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6. Balbani AP, Montovani JC: Mobile phones: influence on auditory and vestibular systems. Braz J Otorhinolaryngol; 2008 Jan-Feb;74(1):125-31
MedlinePlus Health Information. consumer health - Electromagnetic Fields.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mobile phones: influence on auditory and vestibular systems.
  • METHODS: We reviewed papers on the influence of mobile phones on auditory and vestibular systems from Lilacs and Medline databases, published from 2000 to 2005, and also materials available in the Internet.
  • Some authors did not see evidences of a higher risk of tumor development in mobile phone users, while others report that usage of analog cellular phones for ten or more years increase the risk of developing the tumor.
  • [MeSH-major] Auditory Perceptual Disorders / etiology. Cell Phones. Electromagnetic Fields / adverse effects. Neuroma, Acoustic / etiology. Otoacoustic Emissions, Spontaneous / radiation effects. Vestibule, Labyrinth / radiation effects

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  • [ErratumIn] Rev Bras Otorrinolaringol (Engl Ed). 2008 Mar-Apr;74(2):319
  • (PMID = 18392513.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 30
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7. Kameswaran M, Vasudevan MC, Kumar RS, Nagasundaram J, Natarajan K, Raghunandhan S: Auditory brainstem implantation: The first Indian experience. Indian J Otolaryngol Head Neck Surg; 2005 Jan;57(1):58-63

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory brainstem implantation: The first Indian experience.
  • Multichannel auditory brainstem implants (ABI) are currently indicated for patients with neurofibromatosis type II (NF2) involving both vestibulocochlear nerves.
  • The ABI helps bypass the damaged cochlear nerves and restores a level of auditory sensation via the electrical stimulation of the cochlear nucleus.
  • The implant is usually placed in the lateral recess of the fourth ventricle at the time of tumor resection to stimulate the cochlear nucleus.

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  • [Cites] J Laryngol Otol Suppl. 2000;(27):11-4 [11211429.001]
  • [Cites] J Laryngol Otol Suppl. 2000;(27):23-6 [11211432.001]
  • [Cites] J Laryngol Otol Suppl. 2000;(27):3-7 [11211434.001]
  • [Cites] Otol Neurotol. 2004 Jul;25(4):485-96; discussion 496 [15241227.001]
  • [Cites] Otol Neurotol. 2003 Jan;24(1):79-82 [12544033.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2004 May;130(5):656-9 [15148193.001]
  • [Cites] Laryngoscope. 2004 Dec;114(12):2135-46 [15564834.001]
  • [Cites] J Laryngol Otol Suppl. 2000;(27):8-10 [11211442.001]
  • (PMID = 23120129.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451539
  • [Keywords] NOTNLM ; auditory brainsterm unplants / neurofibromatosis
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8. Kim SM, Cho YB, Haider MA, Milosevic M, Yeung IWT: Multiphasic contrast injection for improved precision of parameter estimates in functional CT. Med Phys; 2008 Dec;35(12):5921-5933

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The covariance matrix analysis was applied to calculate the uncertainty of parameter estimates as the coefficients of variation (CV) in the adiabatic tissue homogeneity (ATH), two-compartment, and the modified Kety model in which tumor pathophysiology is modeled.
  • In addition, the robustness of the recommended injection protocol to longitudinal study has been investigated in the presence of variations in arterial input function and tumor pathophysiology.
  • The effect of variation in the arterial input function and tumor pathophysiology on the applicability of the recommended injection was also investigated.

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  • [Copyright] © 2008 American Association of Physicists in Medicine.
  • (PMID = 28525135.001).
  • [ISSN] 2473-4209
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Analytical theories / Auditory threshold / Biomedical modeling / Cancer / Computed tomography / Haemodynamics / Hemodynamics / Matrix theory / Medical image contrast / Medical image noise / Medical imaging / Numerical linear algebra / Physiology / Tissues / blood vessels / cancer / computerised tomography / contrast injection / covariance matrices / functional CT / haemodynamics / optimization / parameter estimation / physiological models / precision in kinetic parameters / recommended injection / tumours
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9. Colletti V: Auditory outcomes in tumor vs. nontumor patients fitted with auditory brainstem implants. Adv Otorhinolaryngol; 2006;64:167-85
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory outcomes in tumor vs. nontumor patients fitted with auditory brainstem implants.
  • Auditory brainstem implants (ABIs) are currently indicated for patients older than 12 years with neurofibromatosis type 2 (NF2) who had bilateral schwannoma removed.
  • In the present chapter we report our recent findings in adult ABI patients and compare the psychophysical and speech perception outcomes in tumor with those in nontumor patients.
  • We demonstrate that the ABI can stimulate the central auditory system in a way that gives the ability of open set speech understanding, and can thus be indicated in nontumor adult patients who are not candidates for a cochlear implant.
  • All patients, except 1 (NF2), reported auditory sensations with activation of various numbers of electrodes (from 5 to 21).
  • At 1 year after implantations nontumor adults scored from 12 to 100% in open set speech perception tests (average 59%), and tumor (NF2) patients scored from 5 to 30% (average of 11%).
  • To investigate the cause of the differences in performance between tumor and nontumor ABI recipients, a series of psychophysical tests were done consecutively in 39 adult patients with implants (25 nontumor and 14 tumor patients) from May 1999 to April 2004 and with a follow-up of at least 1 year.
  • (1) The ABIs allow most tumor and nontumor patients to experience improved communication as well as awareness of environmental sounds. (2) Nontumor patients had better hearing outcomes than tumor patients when the variation in the auditory benefit with the ABI in relation to the patient's underlying pathological conditions were taken into consideration. (3) A significant number of nontumor patients are able understand speech at a level comparable to that of the most successful cochlear implant users including conversational telephone use. (4) The ABI represents the tool for hearing rehabilitation in patients with profound hearing loss who cannot be fitted with cochlear implants.
  • [MeSH-major] Auditory Brain Stem Implants. Ear Neoplasms / surgery. Hearing Loss / surgery. Neurilemmoma / surgery. Neurofibromatosis 2 / surgery

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  • (PMID = 16891842.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 38
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10. Sone M, Katayama N, Otake N, Sato E, Fujimoto Y, Ito M, Nakashima T: Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals. J Clin Neurosci; 2007 May;14(5):470-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals.
  • We report the changes in auditory function in a patient with tumor metastasis to the bilateral internal auditory canals (IAC).
  • The hearing gradually deteriorated at frequencies below 1 kHz and above 4 kHz, with the auditory brainstem response (ABR) eventually becoming absent in both ears.
  • However, distortion product otoacoustic emissions (DPOAE) were present at low frequencies, which suggests that the organ of Corti in its upper turn remained unaffected by tumor invasion.
  • [MeSH-major] Cranial Nerve Neoplasms / physiopathology. Evoked Potentials, Auditory, Brain Stem / physiology. Neoplasm Metastasis / physiopathology. Otoacoustic Emissions, Spontaneous / physiology

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  • (PMID = 17386369.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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11. McCreery DB: Cochlear nucleus auditory prostheses. Hear Res; 2008 Aug;242(1-2):64-73
MedlinePlus Health Information. consumer health - Cochlear Implants.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cochlear nucleus auditory prostheses.
  • Persons who lack an auditory nerve cannot benefit from cochlear implants, but a prosthesis utilizing an electrode array implanted on the surface of the cochlear nucleus can restore some hearing.
  • Worldwide, more than 500 persons have received these "auditory brainstem implants," most commonly after removal of the tumors that occur with Type 2 Neurofibromatosis (NF2).
  • This suggests that the cochlear nuclei of the NF2 patients are damaged by the disease process or during surgical removal of the tumor.
  • [MeSH-major] Auditory Brain Stem Implants / trends. Cochlear Implants / trends. Cochlear Nucleus / physiology

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  • (PMID = 18207678.001).
  • [ISSN] 0378-5955
  • [Journal-full-title] Hearing research
  • [ISO-abbreviation] Hear. Res.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / N01-DC-2400; United States / NIDCD NIH HHS / DC / N01-DC-4-0005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
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12. Lassaletta L, Granell J, Patrón M, Gavilán J: Smooth muscle choristoma of the internal auditory meatus. Eur Arch Otorhinolaryngol; 2005 Oct;262(10):834-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Smooth muscle choristoma of the internal auditory meatus.
  • Choristomas of the internal auditory meatus are very uncommon tumors.
  • Surgical exploration usually shows involvement of the vestibular, cochlear or facial nerve by the tumor, representing a diagnostic and therapeutic challenge to the surgeon.
  • In this report, a case of a smooth muscle choristoma of the internal auditory meatus is presented.
  • Microscopic examination of the tumor revealed nerve fibers, smooth muscle and a small amount of adipose tissue.

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  • (PMID = 16187135.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Della Puppa A, Rossetto M, Berti F, Zustovich F, Manara R, Gardiman MP, Scienza R: Internal auditory canal metastasis. J Neurosurg Sci; 2010 Dec;54(4):159-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Internal auditory canal metastasis.
  • Metastasis of the inner auditory canal is a really rare event.
  • Intraoperatively, inner canal tumor looked totally involving the VII-VIII nerve complex so surgical extirpation was only partially feasible.
  • The case highlights the importance of maintaining a high degree of awareness of the auditory canal metastasis in patients with a previous history of malignancy who develop a rapid progressive peripheral VII nerve palsy.

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  • (PMID = 21423087.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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4. Mazurek B, Haupt H, Joachim R, Klapp BF, Stöver T, Szczepek AJ: Stress induces transient auditory hypersensitivity in rats. Hear Res; 2010 Jan;259(1-2):55-63
Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stress induces transient auditory hypersensitivity in rats.
  • Here, we examined the effect of above stress model on the auditory system of Wistar rats.
  • We found that 24-h stress decreases the thresholds and increases the amplitudes of auditory brainstem responses and distortion product otoacoustic emissions.
  • Resultant auditory hypersensitivity was transient and most pronounced between 3 and 6h post-stress, returning to control levels one week later.
  • The concentration of corticosterone and tumor necrosis factor alpha was systemically elevated in stressed animals between 3 and 6h post-stress, confirming the activation of the HPA axis.
  • In addition, expression of the HPA-axis-associated genes: glucocorticoid receptor (GR) and hypoxia-inducible factor 1 alpha (Hif1a) was modulated in the auditory tissues.
  • We conclude that 24-h stress induces transient hypersensitivity of the auditory system and modulates gene expression in a tissue-specific manner.
  • Stress-induced auditory hypersensitivity could have evolutionary consequence by giving animals an advantage of hearing better under stress conditions.
  • [MeSH-major] Auditory Threshold / physiology. Stress, Physiological / physiology
  • [MeSH-minor] Animals. Base Sequence. Biological Evolution. Corticosterone / blood. Cytokines / blood. DNA Primers / genetics. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Gene Expression. Hair Cells, Auditory, Outer / physiology. Hypothalamo-Hypophyseal System / physiology. Hypoxia-Inducible Factor 1, alpha Subunit / genetics. Inferior Colliculi / physiology. Organ of Corti / physiology. Otoacoustic Emissions, Spontaneous / physiology. Pituitary-Adrenal System / physiology. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rats. Rats, Wistar. Receptors, Glucocorticoid / genetics. Time Factors

