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26. Xiao Z, Xu P: Acetoin metabolism in bacteria. Crit Rev Microbiol; 2007 Apr-Jun;33(2):127-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The excretion of acetoin, which can be diagnosed by the Voges Proskauer test and serves as a microbial classification marker, has its vital physiological meanings to these microbes mainly including avoiding acification, participating in the regulation of NAD/NADH ratio, and storaging carbon.

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  • (PMID = 17558661.001).
  • [ISSN] 1040-841X
  • [Journal-full-title] Critical reviews in microbiology
  • [ISO-abbreviation] Crit. Rev. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA-Binding Proteins; 0 / Repressor Proteins; 0 / catabolite control proteins, bacteria; BG4D34CO2H / Acetoin
  • [Number-of-references] 159
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27. Hishida A, Terakura S, Emi N, Yamamoto K, Murata M, Nishio K, Sekido Y, Niwa T, Hamajima N, Naoe T: GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese. Asian Pac J Cancer Prev; 2005 Jul-Sep;6(3):251-5
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  • We conducted a prevalent case-control study with 51 chronic myelogenous leukemia (CML) cases and 476 controls to investigate the associations between glutathione S-transferase T1 (GSTT1), glutathione S-transferase M1 (GSTM1) deletions, and the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism with risk of chronic myelocytic leukemia in Japanese.
  • Incidence case-control studies with a larger statistical power are now required to confirm our findings.

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  • (PMID = 16235982.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
  • [Chemical-registry-number] EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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28. Lindner HA, Nadeau G, Matte A, Michel G, Ménard R, Cygler M: Site-directed mutagenesis of the active site region in the quinate/shikimate 5-dehydrogenase YdiB of Escherichia coli. J Biol Chem; 2005 Feb 25;280(8):7162-9
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  • Recent YdiB and AroE crystal structures revealed the presence of a NAD(P)-binding and a catalytic domain.

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  • (PMID = 15596430.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Escherichia coli Proteins; 058C04BGYI / Quinic Acid; 30KYC7MIAI / Aspartic Acid; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.1.25 / Shikimate dehydrogenase; K3Z4F929H6 / Lysine
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29. Fukushima T, Wada T, Ohtsu H, Tanaka K: Photoinduced four- and six-electron reduction of mononuclear ruthenium complexes having NAD+ analogous ligands. Dalton Trans; 2010 Dec 28;39(48):11526-34
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  • [Title] Photoinduced four- and six-electron reduction of mononuclear ruthenium complexes having NAD+ analogous ligands.
  • The high efficiency photochemical two-, four- and six-electron reductions of [Ru(bpy)(2)(pbn)](2+) ([1](2+)), [2](2+) and [3](2+), respectively, by taking advantage of proton coupled two electron reduction of NAD(+) analogous type ligands such as pbn opens a general pathway for multi-electron reduction of metal complexes via illumination with visible light.

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  • (PMID = 20830398.001).
  • [ISSN] 1477-9234
  • [Journal-full-title] Dalton transactions (Cambridge, England : 2003)
  • [ISO-abbreviation] Dalton Trans
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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30. Li M, Li Y, Chen J, Wei W, Pan X, Liu J, Liu Q, Leu W, Zhang L, Yang X, Lu J, Wang K: Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor. Biochemistry; 2007 Oct 16;46(41):11451-8
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  • [Title] Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor.
  • Binding of Cu2+ to SAHH resulted in the release of NAD+ cofactors, explaining the loss of the enzymatic activity of SAHH.
  • Further investigation by an ESR probe and computational simulation suggested that Cu2+ could bind at the central channel and interrupt the subunit interactions of SAHH, resulting in a large decrease in affinity to the NAD+ cofactor.
  • [MeSH-major] Adenosylhomocysteinase / antagonists & inhibitors. Adenosylhomocysteinase / chemistry. Copper / pharmacology. NAD / metabolism

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  • (PMID = 17892301.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoenzymes; 0 / Recombinant Proteins; 0U46U6E8UK / NAD; 789U1901C5 / Copper; EC 3.3.1.1 / Adenosylhomocysteinase
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46. Pacher P, Szabó C: Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme. Antioxid Redox Signal; 2005 Nov-Dec;7(11-12):1568-80
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  • PARP activation, on the one hand, depletes its substrate, NAD+, slowing the rate of glycolysis, electron transport, and ATP formation.

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  • [Copyright] Antioxid. Redox Signal. 7, 1568-1580.
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  • (PMID = 16356120.001).
  • [ISSN] 1523-0864
  • [Journal-full-title] Antioxidants & redox signaling
  • [ISO-abbreviation] Antioxid. Redox Signal.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 AA000375-02
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.4.2.30 / Poly(ADP-ribose) Polymerases
  • [Number-of-references] 120
  • [Other-IDs] NLM/ NIHMS38133; NLM/ PMC2228261
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47. Shimizu M, Yuda N, Nakamura T, Tanaka H, Wariishi H: Metabolic regulation at the tricarboxylic acid and glyoxylate cycles of the lignin-degrading basidiomycete Phanerochaete chrysosporium against exogenous addition of vanillin. Proteomics; 2005 Oct;5(15):3919-31
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  • Intracellular proteins were resolved by 2-DE and target protein spots were identified using MALDI-MS after in-gel tryptic digestions.
  • The exogenous addition of other aromatic compounds also caused an increase in its activity, which in turn triggered NAD(P)H production via the action of dehydrogenases in the tricarboxylic acid cycle, heme biosynthesis via the action of aminolevulinic acid synthase on succinyl-CoA, and energy production via activation of the mitochondrial electron transfer system.

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  • (PMID = 16217726.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Benzaldehydes; 0 / Glyoxylates; 0 / Proteins; 9005-53-2 / Lignin; CHI530446X / vanillin; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.1.90 / aryl-alcohol dehydrogenase; EC 1.11.1.- / Peroxidases; EC 1.2.1.3 / Aldehyde Dehydrogenase; EC 4.1.3.1 / Isocitrate Lyase; JQ39C92HH6 / glyoxylic acid
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48. Wojtyczka RD, Kepa M, Brela R, Pacha J, Wydmuch Z, Idzik D: [Legal aspects of the supervision of nosocomial infection]. Wiad Lek; 2007;60(5-6):298-300
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  • [Transliterated title] Aspekty prawne nadzoru nad zakazeniami szpitalnymi.

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  • (PMID = 17966899.001).
  • [ISSN] 0043-5147
  • [Journal-full-title] Wiadomości lekarskie (Warsaw, Poland : 1960)
  • [ISO-abbreviation] Wiad. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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49. Newsome JJ, Colucci MA, Hassani M, Beall HD, Moody CJ: Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1. Org Biomol Chem; 2007 Nov 21;5(22):3665-73
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  • [Title] Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
  • The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined.
  • [MeSH-major] Benzimidazoles / metabolism. Benzothiazoles / metabolism. NAD(P)H Dehydrogenase (Quinone) / metabolism. Quinones / metabolism

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  • (PMID = 17971996.001).
  • [ISSN] 1477-0520
  • [Journal-full-title] Organic & biomolecular chemistry
  • [ISO-abbreviation] Org. Biomol. Chem.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / RR 17670
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzimidazoles; 0 / Benzothiazoles; 0 / Quinones; 0 / Recombinant Proteins; E24GX49LD8 / benzimidazole; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human; G5BW2593EP / benzothiazole
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50. Tsukatani T, Matsumoto K: Sequential fluorometric quantification of malic acid enantiomers by a single line flow-injection system using immobilized-enzyme reactors. Talanta; 2005 Jan 30;65(2):396-401
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  • Sample and coenzyme (NAD(+) or NADP(+)) were injected into the flow line by an open sandwich method. d-Malate was selectively oxidized by d-MDH when NAD(+) was injected with a sample.
  • When NADP(+) was injected with a sample, l-malate was oxidized only by l-MDH.
  • Linear relationships between the responses and concentrations of d-malate and l-malate were observed in the ranges of 1 x 10(-6)-1 x 10(-4)M and 1 x 10(-6)-2 x 10(-4)M, respectively.

