rel

   

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[Title] [Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line].

[Transliterated title] Die biallelische Mutation von SOCS-1 verhindert den Abbau von JAK2 und prolongiert die Wirkung von phospho-JAK2 in der mediastinalen B-Zell Lymphomlinie MedB-1.

Primary mediastinal B-cell lymphoma (PMBL) is a well-defined subtype of diffuse large B-cell lymphoma.

JAK2, mapping in this region, is presently regarded as a candidate oncogene since expression profiling showed high JAK2 transcript levels and JAK2 was found to be constitutively phosphorylated in mediastinal B-cell lymphomas.

We confirm that in the MedB-1 mediastinal B-cell line, harbouring a trisomy 9, JAK2 transcription is elevated and the product is highly phosphorylated.

This unexpected finding coincides with a biallelic mutation of the SOCS-1 gene in this cell, which abrogates SOCS box function of the protein.

Of note, the SOCS-1 mutations are also present in the parental tumor of MedB-1 and were detected in 9 of 20 PMBL.

[MeSH-major] Janus Kinase 2 / metabolism. Lymphoma, B-Cell / genetics. Mediastinal Neoplasms / genetics. Mutation. Suppressor of Cytokine Signaling Proteins / genetics

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(PMID = 18035697.001).

[ISSN] 0070-4113

[Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie

[ISO-abbreviation] Verh Dtsch Ges Pathol

[Language] ger

[Publication-type] English Abstract; Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / SOCS1 protein, human; 0 / Suppressor of Cytokine Signaling Proteins; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2

   

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[Title] Fine-needle aspiration of a primary mediastinal large B-cell lymphoma: a case report with cytologic, histologic, and flow cytometric considerations.

Fine-needle aspiration (FNA) cytology and immunophenotyping by flow cytometry (FCM) are increasingly being used for diagnosing and subclassifying lymphoma in the REAL/WHO classification.

Herein, we report a case of primary mediastinal large B-cell lymphoma (PMBL), a subtype of diffuse large B-cell lymphoma in the WHO classification, diagnosed by FNA cytology in conjunction with FCM.

CT scan revealed a 5-cm anterior mediastinal mass and mediastinal lymphadenopathy.

Endoscopic ultrasound-guided FNA of a 4.5-cm subcarinal lymph node showed medium to large atypical lymphocytes with scant to moderate finely vacuolated cytoplasm.

Malignant large cell lymphoma was cytologically diagnosed.

FCM, performed on a portion of the FNA specimen, demonstrated large B cells devoid of surface immunoglobulin expression, the characteristic immunophenotype of PMBL.

The histologic diagnosis was PMBL.

Touch-imprint cytology of the histologic specimen showed large cells with a narrow rim of clear cytoplasm and prominent outer cell border.

In the presence of a mediastinal mass, FNA cytology in conjunction with FCM can effectively diagnose PMBL in the appropriate clinical setting.

[MeSH-major] Lymphoma, B-Cell / pathology. Mediastinal Neoplasms / pathology

[MeSH-minor] Antigens, CD / analysis. Biopsy, Fine-Needle. Female. Flow Cytometry. Humans. Lymphoma, Large B-Cell, Diffuse / pathology. Middle Aged

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(PMID = 15880713.001).

[ISSN] 8755-1039

[Journal-full-title] Diagnostic cytopathology

[ISO-abbreviation] Diagn. Cytopathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD

   

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[Title] BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas.

In a previous study we demonstrated high expression of the non-coding BIC gene in the vast majority of Hodgkin's lymphomas (HLs).

Evidence suggesting that BIC is a primary microRNA transcript containing the mature microRNA-155 (miR-155) as part of a RNA hairpin is now accumulating.

We therefore analysed HL cell lines and tissue samples to determine whether miR-155 is also expressed in HL.

However, in diffuse large B cell lymphoma (DLBCL) and primary mediastinal B cell lymphoma (PMBL), significant percentages of positive tumour cells were observed in 12/18 and 8/8 cases.

A higher proportion of tumour cells were positive for BIC in DLBCL with activated B cell-like phenotype than in DLBCL with germinal centre B cell-like phenotype.