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  • [Copyright] Copyright 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19840840.001).
  • [ISSN] 1878-5891
  • [Journal-full-title] Hearing research
  • [ISO-abbreviation] Hear. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cytokines; 0 / DNA Primers; 0 / Hif1a protein, rat; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; 0 / Receptors, Glucocorticoid; W980KJ009P / Corticosterone
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15. Colletti L, Zoccante L: Nonverbal cognitive abilities and auditory performance in children fitted with auditory brainstem implants: preliminary report. Laryngoscope; 2008 Aug;118(8):1443-8
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonverbal cognitive abilities and auditory performance in children fitted with auditory brainstem implants: preliminary report.
  • OBJECTIVES/HYPOTHESIS: Auditory brainstem implants (ABIs) can provide excellent open set speech recognition in adults without auditory tumors.
  • This article reports on the auditory performance and cognitive development measured in children with ABIs.
  • STUDY DESIGN: This study quantifies the development of auditory perceptual and nonverbal cognitive abilities of children with profound HL undergoing ABI.
  • From 2000 to 2006, 17 children aged 14 months to 16 years received an ABI for different tumor and nontumor diseases in our department in Verona, and nine children were operated in other countries.
  • Six of the children had been previously fitted elsewhere with a CI with no auditory results.
  • Intraoperative and postoperative electrically evoked auditory brainstem responses were performed in all children.
  • Perceptual auditory abilities were evaluated with the Evaluation of Auditory Responses to Speech battery and the Category of Auditory Performance test.
  • Their category of auditory performance test scores increased significantly with ABI use.
  • Postimplant cognitive outcomes were positively related to the auditory results.
  • [MeSH-major] Auditory Brain Stem Implants. Cognition Disorders / rehabilitation. Deafness / rehabilitation. Nonverbal Communication

  • MedlinePlus Health Information. consumer health - Hearing Disorders and Deafness.
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  • (PMID = 18496153.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Kuchta J: Twenty-five years of auditory brainstem implants: perspectives. Acta Neurochir Suppl; 2007;97(Pt 2):443-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Twenty-five years of auditory brainstem implants: perspectives.
  • The auditory brainstem implant (ABI) provides auditory sensations, recognition of environmental sounds and aid in spoken communication in more than 300 patients worldwide.
  • Auditory perceptual performance in patients who are deaf due to trauma, cochlea aplasia or other non-tumor lesions of the cochlea or the vestibulocochlear nerve turned out to be much better than in NF2 tumor patients.
  • Currently, new targets along the central auditory pathways and new, minimally invasive techniques for implantation are under investigation.
  • These techniques may further improve auditory perceptual performance in ABI patients and provide hearing to a variety of types of central deafness.
  • [MeSH-major] Auditory Brain Stem Implantation. Auditory Brain Stem Implants / trends

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  • (PMID = 17691334.001).
  • [ISSN] 0065-1419
  • [Journal-full-title] Acta neurochirurgica. Supplement
  • [ISO-abbreviation] Acta Neurochir. Suppl.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 25
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17. Kuczkowski J, Izycka-Swieszewska E, Plichta Ł, Cieszyńska J: [Combined tumor of ceruminous gland origin in the external auditory canal--a histopathological and immunohistochemical study]. Otolaryngol Pol; 2010 Nov-Dec;64(6):385-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combined tumor of ceruminous gland origin in the external auditory canal--a histopathological and immunohistochemical study].
  • OBJECTIVES: We present a case of a combined tumor consisting of solid tubular gland adenoma (TA) and syringocystadenoma papilliferum (SCAP) of the external auditory canal and review of the literature on this subject.
  • METHODS: Tumour of the external auditory canal was removed by retroauricular approach with good clinical outcome.
  • CONCLUSIONS: Tubular gland adenoma and syringocystadenoma papilliferum are benign tumors originating from ceruminous glands of the skin, characterized by very rare occurrence especially in the skin of the external auditory canal.
  • Every tumor arising from the external auditory canal should be examined histologically and immunohistochemically in order to choose the best treatment option.
  • [MeSH-minor] Biomarkers, Tumor. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 21302507.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Gheriani H, Tewary R, O'Sullivan TJ: Amyloidosis of the external auditory canal and middle ear: unusual ear tumor. Ear Nose Throat J; 2007 Feb;86(2):92-3, 106
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amyloidosis of the external auditory canal and middle ear: unusual ear tumor.
  • We describe the case of a 41-year-old man who had localized amyloidosis that involved the external auditory canal and middle ear.
  • To the best of our knowledge, only 4 other cases of amyloidosis involving the external auditory canal have been previously reported; in none of these cases was the middle ear involved.

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  • (PMID = 17385616.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Lenarz M, Durisin M, Kamenetzki P, Becker H, Kreipe HH, Lenarz T: Cavernous hemangioma of the internal auditory canal. Eur Arch Otorhinolaryngol; 2007 May;264(5):569-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cavernous hemangioma of the internal auditory canal.
  • Hemangiomas rarely occur in the internal auditory canal.
  • The presence of a small contrast-enhancing tumor in the internal auditory canal accompanied by severe sensorineural hearing loss and facial nerve palsy, should raise the suspicion of a hemangioma.
  • Due to their relative small size, the temporal bone CT-scan may show no evidence of pathological widening of the internal auditory canal or the typical intralesional calcifications at the time of presentation.
  • In this paper we report about a 51-year-old male presented with right-sided sensory-neural deafness and facial nerve palsy, accompanied by severe tinnitus and ipsilateral loss of vestibular function due to a cavernous hemangioma in the internal auditory canal.

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  • (PMID = 17235534.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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20. Bhandare N, Mendenhall WM, Antonelli PJ: Radiation effects on the auditory and vestibular systems. Otolaryngol Clin North Am; 2009 Aug;42(4):623-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation effects on the auditory and vestibular systems.
  • Because of the variability of tumor location and dimensions, sparing of nontarget normal tissue and organs may not be possible.
  • Treatment modalities that deliver the highest doses of radiation to the auditory system include stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) for the treatment of vestibular schwannomas (VS), and fractionated radiotherapy (FRT) or intensity-modulated radiation therapy (IMRT) for the treatment of head and neck malignancies.
  • Radiation therapy for VS is unique because of its involvement of the inner ear and preexisting auditory and vestibular dysfunction.
  • Auditory and vestibular dysfunction following RT for VS may be limited by limiting the total dose of cranial nerve VIII irradiation and by fractionation.

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  • (PMID = 19751868.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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21. Park HJ, Kim HJ, Bae GS, Seo SW, Kim DY, Jung WS, Kim MS, Song MY, Kim EK, Kwon KB, Hwang SY, Song HJ, Park CS, Park RK, Chong MS, Park SJ: Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells. Hear Res; 2009 Nov;257(1-2):53-62
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells.
  • However, the role of GSK-3 in the auditory system remains unknown.
  • Here we examined whether the GSK-3-specific inhibitors, SB 216763 and LiCl, could protect against cisplatin-induced cytotoxicity of auditory cells.
  • Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in cisplatin-injected mice.
  • Furthermore, administration of SB 216763 or LiCl reduced the thresholds of the auditory brainstem response (ABR) in cisplatin-injected mice.
  • [MeSH-minor] Acoustic Stimulation. Animals. Apoptosis / drug effects. Caspases / metabolism. Cell Line. Disease Models, Animal. Dose-Response Relationship, Drug. Enzyme Activation. Evoked Potentials, Auditory, Brain Stem / drug effects. Hair Cells, Auditory / drug effects. Hair Cells, Auditory / enzymology. Injections, Intraperitoneal. Interleukin-1beta / blood. Interleukin-6 / blood. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Organ Culture Techniques. Phosphorylation. Rats. Rats, Sprague-Dawley. Time Factors. Tumor Necrosis Factor-alpha / blood

  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. LITHIUM CHLORIDE .
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  • (PMID = 19666099.001).
  • [ISSN] 1878-5891
  • [Journal-full-title] Hearing research
  • [ISO-abbreviation] Hear. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Interleukin-1beta; 0 / Interleukin-6; 0 / Maleimides; 0 / Protein Kinase Inhibitors; 0 / SB 216763; 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3; EC 3.4.22.- / Caspases; G4962QA067 / Lithium Chloride; Q20Q21Q62J / Cisplatin
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22. Fayad JN, Otto SR, Brackmann DE: Auditory brainstem implants: surgical aspects. Adv Otorhinolaryngol; 2006;64:144-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory brainstem implants: surgical aspects.
  • Patients with neurofibromatosis type 2 often develop bilateral life-threatening vestibular schwannoma necessitating tumor removal, which results in deafness.
  • We developed the auditory brainstem implant (ABI) in order to be able to electrically stimulate the cochlear nucleus complex in patients with bilateral cochlear nerve injury from bilateral schwannoma.
  • After tumor removal, the electrode array of the ABI is inserted into the lateral recess of the fourth ventricle and placed over the surface of the ventral and dorsal cochlear nuclei.
  • The ABI is designed to stimulate auditory neural structures within the cochlear nucleus in order to convey salient cues about the frequency, amplitude, and temporal characteristics of sounds.
  • [MeSH-major] Auditory Brain Stem Implants. Cochlear Nucleus / surgery. Hearing Loss / surgery

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  • (PMID = 16891840.001).
  • [ISSN] 0065-3071
  • [Journal-full-title] Advances in oto-rhino-laryngology
  • [ISO-abbreviation] Adv. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 16
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23. Bouccara D, Kalamarides M, Bozorg Grayeli A, Ambert-Dahan E, Rey A, Sterkers O: [Auditory brainstem implant: indications and results]. Ann Otolaryngol Chir Cervicofac; 2007 Jul;124(3):148-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Auditory brainstem implant: indications and results].
  • OBJECTIVES: To summarize the indications and evaluate the Auditory Brainstem Implant (ABI) performances in neurofibromatosis type 2 (NF2) and other otologics indications, as postmeningitis ossified cochlea.
  • The auditory perception with the ABI is evaluated by testing, the words recognition in open-set lists, and the speech understanding with usual sentences.
  • RESULTS: In NF2 patients, best results are obtained in cases of smaller vestibular schwannoma and none, or short term, auditory deprivation.
  • Negative prognostic factors are duration of total hearing loss (>10 years), tumor size (>30 mm), difficulties in electrode array placement, complications during post-operative course and number of active electrodes (<10).
  • CONCLUSION: These results show a clear benefit of ABI in NF2 patients, with or without previous tumor removal, in case of small tumor with a short duration of hearing loss.
  • [MeSH-major] Auditory Brain Stem Implants. Hearing Loss, Sensorineural / surgery

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  • (PMID = 17320034.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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24. Tywończuk-Szulc M, Kibiłda B: [Malignant melanoma of the auditory tube]. Otolaryngol Pol; 2007;61(3):335-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant melanoma of the auditory tube].
  • The most common site of the tumor are the nasal and paranasal sinuses but melanomas of the oral cavity are described too.
  • The nasopharyngoscopy revealed a bluish red, friable and granulomatous tumor occupying the whole pharyngeal orifice of the left auditory tube.

