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1. Sapundzhiev N, Dünne AA, Ramaswamy A, Werner JA: The auricular VX2 carcinoma: feasibility of complete tumor resection. Anticancer Res; 2005 Nov-Dec;25(6B):4209-14
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The auricular VX2 carcinoma: feasibility of complete tumor resection.
  • BACKGROUND: The aim of the study was to test the feasibility of resection of VX2 auricular squamous cell carcinoma (SCC) in New Zealand White rabbits (NZW), its influence on the regional and distant metastases and the general prognosis.
  • MATERIALS AND METHODS: In 71 NZW rabbits, successful in sano wide margin resection of auricular VX2 SCC was performed 7 days after tumor induction.
  • RESULTS: Local recurrences occured in 7% of the animals.
  • Local control and LN involvement were found to be important prognostic factors for early tumor-related death.
  • CONCLUSION: The VX2 auricular model resembles head and neck (HN) SCC in humans morphologically, pathophysiologically and as a complex neoplastic disease.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Ear Neoplasms / surgery
  • [MeSH-minor] Animals. Disease Models, Animal. Ear, External / pathology. Ear, External / surgery. Neoplasm Metastasis. Rabbits

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 16309218.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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2. Bahadir O, Livaoglu M, Ural A: Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy. Indian J Plast Surg; 2008 Jul;41(2):201-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy.
  • Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor.
  • Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor.
  • Grafting material for the facial reconstruction was harvested from the great auricular nerve.
  • The proximal main trunk and each distal branch of the facial nerve were coapted with the greater auricular nerve.
  • Thus, the great auricular nerve is appropriate grafting material for coaptation of each distal branch of the facial nerve.

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  • (PMID = 19753265.001).
  • [ISSN] 0970-0358
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2740500
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / facial nerve reconstruction / parotid gland / radiotherapy
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3. Elbayoumi TA, Torchilin VP: Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice. Int J Pharm; 2008 Jun 5;357(1-2):272-9
Hazardous Substances Data Bank. DOXORUBICIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice.
  • A mucocutaneous reaction in mice associated with Doxil treatment was identified as auricular erythema (AE).
  • Given that the immuno-targeting of Doxil to tumors was found to influence also its systemic biodistribution pattern, the attempt was made to exploit a specific targeting of Doxil to reduce the manifestation of this adverse reaction.
  • Tumor-bearing mice were used to study the biodistribution and skin-tissue accumulation effects of the tumor-targeted Doxil (the clinically used anti-cancer formulation) coupled with the anti-cancer monoclonal 2C5 antibody (mAb 2C5) as well as AE caused by Doxil application.
  • The modification of Doxil with mAb 2C5 resulted in a significant decrease in the normal skin accumulation of doxorubicin compared to original Doxil and substantially reduced AE.
  • Thus, targeting of Doxil with the anti-cancer mAb 2C5 not only can increase the tumor-specific accumulation of the drug, but also diminishes the cutaneous side effect of the original Doxil therapy.

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  • (PMID = 18329201.001).
  • [ISSN] 0378-5173
  • [Journal-full-title] International journal of pharmaceutics
  • [ISO-abbreviation] Int J Pharm
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL055519-12; United States / NHLBI NIH HHS / HL / R01 HL055519; United States / NHLBI NIH HHS / HL / R01 HL055519-12; United States / NHLBI NIH HHS / HL / R01 HL55519
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antibodies, Monoclonal; 0 / Indium Radioisotopes; 0 / Liposomes; 0 / Pharmaceutical Vehicles; 30IQX730WE / Polyethylene Glycols; 80168379AG / Doxorubicin
  • [Other-IDs] NLM/ NIHMS51910; NLM/ PMC2680692
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4. Schmid DW, Di Summa PG, Wettstein R, Erba P, Wassim R, Kalbermatten DF: Posterior auricular perichondrial cutaneous graft combined with cartilage strip in nostril reconstruction. Eplasty; 2008;8:e42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Posterior auricular perichondrial cutaneous graft combined with cartilage strip in nostril reconstruction.
  • METHOD: A perichondrial cutaneous graft (PCCG), a graft consisting of a perichondral layer, fatty tissue, and skin that is harvested retroauriculary, is combined with an attached cartilage strip.
  • CONCLUSION: First, a strip of cartilage had been included in a PCCG where tumor resection required sacrifice of more than 50% of the alar rim.

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  • (PMID = 18806870.001).
  • [ISSN] 1937-5719
  • [Journal-full-title] Eplasty
  • [ISO-abbreviation] Eplasty
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2519965
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5. Mailler-Savage EA, Neal KW Jr, Godsey T, Adams BB, Gloster HM Jr: Is levofloxacin necessary to prevent postoperative infections of auricular second-intention wounds? Dermatol Surg; 2008 Jan;34(1):26-30; discussion 30-1
Hazardous Substances Data Bank. Ofloxacin .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is levofloxacin necessary to prevent postoperative infections of auricular second-intention wounds?
  • BACKGROUND: Surgeons may prescribe oral quinolones after auricular procedures to prevent postoperative infections, especially those caused by Pseudomonas aeruginosa.
  • OBJECTIVE: This study compares the efficacy of levofloxacin and local wound care to local wound care alone in preventing postoperative infection of auricular second-intention wounds.
  • MATERIALS AND METHODS: This study was a prospective, randomized trial of 84 consecutive patients (82 in the final analysis) who underwent Mohs micrographic surgery for an auricular neoplasm and had a wound left to heal by second intention.
  • RESULTS: Overall, 85.4% of patients had no complications.
  • CONCLUSION: Levofloxacin is not necessary to prevent postoperative infections of auricular second-intention wounds after Mohs surgery.
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Ear Auricle / surgery. Levofloxacin. Mohs Surgery / adverse effects. Ofloxacin / therapeutic use. Surgical Wound Infection / prevention & control
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Prospective Studies. Wounds and Injuries / drug therapy. Wounds and Injuries / etiology


6. Tarkowski M, Vanoirbeek JA, Vanhooren HM, De Vooght V, Mercier CM, Ceuppens J, Nemery B, Hoet PH: Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate. Am J Physiol Lung Cell Mol Physiol; 2007 Jan;292(1):L207-14
Hazardous Substances Data Bank. 2,4-TOLUENE DIISOCYANATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BALB/c and severe combined immunodeficiency disease (SCID) mice received toluene diisocyanate (TDI) or vehicle on each ear on day 1 and/or day 7.
  • Tumor necrosis factor-alpha and macrophage inflammatory protein (MIP)-2 levels were measured in BAL.
  • Immunological parameters included total IgE, IgG1, and IgG2a in serum, lymphocyte populations in auricular and cervical lymph nodes, and IL-4 and IFN-gamma levels in supernatants of lymph node cells, cultured with or without concanavalin A.
  • In BALB/c mice an increased level of CD19+ B cells was found in the auricular lymph nodes.
  • IL-4 and IFN-gamma levels were increased in supernatants of concanavalin A-stimulated auricular lymph node cells from BALB/c mice completely treated with TDI.
  • These results indicate that our model is dependent on the presence of lymphocytes, but it is not characterized by a preferential stimulation of Th1 or Th2 lymphocytes.
  • [MeSH-major] Airway Resistance / drug effects. Airway Resistance / immunology. Skin / drug effects. Skin / immunology. Toluene 2,4-Diisocyanate / immunology. Toluene 2,4-Diisocyanate / toxicity
  • [MeSH-minor] Animals. Asthma / chemically induced. Asthma / physiopathology. Bronchoalveolar Lavage Fluid / cytology. Bronchoalveolar Lavage Fluid / immunology. Cytokines / biosynthesis. Disease Models, Animal. Immunoglobulins / blood. In Vitro Techniques. Lymphocytes / drug effects. Lymphocytes / immunology. Male. Methacholine Chloride / pharmacology. Mice. Mice, Inbred BALB C. Mice, SCID

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  • (PMID = 16963530.001).
  • [ISSN] 1040-0605
  • [Journal-full-title] American journal of physiology. Lung cellular and molecular physiology
  • [ISO-abbreviation] Am. J. Physiol. Lung Cell Mol. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Immunoglobulins; 0W5ETF9M2K / Methacholine Chloride; 17X7AFZ1GH / Toluene 2,4-Diisocyanate
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7. Radi ZA: Auricular rhabdomyosarcoma in a rat. J Vet Med A Physiol Pathol Clin Med; 2006 Jun;53(5):246-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auricular rhabdomyosarcoma in a rat.
  • An ear (auricular) neoplasm from a 1-year-old male rat was removed surgically and examined histologically.
  • Macroscopically, the neoplasm was firm, white and measured (0.5 x 0.5 cm).
  • Microscopically, the neoplasm was expansile, non-encapsulated, and composed of large, pleomorphic, polygonal to spindle-shaped cells containing multiple nuclei.
  • Using immunohistochemical and chemical stains, the neoplastic cells were positive for vimentin, myoglobin, phosphotungstic acid haematoxylin and desmin, but had no immunoreactivity for cytokeratin or alpha-smooth muscle actin.
  • On the basis of histopathological, immunohistochemical and histochemical stains, a diagnosis of auricular rhabdomyosarcoma was made.
  • Although reported infrequently in human, this is, to the author's knowledge, the first report that describes the detailed gross, histopathological, histochemical and immunohistochemical findings of auricular rhabdomyosarcoma in a rat.
  • [MeSH-major] Ear Neoplasms / veterinary. Rats, Sprague-Dawley. Rhabdomyosarcoma / veterinary. Rodent Diseases / pathology

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  • (PMID = 16737514.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Zhao HW, Li LJ, Han B, Liu H, Pan J: [A retrospective study on the complications after modified parotidectomy in benign tumors of parotid gland]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2005 Feb;23(1):53-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A retrospective study on the complications after modified parotidectomy in benign tumors of parotid gland].
  • OBJECTIVE: A retrospective clinic study is presented of surgical patients undergoing a modified parotidectomy with conserving the sub-superficial musculoaponeurotic system (sub-SMAS) and great auricular nerve and reconstructing by the stemocleidomastoid flap (SF).
  • The surgical technique was described and the incidence of clinical Frey's syndrome was evaluated by minor test (starch-iodine test) and observed gustatory sweating syndrome.
  • The feeling and concave of the region of auricular lobule were followed up.
  • RESULTS: The incidence of Frey's syndrome in group 1 (5.32%) or group 2 (4.76%) was significantly lower than that of group 3 (49.1%) or group 4 (51.5%) through by subjective observation and minor test (P < 0.005).
  • The significance between group with SF and group without SF existed in protecting the concave of the region of auricular lobule (P < 0.05).
  • The feeling of the region of auricular lobule had no change by preserving the great auricular nerve.
  • CONCLUSION: There was good effect to prevent gustatory sweating syndrome in parotidectomy of reserve parotid fascia.
  • The aesthetics and sense of the region of auricular lobule could be prevented by using SF and reserving the great auricular nerve.
  • [MeSH-minor] Face. Female. Humans. Male. Middle Aged. Neoplasms. Reconstructive Surgical Procedures. Retrospective Studies. Surgical Flaps. Sweating, Gustatory

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  • (PMID = 15804023.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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9. McRae MC, Au A, Narayan D: A novel method of auricular reconstruction. Ann Plast Surg; 2009 May;62(5):554-5
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel method of auricular reconstruction.
  • Seven male patients and 8 total ears underwent composite excision for neoplasm of the auricular helix.
  • An incision at the root of the helix released the superior auricular muscle and a portion of the strong supporting anterior auricular tendon.
  • The cupping deformity was avoided by trimming the concha in a wedge excision.
  • This technique represents an alternative method of single stage reconstruction of the auricular helix.
  • [MeSH-major] Ear, External / surgery. Reconstructive Surgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Ear Neoplasms / surgery. Esthetics. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasms, Second Primary / surgery. Suture Techniques

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  • (PMID = 19387160.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Saussez S, Mahillon V, Blaivie C, Haller A, Chantrain G, Thill MP: Aggressive pilomatrixoma of the infra-auricular area: a case report. Auris Nasus Larynx; 2005 Dec;32(4):407-10
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive pilomatrixoma of the infra-auricular area: a case report.
  • Although pilomatrixomas are well known among dermatologists and dermatopathologists, head and neck surgeons confronted with these lesions in the infra-auricular region do not consider this benign neoplasm in the differential diagnosis.
  • Aggressive pilomatrixoma is a benign tumor of the hair matrix cells affecting mainly children.
  • We report the case of a 15-year-old Turkish boy suffering from an aggressive pilomatrixoma of the infra-auricular region and review the literature about this unclear entity.
  • [MeSH-major] Ear Neoplasms / pathology. Hair Diseases / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Male. Neoplasm Staging

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  • (PMID = 16198080.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 13
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11. Federspil PA: Auricular prostheses. Adv Otorhinolaryngol; 2010;68:65-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auricular prostheses.
  • An auricular prosthesis is an artificial substitute for the auricle; the term epithesis is used synonymously.
  • Advantages of implant-retained auricular prostheses include: optimal camouflage, predictable cosmetic results, fast rehabilitation, no donor site morbidity and early detection of tumor recurrence.
  • [MeSH-major] Ear Auricle. Prostheses and Implants

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20442562.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Silicon Compounds
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12. Demir N, Malkoc MA, Ozturk AN, Tosun Z: Implant-retained auricular prosthesis. J Craniofac Surg; 2010 Nov;21(6):1795-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Implant-retained auricular prosthesis.
  • Auricular defects may result from congenital malformations, injuries from motor vehicle crashes, trauma, or tumor resections.
  • An auricular prosthesis was fabricated for a patient who had an injury from a motor vehicle crash.
  • Extraoral implants and bar-and-clip retention for the proper connection of the auricular prosthesis to implant were used.
  • [MeSH-major] Ear, External. Prostheses and Implants. Prosthesis Design

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  • (PMID = 21119423.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Silicone Elastomers; 0 / cosmesil
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13. Mahalingam M, Kveaton JF, Bhawan J: Cutaneous neuroendocrine adenoma: an uncommon neoplasm. J Cutan Pathol; 2006 Apr;33(4):315-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous neuroendocrine adenoma: an uncommon neoplasm.
  • BACKGROUND: Cutaneous neuroendocrine neoplasms are typically malignant.
  • Benign cutaneous neuroendocrine tumors are uncommon.
  • METHODS: We report the case of a 32-year-old female who presented with a granular mass in the right external auditory canal.
  • RESULTS: Microscopic examination of a shave biopsy revealed a poorly circumscribed neoplasm with glandular differentiation.
  • CONCLUSIONS: This case report of neuroendocrine adenoma indicates that this entity should be entertained in the repertoire of conditions affecting the external ear.
  • [MeSH-major] Ear Canal. Neuroendocrine Tumors / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Ear Neoplasms / diagnosis. Ear Neoplasms / surgery. Female. Humans. Immunohistochemistry

