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[Title] Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.

The ability of leukemia cells to accumulate methotrexate polyglutamate (MTXPG) is an important determinant of the antileukemic effects of methotrexate (MTX).

We measured in vivo MTXPG accumulation in leukemia cells from 101 children with acute lymphoblastic leukemia (ALL) and established that B-lineage ALL with either TEL-AML1 or E2A-PBX1 gene fusion, or T-lineage ALL, accumulates significantly lower MTXPG compared with B-lineage ALL without these genetic abnormalities or compared with hyperdiploid (fewer than 50 chromosomes) ALL.

To elucidate mechanisms underlying these differences in MTXPG accumulation, we used oligonucleotide microarrays to analyze expression of 32 folate pathway genes in diagnostic leukemia cells from 197 children.

These findings reveal distinct mechanisms of subtype-specific differences in MTXPG accumulation and point to new strategies to overcome these potential causes of treatment failure in childhood ALL.

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(PMID = 15630450.001).

[ISSN] 0021-9738

[Journal-full-title] The Journal of clinical investigation

[ISO-abbreviation] J. Clin. Invest.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA71907-07; United States / NCI NIH HHS / CA / R37 CA36401; United States / NCI NIH HHS / CA / P01 CA071907; United States / NIGMS NIH HHS / GM / U01 GM061393; United States / NCI NIH HHS / CA / R01 CA078224; United States / NCI NIH HHS / CA / R37 CA036401; United States / NCI NIH HHS / CA / CA21765; United States / NIGMS NIH HHS / GM / U01 GM61393; United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / R01 CA051001; United States / NCI NIH HHS / CA / R01 CA78224; United States / NCI NIH HHS / CA / R01 CA51001

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / RNA, Messenger; 25513-46-6 / Polyglutamic Acid; 82334-40-5 / methotrexate polyglutamate; 9007-49-2 / DNA; 935E97BOY8 / Folic Acid; EC 2.1.1.45 / Thymidylate Synthase; YL5FZ2Y5U1 / Methotrexate

[Other-IDs] NLM/ PMC539195

   

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[Title] Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study.

The biological behavior of childhood B-lineage acute lymphoblastic leukemia (B-ALL) is different from that of adults.

[MeSH-major] Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Gene Deletion. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics

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(PMID = 19837270.001).

[ISSN] 1873-4456

[Journal-full-title] Cancer genetics and cytogenetics

[ISO-abbreviation] Cancer Genet. Cytogenet.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / CDKN2B protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Oncogene Proteins, Fusion

   

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[Title] Reinduction platform for children with first marrow relapse of acute lymphoblastic Leukemia: A Children's Oncology Group Study[corrected].

PURPOSE: Treatment of childhood relapsed acute lymphoblastic leukemia (ALL) remains a significant challenge.

Five of seven patients with T-cell ALL (T-ALL) failed to achieve CR2.

CONCLUSION: The AALL01P2 regimen is a tolerable and active reinduction platform, suitable for testing in combination with novel agents in B-precursor ALL.

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[ErratumIn] J Clin Oncol. 2008 Oct 1;26(28): 4697.

(PMID = 18711187.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R21CA110344; United States / NCI NIH HHS / CA / U10 CA98543

[Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 04079A1RDZ / Cytarabine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; VB0R961HZT / Prednisone; ZRP63D75JW / Idarubicin

[Other-IDs] NLM/ PMC2654313

   

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[Title] Are survivors of acute lymphoblastic leukemia (ALL) at increased risk of cardiovascular disease?

Through a variety of different mechanisms, it appears that survivors of childhood acute lymphoblastic leukemia have an increased prevalence of several cardiovascular risk factors and thus are at increased risk for developing cardiovascular disease.

The aim of this paper is to describe the current understanding of particular risk factors, including obesity, physical inactivity, dyslipidemia, insulin resistance, and metabolic syndrome, that may contribute to cardiovascular disease in survivors of childhood ALL.

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[Copyright] (c) 2007 Wiley-Liss, Inc.

(PMID = 18064658.001).

[ISSN] 1545-5017

[Journal-full-title] Pediatric blood & cancer

[ISO-abbreviation] Pediatr Blood Cancer

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA100474-04; United States / NCI NIH HHS / CA / R01 CA100474; United States / NCI NIH HHS / CA / R01 CA100474-04; United States / NCI NIH HHS / CA / R01-CA-100474

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review

[Publication-country] United States

[Number-of-references] 57

   

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[Title] [The clinical significance of detecting minimal residual disease in acute childhood B-cell lymphoblastic leukemia with flow cytometry].

OBJECTIVE: Flow cytometry may be used to detect minimal residual disease (MRD) in acute lymphoblastic leukemia because leukemic cells often display aberrant phenotypes when compared to normal cells.

The investigators also aimed to study the value of the detection of MRD by flow cytometry in childhood B-ALL without effective antibody combinations.

METHODS: Thirty-six cases of childhood B-ALL with effective antibody combinations were performed MRD analysis after induction therapy.

(1) Forty-two cases of childhood B-ALL were screened for antibody combinations of interest and were identified in 86% (36/42) of the cases.