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  • (PMID = 17847794.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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25. Nakamura M, Roser F, Dormiani M, Samii M, Matthies C: Intraoperative auditory brainstem responses in patients with cerebellopontine angle meningiomas involving the inner auditory canal: analysis of the predictive value of the responses. J Neurosurg; 2005 Apr;102(4):637-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative auditory brainstem responses in patients with cerebellopontine angle meningiomas involving the inner auditory canal: analysis of the predictive value of the responses.
  • OBJECT: Meningiomas of the cerebellopontine angle (CPA) can either arise from or secondarily grow into the inner auditory canal (IAC).
  • The aim of this retrospective study was to investigate the reliability and predictive importance of auditory brainstem responses (ABRs) for the determination of postoperative auditory function in patients with CPA meningiomas in comparison with results obtained in patients who undergo surgery for vestibular schwannomas.
  • On analysis, ABR monitoring demonstrated stable findings in 24 patients throughout tumor resection and fluctuating signals in 10 patients.
  • CONCLUSIONS: The presence and absence of ABRs during surgery for CPA meningiomas reliably predicted the presence and absence of postoperative auditory function.
  • [MeSH-minor] Adult. Aged. Cerebellopontine Angle. Ear, Inner / pathology. Ear, Inner / physiology. Evoked Potentials, Auditory. Female. Humans. Intraoperative Period. Male. Middle Aged. Neuroma, Acoustic / complications. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 15871505.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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26. Kazikdas KC, Onal K, Kuehnel TS, Ozturk T: An intradermal nevus of the external auditory meatus. Eur Arch Otorhinolaryngol; 2006 Mar;263(3):253-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An intradermal nevus of the external auditory meatus.
  • We herein describe a rare case of an intradermal nevus arising in the external auditory meatus.
  • Upon excisional biopsy, the tumor was diagnosed as an intradermal nevus.

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  • (PMID = 16012861.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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27. Dazert S, Aletsee C, Brors D, Mlynski R, Sudhoff H, Hildmann H, Helms J: Rare tumors of the internal auditory canal. Eur Arch Otorhinolaryngol; 2005 Jul;262(7):550-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rare tumors of the internal auditory canal.
  • The study was performed to identify the incidence and histology of rare tumors with growth restricted to the internal auditory canal (IAC) that are different from vestibular schwannoma (VS).
  • Cases with a tumor entity other than VS were analyzed for symptoms, radiological diagnosis, intraoperative findings and postoperative histolopatology to determine if a differential diagnosis to the common VS can be established prior to surgery.
  • An analysis of the operation reports revealed that in 10 out of the 15 cases the surgeon suspected an unusual tumor of the IAC during surgery.
  • Intraoperative findings such as adhesion to cranial nerves and consistency of the tumor often indicate unusual processes, but histological analysis of the removed tissue is essential for the definite diagnosis.

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  • (PMID = 15947938.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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28. Samii M, Nakamura M, Mirzai S, Vorkapic P, Cervio A: Cavernous angiomas within the internal auditory canal. J Neurosurg; 2006 Oct;105(4):581-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cavernous angiomas within the internal auditory canal.
  • OBJECT: The aim of this study was to describe the symptomatology, radiological features, and surgical treatment of patients with cavernous angiomas within the internal auditory canal (IAC).
  • Four patients also reported facial symptoms such as hemispasm or progressive palsy; one of these patients had presented with sudden facial paresis due to intrameatal tumor hemorrhage.
  • The cochlear nerve could not be functionally preserved because of its extreme adherence to the tumor, although its continuity was preserved in four patients.

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  • (PMID = 17044562.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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29. Dinh CT, Haake S, Chen S, Hoang K, Nong E, Eshraghi AA, Balkany TJ, Van De Water TR: Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes. Neuroscience; 2008 Nov 19;157(2):405-13
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes.
  • OBJECTIVE: Determine the molecular mechanism(s) behind tumor necrosis factor-alpha (TNFalpha)-induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to protect against TNFalpha ototoxicity.
  • [MeSH-major] Apoptosis / drug effects. Dexamethasone / pharmacology. Gene Expression / drug effects. Glucocorticoids / pharmacology. Hair Cells, Auditory / drug effects. Organ of Corti / cytology
  • [MeSH-minor] Analysis of Variance. Animals. Animals, Newborn. Organ Culture Techniques. Proto-Oncogene Proteins c-bcl-2 / genetics. Proto-Oncogene Proteins c-bcl-2 / metabolism. Rats. Rats, Sprague-Dawley. Receptors, Tumor Necrosis Factor, Type I / genetics. Receptors, Tumor Necrosis Factor, Type I / metabolism. Time Factors. Tumor Necrosis Factor-alpha / toxicity. bcl-2-Associated X Protein / genetics. bcl-2-Associated X Protein / metabolism. bcl-X Protein / genetics. bcl-X Protein / metabolism

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  • Hazardous Substances Data Bank. DEXAMETHASONE .
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  • (PMID = 18838114.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Receptors, Tumor Necrosis Factor, Type I; 0 / Tumor Necrosis Factor-alpha; 0 / bcl-2-Associated X Protein; 0 / bcl-X Protein; 7S5I7G3JQL / Dexamethasone
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30. Yaşar H, Ozkul H, Somay A: A rare vascular tumor of the external auditory canal: the capillary hemangioma. Kulak Burun Bogaz Ihtis Derg; 2009 Jul-Aug;19(4):212-5
Genetic Alliance. consumer health - Hemangioma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare vascular tumor of the external auditory canal: the capillary hemangioma.
  • A computed tomography scan of the temporal bone showed 0.6 x 0.8 cm diameter soft-tissue mass arising from the right external auditory canal, 0.5 cm away from tympanic membrane.
  • Hemangioma of the external auditory canal is a rare otologic entity.
  • According to the literature, this case represents the second patient with capillary hemangioma of the external auditory canal.

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  • (PMID = 19860637.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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31. Karagama YG, Bridges LR, van Hille PT: Angioleiomyoma of the internal auditory meatus: a rare occurrence in the internal auditory canal. Ear Nose Throat J; 2005 Apr;84(4):216, 218

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angioleiomyoma of the internal auditory meatus: a rare occurrence in the internal auditory canal.
  • We describe a case of angioleiomyoma of the internal auditory meatus.
  • A finding of this tumor at this site is very unusual.
  • In our patient, the tumor was clinically and radiologically difficult to distinguish from an acoustic neuroma.
  • It would be important to recognize this rare small tumor preoperatively because it may be appropriate to manage it conservatively.

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  • (PMID = 15929320.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Lenarz T, Lim HH, Reuter G, Patrick JF, Lenarz M: The auditory midbrain implant: a new auditory prosthesis for neural deafness-concept and device description. Otol Neurotol; 2006 Sep;27(6):838-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The auditory midbrain implant: a new auditory prosthesis for neural deafness-concept and device description.
  • The auditory midbrain implant (AMI) is a new central auditory prosthesis designed for penetrating stimulation of the human inferior colliculus.
  • Because of the absence of a viable auditory nerve, these patients cannot benefit from cochlear implants.
  • An alternative solution has been the auditory brainstem implant (ABI), which stimulates the cochlear nucleus.
  • The fact that the ABI is able to produce high levels of speech perception in nontumor patients (with inaccessible cochleae or posttraumatic damage to the cochlear nerve) suggests that limitations in ABI performance in NF2 patients may be associated with cochlear nucleus damage caused by the tumors or the tumor removal process.
  • Thus, stimulation of the auditory midbrain proximal to the damaged cochlear nucleus may be a better alternative for hearing restoration in NF2 patients.
  • The goal of this article is to present the ICC as an alternative site for an auditory implant for NF2 patients and to describe the design of the first human prototype AMI.
  • [MeSH-minor] Algorithms. Auditory Brain Stem Implants. Humans. Neurofibromatosis 2 / complications. Neuroma, Acoustic / complications. Neuroma, Acoustic / etiology. Neuroma, Acoustic / surgery. Treatment Outcome

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  • (PMID = 16936570.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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33. Kiyomizu K, Matsuda K, Nakayama M, Tono T, Matsuura K, Kawano H, Toyama K, Komune S: Preservation of the auditory nerve function after translabyrinthine removal of vestibular schwannoma. Auris Nasus Larynx; 2006 Mar;33(1):7-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preservation of the auditory nerve function after translabyrinthine removal of vestibular schwannoma.
  • OBJECTIVE: To evaluate the function of the postoperative auditory nerve preserved after translabyrinthine (TL) vestibular schwannoma (VS) removal.
  • METHODS: Fifteen patients, who underwent unilateral VS resection via a TL approach, were preserved auditory nerve anatomically.
  • After surgery, the electrical stimulation test (EST) or electrically evoked auditory brainstem response (EABR) was performed.
  • RESULTS: Four cases (27%) out of fifteen patients were retained the functional integrity of the auditory nerve after surgery.
  • The maximum tumor size in the group with a positive response to EST or EABR was significantly smaller than that in the group with a negative response to EST.
  • It seems to be difficult to preserve auditory nerve function in cases where a tumor extends to the fundus of internal auditory canal.
  • CONCLUSION: These results suggest that size of tumor and/or extension of tumor to the fundus might be important factors in preserving the auditory nerve function even if using a TL approach.
  • [MeSH-minor] Adult. Aged. Electric Stimulation. Evoked Potentials, Auditory, Brain Stem. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Period. Preoperative Care

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  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
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  • (PMID = 16310997.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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34. Tanigawa T, Inafuku S, Nakayama M: Five cases of chondroma involving the external auditory canal. Auris Nasus Larynx; 2008 Dec;35(4):559-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Five cases of chondroma involving the external auditory canal.
  • A cartilaginous tumor located in the external auditory canal is a rare finding.
  • Only 48 cases of chondromas of the external auditory canal have been documented in the literature.
  • We have encountered five cases of external auditory canal chondroma.
  • Otoscopic examination demonstrated a tiny firm tumor protruding from the anterior wall of the bony external auditory canal.
  • Surgery was performed all cases, and the tumor proved to be a chondroma histologically.
  • From our experiences, it is important to recognize that chondromas are in the differential of small exophytic tumors on the anterior or superior wall of the external auditory canal and can be removed safely and effectively through the transcanal approach.

