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1. Casagrande R, Georgetti SR, Verri WA, Jabor JR, Santos AC, Fonseca MJ: Evaluation of functional stability of quercetin as a raw material and in different topical formulations by its antilipoperoxidative activity. AAPS PharmSciTech; 2006 Mar;7(1):E64-E71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There was no detectable loss of activity during 182 days (6 months) of storage at all tested temperatures (4°C, room temperature [RT], 37°C, and 45°C) for the raw material.
  • In conclusion, the results suggest that the activity of quercetin depends on iron chelation, and its posible usefulness as a topical antioxidant to prevent oxidative stress-induced skin damage depends on maintaining its antilipoperoxidative activity stored at RT, which avoids special storage conditions.

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  • (PMID = 28290025.001).
  • [ISSN] 1530-9932
  • [Journal-full-title] AAPS PharmSciTech
  • [ISO-abbreviation] AAPS PharmSciTech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; antioxidant / flavonoids / lipid peroxidation / quercetin / stability
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2. Ho-Pun-Cheung A, Cellier D, Lopez-Crapez E: [Considerations for normalisation of RT-qPCR in oncology]. Ann Biol Clin (Paris); 2008 Mar-Apr;66(2):121-9
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  • [Title] [Considerations for normalisation of RT-qPCR in oncology].
  • [Transliterated title] La RT-qPCR en oncologie: considérations pour la normalisation.
  • In this context, the reverse transcription quantitative polymerase chain reaction (RT-qPCR) has become the "gold standard" for mRNA quantification.
  • Normalisation can be carried out against a housekeeping gene, total RNA mass, or cell number.
  • By reviewing the different methods available and their related problems, the aim of this article is to provide recommendations for the set up of an appropriate normalisation strategy for RT-qPCR data in oncology.
  • [MeSH-minor] Cell Count. DNA, Complementary / biosynthesis. Electrophoresis. Fluorescence. Gene Expression. Humans. Models, Genetic. RNA, Messenger / genetics. RNA, Neoplasm / genetics. RNA, Ribosomal / genetics. Reference Standards

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  • (PMID = 18390422.001).
  • [ISSN] 0003-3898
  • [Journal-full-title] Annales de biologie clinique
  • [ISO-abbreviation] Ann. Biol. Clin. (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / RNA, Ribosomal
  • [Number-of-references] 43
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3. Chiou SH, Kao CL, Chen YW, Chien CS, Hung SC, Lo JF, Chen YJ, Ku HH, Hsu MT, Wong TT: Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. PLoS One; 2008;3(5):e2090
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  • [Title] Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor.
  • Atypical teratoid/rhabdoid tumor (AT/RT) is an extremely malignant neoplasm in the central nervous system (CNS) which occurs in infancy and childhood.
  • Recent studies suggested that CD133 could be considered a marker for brain cancer stem-like cells (CSCs).
  • However, the role of CD133 in AT/RT has never been investigated.
  • Herein we report the isolation of CD133-positive cells (CD133(+)), found to have the potential to differentiate into three germ layer tissues, from tissues of nine AT/RT patients.
  • The clinical data showed that the amount of CD133(+) in AT/RTs correlated positively with the degree of resistance to radiation therapy.
  • In sum, this is the first report indicating that CD133(+) AT/RT cells demonstrate the characteristics of CSCs.
  • The IR-resistant and anti-apoptotic properties in CD133(+) may reflect the clinical refractory malignancy of AT/RTs and thus the activated p-ATM pathway and BCL-2 expression in CD133(+) could be possible targets to improve future treatment of deadly diseases like AT/RT.
  • [MeSH-major] Antigens, CD / immunology. Glycoproteins / immunology. Peptides / immunology. Radiation Tolerance. Rhabdoid Tumor / diagnosis

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  • (PMID = 18509505.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Glycoproteins; 0 / Peptides; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Small Interfering
  • [Other-IDs] NLM/ PMC2396792
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4. Jóźwiak J, Bikowska B, Grajkowska W, Sontowska I, Roszkowski M, Galus R: Activation of Akt/mTOR pathway in a patient with atypical teratoid/rhabdoid tumor. Folia Neuropathol; 2010;48(3):185-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activation of Akt/mTOR pathway in a patient with atypical teratoid/rhabdoid tumor.
  • A typical teratoid/rhabdoid tumor (AT/RT) is a highly malignant childhood brain tumor.
  • Most AT/RTs are shown to contain chromosome 22 mutation in the region of hSNF5/INI1 gene, whose protein product participates in chromatin remodeling.
  • Although the presence of this mutation is well described, molecular pathways underlying AT/RT development are poorly, if at all, understood.
  • In the current paper we evaluate a case of AT/RT with special consideration of two pathways often implicated in tumor development: protein kinase B (PKB or Akt) and extracellular signal-regulated kinase (Erk).
  • First, we confirmed expression of typical protein pattern being unique for AT/RT, including epithelial membrane antigen, S-100 and glial fibrillary acidic protein.
  • We found that Erk pathway signaling in the tumor was not upregulated.
  • At the same time, inhibitor of Akt pathway, phosphatase and tensin homolog (PTEN), was not upregulated.
  • These results strongly support the hypothesis that Akt pathway contributes to chromatin remodeling disruption, promoting malignant transformation of AT/RT.


5. Rades D, Stalpers LJ, Veninga T, Schulte R, Hoskin PJ, Alberti W: [Effectiveness and toxicity of reirradiation (Re-RT) for metastatic spinal cord compression (MSCC)]. Strahlenther Onkol; 2005 Sep;181(9):595-600

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  • [Title] [Effectiveness and toxicity of reirradiation (Re-RT) for metastatic spinal cord compression (MSCC)].
  • [Transliterated title] Effektivität und Toxizität einer Re-Bestrahlung (Re-RT) bei metastatisch bedingter Rückenmarkkompression (MBRK).
  • BACKGROUND AND PURPOSE: Radiation myelopathy is a serious late toxicity after radiotherapy (RT) of metastatic spinal cord compression (MSCC).
  • Many radiation oncologists are concerned about spinal Re-RT, because it may result in a high cumulative EQD2.
  • This study investigates effectiveness and feasibility of Re-RT for in-field recurrence of MSCC.
  • Primary RT was performed with 1 x 8 Gy (n = 34), 5 x 4 Gy (n = 28), 10 x 3 Gy (n = 4), 15 x 2.5 Gy (n = 4), or 20 x 2 Gy (n = 4).
  • Re-RT was performed with 1 x 8 Gy (n = 35), 5 x 3 Gy (n = 16), 5 x 4 Gy (n = 13), 10 x 2 Gy (n = 4), 12 x 2 Gy (n = 3), or 17 x 1.8 Gy (n = 3).
  • Follow-up after Re-RT was median 9 months (2-52 months).
  • RESULTS: Re-RT led to an improvement of motor function in 29/74 patients (39%; Figures 1 to 3).
  • On multivariate analysis, outcome was significantly influenced by type of primary tumor (p = 0.013) and by the time of developing motor deficits before Re-RT (p = 0.037), but not by radiation schedule (p = 0.560), by ambulatory status before Re-RT (p = 0.471), by cumulative EQD2 (p = 0.795), nor by the interval between primary RT and Re-RT (p = 0.420; Table 2).
  • CONCLUSION: Re-RT is an effective treatment for an in-field recurrence of MSCC.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cervical Vertebrae. Feasibility Studies. Female. Follow-Up Studies. Humans. Lumbar Vertebrae. Male. Middle Aged. Multivariate Analysis. Radiotherapy Dosage. Recovery of Function. Risk Factors. Thoracic Vertebrae. Time Factors. Treatment Outcome

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  • (PMID = 16170487.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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6. Honda M, Baba H, Yonekura M, Iseki M: Cerebral composite atypical teratoid/rhabdoid tumor and yolk sac tumor in the frontal lobe of an infant. Case report. Neurol Med Chir (Tokyo); 2005 Jun;45(6):318-21
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  • [Title] Cerebral composite atypical teratoid/rhabdoid tumor and yolk sac tumor in the frontal lobe of an infant. Case report.
  • A 1-year-old male infant presented with a rare cerebral composite tumor consisting of atypical teratoid/rhabdoid tumor (AT/RT) with epithelial and mesenchymal components and yolk sac tumor (YST) with Schiller-Duval bodies.
  • Computed tomography and magnetic resonance imaging revealed a large, intra-axial solid tumor with a cyst in the left frontal lobe.
  • Total resection of the tumor was performed.
  • Histological examination showed two different main growth patterns: solid sheets of undifferentiated polygonal cells and a few rhabdoid cells with rosette structures and rhabdomyoblastic cells; and reticular or papillary structures with occasional Schiller-Duval bodies in a myxoid matrix.
  • The immunohistochemical and electron microscopy findings indicated composite AT/RT and YST.
  • Initial total resection of the tumor was subsequently followed by local recurrence, hydrocephalus, and spinal metastasis.
  • AT/RT is a recently established entity of the central nervous system.
  • The present case of composite AT/RT and YST in the frontal lobe indicates the poor prognosis of such tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Frontal Lobe / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology

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  • (PMID = 15973067.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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7. Squire SE, Chan MD, Marcus KJ: Atypical teratoid/rhabdoid tumor: the controversy behind radiation therapy. J Neurooncol; 2007 Jan;81(1):97-111
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  • [Title] Atypical teratoid/rhabdoid tumor: the controversy behind radiation therapy.
  • To date, approximately 200 cases of atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system have been described in the literature.
  • This CNS tumor tends to present at an age of less than 3 years, and most patients succumb to their disease within 1 year of diagnosis.
  • Prior to the rise in utilization of immunohistochemical (IHC) testing in the late 1990s, this tumor was likely mistaken as medulloblastoma and treated as such.
  • However, lessons learned from regimens based upon medulloblastoma have revealed that AT/RT requires more aggressive treatment.
  • As most patients with AT/RT present as infants or young children, radiation therapy has been a less than standard treatment option.
  • A standardized and effective approach to treating this usually fatal tumor remains elusive, and the role of radiation therapy presents a particular dilemma as young patients with this disease may experience devastating late effects of therapy if they achieve a long-term survival.
  • Our review underscores the importance or enrolling patients in multi-institutional prospective studies to further investigate the value of radiation to treat this pediatric neoplasm.
  • [MeSH-major] Central Nervous System Neoplasms / radiotherapy. Radiotherapy / methods. Rhabdoid Tumor / radiotherapy. Teratoma / radiotherapy

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  • (PMID = 16855864.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 92
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8. Ammerlaan AC, Houben MP, Tijssen CC, Wesseling P, Hulsebos TJ: Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation. Childs Nerv Syst; 2008 Jul;24(7):855-7
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  • [Title] Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation.
  • OBJECTIVE: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy.
  • MATERIALS AND METHODS: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour.
  • CONCLUSION: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Meningioma / secondary. Mutation / genetics. Rhabdoid Tumor / genetics. Transcription Factors / genetics

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  • (PMID = 18236049.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2413122
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9. Fujisawa H, Misaki K, Takabatake Y, Hasegawa M, Yamashita J: Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 gene inactivation. J Neurooncol; 2005 Jun;73(2):117-24
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  • [Title] Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 gene inactivation.
  • OBJECT: Although atypical teratoid/rhabdoid tumor (AT/RT) is known to generate through inactivation of the hSNF5/INI1 gene on chromosome 22q, the downstream molecular mechanism remains unclear.
  • We histologically and molecularly reviewed our pediatric brain tumors for unrecognized AT/RTs and evaluated the role of cyclin D1, a potential molecular target of hSNF5/INI1.
  • METHODS: We analyzed 16 tumors under three years of age: seven medulloblastomas, three anaplastic ependymomas (E IIIs), two each of supratentorial primitive neuroectodermal tumors (sPNETs) and choroid plexus carcinomas (CPCs), and one each of neuroblastoma and pineoblastoma.
  • Because of the presence of rhabdoid cells and the polyimmunophenotypic features, the diagnosis was revised to AT/RT in five (31%) tumors, namely, two E IIIs and one each of medulloblastoma, CPC and pineoblastoma.
  • Cyclin D1 was overexpressed in those three tumors but not in the two that lacked hSNF5/INI1 inactivation.
  • CONCLUSION: AT/RT can be misdiagnosed as a variety of tumors, including ependymoma that potentially harbors LOH 22q.
  • Our data indicate that cyclin D1 is a target of hSNF5/INI1in primary tumors.
  • [MeSH-major] Central Nervous System Neoplasms / genetics. Chromosomes, Human, Pair 22 / genetics. Cyclin D1 / metabolism. DNA-Binding Proteins / genetics. Rhabdoid Tumor / genetics. Teratoma / genetics. Transcription Factors / genetics

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  • (PMID = 15981100.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors; 136601-57-5 / Cyclin D1
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10. Kao CL, Huang PI, Tsai PH, Tsai ML, Lo JF, Lee YY, Chen YJ, Chen YW, Chiou SH: Resveratrol-induced apoptosis and increased radiosensitivity in CD133-positive cells derived from atypical teratoid/rhabdoid tumor. Int J Radiat Oncol Biol Phys; 2009 May 1;74(1):219-28
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  • [Title] Resveratrol-induced apoptosis and increased radiosensitivity in CD133-positive cells derived from atypical teratoid/rhabdoid tumor.
  • PURPOSE: CD133 has recently been proposed as a marker for cancer stem-like cells (CSC) in brain tumors.
  • The aim of the present study was to investigate the possible role of resveratrol (RV) in radiosensitivity of CD133-positive/-negative cells derived from atypical teratoid/rhabdoid tumors (AT/RT-CD133(+/-)).
  • MATERIALS AND METHODS: AT/RT-CD133(+/-) were isolated and characterized by flow cytometry and quantitative real-time reverse transcription-polymerase chain reaction, and then treated with RV at different doses.
  • RESULTS: AT/RT-CD133(+) displayed enhanced self-renewal and highly coexpressed "stem cell" genes and drug-resistant genes, in addition to showing significant resistance to chemotherapeutic agents and radiotherapy as compared with CD133(-) cells.
  • After treatment with 200 microM RV, the in vitro proliferation rates and in vivo tumor restoration abilities of ATRT-CD133(+) were dramatically inhibited.
  • Importantly, treatment with 150 microM RV can effectively inhibit the expression of drug-resistant genes in AT/RT-CD133(+), and further facilitate to the differentiation of CD133(+) into CD133(-).
  • CONCLUSIONS: AT/RT-CD133(+) exhibit CSC properties and are refractory to IR treatment.
  • Our results suggest that RV treatment plays crucial roles in antiproliferative, proapoptotic, and radiosensitizing effects on treated-CD133(+/-); RV may therefore improve the clinical treatment of AT/RT.
  • [MeSH-major] Apoptosis / drug effects. Radiation Tolerance / drug effects. Radiation-Sensitizing Agents / therapeutic use. Rhabdoid Tumor / radiotherapy. Stilbenes / therapeutic use. Teratoma / radiotherapy
  • [MeSH-minor] Animals. Antigens, CD / analysis. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Cell Proliferation. Glycoproteins / analysis. Humans. Mice. Mice, Inbred BALB C. Mice, SCID. Peptides / analysis

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  • (PMID = 19362240.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Peptides; 0 / Radiation-Sensitizing Agents; 0 / Stilbenes; Q369O8926L / resveratrol
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11. Pérez S, Martínez ME, Labiano R, Gómez Peralta F, Salvador J: [Glucose sensors which provide real time information. Guardian RT/Paradigm RT]. Rev Enferm; 2009 Feb;32(2):50-1
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  • [Title] [Glucose sensors which provide real time information. Guardian RT/Paradigm RT].
  • [Transliterated title] Sensores de glucosa con información en tiempo real. Guardian RT/Paradigm RT.
  • In this report, the authors explain a specific program structured to insert and remove a glucose monitoring real time system called Guardian RT, plus the authors provide an explanation how to properly use the real time information which this monitoring system provides to patients and to the Diabetes Ward medical team respectively.