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  • (PMID = 16630184.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Turgut G, Sacak B, Kiran K, Bas L: Use of rapid prototyping in prosthetic auricular restoration. J Craniofac Surg; 2009 Mar;20(2):321-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of rapid prototyping in prosthetic auricular restoration.
  • Reconstructing auricular defects is a challenging task for facial reconstructive surgeons.
  • Auricular restorations with facial prosthesis have produced promising results, but there are still problems to be tackled for improved results.
  • Rapid prototyping in the production of an auricular prosthesis uses the mirror image of contralateral ear and produces excellent forms, eliminating the subjective perception of the prosthodontist.
  • Between 2004 and 2007, 10 patients applied to our department with the absence of an ear on a single side.
  • The etiology for the loss of the ear was mostly tumors, followed by congenital deformities and trauma, respectively.
  • [MeSH-major] Computer-Aided Design. Ear, External. Prostheses and Implants. Prosthesis Design
  • [MeSH-minor] Burns / surgery. Child. Ear Neoplasms / rehabilitation. Ear Neoplasms / surgery. Humans. Image Processing, Computer-Assisted. Longitudinal Studies. Magnetic Resonance Imaging. Male. Middle Aged. Osseointegration / physiology. Prosthesis Coloring. Prosthesis Implantation. Tomography, X-Ray Computed. User-Computer Interface. Young Adult

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  • (PMID = 19276832.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Osborne RF, Shaw T, Zandifar H, Kraus D: Elective parotidectomy in the management of advanced auricular malignancies. Laryngoscope; 2008 Dec;118(12):2139-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elective parotidectomy in the management of advanced auricular malignancies.
  • OBJECTIVE: The purpose of this study is to determine whether elective parotidectomy is necessary in patients with clinically and radiographically N0 parotid disease with isolated primary auricular nonmelanoma cutaneous malignancies.
  • Auricular malignancies are typically managed by wedge resection or wide local excision.
  • Although small lesions are easily managed by conservative excision, large bulky tumors, those with multifocal involvement, and recalcitrant lesions, often require more extensive resection including total auriculectomy, parotidectomy, and/or neck dissection.
  • Patients with a clinical history of advanced nonmelanoma auricular carcinoma undergoing elective parotidectomy and/or neck dissection with clinically and radiographically N0 nodal disease were evaluated for the presence of occult parotid metastasis.
  • All patients underwent parotidectomy in conjunction with a total auriculectomy for surgical extirpation of their primary auricular carcinoma.
  • Parotid specimens were evaluated for histopathologic evidence of metastatic neoplastic disease.
  • RESULTS: Pathological examination showed no histological evidence of occult parotid metastasis in all 19 patients who underwent elective parotidectomy in the presence of clinically and radiographically N0 nodal disease of the parotid or cervical regions.
  • CONCLUSIONS: Parotidectomy may not be necessary in the surgical management of advanced auricularcarcinoma in the absence of clinically positive parotid disease or external auditory canal involvement.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Ear Neoplasms / surgery. Ear, External. Elective Surgical Procedures. Parotid Gland / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Ear Canal / pathology. Female. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Parotid Neoplasms / pathology. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery. Retrospective Studies. Risk Factors

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  • (PMID = 19029866.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Ol'shanskiĭ MS, Korotkikh NG, Shcherbinin AS, Stepanov IV: [Combined treatment of auricular vascular neoplasms]. Vestn Otorinolaringol; 2008;(5):48-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combined treatment of auricular vascular neoplasms].
  • Two cases of combined treatment of auricular vascular neoplasms (arteriovenous malformation and hemangioma) are presented.
  • Their two-step management included endovascular microembolization of the posterior auricular artery with polyvinyl alcohol (PVA 300, 500 mcm) and surgical resection of the tumour.
  • The results confirm the feasibility of combination of traditional and endovascular surgery for the treatment of this pathology.
  • Embolization of the posterior auricular artery can be performed only after the comprehensive angiographic evaluation of the blood flow in angiodysplasia and the adjacent vessels using superselective catheterization and officinal emboli.
  • [MeSH-major] Ear Auricle. Ear Neoplasms / therapy. Embolization, Therapeutic / methods. Hemangioma, Capillary / therapy. Otologic Surgical Procedures / methods

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  • (PMID = 19008842.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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17. Kitagaki M, Hirota M: Auricular chondritis caused by metal ear tagging in C57BL/6 mice. Vet Pathol; 2007 Jul;44(4):458-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auricular chondritis caused by metal ear tagging in C57BL/6 mice.
  • Although it has been shown that auricular chondritis in rats is caused by the use of metal identification ear tags, the pathogenesis remains unclear.
  • Based on the hypothesis that the auricular chondritis is caused by metal ions released from metal identification ear tags, we investigated the pathogenesis in male C57BL/6 mice tagged with metal identification ear tags.
  • Twenty-six weeks after the attachment of the ear tags, visible increases in the thickness of the auricle were observed, and the concentrations of copper and iron in the tagged ears were significantly increased (P < .05) in the tagged ears compared with the untagged ears.
  • Histopathologically, there were observed severe chondritis with extensive granulomatous inflammation, newly formed cartilage nodules, and osseous metaplasia accompanied by cellular infiltrates, such as CD4 T lymphocyte, macrophages, neutrophils, and mast cells, and expression of Th1 cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2 in the tagged ear.
  • Based on these results, we concluded that the release of copper and iron ions from the metal ear tags played a major role in the onset of auricular chondritis.
  • Subsequent cellular interactions, such as CD4 T cells, macrophages, fibroblasts, and mast cells, mediated by cytokines, such as tumor necrosis factor-alpha and interferon-gamma, caused an autoimmune response that may have led to the progression of auricular chondritis as an autoimmune disease.
  • [MeSH-major] Animal Identification Systems. Cartilage Diseases / veterinary. Ear Diseases / veterinary. Metals / adverse effects

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  • (PMID = 17606507.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Metals; 9038-94-2 / Metallothionein
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18. Bernateck M, Becker M, Schwake C, Hoy L, Passie T, Parlesak A, Fischer MJ, Fink M, Karst M: Adjuvant auricular electroacupuncture and autogenic training in rheumatoid arthritis: a randomized controlled trial. Auricular acupuncture and autogenic training in rheumatoid arthritis. Forsch Komplementmed; 2008 Aug;15(4):187-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adjuvant auricular electroacupuncture and autogenic training in rheumatoid arthritis: a randomized controlled trial. Auricular acupuncture and autogenic training in rheumatoid arthritis.
  • OBJECTIVE: The efficacy of auricular electroacupuncture (EA) was directly compared with autogenic training (AT).
  • Primary outcome measures were the mean weekly pain intensity and the disease activity score 28 (DAS 28); secondary outcome measures were the use of pain medication, the pain disability index (PDI), the clinical global impression (CGI) and pro-inflammatory cytokine levels, which were assessed during the study period and 3 months after the end of treatment.
  • RESULTS: At the end of the treatment and at 3-month follow-up a clinically meaningful and statistically significant improvement (p < 0.05) could be observed in all outcome parameters and both groups.
  • The erythrocyte sedimentation rate in the EA group was significantly reduced (p = 0.010), and the serum concentration of tumor necrosis factor-alpha was significantly increased compared to the AT group (p = 0.020).
  • The treatment effects of auricular EA were more pronounced.
  • [MeSH-major] Acupuncture, Ear / methods. Arthritis, Rheumatoid / therapy. Autogenic Training. Electroacupuncture / methods

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  • [Copyright] Copyright (c) 2008 S. Karger AG, Basel.
  • [CommentIn] Forsch Komplementmed. 2008 Oct;15(5):286; author reply 286 [19009726.001]
  • (PMID = 18787327.001).
  • [ISSN] 1661-4127
  • [Journal-full-title] Forschende Komplementärmedizin (2006)
  • [ISO-abbreviation] Forsch Komplementmed
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Switzerland
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19. Lee MW, Nam SY, Choi HJ, Choi JH, Moon KC, Koh JK: Myoepithelioma of parotid gland presenting as infra-auricular subcutaneous mass. J Cutan Pathol; 2005 Mar;32(3):240-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myoepithelioma of parotid gland presenting as infra-auricular subcutaneous mass.
  • Myoepithelioma is a rare but well-characterized group of tumours, among which myoepithelioma of the salivary glands is the best known.
  • We report two patients with myoepithelioma of parotid gland presenting as infra-auricular subcutaneous mass.
  • The lesions were clinically suspected to be epidermal cyst.
  • The biopsies revealed that most of the tumour cells showed epithelioid features with oval or spindle eosinophilic cytoplasm.
  • The tumour cells showed cytoplasmic immunoexpressions of vimentin, cytokeratin (AE1/AE3), S-100 protein and smooth muscle actin (SMA).
  • Myoepithelioma of parotid gland can be presented as a slowly growing tumour of pre- or infra-auricular area.
  • In dermatologic department, it can be misdiagnosed as various dermal or subcutaneous tumours.
  • [MeSH-major] Myoepithelioma / pathology. Parotid Neoplasms / pathology. Soft Tissue Neoplasms / diagnosis. Subcutaneous Tissue / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Keratins / metabolism. Male. Middle Aged. S100 Proteins / metabolism. Vimentin / metabolism

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  • (PMID = 15701087.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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20. Ye XH, Gao L, Li H, Xie L, Hu Y, Bu CB: [Significance of preserving the posterior branch of the great auricular nerve in parotid surgery]. Zhonghua Zheng Xing Wai Ke Za Zhi; 2007 Sep;23(5):385-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Significance of preserving the posterior branch of the great auricular nerve in parotid surgery].
  • OBJECTIVE: To investigate the feasibility, technique and significance of preserving the posterior branch of the great auricular nerve in parotid surgery.
  • METHODS: 48 cases with parotid tumor who underwent regular parotid surgery with cosmetic incision were included.
  • The sensory testing was carried out in upper auricle, lobule, infra-auricular, pre-auricular and post-auricular region preoperatively and at 10 days, 1 month, 6 months and 12 months after operation.
  • RESULTS: The posterior branch of the great auricular nerve was preserved in 35 out of 48 patients.
  • There was no sensory loss in the upper auricle and post-auricular region.
  • Early after operation, sensory disturbance was found in lobule, infra-auricular region, but significantly in pre-auricular region.
  • 13 cases with sacrifice of the nerve had a significantly higher sensory disturbance and a longer recovery time.
  • CONCLUSIONS: Preservation of the posterior branch of the great auricular nerve during parotid surgery is technically feasible and can reduce the postoperative sensory disturbance and possible permanent sensory loss.
  • [MeSH-major] Parotid Gland / innervation. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Ear, External / innervation. Female. Humans. Male. Middle Aged. Postoperative Complications / prevention & control. Young Adult

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  • (PMID = 18161349.001).
  • [ISSN] 1009-4598
  • [Journal-full-title] Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
  • [ISO-abbreviation] Zhonghua Zheng Xing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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21. Hu J, Ye W, Zheng J, Zhu H, Zhang Z: The feasibility and significance of preservation of the lobular branch of the great auricular nerve in parotidectomy. Int J Oral Maxillofac Surg; 2010 Jul;39(7):684-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The feasibility and significance of preservation of the lobular branch of the great auricular nerve in parotidectomy.
  • This study was designed to evaluate the feasibility and significance of preserving the lobular branch of the great auricular nerve (GAN) during parotidectomy.
  • Ninety-three patients with benign tumour undergoing parotidectomy were separated randomly into three groups.
  • Thirty-one patients underwent a parotidectomy with the main trunk of GAN sacrificed (group A), 29 patients had the posterior-auricular branch preserved (group B), and 33 patients had the lobular branch preserved (group C).
  • These results demonstrate that preservation of the lobular branch of GAN is technically feasible during parotidectomy.
  • [MeSH-major] Parotid Gland / innervation. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20413273.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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22. Lu L, Ding Y, Lin Y, Xu Z, Li Z, Qu J, He Y, Dai Y, Chen Y, Qiu J: [Greater auricular nerve graft for repair of facial nerve defects]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Apr;24(7):293-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Greater auricular nerve graft for repair of facial nerve defects].
  • OBJECTIVE: To retrospectively analysis the clinical data of facial nerve defects repair with greater auricular nerve graft.
  • In 3 patients of facial nerve tumors, the tumors involved multiple nerve segments, and histologic results were all schwannomas, preoperatively, 1 case had Grade III function, 2 cases had Grade V function.
  • In 2 patients of iatrogenic trauma of the facial nerve, the primary disease was chronic otitis media with cholesteatoma, the lesions were localized at the mastoid segment and the second genu respectively.
  • In addition to 3 cases lost to follow-up, the remaining patients, 4 recovered to a Grade III, 3 to a Grade VI, 2 to a Grade V and 2 remained at Grade VI.
  • Facial nerve reconstruction by means of greater auricular nerve grafting was a practical and effective method, the best postoperative recovery of facial nerve function was Grade III.
  • [MeSH-minor] Adult. Ear / innervation. Female. Humans. Male. Mastoid / surgery. Middle Aged. Nerve Regeneration. Retrospective Studies. Temporal Bone / injuries. Temporal Bone / surgery. Young Adult

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  • (PMID = 20545110.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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23. Ryan WR, Fee WE: Long-term great auricular nerve morbidity after sacrifice during parotidectomy. Laryngoscope; 2009 Jun;119(6):1140-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term great auricular nerve morbidity after sacrifice during parotidectomy.
  • OBJECTIVES/HYPOTHESIS: To clarify the extent and patient perspectives of great auricular nerve (GAN) morbidity and recovery after nerve sacrifice during parotidectomy 4 to 5 years after surgery.
  • RESULTS: Nineteen (86%) of 22 patients completed follow-up.
  • CONCLUSIONS: The posterior branch of the GAN should be preserved if it does not compromise tumor resection.
  • [MeSH-major] Cranial Nerves / surgery. Ear, External / innervation. Hypesthesia / etiology. Nerve Regeneration. Paresthesia / etiology. Parotid Diseases / surgery. Parotid Gland / surgery. Parotid Neoplasms / surgery. Postoperative Complications / etiology

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  • (PMID = 19399835.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Wirth GA, Sundine MJ, Kong AP, Carpenter PM: Auricular angioleiomyoma: a case report and review of the literature. Ear Nose Throat J; 2007 May;86(5):281-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auricular angioleiomyoma: a case report and review of the literature.
  • A 29-year-old woman presented with an unusual lesion on the right auricular antihelix.
  • The mass was resected, and a staged reconstruction was performed.
  • Most cases of angioleiomyoma involve the extremities; few have been described in the head and neck region, and very few of those have been reported on the ear.
  • Among those auricular angioleiomyomas that have been reported, most were distinctly painless.
  • We report a new, atypical case of this unusual tumor.
  • [MeSH-major] Angiomyoma / pathology. Ear Neoplasms / pathology. Ear, External / pathology

