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1. Haenssle HA, Krueger U, Vente C, Thoms KM, Bertsch HP, Zutt M, Rosenberger A, Neumann C, Emmert S: Results from an observational trial: digital epiluminescence microscopy follow-up of atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in detecting melanoma. J Invest Dermatol; 2006 May;126(5):980-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Results from an observational trial: digital epiluminescence microscopy follow-up of atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in detecting melanoma.
  • We analyzed the value of digital epiluminescence microscopy (DELM) for the long-term follow-up of atypical nevi.
  • Patients (n=530) were prospectively categorized into defined melanoma risk groups and followed by clinical and epiluminescence microscopy (ELM) examinations.
  • Atypical nevi (n=7001) were additionally followed by DELM.
  • The chance of success for melanoma detection among lesions suspicious by ELM criteria was increased to 17% when additional DELM-documented changes were present.
  • Excisions due to mere DELM changes detected 66.7% of melanomas in familial atypical mole and multiple melanoma (FAMMM) and 32.5% of melanomas in atypical mole syndrome (AMS) patients.
  • We conclude that DELM is a valuable tool for the long-term follow-up of atypical nevi, especially in the high-risk groups of FAMMM and AMS patients.
  • [MeSH-major] Image Processing, Computer-Assisted. Melanoma / diagnosis. Microscopy. Nevus, Pigmented / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 16514414.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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2. Blokesch M, Schoolnik GK: The extracellular nuclease Dns and its role in natural transformation of Vibrio cholerae. J Bacteriol; 2008 Nov;190(21):7232-40
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  • [Title] The extracellular nuclease Dns and its role in natural transformation of Vibrio cholerae.
  • In this study, we investigate how Vibrio cholerae's two extracellular nucleases, Xds and Dns, influence its natural transformability.
  • We show that in the absence of Dns, transformation frequencies are significantly higher than in its presence.
  • During growth on a chitin surface, an increase in transformation efficiency was found to correspond in time with increasing cell density and the repression of dns expression by the quorum-sensing regulator HapR.
  • In contrast, at low cell density, the absence of HapR relieves dns repression, leading to the degradation of free DNA and to the abrogation of the transformation phenotype.

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  • (PMID = 18757542.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI053706; United States / NIAID NIH HHS / AI / AI053706
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 1398-61-4 / Chitin; EC 3.1.- / Deoxyribonucleases
  • [Other-IDs] NLM/ PMC2580679
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3. Bhandary SK, Kamath P SD: Study of relationship of concha bullosa to nasal septal deviation and sinusitis. Indian J Otolaryngol Head Neck Surg; 2009 Sep;61(3):227-9

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  • OBJECTIVES: To study the etiological role of concha bollosa in deviated nasal septum (DNS) and sinusitis.
  • MATERIALS AND METHODS: In this retrospective study 419 consecutive CT scans of paranasal sinuses done between October 2005 and September 2007 were serially evaluated for the presence of concha, DNS and sinusitis.
  • Among these, concha co-existent DNS was found in 87.5%, air column between DNS and concha was found in 88.5% and sinus disease was present in 69.2% of patients.
  • CONCLUSION: Presence of air column between DNS and concha excludes the etiological role of concha in DNS.

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  • (PMID = 23120641.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3449981
  • [Keywords] NOTNLM ; Air column / Concha bullosa / Deviated nasal septum (DNS) / Sinusitis
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4. Nielsen K, Harbst K, Måsbäck A, Jönsson G, Borg A, Olsson H, Ingvar C: Swedish CDKN2A mutation carriers do not present the atypical mole syndrome phenotype. Melanoma Res; 2010 Aug;20(4):266-72
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  • [Title] Swedish CDKN2A mutation carriers do not present the atypical mole syndrome phenotype.
  • Phenotypic characteristics were examined in melanoma-prone southern Swedish CDKN2A (p16-113insArg/p14ARF-128insSer) mutation families, in relation to the CDKN2A genotype, nevi, clinically atypical nevi (CAN) and melanoma.
  • Individuals from eight melanoma-prone families, with index patients carrying the CDKN2A mutation, were offered skin examinations and genotyping (CDKN2A and MC1R).
  • A significant correlation to CAN (P=0.01) and red hair colour (P=0.02) could be confirmed in melanoma patients.
  • A positive mutation status (CDKN2A) was correlated to one or more CAN (P=0.007) but neither to blue eyes, red hair colour, heavy freckling nor high number of nevi.
  • For mutation carriers, median total naevus count was 24 and interquartile range was 12-47 (mean 31); whereas for the whole cohort, median total naevus count was 12 and interquartile range was 5-25 (mean 22).
  • No participant fulfilled the atypical mole syndrome phenotype criteria.
  • Melanomas were diagnosed only in mutation carriers, and melanoma diagnosis was statistically correlated to the presence of one or more CAN and red hair colour, supporting the possible synergistic effect of a MC1R mutation on increased risk of melanoma in patients with a CDKN2A mutation.
  • Family history, with verified tumour diagnoses, remains an important clinical tool for finding mutation carriers for referral to clinical geneticists and simultaneous presence of CAN in probable mutation carriers might strengthen this indication.
  • The atypical mole syndrome phenotype was, however, not verified in the studied families and total naevus counts were low.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Dysplastic Nevus Syndrome / genetics. Germ-Line Mutation. Melanoma / genetics. Skin Neoplasms / genetics

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  • (PMID = 20526219.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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5. Kluger N, Thomas L: The dragon with atypical mole syndrome. Arch Dermatol; 2008 Jul;144(7):948-9
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  • [Title] The dragon with atypical mole syndrome.
  • [MeSH-major] Dysplastic Nevus Syndrome / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis. Tattooing / adverse effects

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  • (PMID = 18645155.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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6. Coolidge T, Heima M, Johnson EK, Weinstein P: The Dental Neglect Scale in adolescents. BMC Oral Health; 2009 Jan 05;9:2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The Dental Neglect Scale (DNS) has been found to be a valid measure of dental neglect in samples of children and adults, and may be valid for adolescents as well.
  • We administered the DNS to a sample of adolescents and report on the relationships between the DNS and oral health status, whether or not the adolescent has been to the dentist recently for routine check-ups, and whether or not the adolescent currently goes to a dentist.
  • We also report the internal and test-retest reliabilities of the DNS in this sample, as well as the results of an exploratory factor analysis.
  • METHODS: One hundred seventeen adolescents from seven youth groups in the Seattle-Tacoma metropolitan area (Washington State, U.S.) completed the DNS and indicated whether they currently go to a dentist, while parents indicated whether the adolescent had a check-up in the previous three years.
  • T-tests were used to compare DNS scores of adolescents who have visible caries or not, adolescents who have had a check-up in the past three years or not, and adolescents who currently go to a dentist or not.
  • RESULTS: In each comparison, significantly higher DNS scores were observed in adolescents with visible caries, who have not had a check-up in the past three years, or who do not go to a dentist (all p values < 0.05).
  • The test-retest reliability of the DNS was high (ICC = 0.81), and its internal reliability was acceptable (Cronbach's alpha = 0.60).
  • CONCLUSION: The DNS appears to operate similarly in this sample of adolescents as it has in other samples of children and adults.

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  • (PMID = 19123953.001).
  • [ISSN] 1472-6831
  • [Journal-full-title] BMC oral health
  • [ISO-abbreviation] BMC Oral Health
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / K23 DE016952; United States / NIDCR NIH HHS / DE / T32 DE007132; United States / NIDCR NIH HHS / DE / U54 DE014254
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2627830
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7. Oh BK, Kim YJ, Park C, Park YN: Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am J Pathol; 2005 Jan;166(1):73-80
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  • The transcriptional expression of these genes, TRF1 protein, and telomere length was examined in 9 normal livers, 14 chronic hepatitis, 24 liver cirrhosis, 5 large regenerative nodules, 14 low-grade dysplastic nodules (DNs), 7 high-grade DNs, 10 DNs with hepatocellular carcinoma (HCC) foci, and 31 HCCs.
  • The expression of TRF1, TRF2, TIN2 mRNA, and TRF1 protein was gradually increased according to the progression of hepatocarcinogenesis with a marked increase in high-grade DNs and DNs with HCC foci and a further increase in HCCs.
  • There was a gradual shortening of telomere during hepatocarcinogenesis with a significant reduction in length in DNs.
  • This was more evident in DNs and DNs with HCC foci.

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  • (PMID = 15632001.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Complementary; 0 / TINF2 protein, human; 0 / Telomere-Binding Proteins; 0 / Telomeric Repeat Binding Protein 1; 0 / Telomeric Repeat Binding Protein 2
  • [Other-IDs] NLM/ PMC1602303
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8. Höglinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, Degregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S: The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A; 2007 Feb 27;104(9):3585-90
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  • [Title] The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease.
  • The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia nigra of patients with Parkinson's disease (PD) are not completely understood.
  • We further demonstrate that the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine injected into mice and application of its active metabolite 1-methyl-4-phenylpyridinium to mesencephalic cultures activate the retinoblastoma-E2F pathway in postmitotic DNs.
  • We also find that cell death rather than mitotic division followed the toxin-induced replication of DNA, as determined by BrdU incorporation in DNs.
  • In addition, blocking E2F-1 transcription protected cultured DNs against 1-methyl-4-phenylpyridinium toxicity.
  • Instead, our results demonstrate that mitosis-like signals are activated in mature DNs in patients with PD and mediate neuronal death in experimental models of the disease.

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  • (PMID = 17360686.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA077314-09; United States / NCI NIH HHS / CA / R01 CA077314; United States / NCI NIH HHS / CA / R01 CA077314-09; United States / NIMH NIH HHS / MH / R24 MH 68855; United States / NIMH NIH HHS / MH / R24 MH068855
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / E2F1 Transcription Factor; 0 / E2f1 protein, mouse; 0 / Oligonucleotides, Antisense; 9P21XSP91P / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; R865A5OY8J / 1-Methyl-4-phenylpyridinium
  • [Other-IDs] NLM/ PMC1805567
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9. Bragg JW, Swindle L, Halpern AC, Marghoob AA: Agminated acquired melanocytic nevi of the common and dysplastic type. J Am Acad Dermatol; 2005 Jan;52(1):67-73
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  • [Title] Agminated acquired melanocytic nevi of the common and dysplastic type.
  • We previously reported a single case of agminated acquired melanocytic nevi, consisting of a localized clustering of banal and atypical moles.
  • We now report 4 more cases, confirming that the initial case was not an isolated finding.
  • We examined the lesions clinically, with a dermoscope, with a Wood's light, and in 3 cases with UV photography so as to exclude nevus spilus from the differential diagnosis.
  • The presence of an underlying dysplastic nevus syndrome phenotype in 4 of the 5 cases raises the possibility that agminated nevi arise as a consequence of postzygotic loss of heterozygosity and, thus, may represent a type 2 segmental manifestation of the atypical mole syndrome phenotype.
  • [MeSH-major] Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 15627083.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Newton Bishop JA, Gruis NA: Genetics: what advice for patients who present with a family history of melanoma? Semin Oncol; 2007 Dec;34(6):452-9
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  • [Title] Genetics: what advice for patients who present with a family history of melanoma?
  • A significantly increased susceptibility to melanoma may manifest as a family history of melanoma (plus or minus pancreatic cancer), the development of multiple primary tumors, or melanoma in the context of numerous and clinically atypical moles (the atypical mole syndrome).
  • Melanoma is causally related to sun exposure in the majority of patients, although the patterns of sun exposure, which are most important, remain controversial.
  • [MeSH-major] Genetic Counseling. Genetic Testing. Melanoma / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Dysplastic Nevus Syndrome / genetics. Genes, p16. Genetic Predisposition to Disease. Humans. Models, Genetic. Pedigree. Skin Pigmentation / genetics