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  • (PMID = 19354153.001).
  • [ISSN] 0210-5020
  • [Journal-full-title] Revista de enfermería (Barcelona, Spain)
  • [ISO-abbreviation] Rev Enferm
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Blood Glucose
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12. Kao CL, Chiou SH, Ho DM, Chen YJ, Liu RS, Lo CW, Tsai FT, Lin CH, Ku HH, Yu SM, Wong TT: Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor. Am J Clin Pathol; 2005 Feb;123(2):297-304
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  • [Title] Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor.
  • Osteopontin, a cancer metastasis-associated gene, is specifically up-regulated in central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT), but its biological behavior in the progression of CNS AT/RT has never been studied.
  • We obtained plasma, cerebrospinal fluid (CSF), and brain tissue specimens from lobectomy or hemispherectomy samples from 39 patients (medulloblastoma, 16; AT/RT, 8; epilepsy, 6; hydrocephalus, 9).
  • By enzyme-linked immunosorbent assay, the median osteopontin levels in plasma and CSF in AT/RT (852.0 and 1,175.0 ng/mL, respectively) were significantly higher than in medulloblastoma (492.5 and 524.5 ng/mL, respectively) and hydrocephalus and epilepsy (208.0 and 168.0 ng/mL, respectively) (P < .05).
  • The results of real-time reverse transcriptase-polymerase chain reaction and immunohistochemical analysis demonstrated that osteopontin expression in AT/RT (n = 5) was significantly higher than in medulloblastoma (n = 8) samples.
  • The differences in osteopontin expression in plasma, CSF, and tumor samples in AT/RT and medulloblastoma correlated with survival differences.
  • In 5 patients with AT/RT, plasma osteopontin levels decreased after treatment but increased with relapse.
  • Osteopontin might be a potential marker to aid in identifying AT/RT recurrence.
  • [MeSH-major] Brain Neoplasms / metabolism. Rhabdoid Tumor / metabolism. Sialoglycoproteins. Teratoma / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Enzyme-Linked Immunosorbent Assay. Humans. Infant. Infant, Newborn. Medulloblastoma / metabolism. Medulloblastoma / mortality. Medulloblastoma / pathology. Neoplasm Recurrence, Local. Osteopontin. Survival Rate

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  • (PMID = 15842057.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin
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13. Mühlisch J, Schwering A, Grotzer M, Vince GH, Roggendorf W, Hagemann C, Sörensen N, Rickert CH, Osada N, Jürgens H, Frühwald MC: Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. Oncogene; 2006 Feb 16;25(7):1111-7
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  • [Title] Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood.
  • Supratentorial primitive neuroectodermal tumors (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of the CNS represent a biological and clinical enigma, despite advances in both molecular techniques and clinical management for these two rare embryonal brain tumors of childhood.
  • We thus studied aberrant methylation of the genes RASSF1A and CASP8 and its consequence on expression in cell lines and primary tumors using a combination of semiquantitative methylation specific PCR (MSP), bisulfite sequencing and RT-PCR.
  • In all, 17 samples of autopsy-derived normal appearing brain served as controls.
  • Opposed to control tissues 19/24 sPNET and 4/6 AT/RT demonstrated aberrant methylation for the RASSF1A promoter region.
  • Treatment of cell lines using 5-Aza-2'-deoxycytidine (5AZA) alone or in combination with trichostatin A (TSA) succeeded in re-establishing expression of RASSF1A in cell lines derived from a renal rhabdoid, an AT/RT and a medulloblastoma.
  • A 5' CpG-rich region of CASP8 was methylated in normal tissues and in tumors.
  • However, CASP8 showed inconsistent expression patterns in normal and tumor tissues.
  • Our results indicate that aberrant methylation of the RASSF1A promoter region may be of importance in the origin and progression of sPNET and AT/RT while the analysed 5'-CpG rich region of the CASP8 gene does not seem to play an important role in these tumors.
  • Further studies of epigenetic changes in these rare tumors are warranted as their biology remains obscure and treatment efforts have been rather unsuccessfull.
  • [MeSH-major] Brain Neoplasms / genetics. DNA Methylation. Gene Silencing. Neuroectodermal Tumors, Primitive / genetics. Rhabdoid Tumor / genetics. Teratoma / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 16186793.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hydroxamic Acids; 0 / RASSF1 protein, human; 0 / Tumor Suppressor Proteins; 3X2S926L3Z / trichostatin A; 776B62CQ27 / decitabine; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases; M801H13NRU / Azacitidine
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14. Mora J, Cruz O, Parareda A, Guillen A, Puy R, Massaguer S, de Torres C, Garcia G, Costa JM: Treatment of childhood glial tumors with cisplatin and irinotecan. J Clin Oncol; 2009 May 20;27(15_suppl):10062

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of childhood glial tumors with cisplatin and irinotecan.
  • : 10062 Background: Childhood glial tumors are heterogeneous neoplasias for which non-surgical management is controversial.
  • After a pilot study suggesting that irinotecan/cisplatin (I/C) may be effective in children (Mora et al, Neuro Oncol 2007), we initiated a phase II prospective trial with the aim of avoiding radiation therapy for low grade's (LG) and improve outcome for high grade's (HG).
  • Weekly Irinotecan (50 mg/m2 and 65 mg/m2 the last 2 cycles) and Cisplatin (30 mg/m2) for four consecutive weeks (1 cycle), and a total of 4 cycles was used.
  • Fourteen tumors were WHO grades I-II gliomas (LGG), 10 grade III (6 gliomas, 2 anaplastic ependymomas and 2 AT/RT), and 6 had no biopsy (3 brainstem (BST) and 3 optic-pathway tumors (OPT)).
  • Primary sites included: 4 supratentorial, 8 BST, 9 OPT, 2 cerebellar, and 7 spinal.
  • Prior to the I/C regimen, gross total resection was performed in 7 and biopsy in 14 tumors; 9 patients received chemotherapy and 5 radiotherapy.
  • All but 6 patients, 2 because of C allergy and 4 BST because of progression, completed the protocol, with no grade 3-4 side effects.
  • Twenty (90%) of 22 patients with evaluable clinical symptoms had a complete and rapid response, with objective functional recovery.

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  • (PMID = 27962497.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Palmer S, Wallace D, Bonner M, Raggl R, Chapieski L, Janzen L, Knight S, Boyle R, Armstrong C, Gajjar A: A longitudinal study of processing speed among children treated for medulloblastoma (MB), supratentorial primitive neuroectodermal tumor (SPNET), or atypical teratoid rhabdoid tumor (ATRT). J Clin Oncol; 2009 May 20;27(15_suppl):10028

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A longitudinal study of processing speed among children treated for medulloblastoma (MB), supratentorial primitive neuroectodermal tumor (SPNET), or atypical teratoid rhabdoid tumor (ATRT).
  • High risk (HR, n = 55) patients received 36 - 39.6 Gy CSI and 3D conformal boost to the primary site to 55.8 -59.4 Gy.
  • Average-risk (AR, n=119) patients received 23.4 Gy CSI, 3D conformal boost to the primary site to 55.8 Gy.
  • Those who had posterior fossa syndrome were excluded (n = 26) resulting in 148 patients who completed 459 neuropsychological evaluations using the Woodcock Johnson Tests of Cognitive Abilities-III over a period of 0.03 -4.94 years postdiagnosis.
  • RESULTS: Multivariate modeling revealed a statistically significant decline in processing speed for those < 7 years of age at time of diagnosis (-3.83 points per year, p = 0.003).
  • Those who were > 7 years at diagnosis did not experience a significant change (.86, NS).
  • HR patients experienced greater declines (-.82) than those who were AR (-0.29), but neither slope was statistically significant.
  • CONCLUSIONS: Young age at diagnosis is a prominent risk factor for processing speed impairment among survivors of pediatric embryonal tumors.
  • This study represents the largest comparison of processing speed ability among patients treated for pediatric embryonal tumors with conventional or reduced dose CSI and adjuvant chemotherapy.

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  • (PMID = 27962588.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. McVey GP, Morgan SC, Vergis R, Corbishley C, Thomas K, Cooper C, Horwich A, Huddart R, Dearnaley DP, Parker CC: Benefit of radiotherapy dose escalation in localized prostate cancer with respect to expression of intrinsic markers of hypoxia. J Clin Oncol; 2009 May 20;27(15_suppl):e16068

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e16068 Background: Dose escalation improves the efficacy of prostate cancer radiotherapy (RT) at the cost of increased toxicity.
  • Tumor hypoxia causes radioresistance, so the benefit of RT dose escalation may be greater in more hypoxic cancers.
  • METHODS: Cases had localized prostate cancer treated with neo-adjuvant androgen deprivation and radical RT at the Royal Marsden in two randomized trials of dose escalation (64 vs 74Gy).
  • Tumour expression of three markers (vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α(HIF-1α), and osteopontin) was assessed immunohistochemically using a semi-quantitative scale by a uro-pathologist, and analyzed with respect to freedom from biochemical failure (FFBF) using the Phoenix definition.
  • The benefit of RT dose escalation was similar regardless of VEGF or HIF- 1α expression.
  • CONCLUSIONS: These data generate the hypothesis that osteopontin expression could inform RT dose individualisation.
  • If validated, patients with low tumor expression of osteopontin could elect to receive less toxic, standard dose RT.

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  • (PMID = 27963064.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Lerouge D, Gervais R, Dansin E, Dujon C, Chouaid C, Riviere A, Precheur-Agulhon B, Piolat V, Zalcman G, Lartigau E: A fractionated schedule of oral vinorelbine (NVBo) with cisplatin (CDDP) concomitantly with radiotherapy (RT) after induction chemotherapy (CT) in locally advanced (LA) non-small cell lung cancer (NSCLC): Safety and efficacy results of a phase II trial. J Clin Oncol; 2009 May 20;27(15_suppl):7539

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A fractionated schedule of oral vinorelbine (NVBo) with cisplatin (CDDP) concomitantly with radiotherapy (RT) after induction chemotherapy (CT) in locally advanced (LA) non-small cell lung cancer (NSCLC): Safety and efficacy results of a phase II trial.
  • : 7539 Background: NVB+CDDP as induction and concomitant regimen with RT is a recognized treatment in LA NSCLC (Vokes, J Clin Oncol. 2002).
  • The oral formulation of NVB may simplify the administration and a new fractionated schedule may further improve the results during CT-RT.
  • Non progressive pts received 2 additional cycles of fixed dose NVBo of 20 mg on D1, D3 and D5, + CDDP 80 mg/m<sup>2</sup> on D1 every 3 weeks, combined with a conformal RT at 66 Gy.
  • After CT-RT completion, OR was 55% (CR = 7%), DC = 88%.
  • Furthermore, NVBo taken at home at D3 and D5 reduces the organizational constraints linked to CT-RT.
  • Further follow-up is required in order to assess time to progression and survival.

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  • (PMID = 27963308.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Partap S, Murphy PA, Vogel H, Barnes PD, Edwards MS, Fisher PG: Efficacy and tolerability of intrathecal liposomal cytarabine for central nervous system embryonal tumors. J Clin Oncol; 2009 May 20;27(15_suppl):2064

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  • [Title] Efficacy and tolerability of intrathecal liposomal cytarabine for central nervous system embryonal tumors.
  • METHODS: We reviewed all patients at our institution treated with liposomal cytarabine for primary central nervous system (CNS) embryonal tumors-MB, primitive neuroectodermal tumor (PNET), and atypical teratoid rhabdoid tumor (ATRT).
  • RESULTS: A cohort of 17 patients were treated with liposomal cytarabine at diagnosis of CNS embryonal tumor (2 PNET, 3 ATRT) or relapse (12 MB [7 average-risk, 5 high-risk]); nine had leptomeningeal metastases.
  • A total of 102 doses were administered (lumbar IT 76, Ommaya intraventricular 36) with a mean of six treatments (range 1-16).
  • All six evaluable patients with malignant cerebrospinal fluid (CSF) cytology and treated with at least two doses cleared their spinal fluid (mean 3 doses, range 1-5).
  • No patient developed malignant CSF cytology while receiving liposomal cytarabine.
  • All patients with neoplastic meningitis cleared malignant cells from their spinal fluid after treatment with IT liposomal cytarabine and systemic chemotherapy.
  • Our findings warrant a phase II trial of liposomal cytarabine in newly diagnosed or recurrent CNS embryonal tumors.

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  • (PMID = 27964690.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Cheng YC, Lirng JF, Chang FC, Guo WY, Teng MM, Chang CY, Wong TT, Ho DM: Neuroradiological findings in atypical teratoid/rhabdoid tumor of the central nervous system. Acta Radiol; 2005 Feb;46(1):89-96
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  • [Title] Neuroradiological findings in atypical teratoid/rhabdoid tumor of the central nervous system.
  • PURPOSE: To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) findings of atypical teratoid tumor/rhabdoid tumor (AT/RT) of the central nervous system (CNS).
  • MATERIAL AND METHODS: Twenty cases of CNS AT/RT have been found over the past 23 years in our hospital; these involving 11 boys and 9 girls whose mean age at diagnosis was 5.5 years.
  • RESULTS: AT/RT was located in the cerebellum in 15 cases.
  • Survival time ranged from 2 months to 3 years, with a mean survival of 11.6 months.
  • CONCLUSION: Most cases of AT/RT are located in the cerebellum.
  • However, AT/RT should still remain in the differential diagnosis of brain tumors in young children, especially those located in the cerebellar hemisphere and with eccentric cysts.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Central Nervous System Neoplasms / radiography. Rhabdoid Tumor / pathology. Rhabdoid Tumor / radiography. Teratoma / pathology. Teratoma / radiography

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  • (PMID = 15841745.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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20. Makuria AT, Rushing EJ, McGrail KM, Hartmann DP, Azumi N, Ozdemirli M: Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases. J Neurooncol; 2008 Jul;88(3):321-30
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  • [Title] Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases.
  • Atypical teratoid/rhabdoid (AT/RT) tumor is a rare, highly malignant tumor of the central nervous system (CNS) most commonly found in children less than 5 years of age.
  • Since its histological appearance can be confused with other tumors, especially in adults, separating AT/RT from other neoplasms may be difficult.
  • Radiographically, two tumors were localized in the right fronto-parietal region, one was frontal and the other was found in the left temporal lobe.
  • Immunohistochemical staining showed that the tumor cells were positive for vimentin and reacted variably for keratin, epithelial membrane antigen (EMA), synaptophysin, neurofilament protein, CD34, and smooth muscle actin (SMA).
  • In adult examples of AT/RT, the diagnosis requires a high index of suspicion, with early tissue diagnosis and a low threshold for investigation with INI1 immunohistochemistry to differentiate this entity from other morphologically similar tumors.
  • Although the prognosis is dismal in pediatric population, long term survival is possible in adult AT/RT cases after surgery and adjuvant radiotherapy and chemotherapy.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Rhabdoid Tumor / metabolism. Rhabdoid Tumor / pathology

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  • (PMID = 18369529.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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21. Zarovnaya EL, Pallatroni HF, Hug EB, Ball PA, Cromwell LD, Pipas JM, Fadul CE, Meyer LP, Park JP, Biegel JA, Perry A, Rhodes CH: Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature. J Neurooncol; 2007 Aug;84(1):49-55
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  • [Title] Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature.
  • Atypical teratoid/rhabdoid tumors (AT/RTs) are rare, malignant brain tumors which occur almost exclusively in infants and young children.
  • There have been only 17 cases of AT/RT in adults reported in the medical literature and the rarity of this tumor makes the diagnosis in adults difficult.
  • We describe a case of an AT/RT of the spinal cord in an adult.
  • In consultation with senior pathologists at other institutions, the lesion was initially diagnosed as a rhabdoid meningioma.
  • Subsequently, immunohistochemical studies revealed the absence of INI1 gene expression in the malignant cells, supporting the diagnosis of AT/RT.
  • The patient underwent three additional surgical procedures for recurrent disease throughout the neuraxis secondary to leptomeningeal spread of the tumor.
  • To our knowledge, this is the first case of a spinal atypical teratoid/rhabdoid tumor in an adult fully documented with molecular, immunohistochemical, cytogenetic and autopsy findings.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. Chromosomes, Human, Pair 22 / genetics. DNA-Binding Proteins / genetics. Neoplasm Recurrence, Local / pathology. Rhabdoid Tumor / pathology. Spinal Cord Neoplasms / pathology. Teratoma / pathology. Transcription Factors / genetics

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  • (PMID = 17377740.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Number-of-references] 34
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22. Wang Z, Fan QH, Yu MN, Zhang WM: [Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system]. Zhonghua Bing Li Xue Za Zhi; 2006 Aug;35(8):458-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system].
  • OBJECTIVE: To study the clinicopathologic features and differential diagnosis of atypical teratoid/rhabdoid tumor (AT/RT) occurring in the central nervous system.
  • METHODS: Two cases of AT/RT were studied by hematoxylin-eosin, reticulin and immunohistochemical staining.
  • RESULTS: Histologically, AT/RT was characterized by the presence of rhabdoid cells associated with various degrees of primitive neuroectodermal, epithelial or mesenchymal differentiation.
  • The tumor cells were positive for vimentin, CD99, epithelial membrane antigen, cytokeratin, glial fibrillary acidic protein, S-100 protein, neurofilament, desmin and smooth muscle actin.
  • CONCLUSIONS: AT/RT is a highly malignant tumor occurring in the central nervous system.
  • The tumor is characterized by a heterogeneous histologic and immunohistochemical phenotype.
  • It needs to be distinguished from a number of central nervous system tumors, including medulloblastoma, primitive neuroectodermal tumor, germ cell neoplasm and rhabdoid meningioma.
  • [MeSH-major] Brain Neoplasms / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology