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  • (PMID = 17580807.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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25. Korotkikh NG, Ol'shanskiĭ MS, Shcherbinin AS, Stepanov IV, Alekseeva TV, Ovsiannikov IuM: [Endovascular microembolization of the posterior auricular artery in comprehensive surgical management of capillary angioma of the floor of the auricle]. Angiol Sosud Khir; 2007;13(4):74-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endovascular microembolization of the posterior auricular artery in comprehensive surgical management of capillary angioma of the floor of the auricle].
  • The article deals with the description of a rare clinical case wherein a 44-year-old female patient presenting with bleeding capillary angioma of the left auricle obstructing the auditory passage was fist subjected to endovascular microembolization of the posterior auricular artery by means of polyvinyl alcohol (PVA-500), followed by a second stage of virtually bloodlessly surgical removal of the tumour carried out five days thereafter.
  • Preoperative microembolization of a bleeding haemangioma arrests haemorrhage from the tumour, resulting in the decreased size thereof, as well as leading to circumscribing the tumour from healthy tissue.
  • Attention is paid to the fact that embolization of the auricular artery should be performed only after a thorough angiographic evaluation of the pattern of the blood flow in the tumour and adjacent vessels by means of the technique of selective catheterization and using only the officinal emboli.
  • [MeSH-major] Ear Neoplasms / therapy. Ear, External / blood supply. Embolization, Therapeutic / methods. Hemangioma, Capillary / therapy

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  • (PMID = 18385652.001).
  • [ISSN] 1027-6661
  • [Journal-full-title] Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery
  • [ISO-abbreviation] Angiol Sosud Khir
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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26. Roh JL: Resection of cervical vagal schwannoma via a post-auricular approach. Acta Otolaryngol; 2006 Mar;126(3):318-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection of cervical vagal schwannoma via a post-auricular approach.
  • However, because the conventional cervical approach leaves an incision scar in a visible area, other approaches need to be developed for young women who want the postoperative scar to be invisible.
  • A 28-year-old female underwent complete resection of a 4x4 cm tumor in her right upper neck via a post-auricular approach using an inverted V-shaped incision along the post-auricular sulcus and hairline.
  • The tumor was a schwannoma originating from the right cervical vagus nerve.
  • A cervical vagal schwannoma can be successfully removed by making an incision in a potentially invisible area.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neck / surgery. Neurilemmoma / surgery. Neurosurgical Procedures / methods. Vagus Nerve Diseases / surgery

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  • (PMID = 16618662.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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27. Adriane K, Huang J, Ding G, Chen J, Liu Y: Self assembled magnetic PVP/PVA hydrogel microspheres; magnetic drug targeting of VX2 auricular tumours using pingyangmycin. J Drug Target; 2006 May;14(4):243-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Self assembled magnetic PVP/PVA hydrogel microspheres; magnetic drug targeting of VX2 auricular tumours using pingyangmycin.
  • With advances in material science, magnetic drug targeting has emerged as one of the viable ways of attaining this.
  • In this study, we used self assembled PVP/PVA magnetic hydrogel microspheres to deliver pingyangmycin (Bleomycin A5) to rabbit auricular VX2 tumours in the presence of a 0.5 T permanent magnet both during and 24 h after perfusion.
  • A total of 22 New Zealand white rabbits ranging from 13 to 16 weeks and weighing 2.5-3.0 kg (2.46 +/- 0.2) successfully implanted with tumours 200-300 mm2 in size were used.
  • However, when compared to the group with 1 mg pingyangmycin(BLM) in 50 mg of ferrofluid and 0.5 mg (BLM) in 50 mg ferrofluid both with a permanent magnet in place for 24 h, the statistically significant difference was in favor of combined treatment, i.e. ferrofluid carrying drug in presence of a permanent magnet (p = 0.01).
  • The microspheres in conjunction with the magnet did deliver pingyangmycin to the tumour and hence may be of use in future as far as magnetic drug targeting is concerned.
  • However, more studies are still required to establish biodistribution and biostability not to forget drug release of ferrofluid of different chemotherapeutic agents available.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Bleomycin / analogs & derivatives. Drug Delivery Systems. Ear Neoplasms / drug therapy. Hydrogel / administration & dosage. Magnetics. Microspheres
  • [MeSH-minor] Animals. Drug Carriers. Polyvinyl Alcohol. Povidone. Rabbits

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  • (PMID = 16777683.001).
  • [ISSN] 1061-186X
  • [Journal-full-title] Journal of drug targeting
  • [ISO-abbreviation] J Drug Target
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Carriers; 11056-06-7 / Bleomycin; 11116-32-8 / bleomycetin; 25852-47-5 / Hydrogel; 9002-89-5 / Polyvinyl Alcohol; 9003-39-8 / Povidone
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28. Fujiwara T, Maeda M, Kuwae K, Nakagawa T, Nakao K: Free-prefabricated auricular composite graft: a new method for reconstruction following extended hemilaryngectomy. Br J Plast Surg; 2005 Mar;58(2):153-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Free-prefabricated auricular composite graft: a new method for reconstruction following extended hemilaryngectomy.
  • A free-prefabricated auricular composite graft was applied in two patients who underwent extended hemilaryngectomy.
  • [MeSH-major] Artificial Organs. Ear, External / surgery. Laryngeal Neoplasms / surgery. Laryngectomy / methods. Neck Dissection / methods. Surgical Flaps. Thyroid Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Microsurgery / methods. Neoplasm Recurrence, Local / surgery

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  • (PMID = 15710107.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Asawa Y, Ogasawara T, Takahashi T, Yamaoka H, Nishizawa S, Matsudaira K, Mori Y, Takato T, Hoshi K: Aptitude of auricular and nasoseptal chondrocytes cultured under a monolayer or three-dimensional condition for cartilage tissue engineering. Tissue Eng Part A; 2009 May;15(5):1109-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aptitude of auricular and nasoseptal chondrocytes cultured under a monolayer or three-dimensional condition for cartilage tissue engineering.
  • To elucidate the characterizations of chondrocytes originating from auricular cartilage (donors: 10-15 years) and nasoseptal one (20-23 years), we evaluated proliferation or matrix synthesis of both cells cultured under monolayer and collagen type I (COL1) three-dimensional (3D) conditions.
  • Three passages were needed until cell numbers of auricular chondrocytes in the 3D culture increased 1000-fold, although those in monolayer culture or nasoseptal monolayer and 3D cells reached a 1000-fold increase at four passages.
  • The downsizing of pellets may result from the upregulation of tumor necrosis factor (TNF)-alpha or the related proteinases, including matrix metalloproteinases (MMPs)-1, -2, and -3, and cathepsin B, suggesting that the nasoseptal chondrocytes, which are physiologically separated from COL1, may be hardly adapted for the COL1 3D proliferation condition.
  • However, according to our data using closely matched ones, the auricular chondrocytes seemed to more rapidly proliferate and produce less proteinases during this 3D culture than the nasoseptal ones.
  • [MeSH-major] Chondrocytes / cytology. Ear Cartilage / cytology. Nasal Cartilages / cytology. Tissue Engineering / methods
  • [MeSH-minor] Base Sequence. Cathepsin B / metabolism. Cell Culture Techniques / methods. Cell Proliferation. Cells, Cultured. Collagen Type I / genetics. Collagen Type I / metabolism. Collagen Type II / genetics. Collagen Type II / metabolism. Cytokines / metabolism. DNA Primers / genetics. Glycosaminoglycans / metabolism. Humans. Matrix Metalloproteinases / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Time Factors. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 19061429.001).
  • [ISSN] 1937-3341
  • [Journal-full-title] Tissue engineering. Part A
  • [ISO-abbreviation] Tissue Eng Part A
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type II; 0 / Cytokines; 0 / DNA Primers; 0 / Glycosaminoglycans; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; EC 3.4.22.1 / CTSB protein, human; EC 3.4.22.1 / Cathepsin B; EC 3.4.24.- / Matrix Metalloproteinases
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30. Dessy LA, Figus A, Fioramonti P, Mazzocchi M, Scuderi N: Reconstruction of anterior auricular conchal defect after malignancy excision: revolving-door flap versus full-thickness skin graft. J Plast Reconstr Aesthet Surg; 2010 May;63(5):746-52
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  • [Title] Reconstruction of anterior auricular conchal defect after malignancy excision: revolving-door flap versus full-thickness skin graft.
  • Skin tumours of the anterior auricular concha are not uncommon.
  • Wider excision and immediate reconstruction are required to reduce the risks of recurrence of the disease, cartilage infection and external ear distortion.
  • Post-auricular island flaps, such as the revolving-door (RD) flap, and full-thickness skin grafts (FTSGs) are the most-performed procedures.
  • Between March 2003 and January 2007, 40 patients affected by T1 and T2 non-melanotic skin cancer and T1 melanoma of the anterior conchal surface of the external ear were included in a prospective study and randomly assigned to the RD reconstructed group or to the FTSG reconstructed group to investigate, compare and define advantages and disadvantages of both the techniques.
  • The RD group demonstrated excellent cosmetic outcome, ideal colour match, adequate structure of external ear, projection and shape.
  • RD flap should be considered as the first choice for reconstruction of anterior auricular conchal defects following wider excision of skin tumours.
  • [MeSH-major] Ear Auricle. Ear Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Skin Transplantation / methods. Subcutaneous Tissue / transplantation. Surgical Flaps
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Female. Follow-Up Studies. Humans. Male. Melanoma / pathology. Melanoma / surgery. Middle Aged. Neoplasm Staging. Prospective Studies. Treatment Outcome

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  • [Copyright] Copyright (c) 2009. Published by Elsevier Ltd.
  • (PMID = 19357009.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Netherlands
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31. Kobayashi K, Ishihara H, Murakami R, Kinoshita N, Tokunaga K: Total lower eyelid reconstruction with a prefabricated flap using auricular cartilage. J Craniomaxillofac Surg; 2008 Mar;36(2):59-65

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Total lower eyelid reconstruction with a prefabricated flap using auricular cartilage.
  • INTRODUCTION: Various methods have been reported for reconstructing the lower eyelid, but there is still the problem of creating a deep fornix and a supportive eyelid for housing an artificial eye.
  • CASE REPORT: A new prefabricated flap was developed using auricular cartilage and the lateral femoral circumflex vessels as vascular pedicles.
  • This was applied in a 64-year-old male patient with total lower eyelid loss following an extended maxillectomy for tumour.
  • CONCLUSION: The prefabricated flap described here showed more flexibility and a longer vascular pedicle, thus improving the applications for use in patients with limited recipient vessels yet without major sacrifice or deformity in the donor area.
  • [MeSH-major] Blepharoplasty / methods. Ear Cartilage / blood supply. Ear Cartilage / transplantation. Eyelids / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Carcinoma, Squamous Cell / surgery. Eye Enucleation. Eye, Artificial. Humans. Male. Maxillary Neoplasms / surgery. Middle Aged. Oral Surgical Procedures / adverse effects. Orbital Implants. Rectus Abdominis / transplantation

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  • (PMID = 18255303.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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32. Suen DT, Chow TL, Lam CY, Wong ES, Lam SH: Sensation recovery improved by great auricular nerve preservation in parotidectomy: a prospective double-blind study. ANZ J Surg; 2007 May;77(5):374-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sensation recovery improved by great auricular nerve preservation in parotidectomy: a prospective double-blind study.
  • BACKGROUND: The great auricular nerve (GAN) is frequently sacrificed during parotidectomy and causes sensory disturbance of the auricle.
  • METHODS: Patients undergoing superficial or total conservative parotidectomy for benign tumours were recruited consecutively from November 1998 to September 2001.
  • RESULTS: A total of 21 patients were recruited for the study.
  • There was no difference in sex distribution, type of operation and pathology of parotid tumour between the two groups.
  • CONCLUSION: Great auricular nerve preservation minimizes the postoperative sensory disturbance and should be considered whenever tumour clearance is not compromised.
  • [MeSH-major] Ear, External / innervation. Otorhinolaryngologic Surgical Procedures / methods. Parotid Gland / surgery
  • [MeSH-minor] Double-Blind Method. Female. Humans. Male. Pain. Parotid Neoplasms / surgery. Prospective Studies. Sensation / physiology. Touch / physiology

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  • (PMID = 17497980.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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33. Wallen KE, Hadar EJ, Perry V, Bouldin TW, Loehr J, Blatt J: Posterior fossa neoplasm and PHACES syndrome: a case report. J Pediatr Hematol Oncol; 2009 Mar;31(3):203-5
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  • [Title] Posterior fossa neoplasm and PHACES syndrome: a case report.
  • A 4-year-old girl with PHACES syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac anomalies/coarctation of the aorta, eye abnormalities, and sternal clefting/supraumbilical raphe) developed a cerebellar pilocytic astrocytoma 18 months after resolution of her neck, ear, and thoracic hemangiomas.
  • Because cutaneous hemangiomas may have involuted by the time a patient is diagnosed with a central nervous system neoplasm, it seems possible that in other such patients the association may have gone unrecognized.
  • [MeSH-major] Abnormalities, Multiple. Astrocytoma / etiology. Brain / abnormalities. Hemangioma / complications. Infratentorial Neoplasms / etiology
  • [MeSH-minor] Child, Preschool. Female. Heart Septal Defects, Ventricular / complications. Humans. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Syndrome

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  • (PMID = 19262249.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Chadha A, Grob M, Soldin M: Use of the earlobe in auricular reconstruction post tumour extirpation. J Plast Reconstr Aesthet Surg; 2009 Apr;62(4):539-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of the earlobe in auricular reconstruction post tumour extirpation.
  • Flap vascularity is satisfactory and although the overall size of the ear is reduced, this is accepted for a rejuvenated shape and minimal morbidity.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Ear Auricle / surgery. Ear Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery

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  • (PMID = 18061546.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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35. Acartürk TO, Yiğenoğlu B, Pekedis O: Excision and "transcutaneous" lift in patients with neurofibromatosis of the fronto-temporo-orbital and auricular regions. J Craniofac Surg; 2009 May;20(3):771-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Excision and "transcutaneous" lift in patients with neurofibromatosis of the fronto-temporo-orbital and auricular regions.
  • Neurofibromatosis (NF) type 1 (von Recklinghausen disease) involves the face in up to 4% of the cases.
  • Patients present with varying degrees of disfigurement according to the extent and location of the tumor.
  • Many surgeons prefer multiple serial excisions, as it is almost impossible to remove the entire tumor without major extirpative surgery.
  • However, because the "debulkings" are usually not accompanied by durable lift procedures, the skin sags again because of the gravitational effect on the remaining tumor.
  • In a series of 7 patients with NF of the frontal, temporal, facial, and cervical areas and the auricle, a lift procedure was performed after functional debulking of the tumor.
  • The lift sutures, which passed transcutaneously, supported and fixed the predetermined areas on the skin or the ear cartilage to the periosteum of the calvarium.
  • After 1 year, because of the presence of disease, there was a slow relapse in the amount of sagging in the temporal and frontal areas, but not in the auricle.
  • In 3 patients, re-excision of the disease and repeat lift procedure using the same technique were performed after 1 year.
  • All were satisfied with the results and stated that the period without sagging lasted longer compared with their prior surgeries.
  • The patients with NF type 1 undergo many operations during their lifetime.
  • These procedures are not aimed to completely eliminate the disease, but rather to improve function and appearance.
  • When these debulking procedures are combined with durable lifting procedures, the results are longer lasting with improved quality of life.
  • [MeSH-major] Facial Neoplasms / surgery. Neurofibromatosis 1 / surgery. Reconstructive Surgical Procedures / methods. Skin Neoplasms / surgery. Suture Techniques
  • [MeSH-minor] Adolescent. Adult. Ear, External / surgery. Esthetics. Feedback. Female. Follow-Up Studies. Forehead / surgery. Head and Neck Neoplasms / surgery. Humans. Male. Neoplasm Recurrence, Local / surgery. Orbit / surgery. Patient Care Planning. Patient Participation. Patient Satisfaction. Quality of Life. Reoperation. Retrospective Studies. Temporal Bone / surgery. Young Adult