CONCLUSION:. (1) Flow cytometry is a sensitive and specific method for detecting MRD of childhood ALL, and could predict the coming relapse. (2) Patients with MRD levels > 10(-3) had poor prognosis. (3) The levels of MRD at month 9 and 12 had prognostic value. (4) The value of antibody combinations consisting of CD(45)/CD(19)/CD(10)/CD(34) and CD(45)/CD(19)/CD(20)/CD(22) should be further investigated in patients without effective antibody combinations.

[MeSH-major] B-Lymphocyte Subsets / immunology. Flow Cytometry. Immunophenotyping. Neoplasm, Residual / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis

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(PMID = 16083543.001).

[ISSN] 0578-1310

[Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics

[ISO-abbreviation] Zhonghua Er Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Evaluation Studies; Journal Article

[Publication-country] China

   

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It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcription, cell division, and cell activation.

Zinc deficiency has adverse consequences during embryogenesis and early childhood development, particularly on immune functioning.

Zinc depletion induces cell death via apoptosis (or necrosis if apoptotic pathways are blocked) while sufficient zinc levels allows maintenance of autophagy.

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(PMID = 21087493.001).

[ISSN] 1479-5876

[Journal-full-title] Journal of translational medicine

[ISO-abbreviation] J Transl Med

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / P01 CA 10944-04

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

[Publication-country] England

[Chemical-registry-number] J41CSQ7QDS / Zinc

[Other-IDs] NLM/ PMC3002329

   

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Epidemiological studies of IBS point to risk factors such as familial clustering, sexual abuse and other forms of childhood trauma, low birth weight and gastrointestinal infection.

Studies in animal models of early stress and in humans who have experienced childhood trauma or abuse suggest that these events can lead to long-lasting epigenetic changes in the glucocorticoid receptor gene brought about by hypermethylation of a key regulatory component.

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(PMID = 20585338.001).

[ISSN] 1759-5053

[Journal-full-title] Nature reviews. Gastroenterology & hepatology

[ISO-abbreviation] Nat Rev Gastroenterol Hepatol

[Language] eng

[Publication-type] Research Support, Non-U.S. Gov't; Review

[Publication-country] England

   

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[Title] Parental comprehension and satisfaction in informed consent in paediatric clinical trials: a prospective study on childhood leukaemia.

The authors included all parents whose consent was sought for their child to participate in the FRALLE 2000A protocol (acute lymphoblastic leukaemia) at two centres.

[MeSH-major] Health Knowledge, Attitudes, Practice. Informed Consent / psychology. Parents / psychology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Randomized Controlled Trials as Topic

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(PMID = 20551191.001).

[ISSN] 1468-2044

[Journal-full-title] Archives of disease in childhood

[ISO-abbreviation] Arch. Dis. Child.

[Language] eng

[Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] England

   

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[Title] Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes.

The hallmark of acute lymphoblastic leukemia (ALL) is a progressive appearance of malignant cell behavior that is triggered by the evolution of altered gene function.

The presence in individual tumors of multiple genes simultaneously methylated is an independent factor of poor prognosis in both childhood and adult ALL in terms of disease-free survival and overall survival.

[MeSH-major] DNA Methylation. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

Genetic Alliance. consumer health - Acute Lymphoblastic Leukemia.

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(PMID = 17613754.001).

[ISSN] 1042-8194

[Journal-full-title] Leukemia & lymphoma

[ISO-abbreviation] Leuk. Lymphoma

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] England

[Number-of-references] 100

   

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Participants in the Pittsburgh EDC Study, a prospective investigation of childhood-onset type 1 DM, who underwent 2 electron beam tomographic screenings 4 years apart were selected for study (n = 222).

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(PMID = 17996516.001).

[ISSN] 0002-9149

[Journal-full-title] The American journal of cardiology

[ISO-abbreviation] Am. J. Cardiol.

[Language] ENG

[Grant] United States / NIDDK NIH HHS / DK / DK034818-23S1; United States / NIDDK NIH HHS / DK / R01 DK034818-23S1; United States / NIDDK NIH HHS / DK / DK34818; United States / NIDDK NIH HHS / DK / R37 DK034818; United States / NIDDK NIH HHS / DK / R01 DK034818

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Cholesterol, HDL

[Other-IDs] NLM/ NIHMS34581; NLM/ PMC2206537

   

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Although cure rate of childhood acute lymphoblastic leukemia (ALL) has surpassed 80%, drug resistance remains a major cause of treatment failure.

Among these SNPs, the -228G>T SNP (allele frequency 9.4%) was the only one that significantly increased reporter activity in human ALL cell lines.

The -228G>T SNP altered SMARCB1 mRNA and protein levels and a positive association was found between the SMARCB1 mRNA level and both the -228 genotype and prednisolone sensitivity in CEPH cell lines.

Finally, knockdown experiments performed in human ALL cell lines confirmed that lower SMARCB1 expression increased prednisolone resistance.

