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1. Elbayoumi TA, Torchilin VP: Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice. Int J Pharm; 2008 Jun 5;357(1-2):272-9
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  • [Title] Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice.
  • A mucocutaneous reaction in mice associated with Doxil treatment was identified as auricular erythema (AE).
  • Given that the immuno-targeting of Doxil to tumors was found to influence also its systemic biodistribution pattern, the attempt was made to exploit a specific targeting of Doxil to reduce the manifestation of this adverse reaction.
  • Tumor-bearing mice were used to study the biodistribution and skin-tissue accumulation effects of the tumor-targeted Doxil (the clinically used anti-cancer formulation) coupled with the anti-cancer monoclonal 2C5 antibody (mAb 2C5) as well as AE caused by Doxil application.
  • The modification of Doxil with mAb 2C5 resulted in a significant decrease in the normal skin accumulation of doxorubicin compared to original Doxil and substantially reduced AE.
  • Thus, targeting of Doxil with the anti-cancer mAb 2C5 not only can increase the tumor-specific accumulation of the drug, but also diminishes the cutaneous side effect of the original Doxil therapy.

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  • (PMID = 18329201.001).
  • [ISSN] 0378-5173
  • [Journal-full-title] International journal of pharmaceutics
  • [ISO-abbreviation] Int J Pharm
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL055519-12; United States / NHLBI NIH HHS / HL / R01 HL055519; United States / NHLBI NIH HHS / HL / R01 HL055519-12; United States / NHLBI NIH HHS / HL / R01 HL55519
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antibodies, Monoclonal; 0 / Indium Radioisotopes; 0 / Liposomes; 0 / Pharmaceutical Vehicles; 30IQX730WE / Polyethylene Glycols; 80168379AG / Doxorubicin
  • [Other-IDs] NLM/ NIHMS51910; NLM/ PMC2680692
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2. Lee MW, Nam SY, Choi HJ, Choi JH, Moon KC, Koh JK: Myoepithelioma of parotid gland presenting as infra-auricular subcutaneous mass. J Cutan Pathol; 2005 Mar;32(3):240-4
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  • [Title] Myoepithelioma of parotid gland presenting as infra-auricular subcutaneous mass.
  • Myoepithelioma is a rare but well-characterized group of tumours, among which myoepithelioma of the salivary glands is the best known.
  • We report two patients with myoepithelioma of parotid gland presenting as infra-auricular subcutaneous mass.
  • The lesions were clinically suspected to be epidermal cyst.
  • The biopsies revealed that most of the tumour cells showed epithelioid features with oval or spindle eosinophilic cytoplasm.
  • The tumour cells showed cytoplasmic immunoexpressions of vimentin, cytokeratin (AE1/AE3), S-100 protein and smooth muscle actin (SMA).
  • Myoepithelioma of parotid gland can be presented as a slowly growing tumour of pre- or infra-auricular area.
  • In dermatologic department, it can be misdiagnosed as various dermal or subcutaneous tumours.
  • [MeSH-major] Myoepithelioma / pathology. Parotid Neoplasms / pathology. Soft Tissue Neoplasms / diagnosis. Subcutaneous Tissue / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Keratins / metabolism. Male. Middle Aged. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 15701087.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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3. Liu L, Yang S, Han D, Huang D, Yang W: Primary tumours of the facial nerve: diagnostic and surgical treatment experience in Chinese PLA General Hospital. Acta Otolaryngol; 2007 Sep;127(9):993-9
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  • [Title] Primary tumours of the facial nerve: diagnostic and surgical treatment experience in Chinese PLA General Hospital.
  • CONCLUSIONS: The commonest manifestation of facial nerve tumours was facial paralysis, followed by hearing loss.
  • During tumour resection facial nerve continuity should be maintained and reconstructed in one stage wherever possible.
  • OBJECTIVE: To summarize the clinical characteristics of tumours of the facial nerve and discuss their diagnosis and treatment.
  • PATIENTS AND METHODS: Twenty-two cases of primary facial nerve tumours were reviewed.
  • RESULTS: Among the 22 cases, 14 were facial neurilemmomas, 6 were facial neurofibromas and 2 were facial nerve haemangiomas.
  • Facial paralysis was also the commonest sign of a facial nerve tumour (18/22), followed by a swollen mass in the tympanic cavity (8/22) and a swollen mass in the external auditory canal (5/22).
  • The 22 tumours were totally resected surgically.
  • The facial nerve was reconstructed in one stage when the tumours were resected, with facial-great auricular-facial nerve cable grafting (10 cases) and facial-lateral femoral cutaneous-facial nerve cable grafting (1 case).
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / surgery. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / surgery

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  • (PMID = 17712681.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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4. Perrot X, Fischer C: [Functional assessment of cochlear nerve and hearing]. Neurochirurgie; 2009 Apr;55(2):142-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Exploration fonctionnelle du nerf cochléaire et de l'audition.
  • RESULTS/DATA SYNTHESIS: Preoperative audiological evaluation makes it possible to assess pathology consequences on hearing.
  • Depending on auditory status, conservative surgery, including intraoperative auditory monitoring, can be planned.
  • Postoperative audiological evaluation provides the opportunity for monitoring: in the short term, to detect complications early, through BAEPs recorded in the nonoperated ear; in the long term, to detect recurrence of the pathology.
  • CONCLUSION: Auditory functional assessment is essential for optimal care of tumor or functional pathologies involving the cochlear nerve and/or the cerebellopontine angle.

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  • (PMID = 19298983.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Meta-Analysis; Review
  • [Publication-country] France
  • [Number-of-references] 61
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5. Seidler AM, Bramlette TB, Washington CV, Szeto H, Chen SC: Mohs versus traditional surgical excision for facial and auricular nonmelanoma skin cancer: an analysis of cost-effectiveness. Dermatol Surg; 2009 Nov;35(11):1776-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs versus traditional surgical excision for facial and auricular nonmelanoma skin cancer: an analysis of cost-effectiveness.
  • PARTICIPANTS: Input data were derived from results of a consecutive sample of 98 patients with nonmelanoma skin cancer on the face and ears, estimates in the literature on 5-year recurrence rates, and a query of healthy focus-group participants.
  • RESULTS: The Mohs strategy was $292 less expensive than the traditional surgical strategy and was more effective by an incremental quality-adjusted life year of 0.056 (translating to approximately 3 weeks of optimal quality of life).
  • Results were robust to subgroup and sensitivity analyses.
  • [MeSH-major] Ear Neoplasms / economics. Ear Neoplasms / surgery. Facial Neoplasms / economics. Facial Neoplasms / surgery. Mohs Surgery / economics. Skin Neoplasms / economics. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Cost-Benefit Analysis. Female. Humans. Male. Monte Carlo Method. Neoplasm Recurrence, Local. Quality-Adjusted Life Years


6. Ransom ER, Judy KD, Bigelow DC: Concurrent Cochlear Implantation with Resection of Skull Base Hemangiopericytoma following Sudden Deafness in an Only Hearing Ear. Skull Base; 2010 Jul;20(4):279-84
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  • [Title] Concurrent Cochlear Implantation with Resection of Skull Base Hemangiopericytoma following Sudden Deafness in an Only Hearing Ear.
  • A 72-year-old man with a known left acoustic neuroma, left-sided deafness, and a recently diagnosed right infratemporal fossa (ITF) hemangiopericytoma, presented with sudden deafness in his right ear.
  • Imaging revealed right-sided skull base extension and a large intracranial tumor component.
  • Complete tumor resection was possible, though invasion of the otic capsule was present.
  • Postoperative imaging confirmed complete tumor resection (Simpson grade I) and adequate CI placement.
  • Follow-up magnetic resonance imaging was performed at 6 and 12 months, and no tumor recurrence was seen.
  • Following adjuvant radiation, our patient remains disease free at 18 months.

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  • (PMID = 21311622.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3023313
  • [Keywords] NOTNLM ; Hemangiopericytoma / cochlear implant / infratemporal fossa / skull base tumor / sudden hearing loss
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7. Federspil PA: Auricular prostheses. Adv Otorhinolaryngol; 2010;68:65-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auricular prostheses.
  • An auricular prosthesis is an artificial substitute for the auricle; the term epithesis is used synonymously.
  • Advantages of implant-retained auricular prostheses include: optimal camouflage, predictable cosmetic results, fast rehabilitation, no donor site morbidity and early detection of tumor recurrence.
  • [MeSH-major] Ear Auricle. Prostheses and Implants

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20442562.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Silicon Compounds
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8. Roh JL: Resection of cervical vagal schwannoma via a post-auricular approach. Acta Otolaryngol; 2006 Mar;126(3):318-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection of cervical vagal schwannoma via a post-auricular approach.
  • However, because the conventional cervical approach leaves an incision scar in a visible area, other approaches need to be developed for young women who want the postoperative scar to be invisible.
  • A 28-year-old female underwent complete resection of a 4x4 cm tumor in her right upper neck via a post-auricular approach using an inverted V-shaped incision along the post-auricular sulcus and hairline.
  • The tumor was a schwannoma originating from the right cervical vagus nerve.
  • A cervical vagal schwannoma can be successfully removed by making an incision in a potentially invisible area.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neck / surgery. Neurilemmoma / surgery. Neurosurgical Procedures / methods. Vagus Nerve Diseases / surgery

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  • (PMID = 16618662.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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9. Xia Y, Xu S, Liu X, Chen AC: Photodynamic therapy as consolidation treatment for primary cutaneous adenoid cystic carcinoma: a case report. Photomed Laser Surg; 2010 Oct;28(5):707-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: A 53-year-old female patient presented with a lesion at the pre-auricular area.
  • After the final PDT treatment, the control pathological biopsy at the same location demonstrated no tumor cell in the specimen.
  • RESULTS: The 40-month follow-up diagnosis showed no evidence of recurrence or metastasis observed on the treated area.
  • CONCLUSION: ALA-PDT was a safe and effective therapy for obtaining good cosmetic results and reducing recurrence in this case report.
  • [MeSH-major] Aminolevulinic Acid / administration & dosage. Carcinoma, Adenoid Cystic / therapy. Facial Neoplasms / therapy. Photochemotherapy / methods. Skin Neoplasms / therapy. Surgical Procedures, Operative / methods
  • [MeSH-minor] Administration, Topical. Biopsy, Needle. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Photosensitizing Agents / administration & dosage. Treatment Outcome

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  • (PMID = 20929386.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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10. Wormser U, Brodsky B, Proscura E, Foley JF, Jones T, Nyska A: Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine. Arch Toxicol; 2005 Nov;79(11):660-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine.
  • Evaluation of mouse ear 3 h after SM exposure revealed acute inflammatory-cell aggregates in the vascular beds accompanied by strongly TNF-alpha-positive neutrophils.
  • In ear skin topically treated with iodine, however, no inflammatory cells were observed 3 h after SM exposure; 8 h postexposure, blood vessels contained very few TNF-alpha-positive inflammatory cells.
  • Iodine also scavenged hydroxyl radicals generated by glucose oxidase in a concentration-dependent manner.
  • The involvement of TNF-alpha in SM-induced skin toxicity was confirmed by reduction of 49 and 30% in ear edema following administration of 1 and 2 mug anti-TNF-alpha antibodies, respectively.
  • These findings were corroborated by quantitative analysis of the histological findings showing 46% reduction in acute inflammation and no signs of subacute inflammation in the treated group, in contrast to the control group treated with SM only.
  • The combination of iodine and antiTNF-alpha antibodies might constitute a new approach for treatment of SM-exposed individuals.
  • [MeSH-major] Anti-Inflammatory Agents / pharmacology. Iodine / pharmacology. Mustard Gas / toxicity. Tumor Necrosis Factor-alpha / immunology
  • [MeSH-minor] Administration, Topical. Animals. Antibodies / immunology. Antibodies / pharmacology. Dermatitis, Contact. Dermis / drug effects. Dermis / immunology. Dermis / pathology. Ear. Edema / chemically induced. Epidermis / drug effects. Epidermis / immunology. Epidermis / pathology. Hydroxyl Radical / metabolism. Male. Mice. Mice, Inbred ICR. Necrosis. Neutrophils / drug effects. Neutrophils / immunology. Respiratory Burst / drug effects

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  • (PMID = 16001271.001).
  • [ISSN] 0340-5761
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies; 0 / Tumor Necrosis Factor-alpha; 3352-57-6 / Hydroxyl Radical; 9679TC07X4 / Iodine; T8KEC9FH9P / Mustard Gas
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11. Leonetti JP, Anderson DE, Marzo SJ, Origitano TC, Vandevender D, Quinonez R: Facial paralysis associated with glomus jugulare tumors. Otol Neurotol; 2007 Jan;28(1):104-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial paralysis associated with glomus jugulare tumors.
  • OBJECTIVE: To review the intraoperative findings and facial nerve management in nine patients who presented with facial paralysis associated with glomus jugulare tumors.
  • PATIENTS: All patients who presented with facial paralysis and a glomus jugulare tumor who underwent surgical resection of their tumors at our institution.
  • INTERVENTION: A postauricular infratemporal fossa approach for tumor removal and greater auricular interposition neural repair.
  • MAIN OUTCOME MEASURE: Intraoperative facial nerve findings and long-term facial recovery.
  • RESULTS: One hundred two patients underwent a postauricular infratemporal approach for resection of glomus jugulare tumor from July 1988 through July 2005.
  • The medial surface of the vertical segment was invaded by tumor in all nine cases.
  • [MeSH-major] Facial Paralysis / etiology. Glomus Jugulare Tumor / complications
  • [MeSH-minor] Adult. Embolization, Therapeutic / methods. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Vascular Surgical Procedures / methods

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  • (PMID = 17195751.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Greve J, Bas M, Schipper J, Hoffmann TK: [Primary cutane manifestation of a precursor-B-lymphoblastic lymphoma in the external ear]. Laryngorhinootologie; 2008 Oct;87(10):728-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary cutane manifestation of a precursor-B-lymphoblastic lymphoma in the external ear].
  • [Transliterated title] Primäre kutane Manifestation eines Vorläufer-B-lymphoblastischen Lymphoms im Bereich des äusseren Ohres.
  • A Non-Hodgkin Lymphoma (NHL) represents nearly three percent of all malignant tumors.
  • We report on an extranodal B-cell-lymphoma of the ear in a young woman.
  • This infection led to the development of a massive ear tumor.
  • In spite of the considerable extent of the lymphoma there was no systemic manifestation and a total remission was induced by chemotherapy before adjuvant radiation.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear, External. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18633860.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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13. Huang Q, Wu H, Wang ZY, Yang J, Chen L, Jia H: [Diagnosis and treatment of chordoma in the jugular foramen area:three cases report]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;43(8):577-81
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  • For repairing facial nerve defect, great auricular nerve was used in 1 case and facial-hypoglossal anastomosis was used in another 2 cases.
  • RESULTS: The tumor were totally removed in all 3 cases.
  • CONCLUSIONS: Although chordoma originating from the jugular foramen area were extremely rare, it was possible to make early diagnosis through finding clinical feature and imaging methods.
  • Generally, the different surgical approaches were used according to the size and position of the tumor.
  • The classic infratemporal fossa approach for tumor removal and facial nerve reconstruction should be considered in the patients with chordoma around jugular foramen.
  • [MeSH-major] Chordoma / diagnosis. Chordoma / surgery. Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / surgery

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  • (PMID = 18959260.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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14. Bahadir O, Livaoglu M, Ural A: Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy. Indian J Plast Surg; 2008 Jul;41(2):201-5
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  • [Title] Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy.
  • Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor.
  • Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor.
  • Grafting material for the facial reconstruction was harvested from the great auricular nerve.
  • The proximal main trunk and each distal branch of the facial nerve were coapted with the greater auricular nerve.
  • Thus, the great auricular nerve is appropriate grafting material for coaptation of each distal branch of the facial nerve.