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  • (PMID = 18083368.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA-083115-06
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
  • [Number-of-references] 76
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11. Lange JR, Balch CM: Screening for cutaneous melanoma. Surg Oncol Clin N Am; 2005 Oct;14(4):799-811
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Screening for cutaneous melanoma.
  • Current data do not support widespread population-based screening for melanoma.
  • While the incidence of melanoma is high, the overall mortality is low, and thus any potential benefit of screening the general population is hard to demonstrate.
  • Efforts should be focused on populations at particularly high risk of developing melanoma and on those at high risk of death from melanoma once diagnosed.
  • Persons in kindreds of familial melanoma, and persons who have atypical mole syndrome, those who have a prior diagnosis of melanoma, or those who have diagnosed atypical nevi are all reasonable candidates for routine screening, based on lower-level evidence in the absence of randomized clinical trials targeting these groups.
  • Programs targeting persons of low socioeconomic status and targeting white men over the age of 50 could address groups known to beat especially high risk of melanoma mortality.
  • [MeSH-major] Melanoma / diagnosis. Melanoma / prevention & control. Skin Neoplasms / diagnosis. Skin Neoplasms / prevention & control

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  • (PMID = 16226692.001).
  • [ISSN] 1055-3207
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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12. Celebi JT, Ward KM, Wanner M, Polsky D, Kopf AW: Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome. Clin Exp Dermatol; 2005 Jan;30(1):68-70
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  • [Title] Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome.
  • Atypical mole syndrome is a sporadic or an inherited condition with an increased risk of melanoma.
  • Germline mutations in the CDKN2A, ARF, CDK4 and somatic mutations in the PTEN and BRAF genes have been associated with melanoma.
  • In this study, we evaluated genes associated with familial and sporadic melanoma for mutations in 28 probands with the atypical mole syndrome.
  • These data suggest that genes evaluated in this study are unlikely to be candidate genes for atypical mole syndrome and support the notion that unknown susceptibility gene/s for this disease exist.
  • [MeSH-major] Dysplastic Nevus Syndrome / genetics. Germ-Line Mutation / genetics. Melanoma / genetics. Middle Aged. Skin Neoplasms / genetics

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  • (PMID = 15663508.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 2.7.11.22 / Cyclin-Dependent Kinases; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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13. Pho L, Grossman D, Leachman SA: Melanoma genetics: a review of genetic factors and clinical phenotypes in familial melanoma. Curr Opin Oncol; 2006 Mar;18(2):173-9
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  • [Title] Melanoma genetics: a review of genetic factors and clinical phenotypes in familial melanoma.
  • PURPOSE OF REVIEW: The clinical phenotypes of familial melanoma syndromes and genetic and environmental interactions are reviewed to summarize the current status of the field and to identify gaps in molecular and clinical investigations.
  • RECENT FINDINGS: The familial melanoma syndromes are associated with germline mutations in three highly penetrant gene products: p16, alternate reading frame, and cyclin-dependent kinase 4.
  • Certain variants in a low-penetrance gene, MC1R, the melanocortin 1 receptor gene, increase melanoma risk to a lesser extent and act as a genetic modifier when cosegregating with a deleterious p16 gene.
  • The penetrance of these melanoma-predisposing genes is largely influenced by ultraviolet exposure across geographic latitude.
  • Yet cumulative studies are conflicting on whether ultraviolet radiation, including sunburns, early childhood and adolescent sun exposure, and chronic exposure, increases melanoma risk in familial melanoma.
  • To date, the clinical phenotypes of increased number of atypical nevi and nevi body distribution are independent risk factors for melanoma risk, regardless of family history.
  • The atypical mole syndrome cannot reliably predict melanoma germline mutations but increases melanoma risk in p16 mutation carriers.
  • Familial melanoma patients develop melanomas earlier and are prone to developing multiple primary melanomas.
  • Other than these two differences, familial and sporadic melanoma share similar histopathology, prognostic factors, and survival rates.
  • SUMMARY: Familial melanoma is an excellent human model system for the investigation of melanoma.
  • Understanding genotype-phenotype and environmental relationships in familial melanoma will likely lead to improved understanding of pathogenesis for all melanoma patients.
  • [MeSH-major] Melanoma / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Cyclin-Dependent Kinase 4 / genetics. Genes, Tumor Suppressor. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Nevus / epidemiology. Nevus / genetics. Phenotype. Receptor, Melanocortin, Type 1 / genetics. Risk Factors. Skin Pigmentation / genetics. Sunlight / adverse effects

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  • (PMID = 16462187.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Melanocortin, Type 1; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
  • [Number-of-references] 78
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14. Rigel DS: Epidemiology of melanoma. Semin Cutan Med Surg; 2010 Dec;29(4):204-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology of melanoma.
  • Malignant melanoma represents a significant and growing public health burden in the US and worldwide.
  • It is estimated that 68, 130 cases of invasive malignant melanoma and at least 48,000 cases of melanoma in-situ will be diagnosed in the US this year.
  • Melanoma is also one of the few remaining cancers with increasing US incidence.
  • In the 1930s, the lifetime risk of an American developing invasive malignant melanoma was 1 in 1,500.
  • Deaths from malignant melanoma are also increasing.
  • The mortality rate from malignant melanoma has risen about 2% annually since 1960.
  • The identification of individuals at high risk for malignant melanoma is important for the development of focused and efficient prevention efforts.
  • Acute sun exposure resulting in sunburn remains a significant risk factor for the development of melanoma, but numerous other potential risk factors have been cited.
  • Included among these are atypical mole syndrome/dysplastic nevus syndrome, blistering sunburns, immunosuppression, prior therapy with psoralen with ultraviolet A light (UVA) light, UV exposure at tanning salons, elevated socioeconomic status, and history of melanoma in a first-degree relative.
  • With a better understanding of the reasons for the increasing rate of this cancer, and with enhanced early detection approaches, we may be able to decrease the incidence and mortality of malignant melanoma.
  • [MeSH-major] Melanoma / epidemiology. Skin Neoplasms / epidemiology. Sunlight / adverse effects
  • [MeSH-minor] Dysplastic Nevus Syndrome / complications. Humans. Immunosuppression / adverse effects. Incidence. PUVA Therapy / adverse effects. Pedigree. Risk Factors. Social Class. Sunburn / complications. Ultraviolet Rays / adverse effects. United States / epidemiology

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  • [Copyright] Copyright © 2010. Published by Elsevier Inc.
  • (PMID = 21277533.001).
  • [ISSN] 1558-0768
  • [Journal-full-title] Seminars in cutaneous medicine and surgery
  • [ISO-abbreviation] Semin Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Haenssle HA, Korpas B, Hansen-Hagge C, Buhl T, Kaune KM, Johnsen S, Rosenberger A, Schön MP, Emmert S: Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors. Arch Dermatol; 2010 Mar;146(3):257-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors.
  • OBJECTIVE: To identify patients at increased melanoma risk who benefit from long-term surveillance with digital dermoscopy.
  • PARTICIPANTS: Six hundred eighty-eight patients prospectively categorized into defined melanoma risk groups and followed up (mean, 44.3 months) by clinical examinations, dermoscopy, and, for atypical nevi, sequential digital dermoscopy.
  • RESULTS: Odds ratios from a multivariate logistic regression analysis indicated a highly increased melanoma risk for patients with familial atypical mole and multiple melanoma (FAMMM) syndrome, atypical mole syndrome (AMS), or previous melanoma.
  • Each digitally documented atypical lesion (range, 1-17 lesions per patient) denoted a significant 10% increase in melanoma risk.
  • Patients with higher melanoma risk (1) showed a higher percentage of melanomas detected by digital dermoscopy (FAMMM syndrome group, 50%; AMS group, 22%), (2) more often developed multiple melanomas within shorter intervals, and (3) showed a ratio of melanoma to benign results for lesions excised because of dynamic changes of 1:15 (AMS group) or 1:4 (FAMMM syndrome group).
  • CONCLUSIONS: We suggest an individualized surveillance plan, with digital dermoscopy performed at follow-up intervals of 3 months for patients with FAMMM syndrome and 6 to 12 months (depending on additional risk factors) for those with AMS.
  • Patients with multiple common nevi and no additional risk factors had no benefit from sequential digital dermoscopy.
  • [MeSH-major] Dermoscopy / methods. Image Processing, Computer-Assisted / methods. Melanoma / diagnosis. Patient Selection. Risk Assessment / methods. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Disease Progression. Female. Follow-Up Studies. Germany / epidemiology. Humans. Incidence. Male. Neoplasm Staging. Odds Ratio. Prevalence. Prospective Studies. Risk Factors. Time Factors

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  • (PMID = 20231495.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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16. Frankenthaler A, Lee M, Seery V, Renzi S, Kinnaman M, Liu V, Friedman E, Atkins MB, Cutaneous Oncology Program: Impact of concomitant immunosuppression on the presentation and prognosis of patients with melanoma. J Clin Oncol; 2009 May 20;27(15_suppl):9070

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of concomitant immunosuppression on the presentation and prognosis of patients with melanoma.
  • : 9070 Background: Melanoma has been reported to be susceptible to immune control.
  • Therefore, we hypothesized that concomitant immune suppression might impact the course of the disease.
  • METHODS: We examined the Beth Israel Deaconess Medical Center Cutaneous Oncology Program database for pts with immune suppression at the time of melanoma diagnosis.
  • In addition, 3 controls matched for age, gender, stage and tumor location were identified for each case and disease outcome was compared between cases and controls.
  • RESULTS: 19 pts were identified with melanoma and concomitant immune suppression in a database of 1820 melanoma pts.
  • Melanoma stages at diagnosis were in situ 1, IB 7, IIA 1, IIB 1, IIIB 3, IIIC 5, and IV 1.
  • Compared to the database as a whole, cases were more likely to be female (84% vs 45%) and have a higher disease stage (42% stage IIIB/C vs 26%).
  • In addition, more cases appeared to have an amelanotic primary (21% vs. 5.4%) or an atypical mole syndrome (21% vs 10.2%).
  • For pts who relapsed, the cases had a shorter disease free interval (DFI) (2.1 vs 9.7 yrs) than the controls.
  • As a consequence, cases appeared more likely to have died of their disease than controls (42% vs 23%) (p=0.10).
  • CONCLUSIONS: Compared to the general melanoma population, pts with concomitant immune suppression appear more likely to be female, have an amelanotic primary or atypical mole syndrome and more advanced disease at presentation.
  • Thus, diagnosis and treatment of a primary melanoma at an early stage appears especially important in an immunosuppressed population.