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  • (PMID = 19480038.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Clark RR, Shaw-Dunn J, Soutar DS: A cadaveric study of auricular lymphatics and implications for sentinel lymph node biopsy. Clin Anat; 2010 Oct;23(7):792-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A cadaveric study of auricular lymphatics and implications for sentinel lymph node biopsy.
  • Malignant cutaneous tumors of the auricle are known to have a high rate of spread to the regional lymph nodes, and, for this reason, removal of the lymph nodes, for diagnostic or therapeutic purposes, is often required.
  • Recent experience with sentinel node biopsy in cutaneous tumors of the head and neck has questioned the traditional lymphatic pathways and prompted a new study.
  • Lymphatic pathways from the auricle were demonstrated by India ink injection of five auricles in three cadavers followed by block dissection and Spalteholz clearing of en bloc specimens.
  • There are five different locations for sentinel nodes: superficial parotid, anterior mastoid, infra-auricular parotid, deep to sternocleidomastoid, and lateral mastoid.
  • Lymphatics from the ear lie close to the mastoid bone and pass deep to the insertion of sternocleidomastoid where they may be difficult to follow.
  • Sentinel lymph node biopsy for cutaneous tumors of the auricle is possible, but the presence of skip metastases should be considered.
  • [MeSH-major] Ear Auricle / anatomy & histology. Lymphatic System / anatomy & histology
  • [MeSH-minor] Aged, 80 and over. Female. Head and Neck Neoplasms / pathology. Humans. Lymphatic Metastasis. Male. Sentinel Lymph Node Biopsy

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20641070.001).
  • [ISSN] 1098-2353
  • [Journal-full-title] Clinical anatomy (New York, N.Y.)
  • [ISO-abbreviation] Clin Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; auricle / external ear / lymphatic metastases / melanoma / neck dissection / sentinel lymph node biopsy / squamous cell carcinoma
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37. Patrizi A, Tabanelli M, Filippi G, Gurioli C, Nozza P, Savoia F, Dalmonte P, Misciali C: An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. Dermatol Online J; 2010;16(5):4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy.
  • A 13-year-old boy presented to us for the evaluation of a slowly growing mass over the left preauricular region.
  • The findings of magnetic resonance imaging (MRI) and vascular MRI led us to suspect a vascular growth.
  • Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of the soft tissue with fibrohistiocytic and vascular differentiation that shows an intermediate malignancy grade, mainly occurs in patients younger than 20 years of age, and is usually localized on the extremities.
  • Angiomatoid fibrous histiocytoma is considered to be a tumor of intermediate malignancy because of its less aggressive course in contrast to conventional malignant fibrous histiocytoma (MFH).
  • Our case of AFH is peculiar because of its localization in the pre auricular region and because it appeared in a young patient.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Ear, External. Humans. Male

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  • (PMID = 20492821.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Dib LL, de Oliveira JA, Neves RI, Sandoval RL, Nannmark U: Auricular rehabilitation by means of bone grafting from the iliac crest in combination with porous extraoral implants: a case report. Clin Implant Dent Relat Res; 2007 Dec;9(4):228-32
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  • [Title] Auricular rehabilitation by means of bone grafting from the iliac crest in combination with porous extraoral implants: a case report.
  • The use of extraoral fixtures as bone anchorage was introduced many years ago and since then many patients were rehabilitated with better results.
  • MATERIALS AND METHODS: A new porous surfaced Brazilian extraoral implant (MasterExtra, Conexão, Sistema de Próteses, São Paulo, Brazil) was used.
  • RESULTS: Eight months after grafting, four fixtures were inserted.
  • Three fixtures were used for connection of an auricular epithesis.
  • [MeSH-major] Carcinoma, Basal Cell / rehabilitation. Ear, External / surgery. Head and Neck Neoplasms / rehabilitation. Prostheses and Implants. Prosthesis Implantation
  • [MeSH-minor] Adult. Bone Transplantation. Female. Humans. Neoplasm Recurrence, Local. Porosity. Skin Transplantation. Vibration

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  • (PMID = 18031445.001).
  • [ISSN] 1523-0899
  • [Journal-full-title] Clinical implant dentistry and related research
  • [ISO-abbreviation] Clin Implant Dent Relat Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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39. Clark RR, Soutar DS: Lymph node metastases from auricular squamous cell carcinoma. A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg; 2008 Oct;61(10):1140-7
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  • [Title] Lymph node metastases from auricular squamous cell carcinoma. A systematic review and meta-analysis.
  • INTRODUCTION: Squamous cell carcinoma arising on the auricle is believed to metastasise to the regional lymph nodes more frequently than comparable tumours at other sites.
  • Metastatic spread of these tumours is associated with a poor outcome but there is no clear consensus of opinion on how to identify patients at risk of metastatic spread and treat them.
  • RESULTS: The metastatic rate is 11.2% with spread to the parotid and upper deep cervical chain most common.
  • Depth of invasion, tumour size, degree of cellular differentiation and incomplete primary excision margins may be useful in identifying lesions most at risk of metastasising but there is insufficient evidence at present to allow targeted neck dissections.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Ear Auricle. Ear Neoplasms / epidemiology

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  • (PMID = 18675609.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 62
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40. Seidler AM, Bramlette TB, Washington CV, Szeto H, Chen SC: Mohs versus traditional surgical excision for facial and auricular nonmelanoma skin cancer: an analysis of cost-effectiveness. Dermatol Surg; 2009 Nov;35(11):1776-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs versus traditional surgical excision for facial and auricular nonmelanoma skin cancer: an analysis of cost-effectiveness.
  • PARTICIPANTS: Input data were derived from results of a consecutive sample of 98 patients with nonmelanoma skin cancer on the face and ears, estimates in the literature on 5-year recurrence rates, and a query of healthy focus-group participants.
  • RESULTS: The Mohs strategy was $292 less expensive than the traditional surgical strategy and was more effective by an incremental quality-adjusted life year of 0.056 (translating to approximately 3 weeks of optimal quality of life).
  • Results were robust to subgroup and sensitivity analyses.
  • [MeSH-major] Ear Neoplasms / economics. Ear Neoplasms / surgery. Facial Neoplasms / economics. Facial Neoplasms / surgery. Mohs Surgery / economics. Skin Neoplasms / economics. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Cost-Benefit Analysis. Female. Humans. Male. Monte Carlo Method. Neoplasm Recurrence, Local. Quality-Adjusted Life Years

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  • (PMID = 19737291.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / K23AR02185-01A1; United States / NIAMS NIH HHS / AR / P30AR42687; United States / NIAMS NIH HHS / AR / T32 AR07587
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Ciocca L, Mingucci R, Bacci G, Scotti R: CAD-CAM construction of an auricular template for craniofacial implant positioning: a novel approach to diagnosis. Eur J Radiol; 2009 Aug;71(2):253-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CAD-CAM construction of an auricular template for craniofacial implant positioning: a novel approach to diagnosis.
  • A novel approach to the diagnosis of bone available for craniofacial implant positioning is discussed in a case that required ear ablation for tumor removal.
  • A mirrored volume of the healthy ear was rapidly prototyped for a clinical trial in an appropriate position relative to the patient's face.
  • Three ideal positions for the implant were chosen in the inner of the volume of the mirrored ear.
  • [MeSH-major] Computer-Aided Design. Ear, External / abnormalities. Ear, External / surgery. Prostheses and Implants. Prosthesis Fitting / methods. Surgery, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 18562144.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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42. Clark RR, Soutar DS, Hunter KD: A retrospective analysis of histological prognostic factors for the development of lymph node metastases from auricular squamous cell carcinoma. Histopathology; 2010 Jul;57(1):138-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A retrospective analysis of histological prognostic factors for the development of lymph node metastases from auricular squamous cell carcinoma.
  • Identification of patients with a high risk of lymph node metastases would allow prophylactic treatment to the draining lymph nodes, but there are no established clinical or histopathological criteria to predict which tumours have a high risk of metastasis.
  • METHODS AND RESULTS: The study was a retrospective analysis of the clinical and histological features of 229 cases of SCC of the auricle, with a minimum of 2 years' clinical follow-up.
  • Of the patients with metastatic disease 66.7% died, despite multi-modality treatment.
  • Tumours with a depth of invasion >8 mm or a depth of invasion between 2 and 8 mm in conjunction with evidence of destructive cartilage invasion, lymphovascular invasion or a non-cohesive invasive front had a high risk of metastasis (56% and 24%, respectively).
  • CONCLUSIONS: Patients with high-risk tumours, as assessed histopathologically, should be considered for prophylactic therapy to or staging of the regional lymph nodes.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Ear Neoplasms. Lymphatic Metastasis
  • [MeSH-minor] Aged. Aged, 80 and over. Ear Cartilage / pathology. Female. Humans. Lymphatic Vessels / pathology. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Prognosis. Retrospective Studies. Risk Factors. Scotland / epidemiology

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  • (PMID = 20653785.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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43. Tysome JR, Harcourt J, Patel MC, Sandison A, Michaels L: Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm? Ear Nose Throat J; 2008 Jul;87(7):378-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm?
  • Aggressive papillary tumors of the middle ear are rare, and their true origin is not clear.
  • We describe the clinical, radiologic, genetic, and histopathologic features of a papillary epithelial tumor filling the middle ear of a 68-year-old woman.
  • A literature search revealed 24 previously reported cases of such a papillary epithelial tumor of the middle ear.
  • All except 2 cases demonstrated apical petrous temporal bone invasion on imaging, and it has been suggested that they arose from a primary endolymphatic sac tumor, which has a similar papillary epithelial histology.
  • Substantial numbers of cases of papillary epithelial tumors involving the middle ear are reported to be associated with von Hippel-Lindau disease, as are known cases of endolymphatic sac tumor.
  • This is the third reported case of papillary epithelial tumor of the middle ear that does not show apical petrous temporal bone invasion on imaging, suggesting that such neoplasms do not always arise from a primary in the endolymphatic sac.
  • [MeSH-major] Cystadenoma, Papillary / diagnosis. Ear Neoplasms / diagnosis. Ear, Middle / pathology. Endolymphatic Sac

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  • (PMID = 18633929.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Rinaldo A, Devaney KO, Ferlito A: Merkel cell carcinoma of the auricle. Acta Otolaryngol; 2005 Feb;125(2):125-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Merkel cell carcinoma (MCC) is an uncommon cutaneous neoplasm which arises in adults with a peak incidence in the sixth and seventh decades.
  • Among head and neck primary sites, auricular MCC has proven to be rare and only 20 cases have been reported in the literature.
  • Auricular MCC follows the same aggressive course as has been documented for MCC arising elsewhere: the tumor has a propensity for recurring locally and metastasizing to regional lymph nodes and distant sites.
  • Location of MCC in the auricular regions does not appear to confer any survival advantage compared with MCC arising elsewhere.
  • What role regional node dissection, radiation therapy and chemotherapy may play in the standard treatment of auricular MCC remains to be clearly established.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Ear, External. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / radiotherapy. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged

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  • (PMID = 15880940.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 34
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45. Bień S, Kamiński B, Kopczyński J, Sygut J: [The synchroneous tumors of different histopathology in the parotid salivary gland]. Otolaryngol Pol; 2006;60(5):703-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The synchroneous tumors of different histopathology in the parotid salivary gland].
  • Ipsilateral salivary gland tumors of different histological types are very rare.
  • 2005), in 6 (3.06%) cases synchronous tumors of different type has been found in pathologic specimens.
  • In 5 cases pleomorphic adenoma was one of synchronous tumor--in 2 cases with adenocarcinoma and in single cases with salivary duct carcinoma, adenolymphoma, and myoepithelioma.
  • In one case, the adenolymphoma was synchronous with carcinoma planoepitheliale metastaticum from the primary in the skin post auricular area (late metastasis).
  • Following the review of literature concerning the problem, two concepts has been critically discussed--the real synchronous occurrence of two different tumors, and transformation of benign tumor of salivary neoplasm to its malignant form.
  • [MeSH-major] Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Adult. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 17263242.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 24
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46. Scierski W, Polok A, Namysłowski G, Błazewicz M, Pamuła E, Stodolak E, Nozyński J, Zwirska-Korczala K, Szwarc K, Misiołek M, Czecior E, Turecka L, Lisowska G, Orecka B: [Study of selected biomaterials for reconstruction of septal nasal perforation]. Otolaryngol Pol; 2007;61(5):842-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The reasons of septal nasal perforations are injuries, neoplasm, self-mutilation, chronic rhinitis, allergy, Wegener granuloma, sarcoidosis, tuberculosis, toxic metals (arsenic, chrome), some drugs (steroids), narcotizing agents (cocaine) and complications after endoscopic and septal nasal operations.
  • The biomaterials were implanted in the rabbit auricular cartilage because of its similarity to the septum and easy surgical access.
  • RESULTS: A very good integration of PGLA implant with auricular cartilage was observed.
  • CONCLUSIONS: 4 months after implantation of PGLA in the rabbit auricular cartilage very good macroscopic and histological results were achieved.