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  • (PMID = 18969812.001).
  • [ISSN] 1873-3573
  • [Journal-full-title] Talanta
  • [ISO-abbreviation] Talanta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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51. Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA: Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. Clin Cancer Res; 2005 Apr 15;11(8):3055-64
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  • [Title] Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
  • beta-Lapachone, an o-naphthoquinone, induces a novel caspase- and p53-independent apoptotic pathway dependent on NAD(P)H:quinone oxidoreductase 1 (NQO1).
  • Interestingly, coadministration of N-acetyl-l-cysteine, prevented derivative-induced cytotoxicity but did not affect beta-lapachone lethality.
  • [MeSH-major] NAD(P)H Dehydrogenase (Quinone) / metabolism. Naphthoquinones / pharmacology. Prodrugs / pharmacology

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  • (PMID = 15837761.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA142543; United States / NCI NIH HHS / CA / R01 CA102792; United States / NCI NIH HHS / CA / 5T32 CA59366; United States / NCI NIH HHS / CA / R01 CA-92250
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Naphthoquinones; 0 / Prodrugs; 4707-32-8 / beta-lapachone; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human
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52. Wasco MJ, Pu RT, Yu L, Su L, Ma L: Expression of gamma-H2AX in melanocytic lesions. Hum Pathol; 2008 Nov;39(11):1614-20
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  • Previous studies have demonstrated the expression of gamma-H2AX in melanoma and dysplastic nevus, but its diagnostic and prognostic utility in a full range of melanocytic lesions has not been fully studied.
  • We found that gamma-H2AX was observed at higher levels (percentage and intensity of staining) in melanoma in situ (12/13), primary cutaneous melanoma (32/33; with the exception of desmoplastic melanoma), and metastatic melanoma (58/62), which was statistically different from that in benign nevus (7/9), dysplastic nevus (6/10), and Spitz nevus (5/9) considered together (P < .0001).
  • The overexpression of gamma-H2AX in melanoma as opposed to nevus indicates its possible role in melanomagenesis.
  • Based on the overlap in subsets of nevi and melanomas, the potential clinical utility of this antibody remains uncertain until further studies have been carried out in a larger cohort of melanocytic lesions, including borderline cases.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Histones / biosynthesis. Melanoma / metabolism. Nevus / metabolism
  • [MeSH-minor] Dysplastic Nevus Syndrome / metabolism. Female. Gene Expression. Humans. Male. Nevus, Epithelioid and Spindle Cell / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18656236.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / H2AFX protein, human; 0 / Histones
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53. Liu YJ, Norberg FE, Szilágyi A, De Paepe R, Akerlund HE, Rasmusson AG: The mitochondrial external NADPH dehydrogenase modulates the leaf NADPH/NADP+ ratio in transgenic Nicotiana sylvestris. Plant Cell Physiol; 2008 Feb;49(2):251-63
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  • Plant mitochondria contain alternative external NAD(P)H dehydrogenases, which oxidize cytosolic NADH or NADPH and reduce ubiquinone without inherent linkage to proton pumping and ATP production.
  • However, the AOX induction was substantially weaker than in the complex I-deficient CMSII mutant, previously shown to contain elevated amounts of NAD(P)H dehydrogenases and AOX.
  • The lines overexpressing St-ndb1 had consistently lowered leaf NADPH/NADP+ ratios in the light and variably decreased levels in darkness, but unchanged NADH/NAD+ ratios.
  • CMSII instead had similar NADPH/NADP+ and lower NADH/NAD+ ratios than the wild type.
  • These results demonstrate that St-NDB1 is able to modulate the cellular balance of NADPH and NADP+ at least in the day and that reduction of NADP(H) and NAD(H) is independently controlled.

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  • (PMID = 18182402.001).
  • [ISSN] 1471-9053
  • [Journal-full-title] Plant & cell physiology
  • [ISO-abbreviation] Plant Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Plant Proteins; 0 / Reactive Oxygen Species; 53-59-8 / NADP; EC 1.6.99.1 / NADPH Dehydrogenase
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5
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4. Yang M, Kahn AM: Insulin-inhibited and stimulated cultured vascular smooth muscle cell migration are related to divergent effects on protein phosphatase-2A and autonomous calcium/calmodulin-dependent protein kinase II. Atherosclerosis; 2008 Jan;196(1):227-33
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  • In the presence of angiotensin II (Ang II), insulin stimulates NAD(P)H oxidase activity leading to increased VSMC migration.
  • We wished to see whether insulin-stimulated cGMP stimulates protein phosphatase-2A (PP-2A) thereby inhibiting autonomous CaM kinase II and migration, and whether insulin, in the presence of Ang II, inhibits PP-2A and stimulates autonomous CaM kinase II in a NAD(P)H oxidase-dependent manner.
  • It is concluded that insulin in the presence of NO stimulates cGMP which stimulates PP-2A activity causing inhibition of autonomous CaM kinase II activity and thus VSMC migration, and that insulin in the presence of Ang II inhibits PP-2A and stimulates autonomous CaM kinase II activities by a NAD(P)H oxidase-dependent mechanism which are associated with insulin-stimulated NAD(P)H oxidase-dependent migration.

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  • (PMID = 17553505.001).
  • [ISSN] 1879-1484
  • [Journal-full-title] Atherosclerosis
  • [ISO-abbreviation] Atherosclerosis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Insulin; 11128-99-7 / Angiotensin II; 31C4KY9ESH / Nitric Oxide; 85-32-5 / Guanosine Monophosphate; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinase Type 2; EC 3.1.3.16 / Protein Phosphatase 2
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55. Panieri E, Toietta G, Mele M, Labate V, Ranieri SC, Fusco S, Tesori V, Antonini A, Maulucci G, De Spirito M, Galeotti T, Pani G: Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage. Aging (Albany NY); 2010 Aug;2(8):487-503
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  • Additionally, stimulation of the AMP-activated Protein Kinase concomitantly inhibited mTOR signaling and cell death, while neither event was affected by overexpression of the NAD+ dependent deacetylase Sirt-1, another cellular sensor of nutrient scarcity.

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  • (PMID = 20739737.001).
  • [ISSN] 1945-4589
  • [Journal-full-title] Aging
  • [ISO-abbreviation] Aging (Albany NY)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites; 0 / Culture Media, Serum-Free; 0 / Intracellular Signaling Peptides and Proteins; 0 / Ribosomal Protein S6; 9G2MP84A8W / Deoxyglucose; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / AMP-Activated Protein Kinases; EC 2.7.11.1 / Ribosomal Protein S6 Kinases; EC 3.5.1.- / Sirtuin 1
  • [Other-IDs] NLM/ PMC2954040
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56. Liu B, Lin Y, Darwanto A, Song X, Xu G, Zhang K: Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. J Biol Chem; 2009 Nov 20;284(47):32288-95
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  • Moreover, in vitro assays demonstrated that histone acetyltransferase p300 can catalyze H3 Lys(23) propionylation, whereas histone deacetylase Sir2 can remove this modification in the presence of NAD(+).

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  • (PMID = 19801601.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histones; EC 6.2.1.- / Coenzyme A Ligases; EC 6.2.1.17 / propionate - CoA ligase; K3Z4F929H6 / Lysine
  • [Other-IDs] NLM/ PMC2781642
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57. Niethammer P, Kueh HY, Mitchison TJ: Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Curr Biol; 2008 Apr 22;18(8):586-91
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  • Restriction of oxygen supply to the edge of a drop mimicked distance to the surface of a single cell, or distance from a blood vessel in tissue.
  • We imaged a step-like increase of Nicotinamide adenine dinucleotide (NAD) reduction approximately 600 microm distant from the oxygen source.
  • Addition of Adenosine triphosphate (ATP)-consuming beads mimicked local energy sinks in the cell.
  • We imaged Deltapsi gradients with a decay length of approximately 50-300 microm around these beads, in the first visualization of an energy demand signaling gradient.