[MeSH-minor] Amino Acid Sequence. Blotting, Western. Cell Line. Chromosome Mapping. Electrophoretic Mobility Shift Assay. Gene Frequency. Genotype. Humans. Lymphocytes / cytology. Lymphocytes / drug effects. Lymphocytes / metabolism. Molecular Sequence Data. Mutagenesis, Site-Directed. Polymorphism, Single Nucleotide. Prednisolone / pharmacology. Promoter Regions, Genetic / genetics. Protein Binding. RNA Interference. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Small Interfering / genetics. Sequence Alignment. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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(PMID = 17616514.001).

[ISSN] 0964-6906

[Journal-full-title] Human molecular genetics

[ISO-abbreviation] Hum. Mol. Genet.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / P30 CA21765; United States / NCI NIH HHS / CA / R01 CA51001; United States / NCI NIH HHS / CA / R01 CA78224; United States / NCI NIH HHS / CA / R37 CA36401; United States / NIGMS NIH HHS / GM / U01 GM61393; United States / NIGMS NIH HHS / GM / U01 GM61394

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / SMARCB1 protein, human; 0 / Steroids; 0 / Transcription Factors; 9PHQ9Y1OLM / Prednisolone; EC 2.4.2.30 / PARP1 protein, human; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases

   

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[Title] [Evaluation of the P-gp pump function on leukemic cell membrane and proper application of its reversal agents with Calcein-AM and flow cytometry].

OBJECTIVE: Leukemia is the most common malignancy in children.

During the past decade, very high cure rates of childhood acute lymphoblastic leukemia (ALL) have been reported both at home and abroad.

However, the cure rates of children with acute myeloid leukemia (AML) remain low due to the multiple-drug resistance (MDR).

P-glycoprotein (P-gp) is one of the most important mechanisms of MDR for leukemia cells.

The present study aimed to evaluate the P-gp pump function on leukemia cell membrane and the effects of the combined administration of the reversal agents cyclosporin A (CSA) and verapamil (VER) through the observation of Calcein-AM (C-AM) metabolism in the cell line K562 and its multi-drug resistant subline K562/VCR.

On the other hand, significant inhibition of the efflux from the K562/VCR cell line was also noticed after the same time period of incubation with the MFIs of 2237 +/- 155, 1932 +/- 233 and 2231 +/- 147, respectively in the three groups, which was significantly higher than that of control group (1622 +/- 191, P < 0.05).

CSA, VER and CSA + VER could increase the uptake and inhibit the efflux of C-AM by K562/VCR cells, while no evident influence on those functions inside the parental cell line K562 cells was noticed.

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(PMID = 17697617.001).

[ISSN] 0578-1310

[Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics

[ISO-abbreviation] Zhonghua Er Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Fluoresceins; 0 / P-Glycoprotein; 148504-34-1 / calcein AM; 5J49Q6B70F / Vincristine; CJ0O37KU29 / Verapamil; V0YM2B16TS / fluorexon

   

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[Title] [Evaluation of a modified induction chemotherapy in children with acute lymphoblastic leukemia].

OBJECTIVE: To improve the treatment outcome of children with acute lymphoblastic leukemia (ALL), and to evaluate the efficacy and safety of a modified induction chemotherapy between the two protocols used to treat children with ALL in Shanghai Children's Medical Center.

1st, 2006, 311 patients with newly diagnosed childhood ALL, who underwent induction chemotherapy for over 10 days, were eligible for analysis.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Lymphoid / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Remission Induction / methods

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(PMID = 17697614.001).

[ISSN] 0578-1310

[Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics

[ISO-abbreviation] Zhonghua Er Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article; Meta-Analysis

[Publication-country] China

   

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[Title] Immunosurveillance of childhood ALL: polymorphic interferon-gamma alleles are associated with age at diagnosis and clinical risk groups.

To determine whether a CA-repeat associated with differential NFkappaB-binding and IFN-gamma-expression levels may influence the incidence, manifestation and early clinical treatment response of childhood acute lymphoblastic leukemia, we performed PCR-based genotyping of 393 patients with ALL and 207 healthy controls.

[MeSH-major] Interferon-gamma / genetics. Polymorphism, Genetic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology

[MeSH-minor] Cell Lineage. Child. Child, Preschool. Female. Humans. Infant. Male. Risk Factors

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(PMID = 15496974.001).

[ISSN] 0887-6924

[Journal-full-title] Leukemia

[ISO-abbreviation] Leukemia

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 82115-62-6 / Interferon-gamma

   

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[Title] Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group study CCG 1922.

PURPOSE: To compare outcomes of patients with NCI standard risk acute lymphoblastic leukemia (ALL) who relapsed after being randomized to receive either oral or intravenous 6-mercaptopurine (6MP) in the Children's Cancer Group study CCG 1922.

CONCLUSION: Treatment with intravenous 6MP during a brief period of total therapy had a significant negative impact on the prognosis in childhood ALL even though oral 6MP was used during maintenance.

[MeSH-major] 6-Mercaptopurine / administration & dosage. Antimetabolites, Antineoplastic / administration & dosage. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Salvage Therapy

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[CommentIn] Pediatr Blood Cancer. 2006 May 1;46(5):660-1 [16276523.001]

[CommentIn] Pediatr Blood Cancer. 2005 Jul;45(1):2-4 [15706584.001]

(PMID = 15481062.001).