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  • (PMID = 18552032.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biocompatible Materials; 25104-18-1 / Polylysine; 25513-46-6 / Polyglutamic Acid; 27456-64-0 / poly(glutamic acid-lysine); 9002-84-0 / Polytetrafluoroethylene
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47. Gierek T, Majzel K, Zbrowska-Bielska D, Gołab L, Jezierska M: [Treatment results in external and middle ear malignant neoplasms of patients treated at the Laryngology Department of Medical University of Silesia between 1991-2001]. Otolaryngol Pol; 2005;59(2):183-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment results in external and middle ear malignant neoplasms of patients treated at the Laryngology Department of Medical University of Silesia between 1991-2001].
  • The authors present 18 patients with malignant neoplasms of the ear and temporal bone who were treated in the Clinic of Laryngology Medical University of Silesia in Katowice in the years 1991-2001.
  • The neoplasm was located on the auricle in 7 patients (39%), in the external auditory canal in 4 (22%) patients, in the middle ear in 5 patients (28%) and in 2 cases (11%) it was difficult to establish primary site.
  • The best outcomes were in auricular neoplasms.
  • The treatment results were much worse in neoplasms of the external auditory canal and the middle ear.
  • Over 3 year follow-up in 10 patients (55%) with ear and temporal bone neoplasms shows no recurrence.
  • [MeSH-major] Ear Neoplasms / therapy. Ear, External. Ear, Middle. Skull Neoplasms / therapy. Temporal Bone
  • [MeSH-minor] Adult. Aged. Carcinoma, Squamous Cell / therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 16095085.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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48. Layadi F, Aniba K, Lmejjati M, Aït Elqadi A, Aït Benali S: [Giant osteoid osteoma of the posterior skull base. A case report and literature review]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):128-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Ostéome ostéoïde géant de l'étage postérieur de la base du crâne. A propos d'un cas et revue de la littérature.
  • BACKGROUND: Osteoid osteoma is a benign bone neoplasm which is seen in the long bones.
  • OBSERVATION: We report a rare case of a large osteoid osteoma of the petro-occipital area in a 26-year-old man.
  • He presented with clinical sign of raised intracranial pressure, cerebellar symptoms and large left retro-auricular swelling.
  • CONCLUSION: Although benign and rare, osteoid osteoma can present with neurological deficit due to mass effect and involvement of nervous structures especially in the posterior skull base.
  • [MeSH-major] Osteoma / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 16840973.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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49. Devaney KO, Boschman CR, Willard SC, Ferlito A, Rinaldo A: Tumours of the external ear and temporal bone. Lancet Oncol; 2005 Jun;6(6):411-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumours of the external ear and temporal bone.
  • Symptoms such as hearing impairment, tinnitus, or a disturbance in sense of balance can generally be attributed to non-neoplastic causes, such as otitis media, otosclerosis, or trauma.
  • Less commonly, auricular signs and symptoms are the result of non-neoplastic and neoplastic space-occupying lesions.
  • The external ear can be the site of development of squamous carcinomas and basal-cell carcinomas; the middle ear and inner ear can host metastatic deposits, and primary squamous carcinomas and adenocarcinomas.
  • Most auricular malignant diseases occur in adulthood; only the rhabdomyosarcomas of the middle ear arise in children.
  • Most malignant diseases of the auricular apparatus are treated by a combination of surgery (commonly including radical excision of temporal bone), radiotherapy, and chemotherapy.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear Neoplasms / therapy. Ear, External. Skull Neoplasms / diagnosis. Skull Neoplasms / therapy. Temporal Bone

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  • (PMID = 15925819.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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50. Viswanatha B: Kimura's disease in children: a 9 years prospective study. Int J Pediatr Otorhinolaryngol; 2007 Oct;71(10):1521-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kimura's disease in children: a 9 years prospective study.
  • Kimura's disease is a rare form of chronic inflammatory disorder involving subcutaneous tissue, predominantly in the head and neck region and frequently associated with lymphadenopathy and/or salivary gland enlargement.
  • The nodular lesions are deep seated in subcutaneous tissue and clinically may mimic a neoplasm.
  • Hence head and neck surgeons need to be aware of clinical presentation of Kimura's disease.
  • OBJECTIVES: To study the clinical presentations, management and complications of Kimura's disease in pediatric age group.
  • RESULTS: All the patients presented with painless swelling in the head and neck region.
  • Post-auricular region was the commonest site (50%).
  • One patient had nephrotic syndrome (5.5%).
  • CONCLUSION: Post-auricular region is the commonest site of involvement.
  • The only systemic complication is nephrotic syndrome.

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  • (PMID = 17586058.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 37341-29-0 / Immunoglobulin E
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51. Shetty C, Avinash KR, Auluck A: Schwannoma of vagus nerve masquerading as a parotid tumour. Dentomaxillofac Radiol; 2006 Sep;35(5):376-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannoma of vagus nerve masquerading as a parotid tumour.
  • A post-auricular swelling is the most common presentation of a parotid tumour, the majority of which are benign neoplasms like pleomorphic adenoma.
  • This case report discusses a post-styloid parapharyngeal space tumour presenting as a post-auricular mass which, on initial clinical and cytological examination, was diagnosed as pleomorphic adenoma.
  • [MeSH-major] Cranial Nerve Neoplasms / radiography. Neurilemmoma / radiography. Vagus Nerve Diseases / radiography
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Parotid Neoplasms / diagnosis. Pharynx / radiography. Tomography, Spiral Computed

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  • (PMID = 16940487.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Wang LL, Gao QH, Zheng GJ, Wang XY, Zhou L, Wang CM, Wen YM: [Embolization and degradation of arteries in vivo by pingyangmycin albumin microspheres]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2009 Mar;40(2):279-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PYM hydrochloride + 0.9% NaCl, PYM + soybean oil, and PYM-AMS + soybean oil were injected into the central auricular arteries of the rabbits in the three experimental groups, respectively, for about 30 seconds (0.26 mL/per ear, which contained PYM 5 mg/mL).
  • RESULTS: The PYM + 0.9% NaCl group had no significant vessel changes.
  • At the 21st day, mild proliferation of endothelial cells and walls of central auricular arteries were observed, especially on the intima.
  • In the PYM-AMS group, the central auricular arteries were narrowed at the 7th day after injection.
  • At the 14th day, significant proliferation of endothelial cells and walls of central auricular arteries were observed.
  • At the 21st day, the walls of central auricular arteries and some small veins proliferated obviously, and the arteries were sclerostenosed.
  • CONCLUSION: PYM-AMS may become an option for the treatment of large venous or arteriovenous malformations and for the local chemotherapy of malignant tumors.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Bleomycin / analogs & derivatives. Chemoembolization, Therapeutic / methods. Endothelial Cells / drug effects. Serum Albumin, Bovine

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  • (PMID = 19462907.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Serum Albumin, Bovine; 11056-06-7 / Bleomycin; 11116-32-8 / bleomycetin
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53. Wang RC, Barber AE, Ditmyer M, Vantine P: Distal facial nerve exposure: a key to partial parotidectomy. Otolaryngol Head Neck Surg; 2009 Jun;140(6):875-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2) Be able to incorporate other modifications of parotidectomy including preservation of the great auricular nerve, superficial musculo-aponeurotic system (SMAS), and parotid duct.
  • STUDY DESIGN: Case series with chart review of partial parotidectomy for benign neoplasms and intraparotid lymph nodes, using antegrade (Group 1) or distal (Group 2) facial nerve exposure, and those conserving the great auricular nerve, SMAS, and parotid duct (Group 3).
  • The great auricular nerve, parotid duct, and SMAS were preserved when possible.
  • RESULTS: No difference in facial nerve function was found between the groups.
  • Group 3 had better ear lobule cutaneous sensation.
  • CONCLUSIONS: Partial parotidectomy utilizing distal facial nerve exposure can reduce the extent of surgical dissection, facilitate preservation of the parotid duct and great auricular nerve, and allow greater flexibility in the choice of skin and SMAS incisions.
  • [MeSH-major] Facial Nerve / anatomy & histology. Facial Nerve / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19467407.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Schrom T, Horenburg L, Holz S, Paschen C: [Evaluation of quality of life following prosthetic replacement of the auricle]. HNO; 2010 Feb;58(2):134-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Of 18 patients (14 male, 4 female), 10 had lost an auricle due to a neoplasm, 2 traumatically, while 6 patients showed a congenital lack of an auricle.
  • RESULTS: Analysis of the data of all patients with prostheses in comparison with the age-based general population showed a lower score value for quality of life, indicating a poorer quality of life.
  • Patients with neoplasms achieved higher values compared with the age-based standard value; in contrast, the other patients showed lower values in nearly every respect.
  • The gender-related analysis of the results showed a poorer quality of life for females than for males.
  • The overall acceptance of auricular prostheses can be considered good, especially among patients suffering from neoplasms.
  • In order to be able to evaluate the results and compare the different working groups more sufficiently it would be desirable to use standardized test procedures and a larger patient collective.
  • [MeSH-major] Ear, External. Prostheses and Implants / psychology. Quality of Life / psychology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ear Neoplasms / psychology. Ear Neoplasms / surgery. Equipment Failure Analysis. Female. Germany. Humans. Male. Middle Aged. Patient Satisfaction. Postoperative Complications / psychology. Prosthesis Design. Prosthesis Fitting. Surveys and Questionnaires. Young Adult

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  • [CommentIn] HNO. 2010 Feb;58(2):132-3 [20127063.001]
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  • (PMID = 19727623.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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55. Mondin V, Rinaldo A, Shaha A, Cureoglu S, Devaney KO, Suárez C, Ferlito A: Malignant melanoma of the auricle. Acta Otolaryngol; 2005 Nov;125(11):1140-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant melanoma of the auricle.
  • Malignant melanomas are found in a variety of locations, ranging from sun-exposed skin to the nasal cavity and paranasal sinuses.
  • Melanomas arising in the head and neck region comprise some 20% of all melanomas; of these, 7-15% occur in the vicinity of the external ear (most often on the helix).
  • Auricular melanomas, like those arising elsewhere, are rare in childhood and are most often first diagnosed in men in their 50s.
  • Melanomas of the external ear may present as flat pigmented lesions or as raised mass lesions; amelanotic (non-pigmented) variants exist as well.
  • Auricular melanomas are frequently recognized pathologically as either superficial spreading melanomas or nodular melanomas.
  • These tumors are aggressive, with a propensity for spreading to both regional lymph nodes and distant sites.
  • Key pathologic prognostic features of auricular melanomas include the histological subtype, tumor thickness, level of invasion and presence of ulceration.
  • This is a tumor which is often overlooked until late in its course, with tragic consequences; vigilance and aggressive attempts at identifying these tumors at earlier stages are strongly advocated.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear, External. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Neoplasm Staging. Prognosis. Sentinel Lymph Node Biopsy

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  • (PMID = 16353384.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 42
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56. Karsidag S, Ozcan A, Ozkaya O, Ugurlu K, Bas L: Use of wide bipedicled pericranial flap in anterior scalp reconstruction. J Craniofac Surg; 2009 Nov;20(6):2248-51
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The multiple blood supply of the pericranial tissue enables this versatility, with a rich, anastomosing arterial supply from the supraorbital, supratrochlear, superficial temporal, posterior auricular, and occipital vessels.
  • After tumor excision was completed, a pericranial flap was planned on the caudal side of the defect.
  • A bipedicle-based pericranial flap was outlined with the use of a sharp dissection; this flap was elevated in a submusculoaponeurotic plane.
  • The bipedicled pericranial flap, whose arterial supply was from the superficial and posterior auricular arteries, was transposed to the frontal defect.We preferred a bipedicled flap, whose arterial supply is from the superficial temporal and posterior auricular arteries to augment vascular supply.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Scalp / surgery. Skin Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Ear, External / blood supply. Fascia / transplantation. Humans. Male. Middle Aged. Periosteum / transplantation. Skin Transplantation

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  • (PMID = 19934684.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Witt RL: Minimally invasive surgery for parotid pleomorphic adenoma. Ear Nose Throat J; 2005 May;84(5):308, 310-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Compared with total parotidectomy and complete superficial parotidectomy for the removal of a parotid pleomorphic adenoma, partial superficial parotidectomy with dissection and preservation of the facial nerve--defined as the excision of a tumor with a 2-cm margin of normal parotid parenchyma except at the point where the tumor abuts the facial nerve--is associated with a lower incidence of transient facial nerve dysfunction, facial contour disfigurement, and subsequent Frey's syndrome.
  • The author hypothesized that the use of this procedure to remove a benign pleomorphic adenoma might result in even less morbidity (transient or permanent facial nerve dysfunction, facial contour disfigurement, Frey's syndrome, and hypoesthesia) without increasing the risk of recurrence if only a 1-cm margin of normal parotid parenchyma was removed and if the posterior branches of the great auricular nerve were preserved To test this hypothesis, the author conducted a retrospective study of 30 patients--15 who had undergone the standard partial procedure (2-cm margin with great auricular nerve sacrifice) and 15 who had undergone the modified version (1-cm margin with great auricular nerve preservation).
  • After a mean follow-up of 10 years, there were no significant differences between the two groups in terms of facial nerve dysfunction, facial contour disfigurement, Frey's syndrome, and recurrence.
  • Moreover, preservation of the posterior branches of the great auricular nerve did not prevent alterations in sensitivity (i.e., hypoesthesia) in 7 of the 15 patients (46.7%).
  • Although a 1-cm area of normal parotid parenchyma around a benign pleomorphic adenoma was a safe margin, it was no better than a 2-cm margin in terms ofmorbidity and recurrence.
  • Preservation of the posterior branches of the great auricular nerve will result in an objective reduction in hypoesthesia in approximately half of patients, but because it does not ensure freedom from sensitivity alterations in all cases, patients should be advised of the risk of postoperative numbness in the earlobe and the infraauricular area.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Parotid Neoplasms / surgery

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  • (PMID = 15971755.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Adhikary B, Sen I, Basu AJ, Bandyopadhyay SN, Saha D, Basu SK: Solitary neurilemmoma in postaural region. J Indian Med Assoc; 2007 May;105(5):268, 277

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurilemmoma in postaural region arising from great auricular nerve is an extremely rare tumour.
  • An 11 years boy presented with pain and swelling behind his left ear for last 3-4 years.
  • The tumour was completely removed by an incision through postaural route.
  • [MeSH-major] Ear Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 17915796.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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59. de Ru JA, van Benthem PP, Bleys RL, Hordijk GJ: Prevention of Frey syndrome in parotid gland surgery. J Otolaryngol; 2007 Oct;36(5):291-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevention of Frey syndrome in parotid gland surgery.
  • OBJECTIVE: This study discusses the anatomy and surgical techniques for the prevention of Frey syndrome.
  • We also tried to preserve part of the great auricular nerve (GAN).
  • METHODS: Patients operated on for parotid gland tumours in our hospitals during the last 3 years underwent starch-iodine testing after at least 1 year of follow-up.
  • MAIN OUTCOME MEASURES: The number of patients developing Frey syndrome.
  • We hypothetically explored the importance of preserving both the auriculotemporal and the great auricular nerve.
  • RESULTS: Eighty-one patients were operated on for a parotid gland tumour.
  • All four patients with Frey syndrome did not have a SMAS interposition.
  • CONCLUSION: We advocate our technique in primary benign tumours.
  • Further research to clarify the parasympathetic and sympathetic function of the great auricular nerve and the cutaneous branch of the auriculotemporal nerve is necessary.
  • [MeSH-major] Otorhinolaryngologic Surgical Procedures / methods. Parotid Neoplasms / surgery. Surgical Flaps. Sweating, Gustatory / prevention & control