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  • (PMID = 18242908.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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35. Xiao H, Au DK, Hui Y, Chow CK, Fan YW, Wei WI: [Auditory brainstem implantation in patient with bilateral acoustic neuromas]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Nov;19(22):1017-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Auditory brainstem implantation in patient with bilateral acoustic neuromas].
  • OBJECTIVE: To restore auditory sensation for patient suffering loss of hearing due to bilateral acoustic neuromas.
  • METHOD: One patient of bilateral acoustic neuromas received auditory brainstem implant (ABI) at the same surgery for resection of the second tumor.
  • The retrosigmoid approach was used for resection of the tumor and to exposure the lateral recess of the fourth ventricle for placement of ABI electrode array.
  • Intraoperative 7th and 9th nerves monitoring and electrically evoked auditory brainstem responses (EABR) were recorded to localize the placement of ABI electrode array.
  • Auditory sensation was perceived on stimulation of all channels.
  • CONCLUSION: The multichannel ABI could effectively restore auditory sensation for patient deafened by bilateral acoustic neuromas.
  • [MeSH-major] Auditory Brain Stem Implantation. Deafness / rehabilitation. Neurofibromatosis 2 / surgery
  • [MeSH-minor] Auditory Brain Stem Implants. Humans. Male. Middle Aged

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  • (PMID = 16463763.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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36. Du Q, Wang Z: [Six cases of adenoid cystic carcinoma in external auditory canal]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Feb;20(4):158-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Six cases of adenoid cystic carcinoma in external auditory canal].
  • OBJECTIVE: By investigating the clinical and pathological features of adenoid cystic carcinoma in external auditory canal, we can improve our ability of diagnosis and treatment.
  • METHOD: A retrospective analysis was performed on 6 patients with adenoid cystic carcinoma in external auditory canal, including clinical manifestations, the therapy as well as the follow-up results.
  • CONCLUSION: Adenoid cystic carcinoma in external auditory canal grows slowly, so patients can live with the tumor for a long time.

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  • (PMID = 16711439.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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37. Mashkevich G, Undavia S, Iacob C, Arigo J, Linstrom C: Malignant cylindroma of the external auditory canal. Otol Neurotol; 2006 Jan;27(1):97-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant cylindroma of the external auditory canal.
  • OBJECTIVE: This report describes a case of a malignant cylindroma arising in the external auditory canal.
  • CONCLUSION: To our knowledge, this is the first report describing a malignant degeneration of cylindroma in the external auditory canal.
  • This tumor represents an extremely rare cutaneous neoplasm, thus raising diagnostic and therapeutic challenges.

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  • (PMID = 16371854.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Crestani S, Vellin JF, Nohra O, Gabrillargues J, Kemeny JL, Gilain L, Mom T: [Adenoid cystic carcinoma of the external auditory canal]. Ann Otolaryngol Chir Cervicofac; 2007 Dec;124(6):314-7
Genetic Alliance. consumer health - Adenoid Cystic Carcinoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenoid cystic carcinoma of the external auditory canal].
  • OBJECTIVES: To report a case of adenoid cystic carcinoma of the external auditory canal with petrous involvement.
  • Computed tomography and biopsy revealed an adenoid cystic carcinoma of the external auditory canal.
  • Adenoid cystic carcinoma of the external auditory canal is a rare tumor.
  • The most important survival factor is removal of the tumor with histologically free margins.
  • The adenoid cystic carcinoma is a rare neoplasm of the external auditory canal.

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  • (PMID = 17521599.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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39. Kanzaki S, Ito M, Takada Y, Ogawa K, Matsuo K: Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin. Bone; 2006 Aug;39(2):414-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin.
  • We asked whether auditory ossicles are resorbed in Opg(-/-) mice, and whether these mice suffer from impaired auditory function.
  • These data suggest that osteoprotegerin plays a crucial role in hearing by protecting the auditory ossicles and otic capsule from osteoclastic bone resorption.
  • [MeSH-major] Bone Resorption / pathology. Ear Ossicles / pathology. Glycoproteins / genetics. Hearing Loss / genetics. Hearing Loss / physiopathology. Receptors, Cytoplasmic and Nuclear / genetics. Receptors, Tumor Necrosis Factor / genetics
  • [MeSH-minor] Acoustic Stimulation. Animals. Evoked Potentials, Auditory, Brain Stem / genetics. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Heterozygote. Mice. Mice, Inbred C57BL. Mice, Knockout. Osteoprotegerin. Time Factors

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  • (PMID = 16564235.001).
  • [ISSN] 8756-3282
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / Osteoprotegerin; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, Tumor Necrosis Factor; 0 / Tnfrsf11b protein, mouse
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40. Pepper JP, McKeever P, Gebarski S, Spector M, Thompson BG, Arts HA: Angioleiomyoma of the internal auditory canal: clinical and radiographic features. Otol Neurotol; 2010 Dec;31(9):1451-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angioleiomyoma of the internal auditory canal: clinical and radiographic features.
  • OBJECTIVE: Discussion of a rare case of angioleiomyoma of the internal auditory canal.
  • CONCLUSION: Angioleiomyoma is a rare lesion of the internal auditory canal that has many similar clinical and radiographic features of a vestibular schwannoma.
  • There are no previous reports of this tumor occurring within the internal auditory canal in this age group.

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  • (PMID = 20838354.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antiviral Agents; HG18B9YRS7 / Valine; MZ1IW7Q79D / valacyclovir; VB0R961HZT / Prednisone; X4HES1O11F / Acyclovir
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46. Yasumatsu R, Okura K, Sakiyama Y, Nakamuta M, Matsumura T, Uehara S, Yamamoto T, Komune S: Metastatic hepatocellular carcinoma of the external auditory canal. World J Gastroenterol; 2007 Dec 21;13(47):6436-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic hepatocellular carcinoma of the external auditory canal.
  • This report describes a rare case of metastatic hepatocellular carcinoma (HCC) presenting a huge mass in the left external auditory canal (EAC).
  • Histopathologic examination indicated that the tumor was secondary to HCC.
  • Although external irradiation was not effective, the tumor was treated with surgical debulking and high dose rate 192 Ir remote afterloading system (RALS) for postoperative intracavitary irradiation.

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  • (PMID = 18081236.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Iridium Radioisotopes
  • [Number-of-references] 10
  • [Other-IDs] NLM/ PMC4205466
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47. Sun JQ, Han DM, Li YX, Gong SS, Zan HR, Wang T: Combined endoscope-assisted translabyrinthine subtemporal keyhole approach for vestibular Schwannoma and auditory midbrain implantation: Cadaveric study. Acta Otolaryngol; 2010 Oct;130(10):1125-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined endoscope-assisted translabyrinthine subtemporal keyhole approach for vestibular Schwannoma and auditory midbrain implantation: Cadaveric study.
  • CONCLUSIONS: The combined endoscope-assisted translabyrinthine subtemporal keyhole approach can expose the internal auditory canal, cerebellopontine, and inferior colliculus satisfactorily in the same surgical setting.
  • As a minimally invasive approach, this can be considered an effective method for removal of vestibular schwannoma and auditory midbrain implantation in the same surgical setting, while avoiding retraction of the cerebellum and serious adverse events and complications.
  • OBJECTIVES: Patients with neurofibromatosis type II are the initial candidates for auditory midbrain implantation; the appropriate surgical approach should allow for tumor removal and electrode implantation in the same surgical setting.
  • RESULTS: With the help of an endoscope, we exposed the internal auditory canal and cerebellopontine through a translabyrinthine approach and the inferior colliculus through a subtemporal keyhole approach.
  • This double approach can be combined to expose the internal auditory canal and cerebellopontine and inferior colliculus satisfactorily in the same surgical setting.

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  • (PMID = 20367538.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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48. Dong F, Gidley PW, Ho T, Luna MA, Ginsberg LE, Sturgis EM: Adenoid cystic carcinoma of the external auditory canal. Laryngoscope; 2008 Sep;118(9):1591-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma of the external auditory canal.
  • OBJECTIVE/HYPOTHESIS: To describe the clinical history and outcome of patients with adenoid cystic carcinoma (ACC) of the external auditory canal (EAC).
  • METHODS: A search of our institution's tumor registry identified 22 patients with ACC of the EAC.

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  • (PMID = 18677277.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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49. Lin CH, Chen TJ, Chen SS: Functional changes on ascending auditory pathway in rats caused by germanium dioxide exposure: an electrophysiological study. Toxicology; 2009 Feb 4;256(1-2):110-7
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  • [Title] Functional changes on ascending auditory pathway in rats caused by germanium dioxide exposure: an electrophysiological study.
  • Because of its anti-tumor and immunomodulative effects, Ge-containing compounds are also used as health-promoting ingredients in food.
  • Even now, the effect of germanium on auditory system function is not completely clear.
  • To clarify this question, brainstem auditory evoked potentials (BAEPs) were applied to examine the effect of germanium dioxide (GeO(2)) on the ascending auditory pathway.
  • These results suggest the toxic effect of GeO(2) on the conduction of the auditory system, and that inhibitory effect of GeO(2) on the voltage-gated sodium channels might play a role in GeO(2)-induced abnormal hearing loss.
  • [MeSH-major] Auditory Pathways / physiology. Germanium / toxicity. Sodium Channel Blockers. Sodium Channels / drug effects
  • [MeSH-minor] Animals. Body Weight / drug effects. Cell Line, Tumor. Dose-Response Relationship, Drug. Electrophysiology. Evoked Potentials, Auditory, Brain Stem / drug effects. Ion Channel Gating / drug effects. Male. Mice. Neurons / drug effects. Patch-Clamp Techniques. Rats. Rats, Wistar

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  • (PMID = 19059453.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Sodium Channel Blockers; 0 / Sodium Channels; 00072J7XWS / Germanium; 5O6CM4W76A / germanium oxide
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50. Bae SJ, Shimizu K, Yozaki M, Yamaoka T, Akiyama Y, Yoshizaki A, Muroi E, Hara T, Ogawa F, Sato S: Involvement of L-selectin in contact hypersensitivity responses augmented by auditory stress. Am J Pathol; 2010 Jan;176(1):187-97
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  • [Title] Involvement of L-selectin in contact hypersensitivity responses augmented by auditory stress.
  • Auditory stress augmented CH responses in the present study.
  • Namely, ear thickness and mast cell numbers were significantly increased in stressed CH mice. mRNA expression of preprotachykinin-A, a precursor of substance-P; interferon-gamma; interleukin (IL)-4; IL-6; and tumor necrosis factor-alpha significantly increased in stressed CH mice.
  • Meanwhile, treatment with anti-L-selectin Ab resulted in a significant decrease in ear thickness and mRNA levels of interferon-gamma, IL-4, IL-6, and tumor necrosis factor-alpha, but failed to significantly reduce preprotachykinin-A mRNA levels and mast cell numbers.
  • Our results indicated that auditory stress enhances CH response and that the augmentation of this CH response might be mediated through L-selectin, but not through P- or E-selectin pathways.

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  • (PMID = 19948832.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Cytokines; 0 / E-Selectin; 0 / Neurokinin-1 Receptor Antagonists; 0 / P-Selectin; 0 / RNA, Messenger; 126880-86-2 / L-Selectin
  • [Other-IDs] NLM/ PMC2797881
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51. Gerganov VM, Samii A, Paterno V, Stan AC, Samii M: Bilateral osteomas arising from the internal auditory canal: case report. Neurosurgery; 2008 Feb;62(2):E528-9; discussion E529
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral osteomas arising from the internal auditory canal: case report.
  • OBJECTIVE: Osteomas arising from the internal auditory canal and developing in the cerebellopontine angle have rarely been reported.
  • Brain magnetic resonance imaging and computed tomographic scans displayed bilateral cerebellopontine angle osteomas arising from the internal auditory canal.
  • The larger tumor on the left side was found to be compressing the vestibulocochlear nerve.
  • INTERVENTION: Surgery was performed on the symptomatic side via the retrosigmoid approach, and the tumor was removed completely.