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  • (PMID = 17069697.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 0 / Neurofilament Proteins; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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23. Las Heras F, Pritzker KP: Adult variant of atypical teratoid/rhabdoid tumor: immunohistochemical and ultrastructural confirmation of a rare tumor in the sella tursica. Pathol Res Pract; 2010 Nov 15;206(11):788-91
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  • [Title] Adult variant of atypical teratoid/rhabdoid tumor: immunohistochemical and ultrastructural confirmation of a rare tumor in the sella tursica.
  • Atypical teratoid/rhabdoid tumor (AT/RT) is a distinctive neoplasm of young children characterized by diverse histology and fatal course.
  • We describe the diagnostic problems associated with an AT/RT arising in the sellar region in a 46-year-old female.
  • INI1 protein expression was immunohistochemically determined on tumor tissue.
  • The tumor was composed of large atypical "rhabdoid" cells having macronucleoli and abundant eosinophilic cytoplasm.
  • Immunohistochemistry showed that the tumor cells were positive for vimentin, CD34, CD99, and reacted variably for keratin, synaptophysin, NSE, and SMA.
  • The tumor cells lacked nuclear expression of INI1.
  • AT/RT should be considered when dealing with a malignant neoplasm with rhabdoid features, regardless of age.
  • Immunohistochemistry is of importance in differentiating this entity from primitive neuroectodermal tumors (PNET) and carcinosarcomas.
  • [MeSH-major] Brain Neoplasms / pathology. Rare Diseases. Rhabdoid Tumor / pathology. Sella Turcica / pathology. Teratoma / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinosarcoma / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Neuroectodermal Tumors, Primitive / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20705400.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Takei H, Adesina AM, Mehta V, Powell SZ, Langford LA: Atypical teratoid/rhabdoid tumor of the pineal region in an adult. J Neurosurg; 2010 Aug;113(2):374-9
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  • [Title] Atypical teratoid/rhabdoid tumor of the pineal region in an adult.
  • An atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal tumor most often occurring in the posterior fossa in children younger than 3 years of age.
  • Adult cases of AT/RT are very rare, and 27 cases with a diagnosis of either AT/RT or (malignant) rhabdoid tumor have been reported to date.
  • The authors report an adult case of an AT/RT occurring in the pineal region with molecular cytogenetic and immunohistochemical confirmation.
  • She underwent a subtotal resection of the tumor and was then treated with chemoradiation.
  • Histological sections showed epithelioid cellular sheets of rhabdoid tumor cells with scattered mitotic figures.
  • Immunohistochemically, the tumor cells were diffusely and strongly positive for epithelial membrane antigen and vimentin, and showed focal expression of glial fibrillary acidic protein, pancytokeratin, and neurofilament protein.
  • Histologically, this tumor consisted exclusively of epithelioid tumor cells with rhabdoid features.
  • The differential diagnoses include rhabdoid glioblastoma, metastatic carcinoma, and rhabdoid meningioma.
  • Molecular testing to identify monosomy 22 or deletions of the chromosome 22q11 containing the INI1/hSNF5 gene and/or immunohistochemical staining with INI1 antibody is of great importance for the diagnosis of this tumor.
  • [MeSH-major] Brain Neoplasms / pathology. Pinealoma / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology

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  • (PMID = 19911885.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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25. Yang CS, Jan YJ, Wang J, Shen CC, Chen CC, Chen M: Spinal atypical teratoid/rhabdoid tumor in a 7-year-old boy. Neuropathology; 2007 Apr;27(2):139-44
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  • [Title] Spinal atypical teratoid/rhabdoid tumor in a 7-year-old boy.
  • Reported herein is an unusual case of atypical teratoid/ rhabdoid tumor (AT/RT) of the lumbar spine with an intradural extramedullary location in a 7-year-old boy.
  • Histologically, this tumor contained rhabdoid cells, pale cells, and sickle-shaped embracing cells without primitive neuroectodermal tumor (PNET), mesenchymal or epithelial components.
  • Immunohistochemical staining showed that these tumor cells react positively for epithelial membrane antigen (EMA), vimentin, cytokeratin (AE1/AE3), CD99 and neurofilament protein, but negatively for INI1 antibody.
  • [MeSH-major] Rhabdoid Tumor / pathology. Spinal Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 17494515.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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26. Mohapatra I, Santosh V, Chickabasaviah YT, Mahadevan A, Tandon A, Ghosh A, Chidambaram B, Sampath S, Bhagavatula ID, Chandramouli BA, Kolluri SV, Shankar SK: Histological and immunohistochemical characterization of AT/RT: a report of 15 cases from India. Neuropathology; 2010 Jun;30(3):251-9
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  • [Title] Histological and immunohistochemical characterization of AT/RT: a report of 15 cases from India.
  • Atypical teratoid rhabdoid tumor (AT/RT) is a highly malignant embryonal CNS tumor, generally unresponsive to any form of therapy, uniformly fatal within 1 year.
  • We report 15 cases of AT/RT diagnosed at our center over a period of 5 years (2003-08).
  • Tumors were located in different sites of the neuraxis, posterior fossa being the most common (n = 10) followed by cerebral lobes (n = 3).
  • Radiologically most of the tumors were heterodense and enhancing heterogeneously.
  • The tumors exhibited diverse histological profile that included rhabdoid and PNET areas in all cases, mesenchymal and epithelial areas in 73.3% and 53.3% cases, respectively.
  • Tumor cells displayed a polyphenotypic immunoprofile.
  • [MeSH-major] Central Nervous System Neoplasms / chemistry. Central Nervous System Neoplasms / pathology. Rhabdoid Tumor / chemistry. Rhabdoid Tumor / pathology. Teratoma / chemistry. Teratoma / pathology

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  • (PMID = 19925561.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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27. Biegel JA: Molecular genetics of atypical teratoid/rhabdoid tumor. Neurosurg Focus; 2006;20(1):E11
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  • [Title] Molecular genetics of atypical teratoid/rhabdoid tumor.
  • Rhabdoid tumors are extremely aggressive malignancies that generally occur in infants and young children.
  • The most common locations are the kidney and central nervous system (atypical teratoid/rhabdoid tumor [RT]), although RTs can also arise in most soft-tissue sites.
  • Rhabdoid tumors in all anatomical locations have a similar molecular origin.
  • Mutation or deletion of both copies of the hSNF5/INI1 gene that maps to chromosome band 22q11.2 is observed in approximately 70% of primary tumors.
  • An additional 20 to 25% of tumors have reduced expression at the RNA or protein level, indicative of a loss-of-function event.
  • The complex is recruited to promoters of a large variety of genes involved in cell signaling, growth, and differentiation.
  • This review summarizes what is currently known regarding the molecular genetics of RTs.
  • [MeSH-major] Central Nervous System Neoplasms / genetics. Chromosomes, Human, Pair 22. Kidney Neoplasms / genetics. Molecular Biology / methods. Rhabdoid Tumor / genetics

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  • (PMID = 16459991.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Number-of-references] 44
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28. Moeller KK, Coventry S, Jernigan S, Moriarty TM: Atypical teratoid/rhabdoid tumor of the spine. AJNR Am J Neuroradiol; 2007 Mar;28(3):593-5
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  • [Title] Atypical teratoid/rhabdoid tumor of the spine.
  • SUMMARY: Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant central nervous system neoplasm usually seen in young children and infants.
  • Prognosis for AT/RT is poor, with most patients dying within 1 year of presentation.
  • AT/RT most commonly occurs intracranially.
  • We present a case of AT/RT occurring in the thoracolumbar spine of a child and review available clinical and imaging findings in previously reported cases of spinal AT/RT.
  • [MeSH-major] Magnetic Resonance Imaging. Rhabdoid Tumor / pathology. Spinal Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 17353344.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Raisanen J, Biegel JA, Hatanpaa KJ, Judkins A, White CL, Perry A: Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults. Brain Pathol; 2005 Jan;15(1):23-8
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  • [Title] Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults.
  • Atypical teratoid/rhabdoid tumors (AT/RTs) are rare, malignant brain tumors that usually occur in the posterior fossa.
  • Both AT/RT and the analogous tumor outside the brain, malignant rhabdoid tumor, share a polyphenotypic immunoprofile and frequent 22q deletions with inactivation of the IN11/hSNF5 gene.
  • Reports, so far, indicate that AT/RTs occur almost exclusively in children, most of whom are 5-years-old or less.
  • The rarity of the tumor and the polyphenotypic immunoprofile, characterized by antigen expression that is often patchy, make diagnosis in adults difficult and controversial.
  • We describe three AT/RTs in adults in which the diagnoses were supported by detection of 22q11.2 deletions, INI1 mutation and/or loss of INI1 protein expression.
  • Two tumors occurred in the sella or sellar region and one in the cerebellum.
  • These molecular findings confirm the occurrence of AT/RTs in adults.
  • Although rare, AT/RT should be considered in the differential diagnosis of poorly differentiated intracranial tumors in adults.
  • [MeSH-major] Brain Neoplasms / genetics. Chromosome Deletion. Chromosomes, Human, Pair 22 / genetics. Rhabdoid Tumor / genetics. Teratoma / genetics

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  • (PMID = 15779233.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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30. Narendran A, Coppes L, Jayanthan A, Coppes M, Teja B, Bernoux D, George D, Strother D: Establishment of atypical-teratoid/rhabdoid tumor (AT/RT) cell cultures from disseminated CSF cells: a model to elucidate biology and potential targeted therapeutics. J Neurooncol; 2008 Nov;90(2):171-80
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  • [Title] Establishment of atypical-teratoid/rhabdoid tumor (AT/RT) cell cultures from disseminated CSF cells: a model to elucidate biology and potential targeted therapeutics.
  • Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant central nervous system neoplasm that usually affects infants and young children.
  • In this report, we describe culture conditions that enabled the sustained growth of tumor cells obtained from the cerebrospinal fluid (CSF) of an infant with AT/RT.
  • These cells retained the morphological and biomarker characteristics of the original tumor.
  • IGF-IR activity is consistent with data from other established AT/RT cell lines.
  • Inhibition of IGF-IR by the small molecular weight inhibitor AEW541 led to growth suppression of cultured AT/RT cells.
  • We also compared cultured AT/RT cells to established cell lines to identify consistent drug sensitivity patterns among these cells.
  • In addition to previously described cell lines and xenograft models, continuous culture of CSF derived cells may also provide an effective way to study the biology of AT/RT and to identify potential targets for future therapeutics for this tumor.
  • [MeSH-major] Platelet Aggregation Inhibitors / therapeutic use. Rhabdoid Tumor / cerebrospinal fluid. Rhabdoid Tumor / drug therapy
  • [MeSH-minor] Actins / metabolism. Cell Proliferation. Chromosomal Proteins, Non-Histone / metabolism. DNA-Binding Proteins / metabolism. Dose-Response Relationship, Drug. Glial Fibrillary Acidic Protein / metabolism. Humans. Infant. Inhibitory Concentration 50. Male. Models, Biological. Nuclear Proteins / metabolism. Receptor Protein-Tyrosine Kinases / metabolism. Transcription Factors / metabolism. Tumor Cells, Cultured / pathology. Vimentin / metabolism

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  • (PMID = 18651103.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Actins; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Glial Fibrillary Acidic Protein; 0 / Nuclear Proteins; 0 / Platelet Aggregation Inhibitors; 0 / SMARCB1 protein, human; 0 / Transcription Factors; 0 / Vimentin; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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31. Ertan Y, Sezak M, Turhan T, Kantar M, Erşahin Y, Mutluer S, Vergin C, Oniz H, Akalin T: Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. Childs Nerv Syst; 2009 Jun;25(6):707-11
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  • [Title] Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases.
  • BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive infantile neoplasm of uncertain origin.
  • This study was performed to assess the clinicopathologic and immunohistochemical features of four AT/RT cases.
  • Tumors were located in the cerebellum (two cases), frontoparietal lobe (one case), and third ventricle (one case).
  • Histopathologically, the tumors were composed of rhabdoid cells and undifferentiated small cells mixed with epithelial or mesenchymal components.
  • However, one of the tumors was composed predominantly of a mesenchymal component mimicking a sarcoma.
  • All of the patients died within a mean of 14 months due to tumor progression despite the chemotherapy.
  • In conclusion, AT/RTs are aggressive tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology
  • [MeSH-minor] Actins / analysis. Brain / pathology. Brain Chemistry. Child. Child, Preschool. Chromosomal Proteins, Non-Histone / analysis. DNA-Binding Proteins / analysis. Desmin / analysis. Diagnosis, Differential. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Infant. Keratins / analysis. Male. Mucin-1 / analysis. S100 Proteins / analysis. Synaptophysin / analysis. Transcription Factors / analysis. Vimentin / analysis

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  • [CommentIn] Childs Nerv Syst. 2009 Nov;25(11):1387; author reply 1389 [19636570.001]
  • (PMID = 19212771.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 0 / S100 Proteins; 0 / SMARCB1 protein, human; 0 / Synaptophysin; 0 / Transcription Factors; 0 / Vimentin; 68238-35-7 / Keratins
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32. Seno T, Kawaguchi T, Yamahara T, Sakurai Y, Oishi T, Inagaki T, Yamanouchi Y, Asai A, Kawamoto K: An immunohistochemical and electron microscopic study of atypical teratoid/rhabdoid tumor. Brain Tumor Pathol; 2008;25(2):79-83
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  • [Title] An immunohistochemical and electron microscopic study of atypical teratoid/rhabdoid tumor.
  • We report two infant cases with atypical teratoid/rhabdoid tumor (AT/RT) located in the cerebellar vermis and spinal cord.
  • MRI showed the tumors were isointense on T1-weighted images and mixed intensity of isointense and slight high intensity on T2-weighted images.
  • Postcontrast MRI demonstrated clear margin of tumor and heterogeneous strong enhancement.
  • It was difficult to differentiate the tumor from medulloblastoma by hematoxylin and eosin staining.
  • However, immunohistochemical staining showed that these tumor cells react positively for cytokeratin, smooth muscle actin (SMA), and epithelial membrane antigen (EMA) and helped us with the differentiation.
  • Electron microscopic study has confirmed the presence of mesenchymal components, such as filaments and desmosome junctions in the rhabdoid cells, but no neuronal components.
  • The tumors rapidly increased in size, showing high MIB-1 index, and the prognosis was gave.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Rhabdoid Tumor / pathology. Spinal Cord Neoplasms / pathology. Teratoma / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Coloring Agents. Eosine Yellowish-(YS). Female. Fluorescent Dyes. Hematoxylin. Humans. Immunohistochemistry. Infant. Magnetic Resonance Imaging. Microscopy, Electron. Neoplasm Proteins / metabolism. Nerve Tissue Proteins / metabolism. Organelles / pathology. Organelles / ultrastructure. Tissue Fixation. Tomography, X-Ray Computed

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  • (PMID = 18987833.001).
  • [ISSN] 1433-7398
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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33. Klos D, Lovecek M, Srovnal J, Benedíková A, Růzková V, Radová L, Hajdúch M, Neoral C, Havlík R: [Possibility of using the determination of minimal residual disease in pancreatic adenocarcinoma using real-time RT-PCR--a pilot study]. Cas Lek Cesk; 2010;149(2):69-73
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  • [Title] [Possibility of using the determination of minimal residual disease in pancreatic adenocarcinoma using real-time RT-PCR--a pilot study].
  • [Transliterated title] Moznosti vyuzití stanovení minimální reziduální choroby u adenokarcinomu pankeatu pomocí metodiky real-tim RT-PCR--pilotní studie.
  • BACKGROUND: Minimal residual disease in patients with pancreatic cancer is defined as the presence of isolated tumor cells in the patient's body, in which the primary tumor was removed and is currently without clinical signs of disease.
  • These isolated tumor cells may be described as precursors of micrometastases.
  • Assessment of MRD in patients with this highly malignant disease could eliminate burdensome implementation of surgery in patients with systematic dissemination of molecular disease and provide a more precise prognosis.
  • Samples of peripheral and portal blood, bone marrow, peritoneal lavage and of the tumor itself were analyzed by real-time PCR which measured the expression of hTERT (telomerase), EGFR1 (receptor for epidermal growth factor) and CEA (carcinoembryonic antigen).
  • CONCLUSIONS: The results of this pilot study demonstrated a high sensitivity and specificity of the RT-PCR method for detecting circulating tumor cells in patients with pancreatic cancer.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoembryonic Antigen / analysis. Pancreatic Neoplasms / diagnosis. Reverse Transcriptase Polymerase Chain Reaction
  • [MeSH-minor] Female. Humans. Male. Neoplasm, Residual. Receptor, Epidermal Growth Factor / analysis. Sensitivity and Specificity. Telomerase / analysis

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  • (PMID = 20662469.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.7.49 / Telomerase
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34. Nicolaides T, Tihan T, Horn B, Biegel J, Prados M, Banerjee A: High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system. J Neurooncol; 2010 May;98(1):117-23
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  • [Title] High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system.
  • Atypical Teratoid/Rhabdoid tumors (AT/RT) of the central nervous system are rare but aggressive tumors of childhood.
  • Nine consecutive children (median age 21 months) were diagnosed with AT/RT at the University of California San Francisco Childrens Hospital from 1997 to 2007 and treated with this aggressive approach.
  • Two of nine patients treated for AT/RT at our institution with high dose chemotherapy and autologous bone marrow transplant are long-term survivors, suggesting that a subset of patients can be cured with this approach.