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  • [Cites] Am J Rhinol. 1999 Jul-Aug;13(4):311-4 [10485019.001]
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  • (PMID = 19753265.001).
  • [ISSN] 0970-0358
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2740500
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / facial nerve reconstruction / parotid gland / radiotherapy
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15. Leibovitch I, Huilgol SC, Richards S, Paver R, Selva D: The Australian Mohs database: short-term recipient-site complications in full-thickness skin grafts. Dermatol Surg; 2006 Nov;32(11):1364-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The objective was to evaluate the complications with FTSG in patients treated with MMS for cutaneous tumors.
  • RESULTS: The study group included 2,673 patients (50.2% men) with a mean age of 64+/-14 years.
  • Most tumors were basal call carcinoma (90.9%) and were located on the nose (63.8%), periocular area (14.8%), or auricular area (8.1%).
  • [MeSH-major] Skin Neoplasms / epidemiology. Skin Neoplasms / surgery. Skin Transplantation / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Australia / epidemiology. Carcinoma, Basal Cell / epidemiology. Carcinoma, Basal Cell / etiology. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Databases, Factual. Ear, External. Female. Forehead. Graft Survival. Humans. Male. Middle Aged. Mohs Surgery / statistics & numerical data. Nose. Postoperative Complications. Prospective Studies. Treatment Outcome

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  • (PMID = 17083589.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Rinaldo A, Devaney KO, Ferlito A: Merkel cell carcinoma of the auricle. Acta Otolaryngol; 2005 Feb;125(2):125-9
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  • Merkel cell carcinoma (MCC) is an uncommon cutaneous neoplasm which arises in adults with a peak incidence in the sixth and seventh decades.
  • Among head and neck primary sites, auricular MCC has proven to be rare and only 20 cases have been reported in the literature.
  • Auricular MCC follows the same aggressive course as has been documented for MCC arising elsewhere: the tumor has a propensity for recurring locally and metastasizing to regional lymph nodes and distant sites.
  • Location of MCC in the auricular regions does not appear to confer any survival advantage compared with MCC arising elsewhere.
  • What role regional node dissection, radiation therapy and chemotherapy may play in the standard treatment of auricular MCC remains to be clearly established.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Ear, External. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / radiotherapy. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged

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  • (PMID = 15880940.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 34
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17. Flores LP: Surgical results of the Hypoglossal-Facial nerve Jump Graft technique. Acta Neurochir (Wien); 2007 Dec;149(12):1205-10; discussion 1210
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  • [Title] Surgical results of the Hypoglossal-Facial nerve Jump Graft technique.
  • This paper aims to present the results of the Hypoglossal-Facial nerve Jump Graft technique in relation to facial musculature reanimation capability and hemitongue function preservation.
  • The surgical approach was characterised by the interposition of a short graft sutured to the distal stump of the transected facial nerve and sutured end-to-side to the hypoglossi, with cutting of only a third of the diameter of the latter.
  • FINDINGS: The facial nerve injuries were secondary to temporal bone trauma in five cases and to cerebellopontine angle tumour surgery in three.
  • Grafts were harvested from the greater auricular nerve in six patients and from the sural nerve in two.
  • The results of facial reanimation demonstrated facial symmetry and improvement in the facial tone in all cases, and classified as House-Brackmann grade IV in three (37.5%) and grade III in five (62.5%) patients.
  • CONCLUSIONS: The modification of the conventional technique of Hypoglossal-Facial nerve anastomosis by means of sectioning one third of the hypoglossal nerve area does not lead to dysfunction of this nerve and the surgical results in terms of facial reanimation are satisfactory.

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  • (PMID = 17978883.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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18. Sargent SJ, Frank LA, Buchanan BR, Donnell RL, Morandi F: Otoscopic, cytological, and microbiological examination of the equine external ear canal. Vet Dermatol; 2006 Jun;17(3):175-81
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  • [Title] Otoscopic, cytological, and microbiological examination of the equine external ear canal.
  • Otoscopic examination and cytology of the equine ear would be beneficial in diseases such as head trauma, headshaking, otitis externa secondary to otitis media, vestibular disease, aural neoplasia and aural pruritus secondary to parasites.
  • In practice, otic examinations of horses are rarely done due to the perceived difficulty in visualizing the equine external ear canal and tympanic membrane, as well as the need for chemical restraint.
  • In this study, the proximal external ear canal was examined in live horses using a handheld otoscope and in cadaver heads using video otoscopy.
  • Visualization of the proximal ear canal of the sedated horse could be done with a handheld otoscope, but more sedation or general anaesthesia and a video otoscope would be required to adequately visualize the tympanic membrane in the live horse.
  • The proximal ear canals of 18 horses were examined cytologically and cultured aerobically.
  • Ten of the 21 ears had mixed growth with low numbers of organisms (Corynebacterium sp. being most common).
  • Two of the 21 ears had heavy growth of a single organism (Corynebacterium sp. and Staphylococcus intermedius, respectively).
  • Equine cadaver heads were examined in cross-section by computed tomography (CT) imaging and histopathology in order to further understand the anatomy of the equine external ear canal.
  • Equine practitioners should be aware that otic examination is possible and may provide important diagnostic information.
  • [MeSH-major] Ear Canal. Horse Diseases / diagnosis. Otoscopy / veterinary
  • [MeSH-minor] Animals. Cadaver. Corynebacterium / growth & development. Corynebacterium / isolation & purification. Diagnosis, Differential. Female. Horses. Male. Staphylococcus / growth & development. Staphylococcus / isolation & purification. Tomography, X-Ray Computed / veterinary

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  • (PMID = 16674732.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. Yoon T, Benito-Ruiz J, García-Díez E, Serra-Renom JM: Our algorithm for nasal reconstruction. J Plast Reconstr Aesthet Surg; 2006;59(3):239-47
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  • Nasal tissue defects can be caused by tumor removal, trauma or by any other insult to the nasal pyramid, like cocaine abuse, developing an irreversible sequela.
  • In our department, 35 patients were operated on between 2000 and 2002: three bilobed flaps, five nasolabial flaps, two V-Y advancement flaps from the sidewall, three dorsonasal flaps modified by Ohsumi, 19 paramedian forehead flaps, three cheek advancement flaps, three costocondral grafts, two full-thickness skin grafts and two auricular helix free flaps for alar reconstruction.

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  • (PMID = 16673535.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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20. Charpiot A, Chambres O, Herve JF, Million P, Riedinger AM, Hemar P: [Osteointegrated cranio-facial implants: 49 patients report]. Rev Laryngol Otol Rhinol (Bord); 2006;127(4):217-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Implants ostéointégrés cranio-faciaux. A propos de 49 patients.
  • OBJECTIVES: To analyze the results obtained in the total implanted population in Strasbourg, in order to assess the reliability of this technique over the long-term, especially in children and in irradiated patients.
  • METHODS: This is a retrospective study including all the cases of cranio-facial epitheses implanted in the department of Otorhinolaryngology, head and neck surgery at the University Hospital of Strasbourg since 1992, date of the first epithesis implantation.
  • The results (rate of osseo-integration, cutaneous complications, degree of satisfaction) are presented according to the site of implantation and the antecedent of irradiation.
  • The results obtained in children (16 years of age and less) are specified.
  • RESULTS: The study involved 50 patients (including 11 children), that is 51 epitheses, auricular, orbito-palpebral or naso-maxillary.
  • 142 implants were fixed, including 49 in irradiated patients.
  • It is particularly interesting in oncology, as it allows easy clinical monitoring of the operation site.

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  • (PMID = 17315785.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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21. Lu L, Ding Y, Lin Y, Xu Z, Li Z, Qu J, He Y, Dai Y, Chen Y, Qiu J: [Greater auricular nerve graft for repair of facial nerve defects]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Apr;24(7):293-6
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  • [Title] [Greater auricular nerve graft for repair of facial nerve defects].
  • OBJECTIVE: To retrospectively analysis the clinical data of facial nerve defects repair with greater auricular nerve graft.
  • In 3 patients of facial nerve tumors, the tumors involved multiple nerve segments, and histologic results were all schwannomas, preoperatively, 1 case had Grade III function, 2 cases had Grade V function.
  • In 2 patients of iatrogenic trauma of the facial nerve, the primary disease was chronic otitis media with cholesteatoma, the lesions were localized at the mastoid segment and the second genu respectively.
  • In addition to 3 cases lost to follow-up, the remaining patients, 4 recovered to a Grade III, 3 to a Grade VI, 2 to a Grade V and 2 remained at Grade VI.
  • Facial nerve reconstruction by means of greater auricular nerve grafting was a practical and effective method, the best postoperative recovery of facial nerve function was Grade III.
  • [MeSH-minor] Adult. Ear / innervation. Female. Humans. Male. Mastoid / surgery. Middle Aged. Nerve Regeneration. Retrospective Studies. Temporal Bone / injuries. Temporal Bone / surgery. Young Adult

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  • (PMID = 20545110.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. Huang X, Zheng Y, Liu X, Sun W, Zeng L, Cai X, Liu W, Xu Y, Zhang Z, Huang H: A comparison between endoscope-assisted partial parotidectomy and conventional partial parotidectomy. Otolaryngol Head Neck Surg; 2009 Jan;140(1):70-5
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  • RESULTS: The endoscopic surgery lasted for 108.61 +/- 11.86 minutes and the bleeding volume was significantly lower than in the conventional group.
  • All 18 patients were satisfied with their cosmetic results; 14 patients (65%) were satisfied with the great auricular nerve preservation; only one patient had temporary facial paresis and salivary fistula.
  • There was no tumor recurrence in both groups during the follow-up after 26 to 40 months) the endoscope-assisted parotidectomy group (median 30 months, range 26-40 months) and conventional group (median 32 months, range 26-40 months).
  • [MeSH-minor] Adult. Blood Loss, Surgical. Feasibility Studies. Female. Humans. Male. Parotid Neoplasms / surgery. Patient Satisfaction. Time Factors. Ultrasonic Therapy

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  • (PMID = 19130965.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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23. Lin WN, Huang HC, Wu CC, Liao CT, Chen IH, Kan CJ, Huang SF: Analysis of acinic cell carcinoma of the parotid gland - 15 years experience. Acta Otolaryngol; 2010 Dec;130(12):1406-10
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  • Surgery alone would be sufficient in early-stage tumor.
  • Postoperative adjuvant treatment in advanced-stage patients or those with positive resection margins usually gives satisfactory control of the disease.
  • OBJECTIVES: AciCC is a rare tumor in parotid gland malignancy.
  • RESULTS: Thirteen male and 12 female patients ranged in age from 16 to 84 years (mean 37.5 years) at the time of diagnosis.
  • Most patients (92%) presented with symptoms of infra-auricular mass.
  • The tumor stage distributions of the patients were 24%, 44%, 28%, and 4% for stages I, II, III, and IV, respectively.
  • The 10-year disease-free and overall actuarial survivals were both 84% in a mean follow-up of 75.8 months.
  • [MeSH-major] Carcinoma, Acinar Cell / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease-Free Survival. Dose Fractionation. Female. Follow-Up Studies. Humans. Lymphatic Irradiation. Male. Middle Aged. Neoplasm Staging. Parotid Gland / pathology. Parotid Gland / surgery. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Young Adult

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  • (PMID = 20809887.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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24. Hashim II, Motoyama K, Abd-Elgawad AE, El-Shabouri MH, Borg TM, Arima H: Potential use of iontophoresis for transdermal delivery of NF-kappaB decoy oligonucleotides. Int J Pharm; 2010 Jun 30;393(1-2):127-34
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  • In mouse model of skin inflammation, iontophoretic delivery of NF-kappaB decoy ODN significantly reduced the increase in ear thickness caused by phorbol ester as well as the protein and mRNA expression levels of tumor necrosis factor-alpha (TNF-alpha) in the mice ears.
  • These results suggest that iontophoresis is a useful and promising enhancement technique for transdermal delivery of NF-kappaB decoy ODN.
  • [MeSH-major] Dermatitis / therapy. Genetic Therapy / methods. Iontophoresis. NF-kappa B / genetics. Oligonucleotides / administration & dosage. Skin / metabolism
  • [MeSH-minor] Administration, Cutaneous. Animals. Diffusion Chambers, Culture. Disease Models, Animal. Female. Male. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Permeability. RNA, Messenger / metabolism. Tetradecanoylphorbol Acetate. Time Factors. Tumor Necrosis Factor-alpha / metabolism

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  • Hazardous Substances Data Bank. 12-O-TETRADECANOYLPHORBOL-13-ACETATE .
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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20417264.001).
  • [ISSN] 1873-3476
  • [Journal-full-title] International journal of pharmaceutics
  • [ISO-abbreviation] Int J Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / Oligonucleotides; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; NI40JAQ945 / Tetradecanoylphorbol Acetate
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25. Cribier B, Scrivener Y, Peltre B: Neural hyperplasia in chondrodermatitis nodularis chronica helicis. J Am Acad Dermatol; 2006 Nov;55(5):844-8
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  • As controls, we investigated 25 tumors of the ear with the same methods.
  • RESULTS: Large nerves (>0.1 mm in diameter) were seen in 8 of 37 cases; these were close to the cartilage or at the upper part of the ulceration.
  • Nerve hyperplasia was not observed in tumors of the ear, even in ulcerated cases.
  • LIMITATIONS: Hypothesis based on morphologic observations.
  • This finding may explain the induction of pain by light pressure, whereas ulcerated auricular malignant tumors are generally painless.
  • [MeSH-major] Cartilage Diseases / pathology. Dermatitis / pathology. Ear Cartilage / innervation. Ear Diseases / pathology. Ear, External / innervation. Nerve Tissue / pathology

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  • (PMID = 17052491.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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26. Dib LL, de Oliveira JA, Neves RI, Sandoval RL, Nannmark U: Auricular rehabilitation by means of bone grafting from the iliac crest in combination with porous extraoral implants: a case report. Clin Implant Dent Relat Res; 2007 Dec;9(4):228-32
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  • [Title] Auricular rehabilitation by means of bone grafting from the iliac crest in combination with porous extraoral implants: a case report.
  • The use of extraoral fixtures as bone anchorage was introduced many years ago and since then many patients were rehabilitated with better results.
  • MATERIALS AND METHODS: A new porous surfaced Brazilian extraoral implant (MasterExtra, Conexão, Sistema de Próteses, São Paulo, Brazil) was used.
  • RESULTS: Eight months after grafting, four fixtures were inserted.
  • Three fixtures were used for connection of an auricular epithesis.
  • [MeSH-major] Carcinoma, Basal Cell / rehabilitation. Ear, External / surgery. Head and Neck Neoplasms / rehabilitation. Prostheses and Implants. Prosthesis Implantation
  • [MeSH-minor] Adult. Bone Transplantation. Female. Humans. Neoplasm Recurrence, Local. Porosity. Skin Transplantation. Vibration