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  • (PMID = 18382293.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Schrock A, Laffers W, Bootz F: Solitary metastasis of lung carcinoma to the internal auditory canal. Am J Otolaryngol; 2006 May-Jun;27(3):214-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary metastasis of lung carcinoma to the internal auditory canal.
  • We report a case of solitary metastasis of lung carcinoma into the internal auditory canal.
  • Magnetic resonance imaging revealed an intracanalicular tumor, which was interpreted as vestibular schwannoma.
  • After tumor resection, the histopathologic examination revealed a metastasis of a squamous cell carcinoma.

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  • (PMID = 16647989.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Huang Q, Wu H, Xiang M, Wang Z, Wang Z: [Cavernous hemangioma in internal auditory canal: case report and review of the literature]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Oct;20(19):873-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cavernous hemangioma in internal auditory canal: case report and review of the literature].
  • OBJECTIVE: To discuss the diagnosis and treatment of cavernous hemangioma in internal auditory canal (IAC).
  • RESULT: The tumor was totally removed by translabyrinthine approach without any complication, such as facial paralysis or cerebrospinal fluid otorrhea.

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  • (PMID = 17168111.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
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54. Ushio M, Iwasaki S, Chihara Y, Kawahara N, Morita A, Saito N, Murofushi T: Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response? Acta Otolaryngol; 2009 Oct;129(10):1095-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response?
  • CONCLUSIONS: The results of the caloric test, vestibular evoked myogenic potential (VEMP), and auditory brainstem response (ABR) in patients with vestibular schwannoma (VS) did not show clear correlation with the nerve origin of the tumor but with tumor size.
  • When we focused on patients with VS within the internal acoustic canal (IAC), neither the nerve origin of the tumor nor the tumor size showed clear correlation with the results of these tests.
  • Tumor size was measured with preoperative MRI.
  • RESULTS: The nerve origin of the tumor was identified in 63 of the 109 patients.
  • Mean tumor size in patients showing abnormal responses was larger than that in patients showing normal responses on each test.
  • [MeSH-minor] Adult. Aged. Caloric Tests. Evoked Potentials, Auditory, Brain Stem. Humans. Middle Aged. Vestibular Evoked Myogenic Potentials. Vestibular Nerve / pathology. Vestibular Nerve / physiopathology. Young Adult

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  • (PMID = 19034733.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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55. Ogawa S, Tawara I, Ueno S, Kimura M, Miyazaki K, Nishikawa H, Yamaguchi M, Kobayashi T, Shiku H: De novo CD5-positive diffuse large B-cell lymphoma of the temporal bone presenting with an external auditory canal tumor. Intern Med; 2006;45(11):733-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] De novo CD5-positive diffuse large B-cell lymphoma of the temporal bone presenting with an external auditory canal tumor.
  • The patient was admitted because of a mass in the left external auditory canal.

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  • (PMID = 16819255.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD5; 3Z8479ZZ5X / Epirubicin; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CEOP protocol 1
  • [Number-of-references] 33
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61. Haake SM, Dinh CT, Chen S, Eshraghi AA, Van De Water TR: Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling. Hear Res; 2009 Sep;255(1-2):22-32
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  • [Title] Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K/Akt and NFkappaB signaling.
  • BACKGROUND: Tumor necrosis factor alpha (TNFalpha) is associated with trauma-induced hearing loss.
  • HYPOTHESIS: Dexamethasone (Dex) protects auditory hair cells (AHCs) from trauma-induced loss by activating cellular signal pathways that promote cell survival.
  • [MeSH-major] Apoptosis / drug effects. Dexamethasone / pharmacology. Hair Cells, Auditory / cytology. Hair Cells, Auditory / drug effects. NF-kappa B / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Tumor Necrosis Factor-alpha / pharmacology

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  • (PMID = 19442713.001).
  • [ISSN] 1878-5891
  • [Journal-full-title] Hearing research
  • [ISO-abbreviation] Hear. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Benzyl Compounds; 0 / Boc-D-FMK; 0 / Caspase Inhibitors; 0 / Hydrocarbons, Fluorinated; 0 / NF-kappa B; 0 / Receptors, Glucocorticoid; 0 / Tumor Necrosis Factor-alpha; 7S5I7G3JQL / Dexamethasone; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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62. James ML, Husain AM: Brainstem auditory evoked potential monitoring: when is change in wave V significant? Neurology; 2005 Nov 22;65(10):1551-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brainstem auditory evoked potential monitoring: when is change in wave V significant?
  • BACKGROUND: The probability of hearing loss during cerebellopontine angle (CPA) surgery can be reduced by using brainstem auditory evoked potential (BAEP) intraoperative monitoring (IOM).
  • When patients with CPA tumor were excluded, a significantly higher number of patients in Group 4 had hearing loss.
  • Analysis of the patients with CPA tumor showed no difference in the frequency of hearing loss in any of the groups; even a large number (50%) of Group 1 patients had hearing impairment.
  • CONCLUSIONS: During brainstem auditory evoked potential intraoperative monitoring, the type of surgery is important when interpreting significance of changes of wave V.
  • For non-cerebellopontine angle tumor surgery, hearing loss occurs usually only with permanent loss of wave V; much smaller changes may be important in cerebellopontine angle tumor surgery.
  • [MeSH-major] Cochlear Nerve / physiopathology. Evoked Potentials, Auditory, Brain Stem / physiology. Hearing Loss, Sensorineural / diagnosis. Monitoring, Intraoperative / methods. Neurosurgical Procedures / adverse effects. Postoperative Complications / diagnosis
  • [MeSH-minor] Acoustic Stimulation. Auditory Pathways / physiopathology. Brain Stem / pathology. Brain Stem / physiopathology. Brain Stem / surgery. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / surgery. Female. Humans. Iatrogenic Disease / prevention & control. Male. Neural Conduction / physiology. Predictive Value of Tests. Reaction Time / physiology. Retrospective Studies

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  • [CommentIn] Neurology. 2005 Nov 22;65(10):1522-3 [16301476.001]
  • (PMID = 16301480.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Holley M, Tokuda M: Role of phosphatase and tensin homolog in the development of the mammalian auditory system. Neuroreport; 2010 Jul 14;21(10):731-5
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  • [Title] Role of phosphatase and tensin homolog in the development of the mammalian auditory system.
  • Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene that controls neural stem cell renewal and differentiation and is a potential target for regeneration in the optic nerve.
  • Here we show that it has a critical pattern of expression in the mammalian developing auditory system.
  • [MeSH-major] Cochlea / growth & development. Ganglia, Sensory / growth & development. Hair Cells, Auditory / metabolism. PTEN Phosphohydrolase / metabolism. Sensory Receptor Cells / metabolism. Spiral Ganglion / growth & development
  • [MeSH-minor] Animals. Auditory Pathways / embryology. Auditory Pathways / growth & development. Auditory Pathways / metabolism. Epithelium / embryology. Epithelium / growth & development. Epithelium / metabolism. Mice. Mice, Inbred ICR

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  • (PMID = 20531234.001).
  • [ISSN] 1473-558X
  • [Journal-full-title] Neuroreport
  • [ISO-abbreviation] Neuroreport
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
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64. Lan MY, Shiao JY: Using greater superficial petrosal nerve and geniculate ganglion as the only two landmarks for identifying internal auditory canal in middle fossa approach. Eur Arch Otorhinolaryngol; 2010 Dec;267(12):1867-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Using greater superficial petrosal nerve and geniculate ganglion as the only two landmarks for identifying internal auditory canal in middle fossa approach.
  • The middle fossa approach is a surgical technique indicated for acoustic neuroma with advantages of complete tumor removal and hearing preservation.
  • Various methods have been developed for identifying internal auditory canal (IAC).

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  • (PMID = 20614126.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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65. Tringali S, Ferber-Viart C, Fuchsmann C, Buiret G, Zaouche S, Dubreuil C: Hearing preservation in retrosigmoid approach of small vestibular schwannomas: prognostic value of the degree of internal auditory canal filling. Otol Neurotol; 2010 Dec;31(9):1469-72
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  • [Title] Hearing preservation in retrosigmoid approach of small vestibular schwannomas: prognostic value of the degree of internal auditory canal filling.
  • OBJECTIVES: To assess the contribution of preoperative radiologic appearance of vestibular schwannoma (VS) on the magnetic resonance imaging in constructive interference in steady-state sequences and demonstrate if the degree of the internal auditory canal (IAC) filling is correlated with hearing and facial preservation.
  • In case of patient with small tumor and IAC empty or filled less than 75% and with free fundus, surgery is the treatment of choice for patients with serviceable hearing and the desire to retain it.

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  • (PMID = 21113987.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Ahmed MK, Ishino T, Hirakawa K, Arihiro K: Syringoid eccrine carcinoma of external auditory canal. A case report. Auris Nasus Larynx; 2010 Aug;37(4):519-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Syringoid eccrine carcinoma of external auditory canal. A case report.
  • First described in 1969, syringoid eccrine carcinoma (SEC) is a rare cutaneous tumor with some controversy regarding its correct definition.
  • It behaves as locally aggressive tumor but metastases are rare.
  • Although there have been some previous reports describing clinical presentation and management of SEC in the skin, there has been no previous reports describing clinical findings and management of this tumor in the external auditory canal.
  • We report a case of a 57-year-old female with small solitary mass in left external auditory canal associated with discharge, severe itching and bleeding on manipulation.
  • Complete local excision is the recommended method for diagnosis and treatment of this tumor in the external auditory canal.
  • This extremely rare case serves as a springboard for the diagnosis as well as the management of SEC in external auditory canal.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Scalp / pathology. Scalp / surgery

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20172670.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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67. Colletti V, Shannon R, Carner M, Veronese S, Colletti L: Outcomes in nontumor adults fitted with the auditory brainstem implant: 10 years' experience. Otol Neurotol; 2009 Aug;30(5):614-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes in nontumor adults fitted with the auditory brainstem implant: 10 years' experience.
  • These outcomes require that we reevaluate the criteria for patient selection and the rationale for expanding the application for the auditory brainstem implant (ABI) to NT adult patients with profound hearing loss.
  • MATERIALS AND METHODS: In our Department, from April 1997 to September 2007, ABIs have been implanted in 112 patients (83 adults and 29 children) with tumor (T) and NT disorders.
  • [MeSH-major] Auditory Brain Stem Implantation. Hearing Loss / surgery

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  • (PMID = 19546832.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Khaimook W, Hirunpat S, Dejsukum C: Meningioma of the internal auditory canal: a case report. J Med Assoc Thai; 2005 Nov;88(11):1707-11
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  • [Title] Meningioma of the internal auditory canal: a case report.
  • Meningioma of the internal auditory canal is very rare.
  • The authors add a case report of a patient with meningioma of the internal auditory canal.
  • An MRI of the temporal bone demonstrated a tiny isointense intracanalicular tumor with inhomogeneous enhancement.
  • In the operative field carried out by translabyrinthine approach, the tumor was found in the IAC without intracranial involvement.