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  • [Cites] Am J Surg Pathol. 2002 Feb;26(2):266-70 [11812951.001]
  • [Cites] J Clin Oncol. 2009 Jan 20;27(3):385-9 [19064966.001]
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  • (PMID = 19936623.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA046274-18; United States / NCI NIH HHS / CA / R01 CA046274; United States / NCI NIH HHS / CA / CA46274; United States / NCI NIH HHS / CA / T32 CA108462; United States / NCI NIH HHS / CA / CA046274-18; United States / NCI NIH HHS / CA / T32 CA108462-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS184133; NLM/ PMC2880232
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35. Strauss B, Brix C, Fischer S, Leppert K, Füller J, Roehrig B, Schleussner C, Wendt TG: The influence of resilience on fatigue in cancer patients undergoing radiation therapy (RT). J Cancer Res Clin Oncol; 2007 Aug;133(8):511-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The influence of resilience on fatigue in cancer patients undergoing radiation therapy (RT).
  • PURPOSE: The primary goal of the study was to determine if resilience influences fatigue in a consecutive sample of cancer patients treated with radiotherapy (RT) at the beginning and at the end of the treatment.
  • METHODS: Out of an initial sample of 250 patients, 239 could be assessed at the beginning of their RT.
  • Two hundred and eight patients were reassessed at the end of RT 4-8 weeks later.
  • Fatigue increased during RT.
  • Changes of fatigue scores during RT depended on initial scores, decrease in Hb and the patients' experience with RT.
  • Resilience could not be determined as a predictor of changes in fatigue during RT.
  • CONCLUSIONS: The study confirmed that fatigue is an important problem among RT patients.
  • Resilience turned out to powerfully predict the patients' fatigue at least early in RT.
  • On the other hand, resilience seems to have little influence on treatment related fatigue during RT.
  • [MeSH-minor] Adaptation, Psychological. Adult. Aged. Female. Health Status. Humans. Karnofsky Performance Status. Male. Middle Aged. Predictive Value of Tests. Radiotherapy / adverse effects. Radiotherapy Dosage. Regression Analysis. Surveys and Questionnaires

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  • (PMID = 17576595.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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36. Rayz VL, Boussel L, Ge L, Leach JR, Martin AJ, Lawton MT, McCulloch C, Saloner D: Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms. Ann Biomed Eng; 2010 Oct;38(10):3058-69
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  • [Title] Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms.
  • In our previous work, patient-specific computational fluid dynamics (CFD) models were constructed from MRI data for three patients who had fusiform basilar aneurysms that were thrombus-free and then proceeded to develop intraluminal thrombus.
  • In this study, we investigated the effect of increased flow residence time (RT) by modeling passive scalar advection in the same aneurysmal geometries.
  • Non-Newtonian pulsatile flow simulations were carried out in base-line geometries and a new postprocessing technique, referred to as "virtual ink" and based on the passive scalar distribution maps, was used to visualize the flow and estimate the flow RT.
  • The flow RT at different locations adjacent to aneurysmal walls was calculated as the time the virtual ink scalar remained above a threshold value.
  • The RT values obtained in different areas were then correlated with the location of intra-aneurysmal thrombus observed at a follow-up MR study.
  • The correlation analysis determined a significant relationship between regions where CFD predicted either an increased RT or low WSS and the regions where thrombus deposition was observed to occur in vivo.
  • A model including both low WSS and increased RT predicted thrombus-prone regions significantly better than the models with RT or WSS alone.

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  • (PMID = 20499185.001).
  • [ISSN] 1573-9686
  • [Journal-full-title] Annals of biomedical engineering
  • [ISO-abbreviation] Ann Biomed Eng
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K25 NS059891; United States / NINDS NIH HHS / NS / R01 NS059944; United States / NINDS NIH HHS / NS / K25NS059891; United States / NINDS NIH HHS / NS / R01NS059944
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2940011
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37. Koral K, Gargan L, Bowers DC, Gimi B, Timmons CF, Weprin B, Rollins NK: Imaging characteristics of atypical teratoid-rhabdoid tumor in children compared with medulloblastoma. AJR Am J Roentgenol; 2008 Mar;190(3):809-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging characteristics of atypical teratoid-rhabdoid tumor in children compared with medulloblastoma.
  • OBJECTIVE: The purpose of our study was to compare the imaging characteristics of atypical teratoid-rhabdoid tumor with medulloblastoma and seek distinguishing features that can aid in preoperative diagnosis.
  • MATERIALS AND METHODS: Preoperative MRI examinations of 55 patients (36 medulloblastomas and 19 atypical teratoid-rhabdoid tumors) were analyzed retrospectively.
  • Imaging characteristics of atypical teratoid-rhabdoid tumor and medulloblastoma were assessed with conventional MRI and CT.
  • Diffusion-weighted imaging (DWI) was available in 27 patients (19 medulloblastomas and eight atypical teratoid-rhabdoid tumors).
  • Apparent diffusion coefficient (ADC) values were calculated for 14 medulloblastomas and six atypical teratoid-rhabdoid tumors.
  • RESULTS: Both atypical teratoid-rhabdoid tumors in general and infratentorial atypical teratoid-rhabdoid tumors presented at a younger age than medulloblastomas.
  • Eleven of 19 atypical teratoid-rhabdoid tumors were infratentorial.
  • Cerebellopontine angle (CPA) involvement was more frequent (8/11, 72.7%) in atypical teratoid-rhabdoid tumor than in medulloblastoma (4/36, 11.1%) (p < 0.001).
  • Intratumoral hemorrhage was more common in atypical teratoid-rhabdoid tumor (9/19, 47.4%) than in medulloblastoma (2/36, 5.6%) (p < 0.0001).
  • All atypical teratoid-rhabdoid tumors and all medulloblastomas for which DWI was available displayed increased signal intensity on DWI compared with normal brain parenchyma.
  • The mean ADC values for tumor types were not significantly different.
  • CONCLUSION: Atypical teratoid-rhabdoid tumor presents at a younger age than medulloblastoma.
  • Although atypical teratoid-rhabdoid tumor and medulloblastoma display similar imaging characteristics on conventional MRI, CPA involvement and intratumoral hemorrhage are more common in atypical teratoid-rhabdoid tumor.
  • If a pediatric posterior fossa mass that displays restricted diffusion is involving the CPA, atypical teratoid-rhabdoid tumor is a more likely consideration than medulloblastoma.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Magnetic Resonance Imaging. Medulloblastoma / diagnosis. Rhabdoid Tumor / diagnosis. Teratoma / diagnosis. Tomography, X-Ray Computed


38. Rodríguez J, Navallas J, Gila L, Rodríguez I, Malanda A: Analysis of the relationship between the rise-time and the amplitude of single-fibre potentials in human muscles. J Electromyogr Kinesiol; 2010 Dec;20(6):1249-58

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of the relationship between the rise-time and the amplitude of single-fibre potentials in human muscles.
  • Using the core-conductor theory, a single fibre action potential (SFAP) can be expressed as the convolution of a biolectrical source and a weight function.
  • The present work evaluates the relationship between the SFAP peak-to-peak amplitude (V(pp)) and peak-to-peak interval (rise-time, RT) at different fibre-to-electrode distances using simulated signals obtained by the D-D model as well as real recordings.
  • We used the observed changes in RT and V(pp) within each SFAP set as a point of reference with which to evaluate how closely the relationship between RT and V(pp) provided by the D-D model reflects real data.
  • We found that half of the recorded SFAP sets had rise-times higher than those generated by the D-D model.
  • We also showed the influence of the IAP spatial length on the sensitivity of RT and V(pp) with radial distance.

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  • [Copyright] Copyright © 2010. Published by Elsevier Ltd.
  • (PMID = 20692181.001).
  • [ISSN] 1873-5711
  • [Journal-full-title] Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
  • [ISO-abbreviation] J Electromyogr Kinesiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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39. Umredkar A, Bal A, Vashista RK: Atypical teratoid/rhabdoid tumour of the central nervous system in adult: case report. Br J Neurosurg; 2010 Dec;24(6):699-704

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical teratoid/rhabdoid tumour of the central nervous system in adult: case report.
  • Atypical teratoid/rhabdoid tumours (AT/RT) are aggressive neoplasms of the central nervous system occurring mainly in the paediatric population.
  • We reported a 32-year-old male patient who was admitted in emergency in unconscious state.
  • The neoplasm was localised in the left frontal region and was totally excised.
  • The histological and immunohistochemical report revealed AT/RT.
  • This unusual presentation underlines the necessity of considering this devastating neoplasm in the differential diagnosis of malignant brain tumours of adults.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology

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  • (PMID = 21070155.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Singh A, Jairajpuri Z, Gupta V, Sharma S, Chand K: Atypical teratoid/rhabdoid tumor of the central nervous system associated with congenital cataract. Indian J Pathol Microbiol; 2008 Jul-Sep;51(3):389-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical teratoid/rhabdoid tumor of the central nervous system associated with congenital cataract.
  • Atypical teratoid /rhabdoid tumor (AT/RT) of the central nervous system is a rare but highly aggressive neoplasm that usually affects young children and infants and follows a rapidly fatal course.
  • We report a case of AT/RT in a 3-month-old male infant who also had coincidental unilateral congenital cataract even though there was no associated congenital infectious disease.
  • [MeSH-major] Central Nervous System Neoplasms / diagnosis. Central Nervous System Neoplasms / pathology. Rhabdoid Tumor / diagnosis. Rhabdoid Tumor / pathology. Teratoma / diagnosis. Teratoma / pathology
  • [MeSH-minor] Cataract / complications. Cataract / congenital. Central Nervous System / pathology. Fatal Outcome. Humans. Infant. Male

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  • (PMID = 18723966.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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41. Judkins AR, Burger PC, Hamilton RL, Kleinschmidt-DeMasters B, Perry A, Pomeroy SL, Rosenblum MK, Yachnis AT, Zhou H, Rorke LB, Biegel JA: INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. J Neuropathol Exp Neurol; 2005 May;64(5):391-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma.
  • Central nervous system atypical teratoid/rhabdoid tumor (AT/RT) and choroid plexus carcinoma (CPC) are rare, highly malignant tumors that predominantly arise in infants and young children.
  • AT/RT is characterized by deletions and/or mutations of the INI1 tumor-suppressor gene on chromosome band 22q11.2.
  • Negative staining of tumor cells resulting from inactivation of the INI1 gene is a consistent feature of AT/RT.
  • The purpose of the present study was to determine if immunohistochemical staining with an INI1 antibody would provide a sensitive means of distinguishing between CPC and AT/RT.
  • We examined 28 tumors with a submitted diagnosis of CPC.
  • Twenty-one CPCs showed retained expression of INI1 and seven tumors showed loss of INI1 expression.
  • Cytogenetic, FISH, and/or INI1 mutation results were also available for 13 tumors.
  • In three of the seven cases, monosomy 22 was the only cytogenetic abnormality, suggestive of AT/RT.
  • However, monosomy 22 was also identified in 3 tumors with complex karyotypes that retained INI1 expression.
  • The 7 tumors that were immunonegative for INI1 had features that were consistent with AT/RT.
  • Immunostaining for INI1 protein is retained in the majority of CPC and is lost in AT/RT.
  • This expression pattern seems to better define the 2 groups of tumors than does light or electron microscopy, routine immunohistochemistry, or cytogenetic analysis alone.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma / metabolism. Choroid Plexus Neoplasms / metabolism. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic / physiology. Teratoma / metabolism

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  • (PMID = 15892296.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA46274; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Mucin-1; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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42. Biswas A, Goyal S, Puri T, Das P, Sarkar C, Julka PK, Bakhshi S, Rath GK: Atypical teratoid rhabdoid tumor of the brain: case series and review of literature. Childs Nerv Syst; 2009 Nov;25(11):1495-500
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  • [Title] Atypical teratoid rhabdoid tumor of the brain: case series and review of literature.
  • INTRODUCTION: Intracranial atypical teratoid rhabdoid tumor is an uncommon malignancy with a dismal outcome.
  • Commonly misdiagnosed over the decades as primitive neuroectodermal tumor of the brain, it has dramatically different biological behavior.
  • DISCUSSION: We herein report a case series of five patients diagnosed and treated as atypical teratoid rhabdoid tumor of the brain in a major cancer center in north India.
  • We have also analyzed the clinical, histopathological, and radiological features and the therapeutic options of this enigmatic tumor.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / pathology. Rhabdoid Tumor / diagnosis. Rhabdoid Tumor / pathology. Teratoma / diagnosis. Teratoma / pathology

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  • (PMID = 19484251.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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43. Niwa T, Aida N, Tanaka M, Okubo J, Sasano M, Shishikura A, Fujita K, Ito S, Tanaka Y, Kigasawa H: Diffusion-weighted imaging of an atypical teratoid/rhabdoid tumor of the cervical spine. Magn Reson Med Sci; 2009;8(3):135-8
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  • [Title] Diffusion-weighted imaging of an atypical teratoid/rhabdoid tumor of the cervical spine.
  • Spinal atypical teratoid/rhabdoid tumor (AT/RT) is a rare, aggressive malignant neoplasm of the central nervous system usually seen in young children and infants.
  • We present diffusion-weighted imaging (DWI) findings for an intradural extramedullary AT/RT in the cervical spine of a 6-year-old boy.
  • High signal on DWI and low apparent diffusion coefficients may represent high cellularity of the tumor.
  • These findings indicated a highly malignant tumor.
  • [MeSH-major] Cervical Vertebrae. Diffusion Magnetic Resonance Imaging / methods. Rhabdoid Tumor / pathology. Spinal Cord Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 19783876.001).
  • [ISSN] 1880-2206
  • [Journal-full-title] Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
  • [ISO-abbreviation] Magn Reson Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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44. Agrawal A, Bhake A, Cincu R: Giant lumbar paraspinal atypical teratoid/rhabdoid tumor in a child. J Cancer Res Ther; 2009 Oct-Dec;5(4):318-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant lumbar paraspinal atypical teratoid/rhabdoid tumor in a child.
  • Atypical teratoid/rhabdoid tumor (AT/RT) is a highly aggressive and uncommon tumor of the central nervous system, primarily affecting young children.
  • AT/RT of the paraspinal region with involvement of the spine and spinal cord is extremely rare, with only few case reports in the literature.
  • We report an unusual case of giant lumbar paraspinal AT/RT with intraspinal extension in a previously healthy 18-month-old female child.
  • [MeSH-major] Rhabdoid Tumor / pathology. Spinal Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 20160373.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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45. Parwani AV, Stelow EB, Pambuccian SE, Burger PC, Ali SZ: Atypical teratoid/rhabdoid tumor of the brain: cytopathologic characteristics and differential diagnosis. Cancer; 2005 Apr 25;105(2):65-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical teratoid/rhabdoid tumor of the brain: cytopathologic characteristics and differential diagnosis.
  • BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is a highly aggressive neoplasm with a unique cytogenetic profile.
  • Although the clinicopathologic and radiologic features of AT/RT have been described previously, to the authors' knowledge the cytomorphologic profile of this tumor has not been studied well.
  • METHODS: Nine samples of AT/RT from 8 patients were analyzed from the pathology files of 2 large institutions in a 10-year period (1993-2002).
  • RESULTS: There were 4 males and 4 females who ranged in age from 1-16 years (mean age, 7.1 years).
  • Cytomorphologic features consisted of hypercellularity (eight of eight tumors); predominantly large tissue fragments with tumor cells surrounding proliferating capillaries depicting a "papillary-like" appearance (five of eight tumors); large, round, "plasmacytoid" cells and characteristic "rhabdoid" cells (i.e., intermediate-sized cells with granular to fibrillary, brightly eosinophilic cytoplasm with or without globoid "inclusions"; large, eccentrically located, round-to-reniform nuclei with single prominent nucleoli; eight of eight tumors); small, round, primitive "neuronal-appearing" cells with a high nuclear to cytoplasmic ratio (five of eight patients); and bizarre, multinucleated giant cells (two of eight tumors).
  • Also seen were numerous apoptotic bodies, mitoses, and significant necrosis (seven of eight tumors), and prominent dystrophic calcification (four of eight tumors).
  • CONCLUSIONS: AT/RT is extremely rare.
  • The differential diagnosis includes medulloblastoma (in cerebellar tumors), primitive neuroectodermal tumor (in suprasellar tumors), choroid plexus carcinoma, and malignant glioma.
  • [MeSH-major] Brain Neoplasms / pathology. Rhabdoid Tumor / pathology
  • [MeSH-minor] Adolescent. Child, Preschool. Diagnosis, Differential. Female. Glioma / pathology. Humans. Infant. Male. Medulloblastoma / pathology. Neuroectodermal Tumors, Primitive. Retrospective Studies


46. Nebbia G, Sabin CA, Dunn DT, Geretti AM, UK Collaborative Group on HIV Drug Resistance, UK Collaborative HIV Cohort (CHIC) Study Group: Emergence of the H208Y mutation in the reverse transcriptase (RT) of HIV-1 in association with nucleoside RT inhibitor therapy. J Antimicrob Chemother; 2007 May;59(5):1013-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Emergence of the H208Y mutation in the reverse transcriptase (RT) of HIV-1 in association with nucleoside RT inhibitor therapy.
  • OBJECTIVES: The aim of the study was to determine whether mutations at RT codon 208 are associated with nucleoside RT inhibitor (NRTI) exposure, NRTI resistance patterns and HIV-1 subtype.
  • METHODS: Six thousand three hundred and fifty two genotypic resistance tests linked to a clinical database were analysed.
  • The prevalence of H208Y declined over time, being highest in 1998 (9.9%) and lowest in 2003 (0.9%) (P=0.0001).
  • CONCLUSIONS: There is a strong association between H208Y and NRTI experience, particularly in persons with Subtype B harbouring multiple NRTI resistance mutations.
  • These findings indicate an accessory role for H208Y in NRTI resistance.
  • [MeSH-major] Anti-HIV Agents / therapeutic use. Drug Resistance, Viral. HIV Infections / drug therapy. HIV Reverse Transcriptase / genetics. HIV-1 / drug effects. Reverse Transcriptase Inhibitors / therapeutic use