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  • (PMID = 18406136.001).
  • [ISSN] 0960-9822
  • [Journal-full-title] Current biology : CB
  • [ISO-abbreviation] Curr. Biol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM039565-21; United States / NIGMS NIH HHS / GM / R01 GM039565; United States / NIGMS NIH HHS / GM / R01 GM039565-21
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0U46U6E8UK / NAD; S88TT14065 / Oxygen
  • [Other-IDs] NLM/ NIHMS208661; NLM/ PMC2902971
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58. Maestre E, Katakis I, Narváez A, Domínguez E: A multianalyte flow electrochemical cell: application to the simultaneous determination of carbohydrates based on bioelectrocatalytic detection. Biosens Bioelectron; 2005 Nov 15;21(5):774-81
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  • All the enzymatic sensors are mediated with different osmium compounds appropriate for each enzyme's mechanism (NAD or PQQ dehydrogenases) in some cases combining multienzyme sensors.
  • Cross referenced calibration curves were used for signal treatment and interpretation and it was possible to analyse real juice and milk samples with results agreeing with the standard enzymatic methods for the same analyses with a sampling frequency of more than 100 h(-1).

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  • (PMID = 16242617.001).
  • [ISSN] 0956-5663
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbohydrates; 0 / Complex Mixtures; 0 / Enzymes, Immobilized; EC 1.1.1.47 / Glucose 1-Dehydrogenase
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59. Shabalin IG, Filippova EV, Polyakov KM, Sadykhov EG, Safonova TN, Tikhonova TV, Tishkov VI, Popov VO: Structures of the apo and holo forms of formate dehydrogenase from the bacterium Moraxella sp. C-1: towards understanding the mechanism of the closure of the interdomain cleft. Acta Crystallogr D Biol Crystallogr; 2009 Dec;65(Pt 12):1315-25
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  • NAD(+)-dependent formate dehydrogenase (FDH) catalyzes the oxidation of formate ion to carbon dioxide coupled with the reduction of NAD(+) to NADH.
  • Apo MorFDH has a closed conformation of the interdomain cleft, which is unique for an apo form of an NAD(+)-dependent dehydrogenase.

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  • (PMID = 19966418.001).
  • [ISSN] 1399-0047
  • [Journal-full-title] Acta crystallographica. Section D, Biological crystallography
  • [ISO-abbreviation] Acta Crystallogr. D Biol. Crystallogr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apoenzymes; 0 / Holoenzymes; EC 1.2.1.2 / Formate Dehydrogenases
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60. Celebi JT, Ward KM, Wanner M, Polsky D, Kopf AW: Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome. Clin Exp Dermatol; 2005 Jan;30(1):68-70
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  • [Title] Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome.
  • Atypical mole syndrome is a sporadic or an inherited condition with an increased risk of melanoma.
  • In this study, we evaluated genes associated with familial and sporadic melanoma for mutations in 28 probands with the atypical mole syndrome.
  • These data suggest that genes evaluated in this study are unlikely to be candidate genes for atypical mole syndrome and support the notion that unknown susceptibility gene/s for this disease exist.
  • [MeSH-major] Dysplastic Nevus Syndrome / genetics. Germ-Line Mutation / genetics. Melanoma / genetics. Middle Aged. Skin Neoplasms / genetics

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  • (PMID = 15663508.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 2.7.11.22 / Cyclin-Dependent Kinases; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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66. Spallarossa P, Altieri P, Pronzato P, Aloi C, Ghigliotti G, Barsotti A, Brunelli C: Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane. J Pharmacol Exp Ther; 2010 Jan;332(1):87-96
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  • ErbB2 expression levels, AKT activation, and the effects of the inhibition of nicotinamide adenine dinucleotide phosphate oxidase [NAD(P)H oxidase] and phosphoinositide-3-OH kinase (PI3K) were also assessed.
  • Data demonstrate that 1) the toxic effects of epirubicin mainly occur through NAD(P)H oxidase activation;.
  • 2) the erbB2 overexpression induced by epirubicin is a redox-sensitive mechanism largely dependent on NAD(P)H oxidase;.
  • Data underline the importance of NAD(P)H oxidase in epirubicin-induced cardiotoxicity and shed new light on the protective mechanisms of dexrazoxane.

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  • (PMID = 19841470.001).
  • [ISSN] 1521-0103
  • [Journal-full-title] The Journal of pharmacology and experimental therapeutics
  • [ISO-abbreviation] J. Pharmacol. Exp. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Cardiotonic Agents; 0 / Erbb2 protein, rat; 0 / Glycoproteins; 3Z8479ZZ5X / Epirubicin; 5AR83PR647 / Razoxane; EC 2.7.10.1 / Receptor, ErbB-2
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67. Xu S, He Y, Vokurkova M, Touyz RM: Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of thioredoxin. Hypertension; 2009 Aug;54(2):427-33
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  • Using a coculture system we tested whether ECs modulate VSMC redox status by regulating activity of NAD(P)H oxidase and antioxidants.
  • NAD(P)H oxidase subunit expression and oxidase activity were determined by Western blotting and chemiluminescence, respectively.
  • In cocultured conditions, VSMC ROS production was reduced by approximately 50% without changes in NAD(P)H oxidase expression/activity versus monoculture (P<0.05).
  • The modulatory actions of ECs are independent of NOS/NO, Cox2, and HETE and do not involve NAD(P)H oxidase.


68. Hisahara S, Chiba S, Matsumoto H, Horio Y: Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha). J Pharmacol Sci; 2005 Jul;98(3):200-4
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  • [Title] Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha).
  • Sir2 (silent information regulator 2) is an NAD-dependent deacetylase that is broadly conserved from bacteria to humans.
  • It catalyzes a unique deacetylation reaction using NAD, and specific inhibitors and activators of its activity have been discovered.
  • [MeSH-minor] Animals. Basic Helix-Loop-Helix Transcription Factors. DNA-Binding Proteins / physiology. Forkhead Transcription Factors. Hepatocyte Nuclear Factor 3-gamma. Humans. NAD / metabolism. Nuclear Proteins / physiology. Signal Transduction. Sirtuin 1. Transcription Factors / physiology. Transcription, Genetic

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  • (PMID = 16006743.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / DNA-Binding Proteins; 0 / FOXA3 protein, human; 0 / FOXO1 protein, human; 0 / Forkhead Transcription Factors; 0 / Nuclear Proteins; 0 / Transcription Factors; 0U46U6E8UK / NAD; 135845-91-9 / Hepatocyte Nuclear Factor 3-gamma; EC 3.5.1.- / SIRT1 protein, human; EC 3.5.1.- / Sirtuin 1; EC 3.5.1.- / Sirtuins; EC 3.5.1.98 / Histone Deacetylases
  • [Number-of-references] 41
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69. Skwara P, Mach T, Tomaszewska R, Sobczyk-Krupiarz I, Cieśla A: [Studies on relationship between immunodeficiency in HIV-infected people and condition of upper gastrointestinal tract mucosa, prevalence of mycosis and Helicobacter pylori infection]. Przegl Lek; 2005;62(12):1401-4
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  • [Transliterated title] Badania nad zaleznościa upośledzenia odporności u osób zakazonych HIV a stanem błony sluzowej górnego odcinka przewodu pokarmowego, wystepowaniem grzybicy i infekcji Helicobacter pylori.