Northern blot analysis showed expression of miR-155 in all DLBCL and PMBL derived cell lines and tissue samples analysed.

In summary, we demonstrate expression of primary microRNA BIC and its derivative miR-155 in HL, PMBL and DLBCL.

[MeSH-major] Lymphoma / genetics. Mediastinal Neoplasms / genetics. MicroRNAs / genetics. Receptors, Antigen, B-Cell / genetics

[MeSH-minor] Cell Line, Tumor. Hodgkin Disease / genetics. Humans. Immunohistochemistry / methods. In Situ Hybridization / methods. Lymphoma, B-Cell / genetics. Lymphoma, Large B-Cell, Diffuse / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods

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[Copyright] Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

(PMID = 16041695.001).

[ISSN] 0022-3417

[Journal-full-title] The Journal of pathology

[ISO-abbreviation] J. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Neoplasm; 0 / Receptors, Antigen, B-Cell

   

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[Title] [Flow cytometry for the study of mediastinal tumors with abundant lymphoid elements].

[Transliterated title] La citometría de flujo en el estudio de tumores mediastinales ricos en elementos linfoides.

The anterior mediastinum is a common site of tumors with abundant lymphoid elements.

Flow cytometry is a useful complementary technique to analyze this type of tumors, which provides qualitative and quantitative information.

A differential diagnosis can be sometimes made between thymoma and precursor T-lymphoblastic lymphoma (T-LBL).

A total of 38 mediastinal tumors were analyzed, and samples were separated for flow cytometry.

Flow cytometry data from thymomas and normal thymic tissue were compared with 42 cases of T-LBL from other anatomical locations.

Among 38 mediastinal tumors, we found 6 benign lesions, 9 diffuse large B-cell lymphomas (DLBCL), 10 Hodgkin lymphomas (HL), 11 thymomas and 2 T-LL.

Flow cytometry helped differentiate 10 cases of HL and 4 benign lesions from other lymphomas (DLBCL, T-LBL, etc.).

CD3, CD4 and CD8 expressions were most useful for the differential diagnosis of thymomas and T-LL.

To conclude, flow cytometry is a valid complementary technique, which promptly provides information on mediastinal lesions, requiring small quantities of tissue for both early diagnosis and follow up of these diseases.

[MeSH-major] Antigens, CD / analysis. Biomarkers, Tumor. Flow Cytometry. Mediastinal Neoplasms / pathology. Thymoma / pathology. Thymus Neoplasms / pathology

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(PMID = 18416319.001).

[ISSN] 0025-7680

[Journal-full-title] Medicina

[ISO-abbreviation] Medicina (B Aires)

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Argentina

[Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD3; 0 / Antigens, CD4; 0 / Antigens, CD8; 0 / Biomarkers, Tumor

   

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[Title] Primary mediastinal B-cell lymphoma.

Primary mediastinal B-cell lymphoma is a discrete clinicopathologic entity.

Molecular analysis reveals it to be distinct from other types of large B-cell lymphoma, and retrospective analysis suggests that it may respond better to multi-agent chemotherapy regimens than to the more commonly used CHOP.

The addition of rituximab may mitigate such differences, and may also diminish the role of consolidation radiotherapy, which is often used to treat residual mediastinal masses.

For the future the role of FDG-PET scanning requires prospective examination, and it is hoped that this may allow the de-escalation of treatment if it can be shown to yield reliable prognostic information.

The relative rarity of this type of lymphoma necessitates international collaboration in clinical trials, with a prospective clinicopathologic study, IELSG 26, already underway.

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(PMID = 19074109.001).

[ISSN] 1520-4391

[Journal-full-title] Hematology. American Society of Hematology. Education Program

[ISO-abbreviation] Hematology Am Soc Hematol Educ Program

[Language] ENG

[Publication-type] Journal Article; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Radioisotopes; 0Z5B2CJX4D / Fluorodeoxyglucose F18

[Number-of-references] 77

   

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[Title] U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma.

Several patterns of association between Hodgkin and non-Hodgkin lymphomas are recognized, some of which support a common cellular origin or shared transformation events for both malignancies.