[ISSN] 1545-5009

[Journal-full-title] Pediatric blood & cancer

[ISO-abbreviation] Pediatr Blood Cancer

[Language] eng

[Grant] United States / NCI NIH HHS / CA / CA-13539

[Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; E7WED276I5 / 6-Mercaptopurine

   

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[Title] DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is the most common cancer in children in the modern world.

A number of DNA methylation and miRNA profiling studies have investigated the role of both in childhood ALL.

[MeSH-major] DNA Methylation / physiology. Epigenesis, Genetic / physiology. High-Throughput Screening Assays / methods. MicroRNAs / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology

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(PMID = 22122053.001).

[ISSN] 1750-192X

[Journal-full-title] Epigenomics

[ISO-abbreviation] Epigenomics

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MicroRNAs

   

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[Title] Establishment of testicular endocrine function impairment during childhood and puberty in boys with Klinefelter syndrome.

OBJECTIVE: To precisely characterize the chronology of testicular endocrine function impairment during childhood and adolescence in patients with Klinefelter syndrome.

However, levels of the inhibin alpha-subunit precursor Pro-alphaC were in the lowest levels of the normal range in most cases.

CONCLUSIONS: In Klinefelter syndrome, a mild Leydig cell dysfunction is present from early childhood in most cases and persists throughout puberty.

Sertoli cell function is normal until mid puberty, when a dramatic impairment is observed.

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(PMID = 17645574.001).

[ISSN] 1365-2265

[Journal-full-title] Clinical endocrinology

[ISO-abbreviation] Clin. Endocrinol. (Oxf)

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Protein Precursors; 0 / inhibin B; 0 / inhibin-alpha subunit precursor; 3XMK78S47O / Testosterone; 57285-09-3 / Inhibins; 80497-65-0 / Anti-Mullerian Hormone; 9002-67-9 / Luteinizing Hormone

   

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With this new definition the disease spectrum has broadened and ranges from intrauterine growth retardation, cerebellar hypoplasia, and death in early childhood to asymptomatic mutation carriers whose descendants are predisposed to malignancy, BMF, or pulmonary disease.

[MeSH-minor] Adult. Aged. Aging / physiology. Bone Marrow / pathology. Cell Division / genetics. Genetic Diseases, Inborn / enzymology. Genetic Diseases, Inborn / genetics. Humans. Infant, Newborn. Middle Aged. Mutation. Neoplasms / epidemiology. Neoplasms / genetics. Telomerase / genetics. Telomerase / metabolism. Telomere-Binding Proteins / genetics

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[Copyright] Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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(PMID = 20493861.001).

[ISSN] 1873-3468

[Journal-full-title] FEBS letters

[ISO-abbreviation] FEBS Lett.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / R01 CA105312; United States / NCI NIH HHS / CA / R01 CA106995; United States / NCI NIH HHS / CA / R01 CA106995; United States / NCI NIH HHS / CA / R01 CA106995-07

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Telomere-Binding Proteins; 0 / shelterin, human; EC 2.7.7.49 / Telomerase

[Other-IDs] NLM/ NIHMS300709; NLM/ PMC3238451

   

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[Title] Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced.

The TFPT/FB1 gene was identified because of its involvement in childhood pre-B acute lymphoblastic leukaemia (ALL).

Although its specific function is still unclear, Tfpt has been implicated in cell proliferation and induction of programmed cell death (PCD).

Given the critical role of PCD in leukemogenesis, we have investigated the responsiveness of different cell lines to TFPT over expression and the consequent induction of PCD by proliferation kinetic analysis, immunolocalization and TUNEL assay.

We have also tested the involvement of factors implicated in cell cycle progression and apoptosis, i.e. caspases, p53, Cdc2.

Our results indicate that over expression of TFPT promotes caspase 9-dependent apoptosis, nevertheless the apoptotic cascade is engaged only in culture conditions sustaining cell proliferation and different cell lines display differential responsiveness to TFPT induced apoptosis Although p53 is a main regulator of apoptosis in mammalian cells, the Tfpt induced apoptosis appears p53-independent.

[MeSH-minor] Animals. Caspases / metabolism. Cell Count. Cell Proliferation. Enzyme Activation. Gene Expression. HeLa Cells. Humans. In Situ Nick-End Labeling. Kinetics. Mice. Models, Biological. NIH 3T3 Cells. Protein Binding. Transcription Factor 7-Like 1 Protein

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(PMID = 17041757.001).

[ISSN] 1360-8185

[Journal-full-title] Apoptosis : an international journal on programmed cell death

[ISO-abbreviation] Apoptosis

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / TCF Transcription Factors; 0 / TCF7L1 protein, human; 0 / TFPT protein, human; 0 / TFPT protein, mouse; 0 / Tcf7l1 protein, mouse; 0 / Transcription Factor 7-Like 1 Protein; 0 / Tumor Suppressor Protein p53; EC 3.4.22.- / Caspases

   

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[Title] Simultaneous assessment of p53 and MDM2 expression in leukemic cells in response to initial prednisone therapy in children with acute lymphoblastic leukemia.