70. Smach MA, Charfeddine B, Ben Othman L, Lammouchi T, Dridi H, Nafati S, Ltaief A, Bennamou S, Limem K: Evaluation of cerebrospinal fluid tau/beta-amyloid(42) ratio as diagnostic markers for Alzheimer disease. Eur Neurol; 2009;62(6):349-55
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  • AIM: The objective of this study was to investigate the usefulness of CSF Abeta1-42 and T-tau analyses in the diagnosis of AD with Tunisians.
  • METHODS: We focused on three groups originating from Central Tunisian that matched in age (range 48-85): healthy controls (n = 53), AD patients (n = 93) and non-Alzheimer (nAD) dementia (n = 35) patients.
  • RESULTS: The ratio of T-tau/Abeta1-42 at baseline yielded a sensitivity of 85.3% for detection of AD and the specificity was 84.8% to differentiate controls and nAD dementia.
  • [MeSH-major] Alzheimer Disease / diagnosis. Amyloid beta-Peptides / cerebrospinal fluid. Peptide Fragments / cerebrospinal fluid. tau Proteins / cerebrospinal fluid
  • [MeSH-minor] Aged. Aged, 80 and over. Analysis of Variance. Biomarkers / cerebrospinal fluid. Chi-Square Distribution. Cognition Disorders / cerebrospinal fluid. Cognition Disorders / diagnosis. Diagnosis, Differential. Diagnostic and Statistical Manual of Mental Disorders. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neuropsychological Tests. Phosphorylation. Statistics, Nonparametric

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  • (PMID = 19786779.001).
  • [ISSN] 1421-9913
  • [Journal-full-title] European neurology
  • [ISO-abbreviation] Eur. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Amyloid beta-Peptides; 0 / Biomarkers; 0 / Peptide Fragments; 0 / amyloid beta-protein (1-42); 0 / tau Proteins
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71. Khan MI, Ito K, Kim H, Ashida H, Ishikawa T, Shibata H, Sawa Y: Molecular properties and enhancement of thermostability by random mutagenesis of glutamate dehydrogenase from Bacillus subtilis. Biosci Biotechnol Biochem; 2005 Oct;69(10):1861-70
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  • The recombinant Bs-GluDH was purified to homogeneity and has been determined to have a hexameric structure (M(r) 270 kDa) with strict specificity for 2-oxoglutarate and L-glutamate, requiring NADH and NAD+ as cofactors respectively.
  • [MeSH-minor] Cloning, Molecular. Dimerization. Enzyme Stability. Glutamic Acid / metabolism. Hot Temperature. Ketoglutaric Acids / metabolism. Kinetics. Molecular Weight. Mutation, Missense. NAD. Substrate Specificity / genetics

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  • (PMID = 16244435.001).
  • [ISSN] 0916-8451
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ketoglutaric Acids; 0U46U6E8UK / NAD; 328-50-7 / alpha-ketoglutaric acid; 3KX376GY7L / Glutamic Acid; EC 1.4.1.2 / Glutamate Dehydrogenase
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72. Scope A, Busam KJ, Malvehy J, Puig S, McClain SA, Braun RP, Marghoob AA: Ex vivo dermoscopy of melanocytic tumors: time for dermatopathologists to learn dermoscopy. Arch Dermatol; 2007 Dec;143(12):1548-52
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  • BACKGROUND: We have identified cases of skin cancer with discordances between clinical, dermoscopic, and histopathologic findings that were likely due to sampling errors in the pathology laboratory.
  • OBSERVATIONS: The orientation of the lesion, overall dermoscopic pattern, and dermoscopic pigmented structures (network, globules, and peripheral streaks) were readily correlated between the in vivo and ex vivo images for 2 melanomas and 4 dysplastic nevi.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy. Dysplastic Nevus Syndrome / pathology. Melanocytes / pathology. Melanoma / pathology. Skin Neoplasms / pathology


73. Holbourn KP, Shone CC, Acharya KR: A family of killer toxins. Exploring the mechanism of ADP-ribosylating toxins. FEBS J; 2006 Oct;273(20):4579-93
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  • The ADP-ribosylating toxins (ADPRTs) are a family of toxins that catalyse the hydrolysis of NAD and the transfer of the ADP-ribose moiety onto a target.
  • This family includes many notorious killers, responsible for thousands of deaths annually including: cholera, enterotoxic Escherichia coli, whooping cough, diphtheria and a plethora of Clostridial binary toxins.
  • They all share a common fold and several motifs around the active site that collectively facilitate the binding and transfer of the ADP-ribose moiety of NAD to their protein targets.
  • [MeSH-minor] Amino Acid Motifs. Amino Acid Sequence. Binding Sites. Conserved Sequence. Models, Molecular. Molecular Sequence Data. NAD / metabolism. Sequence Alignment

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  • (PMID = 16956368.001).
  • [ISSN] 1742-464X
  • [Journal-full-title] The FEBS journal
  • [ISO-abbreviation] FEBS J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Toxins, Biological; 0U46U6E8UK / NAD; EC 2.4.2.- / ADP Ribose Transferases
  • [Number-of-references] 88
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74. Ma B, Pan SJ, Zupancic ML, Cormack BP: Assimilation of NAD(+) precursors in Candida glabrata. Mol Microbiol; 2007 Oct;66(1):14-25
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  • [Title] Assimilation of NAD(+) precursors in Candida glabrata.
  • The yeast pathogen Candida glabrata is a nicotinamide adenine dinucleotide (NAD(+)) auxotroph and its growth depends on the environmental supply of vitamin precursors of NAD(+). C. glabrata salvage pathways defined in this article allow NAD(+) to be synthesized from three compounds - nicotinic acid (NA), nicotinamide (NAM) and nicotinamide riboside (NR).
  • The second is a novel pathway in which NR is degraded by the nucleosidases Pnp1 and Urh1, with a minor role for Meu1, and ultimately converted to NAD(+) via the nicotinamidase Pnc1 and the Preiss-Handler pathway.
  • Using C. glabrata mutants whose growth depends exclusively on the external NA or NR supply, we also show that C. glabrata utilizes NR and to a lesser extent NA as NAD(+) sources during disseminated infection.
  • [MeSH-major] Candida glabrata / metabolism. Metabolic Networks and Pathways. NAD / biosynthesis

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  • (PMID = 17725566.001).
  • [ISSN] 0950-382X
  • [Journal-full-title] Molecular microbiology
  • [ISO-abbreviation] Mol. Microbiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / 2P01DK49720; United States / NIAID NIH HHS / AI / 5R01AI046223-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0U46U6E8UK / NAD; 1341-23-7 / nicotinamide-beta-riboside; 25X51I8RD4 / Niacinamide; 2679MF687A / Niacin; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / nicotinamide riboside kinase; EC 3.2.2.- / N-Glycosyl Hydrolases; EC 3.5.1.19 / Nicotinamidase
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75. Dasgupta BR, Antharavally BS, Tepp W, Evenson ML: Botulinum neurotoxin types A, B, and E: fragmentations by autoproteolysis and other mechanisms including by O-phenanthroline-dithiothreitol, and association of the dinucleotides NAD(+)/NADH with the heavy chain of the three neurotoxins. Protein J; 2005 Aug;24(6):337-68
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  • [Title] Botulinum neurotoxin types A, B, and E: fragmentations by autoproteolysis and other mechanisms including by O-phenanthroline-dithiothreitol, and association of the dinucleotides NAD(+)/NADH with the heavy chain of the three neurotoxins.
  • The first evidence of autoproteolytic activity of the approximately 50-kDa light chain of the clostridial neurotoxins (NT) is traceable to the observations that the light chains of botulinum NT serotypes A and E, separated from their approximately 100-kDa heavy chain conjugate, were found cleaved at the amino side of Tyr250 and Arg244, respectively [DasGupta and Foley (1989).
  • None of the identified cleaved bonds (-P1-P1' -) in one serotype (except Asp-Pro) was found common in other serotypes or cleaved within itself at a second site.
  • After separation from the heavy chain self-cleavages of the light chains of type A, B and E at Tyr249-Tyr250, Gln258-Ser259 and Ile243-Arg244, respectively indicate an intriguing feature (in the aligned sequences these bonds of type A and B are 2 and type A and E are 4 peptide bonds apart) that may have some role in the NT's structure-function relationship yet to be understood.
  • We point out that autoproteolysis of a single peptide bond (Phe418-Thr419 or Phe422-Glu423) in NT type A reported by Ahmed et al. (2001) can potentially generate proteolytically active light chain freed of the heavy chain; this is an efficient pathway, that by-passes nicking by a trypsin-like protease(s) inside the intrachain disulfide bridge and its reductive cleavage.
  • The metal chelator O-phenanthroline (above critical miceller concentration) in the presence of dithiothreitol cleaved type E NT at limited sites generating discrete 114-, 87-, 49-, 42-, and 31-kDa fragments but degraded NTs type A and B extensively.
  • The dinucleotide NAD(+)/NADH associated with the NTs type A, B and E (2-3 NADH per protein molecule) via their H-chains, and a portion of the H-chain (toward the C-terminus) appears to exhibit limited amino acid sequence homology with lactate dehydrogenase-a representative NAD(+)/NADH binding protein.
  • [MeSH-minor] Amino Acid Sequence. Botulinum Toxins, Type A / metabolism. Dithiothreitol. L-Lactate Dehydrogenase / chemistry. Molecular Weight. NAD / metabolism. Peptide Hydrolases / metabolism. Phenanthrolines. Sequence Homology, Amino Acid