We describe the U-2940 cell line derived from a diffuse large B-cell lymphoma with some features consistent with mediastinal large B-cell lymphoma, clinically apparent 1 month after the initial course of chemotherapy for Hodgkin's disease, fulfilling the criteria for composite malignancies.

The cell line is negative for Epstein-Barr virus and no evidence of t(14;18) was found.

U-2940 cells display multiple chromosomal rearrangements similar to recurrent aberrations described in both Hodgkin and non-Hodgkin lymphomas, also partially shared by U-2932 derived from a B-cell lymphoma sequential to Hodgkin's disease.

The original large B-cell lymphoma and the U-2940 cell line bear microsatellite instability, an abnormality associated with particular subtypes of non-Hodgkin lymphomas and found in tissues involved by Hodgkin lymphoma.

Therefore, U-2940 cells bear several features known to occur in Hodgkin and in non-Hodgkin lymphomas, leading to the assumption that this cell line may constitute a useful tool to address elective pathways of lymphomagenesis and eventually the Hodgkin and non-Hodgkin lymphoma association.

[MeSH-major] Hodgkin Disease / pathology. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Second Primary / pathology

[MeSH-minor] Adolescent. Animals. Cell Line, Tumor. Chromosome Aberrations. Chromosomes, Human, Pair 14 / genetics. Chromosomes, Human, Pair 18 / genetics. Colony-Forming Units Assay. DNA, Neoplasm / analysis. Epstein-Barr Virus Infections / etiology. Epstein-Barr Virus Infections / pathology. Female. Gene Rearrangement. Herpesvirus 4, Human / pathogenicity. Humans. Immunoglobulin Heavy Chains / genetics. Mice. Mice, Nude. Spectral Karyotyping. Translocation, Genetic

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[Copyright] Copyright 2005 Wiley-Liss, Inc.

(PMID = 16106419.001).

[ISSN] 0020-7136

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Immunoglobulin Heavy Chains

   

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[Title] Primary mediastinal large B-cell lymphoma: a single-center study of clinicopathologic characteristics.

Primary mediastinal large B-cell lymphoma (PMLBCL) is a subset of LBCL with unique clinicopathologic features.

[MeSH-major] Lymphoma, B-Cell / blood. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / blood. Lymphoma, Large B-Cell, Diffuse / pathology. Mediastinal Neoplasms / blood. Mediastinal Neoplasms / pathology

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(PMID = 16757434.001).

[ISSN] 0925-5710

[Journal-full-title] International journal of hematology

[ISO-abbreviation] Int. J. Hematol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antigens, CD30; 0 / BCL6 protein, human; 0 / DNA-Binding Proteins; 0 / Proto-Oncogene Proteins c-bcl-6; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; EC 1.1.1.27 / L-Lactate Dehydrogenase; VB0R961HZT / Prednisone; CHOP protocol

   

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[Title] CNS recurrence of primary mediastinal large b-cell lymphoma after complete remission.

[MeSH-major] Lymphoma, Large B-Cell, Diffuse / pathology. Mediastinal Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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(PMID = 19381440.001).

[ISSN] 1573-7373

[Journal-full-title] Journal of neuro-oncology

[ISO-abbreviation] J. Neurooncol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Receptors, Complement 3d; EC 2.3.2.27 / MIB1 ligase, human; EC 2.3.2.27 / Ubiquitin-Protein Ligases

   

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[Title] Aberrant somatic hypermutation and expression of activation-induced cytidine deaminase mRNA in mediastinal large B-cell lymphoma.

To determine the possible role of aberrant somatic hypermutation (ASHM) and activation-induced cytidine deaminase (AID) expression in the pathogenesis of mediastinal large B-cell lymphoma (MBL), the mutational status of genes affected by ASHM, including c-MYC, PAX-5 and RhoH, was analysed, and the expression level of AID mRNA in tumour specimens from six patients with MBL was determined.

[MeSH-major] Cytidine Deaminase / genetics. Lymphoma, Large B-Cell, Diffuse / genetics. Mediastinal Neoplasms / genetics. Somatic Hypermutation, Immunoglobulin

[MeSH-minor] B-Cell-Specific Activator Protein. DNA Mutational Analysis. DNA, Neoplasm / genetics. DNA-Binding Proteins / genetics. Gene Expression. Genes, myc / genetics. Humans. Neoplasm Proteins / genetics. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Transcription Factors / genetics. rho GTP-Binding Proteins / genetics

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(PMID = 15842661.001).