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  • (PMID = 17356061.001).
  • [ISSN] 0305-7453
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MRC/ G0600337; United Kingdom / Medical Research Council / / MRC/ MC/ U122886351
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Reverse Transcriptase Inhibitors; EC 2.7.7.49 / HIV Reverse Transcriptase
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47. Katenkamp K, Richter P, Slatosch T, Katenkamp D, Berndt A: [Simultaneous analysis of t(X;18) by FISH- und SYT/SSX-RT-PCR in synovial sarcoma]. Pathologe; 2005 Mar;26(2):111-6
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  • [Title] [Simultaneous analysis of t(X;18) by FISH- und SYT/SSX-RT-PCR in synovial sarcoma].
  • [Transliterated title] Diagnostik des Synovialsarkoms Simultane t(X;18) FISH- und SYT/SSX-RT-PCR-Analyse.
  • In these cases the detection of the t(X;18) translocation by FISH and RT-PCR is diagnostically extremely helpful.
  • This study was aimed at the question whether or not simultaneous use of both methods is required for evidence of t(X;18) translocation.Paraffin-embedded tumour specimens from 53 patients were included in the study which were considered to be possible synovial sarcomas on the basis of histological aspect and immunohistochemical profile.
  • Detection of t(X;18) was performed using FISH and RT-PCR simultaneously.
  • In 72% of these 39 cases FISH and RT-PCR showed identical negative or positive results.
  • Nevertheless tumour biological and methodical reasons have an important influence on both methods.
  • Consequently in difficult cases simultaneous FISH and RT-PCR analysis is necessary for a clear evidence of t(X;18) translocation.
  • [MeSH-minor] Humans. In Situ Hybridization, Fluorescence. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15662499.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / RNA, Neoplasm
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48. Jackson EM, Shaikh TH, Zhang F, Wainwright LM, Storm PB, Hakonarson H, Zackai EH, Biegel JA: Atypical teratoid/rhabdoid tumor in a patient with Beckwith-Wiedemann syndrome. Am J Med Genet A; 2007 Aug 1;143A(15):1767-70
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  • [Title] Atypical teratoid/rhabdoid tumor in a patient with Beckwith-Wiedemann syndrome.
  • Beckwith-Wiedemann syndrome (BWS) is a genetic disorder associated with an increased risk of childhood tumors.
  • Here we describe a patient with BWS who developed a central nervous system atypical teratoid/rhabdoid tumor (AT/RT).
  • To our knowledge, despite the known cancer predisposition, this patient is the first described with BWS to develop an AT/RT.
  • Due to the high propensity of these patients to develop childhood tumors, in addition to routine diagnostic tests, analysis of the tumor DNA using the Illumina Infinium whole-genome genotyping 550K Beadchip was performed to investigate a possible common underlying mechanism for his BWS and AT/RT.
  • The only alteration detected was monosomy 22, which was accompanied by a somatic mutation in the INI1 rhabdoid tumor gene.
  • These results suggest that, despite an underlying cancer predisposition, the occurrence of BWS and AT/RT in this patient may be unrelated.
  • [MeSH-major] Beckwith-Wiedemann Syndrome / genetics. Rhabdoid Tumor / complications. Teratoma / complications
  • [MeSH-minor] Brain / radiography. Humans. Infant. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17603804.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Arita K, Sugiyama K, Sano T, Oka H: Atypical teratoid/rhabdoid tumour in sella turcica in an adult. Acta Neurochir (Wien); 2008 May;150(5):491-5; discussion 496

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  • [Title] Atypical teratoid/rhabdoid tumour in sella turcica in an adult.
  • Although atypical teratoid rhabdoid tumours preferentially arise in the posterior fossa of infants, we encountered a 56 year old woman with an atypical teratoid rhabdoid tumour located in the sella.
  • Magnetic resonance imaging demonstrated an intrasellar tumour impinging on the right cavernous sinus.
  • Microscopically, the tumour was composed of cells with rhabdoid features; we observed atypia, eccentric nuclei, and intracytoplasmic inclusion bodies.
  • The tumour cells were positive for vimentin, epithelial membrane antigen, and neurofilament, but negative for INI1.
  • Despite extended local brain and whole-spine irradiation she died of neural axis dissemination.
  • [MeSH-major] Rhabdoid Tumor / diagnosis. Rhabdoid Tumor / therapy. Sella Turcica. Skull Neoplasms / diagnosis. Skull Neoplasms / therapy

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  • (PMID = 18309453.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
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50. Kazan S, Göksu E, Mihci E, Gökhan G, Keser I, Gürer I: Primary atypical teratoid/rhabdoid tumor of the clival region. Case report. J Neurosurg; 2007 Apr;106(4 Suppl):308-11
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  • [Title] Primary atypical teratoid/rhabdoid tumor of the clival region. Case report.
  • An atypical teratoid/rhabdoid tumor of the central nervous system (CNS) is a rare, aggressive neoplasm found in infants and children that has similar characteristics to CNS primitive neuroectodermal tumors/medulloblastomas.
  • The authors present the case of a patient with an atypical teratoid/rhabdoid tumor and discuss the imaging, histopathological, immunohistochemical, and cytogenetic findings.
  • Tumor cells displayed positive reactions for vimentin, epithelial membrane antigen, and cytokeratin, and they displayed no reaction for glial fibrillary acidic protein, desmin, and actin.
  • The phenotype of an atypical teratoid/rhabdoid tumor appears heterogeneous when examined by histological, immunohistochemical, and genetic analysis.
  • The authors describe the case of a 4-year-old boy who harbored an atypical teratoid/rhabdoid tumor in the clivus, which appeared as a chordoma on neuroimages.
  • To their knowledge, this location of an atypical teratoid/rhabdoid tumor has not been described in the literature.
  • [MeSH-major] Cranial Fossa, Posterior. Rhabdoid Tumor / pathology. Skull Base Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 17465367.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Verma A, Morriss C: Atypical teratoid/rhabdoid tumor of the optic nerve. Pediatr Radiol; 2008 Oct;38(10):1117-21
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  • [Title] Atypical teratoid/rhabdoid tumor of the optic nerve.
  • We report a rare case of atypical teratoid/rhabdoid tumor that presented with imaging findings similar to those of optic pathway glioma.
  • The diagnosis of atypical teratoid/rhabdoid tumor was determined following surgical resection of the tumor by collective histologic and immunohistochemical staining, and cytogenetic analysis.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Optic Nerve Neoplasms / diagnosis. Rhabdoid Tumor / diagnosis. Teratoma / diagnosis

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  • (PMID = 18696060.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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52. Kordes U, Gesk S, Frühwald MC, Graf N, Leuschner I, Hasselblatt M, Jeibmann A, Oyen F, Peters O, Pietsch T, Siebert R, Schneppenheim R: Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor. Genes Chromosomes Cancer; 2010 Feb;49(2):176-81
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  • [Title] Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor.
  • The SMARCB1 gene status in 50 patients with atypical teratoid rhabdoid tumor and/or malignant rhabdoid tumor recruited to a German registry was prospectively analyzed with FISH and PCR.
  • Germline mutations were identified in 10 of 41 patients with CNS disease, including three large heterozygous deletions, six truncating mutations and one donor splice site mutation.
  • No germline mutation was found in nine patients without CNS disease.
  • Patients with germline mutation had a lower median age at diagnosis in comparison to those without detectable germline mutation (5.5 vs. 13 months, P = 0.001), a higher rate of primary multicentric CNS disease (5/10 vs. 5/36) and synchronous or metachronous mixed CNS and extracranial disease (4/10 vs. 1/36).
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Mutation. Rhabdoid Tumor / genetics. Transcription Factors / genetics

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  • (PMID = 19902524.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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53. Kao CL, Chiou SH, Chen YJ, Singh S, Lin HT, Liu RS, Lo CW, Yang CC, Chi CW, Lee CH, Wong TT: Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system. Mod Pathol; 2005 Jun;18(6):769-78
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  • [Title] Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system.
  • The atypical teratoid/rhabdoid tumor, primary to the central nervous system, is a highly malignant and aggressive neoplasm of infancy and childhood.
  • Although having distinct biological features and clinical outcomes, it is frequently misdiagnosed as primitive neuroectodermal tumor/medulloblastoma.
  • To further distinguish the underlying pathogenesis and to identify biological markers for clinical use, an atypical teratoid/rhabdoid tumor-derived cell line was established and its gene expression pattern analyzed in comparison to the human astrocyte SVG12 cell line and the human DAOY medulloblastoma cell line using a complementary DNA microarray method.
  • The osteopontin gene was found specifically upregulated in atypical teratoid/rhabdoid tumor cells.
  • This specificity was confirmed by immunohistochemistry in pathological sections of tissues from atypical teratoid/rhabdoid tumor patients.
  • Even though the role of osteopontin in the cytopathogenesis of atypical teratoid/rhabdoid tumor still needs to be determined, our data support that overexpressed osteopontin is a potential diagnostic marker for atypical teratoid/rhabdoid tumor.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Gene Expression Profiling. Rhabdoid Tumor / pathology. Sialoglycoproteins / genetics. Teratoma / pathology
  • [MeSH-minor] Cell Line. Cell Line, Tumor. Cluster Analysis. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry. Medulloblastoma / genetics. Medulloblastoma / metabolism. Medulloblastoma / pathology. Nucleic Acid Hybridization / methods. Oligonucleotide Array Sequence Analysis. Osteopontin. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15776015.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin
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54. Parmar H, Hawkins C, Bouffet E, Rutka J, Shroff M: Imaging findings in primary intracranial atypical teratoid/rhabdoid tumors. Pediatr Radiol; 2006 Feb;36(2):126-32
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  • [Title] Imaging findings in primary intracranial atypical teratoid/rhabdoid tumors.
  • BACKGROUND: Intracranial atypical teratoid/rhabdoid tumors (AT/RT) are rare and extremely aggressive neoplasms seen primarily in childhood.
  • However, correct diagnosis of AT/RT is important because these tumors have a markedly different clinical prognosis and require more aggressive therapy.
  • OBJECTIVE: To determine the imaging features of AT/RT.
  • MATERIALS AND METHODS: We retrospectively analyzed imaging findings in 11 patients with primary intracranial AT/RT presenting over a period of 5 years.
  • Immunohistochemical staining for INI-1 (BAF47) was performed on all tumors.
  • Six tumors were located in the posterior fossa and five in the supratentorial compartment.
  • The tumors showed a hyperdense solid component (64%) that showed moderate to marked enhancement with contrast medium.
  • All tumors were large in size (average 4.2 x 3.7 cm), and there was a tendency for calcification (36%), hemorrhage (46%), necrosis (46%) and perifocal edema (100%).
  • There was also a high tendency for subarachnoid dissemination, with five patients (46%) demonstrating brain and/or spinal metastasis.
  • At the time of recurrence, all these patients showed extensive leptomeningeal spread of the disease in both intracranial and intraspinal compartments.
  • CONCLUSION: There are no specific imaging features for intracranial AT/RT.
  • But a high tendency toward large size, a hyperdense solid component on CT scan with calcification, hemorrhage, necrosis and subarachnoid spread suggest that this tumor should be considered in the differential diagnosis of large pediatric intracranial tumors.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroectodermal Tumors, Primitive / diagnosis. Rhabdoid Tumor / diagnosis. Skull / pathology. Teratoma / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16341528.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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55. Yano S, Hida K, Kobayashi H, Iwasaki Y: Successful multimodal therapies for a primary atypical teratoid/rhabdoid tumor in the cervical spine. Pediatr Neurosurg; 2008;44(5):406-13
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  • [Title] Successful multimodal therapies for a primary atypical teratoid/rhabdoid tumor in the cervical spine.
  • Atypical teratoid/rhabdoid tumor (AT/RT) occurring in the central nervous system is a high-grade malignant tumor, and its prognosis is poor for patients younger than 3 years of age.
  • In this article, we present a case of infant AT/RT in the cervical spine and its successful treatment by intensive chemotherapy.
  • MRI revealed a large, intradural mass in the cervical spine.Total surgical resection was performed, and the specimen was diagnosed as AT/RT.
  • At the age of nearly 3 years, she received radiation therapy to the local tumor bed and craniospinal axis.
  • The success of this treatment for the patient was that we could prevent tumor recurrence until she was able to receive radiotherapy.
  • [MeSH-major] Cervical Vertebrae / pathology. Rhabdoid Tumor / drug therapy. Spinal Neoplasms / drug therapy. Teratoma / drug therapy

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18703889.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 22
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56. Shalaby T, von Bueren AO, Hürlimann ML, Fiaschetti G, Castelletti D, Masayuki T, Nagasawa K, Arcaro A, Jelesarov I, Shin-ya K, Grotzer M: Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. Mol Cancer Ther; 2010 Jan;9(1):167-79
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  • [Title] Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.
  • We investigated here the effects of S2T1-6OTD, a novel telomestatin derivative that is synthesized to target G-quadruplex-forming DNA sequences, on a representative panel of human medulloblastoma (MB) and atypical teratoid/rhabdoid (AT/RT) childhood brain cancer cell lines.
  • In remarkable contrast to control cells, short-term (72-hour) treatment with S2T1-6OTD resulted in a dose- and time-dependent antiproliferative effect in all MB and AT/RT brain tumor cell lines tested (IC(50), 0.25-0.39 micromol/L).
  • Long-term treatment (5 weeks) with nontoxic concentrations of S2T1-6OTD resulted in a time-dependent (mainly c-Myc-dependent) telomere shortening.
  • On in vivo animal testing, S2T1-6OTD may well represent a novel therapeutic strategy for childhood brain tumors.
  • [MeSH-major] G-Quadruplexes / drug effects. Medulloblastoma / metabolism. Medulloblastoma / pathology. Oxazoles / pharmacology. Proto-Oncogene Proteins c-myc / metabolism. Rhabdoid Tumor / pathology. Teratoma / pathology
  • [MeSH-minor] Apoptosis / drug effects. Base Sequence. Cell Cycle / drug effects. Cell Line, Tumor. Cell Proliferation / drug effects. Cell Survival / drug effects. Cyclin-Dependent Kinase 2 / metabolism. Dose-Response Relationship, Drug. Down-Regulation / drug effects. Drug Screening Assays, Antitumor. Humans. Promoter Regions, Genetic / genetics. Protein Binding / drug effects. RNA, Messenger / genetics. RNA, Messenger / metabolism. Telomerase / genetics. Telomerase / metabolism. Time Factors


57. Sasaki A, Kurihara H, Ishiuchi S, Hirato J, Saito N, Nakazato Y: Pediatric embryonal tumor of the cerebellum with rhabdoid cells and novel intracytoplasmic inclusions: distinction from atypical teratoid/rhabdoid tumor. Acta Neuropathol; 2005 Jul;110(1):69-76
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  • [Title] Pediatric embryonal tumor of the cerebellum with rhabdoid cells and novel intracytoplasmic inclusions: distinction from atypical teratoid/rhabdoid tumor.
  • We report a case of embryonal tumor with novel inclusion bodies occurring in the cerebellum of a 12-year-old girl.
  • The tumor was histopathologically composed of small undifferentiated cells intermingled with a small number of rhabdoid cells, which had an ultrastructural feature of intermediate filament whorls.
  • Immunohistochemically, the neoplasm showed a polyphenotype, including glial fibrillary acidic protein (GFAP), S-100, synaptophysin, chromogranin A, cytokeratin, vimentin, smooth muscle actin, and desmin.
  • In conclusion, this tumor was differentiated from atypical teratoid/rhabdoid tumor by the absence of EMA and the presence of INI1 mRNA and protein, and diagnosed as an unclassified, embryonal tumor.
  • Eosinophilic, granulovesicular inclusions of the tumor cells are novel cytoplasmic inclusions in the brain tumor.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Chromosomal Proteins, Non-Histone. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Microscopy, Electron, Transmission. Mucin-1 / metabolism. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Rhabdoid Tumor / pathology. Teratoma / pathology. Transcription Factors

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  • (PMID = 15965700.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Mucin-1; 0 / RNA, Messenger; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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58. Baker-Jarvis J, Riddle B, Janezic MD: Dielectric polarization evolution equations and relaxation times. Phys Rev E Stat Nonlin Soft Matter Phys; 2007 May;75(5 Pt 2):056612

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  • [Title] Dielectric polarization evolution equations and relaxation times.
  • In this paper we develop dielectric polarization evolution equations, and the resulting frequency-domain expressions, and relationships for the resulting frequency dependent relaxation times.
  • We extract relaxation times from dielectric data and give illustrative examples for the harmonic oscillator and derive expressions for the frequency-dependent relaxation times and a time-domain integrodifferential equation for the Cole-Davidson model.