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  • (PMID = 17963668.001).
  • [ISSN] 0707-7270
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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60. Wang C, Liu J, Gao Q, Bi Y, Gan L, Wang X, Hou S: Preparation and characterization of Pingyangmycin-loaded bovine serum albumin microspheres for embolization therapy. Int J Pharm; 2007 May 24;336(2):361-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The MSs showed a rather high entrapment efficiency (EE%) of 87.6+/-5.7% and the drug loading efficacy (DL%) was 20.2+/-1.3%.
  • The drug release behaviors were evaluated both in vitro and in vivo, using UV-spectroscopy and HPLC, respectively.
  • The in vitro results showed a significantly delayed release of drug for 10 days.
  • The central auricular artery of rabbit was chosen as an embolization sites to study the in vivo drug release and the pharmacokinetics of the MSs compared with PYM injections.
  • Experiments performed by artery perfusion and embolization in rabbits central auricular artery revealed that the PYM loaded BSA-MSs (PYM-BSA-MSs) could obviously prolong in vivo drug release, extend the mean residence time (MRT) and had equal bioavailability compared with plain PYM injections.
  • These results demonstrated that by embolization of the central auricular artery with PYM-BSA-MSs, the local drug concentration could maintain at a relative high level for a longer time, thus achieve the aim of tumor targeting therapy.
  • PYM-BSA-MSs are excellent potential alternatives of interventional embolization materials for the treatment of maxillofacial region tumors.
  • [MeSH-minor] Animals. Arteries. Biological Availability. Chromatography, High Pressure Liquid. Cross-Linking Reagents / chemistry. Delayed-Action Preparations / administration & dosage. Delayed-Action Preparations / pharmacokinetics. Drug Carriers / chemistry. Drug Delivery Systems. Formaldehyde / chemistry. Particle Size. Rabbits. Random Allocation. Serum Albumin, Bovine / chemistry. Spectrophotometry, Ultraviolet

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  • (PMID = 17360133.001).
  • [ISSN] 0378-5173
  • [Journal-full-title] International journal of pharmaceutics
  • [ISO-abbreviation] Int J Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cross-Linking Reagents; 0 / Delayed-Action Preparations; 0 / Drug Carriers; 0 / Serum Albumin, Bovine; 11056-06-7 / Bleomycin; 11116-32-8 / bleomycetin; 1HG84L3525 / Formaldehyde
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61. Cordova A, Pirrello R, D'Arpa S, Moschella F: Superior pedicle retroauricular island flap for ear and temporal region reconstruction: anatomic investigation and 52 cases series. Ann Plast Surg; 2008 Jun;60(6):652-7
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superior pedicle retroauricular island flap for ear and temporal region reconstruction: anatomic investigation and 52 cases series.
  • BACKGROUND: On the basis of a previously published anatomic study on the superior auricular artery (SAA) and on a series of 52 consecutive cases, the authors propose a new superior pedicle retroauricular island flap (SP-RIF) for defects of the upper half of the ear and for temporal region or superficial helical defects.
  • METHODS: Twenty five auricular regions were dissected after colored latex injection in the carotid artery of 13 fresh cadavers to investigate the SAA.
  • A SP-RIF was used in 52 consecutive cases after tumor excision.
  • In 51 cases, the defect involved the upper half of the ear.
  • RESULTS: The SAA originates either from the superficial temporal artery (44%) or from its parietal branch (56%).
  • Esthetic results of the reconstruction were excellent.
  • CONCLUSIONS: The SP-RIF can be considered as a first choice option to repair nonmarginal losses of substance of the upper half of the ear.
  • [MeSH-major] Ear, External / surgery. Face / anatomy & histology. Face / surgery. Reconstructive Surgical Procedures / methods. Skin Transplantation / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cadaver. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Ear Neoplasms / surgery. Esthetics. Humans. Middle Aged

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  • (PMID = 18520202.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Joshi RR, Nepal A, Ghimire A, Karki S: Eccrine poroma in neck of a child--a rare presentation. Nepal Med Coll J; 2009 Mar;11(1):73-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine poroma in neck of a child--a rare presentation.
  • An eccrine poroma is a common benign tumour arising from the eccrine sweat gland duct epithelium in the dermo-epidermal region.
  • Here we report a case of an eccrine poroma in the retro-auricular area just below and behind the lobule of the left pinna in a nine years old child.
  • [MeSH-major] Acrospiroma / diagnosis. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19769246.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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63. Zhang B, Huang HZ, Pan CB, Wang JG, Chen WL, Yang ZH: [Effect analysis of modified radical surgery in tongue cancer at early stages]. Zhonghua Yi Xue Za Zhi; 2007 Sep 25;87(36):2578-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Six patients with early stage squamous cell carcinoma of tongue underwent a procedure of modified radical surgery, in which an inconspicuous incision was used, the external jugular vein, sternocleidomastoid muscle, spino-accessory nerve, and greater auricular nerve were preserved, half of glosso and mouth floor were excised, and the defect was repaired instantly.
  • RESULTS: Compared with classic radical neck dissection, this procedure of modified radical surgery showed an inconspicuous incision and pretty appearance, minor edema on face and neck, better shoulder function, and sensation of auricular skin.
  • The patients showed better oncological safety, pretty appearance of tongue, and better oral function of speech, swallow and mastication.
  • CONCLUSION: This ideal procedure of modified radical surgery in tongue cancer at early stages lessens or avoids destruction of face and neck, shoulder malfunction, numbness of auricular skin, and oral dysfunction of speech, swallow and mastication without impairment on the oncologic safety of the radical surgery, and improves the quality of life of the patients.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neck / surgery. Neck Dissection / methods. Tongue Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Male. Neoplasm Staging. Treatment Outcome

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  • (PMID = 18067839.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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64. Asghar AH, Mahmood H, Faheem M, Rizvi S, Khan KA, Irfan J: Porocarcinoma: a rare sweat gland malignancy. J Coll Physicians Surg Pak; 2009 Jun;19(6):389-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine Porocarcinoma (ECP) is a malignant tumour arising from the intraepithelial ductal parts of the sweat gland.
  • It has also been described as malignant hidroacanthoma simplex, sweat gland carcinoma, malignant intra-epidermal eccrine poroma, eccrine poroepithelioma, dysplastic poroma, malignant syringo acanthoma and porocarcinoma.
  • Here, we present a case report of 52 years old male who presented with a fungating growth on left pre-auricular region that came out to be a case of ECP on histopathological examination.
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Doxorubicin / therapeutic use. Humans. Male. Middle Aged. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / drug therapy. Sweat Gland Neoplasms / surgery

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  • (PMID = 19486582.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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65. Bagherpour R, Mirfazaelian A, Mangoli AA, Alikhasi M: Prosthetic rehabilitation of intentionally malpositioned implants in a patient with squamous cell carcinoma of the external auditory canal: a clinical report. Implant Dent; 2009 Aug;18(4):291-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prosthetic rehabilitation of intentionally malpositioned implants in a patient with squamous cell carcinoma of the external auditory canal: a clinical report.
  • This clinical report describes the rehabilitation of a patient with a compromised temporal bone anatomy caused by resection of bone due to squamous cell carcinoma of external auditory canal.
  • Tumor resection was followed by placement of three implants.
  • Prosthodontic treatment included customized implant bar-supported auricular prosthesis.
  • [MeSH-major] Ear Neoplasms / rehabilitation. Ear, External. Prostheses and Implants. Prosthesis Implantation / instrumentation. Temporal Bone / surgery

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  • (PMID = 19667816.001).
  • [ISSN] 1538-2982
  • [Journal-full-title] Implant dentistry
  • [ISO-abbreviation] Implant Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Shan XF, Cai ZG, Zhang JG, Zhang J, Gao Y, Yu GY: Management of sialoblastoma with surgery and brachytherapy. Pediatr Blood Cancer; 2010 Dec 15;55(7):1427-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sialoblastoma is a rare congenital or perinatal salivary gland tumor with significant variability in histological appearance and biological behavior.
  • The tumor was excised with negative margins, and the sacrificed facial nerve was reconstructed with great auricular nerve graft.
  • The tumor recurred 6 months after operation and was treated with (125)I seed implant brachytherapy.
  • [MeSH-major] Brachytherapy. Parotid Neoplasms / therapy
  • [MeSH-minor] Facial Nerve / pathology. Female. Humans. Infant. Neoplasm Invasiveness. Neoplasm Recurrence, Local

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  • (PMID = 20734405.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Zarrin-Khameh N, Spoden JE, Tran RM: Angiolymphoid hyperplasia with eosinophilia associated with pregnancy: a case report and review of the literature. Arch Pathol Lab Med; 2005 Sep;129(9):1168-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of angiolymphoid hyperplasia with eosinophilia (ALH) is reported in a 33-year-old woman who developed an auricular nodule during the second trimester of her pregnancy.
  • The auricular tumor was completely excised.
  • Thirteen months after excision, the patient remains tumor free.
  • [MeSH-major] Angiolymphoid Hyperplasia with Eosinophilia / pathology. Ear Neoplasms / pathology. Eosinophils / pathology. Pregnancy Complications, Neoplastic / pathology
  • [MeSH-minor] Adult. Antigens, CD34 / metabolism. Arteriovenous Malformations / diagnosis. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Keratosis / diagnosis. Neurilemmoma / diagnosis. Pregnancy

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  • (PMID = 16119993.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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68. Sun W, Xu YD, Zheng YQ, Liu X, Zeng L, Liu W, Huang X: Endoscope-assisted partial-superficial parotidectomy through two small skin incisions. Acta Otolaryngol; 2009 Dec;129(12):1493-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSION: Endoscope-assisted partial-superficial parotidectomy is a feasible method for treatment of benign parotid superficial lobe tumors located at the anterior or the inferior of the auricular lobule.
  • The main advantage of this procedure is that the small operative scar resulted in improved cosmetic results.
  • PATIENTS AND METHODS: Thirty cases with benign parotid superficial lobe tumors with a diameter < 30 mm located at the anterior or the inferior of the auricular lobule underwent endoscope-assisted partial-superficial parotidectomy via retrograde approach through two small skin incisions.
  • RESULTS: All 30 operations were successfully performed endoscopically.
  • All the patients were satisfied with the cosmetic results.
  • There was no tumor recurrence during the follow-up after 26-50 months.
  • [MeSH-major] Endoscopy. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19922103.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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69. Roh JL, Kim HS, Park CI: Randomized clinical trial comparing partial parotidectomy versus superficial or total parotidectomy. Br J Surg; 2007 Sep;94(9):1081-7
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: In recent decades the treatment of benign parotid tumours has shifted from superficial or total parotidectomy to partial parotidectomy.
  • This study examined whether current surgical techniques improved functional outcomes after surgery for benign parotid tumours.
  • The latter consisted of modified facelift incision, greater auricular nerve preservation, partial parotidectomy and coverage with parotid fascia.
  • RESULTS: The mean duration of operation was 0.7 h shorter and the overall complication rate significantly lower in the functional surgery group.
  • In this group, more patients were satisfied with their scars and facial contours, the auricular nerve sensory recovery rate was high, and transient facial paralysis and Frey's syndrome were infrequent (12 and 6 per cent respectively).
  • There was no tumour recurrence in either group during a mean follow-up of 48 months.
  • CONCLUSION: Compared with conventional procedures, function-preserving surgery for benign parotid tumours improved cosmetic, sensory and salivary functions, and reduced the duration of surgery and operative morbidity.
  • [MeSH-major] Otorhinolaryngologic Surgical Procedures / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery. Patient Satisfaction. Postoperative Complications / prevention & control

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  • [Copyright] Copyright (c) 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 17701949.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
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70. Ren WH, Zhi KQ, Gao L, Xu Y, Li XQ, Shi MJ: [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors]. Shanghai Kou Qiang Yi Xue; 2010 Jun;19(3):232-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical utilization of veiled incision and sternocleidomastoid flap in parotidectomy of parotid benign tumors].
  • The follow-up period was 2 years, oncological recurrence was compared between the two groups.
  • The incidence of Frey's syndrome and the feeling of the region around the auricular lobule were evaluated.
  • RESULTS: During the follow up period, the patients in the group 1 showed better aesthetic results than those in the group 2 and without obvious scar and deformity.
  • There was no significant difference between these two groups in temporary facial paralysis, salivary fistula, tumor recurrence, Frey's syndrome, the feeling of the region around the auricular lobule.
  • CONCLUSION: The modified technique of parotidectomy using veiled incision and sternocleidomastoid flap greatly reduces the disadvantages of traditional parotidectomy and provides better aesthetic results.
  • [MeSH-minor] Ear Auricle. Face. Humans. Neoplasms. Parotid Neoplasms. Postoperative Complications. Surgical Flaps

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  • (PMID = 20635029.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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71. Bojanović M, Zivković-Marinkov E, Veselinović D, Bojanović A, Vucković I: [Malignant tumors of auricula and periauricular area]. Vojnosanit Pregl; 2009 Aug;66(8):611-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant tumors of auricula and periauricular area].
  • BACKGROUND/AIM: Malignant tumors of auricula and periauricular area represent seven percent of all cutaneous tumors.
  • According to histological type they are basocellular and planocellular carcinomas.
  • The aim of this study was to analyze clinical and histological characteristics and therapy of malignant tumors of auricular and periauricular area.
  • RESULTS: Since the majority of tumors were small and presented on the helix, wedge excision and primary reconstruction were performed (136), while total (9) or partial (10) auriculectomy were done in a small number of the patients.
  • CONCLUSION: Carcinoma of auricular and periauricular area should be confirmed by biopsy and histopathologic evaluation.
  • [MeSH-major] Ear Neoplasms. Ear, External. Skin Neoplasms

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  • (PMID = 19780414.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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72. Zhi KQ, Deng PF, Ren WH, Zhang L, Li XQ, Wen YM: [A clinical retrospective study on modified parotidectomy in benign tumors of parotid gland]. Shanghai Kou Qiang Yi Xue; 2008 Jun;17(3):229-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A clinical retrospective study on modified parotidectomy in benign tumors of parotid gland].
  • Group 2(55 cases) was treated with preserving the fascia parotideomasseterica and great auricular nerve and partial parotidectomy.
  • Tumor size, blood loss, operating time, temporary facial paralysis, tumour recurrence were compared between the two groups.
  • The incidence of Frey's syndrome was clinically evaluated by Minor test (starch-iodine test).
  • The feeling of the region around the auricular lobule was also evaluated.
  • RESULTS: There was no significant difference between the two groups in tumor size, temporary facial paralysis and tumor recurrence.
  • The incidence rate of Frey's syndrome in Group 1 was significantly lower than that in Group 2 by objective observation and Minor test.
  • There was significant difference between the feeling of pro- operation and pre-operation in the auricular lobule.
  • CONCLUSIONS: The modified parotidectomy is a function-preserving surgery for benign parotid tumours, which improves the cosmetics, the feeling around ear, reduces the duration of surgery, and the incidence rate of Frey's syndrome.
  • [MeSH-minor] Ear Auricle. Face. Facial Paralysis. Humans. Postoperative Complications. Retrospective Studies. Sweating, Gustatory