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  • (PMID = 27962173.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Honzátko A, Cvak J, Vaingátová S, Flieger M: Influence of steric hindrance on enantioseparation of Dns-amino acids and pesticides on terguride based chiral selectors in capillary electrophoresis. J Sep Sci; 2005 May;28(7):673-7
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  • [Title] Influence of steric hindrance on enantioseparation of Dns-amino acids and pesticides on terguride based chiral selectors in capillary electrophoresis.
  • Three urea derivatives of ergoline-based chiral selectors (CSs), differing in the size of the urea side chain, i.e. dimethyl- (CSI), diethyl- (CSII), and diisopropylurea (CSIII), were used to study the effect of steric hindrance on the enantioseparation of dansyl amino acids (Dns-AAs), pesticides, and mandelic acid under condition of capillary electrophoresis (CE) in linear polyacrylamide coated capillaries.
  • The best enantioseparation of Dns-AAs was achieved on CSI.

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  • (PMID = 15912739.001).
  • [ISSN] 1615-9306
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Mandelic Acids; 0 / Pesticides; 21OJT43Q88 / dironyl; E0QN3D755O / Lisuride; NH496X0UJX / mandelic acid
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18. Raza ML, Zeeshan M, Ahmad M, Shaheen F, Simjee SU: Anticonvulsant activity of DNS II fraction in the acute seizure models. J Ethnopharmacol; 2010 Apr 21;128(3):600-5
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  • [Title] Anticonvulsant activity of DNS II fraction in the acute seizure models.
  • DNS II acetone was chosen for further testing in the acute seizure models of epilepsy to study the antiepileptic potential in male mice.
  • MATERIALS AND METHODS: Different doses (60, 65 and 70mg/kg, i.p.) of DNS II acetone fraction of Delphinium nordhagenii was administered 30min prior the chemoconvulsant's injection in the male mice.
  • Moreover, four different doses of DNS II (60, 65, 70 and 100mg/kg, i.p.) were tested in the MES test.
  • RESULTS: The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test.
  • [MeSH-minor] Acetone / therapeutic use. Animals. Delphinium / chemistry. Diazepam / therapeutic use. Male. Melanoma / drug therapy. Mice. Mice, Inbred Strains. Pakistan. Pentylenetetrazole / therapeutic use. Phenytoin / therapeutic use. Picrotoxin / therapeutic use. Ranunculaceae / chemistry. Skin Neoplasms / drug therapy

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20138136.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anticonvulsants; 124-87-8 / Picrotoxin; 1364PS73AF / Acetone; 6158TKW0C5 / Phenytoin; Q3JTX2Q7TU / Diazepam; WM5Z385K7T / Pentylenetetrazole
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19. Giuffrida A, Contino A, Maccarrone G, Messina M, Cucinotta V: The 3-amino-derivative of gamma-cyclodextrin as chiral selector of Dns-amino acids in electrokinetic chromatography. J Chromatogr A; 2009 Apr 24;1216(17):3678-86

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  • [Title] The 3-amino-derivative of gamma-cyclodextrin as chiral selector of Dns-amino acids in electrokinetic chromatography.
  • The enantioseparation of the enantiomeric pairs of 10 Dns derivatives of alpha-amino acids was successfully carried out by using for the first time the 3-amino derivative of the gamma-cyclodextrin.

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  • (PMID = 19124131.001).
  • [ISSN] 1873-3778
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Dansyl Compounds; 0 / gamma-Cyclodextrins; KZJ0BYZ5VA / gamma-cyclodextrin
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20. Maász A, Horvatovich K, Magyari L, Talián Csaba G, Bokor S, Laczy B, Tamaskó M, Molnár D, Wittmann I, Melegh B: [Search for mitochondrial DNA T4291C mutation in Hungarian patients with metabolic syndrome]. Orv Hetil; 2006 Apr 16;147(15):693-6
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  • [Title] [Search for mitochondrial DNA T4291C mutation in Hungarian patients with metabolic syndrome].
  • [Transliterated title] Mitokondriális DNS T4291C mutáció vizsgálata metabolikus szindrómában szenvedo betegekben.
  • INTRODUCTION: Metabolic syndrome affects 15-30 percentage of the population.
  • AIMS: In a recent study metabolic syndrome was shown to be transmitted on maternal lineage in a large family; an uridine to cytidine transition was detected in homoplasmic form at position 4291 of the mitochondrial DNA (mtDNA) which affects the 5' neighboring nucleotide to the anticodon of the isoleucine-tRNA.
  • METHODS: Using specific restriction analysis and direct sequencing for detection of this mutation the authors genotyped 365 DNA samples which were collected from 164 adult and 119 pediatric patients with metabolic syndrome.
  • RESULTS AND CONCLUSIONS: The T4291C mtDNA variant could not be detected in any of these patients suggesting that this alteration is likely rare in the Hungarian metabolic syndrome population.
  • [MeSH-major] DNA, Mitochondrial / genetics. Metabolic Syndrome X / genetics. Point Mutation

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  • (PMID = 16734181.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / RNA, Transfer, Ile; 2ZD004190S / Threonine; K848JZ4886 / Cysteine
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21. Griffith R, Tengnah C: The law and grievance resolution in the workplace: a guide for DNs. Br J Community Nurs; 2009 May;14(5):213-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The law and grievance resolution in the workplace: a guide for DNs.

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  • (PMID = 19421087.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Sáfrány E, Csöngei V, Járomi L, Maász A, Magyari L, Sipeky C, Melegh B: [Mitochondrial DNA and its mutations: new advances in a new field]. Orv Hetil; 2007 May 27;148(21):971-8
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] A mitokondriális DNS és mutációi: újabb ismeretek egy új területen.
  • The number of disease-associated pathologic variants is still expanding; the available knowledge about the entities caused by the abnormalities of the mitochondrial DNA is gradually increasing.

  • MedlinePlus Health Information. consumer health - Mitochondrial Diseases.
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  • (PMID = 17513250.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Number-of-references] 96
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23. Lukács J, Sör E, Bohács A, Tolnay E, Bártfai Z, Várdi-Visy K, Somoskövi A: [Tuberculosis due to multidrug resistant Mycobacterium tuberculosis Beijing genotype identified by DNA fingerprinting: the first case identified in Hungary]. Orv Hetil; 2005 Aug 28;146(35):1833-7
Genetic Alliance. consumer health - Tuberculosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] DNS ujjlenyomat-vizsgálattal azonosított Beijing genotípusú Mycobacterium tuberculosis okozta multidrog rezisztens tuberculosis: az elso Magyarországon igazolt eset.

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  • (PMID = 16187543.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antitubercular Agents
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24. Gyorffy A, Gyorffy B, Molnár B, Tulassay Z: [Hybridization and their application in the DNA array technology]. Orv Hetil; 2005 Jul 3;146(27):1447-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] A hibridizáció es alkalmazása DNS-array rendszerekben.

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  • (PMID = 16089106.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 29
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25. Lázár L, Nagy B, Molvarec A, Rigó J Jr: [Quantity of total cell free and cell free fetal DNA in pregnancies with no complications and with preeclampsia]. Orv Hetil; 2010 May 9;151(19):784-7
MedlinePlus Health Information. consumer health - Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] A vérplazma összes szabad DNS, valamint szabad magzati DNS mennyisége praeeclampsiával szövôdött és szövôdménymentes terhességek esetében.

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  • (PMID = 20427261.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 9007-49-2 / DNA
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26. Pastar Z, Lipozencić J, Kovacević S, Canović S, Didović-Torbarina A, Vukasović A: Neurofibromatosis type 1 associated with dysplastic nevus syndrome. Acta Dermatovenerol Croat; 2009;17(2):118-22
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurofibromatosis type 1 associated with dysplastic nevus syndrome.
  • Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder that primarily affects the development and growth of neural cell tissues.
  • Dysplastic nevus syndrome (DNS) represents multiple atypical nevi associated with polygenetic inheritance pattern and may rarely occur together with NF-1.
  • DNS type A is a marker of increased melanoma risk, while melanoma has been rarely reported in patients with NF-1.
  • We describe a case of NF-1 type A with DNS presenting with multiple neural tumors, cafe-au-lait spots, hamartomas in globus pallidus and pigmented melanocytic iris hamartomas (Lisch nodules).
  • The importance of close follow up of nevi in such patients with NF-1 and DNS for the development of melanoma as well as other NF-1 associated skin disorders and with multidisciplinary approach to other associated diseases is highlighted.
  • [MeSH-major] Dysplastic Nevus Syndrome / complications. Neurofibromatosis 1 / complications


27. Nagy B, Bán Z, Papp Z: [Effect of the DNA isolation method on the results of multiple fluorescent PCR and DNA fragment analysis]. Orv Hetil; 2005 Jul 17;146(29):1539-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] A DNS-izolálási módszer hatá'sa a multiplex fluoreszcens PCR- es DNS-fragmens-analízis eredményeire.

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  • (PMID = 16136775.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 9007-49-2 / DNA
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28. Tóth K, Galamb O, Spisák S, Wichmann B, Sipos F, Leiszter K, Molnár J, Molnár B, Tulassay Z: [Free circulating DNA based colorectal cancer screening from peripheral blood: the possibility of the methylated septin 9 gene marker]. Orv Hetil; 2009 May 24;150(21):969-77
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Szabad DNS-alapú vastagbéldaganat-szurés perifériás vérbol: a metilált szeptin-9 génmarker lehetoségei.

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  • (PMID = 19443305.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; EC 3.6.1.- / GTP Phosphohydrolases; EC 3.6.1.- / SEPT9 protein, human; EC 3.6.1.- / Septins
  • [Number-of-references] 46
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29. Lindberg M, Wilhelmsson S: National public health target awareness of staff at two organisational levels in health care. Health Policy; 2007 Dec;84(2-3):243-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate national public health target awareness at two organisational levels in health care comprising public officials and district nurses (DNs).
  • To determine if the targets were incorporated in county council public health policy documents and if DNs worked in accordance with them.
  • METHOD: Telephone interviews were performed with 21 county council officials and personal interviews were conducted with 54 DNs representing Sweden's 21 health care regions.
  • Two programs mentioned DNs' work.
  • The DNs did not mention the national targets for public health and rarely mentioned targets at the county council level.
  • Their work with prevention included self-care advice, changes in lifestyle, and preventing and relieving consequences of chronic disease.
  • The DNs considered themselves as key persons in this work.

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  • (PMID = 17574700.001).
  • [ISSN] 0168-8510
  • [Journal-full-title] Health policy (Amsterdam, Netherlands)
  • [ISO-abbreviation] Health Policy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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30. Dobie J: Palliative care provision for older people in care homes. Br J Community Nurs; 2010 Apr;15(4):170-6
MedlinePlus Health Information. consumer health - Palliative Care.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There is a paucity of research in relation to district nurses' (DNs) experiences of palliative care provision in adult care homes (CHs) despite their substantial involvement.
  • The aim of this study was to demonstrate the current involvement of DNs in CHs and identify the potential implications for future practice in providing palliative care in this setting.
  • The findings suggested that even experienced DNs, wanted support and education about when to commence palliative care.
  • They also wanted earlier involvement with CH residents who have a life-limiting condition and CH managers were seen as being essential contributors towards planning care.
  • There was concern among DNs as to how the Liverpool Care Pathway could be introduced into CHs with untrained carers and finally, DN alignment to CHs was shown to improve continuity of care for residents and produce more effective partnership working between DNs, general practitioners and CH staff.