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  • (PMID = 17677191.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Abram ME, Parniak MA: Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain. J Virol; 2005 Sep;79(18):11952-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain.
  • Each of the human immunodeficiency virus type 1 (HIV-1) pol-encoded enzymes, protease (PR), reverse transcriptase (RT), and integrase (IN), is active only as a dimer (or higher-order oligomer in the case of IN), but only RT comprises subunits of different masses.
  • RT is a heterodimer of 66-kDa and 51-kDa subunits.
  • The latter is formed by HIV PR-catalyzed cleavage of p66 during virion maturation, resulting in the removal of the RNase H (RNH) domain of a p66 subunit.
  • In order to study the apparent need for RT heterodimers in the context of the virion, we introduced a variety of mutations in the RT p51-RNH protease cleavage site of an infectious HIV-1 molecular clone.
  • Surprisingly, rather than leading to virions with increased RT p66 content, most of the mutations resulted in significantly attenuated virus that contained greatly decreased levels of RT that in many cases was primarily p51 RT.
  • However, most mutants showed normal levels of the Pr160(gag-pol) precursor polyprotein, suggesting that reduced virion RT arose from proteolytic instability rather than decreased incorporation.
  • Repeated passage of MT-2 cells exposed to mutant viruses led to the appearance of virus with improved replication capacity; these virions contained normally processed RT at near-wild-type levels.
  • These results imply that additional proteolytic processing of RT to the p66/p51 heterodimer is essential to provide proteolytic stability of RT during HIV-1 maturation.

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  • [Cites] J Virol. 1992 Nov;66(11):6361-9 [1404595.001]
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  • (PMID = 16140771.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / P01 GM066671; United States / NIGMS NIH HHS / GM / GM066671
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gene Products, pol; EC 2.7.7.49 / HIV Reverse Transcriptase
  • [Other-IDs] NLM/ PMC1212597
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60. Finkelstein-Shechter T, Gassas A, Mabbott D, Huang A, Bartels U, Tabori U, Janzen L, Hawkins C, Taylor M, Bouffet E: Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy. J Pediatr Hematol Oncol; 2010 Jul;32(5):e182-6
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  • [Title] Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy.
  • PURPOSE: To retrospectively review an institutional experience in managing atypical teratoid/rhabdoid tumors (AT/RT) of the Central Nervous System with high-dose chemotherapy in infants and children less than 4 years old.
  • MATERIALS/METHODS: Eight AT/RT patients were identified during the study period 2003 to 2008.
  • Tumor location was supratentorial in 3 cases, infratentorial in 3 cases, and multifocal in 2 patients.
  • RESULTS: At a median follow-up of 52 months, 4 patients are alive without evidence of tumor.
  • CONCLUSIONS: This experience confirms that a subset of young AT/RT patients may achieve long-term survival with intensive and high-dose chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Rhabdoid Tumor / drug therapy. Teratoma / drug therapy
  • [MeSH-minor] Child, Preschool. Cisplatin / administration & dosage. Combined Modality Therapy. Cranial Irradiation. Cyclophosphamide / administration & dosage. Etoposide / administration & dosage. Female. Humans. Infant. Male. Neoplasm Metastasis. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome. Vincristine / administration & dosage

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  • [ErratumIn] J Pediatr Hematol Oncol. 2011 Jul;33(5):400. Laura, Janzen [corrected to Janzen, Laura]
  • (PMID = 20495479.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin
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61. Al-Zain FT, Rademacher G, Lemcke J, Mutze J, Meier U: [Idiopathic normal-pressure hydrocephalus. Flow measurement of cerebrospinal fluid using phase contrast MRI and its diagnostics importance]. Nervenarzt; 2007 Feb;78(2):181-7
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  • [Transliterated title] Idiopathischer Normaldruckhydrozephalus. Liquorflussmessung mittels Phasenkontrast--RT und ihre diagnostische Bedeutung.
  • PATIENTS AND METHODS: Between January 2003 and April 2005, 61 patients with the Hakim triad of clinical symptoms and dilated ventricular systems underwent the intrathecal infusion test, cerebrospinal tap test, and phase-contrast MRI to measure CSF flow rate in the aqueduct.
  • RESULTS: According to these criteria the patients were classified into groups of 41 with iNPH and 20 with brain atrophy.

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  • (PMID = 17225144.001).
  • [ISSN] 0028-2804
  • [Journal-full-title] Der Nervenarzt
  • [ISO-abbreviation] Nervenarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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62. Tinsa F, Jallouli M, Douira W, Boubaker A, Kchir N, Hassine DB, Boussetta K, Bousnina S: Atypical teratoid/rhabdoid tumor of the spine in a 4-year-old girl. J Child Neurol; 2008 Dec;23(12):1439-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical teratoid/rhabdoid tumor of the spine in a 4-year-old girl.
  • Primary spinal atypical teratoid/rhabdoid tumor is extremely rare.
  • The authors present a case of atypical teratoid/rhabdoid tumor occurring in a 4-year-old girl.
  • [MeSH-major] Rhabdoid Tumor / pathology. Spinal Neoplasms / pathology

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  • (PMID = 19073850.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vimentin
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63. Stabouli S, Sdougka M, Tsitspoulos P, Violaki A, Anagnostopoulos I, Tsonidis Ch, Koliouskas D: Primary atypical teratoid/rhabdoid tumor of the spine in an infant. Hippokratia; 2010 Oct;14(4):286-8
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  • [Title] Primary atypical teratoid/rhabdoid tumor of the spine in an infant.
  • Atypical teratoid/rhabdoid tumor of the spine is a rare pediatric neoplasm with poor prognosis.
  • We report a case of an atypical teratoid/rhabdoid tumor of the cervical spine in a 2-months-old infant.
  • Tumor cells were immunohistochemically positive for epithelial membrane antigen, vimentin, cytokeratins, S-100 protein, and CD57/Leu-7 antigen.
  • We review the literature on spinal malignant rhabdoid tumor and discuss the pathology, treatment, and outcome of these rare neoplasms.

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  • (PMID = 21311641.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC3031327
  • [Keywords] NOTNLM ; atypical teratoid tumor / chemotherapy / chromosome 22q / hydrocephalous / rhabdoid tumor / spine
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64. El-Nabbout B, Shbarou R, Glasier CM, Saad AG: Primary diffuse cerebral leptomeningeal atypical teratoid rhabdoid tumor: report of the first case. J Neurooncol; 2010 Jul;98(3):431-4
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  • [Title] Primary diffuse cerebral leptomeningeal atypical teratoid rhabdoid tumor: report of the first case.
  • Atypical teratoid rhabdoid tumor (AT/RT) of the central nervous system has been recently described as a distinct clinicopathological entity with characteristic morphologic, immunophenotypic and molecular characteristics.
  • AT/RT typically involves the posterior fossa of the pediatric population.
  • Supratentorial AT/RT is exceedingly rare.
  • In this report, we describe a very unusual case of a child who presented with signs and symptoms suggestive of leptomeningitis.
  • However, imaging studies and histologic findings showed plaque-like AT/RT involving the leptomeninges of the cerebrum, cerebellum, and spinal cord.
  • To our knowledge, this is the first case of primary leptomeningeal AT/RT involving the supratentorial leptomeninges.
  • [MeSH-major] Central Nervous System Neoplasms / pathology. Meningeal Neoplasms / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 20020178.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Zimmerman MA, Goumnerova LC, Proctor M, Scott RM, Marcus K, Pomeroy SL, Turner CD, Chi SN, Chordas C, Kieran MW: Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor. J Neurooncol; 2005 Mar;72(1):77-84
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor.
  • Atypical teratoid/rhabdoid tumors (AT/RT) are highly malignant lesions of childhood that carry a very poor prognosis.
  • AT/RT can occur in the central nervous system (CNS AT/RT) and disease in this location carries an even worse prognosis with a median survival of 7 months.
  • In spite of multiple treatment regimens consisting of maximal surgical resection (including second look surgery), radiation therapy (focal and craniospinal), and multi-agent intravenous, oral and intrathecal chemotherapy, with or without high-dose therapy and stem cell rescue, only seven long-term survivors of CNS AT/RT have been reported, all in patients with newly diagnosed disease.
  • We now report on four children, two with newly diagnosed CNS AT/RT and two with progressive disease after multi-agent chemotherapy who are long term survivors (median follow-up of 37 months) using a combination of surgery, radiation therapy, and intensive chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / therapy. Neoplasm Recurrence, Local / therapy. Rhabdoid Tumor / therapy. Teratoma / therapy

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  • (PMID = 15803379.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 37
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66. Krokhin OV, Spicer V: Predicting peptide retention times for proteomics. Curr Protoc Bioinformatics; 2010 Sep;Chapter 13:Unit 13.14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predicting peptide retention times for proteomics.
  • Retention time information can be easily extracted from LC-MS data and it can be used to improve protein identification/characterization procedures.
  • The key to the success of this procedure is the correct retention time prediction based on compositional and structural properties of the separated species.
  • Our Sequence Specific Retention Calculator (SSRCalc) is a Web-based peptide retention prediction that covers the separation selectivity of the most popular RP-HPLC conditions applied in proteomics.

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  • (PMID = 20836075.001).
  • [ISSN] 1934-340X
  • [Journal-full-title] Current protocols in bioinformatics
  • [ISO-abbreviation] Curr Protoc Bioinformatics
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptides
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67. Selvi S, Celiktas C: Compton suppression through rise-time analysis. Appl Radiat Isot; 2007 Nov;65(11):1265-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Compton suppression through rise-time analysis.
  • We studied Compton suppression for 60Co and 137Cs radioisotopes using a signal selection criterion based on contrasting the fall time of the signals composing the photo peak with those composing the Compton continuum.
  • The fall time criterion is employed by using the pulse shape analysis observing the change in the fall times of the gamma-ray pulses.
  • This change is determined by measuring the changes in the rise times related to the fall time of the scintillator and the timing signals related to the fall time of the input signals.
  • We showed that Compton continuum suppression is achieved best via the precise timing adjustment of an analog rise-time analyzer connected to a NaI(Tl) scintillation spectrometer.
  • [MeSH-minor] Scintillation Counting. Spectrometry, Gamma. Time Factors

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  • (PMID = 17703943.001).
  • [ISSN] 0969-8043
  • [Journal-full-title] Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • [ISO-abbreviation] Appl Radiat Isot
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cesium Radioisotopes; 0 / Cobalt Radioisotopes
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68. D'cunja J, Shalaby T, Rivera P, von Büren A, Patti R, Heppner FL, Arcaro A, Rorke-Adams LB, Phillips PC, Grotzer MA: Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells. Eur J Cancer; 2007 Jul;43(10):1581-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells.
  • Central nervous system (CNS) atypical teratoid/rhabdoid tumours (AT/RT) are among the paediatric malignant tumours with the worst prognosis and fatal outcome.
  • In the present study, IGF-IR was expressed in 8/8 primary AT/RT as detected by immunohistochemistry.
  • Moreover, we found IGF-I and IGF-II mRNA in BT-16 CNS AT/RT cells and IGF-II mRNA in BT-12 CNS AT/RT cells, and autophosphorylated IGF-IR in both cell lines, indicating the potential presence of an autocrine/paracrine IGF-I/II/IGF-IR loop in CNS AT/RT.
  • IGF-IR antisense oligonucleotide treatment of human CNS AT/RT cells resulted in significant down-regulation of IGF-IR mRNA and protein expression, induction of apoptosis, and chemosensitisation to doxorubicin and cisplatin.
  • These studies provide evidence for the influence of IGF-IR on cellular responses to chemotherapy and raise the possibility that curability of selected CNS AT/RT may be improved by pharmaceutical strategies directed towards the IGF-IR.
  • [MeSH-major] Apoptosis / drug effects. Central Nervous System Neoplasms / drug therapy. Oligoribonucleotides, Antisense / therapeutic use. Receptor, IGF Type 1 / drug effects. Rhabdoid Tumor / drug therapy. Teratoma / drug therapy

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  • (PMID = 17446062.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Oligoribonucleotides, Antisense; 67763-96-6 / Insulin-Like Growth Factor I; 80168379AG / Doxorubicin; EC 2.7.10.1 / Receptor, IGF Type 1; Q20Q21Q62J / Cisplatin
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69. Lund A, Sagstuen E, Sanderud A, Maruani J: Relaxation-time determination from continuous-microwave saturation of EPR spectra. Radiat Res; 2009 Dec;172(6):753-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relaxation-time determination from continuous-microwave saturation of EPR spectra.
  • This procedure provides a simple alternative method to obtain magnetic relaxation data when the more direct pulse-saturation techniques are not available or are less suitable.
  • The results obtained illustrate that relaxation times comparable to those yielded by various pulse-saturation EPR techniques can be obtained.
  • It appears as a systematic feature that, whenever the pulse EPR data are fitted using bi-exponential functions, the shortest relaxation times obtained are those that correspond best to those measured using the current continuous-wave saturation method.

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  • (PMID = 19929422.001).
  • [ISSN] 1938-5404
  • [Journal-full-title] Radiation research
  • [ISO-abbreviation] Radiat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Wykoff CC, Lam BL, Brathwaite CD, Biegel JA, McKeown CA, Rosenblum MK, Allewelt HB, Sandberg DI: Atypical teratoid/rhabdoid tumor arising from the third cranial nerve. J Neuroophthalmol; 2008 Sep;28(3):207-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical teratoid/rhabdoid tumor arising from the third cranial nerve.
  • An otherwise healthy 6-week-old girl who presented with an isolated left third cranial nerve palsy underwent MRI that revealed an enhancing mass intrinsic to the left third cranial nerve.
  • Rapid enlargement of the lesion over 1 month led to subtotal neurosurgical resection of an atypical teratoid/rhabdoid tumor (AT/RT), a rare, highly aggressive malignancy of infancy closely related histologically to medulloblastoma and primitive neuroectodermal tumor.
  • This is the first report of an AT/RT presenting as an isolated third cranial nerve palsy caused by tumor arising from within the nerve.

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  • [Cites] Childs Nerv Syst. 2001 Sep;17(9):503-11 [11585322.001]
  • [Cites] J Clin Oncol. 2004 Jul 15;22(14):2877-84 [15254056.001]
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  • [Cites] Pediatr Radiol. 2006 Feb;36(2):126-32 [16341528.001]
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  • [Cites] Am J Surg Pathol. 1998 Sep;22(9):1083-92 [9737241.001]
  • (PMID = 18769285.001).
  • [ISSN] 1536-5166
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / P30 EY014801; United States / NCI NIH HHS / CA / R01 CA046274; United States / NCI NIH HHS / CA / CA46274; United States / NCI NIH HHS / CA / R01 CA046274-17A2; United States / NEI NIH HHS / EY / P30-EY014801; United States / NCI NIH HHS / CA / CA046274-17A2
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS110134; NLM/ PMC2839362
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71. Nishihira Y, Tan CF, Hirato J, Yoshimura J, Nishiyama K, Takahashi H, Fujii Y, Takahashi H: A case of congenital supratentorial tumor: atypical teratoid/rhabdoid tumor or primitive neuroectodermal tumor? Neuropathology; 2007 Dec;27(6):551-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of congenital supratentorial tumor: atypical teratoid/rhabdoid tumor or primitive neuroectodermal tumor?
  • Two embryonal CNS tumors, atypical teratoid/rabdoid tumor (AT/RT) and primitive neuroectodermal tumor (PNET), may be confused with each other and misdiagnosed.
  • Here we report an infant with a congenital supratentorial tumor, which was detected by fetal MRI at 37 weeks gestation.
  • On routine histological examination, the tumor was composed mainly of small undifferentiated cells, among which many rhabdoid cells and occasional sickle-shaped embracing cells were observed.
  • Our impression was that the tumor was an atypical example of AT/RT.
  • Immunohistochemically, almost all the tumor cells were strongly positive for vimentin.
  • However, epithelial membrane antigen was notably negative, and most of the tumor cell nuclei were clearly positive for INI1.
  • In addition, many tumor cells were positive for neurofilament protein.
  • There were also occasional small areas containing many tumor cells positive for glial fibrillary acidic protein.
  • Finally, a diagnosis of PNET, with a rhabdoid phenotype and expression of neuronal and glial markers, was made.
  • In the present case, application of INI1 immunostaining was very helpful for distinguishing PNET from AT/RT.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / metabolism. DNA-Binding Proteins / metabolism. Neuroectodermal Tumors, Primitive / pathology. Supratentorial Neoplasms / congenital. Supratentorial Neoplasms / pathology. Teratoma / pathology. Transcription Factors / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Infant, Newborn. Pregnancy. Prenatal Diagnosis. Rhabdoid Tumor / congenital. Rhabdoid Tumor / metabolism. Rhabdoid Tumor / pathology

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  • [ErratumIn] Neuropathology. 2008 Feb;28(1):108
  • (PMID = 18021375.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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72. Lafay-Cousin L, Payne E, Strother D, Chernos J, Chan M, Bernier FP: Goldenhar phenotype in a child with distal 22q11.2 deletion and intracranial atypical teratoid rhabdoid tumor. Am J Med Genet A; 2009 Dec;149A(12):2855-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Goldenhar phenotype in a child with distal 22q11.2 deletion and intracranial atypical teratoid rhabdoid tumor.
  • Here we report on an infant diagnosed with Goldenhar syndrome (GS) phenotype who developed an atypical teratoid rhabdoid tumor (AT/RT) of the brain due to a distal deletion of the chromosome 22q11.2 region encompassing the INI1/SMARCB1 tumor suppressor.
  • [MeSH-major] Brain Neoplasms / complications. Chromosome Deletion. Chromosomes, Human, Pair 22 / genetics. Goldenhar Syndrome / complications. Rhabdoid Tumor / complications. Teratoma / complications

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  • [CommentIn] Am J Med Genet A. 2011 Feb;155A(2):458 [21271674.001]
  • (PMID = 19938088.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Gattenlöhner S, Bonengel M, Müller-Hermelink HK: [Optimized RT-PCR based detection of specific genetic abnormalities within malignant hematopoietic disorders]. Pathologe; 2006 May;27(3):182-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Optimized RT-PCR based detection of specific genetic abnormalities within malignant hematopoietic disorders].
  • [Transliterated title] Maligne hämatopoetische Systemerkrankungen : Optimierter RT-PCR-basierter Nachweis spezifischer genetischer Abnormalitäten.
  • The moleculargenetic detection of specific genetic abnormalities within malignant hematopoietic disorders is an important diagnostic tool with relevance for the differential diagnosis, therapy and prognosis.According to a modified and optimized RT-PCR based technique native bone marrow aspirates and peripheral blood samples of 183 patients were investigated for the presence of specific genetic abnormalities.
  • The hereby described method is a simple, specific and reliable technique for the rapid moleculargenetic detection of specific genetic abnormalities within malignant hematopoietic disorders with implication for the diagnosis/differential diagnosis, prognosis and therapy.