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  • (PMID = 18031445.001).
  • [ISSN] 1523-0899
  • [Journal-full-title] Clinical implant dentistry and related research
  • [ISO-abbreviation] Clin Implant Dent Relat Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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27. Wang RC, Barber AE, Ditmyer M, Vantine P: Distal facial nerve exposure: a key to partial parotidectomy. Otolaryngol Head Neck Surg; 2009 Jun;140(6):875-9
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  • 2) Be able to incorporate other modifications of parotidectomy including preservation of the great auricular nerve, superficial musculo-aponeurotic system (SMAS), and parotid duct.
  • STUDY DESIGN: Case series with chart review of partial parotidectomy for benign neoplasms and intraparotid lymph nodes, using antegrade (Group 1) or distal (Group 2) facial nerve exposure, and those conserving the great auricular nerve, SMAS, and parotid duct (Group 3).
  • The great auricular nerve, parotid duct, and SMAS were preserved when possible.
  • RESULTS: No difference in facial nerve function was found between the groups.
  • Group 3 had better ear lobule cutaneous sensation.
  • CONCLUSIONS: Partial parotidectomy utilizing distal facial nerve exposure can reduce the extent of surgical dissection, facilitate preservation of the parotid duct and great auricular nerve, and allow greater flexibility in the choice of skin and SMAS incisions.
  • [MeSH-major] Facial Nerve / anatomy & histology. Facial Nerve / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19467407.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Gierek T, Majzel K, Zbrowska-Bielska D, Gołab L, Jezierska M: [Treatment results in external and middle ear malignant neoplasms of patients treated at the Laryngology Department of Medical University of Silesia between 1991-2001]. Otolaryngol Pol; 2005;59(2):183-7
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  • [Title] [Treatment results in external and middle ear malignant neoplasms of patients treated at the Laryngology Department of Medical University of Silesia between 1991-2001].
  • The authors present 18 patients with malignant neoplasms of the ear and temporal bone who were treated in the Clinic of Laryngology Medical University of Silesia in Katowice in the years 1991-2001.
  • The neoplasm was located on the auricle in 7 patients (39%), in the external auditory canal in 4 (22%) patients, in the middle ear in 5 patients (28%) and in 2 cases (11%) it was difficult to establish primary site.
  • The best outcomes were in auricular neoplasms.
  • The treatment results were much worse in neoplasms of the external auditory canal and the middle ear.
  • Over 3 year follow-up in 10 patients (55%) with ear and temporal bone neoplasms shows no recurrence.
  • [MeSH-major] Ear Neoplasms / therapy. Ear, External. Ear, Middle. Skull Neoplasms / therapy. Temporal Bone
  • [MeSH-minor] Adult. Aged. Carcinoma, Squamous Cell / therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16095085.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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29. Trojanowska A, Trojanowski P, Olszanski W, Klatka J, Drop A: How to reliably evaluate middle ear diseases? Comparison of different methods of post-processing based on multislice computed tomography examination. Acta Otolaryngol; 2007 Mar;127(3):258-64
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  • [Title] How to reliably evaluate middle ear diseases? Comparison of different methods of post-processing based on multislice computed tomography examination.
  • OBJECTIVES: Evaluation of cross-sectional images, multiplanar 2-D reformations, 3-D reconstructions and virtual endoscopy (VE) in assessment of the middle ear in inflammatory diseases, trauma, otosclerosis and tumours.
  • Comparison of each method and correlation with surgical findings.
  • MATERIALS AND METHODS: Investigations were carried out in 80 patients with middle ear pathology.
  • The value of native scans information, 2-D, 3-D reconstructions and VE of the tympanic cavity structures was assessed in comparison to intraoperative findings.
  • RESULTS: MPR reconstructions were most useful in the assessment of skull base trauma, skull base tumours and in cases of chronic middle ear inflammation.
  • Highly vascularized tumours, disruption of ossicular chain and stapes prosthesis were best evaluated on 3-D reconstructions.
  • [MeSH-major] Ear Diseases / radiography. Ear, Middle / radiography. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Otoscopy. Tomography, Spiral Computed. User-Computer Interface
  • [MeSH-minor] Adult. Aged. Ear Neoplasms / radiography. Female. Humans. Male. Middle Aged. Otitis Media / radiography. Otosclerosis / radiography. Petrous Bone / radiography. Sensitivity and Specificity. Skull Base / injuries. Skull Base / radiography. Skull Base Neoplasms / radiography. Skull Fractures / radiography

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  • (PMID = 17364362.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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30. Zhi KQ, Deng PF, Ren WH, Zhang L, Li XQ, Wen YM: [A clinical retrospective study on modified parotidectomy in benign tumors of parotid gland]. Shanghai Kou Qiang Yi Xue; 2008 Jun;17(3):229-32
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  • [Title] [A clinical retrospective study on modified parotidectomy in benign tumors of parotid gland].
  • Group 2(55 cases) was treated with preserving the fascia parotideomasseterica and great auricular nerve and partial parotidectomy.
  • Tumor size, blood loss, operating time, temporary facial paralysis, tumour recurrence were compared between the two groups.
  • The incidence of Frey's syndrome was clinically evaluated by Minor test (starch-iodine test).
  • The feeling of the region around the auricular lobule was also evaluated.
  • RESULTS: There was no significant difference between the two groups in tumor size, temporary facial paralysis and tumor recurrence.
  • The incidence rate of Frey's syndrome in Group 1 was significantly lower than that in Group 2 by objective observation and Minor test.
  • There was significant difference between the feeling of pro- operation and pre-operation in the auricular lobule.
  • CONCLUSIONS: The modified parotidectomy is a function-preserving surgery for benign parotid tumours, which improves the cosmetics, the feeling around ear, reduces the duration of surgery, and the incidence rate of Frey's syndrome.
  • [MeSH-minor] Ear Auricle. Face. Facial Paralysis. Humans. Postoperative Complications. Retrospective Studies. Sweating, Gustatory

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  • (PMID = 18661059.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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31. Yu LM, Yang SM, Han DY, Huang DL, Yang WY: [Management of operative complications in acoustic neuroma surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jan;41(1):26-30
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  • RESULTS: Of 110 cases, the most frequent complication was hearing disability which occurred in 95 cases (95/110, 86.4%).
  • Ten cases with CSF subcutaneous retro-auricular had been successfully controlled by conservative treatment.
  • CONCLUSIONS: The key factors to avoid the complications include mastering the anatomy of different surgical approach, how much of the tumor size, surgical experience and preoperative evaluation of patients' imaging information and other clinical data.

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  • (PMID = 16646239.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Halin C, Tobler NE, Vigl B, Brown LF, Detmar M: VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood; 2007 Nov 1;110(9):3158-67
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  • Lymphangiogenesis is involved in tumor cell metastasis and plays a major role in chronic inflammatory disorders.
  • To investigate the role of lymphangiogenesis in inflammation, we induced and maintained delayed-type hypersensitivity (DTH) reactions in the ears of mice and then analyzed the resulting lymphangiogenesis in the inflamed tissue and draining lymph nodes (LNs) by quantitative fluorescence-activated cell sorting (FACS) and by immunofluorescence.
  • Long-lasting inflammation induced a significant increase in the number of lymphatic endothelial cells, not only in the inflamed ears but also in the ear-draining auricular LNs.
  • Inflammation-induced lymphangiogenesis was potently blocked by systemic administration of a vascular endothelial growth factor (VEGF)-A neutralizing antibody.
  • These findings were explained by analysis of both VEGF-A protein and mRNA levels, which revealed that VEGF-A was expressed at high mRNA and protein levels in inflamed ears but that expression was increased only at the protein level in activated LNs.
  • Inflammation-induced lymphangiogenesis in LNs was independent of the presence of nodal B lymphocytes, as shown in B cell-deficient mice.

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  • (PMID = 17625067.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA092644; United States / NCI NIH HHS / CA / R01 CA069184; United States / NCI NIH HHS / CA / CA 69184; United States / NCI NIH HHS / CA / CA 92644
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 0 / vascular endothelial growth factor A, mouse
  • [Other-IDs] NLM/ PMC2200913
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33. Chadha A, Grob M, Soldin M: Use of the earlobe in auricular reconstruction post tumour extirpation. J Plast Reconstr Aesthet Surg; 2009 Apr;62(4):539-41
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  • [Title] Use of the earlobe in auricular reconstruction post tumour extirpation.
  • Flap vascularity is satisfactory and although the overall size of the ear is reduced, this is accepted for a rejuvenated shape and minimal morbidity.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Ear Auricle / surgery. Ear Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery

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  • (PMID = 18061546.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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34. Naumann IC, Miyamoto RT: Large asymptomatic pneumocephalus developing years after middle cranial fossa surgery--a case report. Auris Nasus Larynx; 2009 Aug;36(4):470-3
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  • We describe a patient with a supra-auricular soft-tissue swelling as the only presenting symptom of a large chronic epidural pneumocele with extension into the extracranial subcutaneous tissues.
  • It presented several years after surgical resection of a meningioma that involved the temporal bone.
  • [MeSH-major] Cranial Fossa, Middle / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Pneumocephalus / etiology. Postoperative Complications

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  • (PMID = 19097717.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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35. Zhang DK, Guo ZM, Zhang Q, Zeng ZY, Chen FJ, Chen WK, Li H, Wang SL: [Application of helix water jet to parotid surgery]. Ai Zheng; 2008 Jan;27(1):105-8
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  • METHODS: Clinical data of 43 patients with parotid tumors, who received operation with helix water jet from Feb.
  • RESULTS: The postoperative drainage volume was significantly lower in water jet group than in control group [(9.89+/-3.74) mL vs. (12.15+/-2.11) mL, P<0.05].
  • Nine patients who retained nervus auricularis magnus suffered from slight numbness symptom of auricular lobule.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Dissection / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 18184476.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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36. Lee DK, Kim JH, Cho YS, Chung WH, Hong SH: Salivary gland choristoma of the middle ear in an infant: a case report. Int J Pediatr Otorhinolaryngol; 2006 Jan;70(1):167-70
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  • [Title] Salivary gland choristoma of the middle ear in an infant: a case report.
  • Salivary gland choristoma of the middle ear cavity is an extremely rare entity.
  • We report another case of salivary choristoma of the middle ear in an 11-month-old girl.
  • We performed a reconstruction surgery of the hearing mechanism, as well as tumor removal, and achieved satisfactory hearing results.
  • If no remarkable facial nerve anomaly is detected in the preoperative evaluation, the reconstruction of the hearing mechanism with complete tumor removal might be considered.
  • [MeSH-major] Choristoma / diagnosis. Choristoma / surgery. Ear Diseases / diagnosis. Ear Diseases / surgery. Ear, Middle. Salivary Glands

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  • (PMID = 16076497.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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37. Güerrissi JO: Total forehead flap: hemicraniofacial giant congenital melanocytic nevus. J Craniofac Surg; 2009 Mar;20(2):522-4
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  • Being non-hair-bearing and relatively thin and having similar color and texture of the skin of the forehead provide an excellent characteristic not only for nasal reconstruction but also in other facial areas.
  • Tumor resection and reconstructive aspect were planned in 3 stages. (1) Excision of the tumor located in the cheek, nose, and both upper and lower left lids.
  • The nose was resurfaced by means of a total skin graft. (2) resection of the temporoparietal nevus. (3) Treatment of the tumor involving the ocular structures.
  • Total forehead flap was outlined, permitting carryout of skin of the total forehead area, and the blood supply was originated from the frontal and parietal branches of the temporal superficial artery and secondarily by anastomosis with the branches arising from both homolateral auricular and occipital vessels.
  • [MeSH-major] Facial Neoplasms / congenital. Nevus, Pigmented / congenital. Reconstructive Surgical Procedures / methods. Skin Neoplasms / congenital. Skin Transplantation / methods. Surgical Flaps
  • [MeSH-minor] Adult. Cheek / surgery. Conjunctival Neoplasms / congenital. Conjunctival Neoplasms / surgery. Eyelid Neoplasms / congenital. Eyelid Neoplasms / surgery. Follow-Up Studies. Forehead. Head and Neck Neoplasms / congenital. Head and Neck Neoplasms / surgery. Humans. Male. Nose Neoplasms / congenital. Nose Neoplasms / surgery. Scalp / pathology. Temporal Arteries / pathology. Tissue and Organ Harvesting

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  • (PMID = 19326491.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Wang LL, Gao QH, Zheng GJ, Wang XY, Zhou L, Wang CM, Wen YM: [Embolization and degradation of arteries in vivo by pingyangmycin albumin microspheres]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2009 Mar;40(2):279-83
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  • PYM hydrochloride + 0.9% NaCl, PYM + soybean oil, and PYM-AMS + soybean oil were injected into the central auricular arteries of the rabbits in the three experimental groups, respectively, for about 30 seconds (0.26 mL/per ear, which contained PYM 5 mg/mL).
  • RESULTS: The PYM + 0.9% NaCl group had no significant vessel changes.
  • At the 21st day, mild proliferation of endothelial cells and walls of central auricular arteries were observed, especially on the intima.
  • In the PYM-AMS group, the central auricular arteries were narrowed at the 7th day after injection.
  • At the 14th day, significant proliferation of endothelial cells and walls of central auricular arteries were observed.
  • At the 21st day, the walls of central auricular arteries and some small veins proliferated obviously, and the arteries were sclerostenosed.
  • CONCLUSION: PYM-AMS may become an option for the treatment of large venous or arteriovenous malformations and for the local chemotherapy of malignant tumors.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Bleomycin / analogs & derivatives. Chemoembolization, Therapeutic / methods. Endothelial Cells / drug effects. Serum Albumin, Bovine

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  • (PMID = 19462907.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Serum Albumin, Bovine; 11056-06-7 / Bleomycin; 11116-32-8 / bleomycetin
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39. Leonetti JP, Anderson DE, Marzo SJ, Origitano TC, Petruzzelli GJ: Intratemporal Grafting of the Facial Nerve following Lateral Skull Base Tumor Resection. Skull Base; 2007 May;17(3):181-6
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  • [Title] Intratemporal Grafting of the Facial Nerve following Lateral Skull Base Tumor Resection.
  • Intratemporal skull base tumors may invade the facial nerve in the horizontal (tympanic) or descending (vertical) segments, while parotid malignancies typically infiltrate the facial nerve at the stylomastoid foramen.
  • This article will describe our results following intratemporal facial nerve grafting in 44 patients.
  • METHODS: This was a retrospective analysis of 44 patients requiring intratemporal facial nerve repair following lateral skull base tumor resection at our tertiary care, academic medical center.
  • RESULTS: Tumor histology included 17 parotid cancers, 13 temporal bone malignancies, 9 glomus tumors, 3 facial neuromas, and 2 endolymphatic sac tumors.
  • The greater auricular nerve was used in 25 patients and the sural nerve was used in 19 cases.

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  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
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40. Sehgal R, Karcavich R, Carlson S, Belecky-Adams TL: Ectopic Pax2 expression in chick ventral optic cup phenocopies loss of Pax2 expression. Dev Biol; 2008 Jul 1;319(1):23-33
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  • Pax2 is essential for the development of the urogenital system, neural tube, otic vesicle, optic cup and optic tract [Dressler, G.R., Deutsch, U., et al., 1990.
  • PAX2, a new murine paired-box-containing gene and its expression in the developing excretory system.
  • Development 109 (4), 787-795; Nornes, H.O., Dressler, G.R., et al., 1990.
  • Development 109 (4), 797-809; Eccles, M.R., Wallis, L.J., et al., 1992.
  • Expression of the PAX2 gene in human fetal kidney and Wilms' tumor.
  • Cell Growth Differ 3 (5), 279-289].
  • Within the visual system, a loss-of-function leads to lack of choroid fissure closure (known as a coloboma), a loss of optic nerve astrocytes, and anomalous axonal pathfinding at the optic chiasm [Favor, J., Sandulache, R., et al., 1996.
  • The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Proc. Natl. Acad. Sci. U. S. A. 93 (24), 13870-13875; Torres, M., Gomez-Pardo, E., et al., 1996.
  • Pax2 contributes to inner ear patterning and optic nerve trajectory.
  • In ovo electroporation of Pax2 into the chick ventral optic cup results in the formation of colobomas, a condition typically associated with a loss of Pax2 expression.
  • Further, ectopic expression of Pax2 in RPE appears to have non-cell autonomous effects on adjacent RPE, creating an ectopic neural retina in place of the RPE.