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  • (PMID = 20559162.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Xu H, Xie JX, Li X, Yang ZH, Zheng ZZ, Wang B, Wang Z: Perfusion-weighted MRI in evaluating the intranodular hemodynamic characteristics of dysplastic nodules and hepatocellular carcinomas in an experimental rat model. J Magn Reson Imaging; 2008 Jan;27(1):102-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perfusion-weighted MRI in evaluating the intranodular hemodynamic characteristics of dysplastic nodules and hepatocellular carcinomas in an experimental rat model.
  • PURPOSE: To investigate the value of perfusion-weighted MRI in the evaluation of the intranodular hemodynamic characteristics of dysplastic nodules (DNs) and hepatocellular carcinomas (HCCs) in an experimental rat model.
  • MATERIALS AND METHODS: A total of 40 rats with chemically-induced DNs and HCCs were investigated.
  • RESULTS: A total of 20 HCCs and 14 DNs were evaluated.
  • The REmax and slope of DNs were significantly lower than adjacent cirrhotic liver parenchyma.
  • Although the Tp of DNs was delayed two to three seconds compared to adjacent cirrhotic liver, there was no significant difference between them.
  • CONCLUSION: Perfusion-weighted MRI detected the intranodular hemodynamic characteristics of DNs and HCCs in an experimental rat model.
  • DNs were hypovascular compared to cirrhotic liver, while HCCs were markedly hypervascular.
  • [MeSH-minor] Animals. Contrast Media. Disease Models, Animal. Gadolinium DTPA. Hemodynamics. Liver Cirrhosis / pathology. Male. Rats. Rats, Sprague-Dawley

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  • MedlinePlus Health Information. consumer health - MRI Scans.
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  • (PMID = 18022847.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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32. Ooigawa H, Nawashiro H, Fukui S, Otani N, Osumi A, Toyooka T, Shima K: The fate of Nissl-stained dark neurons following traumatic brain injury in rats: difference between neocortex and hippocampus regarding survival rate. Acta Neuropathol; 2006 Oct;112(4):471-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We studied the fate of Nissl-stained dark neurons (N-DNs) following traumatic brain injury (TBI).
  • N-DNs were investigated in the cerebral neocortex and the hippocampus using a rat lateral fluid percussion injury model.
  • In the neocortex, the number of dead neurons at 24 h postinjury was significantly less than that of the observed N-DNs in the earlier phase.
  • Only a few N-DNs increased their pERK immunoreactivity.
  • On the other hand, in the hippocampus the number of dead neurons was approximately the same number as that of the N-DNs, and most N-DNs showed an increased pERK immunoreactivity.
  • These data suggest that not all N-DNs inevitably die especially in the neocortex after TBI.
  • The fate of N-DNs is thus considered to differ depending on brain subfields.
  • [MeSH-minor] Analysis of Variance. Animals. Cell Count / methods. Disease Models, Animal. Extracellular Signal-Regulated MAP Kinases / metabolism. Immunohistochemistry. Male. Rats. Rats, Sprague-Dawley. Staining and Labeling. Statistics, Nonparametric. Survival Rate. Time Factors

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  • (PMID = 16858608.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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33. Kojiro M, Roskams T: Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis; 2005;25(2):133-42
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early hepatocellular carcinoma and dysplastic nodules.
  • It has been established that small, equivocal nodular lesions such as dysplastic nodules (DNs) and small well-differentiated hepatocellular carcinomas (early HCCs) are frequently observed in noncancerous liver tissues resected along with HCCs and in explant cirrhotic livers.
  • DNs are classified into low-grade DNs or high-grade DNs on the basis of cytological and architectural atypia; high-grade DNs show varying degrees of cytological or architectural atypia, or both.
  • Early HCCs are indistinctly nodular and highly differentiated and are frequently difficult to differentiate from high-grade DNs.
  • Although the pathological diagnosis of high-grade DNs and early HCCs is controversial, the presence of tumor cell invasion into the intratumoral portal tracts (stromal invasion) is a helpful clue for differentiating early HCC from high-grade DNs.
  • It is highly suggested that many HCCs occurring in cirrhotic liver arise in DNs and develop to classical HCC in a multistep fashion.
  • [MeSH-minor] Cell Aging. Cell Differentiation. Disease Progression. Hepatocytes / pathology. Humans. Immunohistochemistry. Liver Cirrhosis / pathology. Neoplasm Invasiveness

  • MedlinePlus Health Information. consumer health - Liver Cancer.
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  • (PMID = 15918142.001).
  • [ISSN] 0272-8087
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 81
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34. Høyvoll LR, Lunde K, Li HS, Dahle S, Wentzel-Larsen T, Steinsvåg SK: Effects of an external nasal dilator strip (ENDS) compared to xylometazolin nasal spray. Eur Arch Otorhinolaryngol; 2007 Nov;264(11):1289-94
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to elucidate to what extent ENDS might represent an alternative to decongestive nose sprays (DNS).
  • The effects of DNS (xylometazolin) and ENDS (BreatheRight) on subjective and objective nasal blockage were compared in 89 patients.
  • ENDS significantly increased the MCA and the NCV in the anterior 0.0-3.0 cm of the nose compared to DNS, but had no effect on MCA from 3.0 to 5.4 cm behind the nostrils.
  • In contrast to DNS, ENDS had no effect on the posterior NCV.
  • ENDS and DNS gave comparable increase in nasal inspiratory flow as measured by PNIF, and in the subject's own experience of nasal obstruction.
  • ENDS may represent an alternative to DNS as a measure against nasal blockage.

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  • (PMID = 17530269.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Imidazoles; 0 / Nasal Decongestants; 0 / Reagent Strips; WPY40FTH8K / xylometazoline
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35. Bos E, Löfmark A, Törnkvist L: District nurses' experience of supervising nursing students in primary health care: A pre- and post-implementation questionnaire study. Nurse Educ Pract; 2009 Nov;9(6):361-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Nursing students go through clinical supervision in primary health care settings but district nurses' (DNs) circumstances when supervising them are only briefly described in the literature.
  • The aim of this study was to investigate DNs experience of supervising nursing students before and after the implementation of a new supervision model.
  • Ninety-eight (74%) DNs answered a questionnaire before and 84 (65%) after implementation of the new supervision model.
  • The study showed that DNs in most cases felt that conditions for supervision in the workplace were adequate.
  • Improvements after the implementation of a new model chiefly concerned organisation; more DNs stated that one person had primary responsibility for students' clinical practice, that information packages for supervisors and students were available at the health care centres, and that conditions were in place for increasing the number of students they supervised.
  • DNs also stated that supervisors and students benefited from supervision by more than one supervisor.

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  • (PMID = 19042155.001).
  • [ISSN] 1873-5223
  • [Journal-full-title] Nurse education in practice
  • [ISO-abbreviation] Nurse Educ Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Nakamura K, Zen Y, Sato Y, Kozaka K, Matsui O, Harada K, Nakanuma Y: Vascular endothelial growth factor, its receptor Flk-1, and hypoxia inducible factor-1alpha are involved in malignant transformation in dysplastic nodules of the liver. Hum Pathol; 2007 Oct;38(10):1532-46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vascular endothelial growth factor, its receptor Flk-1, and hypoxia inducible factor-1alpha are involved in malignant transformation in dysplastic nodules of the liver.
  • Dysplastic nodules (DNs) are regarded as a premalignant lesion of hepatocellular carcinoma (HCC).
  • In this study, these vascular changes were examined with respect to vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1), hypoxia inducible factor-1alpha (HIF-1alpha), and CD34, by using 20 surgically resected cases of DNs and 36 cases of conventional HCC.
  • Although sinusoidal capillarization characterized by CD34 expression was found diffusely in HCC, such changes were found mainly in the areas around the portal tracts and also in other areas in DNs (focal in 6 cases, zonal in 7 cases, and extensive distribution in 7 cases).
  • These capillarized areas were frequently associated with unpaired arteries, and the infiltration of neoplastic hepatocytes into the portal tracts and loss of reticulin fibers in DNs, particularly those with a zonal and extensive distribution.
  • VEGF was diffusely expressed in neoplastic hepatocytes of DNs and HCC.
  • Interestingly, Flk-1 and HIF-1alpha were mostly expressed in endothelial cells and neoplastic hepatocytes in the capillarized areas around portal tracts in DNs, respectively.
  • In conclusion, the capillarized areas with increased numbers of unpaired arteries in DNs may represent an early malignant transformation.

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  • (PMID = 17640715.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
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37. Cheng CM, Chu PY, Chuang KH, Roffler SR, Kao CH, Tseng WL, Shiea J, Chang WD, Su YC, Chen BM, Wang YM, Cheng TL: Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems. Cancer Gene Ther; 2009 Jan;16(1):83-90
Hazardous Substances Data Bank. HEMATITE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We developed a non-invasive imaging system to assess the location and persistence of gene expression by anchoring an anti-dansyl (DNS) single-chain antibody (DNS receptor) on the cell surface to trap DNS-derivatized imaging probes.
  • DNS hapten was covalently attached to cross-linked iron oxide (CLIO) to form a 39+/-0.5 nm DNS-CLIO nanoparticle imaging probe.
  • DNS-CLIO specifically bound to DNS receptors but not to a control single-chain antibody receptor.
  • DNS-CLIO (100 microM Fe) was non-toxic to both B16/DNS (DNS receptor positive) and B16/phOx (control receptor positive) cells.
  • Magnetic resonance (MR) imaging could detect as few as 10% B16/DNS cells in a mixture in vitro.
  • Importantly, DNS-CLIO specifically bound to a B16/DNS tumor, which markedly reduced signal intensity.
  • Similar results were also shown with DNS quantum dots, which specifically targeted CT26/DNS cells but not control CT26/phOx cells both in vitro and in vivo.
  • These results demonstrate that DNS nanoparticles can systemically monitor the expression of DNS receptor in vivo by feasible imaging systems.

  • MedlinePlus Health Information. consumer health - MRI Scans.
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  • (PMID = 18802451.001).
  • [ISSN] 1476-5500
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Contrast Media; 0 / Dansyl Compounds; 0 / Ferric Compounds; 0 / Fluorescent Dyes; 0 / Haptens; 1K09F3G675 / ferric oxide
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38. Wilhelmsson S, Lindberg M: Health promotion: facilitators and barriers perceived by district nurses. Int J Nurs Pract; 2009 Jun;15(3):156-63

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Interviews with a purposeful sampling of 54 DNs.
  • RESULTS: The DNs expressed that nursing was the right profession to work with health promotion, and that it was an important task that was done by no one else.
  • They experienced being stuck between disease-oriented and health promotion work and that priorities were wrong.
  • The focus was not on health promotion and the time DNs could spend with health promotion was limited, and instead they had to perform elementary medical tasks.
  • DNs lack support and no one asked or cared about the results from health promotion activities.