[ISSN] 0007-1048

[Journal-full-title] British journal of haematology

[ISO-abbreviation] Br. J. Haematol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / B-Cell-Specific Activator Protein; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / Neoplasm Proteins; 0 / PAX5 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / RhoH protein, human; 0 / Transcription Factors; EC 3.5.4.5 / Cytidine Deaminase; EC 3.6.5.2 / rho GTP-Binding Proteins

   

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[Title] Mediastinal large B-cell lymphoma with rosette formation mimicking thymoma and thymic carcinoid.

[MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Mediastinal Neoplasms / diagnosis

[MeSH-minor] Adult. Carcinoid Tumor / diagnosis. Diagnosis, Differential. Female. Humans. Rosette Formation. Thymoma / diagnosis. Thymus Neoplasms / diagnosis

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(PMID = 16842255.001).

[ISSN] 0309-0167

[Journal-full-title] Histopathology

[ISO-abbreviation] Histopathology

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] England

   

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[Title] Identification and characterization of porcine mannan-binding lectin A (pMBL-A), and determination of serum concentration heritability.

Although two MBLs (MBL-A and MBL-C) have been characterized in various species, the identity of porcine MBL (pMBL) was not clearly defined.

Based on the N-terminal sequence, multiple sequence alignment, and relative affinities to various carbohydrate ligands, we propose that the MBL purified in this study is pMBL-A.

We have generated antibodies to this protein and established an immunoassay to quantify pMBL-A in serum.

Using this assay, we found breed differences in pMBL-A concentration distributions and heritability estimates.

In the Duroc breed (n=588), pMBL-A concentrations show a unimodal distribution with a mean of 9,125 ng/ml.

In contrast, the pMBL-A concentration distributions in the Landrace breed (n=533) show three distinct mean values: 301, 2,385, and 11,507 ng/ml.

Furthermore, heritability calculations based on an additive genetic variance model with no fixed effects indicate that serum pMBL-A concentration is highly heritable in the Landrace (h (2)=0.8) but not in the Duroc breed (h (2)=0.15).

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[Cites] J Biol Chem. 2004 Jul 30;279(31):32728-36 [15145932.001]

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(PMID = 16518621.001).

[ISSN] 0093-7711

[Journal-full-title] Immunogenetics

[ISO-abbreviation] Immunogenetics

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antibodies; 0 / Mannose-Binding Lectin; 0 / Monosaccharides

   

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The resulting atactic PMBL and PMMBL have high T(g)'s of 194 degrees C and 227 degrees C, respectively; when compared to atactic PMMA having comparable MW, the T(g) and onset decomposition temperatures of the PMMBL produced are substantially higher (by approximately 120 degrees C and 40 degrees C, respectively).

In comparison, the polymerizations by non-lanthanocene(III) silylamides, Ln[N(SiMe(3))(2)](3) (Ln = La, Nd, Sm, Er), and by cationic group 4 metallocene and half-metallocene catalysts incorporating C(2) and C(s) symmetric ligands are much slower and less effective.

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(PMID = 20631950.001).

[ISSN] 1477-9234

[Journal-full-title] Dalton transactions (Cambridge, England : 2003)

[ISO-abbreviation] Dalton Trans

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Primary cardiac non-Hodgkin's lymphoma diagnosed by transthoracic echocardiography.

Primary cardiac lymphomas are extremely rare and can be diagnosed by echocardiography.

We present the case of a 79-year-old man with an intracardiac mass, shown to be an aggressive large B-cell lymphoma by mediastinal aspiration, who had rapid regression of the tumor following one cycle of chemotherapy.

[MeSH-major] Heart Neoplasms / ultrasonography. Lymphoma, Non-Hodgkin / ultrasonography

[MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Humans. Male

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(PMID = 16445735.001).

[ISSN] 0742-2822

[Journal-full-title] Echocardiography (Mount Kisco, N.Y.)

[ISO-abbreviation] Echocardiography

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma.