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  • (PMID = 16323041.001).
  • [ISSN] 1572-3887
  • [Journal-full-title] The protein journal
  • [ISO-abbreviation] Protein J.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS17742; United States / NINDS NIH HHS / NS / NS24545
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Peptide Fragments; 0 / Phenanthrolines; 0U46U6E8UK / NAD; 0Y70779M1F / rimabotulinumtoxinB; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 3.4.- / Peptide Hydrolases; EC 3.4.24.69 / Botulinum Toxins; EC 3.4.24.69 / Botulinum Toxins, Type A; T579M564JY / botulinum toxin type E; T8ID5YZU6Y / Dithiothreitol; W4X6ZO7939 / 1,10-phenanthroline
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76. Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Lee WH, Adamski J, Oppermann U: Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. Biochem J; 2007 Mar 15;402(3):419-27
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  • In vitro, DHRS10 converts NAD+ into NADH in the presence of oestradiol, testosterone and 5-androstene-3beta,17beta-diol.
  • Furthermore, the product of oestradiol oxidation, oestrone, was identified in intact cells transfected with a construct plasmid encoding the DHRS10 protein.
  • It also reveals a broad and deep active site cleft into which NAD+ and oestradiol can be docked in a catalytically competent orientation.

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  • [ErratumIn] Biochem J. 2007 May 1;403(3):615. Kavanagh, Kathryn [Kavanagh, Kathryn L]; Hwa, Lee Wen [corrected to Lee, Wen Hwa]
  • (PMID = 17067289.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] ENG
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ligands; 0U46U6E8UK / NAD; EC 1.1.- / 17-Hydroxysteroid Dehydrogenases; EC 1.1.- / HSD17B14 protein, human
  • [Other-IDs] NLM/ PMC1863559
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77. Rey P, Lopez-Real A, Sanchez-Iglesias S, Muñoz A, Soto-Otero R, Labandeira-Garcia JL: Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons. Neurobiol Aging; 2007 Apr;28(4):555-67
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  • Angiotensin II activates (via type 1 receptors) NAD(P)H-dependent oxidases, which are a major source of superoxide, and is relevant in the pathogenesis of several cardiovascular diseases and certain degenerative changes associated with ageing.
  • Dopaminergic degeneration was also reduced by the NAD(P)H inhibitor apocynin.

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  • (PMID = 16621167.001).
  • [ISSN] 1558-1497
  • [Journal-full-title] Neurobiology of aging
  • [ISO-abbreviation] Neurobiol. Aging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic Agents; 0 / Angiotensin II Type 1 Receptor Blockers; 0 / Naphthyridines; 0 / Thiobarbituric Acid Reactive Substances; 0 / ZD 7155; 8HW4YBZ748 / Oxidopamine; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; VTD58H1Z2X / Dopamine
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78. Dhawan AP, D'Alessandro B, Patwardhan S, Mullani N: Multispectral optical imaging of skin-lesions for detection of malignant melanomas. Conf Proc IEEE Eng Med Biol Soc; 2009;2009:5352-5
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  • [Title] Multispectral optical imaging of skin-lesions for detection of malignant melanomas.
  • Optical imaging of skin-lesions for early detection and management of the most fatal skin-cancer malignant melanoma is of significant interest in mass screening of skin-lesions with high-risk population.
  • Surface illumination based optical imaging methods such as epiluminescence light microscopy (ELM) through "Dermascopy" has shown a significant potential in improving early diagnosis of malignant melanomas.
  • We have developed a novel optical imaging system, the Nevoscope, that uses multispectral transillumination as to provide images of skin-lesions showing sub-surface pigmentation as well as vascular architecture based blood volume information.
  • This paper presents multispectral Nevoscope transillumination method to compare and analyze ratiometric measurements to epiluminescence imaging for its ability to discriminate malignant melanomas from dysplastic nevi and other normal skin-lesions.
  • [MeSH-major] Melanoma / diagnosis. Skin Neoplasms / diagnosis. Transillumination / instrumentation. Transillumination / methods

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  • (PMID = 19964673.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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79. Sorrentino SA, Bahlmann FH, Besler C, Müller M, Schulz S, Kirchhoff N, Doerries C, Horváth T, Limbourg A, Limbourg F, Fliser D, Haller H, Drexler H, Landmesser U: Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation; 2007 Jul 10;116(2):163-73
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  • Small-interfering RNA silencing of NAD(P)H oxidase subunit p47(phox) reduced superoxide production and restored NO bioavailability and in vivo reendothelialization capacity of EPCs from diabetic patients.
  • Importantly, rosiglitazone therapy normalized NAD(P)H oxidase activity, restored NO bioavailability, and improved in vivo reendothelialization capacity of EPCs from diabetic patients (reendothelialized area: placebo versus rosiglitazone, 8+/-1% versus 38+/-5%; P<0.001).
  • CONCLUSIONS: In vivo reendothelialization capacity of EPCs derived from individuals with diabetes mellitus is severely impaired at least partially as a result of increased NAD(P)H oxidase-dependent superoxide production and subsequently reduced NO bioavailability.
  • Rosiglitazone therapy reduces NAD(P)H oxidase activity and improves reendothelialization capacity of EPCs from diabetic individuals, representing a potential novel mechanism whereby peroxisome proliferator-activated receptor-gamma agonism promotes vascular repair.


80. Izzicupo P, Di Valerio V, D' Amico MA, Di Mauro M, Pennelli A, Falone S, Alberti G, Amicarelli F, Miscia S, Gallina S, Di Baldassarre A: NAD(P)H oxidase and pro-inflammatory response during maximal exercise: role of C242T polymorphism of the P22PHOX subunit. Int J Immunopathol Pharmacol; 2010 Jan-Mar;23(1):203-11
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  • [Title] NAD(P)H oxidase and pro-inflammatory response during maximal exercise: role of C242T polymorphism of the P22PHOX subunit.
  • Intense exercise induces a pro-inflammatory status through a mechanism involving the NAD(P)H oxidase system.
  • We focused our attention on p22phox, a subunit of the NAD(P)H oxidase, and on its allelic polymorphism C242T, which is known to affect the functional activity of the enzyme.
  • In addition, the presence of T allele was associated with a higher cardiopulmonary efficiency as evidenced by a significantly lower Heart Rate (HR) at the peak of exercise and, when a dominant model was assumed, by a higher maximal oxygen uptake (VO2 max).
  • These results contribute to support the hypothesis of a systemic effect for the C242T polymorphism and of its possible functional rebound in healthy subjects.

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  • (PMID = 20378006.001).
  • [ISSN] 0394-6320
  • [Journal-full-title] International journal of immunopathology and pharmacology
  • [ISO-abbreviation] Int J Immunopathol Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Reactive Oxygen Species; EC 1.11.1.7 / Peroxidase; EC 1.6.3.1 / CYBA protein, human; EC 1.6.3.1 / NADPH Oxidase; WI4X0X7BPJ / Hydrocortisone
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81. Chen R, Chen JY, Zhou LW: Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging. Ultrastruct Pathol; 2008 Sep-Oct;32(5):193-8
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  • [Title] Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging.
  • Although the spatial and temporal distributions of cellular NAD(P)H concentrations have been theoretically predicted as typical patterns of the metabolism in living cells, so far such a pattern was observed only in neutrophils.
  • In this work, the dynamic NAD(P)H distributions in rat basophilic leukemia (RBL-2H3) and human hepatocellular carcinoma (Hep G2) cells were studied by imaging the autofluorescence of cellular NAD(P)H with a sensitive CCD detector in a confocal microscope.
  • The typical pattern of the cytoplasmic NAD(P)H wave traveling along the long axis of the elongated cell with a velocity of 2.2+/-0.6 mircom/s was detected in RBL-2H3 cells.
  • While in the case of Hep G2 cells, only the oscillation of the mitochondrial NAD(P)H was observed because the NAD(P)H mainly localized in mitochondria of Hep G2 cells.
  • These results confirm the metabolic pattern of NAD(P)H in living cells and suggest that the expression of the metabolic pattern probably differs in different cell lines.