Ineffective apoptosis is one of main causes of a treatment failure in childhood acute lymphoblastic leukemia (ALL).

[MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Leukocytes, Mononuclear / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism. Prednisone / therapeutic use. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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(PMID = 21290342.001).

[ISSN] 1233-9687

[Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists

[ISO-abbreviation] Pol J Pathol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Poland

[Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2; VB0R961HZT / Prednisone

   

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The leukemic cells were collected from 78 childhood leukemia patients admitted at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand, in the period from July 2003 to February 2005.

There were 61 cases of acute lymphoblastic leukemia (ALL), 14 cases of acute myeloblastic leukemia (AML), and 3 cases of chronic myelocytic leukemia (CML).

Thus, curcumin treatment may provide a lead for clinical treatment of leukemia patients in the future.

[MeSH-minor] Acute Disease. Adolescent. Age Factors. Antineoplastic Agents / chemistry. Antineoplastic Agents / pharmacology. Bone Marrow / drug effects. Bone Marrow / metabolism. Bone Marrow / pathology. Cell Survival / drug effects. Child, Preschool. Female. Humans. Infant. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Leukemia, Myeloid / blood. Leukemia, Myeloid / genetics. Leukemia, Myeloid / pathology. Male. Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. RNA, Messenger / genetics. RNA, Messenger / isolation & purification. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Tumor Cells, Cultured

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(PMID = 17121181.001).

[ISSN] 0253-6269

[Journal-full-title] Archives of pharmacal research

[ISO-abbreviation] Arch. Pharm. Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Korea (South)

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / RNA, Messenger; IT942ZTH98 / Curcumin

   

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[Title] XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL.

BACKGROUND: Resistance to glucocorticoid induced apoptosis is one of the major risk factors for relapse and poor outcome in childhood acute lymphoblastic leukemia (ALL).

PROCEDURE: XIAP protein and mRNA expression were determined in leukemic blasts of 51 childhood ALL patients and normal bone marrow mononuclear cells.

RESULTS: XIAP protein but not mRNA expression was found to be highly increased in childhood ALL compared to control bone marrow mononuclear cells (MNC) (median: 3.5 vs. 0.14 ng/10(5) MNC, P < 0.0001) indicating a post-transcriptional regulation of XIAP expression.

In patients with T-cell ALL, poor prednisone response was associated with increased XIAP expression (median: 2.8 in good vs. 5.8 in poor responders; P = 0.005).

Similarly, T-cell ALL patients suffering adverse events showed higher initial XIAP levels than patients in continuous complete remission (CCR) (median: 2.7 in patients in CCR vs. 5.6 in patients suffering adverse events; P = 0.007).

CONCLUSION: In childhood ALL compared to control bone marrow, the expression of the apoptosis inhibitor XIAP is highly increased by post-transcriptional regulation.

The association with poor in vivo glucocorticoid response and outcome in T-cell ALL suggests XIAP inhibition as a promising novel approach for the treatment of resistant ALL.

[MeSH-major] Gene Expression Regulation, Leukemic. Glucocorticoids / pharmacology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. X-Linked Inhibitor of Apoptosis Protein / genetics

[MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / pharmacology. Bone Marrow Cells / pathology. Bone Marrow Examination. Child. Drug Resistance. Female. Humans. Leukemia-Lymphoma, Adult T-Cell / drug therapy. Male. Monocytes / pathology. Pharmacogenetics. Prognosis. RNA, Messenger / analysis. Treatment Outcome. Up-Regulation

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[Copyright] (c) 2010 Wiley-Liss, Inc.

(PMID = 20582956.001).

[ISSN] 1545-5017

[Journal-full-title] Pediatric blood & cancer

[ISO-abbreviation] Pediatr Blood Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Glucocorticoids; 0 / RNA, Messenger; 0 / X-Linked Inhibitor of Apoptosis Protein

   

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[Title] Birth weight, maternal weight and childhood leukaemia.

There is mounting evidence that childhood leukaemia is associated with high birth weight, but few studies have examined the relationship between leukaemia and other perinatal factors that influence birth weight, such as maternal weight or gestational weight gain.

This case-cohort study included 916 acute lymphocytic leukaemia (ALL) and 154 acute myeloid leukaemia (AML) cases diagnosed prior to age 10 years between 1985 and 2001 and born in New York State excluding New York City between 1978 and 2001.

These findings suggest childhood leukaemia may be related to factors influencing abnormal fetal growth patterns.

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(PMID = 16736025.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] ENG

[Grant] United States / PHS HHS / / U55/CCU222012-03

[Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.

[Publication-country] England

[Other-IDs] NLM/ PMC2361297

   

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[Title] Analysis of human T-cell lymphotropic virus in CD25+ anaplastic large cell lymphoma in children.

Anaplastic large cell lymphoma (ALCL) is recognized as 2 distinct diseases: anaplastic lymphoma kinase (ALK)+ ALCL and ALK- ALCL.

Human T-cell lymphotropic virus (HTLV-1) is linked to the development of adult T-cell leukemia/lymphoma (ATLL), which frequently expresses CD25.

CD25 is significantly expressed in childhood ALCL.