The physiologic expression of the product of the proto-oncogene TCL1 (T-cell leukemia 1) is primarily restricted to early embryonic cells.

It has been shown that TCL1 is a powerful B-cell oncogene, which has been implicated in the pathogenesis of various types of mature B-cell lymphomas.

There is no comparative information in the literature addressing the expression of TCL1 in pediatric and adult nodal diffuse large B-cell lymphoma or primary mediastinal large B-cell lymphoma.

We studied 55 cases of adult and pediatric diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma to analyze the phenotypic profile of these lymphomas, including TCL1 expression, and its relationship with clinical outcome in different age groups.

TCL1 was observed in 11 cases, 5 pediatric and 6 adult cases, all but one diffuse large B-cell lymphoma.

TCL1 positivity was predominantly found in germinal center phenotype diffuse large B-cell lymphoma.

Primary mediastinal large B-cell lymphomas infrequently expressed TCL1 in both age groups.

[MeSH-major] Epstein-Barr Virus Infections / metabolism. Herpesvirus 4, Human / isolation & purification. Lymphoma, B-Cell / metabolism. Lymphoma, Large B-Cell, Diffuse / metabolism. Mediastinal Neoplasms / metabolism. Proto-Oncogene Proteins / metabolism

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[Copyright] Copyright 2010 Elsevier Inc. All rights reserved.

(PMID = 20382409.001).

[ISSN] 1532-8392

[Journal-full-title] Human pathology

[ISO-abbreviation] Hum. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / TCL1A protein, human

   

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[Title] Primary mediastinal large B-cell lymphoma: results of intensive chemotherapy regimens (MACOP-B/VACOP-B) plus involved field radiotherapy on 53 patients. A single institution experience.

PURPOSE: The optimal therapy for primary mediastinal large B-cell lymphoma (PMLBCL) remains undefined.

In the absence of randomized trials, we report clinical findings and treatment response in 53 consecutive patients treated with intensive chemotherapy and mediastinal involved-field radiation therapy (IFRT).

CONCLUSIONS: Our report confirms the efficacy of intensive chemotherapy plus mediastinal IFRT.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Lymphoma, B-Cell / mortality. Lymphoma, B-Cell / therapy. Neoplasm Recurrence, Local / mortality. Radiotherapy, Adjuvant / mortality

[MeSH-minor] Adolescent. Adult. Aged. Dose-Response Relationship, Drug. Female. Humans. Incidence. Italy / epidemiology. Male. Mediastinum. Middle Aged. Prognosis. Risk Assessment / methods. Risk Factors. Survival Analysis. Survival Rate. Treatment Outcome

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(PMID = 17379431.001).

[ISSN] 0360-3016

[Journal-full-title] International journal of radiation oncology, biology, physics

[ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.

[Language] eng

[Publication-type] Controlled Clinical Trial; Journal Article

[Publication-country] United States

   

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[Title] HLA-haploidentical nonmyeloablative stem cell transplantation: induction to tolerance without passing through mixed chimaerism.

There are few reports of unmanipulated HLA-haploidentical nonmyeloablative stem cell transplantation (NST) using only pharmacological acute graft-vs.-host disease (GVHD) prophylaxis.

We present here a successful case of unmanipulated HLA-haploidentical NST for mediastinal large B cell lymphoma that was resistant to autologous peripheral blood stem cell transplantation (PBSCT).

[MeSH-major] Hematopoietic Stem Cell Transplantation / methods. Histocompatibility Testing

[MeSH-minor] Adult. Female. Graft Survival. Graft vs Host Disease / prevention & control. Haplotypes. Humans. Immunosuppression / methods. Lymphoma, B-Cell / therapy. Mediastinal Neoplasms / therapy. Transplantation Chimera. Transplantation Conditioning / methods

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(PMID = 15784130.001).

[ISSN] 0141-9854

[Journal-full-title] Clinical and laboratory haematology

[ISO-abbreviation] Clin Lab Haematol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

   

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[Title] Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities.

In primary mediastinal large B-cell lymphoma and Hodgkin lymphoma (HL), inactivating mutations in SOCS1, an inhibitor of JAK/STAT signaling, contribute to deregulated STAT activity.