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  • (PMID = 18958792.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 53-59-8 / NADP
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82. Horenstein AL, Sizzano F, Lusso R, Besso FG, Ferrero E, Deaglio S, Corno F, Malavasi F: CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus. Mol Med; 2009 Mar-Apr;15(3-4):76-84
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  • Nicotinamide adenine dinucleotide (NAD(+)), a precursor of molecules involved in cell regulatory processes, is released in extra-cellular compartments after stress or inflammation.This study investigates the expression in the human cornea of CD38 and CD157, two NAD(+)-consuming ectoenzymes and surface receptors.
  • The presence of enzymatically active NAD(+)-consumers in intact corneal cells was analyzed by high performance liquid chromatography (HPLC)-based assays.
  • The results of the work indicates that the human cornea is equipped with molecular tools capable of consuming extracellular NAD(+), and that CD157 is a potential marker of corneal limbal cells in the stem cell niche.
  • [MeSH-minor] Biomarkers / metabolism. Cornea / anatomy & histology. Cornea / metabolism. GPI-Linked Proteins. Humans. NAD / metabolism

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  • (PMID = 19052657.001).
  • [ISSN] 1528-3658
  • [Journal-full-title] Molecular medicine (Cambridge, Mass.)
  • [ISO-abbreviation] Mol. Med.
  • [Language] eng
  • [Grant] Italy / Telethon / / GTF06004
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers; 0 / GPI-Linked Proteins; 0U46U6E8UK / NAD; EC 3.2.2.5 / ADP-ribosyl Cyclase; EC 3.2.2.5 / ADP-ribosyl cyclase 2; EC 3.2.2.5 / Antigens, CD38
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83. Slominska EM, Yuen A, Osman L, Gebicki J, Yacoub MH, Smolenski RT: Cytoprotective effects of nicotinamide derivatives in endothelial cells. Nucleosides Nucleotides Nucleic Acids; 2008 Jun;27(6):863-6
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  • [Title] Cytoprotective effects of nicotinamide derivatives in endothelial cells.
  • Following discovery of NAD(+)-dependent reactions that control gene expression, cytoprotection, and longevity, there has been a renewed therapeutic interest in precursors, such as nicotinamide and its derivatives.
  • We tested 20 analogues of nicotinamide for their ability to protect endothelial cells from peroxynitrite stress and their effect on poly (ADP-ribose) polymerase (PARP) activity.
  • Several nicotinamide derivatives protected endothelial cells from peroxynitrite-induced depletion of cellular NAD(+) and ATP concentrations, but only some of these compounds inhibited PARP.
  • We conclude that some nicotinamide derivatives provide protection of endothelial cells against peroxynitrite-induced injury independent of inhibition of PARP activity.
  • Preservation of the NAD(+) pool was a common effect of these compounds.
  • [MeSH-minor] Cell Line. Humans. NAD / metabolism. Poly(ADP-ribose) Polymerase Inhibitors. Time Factors

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  • (PMID = 18600553.001).
  • [ISSN] 1532-2335
  • [Journal-full-title] Nucleosides, nucleotides & nucleic acids
  • [ISO-abbreviation] Nucleosides Nucleotides Nucleic Acids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Poly(ADP-ribose) Polymerase Inhibitors; 0U46U6E8UK / NAD; 25X51I8RD4 / Niacinamide
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84. Bychkov PV, Shekhovtsova TN, Milaeva ER: Inhibition of horse liver alcohol dehydrogenase by methyltin compounds. Bioinorg Chem Appl; 2005;:191-9
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  • Data acquired on NAD-dependent ADH from horse liver and those regarding NAD-dependent LDH from sturgeon liver were compared.

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  • (PMID = 18365099.001).
  • [ISSN] 1565-3633
  • [Journal-full-title] Bioinorganic chemistry and applications
  • [ISO-abbreviation] Bioinorg Chem Appl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2267099
  • [Keywords] NOTNLM ; NAD / alcohol dehydrogenase / inhibition type / methyltin compounds
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85. Brimfield AA, Novak MJ, Hodgson E: Thiodiglycol, the hydrolysis product of sulfur mustard: analysis of in vitro biotransformation by mammalian alcohol dehydrogenases using nuclear magnetic resonance. Toxicol Appl Pharmacol; 2006 Jun 15;213(3):207-15
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  • The intermediate nature of this mixture was determined spectrophotometrically when it was shown to drive the production of NADH when added to ADH and NAD.

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  • (PMID = 16417912.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Sulfhydryl Compounds; 9BW5T43J04 / 2,2'-thiodiethanol; EC 1.1.1.1 / Alcohol Dehydrogenase; T8KEC9FH9P / Mustard Gas
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86. Lebe B, Pabuççuoglu U, Ozer E: Expression pattern of type IV collagen in sporadic dysplastic melanocytic nevi. Anal Quant Cytol Histol; 2008 Oct;30(5):291-6
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  • [Title] Expression pattern of type IV collagen in sporadic dysplastic melanocytic nevi.
  • OBJECTIVE: To investigate the expression and distribution pattern of type IV collagen in dysplastic nevi (DN) and to determine whether DN exhibits a morphologic difference from common melanocytic nevi (CMN) and cutaneous malignant melanomas (MM) and therefore can be classified as a separate entity.
  • STUDY DESIGN: We examined 33 DN specimens, 18 CMN specimens, and 10 MM specimens.
  • Twenty-one of 33 DN showed a continuous pattern of type IV collagen surrounding junctional nests in a concentric fashion while a discontinuous immunostaining pattern was observed in remaining cases.
  • The expression pattern of type IV collagen in DN was statistically different from CMN and MM.
  • CONCLUSION: Our results suggest sporadic DN is biologically different from CMN in terms of the capacity to synthesize type IV collagen, demonstrating that DN is not only morphologically but also biologically a different entity from CMN.

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  • (PMID = 18980161.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type IV
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87. Barranco WT, Kim DH, Stella SL Jr, Eckhert CD: Boric acid inhibits stored Ca2+ release in DU-145 prostate cancer cells. Cell Biol Toxicol; 2009 Aug;25(4):309-20
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  • In this paper, we report that boric acid (BA) inhibits NAD+ and NADP+ as well as mechanically induced release of stored Ca2+ in growing DU-145 prostate cancer cells.
  • NAD+-induced Ca2+ transients were partly inhibited at 250 microM BA and completely at 1,000 microM BA, whereas both NADP+ and mechanically induced transients were inhibited by 1,000 microM BA.
  • In vitro mass spectrometry analysis showed that BA formed adducts with the CD38 products and Ca2+ channel agonists cyclic adenosine diphosphate ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP).
  • The BA analog, methylboronic acid (MBA; 250 and 1,000 microM), did not inhibit cell proliferation or NAD+, NADP+, or mechanically stimulated Ca2+ store release.
  • [MeSH-minor] Antigens, CD38 / metabolism. Calcium Signaling / drug effects. Cell Line, Tumor. Cyclic ADP-Ribose / metabolism. Humans. Male. NAD / metabolism. NADP / metabolism