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  • (PMID = 16471123.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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69. Fleiner F, Jumah M, Göktas O: Cancer of the external auditory canal-diagnostic and treatment. Indian J Otolaryngol Head Neck Surg; 2009 Dec;61(4):270-4
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  • [Title] Cancer of the external auditory canal-diagnostic and treatment.
  • BACKGROUND: Ear squamous cell carcinoma (SCC) is a tumor with a poor prognosis, due to a late initial diagnosis because of a concealment by primarily benign symptoms and due to the unfavorable localization including the infiltration of important structures such as the middle ear, mandibular joint or dura.
  • PATIENTS AND METHODS: We retrospectively examined 10 patients, medium age: 63.8 ± 9.3 years between 2002 and 2008 with a histological confirmed SCC of the external auditory canal.

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  • (PMID = 23120649.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450079
  • [Keywords] NOTNLM ; Carcinoma of the external auditory canal / Prognosis / Radiation treatment / Squamous cell carcinoma / Surgery
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70. Yeh SY, Chao TK: Leiomyoma of the external auditory canal--a case report and brief review of the literature. Eur Arch Otorhinolaryngol; 2005 May;262(5):397-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyoma of the external auditory canal--a case report and brief review of the literature.
  • It is extremely rare that leiomyoma appears in the external auditory canal.
  • A 47-year-old male with left external auditory canal leiomyoma presented with conductive hearing impairment and post-auricular swelling.
  • Tumor excision was successful via a retroauricular approach.
  • To date, including our case, only three cases of external auditory canal leiomyoma have been reported.
  • The tumor occurs mainly in adult males aged around 50 and should be included in the differential diagnoses for external auditory canal tumor.
  • In case of an external auditory canal tumor, even if it is believed to be benign before surgery, precise pathologic examination is required to exclude the possibility of malignancy.

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  • (PMID = 15368068.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 8
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71. Edwards E, Soltani M, Kim W, Dalal SS, Nagarajan SS, Berger MS, Knight RT: Comparison of time-frequency responses and the event-related potential to auditory speech stimuli in human cortex. J Neurophysiol; 2009 Jul;102(1):377-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of time-frequency responses and the event-related potential to auditory speech stimuli in human cortex.
  • We recorded the electrocorticogram directly from the exposed cortical surface of awake neurosurgical patients during the presentation of auditory syllable stimuli.
  • All patients were unanesthetized as part of a language-mapping procedure for subsequent left-hemisphere tumor resection.

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  • (PMID = 19439673.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC006435; United States / NIDCD NIH HHS / DC / DC004855-07; United States / NIDCD NIH HHS / DC / DC-006435; United States / NINDS NIH HHS / NS / NS-21135; United States / NINDS NIH HHS / NS / 1F32-NS-061616-01; United States / NIDCD NIH HHS / DC / R01 DC004855-07; United States / NIDCD NIH HHS / DC / DC-4855; United States / NIDCD NIH HHS / DC / R01 DC006435-05; United States / NIDCD NIH HHS / DC / R01 DC004855
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2712274
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72. Vincenti V, Pasanisi E, Guida M, Di Trapani G, Sanna M: Hearing rehabilitation in neurofibromatosis type 2 patients: cochlear versus auditory brainstem implantation. Audiol Neurootol; 2008;13(4):273-80
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  • [Title] Hearing rehabilitation in neurofibromatosis type 2 patients: cochlear versus auditory brainstem implantation.
  • OBJECTIVE: We aimed to evaluate and compare the auditory performance of neurofibromatosis type 2 (NF2) patients with bilateral total deafness fitted with cochlear or auditory brainstem implants.
  • Nine patients suffering from NF2 who underwent hearing rehabilitation by means of cochlear (4 patients) or auditory brainstem (5 patients) implantation participated in the study.
  • Postoperative auditory performance was assessed using closed- and open-set tests.
  • Among the 5 patients who underwent auditory brainstem implantation, 1 reached good open-set speech recognition skills, scoring 70% in the common phrases comprehension test, and she was able to communicate on the telephone.
  • In this small cohort, cochlear implant patients performed better than auditory brainstem implant patients, even if variability in auditory performance was observed with both devices.
  • More studies are needed in order to clarify the role and reliability of electrophysiological tests in predicting the residual functionality of the cochlear nerve after tumor removal.
  • [MeSH-major] Auditory Brain Stem Implants. Cochlear Implantation / methods. Deafness / rehabilitation. Neurofibromatosis 2 / rehabilitation. Neuroma, Acoustic / rehabilitation. Speech Reception Threshold Test


73. Muñoz Herrera A, Coscarón Blanco E, Beltrán Mateos LD, Paniagua Escudero J, Morales Ramos F: [Auditory-evoked brainstem response in a schwannoma of the VIIIth cranial nerve: an anatomophysiological and functional correlation. Our experience]. Acta Otorrinolaringol Esp; 2005 Apr;56(4):147-51
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  • [Title] [Auditory-evoked brainstem response in a schwannoma of the VIIIth cranial nerve: an anatomophysiological and functional correlation. Our experience].
  • They expande eccentrically from the nerve promoting a disturbance in the neural function either due to vascular compresion or to the effect of the tumor itself on the nerve, disturbance that can be evidenced with the Auditory-evoked Brainstem Response (ABR), fact that constituted the base for their diagnosis in the past.
  • Whose diagnosis was done between 1997 and 2003 in relation to the size of the tumour and the residual auditory function.
  • ABR patterns do not relate to the size of the tumour but they do to the auditory function.
  • [MeSH-major] Cranial Nerve Neoplasms / physiopathology. Evoked Potentials, Auditory, Brain Stem. Neurilemmoma / physiopathology

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  • (PMID = 15871289.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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74. Topal O, Erbek SS, Erbek S: Schwannoma of the external auditory canal: a case report. Head Face Med; 2007;3:6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannoma of the external auditory canal: a case report.
  • BACKGROUND: Schwannomas are uncommon benign tumors of the external auditory canal.
  • CASE PRESENTATION: A 51-year-old patient presented with a mass obliterating the external auditory meatus.
  • CONCLUSION: Schwannoma, rarely seen in the external auditory canal, can be managed by a precise excision of the tumor via transmeatal approach.

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  • (PMID = 17224070.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1797166
  • [General-notes] NLM/ Original DateCompleted: 20070808
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75. So H, Kim H, Lee JH, Park C, Kim Y, Kim E, Kim JK, Yun KJ, Lee KM, Lee HY, Moon SK, Lim DJ, Park R: Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB. J Assoc Res Otolaryngol; 2007 Sep;8(3):338-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB.
  • Both neutralization of proinflammatory cytokines and pharmacologic inhibition of ERK significantly attenuated the death of HEI-OC1 auditory cells caused by cisplatin and proinflammatory cytokines.
  • [MeSH-minor] Animals. Antioxidants / pharmacology. Cell Line. Female. Guinea Pigs. Interleukin-1beta / metabolism. Interleukin-6 / metabolism. MAP Kinase Kinase 1 / metabolism. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17516123.001).
  • [ISSN] 1525-3961
  • [Journal-full-title] Journal of the Association for Research in Otolaryngology : JARO
  • [ISO-abbreviation] J. Assoc. Res. Otolaryngol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC005025
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antioxidants; 0 / Cytokines; 0 / Interleukin-1beta; 0 / Interleukin-6; 0 / NF-kappa B; 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.12.2 / MAP Kinase Kinase 1; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ PMC2538433
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76. Trellakis S, Benzenberg D, Urban BW, Friederich P: Differential lidocaine sensitivity of human voltage-gated potassium channels relevant to the auditory system. Otol Neurotol; 2006 Jan;27(1):117-23
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  • [Title] Differential lidocaine sensitivity of human voltage-gated potassium channels relevant to the auditory system.
  • BACKGROUND: Recent molecular evidence suggests that the voltage-gated potassium channels Kv 3.1 and Kv 1.1 play an important functional role in the auditory system.
  • Lidocaine is known to influence the auditory system and may thus exert pharmacological effects on these human potassium channels.
  • The small effect at clinically relevant concentrations suggests that the physiologic roles of Kv 3.1 and Kv 1.1 channels in auditory neurons seem not to be impaired during the therapeutic or diagnostic application of lidocaine in the auditory system.
  • [MeSH-minor] Cell Culture Techniques. Cell Line. Hearing Loss / etiology. Hearing Loss / physiopathology. Humans. Patch-Clamp Techniques. Tumor Cells, Cultured

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  • (PMID = 16371858.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Local; 0 / Potassium Channel Blockers; 0 / Potassium Channels, Voltage-Gated; 98PI200987 / Lidocaine
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77. Gouveris H, Mann W: Association between surgical steps and intraoperative auditory brainstem response and electrocochleography waveforms during hearing preservation vestibular schwannoma surgery. Eur Arch Otorhinolaryngol; 2009 Feb;266(2):225-9
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  • [Title] Association between surgical steps and intraoperative auditory brainstem response and electrocochleography waveforms during hearing preservation vestibular schwannoma surgery.
  • Intraoperative monitoring of the auditory pathway by means of either electrocochleography or auditory brainstem response audiometry is valuable during hearing preservation vestibular schwannoma (VS) surgery.
  • A more than 75% intraoperative reduction of the amplitude of these evoked auditory potentials was thought to be related with clear hearing compromise of hearing.
  • Most frequently, drilling of the internal auditory canal and direct tumor resection were associated with the aforementioned changes, but also drilling of the cortical temporal bone at the very beginning of surgery or the opening of the dura could be implicated.
  • [MeSH-major] Audiometry, Evoked Response / methods. Evoked Potentials, Auditory, Brain Stem. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 18553092.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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78. Tran Ba Huy P, Kania R, Frachet B, Poncet C, Legac MS: Auditory rehabilitation with cochlear implantation in patients with neurofibromatosis type 2. Acta Otolaryngol; 2009 Sep;129(9):971-5
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  • [Title] Auditory rehabilitation with cochlear implantation in patients with neurofibromatosis type 2.
  • CONCLUSIONS: New technological developments will most probably improve the efficiency of auditory brainstem implantation (ABI).
  • Auditory results are far better than those reported after ABI.
  • OBJECTIVES: ABIs restore some degree of auditory perception in NF2 patients with bilateral and complete hearing loss, but results are often inadequate for maintaining social and professional activities.
  • The aim of this study was to report the results of auditory rehabilitation by cochlear implantation in three cases of NF2.
  • Imaging follow-ups at 4, 2, and 1 year, respectively, do not show any evolution of the tumor.