Based on indications that the SOCS1 mutations are caused by the B cell-specific somatic hypermutation (SHM) process, we analyzed B-cell non-HL and normal B cells for mutations in SOCS1.

One-fourth of diffuse large B-cell lymphoma and follicular lymphomas carried SOCS1 mutations, which were preferentially targeted to SHM hotspot motifs and frequently obviously inactivating.

Rare mutations were observed in Burkitt lymphoma, plasmacytoma, and mantle cell lymphoma but not in tumors of a non-B-cell origin.

Mutations in single-sorted germinal center B cells were infrequent relative to other genes mutated as byproducts of normal SHM, indicating that SOCS1 inactivation in primary mediastinal large B-cell lymphoma, HL, diffuse large B-cell lymphoma, and follicular lymphoma is frequently the result of aberrant SHM.

[MeSH-major] Lymphoma, B-Cell / genetics. Somatic Hypermutation, Immunoglobulin / genetics. Suppressor of Cytokine Signaling Proteins / genetics

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(PMID = 19734449.001).

[ISSN] 1528-0020

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / SOCS1 protein, human; 0 / Suppressor of Cytokine Signaling Proteins

   

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[Title] Relationship between classic Hodgkin lymphoma and overlapping large cell lymphoma investigated by comparative expressed sequence hybridization expression profiling.

There is a diagnostic grey zone between classic Hodgkin lymphoma (cHL) and some non-Hodgkin lymphoma (NHL), including primary mediastinal B cell lymphoma, diffuse large B cell lymphoma, and anaplastic large cell lymphoma.

To investigate this, we undertook an expression profiling study of these lymphomas using comparative expressed sequence hybridization.

Using this approach, we identified a unique expression profile for all lymphoma types investigated.

Moreover, anaplastic lymphoma kinase (ALK)-negative ALCL clustered in a separate branch together with ALCL-like HL.

Thus, analysing the neoplastic cells concurrently with their microenvironment, ALK-negative ALCL and ALCL-like HL seem to be related to each other, while cHL constitutes a separate lymphoma entity.

[MeSH-major] Hodgkin Disease / genetics. Lymphoma, Large B-Cell, Diffuse / genetics

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Cluster Analysis. DNA, Neoplasm / genetics. Diagnosis, Differential. Female. Gene Expression Profiling / methods. Humans. Male. Middle Aged. Neoplasm Staging. Nucleic Acid Hybridization / methods

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(PMID = 16874743.001).

[ISSN] 0022-3417

[Journal-full-title] The Journal of pathology

[ISO-abbreviation] J. Pathol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / DNA, Neoplasm

   

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[Title] Primary mediastinal large B-cell lymphoma: optimal therapy and prognostic factor analysis in 141 consecutive patients treated at Memorial Sloan Kettering from 1980 to 1999.

Primary mediastinal large B-cell lymphoma (PMLBL) is a distinct clinicopathological entity with unclear prognostic factors and optimal treatment approach.

Patients received cyclophosphamide, hydroxydaunomycin, Oncovin, prednisone (CHOP)-like therapy, the non-Hodgkin lymphoma (NHL)-15 regimen or upfront autologous stem cell transplantation (ASCT) on Institutional Review Board approved trials or according to the institutional guidelines.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Large B-Cell, Diffuse / drug therapy. Mediastinal Neoplasms / drug therapy

[MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Disease-Free Survival. Factor Analysis, Statistical. Female. Humans. Male. Middle Aged. Prognosis. Proportional Hazards Models. Stem Cell Transplantation. Survival Analysis. Transplantation, Autologous

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(PMID = 16115124.001).

[ISSN] 0007-1048

[Journal-full-title] British journal of haematology

[ISO-abbreviation] Br. J. Haematol.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / 5901CA05826-34

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] England

   

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[Title] Pathology of thymic tumors.

As the thymus is composed of heterogeneous admixture of lymphoid and epithelial elements, tumors originating in the thymus may be of varied histologic types.

Thymomas are the most common thymic tumor in adults.

In addition to histologic subtype, tumor stage and resection status are important factors in determining outcome in thymomas.