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  • (PMID = 18485342.001).
  • [ISSN] 1095-564X
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY019525-01; United States / NEI NIH HHS / EY / R01 EY019525-01
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PAX2 Transcription Factor; 147336-22-9 / Green Fluorescent Proteins; 148997-75-5 / Fibroblast Growth Factor 8
  • [Other-IDs] NLM/ NIHMS222527; NLM/ PMC2917900
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41. Lee A, Clarke L, Bance M: Vestibular schwannoma: how much residual hearing is useful? J Otolaryngol Head Neck Surg; 2008 Jun;37(3):399-410
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  • OBJECTIVE: The objective of this study was to determine the usefulness of residual hearing in the tumour ear in vestibular schwannoma patients.
  • METHODS: Thirty-three vestibular schwannoma patients and 13 controls underwent QuickSIN (Etymotic Research Inc, Elk Grove, IL) speech-in-noise testing with the tumour and good ears open and occluded.
  • Nine testing conditions used three speakers with speech signal from the tumour side, the front, and the good ear side, with noise in other speakers.
  • MAIN OUTCOME MEASURES: Tumour ear contribution (TEC) was calculated by the decrease in score with the index ear occluded.
  • RESULTS: The strongest correlation was between the pure-tone average (PTA) and the TEC with signal from the tumour side.
  • Multiple regression analysis with TEC and sound from the tumour ear as the dependent variable showed that the SDS and PTA of the tumour ear are significant independent predictors (p = .049 and .037, respectively).
  • CONCLUSION: The main contribution of residual hearing is in signals from the tumour side.

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  • (PMID = 19128646.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
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42. Ramina R, Maniglia JJ, Fernandes YB, Paschoal JR, Pfeilsticker LN, Coelho Neto M: Tumors of the jugular foramen: diagnosis and management. Neurosurgery; 2005 Jul;57(1 Suppl):59-68; discussion 59-68
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  • [Title] Tumors of the jugular foramen: diagnosis and management.
  • OBJECTIVE: Jugular foramen tumors are rare cranial base lesions that present diagnostic and management difficulties.
  • With the availability of new diagnostic procedures these tumors have been more precisely studied and questions of whether, when, and how these lesions should be treated often arise.
  • METHODS: The tumors were approached by a multidisciplinary team composed of neurosurgeons, ear, nose, and throat surgeons, and neuroradiologists.
  • The same surgical technique was used to resect all tumors.
  • The internal carotid artery was infiltrated in two patients, and a saphenous graft bypass was carried out before removal of the lesions.
  • The facial nerve was reconstructed with nerve grafts (great auricular nerve) or XII/VII anastomosis in five cases.
  • Postoperative radiotherapy was carried out for malignant and invasive tumors.
  • RESULTS: Paragangliomas were the most frequent lesions, followed by schwannomas and meningiomas.
  • Complete excision was possible in 89% of benign tumors and 80% of paragangliomas.
  • CONCLUSION: Radical removal of benign jugular foramen tumors is the treatment of choice and may be curative.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / surgery. Embolization, Therapeutic / methods. Glomus Jugulare Tumor / diagnosis. Glomus Jugulare Tumor / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Female. Glomus Jugulare / pathology. Glomus Jugulare / surgery. Humans. Male. Middle Aged. Retrospective Studies. Skull Base Neoplasms. Treatment Outcome

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  • (PMID = 15987570.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Patrizi A, Tabanelli M, Filippi G, Gurioli C, Nozza P, Savoia F, Dalmonte P, Misciali C: An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. Dermatol Online J; 2010;16(5):4
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  • [Title] An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy.
  • A 13-year-old boy presented to us for the evaluation of a slowly growing mass over the left preauricular region.
  • The findings of magnetic resonance imaging (MRI) and vascular MRI led us to suspect a vascular growth.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of the soft tissue with fibrohistiocytic and vascular differentiation that shows an intermediate malignancy grade, mainly occurs in patients younger than 20 years of age, and is usually localized on the extremities.
  • Angiomatoid fibrous histiocytoma is considered to be a tumor of intermediate malignancy because of its less aggressive course in contrast to conventional malignant fibrous histiocytoma (MFH).
  • Our case of AFH is peculiar because of its localization in the pre auricular region and because it appeared in a young patient.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Ear, External. Humans. Male

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  • (PMID = 20492821.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Korotkikh NG, Ol'shanskiĭ MS, Shcherbinin AS, Stepanov IV, Alekseeva TV, Ovsiannikov IuM: [Endovascular microembolization of the posterior auricular artery in comprehensive surgical management of capillary angioma of the floor of the auricle]. Angiol Sosud Khir; 2007;13(4):74-6
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  • [Title] [Endovascular microembolization of the posterior auricular artery in comprehensive surgical management of capillary angioma of the floor of the auricle].
  • The article deals with the description of a rare clinical case wherein a 44-year-old female patient presenting with bleeding capillary angioma of the left auricle obstructing the auditory passage was fist subjected to endovascular microembolization of the posterior auricular artery by means of polyvinyl alcohol (PVA-500), followed by a second stage of virtually bloodlessly surgical removal of the tumour carried out five days thereafter.
  • Preoperative microembolization of a bleeding haemangioma arrests haemorrhage from the tumour, resulting in the decreased size thereof, as well as leading to circumscribing the tumour from healthy tissue.
  • Attention is paid to the fact that embolization of the auricular artery should be performed only after a thorough angiographic evaluation of the pattern of the blood flow in the tumour and adjacent vessels by means of the technique of selective catheterization and using only the officinal emboli.
  • [MeSH-major] Ear Neoplasms / therapy. Ear, External / blood supply. Embolization, Therapeutic / methods. Hemangioma, Capillary / therapy

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  • (PMID = 18385652.001).
  • [ISSN] 1027-6661
  • [Journal-full-title] Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery
  • [ISO-abbreviation] Angiol Sosud Khir
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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45. Schmid DW, Di Summa PG, Wettstein R, Erba P, Wassim R, Kalbermatten DF: Posterior auricular perichondrial cutaneous graft combined with cartilage strip in nostril reconstruction. Eplasty; 2008;8:e42
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  • [Title] Posterior auricular perichondrial cutaneous graft combined with cartilage strip in nostril reconstruction.
  • METHOD: A perichondrial cutaneous graft (PCCG), a graft consisting of a perichondral layer, fatty tissue, and skin that is harvested retroauriculary, is combined with an attached cartilage strip.
  • CONCLUSION: First, a strip of cartilage had been included in a PCCG where tumor resection required sacrifice of more than 50% of the alar rim.

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  • (PMID = 18806870.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2519965
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46. Karsidag S, Ozcan A, Ozkaya O, Ugurlu K, Bas L: Use of wide bipedicled pericranial flap in anterior scalp reconstruction. J Craniofac Surg; 2009 Nov;20(6):2248-51
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  • The multiple blood supply of the pericranial tissue enables this versatility, with a rich, anastomosing arterial supply from the supraorbital, supratrochlear, superficial temporal, posterior auricular, and occipital vessels.
  • After tumor excision was completed, a pericranial flap was planned on the caudal side of the defect.
  • A bipedicle-based pericranial flap was outlined with the use of a sharp dissection; this flap was elevated in a submusculoaponeurotic plane.
  • The bipedicled pericranial flap, whose arterial supply was from the superficial and posterior auricular arteries, was transposed to the frontal defect.We preferred a bipedicled flap, whose arterial supply is from the superficial temporal and posterior auricular arteries to augment vascular supply.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Scalp / surgery. Skin Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Ear, External / blood supply. Fascia / transplantation. Humans. Male. Middle Aged. Periosteum / transplantation. Skin Transplantation


47. Sun W, Xu YD, Zheng YQ, Liu X, Zeng L, Liu W, Huang X: Endoscope-assisted partial-superficial parotidectomy through two small skin incisions. Acta Otolaryngol; 2009 Dec;129(12):1493-7
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  • CONCLUSION: Endoscope-assisted partial-superficial parotidectomy is a feasible method for treatment of benign parotid superficial lobe tumors located at the anterior or the inferior of the auricular lobule.
  • The main advantage of this procedure is that the small operative scar resulted in improved cosmetic results.
  • PATIENTS AND METHODS: Thirty cases with benign parotid superficial lobe tumors with a diameter < 30 mm located at the anterior or the inferior of the auricular lobule underwent endoscope-assisted partial-superficial parotidectomy via retrograde approach through two small skin incisions.
  • RESULTS: All 30 operations were successfully performed endoscopically.
  • All the patients were satisfied with the cosmetic results.
  • There was no tumor recurrence during the follow-up after 26-50 months.
  • [MeSH-major] Endoscopy. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19922103.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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48. Kitagaki M, Hirota M: Auricular chondritis caused by metal ear tagging in C57BL/6 mice. Vet Pathol; 2007 Jul;44(4):458-66
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  • [Title] Auricular chondritis caused by metal ear tagging in C57BL/6 mice.
  • Although it has been shown that auricular chondritis in rats is caused by the use of metal identification ear tags, the pathogenesis remains unclear.
  • Based on the hypothesis that the auricular chondritis is caused by metal ions released from metal identification ear tags, we investigated the pathogenesis in male C57BL/6 mice tagged with metal identification ear tags.
  • Twenty-six weeks after the attachment of the ear tags, visible increases in the thickness of the auricle were observed, and the concentrations of copper and iron in the tagged ears were significantly increased (P < .05) in the tagged ears compared with the untagged ears.
  • Histopathologically, there were observed severe chondritis with extensive granulomatous inflammation, newly formed cartilage nodules, and osseous metaplasia accompanied by cellular infiltrates, such as CD4 T lymphocyte, macrophages, neutrophils, and mast cells, and expression of Th1 cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2 in the tagged ear.
  • Based on these results, we concluded that the release of copper and iron ions from the metal ear tags played a major role in the onset of auricular chondritis.
  • Subsequent cellular interactions, such as CD4 T cells, macrophages, fibroblasts, and mast cells, mediated by cytokines, such as tumor necrosis factor-alpha and interferon-gamma, caused an autoimmune response that may have led to the progression of auricular chondritis as an autoimmune disease.
  • [MeSH-major] Animal Identification Systems. Cartilage Diseases / veterinary. Ear Diseases / veterinary. Metals / adverse effects

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  • (PMID = 17606507.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Metals; 9038-94-2 / Metallothionein
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49. Chu SM, Young YH: Ipsilateral and contralateral vestibular schwannomas in unilateral long-term deaf ears. Eur Arch Otorhinolaryngol; 2007 Jun;264(6):693-6
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  • In the past decade, we have encountered two patients with unilateral long-term deaf ear having vestibular schwannoma.
  • One was on the deaf ear in a 53 years' woman and the other was on the contralateral hearing ear in a 62 years' woman.
  • These two patients had total deafness on the right ear since childhood, associated with absent auditory brainstem response (ABR) and caloric responses, whereas normal ABR and caloric responses were shown on the left ear.
  • Although similar physiological findings were disclosed on the deaf ears, MRI scan demonstrated vestibular schwannoma on the different side, that is, one in deaf ear and the other in hearing ear.
  • For the former, absent ABR and caloric results indicate that the tumor originates from the superior vestibular nerve.
  • In contrast with the latter, normal ABR and caloric responses, but absent vestibular-evoked myogenic potentials on the hearing ear imply that the tumor originates from the inferior vestibular nerve.
  • The ipsilateral tumor on the deaf ear underwent intracranial surgical excision, followed by radiosurgery due to tumor recurrence 10 years later, while the contralateral one on the only hearing ear received radiosurgery only.
  • [MeSH-minor] Audiometry, Pure-Tone. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Radiosurgery / methods. Stereotaxic Techniques

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  • (PMID = 17476518.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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50. Madsen AR, Gundgaard MG, Hoff CM, Maare C, Holmboe P, Knap M, Thomsen LL, Buchwald C, Hansen HS, Bretlau P, Grau C: Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001. Head Neck; 2008 Oct;30(10):1332-8
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  • [Title] Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001.
  • BACKGROUND: In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival.
  • Surgery was limited to tumor excision and mastoidectomy and in 1 case temporal bone excision.
  • RESULTS: Twenty-seven of 28 recurrences involved primary site.
  • Kaplan-Meier analysis showed 5-year locoregional control of 48%, disease-specific survival 57%, and overall survival 44%.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / therapy. Ear Canal. Ear Neoplasms / pathology. Ear Neoplasms / therapy. Ear, Middle
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Denmark. Female. Humans. Kaplan-Meier Estimate. Male. Medical Records. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Prognosis. Retrospective Studies. Temporal Bone / pathology. Temporal Bone / surgery. Treatment Outcome. Young Adult

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc. Head Neck 2008.
  • (PMID = 18704969.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Tokuriki A, Iyoda T, Inaba K, Ikuta K, Fujimoto S, Kumakiri M, Yokota Y: Dual role for Id2 in chemical carcinogen-induced skin tumorigenesis. Carcinogenesis; 2009 Sep;30(9):1645-50
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  • By using a two-step chemical carcinogenesis protocol, we evaluated the role of Id2 in skin tumor formation in mice.
  • Twenty weeks after the initiation, the number of tumors formed in the Id2(-/-) mice was 3.5-fold higher than that in their wild-type littermates, whereas the diameter of tumors in the Id2(-/-) mice was about half of that of the tumors in the wild-type mice.
  • In the Id2(-/-) mice, epidermal gammadelta T cells, which play a key role in immunosurveillance against skin tumor development, were barely detectable.
  • Although histological analyses demonstrated no apparent difference in tumor cell type, tumor vessel formation or apoptosis, the proportion of proliferating cells was reduced in the tumors in the Id2(-/-) mice compared with those in the wild-type mice.
  • In the wild-type mice, the expression of Id2 was enhanced in skin tumors compared with that in ear epidermal cells.
  • Biochemical analysis demonstrated that cyclin D1 was reduced at the protein level in the tumors in the Id2(-/-) mice, whereas other factors such as cyclin E and p27 were not altered significantly.
  • Our results reveal that Id2 plays a dual role in skin tumorigenesis by suppressing tumor development through the establishment of epidermal gammadelta T cell-mediated skin immunosurveillance and by promoting tumor cell proliferation via the control of the cyclin D1 protein level.
  • [MeSH-major] Inhibitor of Differentiation Protein 2 / physiology. Skin Neoplasms / chemically induced


52. Pajor A, Stańczyk R, Durko T: [Malignant neoplasms of external and middle ear]. Otolaryngol Pol; 2005;59(2):251-6
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  • [Title] [Malignant neoplasms of external and middle ear].
  • [Transliterated title] Nowotwory złośliwe ucha zewnetrznego i środkowego.
  • INTRODUCTION: Neoplasms of external and middle ear are rare, which cause several problems in diagnosis and therapy.
  • The purpose of the study was to analyze retrospectively patients with malignant neoplasms of the ear.
  • METHODOLOGY: The study was carried out on 53 patients treated for malignant ear neoplasms in single institution during 25 years (1978-2002).
  • RESULTS: The most frequent neoplasm was squamous cell carcinoma--36 cases (67.9%), then basal cell carcinoma--9 cases (16.9%).
  • Neoplasm primarily involved auricle in 26 patients (49.1%), external auditory canal in 15 patients (28.3%) and middle ear in 12 patients (22.6%).
  • They were classified according to Stell and McCormick (1985) as follows: stage I--29 tumours (54.7%), stage T2--15 tumours (28.3%), stage T3--9 tumours (17%).
  • The characteristics of neoplasms related to the site of location were described.
  • The difficulties in precise histopathologic diagnosis and extent of disease were pointed out.
  • RESULTS: Neoplasms of external and middle ear constitute a group of various histopathological and clinical tumours, which differ in diagnostic difficulties, treatment and prognosis.
  • A diagnosis was often made in advanced stages of neoplasms, especially for middle ear tumours, that diminished a possibility of effective treatment.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Ear, Middle
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Ossicular Prosthesis. Retrospective Studies