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  • (PMID = 18516691.001).
  • [ISSN] 1573-6822
  • [Journal-full-title] Cell biology and toxicology
  • [ISO-abbreviation] Cell Biol. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Boric Acids; 0U46U6E8UK / NAD; 119340-53-3 / Cyclic ADP-Ribose; 53-59-8 / NADP; EC 3.2.2.5 / Antigens, CD38; R57ZHV85D4 / boric acid; SY7Q814VUP / Calcium
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88. Casalino E, Calzaretti G, Landriscina M, Sblano C, Fabiano A, Landriscina C: The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase. Toxicology; 2007 Jul 31;237(1-3):24-34
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  • [Title] The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase.
  • The stimulation is associated with a higher level of alpha-class GST proteins, whose induction is blocked by actinomycin D co-administration.
  • For comparison, we have evaluated the status of another important antioxidant enzyme, NAD(P)H:quinone reductase, 24h after cadmium or manganese administration.
  • [MeSH-major] Cadmium Chloride / toxicity. Chlorides / toxicity. Glutathione Transferase / biosynthesis. Isoenzymes / biosynthesis. Liver. NAD(P)H Dehydrogenase (Quinone) / biosynthesis. NF-E2 Transcription Factor, p45 Subunit / physiology

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  • (PMID = 17573173.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Chlorides; 0 / Enzyme Inhibitors; 0 / Isoenzymes; 0 / Manganese Compounds; 0 / NF-E2 Transcription Factor, p45 Subunit; 99Z2744345 / Ditiocarb; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, rat; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase alpha; H6241UJ22B / Selenium; J6K4F9V3BA / Cadmium Chloride; QQE170PANO / manganese chloride
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89. Diani-Moore S, Ram P, Li X, Mondal P, Youn DY, Sauve AA, Rifkind AB: Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect. J Biol Chem; 2010 Dec 10;285(50):38801-10
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  • [Title] Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect.
  • TCDD suppressed hepatic glucose production, expression of key gluconeogenic genes, phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6Pase), and NAD(+) levels, and increased PARP activity and TiPARP expression.
  • TiPARP overexpression reproduced TCDD effects on glucose output and NAD(+) levels whereas TiPARP silencing diminished them.
  • The vitamin B3 constituent, nicotinamide (NAM), prevented TCDD suppression of glucose output, NAD(+), and gluconeogenic genes and stabilized PGC1α.
  • The corrective effects of NAM could be attributed to increased NAD(+) levels and suppression of AHR target gene induction.

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  • (PMID = 20876576.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA062948; United States / NCI NIH HHS / CA / T32-CA062948; United States / NIDDK NIH HHS / DK / R01-DK73466; United States / NIEHS NIH HHS / ES / R01 ES003606; United States / NIEHS NIH HHS / ES / R01-ES03606; United States / NIDDK NIH HHS / DK / R01 DK073466; United States / NCI NIH HHS / CB / N02-CB-666000
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Aryl Hydrocarbon; 0 / Transcription Factors; 0U46U6E8UK / NAD; 25X51I8RD4 / Niacinamide; 9005-79-2 / Glycogen; DO80M48B6O / Tetrachlorodibenzodioxin; EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.5.1.- / SIRT1 protein, human; EC 3.5.1.- / Sirtuin 1; IY9XDZ35W2 / Glucose
  • [Other-IDs] NLM/ PMC2998137
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90. Wojnowski W, Obrebowski A, Pruszewicz A, Demenko G, Wiskirska-Woźnica B, Swidziński P: [Further research on speech tests]. Otolaryngol Pol; 2007;61(6):979-82
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  • [Transliterated title] Dalsze badania nad testami mowy utrudnionej.
  • [MeSH-major] Audiometry, Speech. Hearing Disorders / diagnosis. Noise

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  • (PMID = 18546946.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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91. Chan KM, Rajab NF, Siegel D, Din LB, Ross D, Inayat-Hussain SH: Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway. Toxicol Sci; 2010 Aug;116(2):533-48
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  • However, the p53 elevation in GN-treated CASMCs was independent of NAD(P)H: quinone oxidoreductase 1 and Mdm-2 expression.
  • [MeSH-minor] Adenosine Triphosphate / analysis. Amino Acid Chloromethyl Ketones / pharmacology. Cells, Cultured. Cytochromes c / secretion. Dose-Response Relationship, Drug. Enzyme Activation. Humans. Hydrogen Peroxide / metabolism. Membrane Potential, Mitochondrial / drug effects. NAD(P)H Dehydrogenase (Quinone) / metabolism. Oxygen Consumption / drug effects. Superoxides / metabolism

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  • (PMID = 20498002.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acid Chloromethyl Ketones; 0 / Pyrones; 0 / Tumor Suppressor Protein p53; 0 / benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; 11062-77-4 / Superoxides; 34W9GO6B2Z / goniothalamin; 8L70Q75FXE / Adenosine Triphosphate; 9007-43-6 / Cytochromes c; BBX060AN9V / Hydrogen Peroxide; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human; EC 3.4.22.- / Caspase 2
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92. Xiao T, Shoeb M, Siddiqui MS, Zhang M, Ramana KV, Srivastava SK, Vasiliou V, Ansari NH: Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes. J Toxicol Environ Health A; 2009;72(9):577-84
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  • The purified recombinant human lens ALDH1A1 exhibited optimal catalytic activity at pH 8 and preferred NAD(+) as cofactor and specifically catalyzed the oxidation of toxic lipid aldehydes such as 4-hydroxynonenal (HNE; K(m) = 4.8 microM) and malonaldehyde (K(m) MDA = 3.5 microM).
  • Further, modification of recombinant human lens ALDH1A1 with nitric oxide donors such as S-nitroso-N-acetylpenicillamine (SNAP) and S-nitrosoglutathione (GSNO) significantly inhibited the enzyme activity.

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  • (PMID = 19296407.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / R29 EY011490; United States / NEI NIH HHS / EY / R01 EY013014; United States / NEI NIH HHS / EY / EY13014; United States / NEI NIH HHS / EY / R01 EY011490; United States / NEI NIH HHS / EY / EY11490; United States / NIDDK NIH HHS / DK / R37 DK036118
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Recombinant Proteins; EC 1.2.1.3 / ALDH1A1 protein, human; EC 1.2.1.3 / Aldehyde Dehydrogenase
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93. Rathbone CR, Booth FW, Lees SJ: Sirt1 increases skeletal muscle precursor cell proliferation. Eur J Cell Biol; 2009 Jan;88(1):35-44
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  • Over-expression of the NAD+-dependent histone deacetylase Sirt1 increased MPC proliferation and cell cycle progression as evidenced by increased 5-bromo-2'-deoxyuridine (BrdU) incorporation, an increase in cell number, proliferating cell nuclear antigen expression, and the phosphorylation of retinoblastoma protein.
  • Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation.

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  • (PMID = 18922599.001).
  • [ISSN] 1618-1298
  • [Journal-full-title] European journal of cell biology
  • [ISO-abbreviation] Eur. J. Cell Biol.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / R01 AG018780; United States / NIA NIH HHS / AG / AG18780; United States / NIAMS NIH HHS / AR / AR048523; United States / NIAMS NIH HHS / AR / T32 AR048523-05; None / None / / R01 AG018780-08; United States / NIAMS NIH HHS / AR / T32 AR048523; United States / NIA NIH HHS / AG / R01 AG018780-08; United States / NIAMS NIH HHS / AR / AR048523-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cyclin-Dependent Kinase Inhibitor p21; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; EC 3.5.1.- / Sirt1 protein, mouse; EC 3.5.1.- / Sirt1 protein, rat; EC 3.5.1.- / Sirtuin 1; EC 3.5.1.- / Sirtuins; S88TT14065 / Oxygen
  • [Other-IDs] NLM/ NIHMS88690; NLM/ PMC2656762
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94. Lantsman Y, Tan KS, Morada M, Yarlett N: Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7. Microbiology; 2008 Sep;154(Pt 9):2757-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7.
  • Biochemical characterization enabled the demonstration of several key enzymes that allowed the construction of a metabolic pathway consisting of an incomplete Krebs cycle linked to the oxygen-sensitive enzymes pyruvate : NADP(+) oxidoreductase (PNO), acetate : succinate CoA transferase (ASCT) and succinate thiokinase (STK), which cumulatively are responsible for recycling CoA and generating ATP.
  • The organelle differs from typical aerobic mitochondria in possessing an oxygen-sensitive PNO that can use FAD(+) or FMN(+) as electron acceptor but is inactive with NAD(+), Spinacia oleracea ferredoxin or Clostridium pasteurianum ferredoxin.
  • A second cluster with 56 % sequence similarity to the pyruvate : ferredoxin oxidoreductase (PFOR) from Trichomonas vaginalis was also identified, which is in agreement with the concept that the PNO gene arose through the fusion of a eubacterial gene for PFOR with the gene for NADPH : cytochrome p450 reductase.
  • Based upon the results of this study, the Blastocystis organelle falls into the category of a MLO.
  • [MeSH-minor] Adenosine Triphosphate / biosynthesis. Animals. Citric Acid Cycle. Coenzyme A-Transferases / metabolism. Flavin Mononucleotide / metabolism. Flavin-Adenine Dinucleotide / metabolism. Ketone Oxidoreductases / metabolism. NAD / metabolism. Protozoan Proteins / metabolism. Succinate-CoA Ligases / metabolism

