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2. Duffy S, Jackson TL, Lansdown M, Philips K, Wells M, Pollard S, Clack G, Cuzick J, Coibion M, Bianco AR: The ATAC adjuvant breast cancer trial in postmenopausal women: baseline endometrial subprotocol data. BJOG; 2003 Dec;110(12):1099-106
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two hundred and seventy-two women had a hysteroscopy before they commenced trial medication.
  • MAIN OUTCOME MEASURES: To assess the demographic characteristics of women entering the endometrial subprotocol and their hysteroscopic and histological findings before commencing trial medication.
  • RESULTS: At hysteroscopy, there was a diagnosis of endometrial polyps in 34 women (13%), fibroids in 16 women (6%) and one case of suspicious endometrium, which was confirmed as a polyp on histology.
  • Final histology found the prevalence of endometrial diagnostic categories as follows: 123 inactive endometrium (46%), 20 benign polyps (7%), 17 secretory endometrium (6%), 7 proliferative endometrium (3%), 3 atypical hyperplasia (2 in a polyp), 1 simple hyperplasia (in a polyp) and 1 fibroid.
  • In this baseline group, 82% (219/268) of women had a normal endometrial cavity; 18% (49/268) had endometrial activity (proliferative or secretory endometrium in 9%) or an intracavity abnormality (hyperplasia, polyps and a fibroid in 9%).
  • The appearance of a polyp hysteroscopically in this group was not proven histologically in approximately 40% of cases.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Nitriles / therapeutic use. Tamoxifen / therapeutic use. Triazoles / therapeutic use

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  • (PMID = 14664881.001).
  • [ISSN] 1470-0328
  • [Journal-full-title] BJOG : an international journal of obstetrics and gynaecology
  • [ISO-abbreviation] BJOG
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Nitriles; 0 / Triazoles; 094ZI81Y45 / Tamoxifen; 2Z07MYW1AZ / anastrozole
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3. Golan A, Cohen-Sahar B, Keidar R, Condrea A, Ginath S, Sagiv R: Endometrial polyps: symptomatology, menopausal status and malignancy. Gynecol Obstet Invest; 2010;70(2):107-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patient characteristics included age, menopausal status, presence or absence of symptoms, and use of hormonal medication.
  • Pathologic evaluation disclosed 7 cases of malignancy and 4 cases of atypical hyperplasia among bleeding postmenopausal women (11/263, 4%) and 2 malignancies and 3 cases of hyperplasia with atypia among asymptomatic postmenopausal women (5/378, 1.3%).
  • We recommend removal of any verified endometrial polyp.

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20332644.001).
  • [ISSN] 1423-002X
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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4. Vesna A, Neli B: Benefit and safety of 28-day transdermal estrogen regimen during vaginal hysterectomy (a controlled trial). Maturitas; 2006 Feb 20;53(3):282-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There were no significant differences in occurrence of more thickened endometrium and more significant morphological changes (endometrial polyp, simplex hyperplasia) between the groups.
  • In none of the patients from the both study groups complex hyperplasia, atypical hyperplasia or endometrial carcinoma were observed.
  • [MeSH-major] Estradiol / administration & dosage. Estrogen Replacement Therapy. Estrogens, Conjugated (USP) / administration & dosage. Hysterectomy, Vaginal. Wound Healing / drug effects
  • [MeSH-minor] Administration, Cutaneous. Administration, Intravaginal. Chi-Square Distribution. Endometrium / drug effects. Female. Humans. Middle Aged. Pain, Postoperative. Prolapse. Surgical Wound Infection / prevention & control. Treatment Outcome

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  • (PMID = 16011883.001).
  • [ISSN] 0378-5122
  • [Journal-full-title] Maturitas
  • [ISO-abbreviation] Maturitas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Estrogens, Conjugated (USP); 4TI98Z838E / Estradiol
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5. Lieng M, Qvigstad E, Sandvik L, Jørgensen H, Langebrekke A, Istre O: Hysteroscopic resection of symptomatic and asymptomatic endometrial polyps. J Minim Invasive Gynecol; 2007 Mar-Apr;14(2):189-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY OBJECTIVE: To estimate the occurrence of malignancy and atypical hyperplasia in endometrial polyps in patients with and without symptoms.
  • Age, menopausal status, presence or absence of symptoms, any use of hormonal medication, as well as histologic diagnosis, complications, and eventual repeated surgery were documented (Canadian Task Force classification II-3).
  • PATIENTS: All patients who underwent hysteroscopic resection of an endometrial polyp in our department from January 1, 2001 through March 1, 2005.
  • The prevalence of malignancy or atypical hyperplasia was 3.2% in women with symptoms and 3.9% in those without symptoms.
  • CONCLUSION: The prevalence of malignancy and atypical hyperplasia was found to be relatively high, indicating that symptomatic, as well as asymptomatic, endometrial polyps should be removed.

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  • (PMID = 17368255.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Scrimin F, Wiesenfeld U, Candiotto A, Inglese S, Ronfani L, Guaschino S: Resectoscopic treatment of atypical endometrial polyps in fertile women. Am J Obstet Gynecol; 2008 Oct;199(4):365.e1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resectoscopic treatment of atypical endometrial polyps in fertile women.
  • After 5 years, we found no difference in the 2 groups regarding recurrence of atypical polyps.
  • CONCLUSION: Conservative resectoscopic treatment may be considered in fertile women with atypical polyps if polyp base and surrounding endometrium are benign.
  • [MeSH-minor] Adult. Endometrium / drug effects. Endometrium / pathology. Female. Humans. Levonorgestrel / pharmacology. Middle Aged. Prognosis

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  • (PMID = 18928975.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 5W7SIA7YZW / Levonorgestrel
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