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  • (PMID = 16095097.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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53. Zarrin-Khameh N, Spoden JE, Tran RM: Angiolymphoid hyperplasia with eosinophilia associated with pregnancy: a case report and review of the literature. Arch Pathol Lab Med; 2005 Sep;129(9):1168-71
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  • A case of angiolymphoid hyperplasia with eosinophilia (ALH) is reported in a 33-year-old woman who developed an auricular nodule during the second trimester of her pregnancy.
  • The auricular tumor was completely excised.
  • Thirteen months after excision, the patient remains tumor free.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Ear Neoplasms / pathology. Eosinophils / pathology. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / metabolism. Arteriovenous Malformations / diagnosis. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Keratosis / diagnosis. Neurilemmoma / diagnosis. Pregnancy

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  • (PMID = 16119993.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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54. Green AC, Kimlin M, Siskind V, Whiteman DC: Hypothesis: hair cover can protect against invasive melanoma on the head and neck (Australia). Cancer Causes Control; 2006 Dec;17(10):1263-6
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  • Men of the same age showed no corresponding changes in ear melanoma.
  • However incidence rates of ear melanoma in general were fourfold higher in males than females in Australia.
  • Further, using data from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program, rates of invasive melanoma on the ear were found to be sevenfold higher in males than females in the US population in the same period.
  • We therefore speculated that the isolated rises of ear melanoma in younger women in Australia, and the higher overall rates of ear, scalp and neck melanoma in men compared with women, reflect differences in hair coverage.
  • We tested the specific hypothesis that hair cover reduces sun exposure of the ears using experimental manikins and found that hair cover of the ear reduced solar ultraviolet-B exposure by 81% [SE +/-8] compared with uncovered ears.
  • We conclude that hair cover can protect against invasive melanoma on the ear and may similarly protect on the scalp and neck.
  • [MeSH-major] Hair / physiology. Head / pathology. Head and Neck Neoplasms / prevention & control. Melanoma / pathology. Melanoma / prevention & control. Models, Biological
  • [MeSH-minor] Adult. Australia. Ear / radiation effects. Female. Humans. Incidence. Male. Middle Aged. Neck / pathology. Neoplasm Invasiveness. Ultraviolet Rays

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  • [Cites] J Pharm Sci. 2004 Jul;93(7):1780-95 [15176066.001]
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  • (PMID = 17111257.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC1705485
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55. Steiner MA, Khan M, May BB, Schlakman B, Vijayakumar V: Giant recurrent glomus jugulotympanicum with intracranial, extracranial, and nasophayngeal extension: The imaging role in clinical management. Radiol Case Rep; 2009;4(4):314
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  • We present a 50-year-old male with a massive glomus jugulotympanicum that demonstrated extracranial extension breaking through the skin in the posterior auricular region, intracranial extension into the middle cranial fossa, and nasopharyngeal extension involving the entire length of the eustachian tube.
  • Characteristic CT, MR, angiographic, and pathologic findings are demonstrated in this case.
  • The difficult decision regarding treatment options must be made with careful consideration of the associated morbidities of slow tumor growth and recurrence with conservative management versus the surgical morbidities of aggressive surgical resection.
  • Imaging is arguably the most important component of this decision-making process, with the radiologist contributing significantly to multiple aspects of the management of glomus tumors.

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  • (PMID = 27307834.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4898170
  • [Keywords] NOTNLM ; CT, computed tomography / EAC, external auditory canal / IAC, internal auditory canal / MRI, magnetic resonance imaging
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56. Bień S, Kamiński B, Kopczyński J, Sygut J: [The synchroneous tumors of different histopathology in the parotid salivary gland]. Otolaryngol Pol; 2006;60(5):703-8
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  • [Title] [The synchroneous tumors of different histopathology in the parotid salivary gland].
  • Ipsilateral salivary gland tumors of different histological types are very rare.
  • 2005), in 6 (3.06%) cases synchronous tumors of different type has been found in pathologic specimens.
  • In 5 cases pleomorphic adenoma was one of synchronous tumor--in 2 cases with adenocarcinoma and in single cases with salivary duct carcinoma, adenolymphoma, and myoepithelioma.
  • In one case, the adenolymphoma was synchronous with carcinoma planoepitheliale metastaticum from the primary in the skin post auricular area (late metastasis).
  • Following the review of literature concerning the problem, two concepts has been critically discussed--the real synchronous occurrence of two different tumors, and transformation of benign tumor of salivary neoplasm to its malignant form.
  • [MeSH-major] Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Adult. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 17263242.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 24
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57. Cordova A, Pirrello R, D'Arpa S, Moschella F: Superior pedicle retroauricular island flap for ear and temporal region reconstruction: anatomic investigation and 52 cases series. Ann Plast Surg; 2008 Jun;60(6):652-7
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  • [Title] Superior pedicle retroauricular island flap for ear and temporal region reconstruction: anatomic investigation and 52 cases series.
  • BACKGROUND: On the basis of a previously published anatomic study on the superior auricular artery (SAA) and on a series of 52 consecutive cases, the authors propose a new superior pedicle retroauricular island flap (SP-RIF) for defects of the upper half of the ear and for temporal region or superficial helical defects.
  • METHODS: Twenty five auricular regions were dissected after colored latex injection in the carotid artery of 13 fresh cadavers to investigate the SAA.
  • A SP-RIF was used in 52 consecutive cases after tumor excision.
  • In 51 cases, the defect involved the upper half of the ear.
  • RESULTS: The SAA originates either from the superficial temporal artery (44%) or from its parietal branch (56%).
  • Esthetic results of the reconstruction were excellent.
  • CONCLUSIONS: The SP-RIF can be considered as a first choice option to repair nonmarginal losses of substance of the upper half of the ear.
  • [MeSH-major] Ear, External / surgery. Face / anatomy & histology. Face / surgery. Reconstructive Surgical Procedures / methods. Skin Transplantation / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cadaver. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Ear Neoplasms / surgery. Esthetics. Humans. Middle Aged

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  • (PMID = 18520202.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Wirth GA, Sundine MJ, Kong AP, Carpenter PM: Auricular angioleiomyoma: a case report and review of the literature. Ear Nose Throat J; 2007 May;86(5):281-3
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  • [Title] Auricular angioleiomyoma: a case report and review of the literature.
  • A 29-year-old woman presented with an unusual lesion on the right auricular antihelix.
  • The mass was resected, and a staged reconstruction was performed.
  • Most cases of angioleiomyoma involve the extremities; few have been described in the head and neck region, and very few of those have been reported on the ear.
  • Among those auricular angioleiomyomas that have been reported, most were distinctly painless.
  • We report a new, atypical case of this unusual tumor.
  • [MeSH-major] Angiomyoma / pathology. Ear Neoplasms / pathology. Ear, External / pathology

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  • (PMID = 17580807.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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59. Layadi F, Aniba K, Lmejjati M, Aït Elqadi A, Aït Benali S: [Giant osteoid osteoma of the posterior skull base. A case report and literature review]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):128-32
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  • [Transliterated title] Ostéome ostéoïde géant de l'étage postérieur de la base du crâne. A propos d'un cas et revue de la littérature.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones.
  • OBSERVATION: We report a rare case of a large osteoid osteoma of the petro-occipital area in a 26-year-old man.
  • He presented with clinical sign of raised intracranial pressure, cerebellar symptoms and large left retro-auricular swelling.
  • CONCLUSION: Although benign and rare, osteoid osteoma can present with neurological deficit due to mass effect and involvement of nervous structures especially in the posterior skull base.
  • [MeSH-major] Osteoma / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 16840973.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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60. Karosi T, Jókay I, Kónya J, Petkó M, Szabó LZ, Pytel J, Jóri J, Sziklai I: Activated osteoclasts with CD51/61 expression in otosclerosis. Laryngoscope; 2006 Aug;116(8):1478-84
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  • HYPOTHESIS: Stapes ankylosis is supposed to be a disease with variable histopathology caused by otosclerosis or pseudo-otosclerosis.
  • Persistent measles virus infection of the otic capsule could induce reactivation of quiescent embryonic osteoclasts in otosclerosis.
  • Amplification results were correlated to postoperative histologic and CD51/61 specific immunohistologic findings.
  • RESULTS: Among 261 stapes fixation cases, 175 otosclerotic stapes contained measles virus RNA.
  • CONCLUSION: The presence of CD51/61 positive osteoclasts in otosclerotic bone containing viral sequences provides the basis for an inflammatory bone remodeling disorder.
  • Otosclerosis is a disease caused by persistent measles virus infection and reactivation of resting embryonic osteoclasts in the otic capsule.
  • [MeSH-major] Antigens, CD / analysis. Antigens, Neoplasm / analysis. Glycoproteins / analysis. Integrin beta3 / analysis. Osteoclasts / physiology. Otosclerosis / pathology

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  • (PMID = 16885757.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Neoplasm; 0 / CD52 antigen; 0 / Glycoproteins; 0 / Integrin beta3; 0 / RNA, Viral
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61. Zehlicke T, Punke C, Haase K, Boltze C, Pau HW: [Myxoma of the middle ear-a rare cause of facial palsy]. HNO; 2008 Feb;56(2):165-8
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  • [Title] [Myxoma of the middle ear-a rare cause of facial palsy].
  • [Transliterated title] Das Myxom des Mittelohrs als mögliche Ursache einer temporären Fazialisparese.
  • In case of the co-occurrence of facial palsy and inflammation-like symptoms of the same ear, the differential diagnosis is focused on viral (herpes zoster) or bacterial diseases.
  • We report a patient for whom the surgical exploration of the middle ear revealed a benign tumor: a myxoma.
  • These neoplasias are rare tumors in the head and neck region.
  • The typical tumor site is the atrium of heart.
  • In the ear, the tumor grows slowly and remains asymptomatic unless it irritates structures such as the facial nerve or the vestibular organ.
  • Histologically, the tumor presents a "myxoid" matrix that is rich in acid mucopolysaccarides.
  • Using the case presented, we discuss the causality between the tumor and the facial palsy, although during the operation the bony canal of the nerve was found to be intact.
  • In any cases with clinically and radiologically unclear findings of the ear in connection with facial palsy, surgical exposure should be considered.
  • [MeSH-major] Ear Neoplasms / complications. Ear, Middle. Facial Paralysis / etiology. Myxoma / complications

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  • [Cites] HNO. 1969 Apr;17 (4):113-5 [5405595.001]
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  • (PMID = 17115088.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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62. Osborne RF, Shaw T, Zandifar H, Kraus D: Elective parotidectomy in the management of advanced auricular malignancies. Laryngoscope; 2008 Dec;118(12):2139-45
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  • [Title] Elective parotidectomy in the management of advanced auricular malignancies.
  • OBJECTIVE: The purpose of this study is to determine whether elective parotidectomy is necessary in patients with clinically and radiographically N0 parotid disease with isolated primary auricular nonmelanoma cutaneous malignancies.
  • Auricular malignancies are typically managed by wedge resection or wide local excision.
  • Although small lesions are easily managed by conservative excision, large bulky tumors, those with multifocal involvement, and recalcitrant lesions, often require more extensive resection including total auriculectomy, parotidectomy, and/or neck dissection.
  • Patients with a clinical history of advanced nonmelanoma auricular carcinoma undergoing elective parotidectomy and/or neck dissection with clinically and radiographically N0 nodal disease were evaluated for the presence of occult parotid metastasis.
  • All patients underwent parotidectomy in conjunction with a total auriculectomy for surgical extirpation of their primary auricular carcinoma.
  • Parotid specimens were evaluated for histopathologic evidence of metastatic neoplastic disease.
  • RESULTS: Pathological examination showed no histological evidence of occult parotid metastasis in all 19 patients who underwent elective parotidectomy in the presence of clinically and radiographically N0 nodal disease of the parotid or cervical regions.
  • CONCLUSIONS: Parotidectomy may not be necessary in the surgical management of advanced auricularcarcinoma in the absence of clinically positive parotid disease or external auditory canal involvement.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Ear Neoplasms / surgery. Ear, External. Elective Surgical Procedures. Parotid Gland / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Ear Canal / pathology. Female. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Parotid Neoplasms / pathology. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery. Retrospective Studies. Risk Factors

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  • (PMID = 19029866.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Nair SP, Moorthy KP, Suprakasan S, Jayapalan S, Mini G: Histoid leprosy - unusual presentation. Int J Dermatol; 2006 Apr;45(4):433-4
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  • The past medical and family history were non-contributory.
  • Pertinent findings included the aforementioned well-defined, asymmetric, shiny papules (Fig. 1).
  • There were multiple, discrete, erythematous, pedunculated, tumor-like masses of various sizes over the right thigh (Fig.
  • 2) and a well-defined 4 cm x 3 cm ulcer on the second toe of the left foot, the floor of which was covered by necrotic slough.
  • The greater auricular, ulnar, radial cutaneous and common peroneal nerves were thickened bilaterally, but non-tender.
  • The differential diagnosis for the tumor-like thigh masses included dermatofibroma, neurofibroma, and Kaposi's sarcoma.
  • The ear lobe smear (ELS) for acid-fast bacilli showed a bacterial index (BI) of 6+[> 1000 organisms/oil immersion field (oif)] and a morphological index (MI) of 50%.
  • Biopsy of the papules and pedunculated tumors showed a well-circumscribed area of the dermis packed with many acid-fast organisms and foamy macrophages, consistent with histoid leprosy (Fig. 3).