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  • (PMID = 19531073.001).
  • [ISSN] 1440-172X
  • [Journal-full-title] International journal of nursing practice
  • [ISO-abbreviation] Int J Nurs Pract
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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39. Wada S, Kanzaki R: Neural control mechanisms of the pheromone-triggered programmed behavior in male silkmoths revealed by double-labeling of descending interneurons and a motor neuron. J Comp Neurol; 2005 Apr 4;484(2):168-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These activities are shown by certain descending interneurons contained in two subsets of DNs, Group-I and -II DNs.
  • However, it is not yet well understood which DNs are directly related to instructing this behavior.
  • In order to understand neural control mechanisms of this programmed behavior, we investigated the morphological relationship between these DNs and the cv1-NMN, which is an index of this programmed behavior.
  • We applied a double-labeling technique combining backfilling of the cv1-NMN and intracellular staining of single DNs.
  • 3D confocal images revealed overlapping regions between the Group-I, -II DNs and the cv1-NMN.
  • Group-IIA and -IID, which showed typical flipflop activities, Group-IIC DNs, which showed phasic excitation, and Group-IB DNs, which showed long-lasting inhibition had many overlapping regions on the cv1-NMNs.
  • Our results indicate that the programmed behavior is instructed by these types of DNs.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15736224.001).
  • [ISSN] 0021-9967
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pheromones
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40. Berón de Astrada M, Tuthill JC, Tomsic D: Physiology and morphology of sustaining and dimming neurons of the crab Chasmagnathus granulatus (Brachyura: Grapsidae). J Comp Physiol A Neuroethol Sens Neural Behav Physiol; 2009 Aug;195(8):791-8
Hazardous Substances Data Bank. BIOTIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study provides a description of SNs and DNs in a second crustacean species, the crab Chasmagnathus.
  • SNs and DNs of the crab arborize extensively in the medulla and the axons project to the midbrain.
  • Upon a light pulse, SNs depolarize and increase the firing rate while DNs hyperpolarize and reduce firing.
  • In contrast, DNs show maximal depolarization to near horizontal e-vector orientations.
  • Yet, we found that the location, morphology and physiology of SNs and DNs of the crab are nearly identical to those described in the crayfish.

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  • [Cites] J Comp Neurol. 2002 Nov 4;453(1):10-21 [12357428.001]
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  • (PMID = 19424704.001).
  • [ISSN] 1432-1351
  • [Journal-full-title] Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
  • [ISO-abbreviation] J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / neurobiotin; 6SO6U10H04 / Biotin
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41. Marsili V, Lupidi G, Berellini G, Calzuola I, Perni S, Cruciani G, Gianfranceschi GL: Interaction of DDSDEEN peptide with N-CAM protein. Possible mechanism enhancing neuronal differentiation. Peptides; 2008 Dec;29(12):2232-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The binding causes a quenching of the Dns-peptide fluorescence emission.
  • Dose- and time-dependent binding of Dns-peptide with N-CAM has been shown.
  • Fluorescence quenching is completely lost if the Dns-peptide is subjected to carboxypeptidase digestion.
  • The Dns-peptide-N-CAM bond has been related to the peptide biological activity probably involved in the promotion of neuronal differentiation.
  • An attempt to recognize a possible N-CAM binding site for Dns-peptide was performed by alignment of N-CAM from various sources with some sequences that have been previously reported as binding sites for the pEDDSDEEN and DDSDEEN peptides.

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  • (PMID = 18852000.001).
  • [ISSN] 0196-9781
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecules; 0 / Oligopeptides; 0 / aspartyl-aspartyl-seryl-aspartyl-glutamyl-glutamyl-asparagine; EC 3.4.17.1 / Carboxypeptidases A
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42. Ku HL, Yang KC, Lee YC, Lee MB, Chou YH: Predictors of carbon monoxide poisoning-induced delayed neuropsychological sequelae. Gen Hosp Psychiatry; 2010 May-Jun;32(3):310-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Carbon monoxide poisoning (COP) commonly results in delayed neuropsychological sequelae (DNS).
  • The aim of the article is to demonstrate the clinical characteristics and potential predictors of COP-induced DNS later.
  • Multiple regression analysis was performed to search for the predictive factors of DNS.
  • Most had attempted suicide (93.0%) using CO, and thirteen developed DNS later.
  • A longer duration of admission, more sessions of hyperbaric oxygen therapy, and positive findings in brain computed tomography (CT) scans were more often found in patients with DNS than those without DNS.
  • The GCS and MMSE scores and positive findings in brain CT scans were associated with the development of DNS but COHb was not.
  • CONCLUSIONS: Our results identified several potential predictors of DNS.
  • This finding may help clinicians understand and treat COP patients efficiently.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20430235.001).
  • [ISSN] 1873-7714
  • [Journal-full-title] General hospital psychiatry
  • [ISO-abbreviation] Gen Hosp Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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43. Hansson A, Arvemo T, Marklund B, Gedda B, Mattsson B: Working together--primary care doctors' and nurses' attitudes to collaboration. Scand J Public Health; 2010 Feb;38(1):78-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The Jefferson Scale of Attitudes toward Physician Nurse Collaboration and the Professional Self-Description Form (PSDF) was used to study a cohort of 600 GPs and DNs in Västra Götaland region.
  • The purpose was to map differences and correlations of attitude between DNs and GPs, between male and female GPs, and between older and younger DNs and GPs.
  • DNs (mean 51.7) were significantly more positive about collaboration than GPs (mean 49.4).
  • DNs scored higher on the PSDF-scale than GPs.
  • CONCLUSIONS: DNs were slightly more positive about collaboration than GPs.
  • A positive attitude towards collaboration did not seem to be a part of the GPs' professional role to the same extent as it is for DNs.
  • DNs seem more confident in their profession than GPs.

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  • (PMID = 19762367.001).
  • [ISSN] 1651-1905
  • [Journal-full-title] Scandinavian journal of public health
  • [ISO-abbreviation] Scand J Public Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
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44. Disler R, Jones A: District nurse role in end-stage COPD: a review. Br J Community Nurs; 2010 Sep;15(9):428-30, 432-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • District Nurses (DNs) are core providers of end-stage care in the community but appear to have little contact with patients suffering from non-malignant diseases, such as chronic obstructive pulmonary disease (COPD).
  • This review found limited literature describing the role of DNs in end-stage COPD care, and the studies that did touch on the subject restricted their discourse to the frequency of interaction.
  • A clear bias of end-of-life services to patients with malignancy was noted, as well as a call for community services to extend care to all end-stage patients regardless of underlying disease.
  • In addition, there was a further call for DNs to apply a more holistic approach to care, as described in the literature.
  • Finally, it was clear that while ongoing community intervention is necessary for end-stage COPD patients, support and training is essential to equip DNs to care for these vulnerable patients.
  • [MeSH-major] Nurse's Role. Public Health Nursing / organization & administration. Pulmonary Disease, Chronic Obstructive / nursing. Terminal Care / organization & administration

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  • (PMID = 20852523.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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45. Wang C, Wang R, Wang D, Ding G, Jiang Z: [The investigation about the influence of deviated nasal septum on the adolescents learning quality]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Oct;24(20):937-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate the incidence rate of deviated nasal septum (DNS) of the young men who are going to join the army, and of the students in key high schools in Jimo, and record their educational background, then analysis the influence of DNS on the youth's learning quality.
  • Investigate the two groups' incidence rate of DNS and make a correlative statistic analyses with their educational background.
  • RESULT: There are 395 young men with DNS, which account 12.8% of the 3085 men, with the educational background of college degree and above account 3.0%; high school diploma 12.4%; junior secondary education 27.5%.
  • One hundred and ninety-four students with DNS in key high schools, which account 7.4, and the subsequent entrance examination results shows, undergraduate students account 14.9%, junior college students and considerable education 32.5%, and graduates 52.6%.
  • CONCLUSION: DNS can influence the learning quality of the adolescent.

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  • (PMID = 21171301.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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46. Xu H, Li X, Xie JX, Yang ZH, Wang B: Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model. Acad Radiol; 2007 Mar;14(3):279-86

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: Forty rats with chemically induced primary hepatic nodules ranging pathologically from regenerative nodules (RNs) to dysplastic nodules (DNs) to HCC were examined with diffusion-weighted imaging.
  • RESULTS: Eight RNs, 16 DNs, 7 well-differentiated HCCs (HCCwell), 11 moderately differentiated HCCs (HCCmod), and 14 poorly differentiated HCCs (HCCpoor) were evaluated.
  • There was no significant difference between RNs and DNs (P > 0.05).
  • Although the ADC values of HCCwell were slightly lower than those of DNs, there was no significant difference between them (P > 0.05).
  • CONCLUSION: Diffusion-weighted magnetic resonance imaging can be useful in characterizing focal hepatic nodular lesions, but ADC values cannot be used efficiently to distinguish HCCwell from DNs.

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  • (PMID = 17307660.001).
  • [ISSN] 1076-6332
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Eyanagi R, Toda A, Ishii Y, Saito H, Soeda S, Shimeno H, Shigematsu H: Antigenicity of sulfanilamide and its metabolites using fluorescent-labelled compounds. Xenobiotica; 2005 Sep;35(9):911-25
Hazardous Substances Data Bank. SULFANILAMIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In other words, 5-dimethylamino-N-(4-aminobenzyl)-naphthalenesulfonamide (DNS-4ABA), 5-dimethylamino-N-(4-hydroxylaminobenzyl)-1-naphthalenesulfonamide (DNS-4HABA) and 5-dimethylamino-N-(4-nitrosobenzyl)-1-naphthalenesulfonamide (DNS-4NSBA) were synthesized as model haptens.
  • When analysed by HPLC, a conjugate of DNS-4HABA and glutathione (GSH) with nucleophilic amino acids had two peaks (P-1 and P-2).
  • FAB-MS and 1H-NMR revealed that the DNS-4HABA-GSH conjugate consisted of sulphinamide and semimercaptal.
  • The reactivity of GSH to DNS-4ABA, DNS-4HABA and DNS-4NSBA was quantified by HPLC using an oxidization system (horseradish peroxidase/H2O2).
  • The results show that production of DNS-4NSBA-GSH-conjugate was four to eight times higher than that of DNS-4HABA-GSH conjugate, but that DNS-4ABA did not bind with GSH.
  • Skin reactions were assessed using guinea pigs, and strong delayed erythema was seen with DNS-4NSBA, which bound most strongly with GSH, whereas weak delayed erythema was seen with DNS-4ABA, which did not bind with GSH.
  • DNS-4HABA enzymatically bound with proteins in rat and guinea pig liver cytosol and microsomal fractions.
  • The proteins that bound to DNS-4HABA were purified by HPLC and then subjected to N-terminal amino acid analysis.
  • When DNS-4HABA or DNS-4NSBA binds to proteins that play important roles in the body, unexpected adverse reactions may occur.