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  • (PMID = 19016361.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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79. Gharabaghi A, Koerbel A, Samii A, Kaminsky J, von Goesseln H, Tatagiba M, Samii M: The impact of hypotension due to the trigeminocardiac reflex on auditory function in vestibular schwannoma surgery. J Neurosurg; 2006 Mar;104(3):369-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The impact of hypotension due to the trigeminocardiac reflex on auditory function in vestibular schwannoma surgery.
  • The authors studied the impact of this reflex on postoperative auditory function in patients undergoing vestibular schwannoma (VS) surgery.
  • METHODS: One hundred patients scheduled for VS surgery were studied prospectively for parameters influencing the postoperative auditory function.
  • The evaluation included sex, age, pre- and postoperative auditory function, preoperative mean arterial blood pressure, preoperative medical diseases or medication (for example, antiarrhythmia drugs), tumor size and localization, and the intraoperative occurrence of the TCR.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Auditory Perception. Female. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Reflex, Abnormal. Treatment Outcome

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  • [CommentIn] J Neurosurg. 2007 Jul;107(1):243; author reply 243-4 [17639902.001]
  • (PMID = 16572648.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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80. Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U: p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neurosci; 2007 Feb 7;27(6):1434-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis.
  • Sensory hair cells of the auditory organ are generated during embryogenesis and remain postmitotic throughout life.
  • The codeletion of p19(Ink4d) and p21(Cip1) triggered profuse S-phase entry of auditory hair cells during a restricted period in early postnatal life, leading to the transient appearance of supernumerary hair cells.
  • These data, together with the demonstration of changing expression patterns of multiple CKIs in auditory hair cells during the stages of early postnatal maturation, show that the maintenance of the postmitotic state is an active, tissue-specific process, cooperatively regulated by several CKIs, and is critical for the lifelong survival of these sensory cells.

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  • (PMID = 17287518.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01 DC007173; United States / NCI NIH HHS / CA / CA-71907; United States / NCI NIH HHS / CA / CA-90832; United States / NIDCD NIH HHS / DC / DC-007173
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn1a protein, mouse; 0 / Cdkn2d protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p19; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53
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81. Tsukahara K, Suzuki M, Tokashiki R, Motohashi R, Iwaya K: Pleomorphic adenoma of the external auditory canal complicated by hearing loss secondary to chronic otitis media. Auris Nasus Larynx; 2006 Jun;33(2):183-6
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  • [Title] Pleomorphic adenoma of the external auditory canal complicated by hearing loss secondary to chronic otitis media.
  • Pleomorphic adenoma (PA) rarely occurs in the external auditory canal (EAC).
  • At the initial examination, a tumor covered by smooth skin was seen filling the left EAC.
  • The CT and MRI findings led to a diagnosis of a tumor of the left EAC complicated with an inflammatory middle-ear lesion.
  • The tumor was excised en bloc with the overlying skin, and tympanoplasty was performed.

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  • (PMID = 16309867.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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82. Grayeli AB, Kalamarides M, Bouccara D, Ambert-Dahan E, Sterkers O: Auditory brainstem implant in neurofibromatosis type 2 and non-neurofibromatosis type 2 patients. Otol Neurotol; 2008 Dec;29(8):1140-6
MedlinePlus Health Information. consumer health - Hearing Aids.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory brainstem implant in neurofibromatosis type 2 and non-neurofibromatosis type 2 patients.
  • OBJECTIVE: To evaluate the auditory brainstem implant (ABI) performances in neurofibromatosis type 2 (NF2) and non-NF2 patients.
  • INTERVENTION: Auditory brainstem implant was placed through a translabyrinthine or a retrosigmoid approach.
  • MAIN OUTCOME MEASURES: Auditory brainstem implant was evaluated by open-set words and sentences in sound, vision, and sound-plus-vision modes.
  • CONCLUSION: A clear benefit of ABI could be evidenced in NF2 patients, especially in case of small tumor and short duration of hearing loss.
  • Auditory brainstem implant may also be indicated in patients with bilateral profound hearing loss and a predictable failure of cochlear implantation.
  • [MeSH-major] Auditory Brain Stem Implantation / methods. Hearing Aids. Neurofibromatosis 2 / surgery. Prosthesis Implantation / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Cochlea / pathology. Cohort Studies. Ear, Inner / abnormalities. Electric Stimulation. Evoked Potentials, Auditory / physiology. Humans. Meningitis / complications. Middle Aged. Neuroma, Acoustic / surgery. Ossification, Heterotopic / etiology. Otosclerosis / complications. Retrospective Studies. Young Adult

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  • (PMID = 18849886.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Samii A, Lenarz M, Majdani O, Lim HH, Samii M, Lenarz T: Auditory midbrain implant: a combined approach for vestibular schwannoma surgery and device implantation. Otol Neurotol; 2007 Jan;28(1):31-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory midbrain implant: a combined approach for vestibular schwannoma surgery and device implantation.
  • The goal of this study was to assess if this approach can be extended to a lateral supracerebellar infratentorial approach to enable insertion of an auditory midbrain implant (AMI) penetrating array along the tonotopic gradient of the inferior colliculus central nucleus (ICC).
  • BACKGROUND: The AMI is a new auditory prosthesis designed for penetrating stimulation of the ICC in patients with neural deafness.
  • RESULTS: The lateral suboccipital craniotomy enabled sufficient exposure of the cerebellopontine angle and internal auditory canal for tumor removal.
  • [MeSH-major] Auditory Brain Stem Implants. Deafness / etiology. Deafness / surgery. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 17195743.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Jeong HJ, Kim SJ, Moon PD, Kim NH, Kim JS, Park RK, Kim MS, Park BR, Jeong S, Um JY, Kim HM, Hong SH: Antiapoptotic mechanism of cannabinoid receptor 2 agonist on cisplatin-induced apoptosis in the HEI-OC1 auditory cell line. J Neurosci Res; 2007 Mar;85(4):896-905
Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antiapoptotic mechanism of cannabinoid receptor 2 agonist on cisplatin-induced apoptosis in the HEI-OC1 auditory cell line.
  • CB2 mRNA was constitutively expressed in the auditory cell line HEI-OC1.
  • Finally, JWH-015 inhibited cisplatin-induced reactive oxygen species and tumor necrosis factor-alpha production.
  • [MeSH-major] Apoptosis / drug effects. Cisplatin / pharmacology. Hair Cells, Auditory, Outer / drug effects. Indoles / pharmacology. Receptor, Cannabinoid, CB2 / agonists
  • [MeSH-minor] Analysis of Variance. Animals. Caspases / metabolism. Cell Count / methods. Cell Cycle / drug effects. Cell Line. Cytochromes c / metabolism. DNA Fragmentation / drug effects. Dose-Response Relationship, Drug. Drug Interactions. Mice. Organ of Corti / cytology. RNA, Messenger / metabolism. Reactive Oxygen Species / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17183590.001).
  • [ISSN] 0360-4012
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indoles; 0 / JHW 015; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0 / Receptor, Cannabinoid, CB2; 0 / Tumor Necrosis Factor-alpha; 9007-43-6 / Cytochromes c; EC 3.4.22.- / Caspases; Q20Q21Q62J / Cisplatin
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85. Ozluoglu LN, Yilmaz I, Cagici CA, Bal N, Erdogan B: Ganglioneuroma of the internal auditory canal: a case report. Audiol Neurootol; 2007;12(3):160-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ganglioneuroma of the internal auditory canal: a case report.
  • Ganglioneuroma is a rare, benign, slow-growing tumor thought to develop from cells of neural crest origin, even though hypotheses on the pathogenesis of that lesion differ.
  • Magnetic resonance imaging revealed a mass (3 x 4 mm) in the internal auditory canal (IAC).
  • The encapsulated tumor was entirely excised via the middle fossa approach.

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  • [Copyright] Copyright 2007 S. Karger AG, Basel.
  • (PMID = 17259702.001).
  • [ISSN] 1421-9700
  • [Journal-full-title] Audiology & neuro-otology
  • [ISO-abbreviation] Audiol. Neurootol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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86. Ban JH, Lee JK, Jin SM, Lee KC: Basaloid squamous cell carcinoma of the external auditory canal: case report. Eur Arch Otorhinolaryngol; 2007 Jun;264(6):697-9
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  • [Title] Basaloid squamous cell carcinoma of the external auditory canal: case report.
  • The tumor has a predilection for the upper aerodigestive tract, and has been suggested to behave more aggressively than squamous cell carcinoma (SCC).
  • To the author's knowledge, BSCC confined to the external auditory canal (EAC) has not been previously described.
  • Excision of the tumor was accomplished by modified lateral temporal bone resection.

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  • (PMID = 17235532.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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87. Kokkonen SM, Kiviniemi V, Mäkiranta M, Yrjänä S, Koivukangas J, Tervonen O: Effect of brain surgery on auditory and motor cortex activation: a preliminary functional magnetic resonance imaging study. Neurosurgery; 2005 Aug;57(2):249-56; discussion 249-56
Hazardous Substances Data Bank. OXYGEN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of brain surgery on auditory and motor cortex activation: a preliminary functional magnetic resonance imaging study.
  • The aim of this preliminary study was to observe the effect of tumor resection on BOLD fMRI of the auditory and motor cortices.
  • The auditory and motor cortices were localized with activation studies.
  • RESULTS: The resection of a glioma with preoperative edema resulted in an increase from the preoperative to the early postoperative fMRI on auditory BOLD activation on the side of the tumor compared with the contralateral side.
  • However, when no preoperative edema was present, a transient decrease in relative auditory BOLD activation was found.
  • CONCLUSION: The results of this study suggest that the resection of a glioma with preoperative edema affecting the auditory and/or motor cortex may cause a transient increase in the BOLD response ipsilateral to the tumor.
  • It seems that when the tumor is resected, the pressure on the brain, specifically on the affected auditory and/or motor cortex, decreases and the functional cortex becomes more easily detectable in BOLD fMRI.
  • [MeSH-major] Auditory Cortex / blood supply. Brain Neoplasms / surgery. Glioma / surgery. Magnetic Resonance Imaging. Motor Cortex / blood supply. Neurosurgical Procedures / methods

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  • (PMID = 16094153.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] S88TT14065 / Oxygen
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88. Van De Water TR, Abi Hachem RN, Dinh CT, Bas E, Haake SM, Hoosien G, Vivero R, Chan S, He J, Eshraghi AA, Angeli SI, Telischi FF, Balkany TJ: Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms. Cochlear Implants Int; 2010 Jun;11 Suppl 1:42-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms.
  • RESULTS: in vivo: local DXM treatment of EIT-animals prevents trauma-induced loss of ABR thresholds that occurs in EIT-animals and EIT-animals treated with the carrier solution (i.e., AP), and prevented loss of auditory hair cells.
  • [MeSH-major] Dexamethasone / pharmacology. GTPase-Activating Proteins / metabolism. Hair Cells, Auditory / drug effects. Hearing Loss / prevention & control. Tumor Necrosis Factor-alpha / adverse effects
  • [MeSH-minor] Animals. Apoptosis / drug effects. Apoptosis / genetics. Auditory Threshold / drug effects. Cells, Cultured. Disease Models, Animal. Down-Regulation. Electrodes, Implanted / adverse effects. Gene Expression Regulation. Guinea Pigs. In Vitro Techniques. Organ of Corti / drug effects. Random Allocation. Real-Time Polymerase Chain Reaction. Reference Values. Up-Regulation. Wounds and Injuries / complications

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  • (PMID = 21756583.001).
  • [ISSN] 1754-7628
  • [Journal-full-title] Cochlear implants international
  • [ISO-abbreviation] Cochlear Implants Int
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ABR protein, human; 0 / GTPase-Activating Proteins; 0 / Tumor Necrosis Factor-alpha; 7S5I7G3JQL / Dexamethasone
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89. Utsuki S, Oka H, Miyajima Y, Shimizu S, Suzuki S, Fujii K: Auditory alert system for fluorescence-guided resection of gliomas. Neurol Med Chir (Tokyo); 2008 Feb;48(2):95-7; discussion 97-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory alert system for fluorescence-guided resection of gliomas.
  • Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection using 5-aminolevulinic acid labeling is one of the most valuable tools available to determine the extent of glioma infiltration, but requires repeated spectroscopic evaluation of the tissue.
  • The present method informs the surgeon of residual tumor in real time using spectrum analysis of PPIX fluorescence and an audible alert system.
  • The target region was illuminated with a laser with a peak wavelength of 405 +/- 1 nm in addition to the usual microscope halogen lamp during tumor resection.
  • The surgeon can detect tumor infiltration far more objectively and with less effort using this system during tumor resection.