We analyzed 33 cases of pediatric ALCL, CD25+ and CD25-, for proviral HTLV-1 DNA.

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(PMID = 19864230.001).

[ISSN] 1943-7722

[Journal-full-title] American journal of clinical pathology

[ISO-abbreviation] Am. J. Clin. Pathol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA112217-03; United States / NCI NIH HHS / CA / CA121935-03; United States / NCI NIH HHS / CA / R01 CA112217-03; United States / NCI NIH HHS / CA / R01 CA082274-08; United States / NCI NIH HHS / CA / R01 CA082274; United States / NCI NIH HHS / CA / R01 CA121935-03; United States / NCI NIH HHS / CA / R01 CA121935

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] England

[Chemical-registry-number] 0 / DNA, Viral; 0 / IL2RA protein, human; 0 / Interleukin-2 Receptor alpha Subunit; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase

[Other-IDs] NLM/ NIHMS125676; NLM/ PMC2771325

   

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Nevertheless, it significantly reduces the risk of severe childhood tuberculosis and continues to be used to prevent tuberculosis in many countries.

CD3+, CD4+ and CD8+ cell counts were measured by Flow cytometry. r32kDaBCG (Ag85A-BCG) protein was used to stimulate T cells in in vitro T cell responses and interferon-gamma (IFN-gamma) cytokine levels in the supernatants were measured by ELISA.

T cell subsets were within the normal range in all subjects.

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(PMID = 17555578.001).

[ISSN] 1476-8518

[Journal-full-title] Journal of immune based therapies and vaccines

[ISO-abbreviation] J Immune Based Ther Vaccines

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC1899498

   

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[Title] Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia.

A major issue in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) is resistance to chemotherapeutic drugs.

[MeSH-major] ATP-Binding Cassette Transporters / genetics. Drug Resistance, Neoplasm / genetics. Leukemia-Lymphoma, Adult T-Cell / genetics

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(PMID = 16928819.001).

[ISSN] 1535-7163

[Journal-full-title] Molecular cancer therapeutics

[ISO-abbreviation] Mol. Cancer Ther.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / ABCA2 protein, human; 0 / ABCA3 protein, human; 0 / ATP-Binding Cassette Transporters; 0 / Antineoplastic Agents; 0 / Multidrug Resistance-Associated Proteins

   

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[Title] Childhood hematopoietic malignancies and parental use of tobacco and alcohol: the ESCALE study (SFCE).

OBJECTIVES: Investigating the role of parental smoking and maternal alcohol consumption in the etiology of childhood hematopoietic malignancies.

RESULTS: A total of 765 cases of acute leukemia (AL), 130 of Hodgkin's lymphoma (HL), 165 of non-Hodgkin's lymphoma (NHL) and 1681 controls were included.

Paternal smoking was significantly associated with childhood ALL (OR = 1.4 [1.1-1.7]), AML (OR = 1.5 [1.0-2.3]), Burkitt (OR = 2.0 [1.2-3.2]), and anaplastic large cell (OR = 3.2 [1.2-9.1]) NHL.

CONCLUSION: The results support the hypothesis that only paternal smoking, and not maternal alcohol consumption or cigarette smoking, plays a role in childhood hematopoietic malignancies.

[MeSH-minor] Burkitt Lymphoma / epidemiology. Burkitt Lymphoma / pathology. Case-Control Studies. Child. Child, Preschool. Female. France / epidemiology. Hodgkin Disease / epidemiology. Hodgkin Disease / pathology. Humans. Incidence. Leukemia, Myeloid, Acute / epidemiology. Leukemia, Myeloid, Acute / pathology. Logistic Models. Lymphoma, Non-Hodgkin / epidemiology. Lymphoma, Non-Hodgkin / pathology. Male. Maternal Exposure / adverse effects. Odds Ratio. Paternal Exposure / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Pregnancy. Registries / statistics & numerical data. Surveys and Questionnaires

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(PMID = 18618277.001).

[ISSN] 1573-7225

[Journal-full-title] Cancer causes & control : CCC

[ISO-abbreviation] Cancer Causes Control

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

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[Title] Rearrangements of IgH, TCRD and TCRG genes as clonality marker of childhood acute lymphoblastic leukemia.

AIM: Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements are excellent patient-specific targets for clonality studies and monitoring of acute lymphoblastic leukemia (ALL).

RESULTS: TCRD gene rearrangements were detected in 64%, TCRG - in 45%, and IgH - in 79% of B-precursor ALL patients.

The highest incidence of oligoclonal rearrangements - 25% was shown for IgH gene in patients with B-precursor ALL.

Seven pair cases of patients with de novo leukemia and relapses were analyzed and revealed subclonal deviation in rearrangements of IgH or TCR genes during disease evolution.

CONCLUSION: We propose a panel of 13 types of rearrangements (primer pairs) sufficient for tumor cell clonality detection in 96% of patients with ALL.

[MeSH-major] Gene Rearrangement, B-Lymphocyte, Heavy Chain. Gene Rearrangement, delta-Chain T-Cell Antigen Receptor. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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(PMID = 16404354.001).