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  • (PMID = 16308284.001).
  • [ISSN] 0049-8254
  • [Journal-full-title] Xenobiotica; the fate of foreign compounds in biological systems
  • [ISO-abbreviation] Xenobiotica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Sulfanilamides; 21240MF57M / sulfanilamide
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48. Yoon MA, Kim SH, Park HS, Lee DH, Lee JY, Han JK, Choi BI: Value of dual contrast liver MRI at 3.0 T in differentiating well-differentiated hepatocellular carcinomas from dysplastic nodules: preliminary results of multivariate analysis. Invest Radiol; 2009 Oct;44(10):641-9
Hazardous Substances Data Bank. Ferumoxides .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of dual contrast liver MRI at 3.0 T in differentiating well-differentiated hepatocellular carcinomas from dysplastic nodules: preliminary results of multivariate analysis.
  • OBJECTIVES: To assess the diagnostic value of dual contrast magnetic resonance imaging (DC-MRI) in the differentiation of well-differentiated hepatocellular carcinomas (WD-HCCs) from dysplastic nodules (DNs) and to determine the significant MRI predictors using univariate and multivariate analyses.
  • MATERIALS AND METHODS: Thirty-two WD-HCCs and 33 DNs in 28 patients who underwent liver transplantation with available histopathology as a gold standard were enrolled in this study.
  • Each variable was initially evaluated using univariate analyses to assess statistically significant MRI findings differentiating HCCs and DNs, then with multivariate logistic regression analysis to find the most predictable MRI findings.
  • RESULTS: Twenty WD-HCCs showed iso- or high SI on precontrast T2W images, whereas 23 DNs showed low SI (P = 0.003).
  • Most DNs showed low SI on post-SPIO T2W (30/33) and T2*W (25/33) images, whereas HCCs tended to show heterogeneous high or high SI (16/32 and 19/32) (P < 0.012).
  • On post-SPIO and pre-Gd T1W GRE images, 28 WD-HCCs showed iso- or high SI, whereas 24 DNs showed low SI (P < 0.001).
  • On AP images, 20 HCCs revealed more than minimal degree of enhancement, whereas 32 DNs did not show any enhancement (P < 0.001).
  • Mean relative arterial enhancement ratio of HCCs (39.4%) was also significantly larger than that of DNs (15.6%) (P = 0.001).
  • On portal images, WD-HCCs tended to show iso- or high SI (n = 21), whereas DNs showed low SI (n = 29) (P < 0.001).
  • Multivariate analysis revealed that a subjective degree of enhancement on AP images and SI on post-SPIO and pre-Gd T1W GRE images were the 2 variables that independently differentiated WD-HCCs from DNs.
  • CONCLUSION: The use of DC-MRI is helpful in the differentiation of WD HCCs and DNs.
  • More specifically, a subjective degree of enhancement on AP images and SI on post-SPIO and pre-Gd T1W GRE images are the 2 variables that independently differentiate WD-HCCs from DNs.

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  • (PMID = 19724237.001).
  • [ISSN] 1536-0210
  • [Journal-full-title] Investigative radiology
  • [ISO-abbreviation] Invest Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Drug Combinations; 0 / Magnetite Nanoparticles; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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49. Chang DC, Lee JT, Lo CP, Fan YM, Huang KL, Kang BH, Hsieh HL, Chen SY: Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning. Undersea Hyperb Med; 2010 Jan-Feb;37(1):23-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning.
  • OBJECTIVES: Delayed neuropsychiatric syndrome (DNS) is characterized by mental impairment, motor dysfunction, dementia, or psychosis that develops between a few days and weeks after acute carbon monoxide (CO) poisoning.
  • There is no current effective treatment for DNS.
  • We applied 8-40 sessions of hyperbaric oxygen therapy (HBO2) to patients with DNS and evaluated its effectiveness.
  • RESULTS: The symptoms of DNS for all patients improved significantly after HBOT.
  • CONCLUSION: Our results suggest that HBO2 decreases the severity of impairment in patients with DNS.
  • Although a large randomized trial is required to address the efficacy of this therapy, therapeutic application of HBO2 may be recommended in patients with DNS after CO poisoning.
  • [MeSH-minor] Adult. Dementia / etiology. Dementia / therapy. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Psychotic Disorders / etiology. Psychotic Disorders / therapy. Syndrome

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  • (PMID = 20369650.001).
  • [ISSN] 1066-2936
  • [Journal-full-title] Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
  • [ISO-abbreviation] Undersea Hyperb Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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50. Oh BK, Kim YJ, Park YN, Choi J, Kim KS, Park C: Quantitative assessment of hTERT mRNA expression in dysplastic nodules of HBV-related hepatocarcinogenesis. Am J Gastroenterol; 2006 Apr;101(4):831-8
MedlinePlus Health Information. consumer health - Liver Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quantitative assessment of hTERT mRNA expression in dysplastic nodules of HBV-related hepatocarcinogenesis.
  • Dysplastic nodules (DNs) appear to be preneoplastic lesions of hepatocellular carcinomas (HCCs).
  • In this study, in order to characterize DNs, hTERT mRNA, hTERT gene dosage, and mRNA for c-myc, a transcriptional activator of hTERT were studied in human multi-step hepatocarcinogenesis.
  • METHODS: Fifty four hepatic nodules including 5 large regenerative nodules, 14 low-grade DNs, 7 high-grade DNs, 11 DNs with HCC foci and 17 HCCs, 23 livers with chronic hepatitis/cirrhosis, and 6 normal livers were examined.
  • RESULTS: The hTERT mRNA levels increased with the progression of hepatocarcinogenesis, and a significant induction in the transition between low- and high-grade DNs was seen.
  • Most high-grade DNs strongly expressed hTERT mRNA at levels similar to those of HCCs.
  • Twenty-one percent of low-grade DNs had high levels of hTERT mRNA, up to those of high-grade DNs and there was no difference in the pathological features between low-grade DNs with and without increased hTERT mRNA levels.
  • CONCLUSIONS: These results suggest that the induction of hTERT mRNA is an important early event and that its measurement by real-time quantitative RT-PCR is a useful tool to detect premalignant/malignant tendencies in hepatic nodules.

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  • [CommentIn] Am J Gastroenterol. 2006 Apr;101(4):839-41 [16635228.001]
  • (PMID = 16494581.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / RNA, Messenger; EC 2.7.7.49 / Telomerase
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51. Chuang KH, Cheng CM, Roffler SR, Lu YL, Lin SR, Wang JY, Tzou WS, Su YC, Chen BM, Cheng TL: Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines. Bioconjug Chem; 2006 May-Jun;17(3):707-14
MedlinePlus Health Information. consumer health - Cancer Chemotherapy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the current study, we examined whether multiple therapeutic agents could be targeted to anti-dansyl single-chain antibodies (DNS scFv) that were anchored on the plasma membrane of cancer cells.
  • Functional DNS scFv could be stably expressed on CT-26 colon cancer cells both in vitro and in vivo.
  • Dansyl moieties were covalently attached to recombinant beta-glucuronidase (betaG) and interleukin 2 (IL-2) via a flexible poly(ethylene glycol) linker to form DNS-PEG-betaG and DNS-PEG-IL-2 conjugates.
  • The conjugates selectively bound CT-26 cells that expressed anti-DNS scFv (CT-26/DNS cells) but not CT-26 cells that expressed control scFv (CT-26/phOx cells).
  • DNS-PEG-betaG preferentially activated a glucuronide prodrug (BHAMG) of p-hydroxy aniline mustard at CT-26/DNS cells in culture and accumulated in subcutaneous CT-26/DNS tumors after intravenous administration.
  • Systemic administration of DNS-PEG-IL-2 or DNS-PEG-betaG and BHAMG significantly delayed the growth of CT-26/DNS but not control CT-26/phOx tumors.
  • Combination treatment with DNS-PEG-betaG and BHAMG followed by DNS-PEG-IL-2 therapy significantly suppressed the growth of CT-26/DNS tumors as compared to either single-agent regimen.
  • These results show that at least two DNS-modified therapeutic agents can be selectively delivered to DNS scFv receptors in vitro and in vivo, allowing combination therapy of DNS scFv-modified tumors.

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  • (PMID = 16704208.001).
  • [ISSN] 1043-1802
  • [Journal-full-title] Bioconjugate chemistry
  • [ISO-abbreviation] Bioconjug. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antineoplastic Agents; 0 / Haptens; 0 / Interleukin-2; 0 / Prodrugs; 30IQX730WE / Polyethylene Glycols; EC 3.2.1.31 / Glucuronidase
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52. Ciferri A: Bond scrambling and network elasticity. Chemistry; 2009 Jul 13;15(28):6920-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dynamic networks (DNs) recently reported in the literature are based on cross-linked supramolecular chains or on covalent chains with reversible bonds.
  • Accordingly, a permanent set of the resting length of DNs should generally be expected and set materials should retain long-range elasticity relative to the set state.
  • However, only a limited set is shown by DNs, implying that a strong memory of the initial network topology assists elastic recovery of the original dimensions.
  • In this respect, DNs show better rubber behavior than typical covalent networks.
  • Consistently with theoretical predictions, this surprising finding suggests that bond scrambling relieves local strain constraints on the fluctuations of networks junctions and favors the recovery of the initial network topology.

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  • (PMID = 19499558.001).
  • [ISSN] 1521-3765
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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53. Cheng AC, Wong AC, Sze AM, Yuen HK: Limited nasal septoplasty by ophthalmologists during endonasal dacryocystorhinostomy: is it safe? Ophthal Plast Reconstr Surg; 2009 Jul-Aug;25(4):293-5
MedlinePlus Health Information. consumer health - Endoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Significant deviated nasal septum (DNS) may preclude the performance of endonasal dacryocystorhinostomy (DCR).
  • The purpose of this study was to investigate the outcomes of limited nasal septoplasty in tackling signficant DNS performed by trained ophthalmologists during endonasal DCR.
  • METHODS: In this retrospective interventional case series, the records of all patients requiring limited nasal septoplasty for significant DNS during endonasal DCR at 2 tertiary ophthalmic centers in Hong Kong during January 2006 to December 2007 were reviewed.
  • CONCLUSIONS: In the hands of trained ophthalmic lacrimal surgeons, limited nasal septoplasty is an effective and safe procedure during endonasal DCR, allowing better exposure of the surgical field in patients with significant DNS.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Female. Follow-Up Studies. Humans. Intraoperative Period. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 19617788.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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54. Nilsson C, Skär L, Söderberg S: Swedish District Nurses' experiences on the use of information and communication technology for supporting people with serious chronic illness living at home--a case study. Scand J Caring Sci; 2010 Jun;24(2):259-65
MedlinePlus Health Information. consumer health - Coping with Chronic Illness.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An electronic messaging program via computers and mobile phones with an Internet connection was used, enabling DNs and the ill people to exchange messages to and from anywhere.
  • The DNs in this study used the program two to four times each week from November 2003 to March 2004.
  • The results showed that the DNs felt that the technology increased accessibility to nursing care through a more direct communication with the ill person meaning that a more trusting relationship could be created.
  • The DNs also experienced that the use of ICT saved working time.
  • [MeSH-major] Chronic Disease / nursing. Communication. Information Services. Nurses / psychology

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  • (PMID = 20030770.001).
  • [ISSN] 1471-6712
  • [Journal-full-title] Scandinavian journal of caring sciences
  • [ISO-abbreviation] Scand J Caring Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
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55. King N, Melvin J, Ashby J, Firth J: Community palliative care: role perception. Br J Community Nurs; 2010 Feb;15(2):91-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Twenty-four district nurses (DNs), 15 CMs and seven other key stakeholders were interviewed.
  • DNs saw themselves as having a pivotal role, often coordinating other services as well as providing hands-on care.
  • CMs agreed with the importance of the DN role, but had doubts about whether DNs had the capacity or skills to provide genuine case management.
  • Organizational change contributed to the defensiveness of many DNs about their role, and to CMs' experiences of suspicion towards theirs.

