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29. Kenemans P, Kubista E, Foidart JM, Yip CH, von Schoultz B, Sismondi P, Vassilopoulou-Sellin R, Beckmann MW, Bundred NJ, Egberts J, van Os S, Planellas J: Safety of tibolone in the treatment of vasomotor symptoms in breast cancer patients--design and baseline data 'LIBERATE' trial. Breast; 2007 Dec;16 Suppl 2:S182-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • For the primary tumor, Stage IIA or higher was reported for >70% of the patients.
  • [MeSH-major] Antineoplastic Agents, Hormonal / pharmacology. Autonomic Nervous System Diseases / drug therapy. Breast Neoplasms / drug therapy. Norpregnenes / pharmacology. Vasomotor System / drug effects
  • [MeSH-minor] Aromatase Inhibitors / adverse effects. Aromatase Inhibitors / pharmacology. Aromatase Inhibitors / therapeutic use. Bone Density. Double-Blind Method. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Quality of Life. Survival Analysis. Tamoxifen / adverse effects. Tamoxifen / pharmacology. Tamoxifen / therapeutic use. Treatment Outcome

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  • [ErratumIn] Breast. 2008 Apr;17(2):214-5. Egberts, J [added]; van Os, S [added]; Planellas, J [added]
  • (PMID = 17983942.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Aromatase Inhibitors; 0 / Norpregnenes; 094ZI81Y45 / Tamoxifen; FF9X0205V2 / tibolone
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30. Rich T, Innominato PF, Boerner J, Mormont MC, Iacobelli S, Baron B, Jasmin C, Lévi F: Elevated serum cytokines correlated with altered behavior, serum cortisol rhythm, and dampened 24-hour rest-activity patterns in patients with metastatic colorectal cancer. Clin Cancer Res; 2005 Mar 1;11(5):1757-64
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  • Actigraphy patterns were correlated with QOL indices, serum cortisol obtained at 8:00 a.m. and 4:00 p.m. and with serum levels of transforming growth factor-alpha, tumor necrosis factor-alpha, and interleukin 6 (IL-6) obtained at 8:00 a.m. and analyzed in duplicate by ELISA.
  • CONCLUSIONS: Significant correlations were found between serum levels of TGF-alpha and IL-6, circadian patterns in wrist activity and serum cortisol and tumor-related symptoms in patients with metastatic colorectal cancer.
  • These data support the hypothesis that some cancer patient's symptoms of fatigue, poor QOL, and treatment outcome are related to tumor or host generated cytokines and could reflect cytokine effects on the circadian timing system.
  • This interplay between cytokine signaling pathways, the hypothalamic-pituitary-adrenal axis, the autonomic nervous system, and efferent pathways of the suprachiasmatic nucleus that control circadian physiology, opens the way to new rational interventions for symptom management in cancer patients.
  • [MeSH-major] Circadian Rhythm. Colorectal Neoplasms / immunology. Colorectal Neoplasms / psychology. Interleukin-6 / blood. Neoplasm Metastasis. Transforming Growth Factor alpha / blood. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 15755997.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR 00847
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-6; 0 / Transforming Growth Factor alpha; 0 / Tumor Necrosis Factor-alpha; WI4X0X7BPJ / Hydrocortisone
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31. Oh SJ, Hong YK, Song EK: Paroxysmal autonomic dysregulation with fever that was controlled by propranolol in a brain neoplasm patient. Korean J Intern Med; 2007 Mar;22(1):51-4
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  • [Title] Paroxysmal autonomic dysregulation with fever that was controlled by propranolol in a brain neoplasm patient.
  • Paroxysmal persistent hyperthermia after sudden mental change or neurologic deficit can develop via autonomic dysregulation without infection or any other causes of fever.
  • Paroxysmal hyperthermic autonomic dysregulation is a rare disease entity.
  • It manifests as a form of paroxysmal hypertension, fever, tachycardia, tachypnea, pupillary dilation, agitation and extensor posturing after traumatic brain injury, hydrocephalus, brain hemorrhage or brain neoplasm.
  • We recently experienced a case of paroxysmal hyperthermia following intracerebral hemorrhage along with brain neoplasm.
  • Propranolol is one of the most effective drugs for treating paroxysmal hyperthermia that is due to autonomic dysregulation.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Autonomic Nervous System Diseases / drug therapy. Brain Neoplasms / complications. Cerebral Hemorrhage / complications. Fever / drug therapy. Propranolol / therapeutic use

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  • (PMID = 17427648.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 9Y8NXQ24VQ / Propranolol
  • [Other-IDs] NLM/ PMC2687607
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32. Kaestner F, Mostert C, Behnken A, Boeckermann I, Ternes F, Diedrich M, Zavorotnyy M, Arolt V, Weckesser M, Rothermundt M: Therapeutic strategies for catatonia in paraneoplastic encephalitis. World J Biol Psychiatry; 2008;9(3):236-40
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  • This report is about a 40-year-old man suffering from fluctuating catatonia as main symptom of long-lasting paraneoplastic encephalitis caused by a testicular neoplasm.
  • With recurrence of a neoplasm initially diagnosed as seminoma after a 7-year symptom-free interval the patient suddenly developed various neurological and psychopathological symptoms including seizures, autonomic dysregulation, continuous anterograde short-term amnesia and predominantly a long-lasting complex catatonic syndrome with on-off phenomena.
  • Further neoplasm recurrences, however, reinforced catatonia until the tumour was successfully treated and the patient fully recovered.
  • [MeSH-major] Catatonia / complications. Catatonia / therapy. Electroconvulsive Therapy / methods. Paraneoplastic Syndromes, Nervous System / complications. Paraneoplastic Syndromes, Nervous System / pathology
  • [MeSH-minor] Adult. Electroencephalography. Humans. Magnetic Resonance Imaging. Male. Plasmapheresis. Testicular Neoplasms / pathology

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  • (PMID = 17853266.001).
  • [ISSN] 1562-2975
  • [Journal-full-title] The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • [ISO-abbreviation] World J. Biol. Psychiatry
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Scotland
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