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  • (PMID = 18661059.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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73. Naumann IC, Miyamoto RT: Large asymptomatic pneumocephalus developing years after middle cranial fossa surgery--a case report. Auris Nasus Larynx; 2009 Aug;36(4):470-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a patient with a supra-auricular soft-tissue swelling as the only presenting symptom of a large chronic epidural pneumocele with extension into the extracranial subcutaneous tissues.
  • It presented several years after surgical resection of a meningioma that involved the temporal bone.
  • [MeSH-major] Cranial Fossa, Middle / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Pneumocephalus / etiology. Postoperative Complications

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  • (PMID = 19097717.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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74. Manganaris A, Kiziridou A, Manganaris T: Unusual localization of an adenoid cystic carcinoma subsequent to superficial parotidectomy for a benign lesion. J Craniofac Surg; 2007 Jan;18(1):231-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual localization of an adenoid cystic carcinoma subsequent to superficial parotidectomy for a benign lesion.
  • According to a retrospective study of the medical records and histopathology files of 514 cases of parotid tumors operated at our hospital over a period of 18 years, adenoid cystic carcinoma represented only 2.3% of all parotid gland neoplasms, a total of 12 cases.
  • In our records we retrieved only one documented case of adenoid cystic carcinoma that originated in the parotid gland subsequent to superficial parotidectomy for a benign lesion (pleomorphic adenoma).
  • An even more exceptional presentation of adenoid cystic carcinoma is as a bilobed tumor extending from the post auricular to the temporal and zygomatic region.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17251870.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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75. Horta RM, Barbosa R, Marques M, Rebelo M, Ferreira A, Reis JC, Amarante JM: Reconstruction of middle third defects of the face with the temporal flap. Ann Plast Surg; 2009 Sep;63(3):288-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It has shown important results on the facial reanimation and in oncological surgery.
  • This flap allows the covering of bone and noble structures such as the periorbital, auricular, frontal, or parotid gland areas.
  • Few major or minor complications were seen and good aesthetic results were achieved.
  • The patient prognosis however, depends on the stage of the tumor.
  • [MeSH-major] Face / surgery. Head and Neck Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps / blood supply. Temporal Muscle / transplantation

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  • (PMID = 19692893.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Li G, Chang S, Adler JR Jr, Lim M: Irradiation of glomus jugulare tumors: a historical perspective. Neurosurg Focus; 2007;23(6):E13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Irradiation of glomus jugulare tumors: a historical perspective.
  • Glomus jugulare tumors are rare, slow-growing vascular lesions that arise from the chief cells of the paraganglia within the jugular bulb.
  • They can be associated with the tympanic branch of the glossopharyngeal nerve (Jacobsen nerve) or the auricular branch of the vagus nerve (Arnold nerve) and are also referred to as chemodectomas or nonchromaffin paragangliomas.
  • Optimal treatment of these histologically benign tumors remains controversial.
  • External-beam radiation was originally used for subtotal resections and in patients who were poor surgical candidates; however, radiosurgery has recently been introduced as an effective and safe treatment option for patients with these tumors.
  • In this article the authors discuss the history of radiation therapy for glomus jugulare tumors, focusing on recent radiosurgical results.
  • [MeSH-major] Glomus Jugulare Tumor / radiotherapy. Glomus Jugulare Tumor / surgery. Radiosurgery / history. Radiosurgery / methods

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  • (PMID = 18081478.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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77. Civelek AC, Patel P, Ozalp E, Brem RF: Tc-99m sestamibi uptake in the chest mimicking a malignant lesion of the breast. Breast; 2006 Feb;15(1):111-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tc-99m sestamibi uptake in the chest mimicking a malignant lesion of the breast.
  • It's use is becoming more widespread, particularly as breast optimized scintigraphy with a high-resolution, breast-specific gamma camera has been developed (J. Nucl. Med.
  • This report describes a previously unrecognized cause for a false positive interpretation of scintimammography due to tumor uptake of the radiotracer in the chest as a result of physiologic activity in the auricular aspect of the right atrium.
  • [MeSH-major] Breast Neoplasms / radionuclide imaging. Radiopharmaceuticals / pharmacokinetics. Technetium Tc 99m Sestamibi / pharmacokinetics

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  • (PMID = 16473742.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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78. Gilani JA, Ullah Khan A, Shahid S, Ullah Khan I, Ullah Khan S: Clinical presentation of non-HIV Kaposi Sarcoma. J Coll Physicians Surg Pak; 2009 Sep;19(9):586-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical presentation of non-HIV Kaposi Sarcoma.
  • In the north west of Pakistan and Afghanistan, we mostly come across non-HIV related Kaposi sarcoma as Human Immunodeficiency Virus (HIV).
  • Here, we present a case of a non-auto Immunodeficiency Disease (AIDS) related KS.
  • A 45-year-old male, Afghan patient presented to our oncology outpatient's unit with multiple subcutaneous nodules.
  • The sites of involvement were the periorbital region, retro-auricular region, forearms, legs, chest and back.
  • A biopsy specimen from the retro-auricular region revealed a KS with dermal lymphatic involvement.
  • His serum was negative for the common types of viral infections including Human Immunodeficiency Virus (HIV) on routine serology.
  • [MeSH-major] Sarcoma, Kaposi / drug therapy. Sarcoma, Kaposi / pathology

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  • (PMID = 19728948.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 11056-06-7 / Bleomycin; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin
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79. Ghosh SK, Bandyopadhyay D, Gupta S, Chatterjee G, Ghosh A: Rapidly growing extraocular sebaceous carcinoma occurring during pregnancy: a case report. Dermatol Online J; 2008;14(8):8
MedlinePlus Health Information. consumer health - Tumors and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous carcinoma is a very rare, aggressive, malignant tumor derived from the adnexal epithelium of sebaceous glands.
  • It is traditionally classified into two groups: tumors arising from the ocular adnexa and those arising in extra-ocular sites.
  • Extraocular sebaceous carcinoma in the post-auricular region or in the external auditory canal is very rarely described in the literature.
  • A case of a rapidly growing sebaceous carcinoma of the pinna occurring in a pregnant woman is reported here for its rarity.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Ear Neoplasms / pathology. Ear, External / pathology. Pregnancy Complications, Neoplastic / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Pregnancy

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  • (PMID = 19061568.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Martins WD, Fávaro DM: Aneurysmal bone cyst of the coronoid process of the mandible: a case report. J Contemp Dent Pract; 2005 May 15;6(2):130-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aneurysmal bone cyst of the coronoid process of the mandible: a case report.
  • A rare case of aneurysmal bone cyst (ABC) located in the ramus of the mandible with involvement of the coronoid process is presented.
  • The pressure of the slow growing tumor apparently caused severe resorption of the zigomatic arch.
  • Treatment consisted of enucleation of the tumor via a pre-auricular access.
  • [MeSH-major] Bone Cysts, Aneurysmal / pathology. Mandibular Diseases / pathology

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  • (PMID = 15915212.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Mitra R: Osteitis Condensans Ilii. Rheumatol Int; 2010 Jan;30(3):293-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteitis Condensans Ilii (OCI) is a benign cause of axial low back pain.
  • Although no clear etiology has been identified, the prevailing theory is that mechanical strain affects the auricular portion of the ilium and causes premature arthritis.
  • Clinicians must be guided by history, radiographic findings, and laboratory studies in differentiating OCI with other disorders; furthermore additional causes of low back pain including metastatic disease and ankylosing spondylitis must be ruled out.
  • Treatments for the condition are primarily conservative (therapies, non-steroidal anti-inflammatory medications, and steroid injections), with surgical resection being reserved for refractory cases.
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Diagnosis, Differential. Humans. Neoplasm Metastasis / diagnosis. Radiography. Radiology. Sacroiliac Joint / diagnostic imaging. Sacroiliac Joint / pathology. Sacroiliac Joint / physiopathology. Spondylitis, Ankylosing / diagnosis. Steroids / therapeutic use

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  • [Cites] Chir Organi Mov. 1989 Jul-Dec;74(3-4):101-7 [2635651.001]
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  • (PMID = 19711079.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Steroids
  • [Number-of-references] 24
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82. Bellew S, Del Rosso JQ, Mobini N: Primary carcinosarcoma of the ear: case report and review of the literature. J Clin Aesthet Dermatol; 2009 Aug;2(8):33-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary carcinosarcoma of the ear: case report and review of the literature.
  • Primary carcinosarcoma is a very rare neoplasm comprising two intermingling malignant components-epithelial and mesenchymal.
  • The authors report a new case of primary cutaneous carcinosarcoma involving the helix of the ear.
  • Immunohistochemical analysis revealed epithelial components of both basal cell and squamous cell carcinomas with a partially ossified sarcomatous-like component.Cutaneous carcinosarcoma (CS) is a neoplasm with dual epithelial and mesenchymal malignant components.
  • Immunohistochemistry plays an integral part in the diagnosis of this rare biphasic neoplasm.
  • After a review of the literature, the authors were able to find only four other reported cases of CS involving the ear.(1,3) They present the fifth case of primary cutaneous CS, which involved the helix of the ear.

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  • (PMID = 20729953.001).
  • [ISSN] 1941-2789
  • [Journal-full-title] The Journal of clinical and aesthetic dermatology
  • [ISO-abbreviation] J Clin Aesthet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923961
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83. Marmulla R, Eggers G, Mühling J: Laser surface registration for lateral skull base surgery. Minim Invasive Neurosurg; 2005 Jun;48(3):181-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The present study was designed to evaluate whether the auricles may serve as an accurate spatial reference for markerless patient registration in image-guided lateral skull base surgery.
  • STUDY DESIGN: In a prospective clinical study, the precision of markerless patient registration was checked by using periauricular evaluation markers and additional distant oral evaluation markers that served as targets for the infrared pointer of a navigation system.
  • Ten patients with cranial tumors, bony malformations, or foreign bodies who were planned for image-guided surgery were selected.
  • RESULTS: Based on the auricle, a high accuracy (mean target detection error tde = 0.9 mm +/- s = 0.3 mm) was achieved in markerless patient registration as long as the auricle was not deformed during CT imaging or during laser scanning.
  • However, the conventional CT acquisition with a head support caused temporary auricular deformations in half of the patients, which made a precise laser-scan registration impossible.
  • Constantly good results can be achieved if the head support of the computer tomograph has an appropriate opening at the level of the auricles in order to avoid auricular deformations during CT acquisition.
  • [MeSH-major] Ear. Lasers. Neuronavigation / methods. Skull Base / surgery. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Adult. Algorithms. Calibration. Foreign Bodies / surgery. Humans. Male. Reproducibility of Results. Skull Base Neoplasms / surgery

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  • (PMID = 16015497.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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84. Gharehbaghi MM, Ghaemi MR: Goldenhar syndrome in an infant of diabetic mother. Iran J Pediatr; 2010 Mar;20(1):131-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goldenhar syndrome in an infant of diabetic mother.
  • BACKGROUND: Goldenhar syndrome (oculoauriculovertebral dysplasia) is a rare congenital anomaly with unknown etiology and consists of non accidental association of hemifacial microsomia, auricular anomalies, epibulbar dermoid and vertebral anomalies.
  • Although some malformations are more frequent in infants of diabetic mothers, developmental defects of first and second branchial arch is not a common finding in these patients.
  • CASE PRESENTATION: We report a female case of Goldenhar syndrome in a newborn infant of a diabetic mother (IDM).
  • She had developed epibulbar dermoid tumor in her right eye.

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  • (PMID = 23056696.001).
  • [ISSN] 2008-2142
  • [Journal-full-title] Iranian journal of pediatrics
  • [ISO-abbreviation] Iran J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3445997
  • [Keywords] NOTNLM ; Congenital Defects / Gestational Diabetes / Goldenhar Syndrome / Oculoauriculovertebral Syndrome
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85. de Ru JA, van Benthem PP, Hordijk GJ: Morbidity of parotid gland surgery: results 1 year post-operative. Eur Arch Otorhinolaryngol; 2006 Jun;263(6):582-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morbidity of parotid gland surgery: results 1 year post-operative.
  • Patients operated on for parotid gland tumours were evaluated prospectively to study morbidity after this procedure.
  • Nowadays, major complications such as recurrence of tumour and permanent facial nerve paresis are rare after primary surgery.
  • Therefore, this study especially takes minor complications such as Frey's syndrome and sensory deficits into account.
  • Among those with primary benign tumours, we found no recurrences and no permanent paresis, nor did starch-iodine testing reveal any cases of Frey's syndrome.
  • However, two patients who had previously been operated on multiple times did test positive for Frey's syndrome, as did two others after surgery for malignancy.
  • Furthermore, we found that patients whose posterior branch of the great auricular nerve was sacrificed had a larger area of sensory deficit than those whose nerve was preserved.
  • [MeSH-major] Parotid Gland / surgery. Parotid Neoplasms / mortality. Parotid Neoplasms / surgery

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  • [Cites] Mund Kiefer Gesichtschir. 2001 Mar;5(2):144-9 [11372182.001]
  • (PMID = 16506039.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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86. Torres Gómez FJ, Torres Olivera FJ: [Synchronous malignant fibrous histiocytomas in ileal and atrial locations]. Gastroenterol Hepatol; 2008 Jan;31(1):22-4
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  • [Title] [Synchronous malignant fibrous histiocytomas in ileal and atrial locations].
  • [Transliterated title] Histiocitoma fibroso maligno de localización sincrónica ileal y auricular.
  • Diagnosis of malignant fibrous histiocytoma in ileal and atrial locations is uncommon and diagnosis of synchronous lesions in both locations is exceptional.
  • We present the case of a 60-year-old woman with a malignant fibrous histiocytoma in both locations.
  • Malignant fibrous histiocytoma is an aggressive neoplasm.
  • [MeSH-major] Heart Atria. Heart Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology. Ileal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18218276.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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87. Cribier B, Scrivener Y, Peltre B: Neural hyperplasia in chondrodermatitis nodularis chronica helicis. J Am Acad Dermatol; 2006 Nov;55(5):844-8
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  • As controls, we investigated 25 tumors of the ear with the same methods.
  • RESULTS: Large nerves (>0.1 mm in diameter) were seen in 8 of 37 cases; these were close to the cartilage or at the upper part of the ulceration.
  • Nerve hyperplasia was not observed in tumors of the ear, even in ulcerated cases.
  • LIMITATIONS: Hypothesis based on morphologic observations.
  • This finding may explain the induction of pain by light pressure, whereas ulcerated auricular malignant tumors are generally painless.
  • [MeSH-major] Cartilage Diseases / pathology. Dermatitis / pathology. Ear Cartilage / innervation. Ear Diseases / pathology. Ear, External / innervation. Nerve Tissue / pathology