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  • (PMID = 15703887.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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74. Akber SF: Water proton relaxation times of pathological tissues. Physiol Chem Phys Med NMR; 2008;40:1-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Water proton relaxation times of pathological tissues.
  • The spin-lattice relaxation time (T1) and spin-spin relaxation time (T2) of pathological human and animal tissues are archived to update those already published.
  • The mechanisms for water proton relaxation times of pathological tissues and the dissimilarities in relaxation times between normal and pathological tissues are also briefly reviewed.

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  • (PMID = 20070038.001).
  • [ISSN] 0748-6642
  • [Journal-full-title] Physiological chemistry and physics and medical NMR
  • [ISO-abbreviation] Physiol Chem Phys Med NMR
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ions; 0 / Proteins; 0 / Protons; 059QF0KO0R / Water
  • [Number-of-references] 228
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75. Zatevakhin II, Shipovskiĭ VN, Zolkin VN, Nechaev AI, Piliposian EA: Rheolytic thrombectomy: possibilities and first results. Angiol Sosud Khir; 2008;14(1):43-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rheolytic thrombectomy: possibilities and first results.
  • The present study was undertaken to investigate the possibilities of using the method of rheolytic thrombectomy (hereinafter referred to as RTE) in surgical practice, and to assess its immediate outcomes in treatment of thromboses of arteries and veins of the lower extremities, as well as transjugular intrahepatic portosystemic shunts (hereinafter referred to as TIPS).
  • We have gained experience in carrying out a total of 33 rheolytic thrombectomies with the help of the system JET 9000 (R) using the Xpeedior catheter in a total of thirty-one 43-to-87-year-old patients.
  • Nineteen patients underwent a total of 13 balloon angioplasties (BA), 4 stenting interventions, and 2 regional thrombolytic procedures.
  • [MeSH-major] Lower Extremity / blood supply. Lower Extremity / surgery. Thrombectomy / methods. Venous Thrombosis / surgery

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  • (PMID = 19156029.001).
  • [ISSN] 1027-6661
  • [Journal-full-title] Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery
  • [ISO-abbreviation] Angiol Sosud Khir
  • [Language] eng; rus
  • [Publication-type] Journal Article
  • [Publication-country] Russia (Federation)
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76. Doi M, Yamaue T: Variational bounds for the relaxation times of swelling gels. Phys Rev E Stat Nonlin Soft Matter Phys; 2005 Apr;71(4 Pt 1):041404

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Variational bounds for the relaxation times of swelling gels.
  • Variational bounds are found for the relaxation times of a gel of general shape swelling in a solvent based on the stress-diffusion coupling model.
  • It is shown that in the case of free swelling, the longest relaxation time is inversely proportional to the osmotic modulus K in the limit of K-->0 and K-->infinity .
  • This indicates that the relaxation time diverges at the point of K=0 .

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  • (PMID = 15903668.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Fujita M, Sato M, Nakamura M, Kudo K, Nagasaka T, Mizuno M, Amano E, Okamoto Y, Hotta Y, Hatano H, Nakahara N, Wakabayashi T, Yoshida J: Multicentric atypical teratoid/rhabdoid tumors occurring in the eye and fourth ventricle of an infant: case report. J Neurosurg; 2005 Apr;102(3 Suppl):299-302
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicentric atypical teratoid/rhabdoid tumors occurring in the eye and fourth ventricle of an infant: case report.
  • Atypical teratoid/rhabdoid tumors (AT/RTs) are aggressive malignant tumors found in infants and young children.
  • The tumor is characterized by the presence of a rhabdoid cell component in all cases, but the histological origin is still unclear.
  • Recently, germline mutation of the hSNF5/INI1 gene has been reported in association with AT/RTs.
  • The authors report a rare case of an intraocular AT/RT followed by a fourth ventricular tumor.
  • The results of immunohistochemical studies of the surgical specimens revealed the presence of an AT/RT and from this finding the neural origin was inferred.
  • The immunohistochemical relationship between rhabdoid cells and the neurogenic zone, which has not been described in AT/RTs, is of great interest in view of the nature of rhabdoid cells.
  • [MeSH-major] Cerebral Ventricle Neoplasms / surgery. Eye Neoplasms / surgery. Fourth Ventricle / surgery. Neoplasms, Multiple Primary / surgery. Rhabdoid Tumor / surgery. Teratoma / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Bone Marrow Purging. Chemotherapy, Adjuvant. Chromosomal Proteins, Non-Histone. Codon / genetics. Combined Modality Therapy. DNA-Binding Proteins / genetics. Disease Progression. Eye / pathology. Eye Enucleation. Follow-Up Studies. Germ-Line Mutation. Humans. Infant, Newborn. Intermediate Filament Proteins / genetics. Magnetic Resonance Imaging. Male. Microscopy, Acoustic. Mutation, Missense / genetics. Nerve Tissue Proteins / genetics. Nestin. RNA-Binding Proteins / genetics. Stem Cell Transplantation. Transcription Factors

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  • (PMID = 15881754.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / Codon; 0 / DNA-Binding Proteins; 0 / Intermediate Filament Proteins; 0 / MSI1 protein, human; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / RNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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78. Zhang R, Monsma F: The importance of drug-target residence time. Curr Opin Drug Discov Devel; 2009 Jul;12(4):488-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The importance of drug-target residence time.
  • The importance of kinetics in drug-target interactions, and particularly the residence time of a drug with its target, is increasingly recognized to play a pivotal role in determining both the efficacy and toxicity of a drug.
  • Drug residence time can often be demonstrated to be a key differentiating factor between drugs that act upon a common target.
  • Drug-target residence time can result in either favorable or unfavorable outcomes, and the use of such information could lead to the more efficient design of best-in-class drugs.
  • This review highlights several key concepts and observations related to drug-target residence time, and suggests the use of a kinetics-perceptive and energetics-informed approach to address the challenges facing current drug discovery efforts.
  • [MeSH-minor] Dose-Response Relationship, Drug. Models, Biological. Protein Binding. Structure-Activity Relationship. Time Factors

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  • (PMID = 19562645.001).
  • [ISSN] 2040-3437
  • [Journal-full-title] Current opinion in drug discovery & development
  • [ISO-abbreviation] Curr Opin Drug Discov Devel
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
  • [Number-of-references] 55
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79. Kegel WK, Breed D, Elsesser M, Pine DJ: Formation of anisotropic polymer colloids by disparate relaxation times. Langmuir; 2006 Aug 15;22(17):7135-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Formation of anisotropic polymer colloids by disparate relaxation times.
  • We show that coupling between a fast and a slow relaxation time causes the spontaneous formation of protrusions in colloids made of cross-linked polymers.
  • The volume of the protrusions can be controlled by adjusting the ratio between the relaxation times.

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  • (PMID = 16893204.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Micyus NJ, Seeley SK, Seeley JV: Method for reducing the ambiguity of comprehensive two-dimensional chromatography retention times. J Chromatogr A; 2005 Sep 9;1086(1-2):171-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Method for reducing the ambiguity of comprehensive two-dimensional chromatography retention times.
  • This process can only be done unambiguously when the range of secondary retention times is less than the modulation period.
  • However, complex samples often produce wider ranges of secondary retention times.
  • Peaks with retention times that exceed the modulation period are said to be "wrapped-around".
  • A simple algorithm has been developed that determines absolute retention times when wrap-around occurs.
  • Retention shifts along the secondary axis are used to determine absolute retention times.
  • [MeSH-minor] Algorithms. Time Factors

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  • (PMID = 16130670.001).
  • [ISSN] 0021-9673
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies
  • [Publication-country] Netherlands
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81. Sun W, Zhang L, Yang R, Shao C, Zhang Z, Gao Y: Improving peptide identification using an empirical peptide retention time database. Rapid Commun Mass Spectrom; 2009 Jan;23(1):109-18

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improving peptide identification using an empirical peptide retention time database.
  • Peptide retention time (RT) is independent of tandem mass spectrometry (MS/MS) parameters and can be combined with MS/MS information to enhance peptide identification.
  • In this paper, we utilized peptide empirical RT and MS/MS for peptide identification.
  • This new approach resulted in the construction of an Empirical Peptide Retention Time Database (EPRTD) based on peptides showing a false-positive rate (FPR) <or=1%, detected in several liquid chromatography (LC)/MS/MS analyses.
  • In subsequent experiments, the RT of peptides with FPR >1% was compared with empirical data derived from the EPRTD.
  • If the experimental RT was within a specified time range of the empirical value, the corresponding MS/MS spectra were accepted as positive.
  • This approach is suitable for large-scale clinical proteomics research, in which tens of LC/MS/MS analyses are run for different samples with similar components.
  • [MeSH-minor] Animals. Chromatography, Liquid. Databases, Protein. Humans. Proteomics / methods. Time Factors. Yeasts

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  • [Copyright] (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 19065623.001).
  • [ISSN] 0951-4198
  • [Journal-full-title] Rapid communications in mass spectrometry : RCM
  • [ISO-abbreviation] Rapid Commun. Mass Spectrom.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Peptides
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82. Giuggioli L, Parris PE, Kenkre VM: Variational formula for the relaxation time in the Boltzmann equation. J Phys Chem B; 2006 Sep 28;110(38):18921-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Variational formula for the relaxation time in the Boltzmann equation.
  • The relaxation time approximation (RTA) is commonly employed in nonequilibrium statistical mechanics to approximate solutions to the Boltzmann equation in terms of an exponential relaxation to equilibrium.
  • Despite its common use, the RTA suffers from the drawback that relaxation times commonly employed are independent of initial conditions.
  • We derive a variational principle for solutions to the Boltzmann equation, which allows us to extend the standard RTA using relaxation times that depend on the initial distribution.
  • Tests of the approach on a calculation of the mobility for a one-dimensional (1D) tight-binding band indicate that our analysis typically provides a better approximation than the standard RTA.

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  • (PMID = 16986884.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Marks LB, Yu X, Prosnitz RG, Zhou SM, Hardenbergh PH, Blazing M, Hollis D, Lind P, Tisch A, Wong TZ, Borges-Neto S: The incidence and functional consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys; 2005 Sep 1;63(1):214-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The incidence and functional consequences of RT-associated cardiac perfusion defects.
  • PURPOSE: Radiation therapy (RT) for left-sided breast cancer has been associated with cardiac dysfunction.
  • We herein assess the temporal nature and volume dependence of RT-induced left ventricular perfusion defects and whether these perfusion defects are related to changes in cardiac wall motion or alterations in ejection fraction.
  • METHODS: From 1998 to 2001, 114 patients were enrolled onto an IRB-approved prospective clinical study to assess changes in regional and global cardiac function after RT for left-sided breast cancer.
  • Post-RT perfusion scans were compared with the pre-RT studies to assess for RT-induced perfusion defects as well as functional changes in wall motion and ejection fraction.
  • Two-tailed Fisher's exact test and the Cochran-Armitage test for linear trends were used for statistical analysis.
  • RESULTS: The incidence of new perfusion defects 6, 12, 18, and 24 months after RT was 27%, 29%, 38%, and 42%, respectively.
  • New defects occurred in approximately 10% to 20% and 50% to 60% of patients with less than 5%, and greater than 5%, of their left ventricle included within the RT fields, respectively (p = 0.33 to 0.00008).
  • The rates of wall motion abnormalities in patients with and without perfusion defects were 12% to 40% versus 0% to 9%, respectively; p values were 0.007 to 0.16, depending on the post-RT interval.
  • CONCLUSIONS: Radiation therapy causes volume-dependent perfusion defects in approximately 40% of patients within 2 years of RT.
  • Additional study is necessary to better define the long-term functional consequences of RT-induced perfusion defects.

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  • [CommentIn] Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1287; author reply 1287-8 [16504767.001]
  • (PMID = 16111592.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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84. Ferreira Junior OC, Ferreira C, Riedel M, Widolin MR, Barbosa-Júnior A, HIV Rapid Test Study Group: Evaluation of rapid tests for anti-HIV detection in Brazil. AIDS; 2005 Oct;19 Suppl 4:S70-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of rapid tests for anti-HIV detection in Brazil.
  • OBJECTIVES: This assessment in Brazil was to evaluate the performance of commercially available HIV rapid test (RT) against the gold standard testing and to establish a highly sensitive and specific RT algorithm for HIV diagnosis.
  • METHODS: An evaluation of seven commercially available RT to compare their performance against the gold standard tests for Brazil.
  • RESULTS: For the seven RT the clinical sensitivity ranged from 97.74 to 100% and clinical specificity from 99.43 to 100%.
  • However, only four RT were considered acceptable after full evaluation.
  • Two RT had the same performance on the seroconversions panels as the EIA.
  • The operational assay performance evaluation for the RT indicated that Hexagon and Capillus could not be classified as simple assays.
  • CONCLUSION: We have provided evidence that RT assays can perform equally or better than EIA for the detection of HIV antibodies.
  • The simplicity and rapidity of the RT warrants its utilization in an algorithm for a rapid diagnosis of HIV infection.
  • [MeSH-minor] Algorithms. Blotting, Western. Humans. Immunoenzyme Techniques. Prospective Studies. Quality Control. Reagent Kits, Diagnostic / standards. Reproducibility of Results. Sensitivity and Specificity. Time Factors

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  • (PMID = 16249658.001).
  • [ISSN] 0269-9370
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Reagent Kits, Diagnostic
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85. Hayashi K, Sugawara J, Aizawa K, Komine H, Yoshizawa M, Nakamura M, Yokoi T: Arterial elastic property in young endurance and resistance-trained women. Eur J Appl Physiol; 2008 Nov;104(5):763-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Arterial elastic property in young endurance and resistance-trained women.
  • In men, regular aerobic exercise increases central arterial elasticity, but it is decreased by resistance training.
  • We determined the relation between the type of exercise training and arterial elasticity in healthy young women: 26 healthy young women who were sedentary (CO, n = 9), endurance-trained (ET, n = 9), and resistance-trained (RT, n = 8) groups.
  • The VO(2max) in the ET groups was higher than in the CO and RT groups.
  • Both 1RM were higher in the RT groups than in the CO and ET groups.
  • No significant difference was found in the carotid artery compliance and distensibility coefficient among the ET, RT, and CO groups.
  • [MeSH-major] Carotid Artery, Common / physiology. Physical Endurance. Resistance Training

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  • (PMID = 18649085.001).
  • [ISSN] 1439-6319
  • [Journal-full-title] European journal of applied physiology
  • [ISO-abbreviation] Eur. J. Appl. Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Endothelin-1; X4W3ENH1CV / Norepinephrine
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86. Alvarez K, Deval J, Selmi B, Barral K, Boretto J, Guerreiro C, Mulard L, Sarfati R, Canard B: Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance. Nucleosides Nucleotides Nucleic Acids; 2005;24(5-7):419-21
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  • [Title] Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance.
  • Alpha-boranophosphates suppress RT-mediated resistance when the catalytic rate of incorporation (kpol) of the analogue 5'-triphosphate is responsable for drug resistance, such as in the case of K65R mutant and ddNTPs, and Q151M toward AZTTP and ddNTPs.
  • Moreover, the presence of the borano (BH3-) group renders the incorporation of the analogue independent from amino-acid substitutions in RT.
  • To our knowledge, this is the first example of rescue of polymerase activity by means of a nucleotide analogue.
  • [MeSH-major] Anti-HIV Agents / chemical synthesis. Boron / chemistry. Boron Compounds / pharmacology. Drug Resistance, Viral

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  • [ErratumIn] Nucleosides Nucleotides Nucleic Acids. 2006;25(3):351-2
  • (PMID = 16247962.001).
  • [ISSN] 1525-7770
  • [Journal-full-title] Nucleosides, nucleotides & nucleic acids
  • [ISO-abbreviation] Nucleosides Nucleotides Nucleic Acids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Anti-HIV Agents; 0 / Boron Compounds; 0 / Phosphates; EC 2.7.7.49 / HIV Reverse Transcriptase; N9E3X5056Q / Boron; S88TT14065 / Oxygen
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87. Bengtsson M, Hemberg M, Rorsman P, Ståhlberg A: Quantification of mRNA in single cells and modelling of RT-qPCR induced noise. BMC Mol Biol; 2008 Jul 17;9:63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quantification of mRNA in single cells and modelling of RT-qPCR induced noise.
  • Quantitative reverse transcription PCR (RT-qPCR) is the most accessible method which provides sufficiently accurate measurements of mRNA in single cells.
  • RESULTS: Low concentration of guanidine thiocyanate was used to fully lyse single pancreatic beta-cells followed by RT-qPCR without the need for purification.
  • Importantly, the model allows us to determine the RT efficiency without using artificial RNA as a standard.
  • CONCLUSION: Noise in single-cell RT-qPCR is insignificant compared to biological cell-to-cell variation in mRNA levels for medium and high abundance transcripts.
  • To minimize the technical noise in single-cell RT-qPCR, the mRNA should be analyzed with a single RT reaction, and a single qPCR reaction per gene.