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  • (PMID = 16650172.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leprostatic Agents
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64. Lehnerdt G, Schmitz KJ, Dost P, Koch DA, Jahnke K: [Histological criteria and metastasis of squamous cell carcinoma of the pinna]. Laryngorhinootologie; 2005 Jul;84(7):482-6
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  • [Transliterated title] Histologische Kriterien und Metastasierungshäufigkeit von Plattenepithelkarzinomen der Ohrmuschel.
  • As soon as cartilage is infiltrated, irrespective of other criteria like tumour size, SCC of the thin skin of the pinna are classified as T4 category.
  • As therapy considerably depends on the TNM stage a review of the prognostic value of cartilage infiltration as well as other histological criteria seems to be justified.
  • RESULTS: In 36 cases a histological re-evaluation could be performed on the original tumour samples (34 male symbol : 2 female symbol; average age was 76 years, with an age interval of 54 - 99 years).
  • 36 % of SCC cases had infiltration of the auricular cartilage.
  • Statistical analysis did not show a statistical correlation of either cartilage infiltration, tumour size bigger than 2 cm or 1 cm, tumour grading and tumour depth with regard to lymph node metastases.
  • DISCUSSION: According to our results, cartilage infiltration as single criterion of inclusion into a T4 category should be analysed cautiously.
  • A survey of a bigger group of patients e. g. as a multicenter study would be desirable for such a rare malignancy.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Ear Neoplasms / pathology. Ear, External / pathology. Lymphatic Metastasis / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Practice Guidelines as Topic. Prognosis. Retrospective Studies. Skin / pathology. Statistics as Topic


65. Del Sordo R, Colella R, Leite S, Sidoni A: [Cutaneous angiomyolipoma: a case report and literature review]. Pathologica; 2005 Jun;97(3):137-40
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  • Herein we describe an adding case located on the ear in 58-year-old man reviewing the pertinent literature.
  • [MeSH-major] Angiomyolipoma / pathology. Ear Neoplasms / pathology. Ear, External / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Male. Middle Aged. Neoplasm Proteins / analysis

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  • (PMID = 16259281.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Number-of-references] 10
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66. Adriane K, Huang J, Ding G, Chen J, Liu Y: Self assembled magnetic PVP/PVA hydrogel microspheres; magnetic drug targeting of VX2 auricular tumours using pingyangmycin. J Drug Target; 2006 May;14(4):243-53
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  • [Title] Self assembled magnetic PVP/PVA hydrogel microspheres; magnetic drug targeting of VX2 auricular tumours using pingyangmycin.
  • With advances in material science, magnetic drug targeting has emerged as one of the viable ways of attaining this.
  • In this study, we used self assembled PVP/PVA magnetic hydrogel microspheres to deliver pingyangmycin (Bleomycin A5) to rabbit auricular VX2 tumours in the presence of a 0.5 T permanent magnet both during and 24 h after perfusion.
  • A total of 22 New Zealand white rabbits ranging from 13 to 16 weeks and weighing 2.5-3.0 kg (2.46 +/- 0.2) successfully implanted with tumours 200-300 mm2 in size were used.
  • However, when compared to the group with 1 mg pingyangmycin(BLM) in 50 mg of ferrofluid and 0.5 mg (BLM) in 50 mg ferrofluid both with a permanent magnet in place for 24 h, the statistically significant difference was in favor of combined treatment, i.e. ferrofluid carrying drug in presence of a permanent magnet (p = 0.01).
  • The microspheres in conjunction with the magnet did deliver pingyangmycin to the tumour and hence may be of use in future as far as magnetic drug targeting is concerned.
  • However, more studies are still required to establish biodistribution and biostability not to forget drug release of ferrofluid of different chemotherapeutic agents available.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bleomycin / analogs & derivatives. Drug Delivery Systems. Ear Neoplasms / drug therapy. Hydrogel / administration & dosage. Magnetics. Microspheres
  • [MeSH-minor] Animals. Drug Carriers. Polyvinyl Alcohol. Povidone. Rabbits

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  • (PMID = 16777683.001).
  • [ISSN] 1061-186X
  • [Journal-full-title] Journal of drug targeting
  • [ISO-abbreviation] J Drug Target
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Carriers; 11056-06-7 / Bleomycin; 11116-32-8 / bleomycetin; 25852-47-5 / Hydrogel; 9002-89-5 / Polyvinyl Alcohol; 9003-39-8 / Povidone
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67. Bernateck M, Becker M, Schwake C, Hoy L, Passie T, Parlesak A, Fischer MJ, Fink M, Karst M: Adjuvant auricular electroacupuncture and autogenic training in rheumatoid arthritis: a randomized controlled trial. Auricular acupuncture and autogenic training in rheumatoid arthritis. Forsch Komplementmed; 2008 Aug;15(4):187-93
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  • [Title] Adjuvant auricular electroacupuncture and autogenic training in rheumatoid arthritis: a randomized controlled trial. Auricular acupuncture and autogenic training in rheumatoid arthritis.
  • OBJECTIVE: The efficacy of auricular electroacupuncture (EA) was directly compared with autogenic training (AT).
  • Primary outcome measures were the mean weekly pain intensity and the disease activity score 28 (DAS 28); secondary outcome measures were the use of pain medication, the pain disability index (PDI), the clinical global impression (CGI) and pro-inflammatory cytokine levels, which were assessed during the study period and 3 months after the end of treatment.
  • RESULTS: At the end of the treatment and at 3-month follow-up a clinically meaningful and statistically significant improvement (p < 0.05) could be observed in all outcome parameters and both groups.
  • The erythrocyte sedimentation rate in the EA group was significantly reduced (p = 0.010), and the serum concentration of tumor necrosis factor-alpha was significantly increased compared to the AT group (p = 0.020).
  • The treatment effects of auricular EA were more pronounced.
  • [MeSH-major] Acupuncture, Ear / methods. Arthritis, Rheumatoid / therapy. Autogenic Training. Electroacupuncture / methods

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  • [Copyright] Copyright (c) 2008 S. Karger AG, Basel.
  • [CommentIn] Forsch Komplementmed. 2008 Oct;15(5):286; author reply 286 [19009726.001]
  • (PMID = 18787327.001).
  • [ISSN] 1661-4127
  • [Journal-full-title] Forschende Komplementärmedizin (2006)
  • [ISO-abbreviation] Forsch Komplementmed
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Switzerland
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68. Acartürk TO, Yiğenoğlu B, Pekedis O: Excision and "transcutaneous" lift in patients with neurofibromatosis of the fronto-temporo-orbital and auricular regions. J Craniofac Surg; 2009 May;20(3):771-4
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  • [Title] Excision and "transcutaneous" lift in patients with neurofibromatosis of the fronto-temporo-orbital and auricular regions.
  • Neurofibromatosis (NF) type 1 (von Recklinghausen disease) involves the face in up to 4% of the cases.
  • Patients present with varying degrees of disfigurement according to the extent and location of the tumor.
  • Many surgeons prefer multiple serial excisions, as it is almost impossible to remove the entire tumor without major extirpative surgery.
  • However, because the "debulkings" are usually not accompanied by durable lift procedures, the skin sags again because of the gravitational effect on the remaining tumor.
  • In a series of 7 patients with NF of the frontal, temporal, facial, and cervical areas and the auricle, a lift procedure was performed after functional debulking of the tumor.
  • The lift sutures, which passed transcutaneously, supported and fixed the predetermined areas on the skin or the ear cartilage to the periosteum of the calvarium.
  • After 1 year, because of the presence of disease, there was a slow relapse in the amount of sagging in the temporal and frontal areas, but not in the auricle.
  • In 3 patients, re-excision of the disease and repeat lift procedure using the same technique were performed after 1 year.
  • All were satisfied with the results and stated that the period without sagging lasted longer compared with their prior surgeries.
  • The patients with NF type 1 undergo many operations during their lifetime.
  • These procedures are not aimed to completely eliminate the disease, but rather to improve function and appearance.
  • When these debulking procedures are combined with durable lifting procedures, the results are longer lasting with improved quality of life.
  • [MeSH-major] Facial Neoplasms / surgery. Neurofibromatosis 1 / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Suture Techniques
  • [MeSH-minor] Adolescent. Adult. Ear, External / surgery. Esthetics. Feedback. Female. Follow-Up Studies. Forehead / surgery. Head and Neck Neoplasms / surgery. Humans. Male. Neoplasm Recurrence, Local / surgery. Orbit / surgery. Patient Care Planning. Patient Participation. Patient Satisfaction. Quality of Life. Reoperation. Retrospective Studies. Temporal Bone / surgery. Young Adult


69. Ben Slama L, Hasni W, Royer B: [Cat-scratch disease localisation in the parotid gland]. Rev Stomatol Chir Maxillofac; 2008 Jun;109(3):183-6
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  • [Title] [Cat-scratch disease localisation in the parotid gland].
  • [Transliterated title] Localisation parotidienne d'une maladie des griffes du chat.
  • INTRODUCTION: Cat scratch disease is an infection due to Bartonella henselae.
  • It is one of the principal causes of benign chronic adenopathy in children or young adults.
  • CASE REPORT: A 36-year-old woman presented with a left parotid pre-auricular swelling suggesting a pleiomorphic adenoma.
  • The history and complementary tests (ultra sonography, MRI, cytopuncture, B. henselae serology) led to a diagnosis of cat scratch disease.
  • DISCUSSION: The parotid localization of cat scratch disease is very rare.
  • When a patient presents with parotid swelling, the distinction between a tumor and lymph node is not easy.
  • [MeSH-major] Cat-Scratch Disease / diagnosis. Parotid Diseases / diagnosis
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Bartonella henselae / isolation & purification. Diagnosis, Differential. Doxycycline / therapeutic use. Female. Humans. Parotid Neoplasms / diagnosis

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  • (PMID = 18533210.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; N12000U13O / Doxycycline
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70. Fujiwara T, Maeda M, Kuwae K, Nakagawa T, Nakao K: Free-prefabricated auricular composite graft: a new method for reconstruction following extended hemilaryngectomy. Br J Plast Surg; 2005 Mar;58(2):153-7
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  • [Title] Free-prefabricated auricular composite graft: a new method for reconstruction following extended hemilaryngectomy.
  • A free-prefabricated auricular composite graft was applied in two patients who underwent extended hemilaryngectomy.
  • [MeSH-major] Artificial Organs. Ear, External / surgery. Laryngeal Neoplasms / surgery. Laryngectomy / methods. Neck Dissection / methods. Surgical Flaps. Thyroid Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Microsurgery / methods. Neoplasm Recurrence, Local / surgery

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  • (PMID = 15710107.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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71. Mailler-Savage EA, Neal KW Jr, Godsey T, Adams BB, Gloster HM Jr: Is levofloxacin necessary to prevent postoperative infections of auricular second-intention wounds? Dermatol Surg; 2008 Jan;34(1):26-30; discussion 30-1
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  • [Title] Is levofloxacin necessary to prevent postoperative infections of auricular second-intention wounds?
  • BACKGROUND: Surgeons may prescribe oral quinolones after auricular procedures to prevent postoperative infections, especially those caused by Pseudomonas aeruginosa.
  • OBJECTIVE: This study compares the efficacy of levofloxacin and local wound care to local wound care alone in preventing postoperative infection of auricular second-intention wounds.
  • MATERIALS AND METHODS: This study was a prospective, randomized trial of 84 consecutive patients (82 in the final analysis) who underwent Mohs micrographic surgery for an auricular neoplasm and had a wound left to heal by second intention.
  • RESULTS: Overall, 85.4% of patients had no complications.
  • CONCLUSION: Levofloxacin is not necessary to prevent postoperative infections of auricular second-intention wounds after Mohs surgery.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Ear Auricle / surgery. Levofloxacin. Mohs Surgery / adverse effects. Ofloxacin / therapeutic use. Surgical Wound Infection / prevention & control
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Prospective Studies. Wounds and Injuries / drug therapy. Wounds and Injuries / etiology


72. Borba LA, Araújo JC, de Oliveira JG, Filho MG, Moro MS, Tirapelli LF, Colli BO: Surgical management of glomus jugulare tumors: a proposal for approach selection based on tumor relationships with the facial nerve. J Neurosurg; 2010 Jan;112(1):88-98
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  • [Title] Surgical management of glomus jugulare tumors: a proposal for approach selection based on tumor relationships with the facial nerve.
  • OBJECT: The goal of this paper is to analyze the extension and relationships of glomus jugulare tumor with the temporal bone and the results of its surgical treatment aiming at preservation of the facial nerve.
  • Based on the tumor extension and its relationships with the facial nerve, new criteria to be used in the selection of different surgical approaches are proposed.
  • METHODS: Between December 1997 and December 2007, 34 patients (22 female and 12 male) with glomus jugulare tumors were treated.
  • Clinical findings included hearing loss in 88%, swallowing disturbance in 50%, and facial nerve palsy in 41%.
  • Magnetic resonance imaging demonstrated a mass in the jugular foramen in all cases, a mass in the middle ear in 97%, a cervical mass in 85%, and an intradural mass in 41%.
  • The tumor was supplied by the external carotid artery in all cases, the internal carotid artery in 44%, and the vertebral artery in 32%.
  • The infralabyrinthine retrofacial approach (Type A) was used in 32.5%; infralabyrinthine pre- and retrofacial approach without occlusion of the external acoustic meatus (Type B) in 20.5%; infralabyrinthine pre- and retrofacial approach with occlusion of the external acoustic meatus (Type C) in 41%; and the infralabyrinthine approach with transposition of the facial nerve and removal of the middle ear structures (Type D) in 6% of the patients.
  • RESULTS: Radical removal was achieved in 91% of the cases and partial removal in 9%.
  • Six patients (17.6%) had a new lower cranial nerve deficit, but recovery of swallowing function was adequate in all cases.
  • CONCLUSIONS: Radical removal of glomus jugulare tumor can be achieved without anterior transposition of the facial nerve.
  • The extension of dissection, however, should be tailored to each case based on tumor blood supply, preoperative symptoms, and tumor extension.
  • [MeSH-major] Brain Neoplasms / surgery. Facial Nerve. Glomus Jugulare Tumor / surgery. Neurosurgical Procedures / methods

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  • (PMID = 19425885.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Ciocca L, Mingucci R, Bacci G, Scotti R: CAD-CAM construction of an auricular template for craniofacial implant positioning: a novel approach to diagnosis. Eur J Radiol; 2009 Aug;71(2):253-6
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  • [Title] CAD-CAM construction of an auricular template for craniofacial implant positioning: a novel approach to diagnosis.
  • A novel approach to the diagnosis of bone available for craniofacial implant positioning is discussed in a case that required ear ablation for tumor removal.
  • A mirrored volume of the healthy ear was rapidly prototyped for a clinical trial in an appropriate position relative to the patient's face.
  • Three ideal positions for the implant were chosen in the inner of the volume of the mirrored ear.
  • [MeSH-major] Computer-Aided Design. Ear, External / abnormalities. Ear, External / surgery. Prostheses and Implants. Prosthesis Fitting / methods. Surgery, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 18562144.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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74. Ramsden R, Khwaja S, Green K, O'Driscoll M, Mawman D: Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant? Otol Neurotol; 2005 Mar;26(2):261-4
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  • [Title] Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant?
  • OBJECTIVE: To explore the dilemma faced by neurotologists confronted with the patient who develops a vestibular schwannoma in the only hearing ear, the other having been deaf from birth, and to consider the choice between auditory rehabilitation using a cochlear implant (CI) on the congenitally deaf side and an auditory brainstem implant (ABI) on the tumor side.
  • STUDY DESIGN: A record review of two patients born deaf in one ear and who developed a vestibular schwannoma in the contra lateral ear, who then received a CI in the congenitally deaf ear.
  • SETTING: Tertiary referral center with special experience in vestibular schwannoma surgery, neurofibromatosis type 2 management, and cochlear implantation.
  • RESULTS: Neither patient was a good CI user.
  • They scored 54% and 57%, respectively, on City University of New York sentences with lip-reading, and both had fair access to environmental sound scoring at 45% each.
  • CONCLUSIONS: The results from cochlear implantation in the congenitally deaf ear in these patients were poor and suggest that stimulus deprivation in the early stages of the maturation of the auditory pathways is important even for a unilateral hearing loss.
  • In these circumstances, the authors advocate the insertion of an ABI at the time of tumor removal, retaining the option of CI in the congenitally deaf ear in the event of a poor outcome with the ABI.