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  • (PMID = 18757809.001).
  • [ISSN] 1350-0872
  • [Journal-full-title] Microbiology (Reading, England)
  • [ISO-abbreviation] Microbiology (Reading, Engl.)
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / NCDDG AI40320
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protozoan Proteins; 0U46U6E8UK / NAD; 146-14-5 / Flavin-Adenine Dinucleotide; 7N464URE7E / Flavin Mononucleotide; 8L70Q75FXE / Adenosine Triphosphate; EC 1.2.- / Ketone Oxidoreductases; EC 1.2.1.51 / pyruvate dehydrogenase (NADP+); EC 2.8.3.- / Coenzyme A-Transferases; EC 2.8.3.- / acetate-succinate CoA-transferase; EC 6.2.1.- / Succinate-CoA Ligases
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95. Deganuto M, Pittis MG, Pines A, Dominissini S, Kelley MR, Garcia R, Quadrifoglio F, Bembi B, Tell G: Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress. J Cell Physiol; 2007 Jul;212(1):223-35
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  • Gaucher disease (GD) is a lysosomal storage disorder, due to glucosylceramide (GlcCer) accumulation in several body tissues, which causes cellular failure by yet unidentified mechanisms.
  • The ROS rise is probably due to NAD(P)H oxidase activity, being inhibited by the treatment with diphenylene iodonium chloride.


96. de la Lastra CA, Villegas I, Sánchez-Fidalgo S: Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications. Curr Pharm Des; 2007;13(9):933-62
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  • Poly(ADP-ribose) polymerase (PARP) comprise of a family of enzymes which catalyses poly(ADP-ribosyl)ation of DNA-binding proteins.
  • PARP-1, the best characterised member, works as a DNA damage nick-sensor protein that uses beta-NAD(+) to form polymers of ADP-ribose and has been implicated in DNA repair, maintenance of genomic integrity and mammalian longevity.
  • The generation of free radicals, reactive oxygen species, and peroxynitrite causes overactivation of PARP resulting in the depletion of NAD(+) and ATP and consequently in necrotic cell death and organ dysfunction.

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  • (PMID = 17430191.001).
  • [ISSN] 1873-4286
  • [Journal-full-title] Current pharmaceutical design
  • [ISO-abbreviation] Curr. Pharm. Des.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Enzyme Inhibitors; 0 / Hypoglycemic Agents; 0 / Poly(ADP-ribose) Polymerase Inhibitors; 0 / Protective Agents; 0 / Protein Subunits; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases
  • [Number-of-references] 375
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97. Grasberger H, De Deken X, Miot F, Pohlenz J, Refetoff S: Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor. Mol Endocrinol; 2007 Jun;21(6):1408-21
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  • Dual oxidase 2 (DUOX2), a reduced NAD phosphate:O2 oxidoreductase flavoprotein, is a component of the thyrocyte H2O2 generator required for hormone synthesis at the apical plasma membrane.
  • D506N displays a partial deficiency phenotype with reduced surface expression of a mutant protein with normal intrinsic activity in generating H2O2.
  • DUOXA2 may thus be part of a secondary quality control system specific for DUOX2.

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  • (PMID = 17374849.001).
  • [ISSN] 0888-8809
  • [Journal-full-title] Molecular endocrinology (Baltimore, Md.)
  • [ISO-abbreviation] Mol. Endocrinol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK15070; United States / NIDDK NIH HHS / DK / DK20595; United States / NCRR NIH HHS / RR / RR00055
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DUOXA2 protein, human; 0 / DUOXA2 protein, rat; 0 / Flavoproteins; 0 / Membrane Proteins; 0 / Polysaccharides; BBX060AN9V / Hydrogen Peroxide; EC 1.6.3.1 / DUOX2 protein, human; EC 1.6.3.1 / NADPH Oxidase; EC 3.2.1.96 / Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
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98. Arita M, Oh SF, Chonan T, Hong S, Elangovan S, Sun YP, Uddin J, Petasis NA, Serhan CN: Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. J Biol Chem; 2006 Aug 11;281(32):22847-54
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  • With NAD+ as a cofactor, recombinant 15-hydroxyprostaglandin dehydrogenase acted as an 18-hydroxyl dehydrogenase to form 18-oxo-RvE1.
  • At a concentration where RvE1 potently reduced polymorphonuclear leukocyte (PMN) recruitment in zymosan-induced peritonitis, 18-oxo-RvE1 was devoid of activity.
  • These results established the structure of a novel RvE1 initial metabolite, indicating that conversion of RvE1 to the oxo product represents a mode of RvE1 inactivation.

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  • (PMID = 16757471.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-074448; United States / NIDCR NIH HHS / DE / P50-DE-016191
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid; 0 / Anti-Inflammatory Agents; 0 / Cytokines; 0 / Recombinant Proteins; AAN7QOV9EA / Eicosapentaenoic Acid; EC 1.1.1.- / Hydroxyprostaglandin Dehydrogenases; EC 1.1.1.141 / 15-hydroxyprostaglandin dehydrogenase
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99. Suzuki J, Iwai M, Mogi M, Oshita A, Yoshii T, Higaki J, Horiuchi M: Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation. Arterioscler Thromb Vasc Biol; 2006 Apr;26(4):917-21
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  • Production of superoxide anion and expression of NAD(P)H oxidase subunit p47phox, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 in the aorta were increased with the high-cholesterol diet.

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  • (PMID = 16424347.001).
  • [ISSN] 1524-4636
  • [Journal-full-title] Arteriosclerosis, thrombosis, and vascular biology
  • [ISO-abbreviation] Arterioscler. Thromb. Vasc. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ccl2 protein, mouse; 0 / Chemokine CCL2; 0 / Cholesterol, Dietary; 0 / Tetrazoles; 0 / Tumor Necrosis Factor-alpha; 11062-77-4 / Superoxides; 27O7W4T232 / Spironolactone; 4964P6T9RB / Aldosterone; 6995V82D0B / eplerenone; 80M03YXJ7I / Valsartan; EC 1.6.3.1 / NADPH Oxidase; EC 1.6.3.1 / neutrophil cytosolic factor 1; HG18B9YRS7 / Valine
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100. Zhang Q, Hrmova M, Shirley NJ, Lahnstein J, Fincher GB: Gene expression patterns and catalytic properties of UDP-D-glucose 4-epimerases from barley (Hordeum vulgare L.). Biochem J; 2006 Feb 15;394(Pt 1):115-24
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  • Heterologous expression of a near full-length cDNA confirmed that HvUGE1 encodes a functional UGE.
  • A non-covalently bound NAD+ was released from the enzyme after denaturing with aqueous ethanol and was identified by its spectrophotometric properties and by electrospray ionization MS.

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  • (PMID = 16266295.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AY943954/ AY943955/ AY943956
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 5.1.3.- / Carbohydrate Epimerases
  • [Other-IDs] NLM/ PMC1386009
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