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  • (PMID = 18631407.001).
  • [ISSN] 1471-2199
  • [Journal-full-title] BMC molecular biology
  • [ISO-abbreviation] BMC Mol. Biol.
  • [Language] ENG
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2483285
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88. Hu CS: RT-ABCDE strategy for management and prevention of human diseases. Chin J Integr Med; 2008 Jun;14(2):147-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] RT-ABCDE strategy for management and prevention of human diseases.
  • In this article, the authors summarized the RT-ABCDE strategy for the management and prevention of human diseases, which includes ReTro-ABCDE (Examination regularity, Disease and risk factor control, Changing lifestyle and reducing pathways of infection and spread, Biochemical and Antagonistic index control and therapeutic treatment as well as RT--Routine and Right Treatment).
  • The RT-ABCDE strategy, a novel concept and an essential method, should be a routine strategy for disease control and prevention.

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  • (PMID = 18219448.001).
  • [ISSN] 1672-0415
  • [Journal-full-title] Chinese journal of integrative medicine
  • [ISO-abbreviation] Chin J Integr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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89. Allain JP, Lee H: Rapid tests for detection of viral markers in blood transfusion. Expert Rev Mol Diagn; 2005 Jan;5(1):31-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid tests for detection of viral markers in blood transfusion.
  • Since the early 1990s, rapid tests have been available for detection of HIV infection.
  • In addition, rapid tests for anti-HIV, hepatitis B surface antigen and antihepatitis C virus have been used for blood screening in many resource-poor areas to save resources and overcome lack of funding, equipment and electrical supply.
  • The performance of rapid tests varies widely but some have sensitivity and specificity levels that meet standards established by enzyme immunoassays for anti-HIV.
  • Compared with genomic detection of hepatitis B virus, hepatitis B surface antigen rapid tests and enzyme immunoassays have insufficient sensitivity.
  • Anti-hepatitis C virus rapid tests detect chronically infected individuals who are viremic, however, further studies are required to fully assess their performance.
  • In settings where few blood donations are collected and equipment is unavailable, rapid tests provide a flexible, technically undemanding and relatively inexpensive approach to ensuring a safer blood supply.
  • When utilized for predonation screening in areas of high endemicity of viral markers, rapid tests provide the means to limit blood bag wasting, store only clinically usable blood and inform and counsel deferred donors.
  • As a means of achieving a safe blood supply, rapid tests for viral markers and nucleic acid testing have a place next to classic enzyme immunoassays in the definition of strategies that are adapted to a setting's epidemiology, the size and type of donor base, equipment, staff training and resources.

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  • (PMID = 15723590.001).
  • [ISSN] 1473-7159
  • [Journal-full-title] Expert review of molecular diagnostics
  • [ISO-abbreviation] Expert Rev. Mol. Diagn.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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90. Searle KR, Vandervelde T, Hobbs NT, Shipley LA, Wunder BA: Spatial context influences patch residence time in foraging hierarchies. Oecologia; 2006 Jul;148(4):710-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spatial context influences patch residence time in foraging hierarchies.
  • We examined the effects of the spatial context surrounding a patch on the amount of time herbivores resided in the patch.
  • We developed a set of competing models predicting residence time as a function of the mass of plants contained in a patch and the distance between patches and examined the strength of evidence in our observations for these models.
  • Models that included patch mass and inter-patch distance as independent variables successfully predicted observed residence times (bears: r (2)=0.67-0.76 and mule deer: r (2)=0.33-0.55).
  • Residence times of grizzly bears (Ursus arctos) and mule deer (Odocoileus hemionus) responded to the spatial context surrounding a patch.
  • Evidence ratios of Akaike weights demonstrated that models containing effects of higher levels in the hierarchy on residence time at lower levels received up to 34 times more support in the data than models that failed to consider the higher level context for grizzly bears and up to 48 times more support for mule deer.
  • We conclude that foraging by large herbivores is influenced by more than one level of heterogeneity in patch hierarchies and that simple empirical models offer a viable alternative to optimal foraging models for the prediction of patch residence times.
  • [MeSH-minor] Animals. Female. Male. Time Factors

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  • (PMID = 16705439.001).
  • [ISSN] 0029-8549
  • [Journal-full-title] Oecologia
  • [ISO-abbreviation] Oecologia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
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91. Hämäläinen J, Leppänen PH, Torppa M, Müller K, Lyytinen H: Detection of sound rise time by adults with dyslexia. Brain Lang; 2005 Jul;94(1):32-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of sound rise time by adults with dyslexia.
  • An important aspect of amplitude modulation cycles are the rise and fall times within the sound.
  • In this study, simplified stimuli equivalent to just one cycle were used and sensitivity to varying rise times was explored.
  • Adult participants with dyslexia or compensated dyslexia and a control group performed a detection task with sound pairs of different rise times.
  • Results showed that the participants with dyslexia differed from the control group in rise time detection and a correlation was found between rise time detection and reading and phonological skills.
  • A subgroup of participants with lower sensitivity to rise time detection characterized by low accuracy in syllable-level phonological skills was found within the dyslexic group.
  • Short stimuli containing only one rise time produced associations with phonological skills and reading, even in a language where the perception of rise time contrasts are not crucial for the signaling of phonemic contrast.
  • [MeSH-minor] Acoustic Stimulation. Adult. Handwriting. Humans. Pattern Recognition, Visual. Phonetics. Reaction Time. Reading

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  • (PMID = 15896381.001).
  • [ISSN] 0093-934X
  • [Journal-full-title] Brain and language
  • [ISO-abbreviation] Brain Lang
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Zhang A, Collinson RL, Hurst RW, Weigele JB: Rheolytic thrombectomy for cerebral sinus thrombosis. Neurocrit Care; 2008;9(1):17-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rheolytic thrombectomy for cerebral sinus thrombosis.
  • INTRODUCTION: Cerebral venous and sinus thrombosis (CVST) is an uncommon cause of stroke that is associated with poor outcomes in high-risk patients who present with stupor or coma, rapidly progressive neurologic deficits or progressive neurologic deficits during therapeutic anticoagulation.
  • METHODS AND RESULTS: We report the rapid treatment of CVST in six patients at high risk for poor outcomes (death or dependency) using rheolytic thrombectomy combined with locally administered low-dose recombinant tissue plasminogen activator (rt-PA), and review the literature on rheolytic thrombectomy for CVST.
  • Two patients experienced partial rethrombosis following rheolytic thrombectomy requiring a second treatment.
  • In 24 cases of rheolytic thrombectomy for CVST that were reviewed from this series and previously published reports, the large majority of patients experienced good to excellent clinical outcomes.
  • Rheolytic thrombectomy combined with locally administered, low-dose recombinant tissue plasminogen activator (rt-PA) is a safe and effective endovascular method to rapidly recanalize the intracranial dural sinuses in high-risk patients with CVST.
  • [MeSH-major] Sinus Thrombosis, Intracranial / drug therapy. Stroke / prevention & control. Thrombectomy / methods. Thrombolytic Therapy / methods

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  • (PMID = 18250978.001).
  • [ISSN] 1541-6933
  • [Journal-full-title] Neurocritical care
  • [ISO-abbreviation] Neurocrit Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrinolytic Agents; EC 3.4.21.68 / Tissue Plasminogen Activator
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93. Lindner B, Schwalger T: Correlations in the sequence of residence times. Phys Rev Lett; 2007 May 25;98(21):210603
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlations in the sequence of residence times.
  • Sequences of residence times (RTs) associated with the escape from metastable states are observed in many fields.
  • Here we study analytically and numerically the correlations among RTs for a bistable stochastic system driven by dichotomous noise.
  • Our theory predicts an oscillatory behavior of the correlations with respect to the lag between RTs.
  • Correlations vanish at all lags if the switching rate matches the hopping rate of the unperturbed system.
  • It is also shown that RT correlations may reveal features of the driving which are not present in the single-RT statistics.

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  • (PMID = 17677758.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Camarasa MJ, Velázquez S, San-Félix A, Pérez-Pérez MJ: TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization. Antivir Chem Chemother; 2005;16(3):147-53
MedlinePlus Health Information. consumer health - HIV/AIDS Medicines.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization.
  • However, viral rebound during therapy, the emergence of HIV drug resistance and the need for long-term treatment modalities are the main causes for the failure of current antiretroviral therapy.
  • Eleven of the approved anti-HIV drugs target the reverse transcriptase (RT).
  • Among the so-called non-nucleoside RT inhibitors (NNRTIs) TSAO derivatives are an unusual class of compounds that exert their unique selectivity for HIV-1 through a specific interaction with the p51 subunit of HIV-1 RT.
  • They are the only NNRTIs for which amino acids at both subunits (p66 and p51) of HIV-1 RT are needed for optimal interaction with the enzyme.

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  • (PMID = 16004078.001).
  • [ISSN] 0956-3202
  • [Journal-full-title] Antiviral chemistry & chemotherapy
  • [ISO-abbreviation] Antivir. Chem. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Organosilicon Compounds; 0 / Reverse Transcriptase Inhibitors; 0 / Spiro Compounds; 0 / t-butyldimethylsilyl compounds; 141781-17-1 / (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine; 142102-79-2 / 1-(2',5'-bis-O-(tert-butyldimethylsilylribofuranosyl)-3-N-methylthymine)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide); EC 2.7.7.49 / HIV Reverse Transcriptase; VC2W18DGKR / Thymidine
  • [Number-of-references] 42
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95. Mudge SM, Icely JD, Newton A: Oxygen depletion in relation to water residence times. J Environ Monit; 2007 Nov;9(11):1194-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxygen depletion in relation to water residence times.
  • The relationship between residence time and oxygen saturation was investigated in a mesotidal lagoon in southern Portugal.
  • The system receives no significant freshwater input during the summer months and has a high evaporation rate.
  • These features enable an estimate of residence time from the salinity differences between ocean water entering the system and lagoon water.
  • The lowest oxygen saturation ( approximately 44%) was measured in the waters with the highest calculated residence times (7 days).
  • There was a significant linear decrease in the oxygen saturation with increasing residence time of approximately 16% per day.

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  • (PMID = 17968445.001).
  • [ISSN] 1464-0325
  • [Journal-full-title] Journal of environmental monitoring : JEM
  • [ISO-abbreviation] J Environ Monit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride; S88TT14065 / Oxygen
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96. Okimoto N, Kibayashi T, Kishimoto M, Yamato K, Kurihara T, Mimura K, Honda Y, Osaki K, Asaoka N: [Testing for Mycoplasma pneumonia using the ImmunoCard Mycoplasma rapid test]. Nihon Kokyuki Gakkai Zasshi; 2007 Mar;45(3):233-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Testing for Mycoplasma pneumonia using the ImmunoCard Mycoplasma rapid test].
  • We evaluated the effectiveness of ImmunoCard Mycoplasma rapid tests in all patients admitted with community-acquired pneumonia (CAP) between January, 2004 and December, 2005.
  • ImmunoCard Mycoplasma rapid tests were performed on the 1st day of admission and we analyzed the frequency of positive cases among CAP cases according to month and age.
  • A total of 82 of 270 (33.7%) and 41 of 257 (16.0%) were positive among CAP cases in 2004 and 2005, respectively.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Enzyme-Linked Immunosorbent Assay. Humans. Middle Aged. Reagent Kits, Diagnostic. Seasons. Serologic Tests / methods

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  • (PMID = 17419434.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Reagent Kits, Diagnostic
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97. Mondal A, Sinha S: Spatiotemporal consequences of relaxation time scales in threshold-coupled systems. Phys Rev E Stat Nonlin Soft Matter Phys; 2006 Feb;73(2 Pt 2):026215

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spatiotemporal consequences of relaxation time scales in threshold-coupled systems.
  • In such systems, the relaxation time allowed between chaotic updates determines the intrinsic driving rate due to the local chaos, and we show that there exists an inverse cascade from fixed spatial profiles to spatiotemporal chaos, as the relaxation time grows shorter.
  • We analyze how this spectrum of spatiotemporal transitions arises from the competing time scales of the local chaos and the propagation of coupling.

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  • (PMID = 16605437.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Holmes K, Williams CM, Chapman EA, Cross MJ: Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design. BMC Res Notes; 2010 Mar 03;3:53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design.
  • However, in many cases good antibodies are not available, and researchers must rely on RT-qPCR to detect knockdown of the mRNA species.
  • FINDINGS: We have observed a phenomenon that gives a disparity between analyzing small interfering RNA (siRNA) efficacy by western blotting of the protein levels and real-time quantitative PCR (RT-qPCR) measurement of mRNA levels.
  • CONCLUSIONS: Our data suggests that for certain mRNAs, degradation of the 3' mRNA fragment resulting from siRNA mediated cleavage is blocked, leaving an mRNA fragment that can act as a template for cDNA synthesis, giving rise to false negative results and the rejection of a valid siRNA duplex.
  • We show that this phenomenon may be avoided by the careful design of RT-qPCR primers for each individual siRNA experiment.

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  • (PMID = 20199660.001).
  • [ISSN] 1756-0500
  • [Journal-full-title] BMC research notes
  • [ISO-abbreviation] BMC Res Notes
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MRC/ G0400383
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2850347
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99. Athale UH, Duckworth J, Odame I, Barr R: Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies. J Pediatr Hematol Oncol; 2009 Sep;31(9):651-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies.
  • PURPOSE: Therapy for central nervous system (CNS) atypical teratoid rhabdoid tumor (ATRT) is controversial.
  • RESULTS: The median OS for patients treated with multiagent chemotherapy (n=79) was 17.3 months (range, 1.5-93 mo); unrelated to age at diagnosis, sex, tumor site, and extent of resection.
  • Patients (n=30) treated with intrathecal (IT) chemotherapy had significantly higher 2-year OS [64% (95% confidence interval, 46.5-82.0) vs. 17.3% (95% confidence interval, 5.4-29.3); P<0.0001] and lower prevalence of distant CNS metastasis compared with those without IT therapy (n=49) (20% vs. 59.2%; P=0.001).
  • CONCLUSIONS: Despite dismal OS, multimodal therapy can induce remission even in metastatic CNS ATRT with partial resection.
  • [MeSH-major] Brain Neoplasms / epidemiology. Rhabdoid Tumor / epidemiology. Teratoma / epidemiology

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  • (PMID = 19707161.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Meta-Analysis
  • [Publication-country] United States
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin
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100. Hagiwara T, Saito S, Ujiie Y, Imai K, Kakuta M, Kadota K, Terada T, Sumikoshi K, Shimizu K, Nishi T: HPLC Retention time prediction for metabolome analysi. Bioinformation; 2010;5(6):255-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HPLC Retention time prediction for metabolome analysi.
  • Liquid Chromatography Time-of-Flight Mass Spectrometry (LC-TOF-MS) is widely used for profiling metabolite compounds.
  • LC-TOF-MS is a chemical analysis technique that combines the physical separation capabilities of high-pressure liquid chromatography (HPLC) with the mass analysis capabilities of Time-of-Flight Mass Spectrometry (TOF-MS) which utilizes the difference in the flight time of ions due to difference in the mass-to-charge ratio.
  • Contemporaneously analyzed reference standards are commonly required for mass spectral matching and retention time matching, but there are far fewer reference standards than there are compounds in the organism.
  • We therefore developed a retention time prediction method for HPLC to improve the accuracy of identification of metabolite compounds.
  • This method uses a combination of Support Vector Regression and Multiple Linear Regression adaptively to the measured retention time.
  • We achieved a strong correlation (correlation coefficient = 0.974) between measured and predicted retention times for our experimental data.

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  • (PMID = 21364827.001).
  • [ISSN] 0973-2063
  • [Journal-full-title] Bioinformation
  • [ISO-abbreviation] Bioinformation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
  • [Other-IDs] NLM/ PMC3055703
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