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  • (PMID = 15793416.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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75. Kobayashi K, Ishihara H, Murakami R, Kinoshita N, Tokunaga K: Total lower eyelid reconstruction with a prefabricated flap using auricular cartilage. J Craniomaxillofac Surg; 2008 Mar;36(2):59-65
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  • [Title] Total lower eyelid reconstruction with a prefabricated flap using auricular cartilage.
  • INTRODUCTION: Various methods have been reported for reconstructing the lower eyelid, but there is still the problem of creating a deep fornix and a supportive eyelid for housing an artificial eye.
  • CASE REPORT: A new prefabricated flap was developed using auricular cartilage and the lateral femoral circumflex vessels as vascular pedicles.
  • This was applied in a 64-year-old male patient with total lower eyelid loss following an extended maxillectomy for tumour.
  • CONCLUSION: The prefabricated flap described here showed more flexibility and a longer vascular pedicle, thus improving the applications for use in patients with limited recipient vessels yet without major sacrifice or deformity in the donor area.
  • [MeSH-major] Blepharoplasty / methods. Ear Cartilage / blood supply. Ear Cartilage / transplantation. Eyelids / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Carcinoma, Squamous Cell / surgery. Eye Enucleation. Eye, Artificial. Humans. Male. Maxillary Neoplasms / surgery. Middle Aged. Oral Surgical Procedures / adverse effects. Orbital Implants. Rectus Abdominis / transplantation

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  • (PMID = 18255303.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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76. Bartoszewicz R, Niemczyk K, Morawski K, Bruzgielewicz A, Sokołowski J: [Lateral petrosectomy in pathology of the temporal bone]. Otolaryngol Pol; 2010 Jun;64(7):81-6
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  • INTRODUCTION: Certain problems in ear surgery are caused by temporal bone cholestetoma and chronic otitis media complicated by deafness, facial nerve dysfunction, vertigo or meningcephalocele.
  • AIM OF STUDY: It is an analysis of indications for lateral petrosectomy and it's results as a treatment of otitis media and temporal bone cholesteatoma.
  • RESULTS: Thirty two patients suffered from chronic granuloma or chronic choleateatoma otitis media or temporal bone cholesteatoma.
  • In one case lateral perosectomy was used as a treatment of CSF leak after removal of cerebellopontine tumor.
  • [MeSH-major] Cochlear Implantation / methods. Ear Diseases / pathology. Ear Diseases / surgery. Petrous Bone / pathology. Petrous Bone / surgery
  • [MeSH-minor] Aged. Cholesteatoma, Middle Ear / pathology. Cochlear Implants. Deafness / etiology. Deafness / surgery. Female. Humans. Male. Middle Aged. Osteoradionecrosis / pathology. Osteoradionecrosis / surgery. Otitis Media / pathology. Otitis Media / surgery. Poland. Retrospective Studies. Treatment Outcome

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  • (PMID = 21171318.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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77. Mahadevaiah A, Parikh B, Kumaraswamy K: Surgical management of glomus tympanicum tumor. Indian J Otolaryngol Head Neck Surg; 2007 Mar;59(1):5-8
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  • [Title] Surgical management of glomus tympanicum tumor.
  • Glomus tympanicum tumor (also known as paraganglioma or chemodectoma) is the most benign tumor of temporal bone.
  • Advances in the imaging and refinements in traditional surgery have made correct diagnosis and complete excision of these tumors possible in most of the cases.

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  • [Cites] Laryngoscope. 1989 Sep;99(9):875-84 [2549310.001]
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  • (PMID = 23120373.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451734
  • [Keywords] NOTNLM ; Glomus tympanicum / open cavity mastoidectomy / post-auricular transcanal tympanotomy (PATT)
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78. Mazlina S, Shiraz MA, Hazim MY, Amran AR, Zulkarnaen AN, Wan Muhaizan WM: Sinonasal inverted papilloma with malignant transformation in the middle ear: a multicentric origin? J Laryngol Otol; 2006 Jul;120(7):597-9
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  • [Title] Sinonasal inverted papilloma with malignant transformation in the middle ear: a multicentric origin?
  • Inverted papilloma is a rare, benign tumour representing only 0.5 to 4 per cent of all sinonasal neoplasms; its involvement of the middle ear is extremely rare.
  • We present a case of multicentric inverted papilloma in the sinonasal region and middle ear in a 54-year-old man.
  • The patient later developed neck metastasis secondary to malignant transformation of the inverted papilloma in the middle ear.
  • [MeSH-major] Ear Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology. Papilloma, Inverted / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic. Ear, Middle / pathology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Multiple Primary / pathology. Tomography, X-Ray Computed

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  • (PMID = 16672089.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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79. Villablanca EJ, Renucci A, Sapède D, Lec V, Soubiran F, Sandoval PC, Dambly-Chaudière C, Ghysen A, Allende ML: Control of cell migration in the zebrafish lateral line: implication of the gene "tumour-associated calcium signal transducer," tacstd. Dev Dyn; 2006 Jun;235(6):1578-88
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  • [Title] Control of cell migration in the zebrafish lateral line: implication of the gene "tumour-associated calcium signal transducer," tacstd.
  • The posterior primordium, which deposits the neuromasts on the body and tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail.
  • Inactivation of the zebrafish tacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for the deposition process.
  • [MeSH-minor] Amino Acid Sequence. Animals. Antigens, Neoplasm / genetics. Cell Adhesion Molecules / genetics. Humans. Molecular Sequence Data

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  • [Copyright] Developmental Dynamics 235:1578-1588, 2006. (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16552761.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human; 0 / Membrane Glycoproteins; 0 / TACSTD2 protein, human; 0 / Tacstd protein, zebrafish; 0 / Zebrafish Proteins
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80. Harada D, Takada C, Nosaka Y, Takashima Y, Kobayashi K, Takaba K, Manabe H: Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int Immunopharmacol; 2009 Jan;9(1):55-62
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  • KF66490 is a newly developed PDE4 inhibitor that inhibits PDE4B (IC(50)=220 nM) and the production of tumor necrosis factor (TNF)-alpha by mouse peritoneal exudated cells stimulated with lipopolysaccharide (IC(50)=855 nM).
  • To evaluate efficacy of KF66490 in atopic dermatitis (AD) models, on skin inflammation induced by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) on ear in BALB/c mice and on spontaneously AD-like skin diseases in NC/Nga mice.
  • BALB/c mice were sensitized with 0.3% w/v TNCB applied to the ear on day-7, followed by application three times a week from days 0 to 21.
  • In the TNCB-induced dermatitis model, KF66490 significantly inhibited the increase in ear thickness and interleukin (IL)-4 and IL-1beta levels in the ear.
  • Histopathological and immunohistochemical analysis revealed that KF66490 significantly inhibited the proliferation of fibroblasts and CD3-positive T cells infiltration into the ear.
  • The present results suggest that KF66490 has excellent potential as an oral medicine for the treatment of atopic dermatitis.
  • [MeSH-major] Cyclohexanecarboxylic Acids / therapeutic use. Dermatitis, Contact / drug therapy. Dioxanes / therapeutic use. Phosphodiesterase 4 Inhibitors. Phosphodiesterase Inhibitors / therapeutic use
  • [MeSH-minor] Administration, Oral. Animals. Anti-Inflammatory Agents / therapeutic use. Body Weight / drug effects. Cytokines / metabolism. Ear, External / metabolism. Ear, External / pathology. Immunoglobulin E / biosynthesis. Immunoglobulin E / metabolism. Immunohistochemistry. Interleukin-1beta / biosynthesis. Interleukin-4 / biosynthesis. Male. Mice. Mice, Inbred BALB C. Picryl Chloride. Prednisolone / therapeutic use. Vomiting / chemically induced

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  • (PMID = 18854230.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid; 0 / Anti-Inflammatory Agents; 0 / Cyclohexanecarboxylic Acids; 0 / Cytokines; 0 / Dioxanes; 0 / Interleukin-1beta; 0 / Phosphodiesterase 4 Inhibitors; 0 / Phosphodiesterase Inhibitors; 207137-56-2 / Interleukin-4; 37341-29-0 / Immunoglobulin E; 9PHQ9Y1OLM / Prednisolone; Z4ZG7O5SZ9 / Picryl Chloride
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81. Viswanatha B: Kimura's disease in children: a 9 years prospective study. Int J Pediatr Otorhinolaryngol; 2007 Oct;71(10):1521-5
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  • [Title] Kimura's disease in children: a 9 years prospective study.
  • Kimura's disease is a rare form of chronic inflammatory disorder involving subcutaneous tissue, predominantly in the head and neck region and frequently associated with lymphadenopathy and/or salivary gland enlargement.
  • The nodular lesions are deep seated in subcutaneous tissue and clinically may mimic a neoplasm.
  • Hence head and neck surgeons need to be aware of clinical presentation of Kimura's disease.
  • OBJECTIVES: To study the clinical presentations, management and complications of Kimura's disease in pediatric age group.
  • RESULTS: All the patients presented with painless swelling in the head and neck region.
  • Post-auricular region was the commonest site (50%).
  • One patient had nephrotic syndrome (5.5%).
  • CONCLUSION: Post-auricular region is the commonest site of involvement.
  • The only systemic complication is nephrotic syndrome.

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  • (PMID = 17586058.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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82. Turgut G, Sacak B, Kiran K, Bas L: Use of rapid prototyping in prosthetic auricular restoration. J Craniofac Surg; 2009 Mar;20(2):321-5
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  • [Title] Use of rapid prototyping in prosthetic auricular restoration.
  • Reconstructing auricular defects is a challenging task for facial reconstructive surgeons.
  • Auricular restorations with facial prosthesis have produced promising results, but there are still problems to be tackled for improved results.
  • Rapid prototyping in the production of an auricular prosthesis uses the mirror image of contralateral ear and produces excellent forms, eliminating the subjective perception of the prosthodontist.
  • Between 2004 and 2007, 10 patients applied to our department with the absence of an ear on a single side.
  • The etiology for the loss of the ear was mostly tumors, followed by congenital deformities and trauma, respectively.
  • [MeSH-major] Computer-Aided Design. Ear, External. Prostheses and Implants. Prosthesis Design
  • [MeSH-minor] Burns / surgery. Child. Ear Neoplasms / rehabilitation. Ear Neoplasms / surgery. Humans. Image Processing, Computer-Assisted. Longitudinal Studies. Magnetic Resonance Imaging. Male. Middle Aged. Osseointegration / physiology. Prosthesis Coloring. Prosthesis Implantation. Tomography, X-Ray Computed. User-Computer Interface. Young Adult

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  • (PMID = 19276832.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Meningaud JP, Bertolus C, Bertrand JC: Parotidectomy: assessment of a surgical technique including facelift incision and SMAS advancement. J Craniomaxillofac Surg; 2006 Jan;34(1):34-7
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  • [Title] Parotidectomy: assessment of a surgical technique including facelift incision and SMAS advancement.
  • In both procedures the posterior branch of the great auricular nerve was not preserved, hence the two procedures were not evaluated regarding sensitivity of the auricle and preauricular area.
  • RESULT: Before parotidectomy, patients were concerned in a decreasing order with the facial nerve function, the scar, the soft-tissue defect in the dorsal part of the cheek and Frey's syndrome.
  • Following use of the classical technique, patients were concerned in decreasing order with the soft-tissue defect, the scar and Frey's syndrome.
  • Following the SMAS technique, no one was concerned with the scar, Frey's syndrome, or the soft tissue defect although a slight asymmetry could still be noticed.
  • CONCLUSION: The SMAS-lifting technique might possibly appear to offer a new standard procedure for parotidectomy, except for malignant tumours or in obese patients.
  • [MeSH-minor] Adult. Aged. Attitude to Health. Cheek / pathology. Cicatrix / etiology. Cicatrix / psychology. Ear, External / innervation. Facial Nerve / physiology. Fascia / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neck Muscles / surgery. Patient Satisfaction. Rhytidoplasty. Sensation / physiology. Surgical Flaps. Sweating, Gustatory / etiology. Sweating, Gustatory / psychology. Treatment Outcome

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  • (PMID = 16343918.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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84. Li G, Chang S, Adler JR Jr, Lim M: Irradiation of glomus jugulare tumors: a historical perspective. Neurosurg Focus; 2007;23(6):E13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Irradiation of glomus jugulare tumors: a historical perspective.
  • Glomus jugulare tumors are rare, slow-growing vascular lesions that arise from the chief cells of the paraganglia within the jugular bulb.
  • They can be associated with the tympanic branch of the glossopharyngeal nerve (Jacobsen nerve) or the auricular branch of the vagus nerve (Arnold nerve) and are also referred to as chemodectomas or nonchromaffin paragangliomas.
  • Optimal treatment of these histologically benign tumors remains controversial.
  • External-beam radiation was originally used for subtotal resections and in patients who were poor surgical candidates; however, radiosurgery has recently been introduced as an effective and safe treatment option for patients with these tumors.
  • In this article the authors discuss the history of radiation therapy for glomus jugulare tumors, focusing on recent radiosurgical results.
  • [MeSH-major] Glomus Jugulare Tumor / radiotherapy. Glomus Jugulare Tumor / surgery. Radiosurgery / history. Radiosurgery / methods

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  • (PMID = 18081478.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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85. Brozek K, Kozakiewicz J, Kierzek A: [Professor Wacław Kuśnierczyk (1908-1997)--Pro Memoria in the century of birthday]. Otolaryngol Pol; 2009 Mar-Apr;63(2):215-8
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  • In 1953 he obtained the title of second degree specialist in ear, nose and throat diseases.
  • Since then this eminent physician was working on tumours located in upper respiratory tract and the possibility of its endoscopic diagnosis at Silesian Academy of Medicine in Katowice.
  • It was Wacław Kuśnierczyk who implemented new priorities for integrated programs in patient care, research, education and cancer prevention.