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  • (PMID = 17052491.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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88. Kopyl SA, Dorogova NV, Akhmamet'eva EM, Omel'ianchuk LV, Chang L-: [Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap]. Genetika; 2010 Mar;46(3):314-20
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  • The protein Merlin is involved in the regulation of cell proliferation and differentiation in the eyes and wings of Drosophila and is a homolog of the human protein encoded by the Neurofibromatosis 2 (NF2) gene whose mutations cause auricular nerve tumors.
  • Recent studies show that Merlin and Expanded cooperatively regulate the recycling of membrane receptors, such as the epidermal growth factor receptor (EGFR).
  • On the one hand, coexpression of wild-type Merlin and lap in the wing pouch restored normal venation, while overexpression of a dominant-negative mutant Mer(DBB) together with lap enhanced ectopic vein formation.
  • [MeSH-minor] Animals. Cell Proliferation. Clathrin / genetics. Clathrin / metabolism. Drosophila Proteins / genetics. Drosophila Proteins / metabolism. Drosophila melanogaster. Ear Neoplasms / genetics. Ear Neoplasms / metabolism. Eye / embryology. Humans. Membrane Proteins / genetics. Membrane Proteins / metabolism. Peripheral Nervous System Neoplasms / genetics. Peripheral Nervous System Neoplasms / metabolism. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism. Receptors, Invertebrate Peptide / genetics. Receptors, Invertebrate Peptide / metabolism. Wings, Animal / embryology

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  • (PMID = 20391775.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Adaptor Proteins, Vesicular Transport; 0 / Clathrin; 0 / Drosophila Proteins; 0 / Membrane Proteins; 0 / Neurofibromin 2; 0 / Receptors, Invertebrate Peptide; 0 / expanded protein, Drosophila; 0 / merlin, Drosophila; EC 2.7.10.1 / Egfr protein, Drosophila; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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89. Halin C, Tobler NE, Vigl B, Brown LF, Detmar M: VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood; 2007 Nov 1;110(9):3158-67
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  • Lymphangiogenesis is involved in tumor cell metastasis and plays a major role in chronic inflammatory disorders.
  • To investigate the role of lymphangiogenesis in inflammation, we induced and maintained delayed-type hypersensitivity (DTH) reactions in the ears of mice and then analyzed the resulting lymphangiogenesis in the inflamed tissue and draining lymph nodes (LNs) by quantitative fluorescence-activated cell sorting (FACS) and by immunofluorescence.
  • Long-lasting inflammation induced a significant increase in the number of lymphatic endothelial cells, not only in the inflamed ears but also in the ear-draining auricular LNs.
  • Inflammation-induced lymphangiogenesis was potently blocked by systemic administration of a vascular endothelial growth factor (VEGF)-A neutralizing antibody.
  • These findings were explained by analysis of both VEGF-A protein and mRNA levels, which revealed that VEGF-A was expressed at high mRNA and protein levels in inflamed ears but that expression was increased only at the protein level in activated LNs.
  • Inflammation-induced lymphangiogenesis in LNs was independent of the presence of nodal B lymphocytes, as shown in B cell-deficient mice.

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  • (PMID = 17625067.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA092644; United States / NCI NIH HHS / CA / R01 CA069184; United States / NCI NIH HHS / CA / CA 69184; United States / NCI NIH HHS / CA / CA 92644
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 0 / vascular endothelial growth factor A, mouse
  • [Other-IDs] NLM/ PMC2200913
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90. Njim L, Dhouibi A, Touil N, Lahmar I, Hadhri R, Moussa A, Zakhama A: Benign osteoblastoma in an unusual mastoid location. Eur Ann Otorhinolaryngol Head Neck Dis; 2010 Nov;127(5):183-5
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  • [Title] Benign osteoblastoma in an unusual mastoid location.
  • INTRODUCTION: Benign osteoblastoma (OB) is an unusual primary bone tumor.
  • CASE REPORT: A 22-year-old woman presented with painful left retro-auricular swelling.
  • The pathologic examination of bone curettage material revealed a benign OB.
  • A complete resection of the tumor was performed later, with no evidence of recurrence at 1 year.
  • Although generally regarded as benign, OB has potential for recurrence and local invasion.
  • [MeSH-major] Bone Neoplasms / diagnosis. Mastoid. Osteoblastoma / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20951662.001).
  • [ISSN] 1879-730X
  • [Journal-full-title] European annals of otorhinolaryngology, head and neck diseases
  • [ISO-abbreviation] Eur Ann Otorhinolaryngol Head Neck Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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91. Chistiakov AL, Klochikhin AL, Al-Kharbi AA: [Reconstructive surgical treatment of nasal skin cancer]. Vestn Otorinolaringol; 2010;(1):52-5
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  • Results of reconstructive surgical treatment of malignant nasal skin tumours in 96 patients (46 men and 50 women) are presented.
  • All of them underwent surgery including extensive excision of the affected nasal skin.
  • The postoperative defect was substituted by the following varieties of grafts: sliding cellulocutaneous flap (n=38), rotation cellulocutaneous buccal flap (n=36), free full-thickness flap (n=2), free chondrocutaneous flap (n=5), cutaneous-aponeurotic forehead flap (n=2), composite graft (cellulocutaneous buccal flap with a fragment of free auricular cartilage) (n=13).
  • A new modification of reconstructive surgical treatment was proposed to correct a through defect of the nasal ala using a rotation cellulocutaneous buccal flap.
  • The frequency of continued growth or relapse of nasal skin tumours following plastic reconstruction by different methods was 7.3%.
  • The new variant of reconstructive treatment of through defects in the nasal alae ensures efficacious healing of the postoperative wound and a good cosmetic result.
  • [MeSH-major] Mouth Mucosa / transplantation. Nose Neoplasms / surgery. Rhinoplasty / methods. Skin Neoplasms / surgery. Skin Transplantation / methods. Surgical Flaps

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  • (PMID = 20436425.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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92. Geibprasert S, Pongpech S, Armstrong D, Krings T: Dangerous extracranial-intracranial anastomoses and supply to the cranial nerves: vessels the neurointerventionalist needs to know. AJNR Am J Neuroradiol; 2009 Sep;30(8):1459-68

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Transarterial embolization in the external carotid artery (ECA) territory has a major role in the endovascular management of epistaxis, skull base tumors, and dural arteriovenous fistulas.
  • To avoid cranial nerve palsy, one must have knowledge of the supply to the lower cranial nerves: The petrous branch of the middle meningeal artery and the stylomastoid branch of the posterior auricular artery form the facial arcade as the major supply to the facial nerve, and the neuromeningeal trunk of the ascending pharyngeal artery supplies the lower cranial nerves (CN IX-XII).

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  • (PMID = 19279274.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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93. Hox V, Vander Poorten V, Delaere PR, Hermans R, Debiec-Rychter M, Sciot R: Extramammary myofibroblastoma in the head and neck region. Head Neck; 2009 Sep;31(9):1240-4
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  • BACKGROUND: Mammary myofibroblastoma is a benign mesenchymal tumor of the breast.
  • METHODS AND RESULTS: In this article, we present a case of a woman with an infra-auricular swelling.
  • CONCLUSION: We describe this case because of the unusual location of this rare tumor.
  • Both tumors show the same clinical behavior, a close histological resemblance, and their cells are both immunoreactive for CD34 and CD10.
  • [MeSH-major] Head and Neck Neoplasms. Neoplasms, Muscle Tissue

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  • (PMID = 19132718.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Roy S, Dhingra KK, Gupta P, Khurana N, Gupta B, Meher R: Acinic cell carcinoma with extensive neuroendocrine differentiation: a diagnostic challenge. Head Neck Pathol; 2009 Jun;3(2):163-8
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  • Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor.
  • A 48 year old lady presented with a gradually increasing right infra-auricular swelling for a period of 1 year which enlarged suddenly in a short period.
  • Fine Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin's tumor or Oncocytic lesion.
  • Intraoperative findings were suggestive of a Warthin's tumor.
  • Initial histopathological examination of the tumor was suggestive of neuroendocrine carcinoma.
  • Immunoexpression of S-100, Neuron specific Enolase (NSE), Chromogranin A and Synaptophysin confirmed the diagnosis.
  • The possibility of neuroendocrine differentiation in a primary salivary gland tumor should be kept in mind whenever a salivary gland tumor shows only neuroendocrine histology.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19644544.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Acinic cell / Carcinoma / Chromogranin / Neuroendocrine / Parotid / Warthin’s
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95. Huang X, Zheng Y, Liu X, Sun W, Zeng L, Cai X, Liu W, Xu Y, Zhang Z, Huang H: A comparison between endoscope-assisted partial parotidectomy and conventional partial parotidectomy. Otolaryngol Head Neck Surg; 2009 Jan;140(1):70-5
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  • RESULTS: The endoscopic surgery lasted for 108.61 +/- 11.86 minutes and the bleeding volume was significantly lower than in the conventional group.
  • All 18 patients were satisfied with their cosmetic results; 14 patients (65%) were satisfied with the great auricular nerve preservation; only one patient had temporary facial paresis and salivary fistula.
  • There was no tumor recurrence in both groups during the follow-up after 26 to 40 months) the endoscope-assisted parotidectomy group (median 30 months, range 26-40 months) and conventional group (median 32 months, range 26-40 months).
  • [MeSH-minor] Adult. Blood Loss, Surgical. Feasibility Studies. Female. Humans. Male. Parotid Neoplasms / surgery. Patient Satisfaction. Time Factors. Ultrasonic Therapy

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  • (PMID = 19130965.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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96. Chen WL, Fang SL: Removal of second branchial cleft cysts using a retroauricular approach. Head Neck; 2009 May;31(5):695-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Removal of second branchial cleft cysts using a retroauricular approach.
  • BACKGROUND: Second branchial cleft cysts (also called cervical lymphoepithelial cysts) usually present in adulthood, and cosmesis of surgical access is an important issue.
  • This study was performed to assess the feasibility and outcome of a retroauricular approach for removing second branchial cleft cysts.
  • METHODS: Eight patients underwent removal of second branchial cleft cysts using a retroauricular approach.
  • RESULTS: All 8 second branchial cleft cysts were removed successfully, and the wounds healed uneventfully.
  • None of the patients suffered from weakness of the great auricular nerve.
  • Average follow-up period was 14.5 months (range, 6-20 months) with no tumor recurrence.
  • CONCLUSION: Second branchial cleft cyst resection using a retroauricular approach is a feasible method that provides an acceptable cosmetic outcome.
  • [MeSH-major] Branchioma / surgery. Esthetics. Head and Neck Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods

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  • (PMID = 19189334.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Yune TY, Byun JY: Expression of PTEN and phosphorylated Akt in human cholesteatoma epithelium. Acta Otolaryngol; 2009 May;129(5):501-6
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  • CONCLUSION: We found a reduced PTEN and an increased phosphorylated Akt (p-Akt) expression in cholesteatoma epithelium when compared with retro-auricular (RA) skin.
  • The negative correlation between cholesteatoma PTEN and p-Akt may suggest that cellular survival mechanisms may be involved in cholesteatoma epithelial hyperplasia.
  • OBJECTIVES: The tumor suppressor PTEN regulates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway and modulates cell cycle progression and cell survival.
  • MATERIALS AND METHODS: Western blotting and immunohistochemistry were used to examine the expression of PTEN and p-Akt in 16 cases of cholesteatoma and paired cases of RA skin.
  • RESULTS: In cholesteatoma, p-Akt expression was significantly higher than in RA skin, whereas PTEN expression was significantly lower in cholesteatoma when compared with skin (p < 0.05).
  • Also, strong p-Akt immunoreactivity was observed in the cytoplasm of cholesteatoma epithelium, whereas very weak or no p-Akt immunoreactivity was observed in the RA skin.
  • Furthermore, we found that a significant inverse correlation exists between PTEN and p-Akt expression (r = -0.796).
  • [MeSH-major] Cholesteatoma, Middle Ear / metabolism. PTEN Phosphohydrolase / metabolism. Proto-Oncogene Proteins c-akt / metabolism

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  • (PMID = 18615333.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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98. Yeh SY, Chao TK: Leiomyoma of the external auditory canal--a case report and brief review of the literature. Eur Arch Otorhinolaryngol; 2005 May;262(5):397-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 47-year-old male with left external auditory canal leiomyoma presented with conductive hearing impairment and post-auricular swelling.
  • Tumor excision was successful via a retroauricular approach.
  • The pathological examination demonstrated a vascular leiomyoma without malignant change.
  • To date, including our case, only three cases of external auditory canal leiomyoma have been reported.
  • The tumor occurs mainly in adult males aged around 50 and should be included in the differential diagnoses for external auditory canal tumor.
  • In case of an external auditory canal tumor, even if it is believed to be benign before surgery, precise pathologic examination is required to exclude the possibility of malignancy.
  • [MeSH-major] Ear Canal / surgery. Ear Neoplasms / diagnosis. Ear Neoplasms / surgery. Leiomyoma / diagnosis. Leiomyoma / surgery

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  • [Cites] Acta Pathol Jpn. 1979 May;29(3):389-408 [222115.001]
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  • (PMID = 15368068.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 8
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99. Gentile P, Bottini DJ, Colicchia GM, Trimarco A, Cervelli V: Burns: bone-anchored, extra-oral implantology. J Burn Care Res; 2008 Jul-Aug;29(4):627-31
MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extra-oral implants represent a valid alternative technique in aesthetic reconstruction of the craniofacial district in oncology surgery.
  • Two female patients were selected; they were treated from December 2001 to June 2007 by implanting auricular epithesis.
  • No complications were observed, including bleeding and infections, in the postsurgery period.
  • [MeSH-major] Burns / surgery. Ear Auricle / surgery. Prostheses and Implants. Reconstructive Surgical Procedures / methods

  • MedlinePlus Health Information. consumer health - Burns.
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  • (PMID = 18535470.001).
  • [ISSN] 1559-047X
  • [Journal-full-title] Journal of burn care & research : official publication of the American Burn Association
  • [ISO-abbreviation] J Burn Care Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Khafif A: [Recurrent pleomorphic adenoma of the parotid gland]. Harefuah; 2007 Feb;146(2):111-2, 165

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Resection of such recurrences is associated with an increased risk of facial nerve injury and a higher incidence of recurrent disease.
  • Resection of the primary tumor with a cuff of normal tissue around it during the primary surgical resection lowers the incidence of such metastases, but even with them, metastases still occur.
  • Intraoperative monitoring of the facial nerve may be of help during these surgical interventions, but the surgeon need not rely on the monitor only, but identify the nerve based on its well known anatomy and use the monitor as another surgical tool for safe removal of the tumor.
  • In these cases, the nerve should be reconstructed with a cable graft (mainly greater auricular or sural) when possible.
  • Radiotherapy is reserved for patients that had multiple recurrences or had massive tumor spillage during their surgical procedure of the recurrent tumor.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery
  • [MeSH-minor] Humans. Neoplasm Metastasis. Recurrence

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  • (PMID = 17352279.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] Israel
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