Thymic lymphomas typically occur in younger patients than thymomas.

The most common thymic lymphomas are precursor T-lymphoblastic lymphoma, Hodgkin lymphoma, and primary mediastinal large B-cell lymphoma.

Thorough histologic sampling and, in some cases, the appropriate use of ancillary studies such as immunohistochemistry, flow cytometry, and molecular studies, are important in proper pathologic evaluation of thymic tumors.

[MeSH-major] Carcinoma / pathology. Hodgkin Disease / pathology. Thymoma / pathology. Thymus Gland / pathology. Thymus Neoplasms / classification. Thymus Neoplasms / pathology

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(PMID = 16104355.001).

[ISSN] 1043-0679

[Journal-full-title] Seminars in thoracic and cardiovascular surgery

[ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Review

[Publication-country] United States

[Number-of-references] 69

   

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[Title] Primary mediastinal large cell lymphoma (PMBL): frontline treatment with autologous stem cell transplantation (ASCT). The GEL-TAMO experience.

Given the excellent results obtained with present new induction regimens in PMBL, the role of frontline ASCT is controversial.

We present 71 patients with PMBL receiving induction chemotherapy, followed by ASCT as frontline therapy from the GEL-TAMO registry.

With a median follow-up of 52.5 months, the OS, PFS and DFS at 4 years from diagnosis were, respectively, 84%, 81% and 81% for the first CR patients and 49%, 42% and 82% for the induction failure (PR and refractory) patients.

Our experience, with a prolonged follow-up, shows that patients with PMBL presenting at diagnosis with high-risk features or PR response to induction therapy have an encouraging survival with frontline ASCT.

[MeSH-major] Hematopoietic Stem Cell Transplantation. Lymphoma, Large B-Cell, Diffuse / therapy. Mediastinal Neoplasms / therapy

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[Copyright] Copyright (c) 2008 John Wiley & Sons, Ltd.

[CommentIn] Expert Rev Hematol. 2009 Feb;2(1):31-6 [21082992.001]

(PMID = 18432630.001).

[ISSN] 0278-0232

[Journal-full-title] Hematological oncology

[ISO-abbreviation] Hematol Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.

Primary mediastinal B-cell lymphoma (PMBL) is a separate entity of aggressive B-cell lymphoma, characterized by a constitutive activation of janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, also observed in Hodgkin lymphoma.

Here, we show that MedB-1 PMBL-derived and L1236 Hodgkin-derived cell lines and 20 of 55 (36%) PMBL cases harbor heterozygous missense mutations in STAT6 DNA binding domain, whereas no mutation was found in 25 diffuse large B-cell lymphoma samples.

The mutant STAT6 proteins showed a decreased DNA binding ability in transfected HEK cells, but no decrease in expression of STAT6 canonical target genes was observed in PMBL cases with a mutated STAT6 gene.

Although the oncogenic properties of STAT6 mutant proteins remain to be determined, their recurrent selection in PMBL strongly argues for their involvement in the pathogenesis of this aggressive B-cell lymphoma.

[MeSH-major] Gene Expression Regulation, Neoplastic / genetics. Lymphoma, Large B-Cell, Diffuse / genetics. Mediastinal Neoplasms / genetics. Mutation / genetics. Neoplasm Proteins / genetics. STAT6 Transcription Factor / genetics

[MeSH-minor] Cell Line, Tumor. Female. Humans. Male. Protein Structure, Tertiary / genetics. Signal Transduction / genetics

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[CommentIn] Blood. 2009 Aug 6;114(6):1133-4 [19661272.001]

(PMID = 19423726.001).

[ISSN] 1528-0020

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Neoplasm Proteins; 0 / STAT6 Transcription Factor; 0 / STAT6 protein, human

[Other-IDs] NLM/ HALMS411059; NLM/ PMC2824656

   

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[Title] [Primary mediastinal B-cell lymphoma].

[Transliterated title] Lymphomes B primitifs du médiastin: aspect clinique.

Primary mediastinal B-cell lymphoma (PMBL) is a clinicopathological entity among the world health organization classification of lymphoid neoplasms.

PMBL often concerns young adults, and the disease remains a localized disease in the majority of cases.