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  • (PMID = 19681499.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Biography; English Abstract; Historical Article; Journal Article; Portraits
  • [Publication-country] Poland
  • [Personal-name-as-subject] Kuśnierczyk W
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86. García-Quintana A, Martín-Lorenzo P, Suárez de Lezo J, Díaz-Escofet M, Llorens R, Medina A: [Infected left atrial myxoma]. Rev Esp Cardiol; 2005 Nov;58(11):1358-60
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  • [Transliterated title] Mixoma auricular izquierdo infectado.
  • Myxoma is the most common primary tumor of the heart.
  • It is uncommon for these tumors to become infected and, at times, clinical presentation is no different from that of an uninfected myxoma.
  • We describe the case of a 58-year-old woman with a previous pharyngeal infection that developed into infection of a left atrial myxoma and which was complicated by systemic embolism affecting the lower limbs.
  • The tumor was resected and the patient's subsequent clinical evolution was uneventful.
  • [MeSH-major] Heart Neoplasms / complications. Myxoma / complications. Streptococcal Infections / complications. Streptococcus oralis

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  • (PMID = 16324591.001).
  • [ISSN] 0300-8932
  • [Journal-full-title] Revista española de cardiología
  • [ISO-abbreviation] Rev Esp Cardiol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 10
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87. Khafif A: [Recurrent pleomorphic adenoma of the parotid gland]. Harefuah; 2007 Feb;146(2):111-2, 165
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  • Resection of such recurrences is associated with an increased risk of facial nerve injury and a higher incidence of recurrent disease.
  • Resection of the primary tumor with a cuff of normal tissue around it during the primary surgical resection lowers the incidence of such metastases, but even with them, metastases still occur.
  • Intraoperative monitoring of the facial nerve may be of help during these surgical interventions, but the surgeon need not rely on the monitor only, but identify the nerve based on its well known anatomy and use the monitor as another surgical tool for safe removal of the tumor.
  • In these cases, the nerve should be reconstructed with a cable graft (mainly greater auricular or sural) when possible.
  • Radiotherapy is reserved for patients that had multiple recurrences or had massive tumor spillage during their surgical procedure of the recurrent tumor.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery
  • [MeSH-minor] Humans. Neoplasm Metastasis. Recurrence

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  • (PMID = 17352279.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] Israel
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88. Zhang B, Huang HZ, Pan CB, Wang JG, Chen WL, Yang ZH: [Effect analysis of modified radical surgery in tongue cancer at early stages]. Zhonghua Yi Xue Za Zhi; 2007 Sep 25;87(36):2578-80
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  • METHODS: Six patients with early stage squamous cell carcinoma of tongue underwent a procedure of modified radical surgery, in which an inconspicuous incision was used, the external jugular vein, sternocleidomastoid muscle, spino-accessory nerve, and greater auricular nerve were preserved, half of glosso and mouth floor were excised, and the defect was repaired instantly.
  • RESULTS: Compared with classic radical neck dissection, this procedure of modified radical surgery showed an inconspicuous incision and pretty appearance, minor edema on face and neck, better shoulder function, and sensation of auricular skin.
  • The patients showed better oncological safety, pretty appearance of tongue, and better oral function of speech, swallow and mastication.
  • CONCLUSION: This ideal procedure of modified radical surgery in tongue cancer at early stages lessens or avoids destruction of face and neck, shoulder malfunction, numbness of auricular skin, and oral dysfunction of speech, swallow and mastication without impairment on the oncologic safety of the radical surgery, and improves the quality of life of the patients.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neck / surgery. Neck Dissection / methods. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Male. Neoplasm Staging. Treatment Outcome

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  • (PMID = 18067839.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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89. Roh JL, Kim HS, Park CI: Randomized clinical trial comparing partial parotidectomy versus superficial or total parotidectomy. Br J Surg; 2007 Sep;94(9):1081-7
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  • BACKGROUND: In recent decades the treatment of benign parotid tumours has shifted from superficial or total parotidectomy to partial parotidectomy.
  • This study examined whether current surgical techniques improved functional outcomes after surgery for benign parotid tumours.
  • The latter consisted of modified facelift incision, greater auricular nerve preservation, partial parotidectomy and coverage with parotid fascia.
  • RESULTS: The mean duration of operation was 0.7 h shorter and the overall complication rate significantly lower in the functional surgery group.
  • In this group, more patients were satisfied with their scars and facial contours, the auricular nerve sensory recovery rate was high, and transient facial paralysis and Frey's syndrome were infrequent (12 and 6 per cent respectively).
  • There was no tumour recurrence in either group during a mean follow-up of 48 months.
  • CONCLUSION: Compared with conventional procedures, function-preserving surgery for benign parotid tumours improved cosmetic, sensory and salivary functions, and reduced the duration of surgery and operative morbidity.
  • [MeSH-major] Otorhinolaryngologic Surgical Procedures / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery. Patient Satisfaction. Postoperative Complications / prevention & control

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  • [Copyright] Copyright (c) 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 17701949.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
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90. Butman JA, Kim HJ, Baggenstos M, Ammerman JM, Dambrosia J, Patsalides A, Patronas NJ, Oldfield EH, Lonser RR: Mechanisms of morbid hearing loss associated with tumors of the endolymphatic sac in von Hippel-Lindau disease. JAMA; 2007 Jul 4;298(1):41-8
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  • [Title] Mechanisms of morbid hearing loss associated with tumors of the endolymphatic sac in von Hippel-Lindau disease.
  • CONTEXT: Endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and cause irreversible sensorineural hearing loss (SNHL) and vestibulopathy.
  • DESIGN, SETTING, AND PATIENTS: Prospective and serial evaluation of patients with von Hippel-Lindau disease and ELSTs at the National Institutes of Health between May 1990 and December 2006.
  • MAIN OUTCOME MEASURES: Clinical findings and audiologic data were correlated with serial magnetic resonance imaging and computed tomography imaging studies to determine mechanisms underlying audiovestibular dysfunction.
  • RESULTS: Thirty-five patients with von Hippel-Lindau disease and ELSTs in 38 ears (3 bilateral ELSTs) were identified.
  • Tumor invasion of the otic capsule was associated with larger tumors (P = .01) and occurred in 7 ears (18%) causing SNHL (100%).
  • No evidence of otic capsule invasion was present in the remaining 31 ears (82%).
  • Tumor size was not related to SNHL (P = .23) or vestibulopathy (P = .83).
  • CONCLUSIONS: ELST-associated SNHL and vestibulopathy may occur suddenly due to tumor-associated intralabyrinthine hemorrhage, or insidiously, consistent with endolymphatic hydrops.
  • Both of these pathophysiologic mechanisms occur with small tumors that are not associated with otic capsule invasion.

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  • [CommentIn] Arch Otolaryngol Head Neck Surg. 2007 Sep;133(9):857 [17875849.001]
  • (PMID = 17609489.001).
  • [ISSN] 1538-3598
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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91. Cai Z, Jiang H, Guo D: [Reconstruction of contracted eye socket using expanded forehead island skin flap]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2007 Aug;21(8):847-9
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  • The defects were caused by tumors in 2 patients, by trauma in 3, and by chemical burns in 1; the defects were in the left eyes of 4 patients and in the right eyes of the remaining 2 patients, with the illness course of 1 year to 4 years.
  • RESULTS: The follow-up of all the patients for 1-3 years revealed that the skin flaps survived, with no visible contracture, and the fine sensory function was still present.
  • CONCLUSION: Reconstruction of the eye socket with an expanded forehead island skin flap with the supratrochlear and supraorbital arteries is a feasible, effective and simply method, and the patient can have a concealed incision, a satisfactory appearance, and a fine sensory function.
  • [MeSH-minor] Adolescent. Adult. Eye Neoplasms / surgery. Feasibility Studies. Female. Follow-Up Studies. Graft Survival. Humans. Male. Treatment Outcome. Young Adult

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  • (PMID = 17882882.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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92. Devaney KO, Boschman CR, Willard SC, Ferlito A, Rinaldo A: Tumours of the external ear and temporal bone. Lancet Oncol; 2005 Jun;6(6):411-20
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  • [Title] Tumours of the external ear and temporal bone.
  • Symptoms such as hearing impairment, tinnitus, or a disturbance in sense of balance can generally be attributed to non-neoplastic causes, such as otitis media, otosclerosis, or trauma.
  • Less commonly, auricular signs and symptoms are the result of non-neoplastic and neoplastic space-occupying lesions.
  • The external ear can be the site of development of squamous carcinomas and basal-cell carcinomas; the middle ear and inner ear can host metastatic deposits, and primary squamous carcinomas and adenocarcinomas.
  • Most auricular malignant diseases occur in adulthood; only the rhabdomyosarcomas of the middle ear arise in children.
  • Most malignant diseases of the auricular apparatus are treated by a combination of surgery (commonly including radical excision of temporal bone), radiotherapy, and chemotherapy.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear Neoplasms / therapy. Ear, External. Skull Neoplasms / diagnosis. Skull Neoplasms / therapy. Temporal Bone

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  • (PMID = 15925819.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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93. Patel AK, Alexander TH, Andalibi A, Ryan AF, Doherty JK: Vestibular schwannoma quantitative polymerase chain reaction expression of estrogen and progesterone receptors. Laryngoscope; 2008 Aug;118(8):1458-63
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  • OBJECTIVES/HYPOTHESIS: Determine the role of estrogen receptor (ER) and progesterone receptor (PR) expression in sporadic and neurofibromatosis 2 (NF2)-related vestibular schwannomas (VS).
  • Growth and proliferation signaling in human VS tumorigenesis may play a key role in molecular therapeutic targeting.
  • VS carry mutations of the NF2 gene encoding the tumor suppressor, merlin, which interacts with ErbB2 in Schwann cells, implicating ErbB receptors in VS tumorigenesis.
  • ErbB receptor family members are overexpressed or constitutively activated in many human tumors, and are effective therapeutic targets in some human cancers.
  • VS occur more frequently in women and are larger, more vascular, and demonstrate increased growth rates during pregnancy.
  • ER and PR may play a role in ErbB pathway activation and VS progression.
  • STUDY DESIGN: Quantitative real-time polymerase chain reaction (qRT-PCR) for ER and PR messenger RNA was performed using greater auricular and vestibular nerve controls (n = 8), sporadic VS (n = 23), and NF2-related VS (n = 16) tissues.
  • RESULTS: Reverse transcription of messenger RNA from control and tumor specimens followed by RT Q-PCR demonstrated differences in ER and PR gene expression between sporadic and NF2-related vs.
  • CONCLUSIONS: ER and PR expression in VS might have implications for development of a VS-specific drug delivery system using antihormone and ErbB pathway small molecule inhibitors, due to crosstalk between these receptors.
  • These signals may be critical for re-establishing ErbB-mediated cell density dependent growth inhibition.
  • [MeSH-major] Ear Neoplasms / metabolism. Neuroma, Acoustic / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Vestibule, Labyrinth / metabolism

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  • (PMID = 18670322.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / BLRD VA / BX / I01 BX001205; United States / NIDCD NIH HHS / DC / T32 DC000028
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ NIHMS438693; NLM/ PMC3570025
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94. Lee SH, Jang YH, Tae K, Park YW, Kang MJ, Kim KR, Park CW: Telomerase activity and cell proliferation index in cholesteatoma. Acta Otolaryngol; 2005 Jul;125(7):707-12
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  • OBJECTIVE: Telomerase activity is detected in most malignant tumors and is also known to have a close relationship with cell proliferation.
  • We studied telomerase activity in cholesteatoma and its relationship with cellular proliferation and clinical findings.
  • MATERIAL AND METHODS: Cholesteatoma tissue was obtained from 40 patients during middle ear surgery.
  • Posterior auricular skin was used as a control.
  • RESULTS: Telomerase activity was positive in 21/40 cholesteatomas (52.5%), but absent in the control group.
  • [MeSH-major] Cell Proliferation. Cholesteatoma, Middle Ear / enzymology. Telomerase / metabolism

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  • (PMID = 16012031.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Ki-67 Antigen; EC 2.7.7.49 / Telomerase
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95. Clark RR, Soutar DS: Lymph node metastases from auricular squamous cell carcinoma. A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg; 2008 Oct;61(10):1140-7
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  • [Title] Lymph node metastases from auricular squamous cell carcinoma. A systematic review and meta-analysis.
  • INTRODUCTION: Squamous cell carcinoma arising on the auricle is believed to metastasise to the regional lymph nodes more frequently than comparable tumours at other sites.
  • Metastatic spread of these tumours is associated with a poor outcome but there is no clear consensus of opinion on how to identify patients at risk of metastatic spread and treat them.
  • RESULTS: The metastatic rate is 11.2% with spread to the parotid and upper deep cervical chain most common.
  • Depth of invasion, tumour size, degree of cellular differentiation and incomplete primary excision margins may be useful in identifying lesions most at risk of metastasising but there is insufficient evidence at present to allow targeted neck dissections.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Ear Auricle. Ear Neoplasms / epidemiology

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  • (PMID = 18675609.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 62
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96. Vankalakunti M, Das A, Rao NK: Postauricular congenital alveolar rhabdomyosarcoma- a case report of an unusual entity. Diagn Pathol; 2006;1:37
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  • BACKGROUND: Congenital alveolar rhabdomyosarcoma is an extremely uncommon and invariably fatal tumor with the current therapy.
  • CASE PRESENTATION: We report a case of congenital alveolar rhabdomyosarcoma in an 18-month-old male who presented with a progressively increasing mass lesion in the left post-auricular region since birth.
  • Upon resecting the mass that was 10-cm in largest dimension, the gross, microscopic, and ultrastructural findings were consistent with congenital alveolar rhabdomyosarcoma.
  • CONCLUSION: The suspicion of alveolar subtype on histological grounds and proper evaluation of this tumor by immunostain and ultrastuctural examination is necessary.

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  • (PMID = 17044930.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1621081
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97. Ghosh SK, Bandyopadhyay D, Gupta S, Chatterjee G, Ghosh A: Rapidly growing extraocular sebaceous carcinoma occurring during pregnancy: a case report. Dermatol Online J; 2008;14(8):8
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  • Sebaceous carcinoma is a very rare, aggressive, malignant tumor derived from the adnexal epithelium of sebaceous glands.
  • It is traditionally classified into two groups: tumors arising from the ocular adnexa and those arising in extra-ocular sites.
  • Extraocular sebaceous carcinoma in the post-auricular region or in the external auditory canal is very rarely described in the literature.
  • A case of a rapidly growing sebaceous carcinoma of the pinna occurring in a pregnant woman is reported here for its rarity.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Ear Neoplasms / pathology. Ear, External / pathology. Pregnancy Complications, Neoplastic / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Pregnancy

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  • (PMID = 19061568.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Crew KD, Capodice JL, Greenlee H, Brafman L, Fuentes D, Awad D, Yann Tsai W, Hershman DL: Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. J Clin Oncol; 2010 Mar 1;28(7):1154-60
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  • TA included full body/auricular acupuncture and joint-specific point prescriptions, whereas SA involved superficial needle insertion at nonacupoint locations.
  • Results Of 51 women enrolled, 43 women were randomly assigned and 38 were evaluable.
  • Similar findings were seen for the WOMAC and M-SACRAH scores.
  • [MeSH-major] Acupuncture Therapy. Aromatase Inhibitors / adverse effects. Arthralgia / therapy. Breast Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 20100963.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aromatase Inhibitors
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99. Lo WC, Ting LL, Ko JY, Lou PJ, Yang TL, Chang YL, Wang CP: Malignancies of the ear in irradiated patients of nasopharyngeal carcinoma. Laryngoscope; 2008 Dec;118(12):2151-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignancies of the ear in irradiated patients of nasopharyngeal carcinoma.
  • OBJECTIVES/HYPOTHESIS: To report on the clinical profiles and treatment experiences of patients with second primary ear malignancy after treatment of nasopharyngeal carcinoma (NPC).
  • METHODS: A retrospective review of the clinical outcomes and pathology of 11 irradiated NPC patients who subsequently had second primary malignancies of the ear at a single institution.
  • RESULTS: Ten tumors were squamous cell carcinoma and one tumor was chondrosarcoma occurring within the radiation field of previous treatment for NPC.
  • The interval between previous radiotherapy and diagnosis of ear malignancy was 3 to 27 years with a median time of 17 years.
  • Six tumors were located in the external auditory canal, two in the middle ear cavity, two in the periauricular region and one in the mastoid cavity.
  • The 3-year disease-free and overall survival rates were 30.3% and 20%, respectively.
  • CONCLUSIONS: Postirradiated malignancy of the ear is extremely rare, but is one of the causes of death for NPC long-term survivors despite curative-intended treatment with surgery plus adjuvant radiotherapy is instituted.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Chondrosarcoma / etiology. Ear Neoplasms / etiology. Nasopharyngeal Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies

  • Genetic Alliance. consumer health - Nasopharyngeal carcinoma.
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  • (PMID = 18948828.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Hu J, Ye W, Zheng J, Zhu H, Zhang Z: The feasibility and significance of preservation of the lobular branch of the great auricular nerve in parotidectomy. Int J Oral Maxillofac Surg; 2010 Jul;39(7):684-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The feasibility and significance of preservation of the lobular branch of the great auricular nerve in parotidectomy.
  • This study was designed to evaluate the feasibility and significance of preserving the lobular branch of the great auricular nerve (GAN) during parotidectomy.
  • Ninety-three patients with benign tumour undergoing parotidectomy were separated randomly into three groups.
  • Thirty-one patients underwent a parotidectomy with the main trunk of GAN sacrificed (group A), 29 patients had the posterior-auricular branch preserved (group B), and 33 patients had the lobular branch preserved (group C).
  • These results demonstrate that preservation of the lobular branch of GAN is technically feasible during parotidectomy.
  • [MeSH-major] Parotid Gland / innervation. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20413273.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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