[ISSN] 1812-9269

[Journal-full-title] Experimental oncology

[ISO-abbreviation] Exp. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Ukraine

[Chemical-registry-number] 0 / DNA Primers

   

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[Title] Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccine.

The induction of persistent protective levels of pathogen-specific antibody is an important goal of immunization against childhood infections.

An essential prelude to larger studies of peripheral blood B cells is an understanding of B-cell kinetics following immunization.

We measured MenC- and diphtheria-specific plasma and memory B-cell kinetics in infants receiving a CRM(197) (cross-reactive material; mutant diphtheria toxoid)-conjugated MenC vaccine at 2, 3 and 4 months of age.

Plasma cell responses were more delayed after the first dose when compared with the rapid appearance of plasma cells after the third dose.

This study provides data on B-cell kinetics following a primary schedule of immunization in young infants upon which to base further studies of the underlying cellular mechanism of humoral immunity.

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[ErratumIn] Immunology. 2011 Apr;132(4):589

(PMID = 19175802.001).

[ISSN] 1365-2567

[Journal-full-title] Immunology

[ISO-abbreviation] Immunology

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Bacterial Proteins; 0 / Meningococcal Vaccines; 0 / Vaccines, Conjugate; 0 / serogroup C meningococcal conjugate vaccine; 08VC9WC084 / CRM197 (non-toxic variant of diphtheria toxin)

[Other-IDs] NLM/ PMC2678189

   

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Because the symptoms of BPD in children are different from the typical symptoms in adulthood and have significant overlap with other childhood psychiatric disorders, this disorder is notoriously difficult to diagnose.

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(PMID = 16738246.001).

[ISSN] 1529-2401

[Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience

[ISO-abbreviation] J. Neurosci.

[Language] ENG

[Grant] United States / NIMH NIH HHS / MH / R01 MH063266; United States / NIMH NIH HHS / MH / MH63266; United States / NIMH NIH HHS / MH / R01 MH074000-01A1; United States / NIMH NIH HHS / MH / R01 MH074000; United States / NIMH NIH HHS / MH / MH074000-01A1

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 63231-63-0 / RNA; 9FN79X2M3F / Lithium

[Other-IDs] NLM/ NIHMS197434; NLM/ PMC4205587

   

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[Title] Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia.

FLT3 mutations are occasionally observed in acute lymphoblastic leukemia (ALL).

This study investigated the incidence of FLT3 mutations in 86 pediatric patients diagnosed with ALL and the co-presence of common RAS mutations.

[MeSH-major] Mutation / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. fms-Like Tyrosine Kinase 3 / genetics

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(PMID = 19085113.001).

[ISSN] 1559-131X

[Journal-full-title] Medical oncology (Northwood, London, England)

[ISO-abbreviation] Med. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] EC 2.7.10.1 / FLT3 protein, human; EC 2.7.10.1 / fms-Like Tyrosine Kinase 3

   

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[Title] [Research on the pharmacokinetics and pharmacodynamics of L-asparaginase during its treatment of childhood acute lymphoblastic leukemia].

OBJECTIVE: To investigate the changes in the activity of Escherichia coli asparaginase (L-asp) and the concentration of asparagines (ASN) in the plasma of the acute lymphoblastic leukemia (ALL) children receiving L-asp containing chemotherapeutic protocol to explore more reasonable usage of L-asp in the treatment of childhood ALL.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics. Asparaginase / pharmacokinetics. Asparagine / blood. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

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(PMID = 15921627.001).

[ISSN] 0253-2727

[Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

[ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 7006-34-0 / Asparagine; EC 3.5.1.1 / Asparaginase

   

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[Title] TEL/AML 1 real-time quantitative reverse transcriptase PCR can complement minimal residual disease assessment in childhood ALL.

[MeSH-major] Neoplasm, Residual / diagnosis. Oncogene Proteins, Fusion / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Reverse Transcriptase Polymerase Chain Reaction / methods

[MeSH-minor] Child. Core Binding Factor Alpha 2 Subunit. Humans. Immunoglobulins / genetics. Prospective Studies. Receptors, Antigen, T-Cell / genetics

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(PMID = 15858617.001).

[ISSN] 0887-6924

[Journal-full-title] Leukemia

[ISO-abbreviation] Leukemia

[Language] eng

[Publication-type] Comparative Study; Letter; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / Immunoglobulins; 0 / Oncogene Proteins, Fusion; 0 / Receptors, Antigen, T-Cell; 0 / TEL-AML1 fusion protein

   

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Investigation of these rodent models should complement the research from pediatric cohort studies and begin to bring us closer to understanding the role of viral respiratory tract infections in the inception of childhood asthma.

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[Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.

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(PMID = 21029934.001).

[ISSN] 1557-8607

[Journal-full-title] Immunology and allergy clinics of North America

[ISO-abbreviation] Immunol Allergy Clin North Am

[Language] ENG

[Grant] United States / NHLBI NIH HHS / HL / R01 HL097134; United States / NIAID NIH HHS / AI / U19 AI070503; United States / NIAID NIH HHS / AI / AI070503; United States / NHLBI NIH HHS / HL / HL097134

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review

[Publication-country] United States

[Other-IDs] NLM/ NIHMS227372; NLM/ PMC2966841

   

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[Title] ZAP-70 is highly expressed in most cases of childhood pre-B cell acute lymphoblastic leukemia.