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  • (PMID = 20220622.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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56. Annenkov SY, Shrira VI: Direct numerical simulation of downshift and inverse cascade for water wave turbulence. Phys Rev Lett; 2006 May 26;96(20):204501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • By means of direct numerical simulations (DNS) based on the integrodifferential Zakharov equation, we study the long-term evolution of nonlinear random water wave fields.
  • For the first time, formation of powerlike Kolmogorov-type spectra corresponding to weak-turbulent inverse cascade is demonstrated by DNS, and the evolution in time of the resulting spectra is quantitatively investigated.
  • The predictions of the statistical theory for water waves, both qualitative (formation of the direct and inverse cascades, self-similar behavior) and quantitative (the spectra exponents, specific shape of self-similar functions, the rate of time evolution) are found to be in good agreement with the DNS results, except for the initial part of the evolution, where the established statistical theory is not applicable yet and the evolution has a much faster time scale.

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  • (PMID = 16803176.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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57. Roffler SR, Wang HE, Yu HM, Chang WD, Cheng CM, Lu YL, Chen BM, Cheng TL: A membrane antibody receptor for noninvasive imaging of gene expression. Gene Ther; 2006 Mar;13(5):412-20
MedlinePlus Health Information. consumer health - Genes and Gene Therapy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Functional membrane-bound anti-dansyl antibodies (DNS receptor) were stably expressed on melanoma cells in vitro and in vivo.
  • A bivalent (DNS)2-diethylenetriaminepentaacetic 111Indium probe specifically bound to cells that expressed DNS receptors but not control scFv receptors.
  • Importantly, the 111In probe preferentially localized to DNS receptors but not control receptors on tumors in mice as assessed by gamma camera imaging.
  • By 48 h after intravenous injection, the uptake of the probe in tumors expressing DNS receptors was 72 times greater than the amount of probe in the blood.
  • [MeSH-minor] Animals. Antibody Specificity. Gene Expression. Genetic Engineering. Genetic Vectors / administration & dosage. Haptens. HeLa Cells. Humans. Indium Radioisotopes. Melanoma, Experimental / metabolism. Mice. Mice, Inbred C57BL. Microscopy, Phase-Contrast. Pentetic Acid. Protein Binding. Receptors, Fc / metabolism. Retroviridae / genetics

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  • (PMID = 16267569.001).
  • [ISSN] 0969-7128
  • [Journal-full-title] Gene therapy
  • [ISO-abbreviation] Gene Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholine; 0 / Haptens; 0 / Indium Radioisotopes; 0 / Phosphatidylcholines; 0 / Receptors, Cell Surface; 0 / Receptors, Fc; 7A314HQM0I / Pentetic Acid
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58. Chumakov SG: A priori study of subgrid-scale flux of a passive scalar in isotropic homogeneous turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2008 Sep;78(3 Pt 2):036313

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We perform a direct numerical simulation (DNS) of forced homogeneous isotropic turbulence with a passive scalar that is forced by mean gradient.
  • The DNS data are used to study the properties of subgrid-scale flux of a passive scalar in the framework of large eddy simulation (LES), such as alignment trends between the flux, resolved, and subgrid-scale flow structures.

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  • (PMID = 18851149.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Perlekar P, Mitra D, Pandit R: Direct numerical simulations of statistically steady, homogeneous, isotropic fluid turbulence with polymer additives. Phys Rev E Stat Nonlin Soft Matter Phys; 2010 Dec;82(6 Pt 2):066313
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We carry out a direct numerical simulation (DNS) study that reveals the effects of polymers on statistically steady, forced, homogeneous, and isotropic fluid turbulence.
  • We also compare our results with recent experiments and earlier DNS studies of decaying fluid turbulence with polymer additives.

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  • (PMID = 21230740.001).
  • [ISSN] 1550-2376
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Suzuki M, Iijima M, Nishimura A, Tomozoe Y, Kamei D, Yamada M: Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence. FEBS J; 2005 Aug;272(15):3975-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The C-terminal 19-residue sequence (SGYGKVSRRGGHQNSYKPY) was identified as an hnRNP D nucleocytoplasmic shuttling sequence (DNS).
  • In vitro nuclear transport using permeabilized cells indicated that nuclear import of DNS is mediated by transportin-1 (Trn-1).
  • DNS accumulation in the nucleus was dependent on Trn-1, Ran, and energy in multiple rounds of nuclear transport.
  • Use of DNS with deletions, alanine scanning mutagenesis and point mutations revealed that two separate regions (the N-terminal seven residues and the C-terminal two residues) are crucial for in vivo and in vitro transport as well as for interaction with Trn-1.

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  • (PMID = 16045768.001).
  • [ISSN] 1742-464X
  • [Journal-full-title] The FEBS journal
  • [ISO-abbreviation] FEBS J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Heterogeneous-Nuclear Ribonucleoprotein D; 0 / Protein Isoforms; 0 / Protein Sorting Signals
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61. Peng W, Chen Y, Fan S, Zhang F, Zhang G, Fan X: Use of 4,4'-dinitrostilbene-2,2'-disulfonic acid wastewater as a raw material for paramycin production. Environ Sci Technol; 2010 Dec 1;44(23):9157-62
Hazardous Substances Data Bank. P-AMINOSALICYLIC ACID .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study uses 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNS) wastewater to produce paramycin (4-amino-2-hydroxybenzoic acid), an antitubercular agent and important pharmaceutical intermediate.
  • The high concentrations of aromatic sulfonic acids contained in the wastewater, derived from a DNS production facility, have been transformed to paramycin in yields of more than 85%.
  • This waste-disposal strategy, which combines oxidation using NaClO, reduction using iron powder, and subsequent alkaline fusion with NaOH, has been proven to be successful in dealing with ton-scale DNS wastewater.
  • This effectively solves the associated environment problems associated with DNS wastewater and is also potentially profitable.

  • Hazardous Substances Data Bank. 4,4'-DINITRO-2,2'-STILBENEDISULFONIC ACID .
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  • (PMID = 21053909.001).
  • [ISSN] 1520-5851
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Stilbenes; 0 / Water Pollutants, Chemical; 128-42-7 / 4,4'-dinitro-2,2'-stilbenedisulfonic acid; 5B2658E0N2 / Aminosalicylic Acid
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62. Kogita S, Imai Y, Okada M, Kim T, Onishi H, Takamura M, Fukuda K, Igura T, Sawai Y, Morimoto O, Hori M, Nagano H, Wakasa K, Hayashi N, Murakami T: Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow. Eur Radiol; 2010 Oct;20(10):2405-13
Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To retrospectively investigate enhancement patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI in relation to histological grading and portal blood flow.
  • METHODS: Sixty-nine consecutive patients with 83 histologically proven HCCs and DNs were studied.
  • RESULTS: Post-contrast EOB ratios significantly decreased as the degree of differentiation declined in DNs (1.00 ± 0.14) and well, moderately and poorly differentiated HCCs (0.79 ± 0.19, 0.60 ± 0.27, 0.49 ± 0.10 respectively).
  • Gd-EOB-DTPA uptake, assessed by EOB enhancement ratios, deceased slightly in DNs and still more in HCCs, while there was no statistical difference in the decrease between different histological grades of HCC.
  • Reductions in portal blood flow were observed less frequently than decreases in Gd-EOB-DTPA uptake in DNs and well-differentiated HCCs.
  • The hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may help estimate histological grading, although difficulties exist in differentiating HCCs from DNs.

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  • (PMID = 20490505.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
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63. Vincent TE, Gendeh BS: The association of concha bullosa and deviated nasal septum with chronic rhinosinusitis in functional endoscopic sinus surgery patients. Med J Malaysia; 2010 Jun;65(2):108-11
MedlinePlus Health Information. consumer health - Sinusitis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chronic rhinosinusitis (CRS) remains a prevalent disease and a major cause of morbidity for many patients and functional endoscopic sinus surgery (FESS) is the gold standard for the treatment of CRS.
  • The data revealed that deviated nasal septum (DNS) and concha bullosa (CB) were the two commonest anatomical variations in the nasal cavity.
  • DNS is also prevalent but has no significant statistical relationship with sex, age, ethnic group in the local context.
  • CB and DNS are coincidental variations and this study disprove that DNS is associated with CB in its development and pathogenesis of CRS.

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  • (PMID = 23756792.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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64. Sullivan KA, McLaughlin D, Hasson F: Exploring district nurses' experience of a hospice at home service. Int J Palliat Nurs; 2005 Sep;11(9):458-66
MedlinePlus Health Information. consumer health - Palliative Care.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: this study surveyed a representative sample of district nurses (DNs) to ascertain their experience of working alongside a HAH service.
  • METHOD: a self-completed postal questionnaire comprised of 14 items was distributed to 128 DNs.
  • However, the need for improved communication and increased awareness among DNs about the HAH service were also identified.
  • CONCLUSION: the findings support the idea that a HAH service can enable patients with advanced progressive disease to be cared for at home.

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  • (PMID = 16215523.001).
  • [ISSN] 1357-6321
  • [Journal-full-title] International journal of palliative nursing
  • [ISO-abbreviation] Int J Palliat Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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65. Koizumi H, Yokoshima S, Fukuyama T: Total synthesis of (-)-morphine. Chem Asian J; 2010 Oct 4;5(10):2192-8
Hazardous Substances Data Bank. MORPHINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Furthermore, mild deprotection conditions to remove the 2,4-dinitrobenzenesulfonyl (DNs) group enabled the facile construction of the morphinan skeleton.
  • We have also established an efficient synthetic route to a cyclohexenol unit containing an N-methyl-DNs-amide moiety.

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  • (PMID = 20715192.001).
  • [ISSN] 1861-471X
  • [Journal-full-title] Chemistry, an Asian journal
  • [ISO-abbreviation] Chem Asian J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Enzymes; 76I7G6D29C / Morphine
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66. Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A: A MicroRNA feedback circuit in midbrain dopamine neurons. Science; 2007 Aug 31;317(5842):1220-4
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We investigated the role of miRNAs in mammalian midbrain dopaminergic neurons (DNs).
  • We identified a miRNA, miR-133b, that is specifically expressed in midbrain DNs and is deficient in midbrain tissue from patients with Parkinson's disease. miR-133b regulates the maturation and function of midbrain DNs within a negative feedback circuit that includes the paired-like homeodomain transcription factor Pitx3.