The outcome of patients with PMBL is variable and unlike diffuse large cell lymphomas, the international prognostic index seems to be less applicable to such disease.

However, high-dose chemotherapy supported by peripheral blood stem cell support is often warranted in poor-prognosis patients.

[MeSH-major] Lymphoma, B-Cell / diagnosis. Mediastinal Neoplasms / diagnosis

[MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Fluorodeoxyglucose F18. Hematopoietic Stem Cell Transplantation. Humans. Positron-Emission Tomography. Prognosis. Radiotherapy, Adjuvant. Rituximab. Young Adult

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[Copyright] Copyright (c) 2010. Published by Elsevier Masson SAS.

(PMID = 20207294.001).

[ISSN] 0761-8417

[Journal-full-title] Revue de pneumologie clinique

[ISO-abbreviation] Rev Pneumol Clin

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] France

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 4F4X42SYQ6 / Rituximab

[Number-of-references] 32

   

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The aim of the present trial is to evaluate the efficacy of the treatment with an immunostimulating vaccine consisting of a polyvalent mechanical bacterial lysate (PMBL) in the prophylaxis of allergic rhinitis and subsequently to analyze its in vivo effects on immune responses.

41 allergic rhinitis patients were enrolled: 26 patients were randomly assigned to the group for PMBL sublingual treatment and 15 others to the group for placebo treatment.

For all 26 patients blood samples were drawn just before (T0) and after 3 months of PMBL treatment (T3) to evaluate plasma IgE levels (total and allergen-specific) and the cytokine production involved in the allergic response (IL-4, IFN-gamma).

The results of our study indicate that PMBL is effective in vivo in the reduction or in the elimination of the symptoms in rhinitis subjects during the treatment period in comparison to a non-immunostimulating treatment.

PMBL treatment did not affect the serum IgE levels (either total or allergen-specific) and did not induce significant changes in IFN-gamma concentration.

In contrast, PMBL therapy may be accompanied, in some patients, by a potential immunomodulating activity by decreasing IL-4 cytokine expression.

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(PMID = 17346436.001).

[ISSN] 0394-6320

[Journal-full-title] International journal of immunopathology and pharmacology

[ISO-abbreviation] Int J Immunopathol Pharmacol

[Language] eng

[Publication-type] Journal Article; Randomized Controlled Trial

[Publication-country] England

[Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Bacterial Vaccines; 0 / Cytokines; 0 / RNA, Messenger; 207137-56-2 / Interleukin-4; 37341-29-0 / Immunoglobulin E

   

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[Title] STAT6 in PMBL: pathogenic or passenger?

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[CommentOn] Blood. 2009 Aug 6;114(6):1236-42 [19423726.001]

(PMID = 19661272.001).

[ISSN] 1528-0020

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Comment; Journal Article

[Publication-country] United States

   

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[Title] [Mediastinal large B-cell lymphoma].

[Transliterated title] Das mediastinale (thymische) grosszellige B-Zell-Lymphom.

Mediastinal B-cell lymphoma is a locally highly aggressive tumour which was first described in the early 1980s.

The incidence is about 2-3% of all non-Hodgkin's lymphomas.

The conceptional evolution of this lymphoma entity was hampered by its low incidence and the broad spectrum of morphological variants present.

However, since mediastinal B-cell lymphoma has distinct morphological, immunological, genetic, and clinical features, it has been listed in the revised European-American Classification of Lymphoid Neoplasms (REAL-Classification) since 1994 as a variant of diffuse large B-cell lymphoma.

In the World Health Organization classification of malignant lymphomas, mediastinal B-cell lymphoma is now listed with an own disease code (ICD-9679/3).

[MeSH-major] Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / pathology. Mediastinal Neoplasms / pathology

[MeSH-minor] Humans. Immunophenotyping. Incidence. Lymphoma, Non-Hodgkin / epidemiology. Lymphoma, Non-Hodgkin / pathology. Neoplasm Staging

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(PMID = 17195039.001).

[ISSN] 0172-8113

[Journal-full-title] Der Pathologe

[ISO-abbreviation] Pathologe

[Language] ger

[Publication-type] English Abstract; Journal Article

[Publication-country] Germany