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  • (PMID = 18296881.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Protoporphyrins; 553-12-8 / protoporphyrin IX
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90. Chang KH, Song CE, Seo JH, Yeo SW: Solitary metastasis of bronchogenic adenocarcinoma to the internal auditory canal: a case report. J Korean Med Sci; 2009 Dec;24(6):1227-9
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  • [Title] Solitary metastasis of bronchogenic adenocarcinoma to the internal auditory canal: a case report.
  • We report a patient with an isolated metastasis to the internal auditory canal (IAC) of bronchogenic adenocarcinoma.
  • The patient underwent a translabyrinthine removal of the tumor.

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  • [Cites] Arch Otolaryngol Head Neck Surg. 2000 Feb;126(2):209-14 [10680873.001]
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  • (PMID = 19949690.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2775882
  • [Keywords] NOTNLM ; Adenocarcinoma / Internal Auditory Canal / Lung Neoplasms / Neoplasm Metastasis
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91. Miller RS, Pensak ML: An anatomic and radiologic evaluation of access to the lateral internal auditory canal via the retrosigmoid approach and description of an internal labyrinthectomy. Otol Neurotol; 2006 Aug;27(5):697-704

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An anatomic and radiologic evaluation of access to the lateral internal auditory canal via the retrosigmoid approach and description of an internal labyrinthectomy.
  • OBJECTIVE: The retrosigmoid approach to the posterior petrous bone may be used as a hearing preservation operation for extirpation of posterior fossa and internal auditory canal (IAC) lesions.
  • However, it is usually not possible to remove tumor from the most lateral portions of the IAC even after removing the retrolabyrinthine bone down to the posterior semicircular canal.
  • [MeSH-minor] Cadaver. Evoked Potentials, Auditory, Brain Stem. Female. Humans. Male. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16868518.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Chun H, Clymer B, Sammet S, Koch RM, Stevens R, Knopp MV: Improvement in the reproducibility of region of interest using an auditory feedback loop: a pilot assessment using dynamic contrast-enhanced (DCE) breast MR images. J Magn Reson Imaging; 2008 Jan;27(1):27-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improvement in the reproducibility of region of interest using an auditory feedback loop: a pilot assessment using dynamic contrast-enhanced (DCE) breast MR images.
  • PURPOSE: To augment traditional visual data perception of complex multiparametric imaging data sets by adding auditory feedback to improve the delineation of regions of interest (ROIs) in tumor assessment in dynamic contrast-enhanced (DCE) MRI.
  • MATERIALS AND METHODS: In addition to conventional display methodologies, we have created an application window which interfaces with audio output using dynamically loadable sound modules, providing goodness of fit (GF) information through auditory feedback.
  • The assessment was based on either conventional visual only mode or combined visual plus auditory mode.
  • RESULTS: Adding auditory feedback improves repeatability significantly (P < 0.01), and the enhanced sensory approach had higher repeatability than visual only mode in visually complex breast tumor cases.
  • CONCLUSION: Adding auditory information to visual based image analysis for identifying tumor ROIs provides higher interobserver repeatability for analyzing complex multidimensional/multiparametric medical image data sets with visually difficult lesions to delineate.
  • [MeSH-major] Auditory Perception. Breast Neoplasms / pathology. Magnetic Resonance Imaging / methods

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  • (PMID = 18058928.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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93. Piccirillo E, Guida M, Flanagan S, Lauda L, Fois P, Sanna M: CNAP To Predict Functional Cochlear Nerve Preservation in NF-2: Cochlear Implant or Auditory Brainstem Implant. Skull Base; 2008 Jul;18(4):281-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CNAP To Predict Functional Cochlear Nerve Preservation in NF-2: Cochlear Implant or Auditory Brainstem Implant.
  • The ideal management of bilateral vestibular schwannomas (VSs) involves complete tumor resection with preservation of hearing in at least one ear.
  • While auditory brainstem implants (ABIs) have represented a significant advance in the management of neurofibromatosis type 2 (NF-2) patients, hearing rehabilitation is far from ideal.
  • More recently, cochlear implantation has been used in selected cases of NF-2, following tumor removal, where the patient is left with bilateral profound hearing loss but with anatomical continuity of the cochlear nerve.
  • Thirty-nine tumors have been removed, with 10 patients having had bilateral tumor removed.
  • In the setting of a negative fast auditory brainstem response (ABR), but preserved cochlear nerve action potential (CNAP), the option of a CI can be considered.
  • However, where the fast ABR and the morphology and amplitude of the CNAP are significantly degraded at the brainstem, the placement of an ABI should be strongly considered at the time of tumor removal.

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  • (PMID = 19119343.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2467484
  • [Keywords] NOTNLM ; CNAP / Intraoperative monitoring / NF-2 / fast ABR / hearing rehabilitation
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94. Lescanne E, François P, Bakhos D, Velut S, Robier A, Pollak A: Vestibular schwannoma: dissection of the tumor and arachnoidal duplication. Otol Neurotol; 2008 Oct;29(7):989-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma: dissection of the tumor and arachnoidal duplication.
  • INTRODUCTION: In vestibular schwannoma (VS) surgery, the arachnoidal duplication, based on an epiarachnoidal origin of the tumor, is reputedly induced by medial growth of tumor and helpful in atraumatic dissection.
  • An additional series of 27 TBs without any tumor within the internal auditory meatus were also included.
  • No connective tissue or protrusion of a psammoma body was observed between the nerves and the vs. High magnification failed to demonstrate any meningeal cleavage plane between the facial or cochlear nerve and the tumor.
  • The subarachnoid space was visible within the internal auditory meatus and extended from the porus to the fundus.
  • CONCLUSION: We were not able to identify any layer between tumor and the intrameatal contents and did not observe any conjunctive-tissue capsule surrounding the intrameatal VS, as an epiarachnoidal tumor origin would suggest.

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  • (PMID = 18667937.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Onal C, Ozçelik TB, Sonmez S, Yilmaz B: Radiation dose distribution in the external auditory canal with different prosthetic materials: a clinical report. J Prosthet Dent; 2010 Nov;104(5):288-92
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  • [Title] Radiation dose distribution in the external auditory canal with different prosthetic materials: a clinical report.
  • Radiotherapy (RT) is an essential component of cancer treatment and aims to deliver higher doses at target volumes and lower doses to surrounding organs to achieve higher tumor control with fewer side effects.
  • The external ear and external auditory canal have irregular surfaces, which may cause dose heterogeneity, primarily resulting in excessive doses in the normal tissues lining and adjacent to the ear canal.
  • The purpose of this clinical report is to describe the use of an acrylic resin and an elastomeric material to fill the air cavities of the external auditory canal and compare the dosimetric parameters.

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  • [Copyright] Copyright © 2010 The Editorial Council of the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20970534.001).
  • [ISSN] 1097-6841
  • [Journal-full-title] The Journal of prosthetic dentistry
  • [ISO-abbreviation] J Prosthet Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Elastomers; 9011-14-7 / Polymethyl Methacrylate
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96. Kim CW, Rho YS, Cho SJ, Lee CH, Bae WJ: A case of ceruminous adenocarcinoma of the external auditory canal presenting as an aural polyp. Am J Otolaryngol; 2008 May-Jun;29(3):205-8

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  • [Title] A case of ceruminous adenocarcinoma of the external auditory canal presenting as an aural polyp.
  • Ceruminous adenocarcinoma is a rare malignant tumor arising from the ceruminous gland of the external auditory canal ceruminous gland.
  • Usually it displays no specific clinical symptoms or signs, so most reported cases have involved an advanced tumor and the treatment results have been disappointing.
  • We were able to detect the tumor early, and en bloc resection was possible in the form of a partial temporal bone resection.

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  • (PMID = 18439958.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Naganawa S, Sugiura M, Kawamura M, Fukatsu H, Nakashima T, Maruyama K: Prompt contrast enhancement of cerebrospinal fluid space in the fundus of the internal auditory canal: observations in patients with meningeal diseases on 3D-FLAIR images at 3 Tesla. Magn Reson Med Sci; 2006 Oct;5(3):151-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prompt contrast enhancement of cerebrospinal fluid space in the fundus of the internal auditory canal: observations in patients with meningeal diseases on 3D-FLAIR images at 3 Tesla.
  • We speculated that meningeal pathologies might facilitate the permeability of cranial nerves at the fundus of the internal auditory canal (IAC), causing prompt enhancement after administration of Gd-DTPA.
  • Twenty patients (aged 22 to 79 years) were divided into 2 groups, a group with meningeal disease comprising 9 patients with meningeal abnormalities (6, tumor dissemination; 3, infection) and a control group of 11 patients with unilateral IAC pathology whose healthy sides were included as controls.

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  • (PMID = 17139141.001).
  • [ISSN] 1347-3182
  • [Journal-full-title] Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
  • [ISO-abbreviation] Magn Reson Med Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; 84F6U3J2R6 / gadodiamide; K2I13DR72L / Gadolinium DTPA
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98. Elsürer C, Senkal HA, Zayyan E, Yilmaz T, Kaya S: Bilateral external auditory canal squamous cell carcinoma: a case report. Eur Arch Otorhinolaryngol; 2007 Aug;264(8):941-5
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  • [Title] Bilateral external auditory canal squamous cell carcinoma: a case report.
  • Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is an extremely rare malignant tumor with a prevalance between 1 and 6 cases per 1 million population.

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  • (PMID = 17361413.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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99. Cristalli G, Manciocco V, Pichi B, Marucci L, Arcangeli G, Telera S, Spriano G: Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. J Craniofac Surg; 2009 May;20(3):816-21
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  • [Title] Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma.
  • No patients were found to have residual gross tumor.
  • Radical external auditory canal and/or middle ear canal resection is of utmost importance to obtain a good surgical outcome.

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  • (PMID = 19381105.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Okada T, Saito K, Takahashi M, Hasegawa Y, Fujimoto Y, Terada A, Kamei Y, Yoshida J: En bloc petrosectomy for malignant tumors involving the external auditory canal and middle ear: surgical methods and long-term outcome. J Neurosurg; 2008 Jan;108(1):97-104

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] En bloc petrosectomy for malignant tumors involving the external auditory canal and middle ear: surgical methods and long-term outcome.
  • OBJECTIVES: The aim of this study was to describe a method for resecting malignant tumors originating in the external auditory canal or middle ear and requiring en bloc resection of the petrous bone.
  • During a mean follow-up period of 45 months, 3 patients died of tumor recurrence.
  • Two of four patients with tumor extension into the inner ear died.

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  • (PMID = 18173317.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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