ZAP-70 is, however, expressed in adult B cell chronic lymphocytic leukemia where it correlates with a poor prognosis.

We wished to determine if ZAP-70 is also expressed in pediatric B cell malignancy.

A quantitative PCR assay for ZAP-70 expression was established and ZAP-70 expression in a range of human B cell lines was compared with expression in the Jurkat T cell line.

ZAP-70 expression was then determined in bone marrow lymphoblasts obtained from 12 patients with pre-B cell acute lymphoblastic leukemia (ALL).

ZAP-70 expression was not detected in mature B cell lines but was detected in pre-B cell lines at a level comparable to that seen in T cells.

ZAP-70 expression was strongly expressed in nine of the 12 cases of primary pre-B cell lymphoblastic leukemia.

The T cell-associated protein kinase ZAP-70 is highly expressed in pre-B lineage cells and most cases of pre-B acute lymphoblastic leukemia.

ZAP-70 expression may hold prognostic value for pre-B ALL and raises the prospect of a novel therapeutic target.

[MeSH-major] B-Lymphocytes / metabolism. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / metabolism. Precursor Cells, B-Lymphoid / metabolism. ZAP-70 Protein-Tyrosine Kinase / metabolism

[MeSH-minor] Adolescent. Blotting, Western. Bone Marrow Cells / metabolism. Cell Line, Transformed. Cell Line, Tumor. Child. Child, Preschool. Female. Flow Cytometry. Gene Expression. Humans. Jurkat Cells. Male. Polymerase Chain Reaction

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(PMID = 18333847.001).

[ISSN] 1751-5521

[Journal-full-title] International journal of laboratory hematology

[ISO-abbreviation] Int J Lab Hematol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] EC 2.7.10.2 / ZAP-70 Protein-Tyrosine Kinase; EC 2.7.10.2 / ZAP70 protein, human

   

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[Title] Anteromedial plantar nodules of the heel in childhood: a variant of the normality?

Sonography showed an accumulation of tissue similar to subcutaneous cell tissue, compatible with fat.

MRI was performed in one case, showing an accumulation of fatty tissue similar to subcutaneous cell tissue.

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(PMID = 19741551.001).

[ISSN] 1473-5865

[Journal-full-title] Journal of pediatric orthopedics. Part B

[ISO-abbreviation] J Pediatr Orthop B

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Childhood vulval lichen sclerosus: autoimmunity to the basement membrane zone protein BP180 and its relationship to autoimmunity.

In adult women, there are antibody and T-cell responses to proteins in the basement membrane zone (BMZ).

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(PMID = 20456392.001).

[ISSN] 1365-2230

[Journal-full-title] Clinical and experimental dermatology

[ISO-abbreviation] Clin. Exp. Dermatol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Autoantibodies; 0 / Autoantigens; 0 / Immunoglobulin A; 0 / Immunoglobulin G; 0 / Non-Fibrillar Collagens; 0 / collagen type XVII

   

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Malignant tumors account for 1% of childhood cancers.

Assessment of potential for preservation of fertility should thus be a systematic element of care for children treated for a malignant tumor (high-dose chemotherapy with alkylizing agents, radiation therapy including the gonads) or those receiving hematopoietic stem cell grafts for malignant or benign disease (sickle-cell anemia, immune deficit).

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[Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.

(PMID = 20362960.001).

[ISSN] 0003-4266

[Journal-full-title] Annales d'endocrinologie

[ISO-abbreviation] Ann. Endocrinol. (Paris)

[Language] fre

[Publication-type] English Abstract; Journal Article

[Publication-country] France

   

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[Title] Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members.

BACKGROUND AND OBJECTIVES: The mechanism of glucocorticoid -induced apoptosis is not fully understood and early predictive assays based on apoptotic markers for clinical outcome in acute lymphoblastic leukemia (ALL) are scarce.

DESIGN AND METHODS: Primary childhood ALL samples, the pre-B ALL cell line RS(4;11), and the T-ALL cell line CCRF-CEM were used.

Inhibition of caspase activity did not, however, protect against Dex-induced Bak/Bax activation, loss of Delta psi m or cell death.

INTERPRETATION AND CONCLUSIONS: The differential regulation of pro- and anti-apoptotic Bcl-2 family members appears to be a key event in the execution of Dex-induced apoptosis in ALL cell lines, and also indicates a role for these proteins in primary ALL cells.

[MeSH-major] Apoptosis / drug effects. Dexamethasone / pharmacology. Gene Expression Regulation, Neoplastic. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Proto-Oncogene Proteins c-bcl-2 / genetics

[MeSH-minor] Apoptosis Regulatory Proteins / genetics. Caspases / metabolism. Cell Line, Tumor. Flow Cytometry. Humans. Tumor Cells, Cultured

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(PMID = 18024393.001).

[ISSN] 1592-8721

[Journal-full-title] Haematologica

[ISO-abbreviation] Haematologica

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Italy

[Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 7S5I7G3JQL / Dexamethasone; EC 3.4.22.- / Caspases