67. Xu H, Kong X, Xiong Y, Zhang X: MR features of regenerative nodules and dysplastic nodules in the cirrhotic liver. J Huazhong Univ Sci Technolog Med Sci; 2005;25(5):601-3
Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR features of regenerative nodules and dysplastic nodules in the cirrhotic liver.
  • In order to study MR features of the regenerative nodule (RN) and dysplastic nodule (DN) of the cirrhotic liver, 26 cases of cirrhotic liver with RNs and DNs, of which 8 cases accompanied with hepatocellular carcinoma, were subjected to MRI.
  • Among the 14 cases of DNs, 8 cases had nodules measuring 1-3 cm in size and 6 had macroregenerative nodule measuring > 3 cm.
  • In 8 cases with DNs measuring 1-3 cm in size, 5 cases appeared hyperintense on T1WI and hypointense on T2WI as well as the enhancement as that of nodules with < 1 cm in size; and the remaining 3 cases appeared hypointense on T1WI and hyperintense on T2WI, and were not isointense to the surrounding hepatic parenchyma on enhanced MRI but hyperintense on SPIO enhanced MRI.
  • It was suggested that RNs of cirrhosis had features on MRI that usually allow distinction from hepatocellular carcinoma but not always from dysplastic nodules (DNs).
  • A helpful distinction between HCC and DNs is that the latter are almost never hyperintense on T2WI.
  • Additionally, low grade DNs appear hypointense on SPIO enhanced MRI.

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  • (PMID = 16463687.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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68. Gu Y, Xie H, Gao J, Liu D, Williams CT, Murphy CJ, Ploehn HJ: AFM characterization of dendrimer-stabilized platinum nanoparticles. Langmuir; 2005 Mar 29;21(7):3122-31
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  • This work describes the use of atomic force microscopy (AFM) to measure the size of dendrimer-stabilized Pt nanoparticles (Pt DNs) deposited from aqueous solutions onto mica surfaces.
  • Despite considerable previous work in this area, we do not fully understand the mechanisms by which PAMAM dendrimers template the formation of Pt DNs.
  • We show that AFM height measurements can distinguish between "empty" PAMAM and Pt DNs.
  • The surface density of features in AFM images suggest that these Pt DNs reside on the mica surface as two-dimensional surface aggregates.
  • These observations are consistent with an intradendrimer templating mechanism for Pt DNs.
  • Also considering the magnitudes of the measured mean height values, the data suggest that Pt DNs exist as ramified, noncompact aggregates of Pt atoms interspersed within the PAMAM framework.

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  • (PMID = 15779994.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Guido M, Roskams T, Pontisso P, Fassan M, Thung SN, Giacomelli L, Sergio A, Farinati F, Cillo U, Rugge M: Squamous cell carcinoma antigen in human liver carcinogenesis. J Clin Pathol; 2008 Apr;61(4):445-7
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  • BACKGROUND: Squamous cell carcinoma antigen (SCCA) is a serine protease inhibitor that can be overexpressed in hepatocellular carcinoma (HCC) at both molecular and protein level, but no data are available on its expression in pre-malignant stages.
  • METHODS: 55 nodules from 42 explanted livers were evaluated: 7 large regenerative nodules (LRNs), 7 low-grade dysplastic nodules (LG-DNs), 10 high-grade DNs (HG-DNs), and 31 HCC.
  • The prevalence of SCCA expression was 29% in LRNs, 100% in DNs and 93% in HCC.
  • A significant difference emerged in both prevalence and score for LRNs versus LG-DNs (p<0.039), HG-DNs (p = 0.001), and HCC (p = 0.000).
  • A barely significant difference (p = 0.49) was observed between LG-DNs and HG-DNs, while no difference in SCCA expression was detected between HG-DNs and HCC.

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  • (PMID = 17893121.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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70. Rangari VK, Mohammad GM, Jeelani S, Butenko YV, Dhanak VR: Synthesis and characterization of diamond-coated CNTs and their reinforcement in Nylon-6 single fiber. ACS Appl Mater Interfaces; 2010 Jul;2(7):1829-34
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  • The results show that the DNs were coated on the outer wall surface of CNTs.
  • These results were also compared with Nylon-6 fibers infused with pristine CNTs and pristine DNs.

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  • (PMID = 20557122.001).
  • [ISSN] 1944-8244
  • [Journal-full-title] ACS applied materials & interfaces
  • [ISO-abbreviation] ACS Appl Mater Interfaces
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polymers; 25038-54-4 / nylon 6; 6879X594Z8 / Caprolactam; 7782-40-3 / Diamond
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71. Zidikheri MJ, Frederiksen JS: Stochastic subgrid-scale modelling for non-equilibrium geophysical flows. Philos Trans A Math Phys Eng Sci; 2010 Jan 13;368(1910):145-60

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  • The subgrid dissipation and stochastic forcing covariance matrices as well as the mean subgrid forcing required by the LES model are obtained from the statistics of a high resolution direct numerical simulation (DNS).
  • We show that employing these parametrizations leads to LES in close agreement with DNS.

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  • [Copyright] This journal is © 2010 The Royal Society
  • (PMID = 19948548.001).
  • [ISSN] 1364-503X
  • [Journal-full-title] Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
  • [ISO-abbreviation] Philos Trans A Math Phys Eng Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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72. Zhao Y, Zhong Z: Detection of Hg2+ in aqueous solutions with a foldamer-based fluorescent sensor modulated by surfactant micelles. Org Lett; 2006 Oct 12;8(21):4715-7
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  • [structure: see text] A hybrid foldamer constructed from six cholate units and two methionines was labeled with a DANSYL (DNS) group.

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  • (PMID = 17020285.001).
  • [ISSN] 1523-7060
  • [Journal-full-title] Organic letters
  • [ISO-abbreviation] Org. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fluorescent Dyes; 0 / Micelles; 0 / Solutions; 059QF0KO0R / Water; AE28F7PNPL / Methionine; FXS1BY2PGL / Mercury
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73. Sato K, Kanno J, Tominaga T, Matsubara Y, Kure S: De novo and salvage pathways of DNA synthesis in primary cultured neurall stem cells. Brain Res; 2006 Feb 3;1071(1):24-33
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  • [Title] De novo and salvage pathways of DNA synthesis in primary cultured neurall stem cells.
  • We studied the de novo and salvage pathways of DNA synthesis in sphere-forming neural stem cells obtained from mouse embryos by a neurosphere method.
  • The former pathway needs folic acid (FA) for nucleotide biosynthesis, while the latter requires deoxyribonucleosides (dNS).
  • We examined the proliferative activity of sphere-forming cells in E14.5 embryos by counting the number of spheres formed in media that lacked FA and/or dNS.
  • Proliferation failure and apoptosis occurred in a deficient medium lacking of both FA and dNS.
  • Spheres formed in the deficient medium supplemented with dNS, without FA, did not produce neuron, but rather only seem to generate astrocytes and oligodendrocytes when plated under differentiation condition in culture.
  • Spheres formed in the media containing low dose Azathioprine and methotrexate, inhibitors of de novo DNA synthesis, were selectively prevented from producing neurons even in the presence of FA.
  • These results suggested that activating de novo DNA synthesis was needed for neural stem cells to proliferate with multipotentiality.

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  • (PMID = 16409993.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antimetabolites; 0 / Deoxyribonucleosides; 0 / Enzyme Inhibitors; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Microtubule-Associated Proteins; 0 / Mtap2 protein, mouse; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / O Antigens; 0 / Tubulin; 0 / beta3 tubulin, mouse; 12001-76-2 / Vitamin B Complex; 9007-49-2 / DNA; 935E97BOY8 / Folic Acid; MRK240IY2L / Azathioprine; YL5FZ2Y5U1 / Methotrexate
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74. Mejías R, Villadiego J, Pintado CO, Vime PJ, Gao L, Toledo-Aral JJ, Echevarría M, López-Barneo J: Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice. J Neurosci; 2006 Apr 26;26(17):4500-8
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  • Oxidative damage to dopaminergic nigrostriatal (DNS) neurons plays a central role in the pathogenesis of Parkinson's disease (PD).
  • We have studied in vivo the role of G6PD overexpressed specifically in the DNS pathway and show that the increase of G6PD activity in the soma and axon terminals of DNS neurons, separately from other neurons or glial cells, protects them from parkinsonism.
  • Analysis of DNS neurons by histological, neurochemical, and functional methods showed that even a moderate increase of G6PD activity rendered transgenic mice more resistant than control littermates to the toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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  • (PMID = 16641229.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neuroprotective Agents; 0 / Recombinant Proteins; EC 1.1.1.49 / Glucosephosphate Dehydrogenase; VTD58H1Z2X / Dopamine
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75. Li Y, Meneveau C, Chen S, Eyink GL: Subgrid-scale modeling of helicity and energy dissipation in helical turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2006 Aug;74(2 Pt 2):026310
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Together with the dynamic Smagorinsky model and the dynamic mixed model, they are also tested a posteriori in both decaying and steady isotropic helical turbulence by comparing results to direct numerical simulations (DNS).
  • The a priori tests confirm that the Smagorinsky model underestimates SGS helicity dissipation, although quantitative differences with the predictions are observed due to the finite Reynolds number of the DNS.
  • Within the small differences, the various versions of the dynamic model provide the results closest to the DNS.

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  • (PMID = 17025542.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Kaposi-Novak P, Libbrecht L, Woo HG, Lee YH, Sears NC, Coulouarn C, Conner EA, Factor VM, Roskams T, Thorgeirsson SS: Central role of c-Myc during malignant conversion in human hepatocarcinogenesis. Cancer Res; 2009 Apr 1;69(7):2775-82
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  • [Title] Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.
  • To decode the molecular events during early stages of liver carcinogenesis, we performed gene expression profiling on cirrhotic (regenerative) and dysplastic nodules (DN), as well as eHCC.
  • Although considerable heterogeneity was observed at the regenerative and dysplastic stages, overall, 460 differentially expressed genes were detected between DN and eHCC.
  • Functional analysis of the significant gene set identified the MYC oncogene as a plausible driver gene for malignant conversion of the DNs.
  • Furthermore, a classifier constructed from MYC target genes could robustly discriminate eHCC from high-grade and low-grade DNs.
  • In conclusion, our study identified unique expression patterns associated with the transition of high-grade DNs into eHCC and showed that activation of the MYC transcription signature is strongly associated with the malignant conversion of preneoplastic liver lesions.
  • [MeSH-minor] Disease Progression. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Liver Cirrhosis / genetics. Liver Cirrhosis / metabolism. Liver Cirrhosis / pathology. Neoplasm Staging. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology

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  • (PMID = 19276364.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE12443
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc
  • [Other-IDs] NLM/ NIHMS90884; NLM/ PMC2680077
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77. Hytiroglou P, Theise ND: Telomerase activation in human hepatocarcinogenesis. Am J Gastroenterol; 2006 Apr;101(4):839-41
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Active telomerase is present in the majority of malignant human tumors, including most cases of hepatocellular carcinoma (HCC).
  • Telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, has been found to be expressed in HCCs, dysplastic (precancerous) nodules (DNs), and regenerative nodules arising in cirrhosis.
  • High levels of hTERT mRNA were present in HCCs, high-grade DNs, and occasional low-grade DNs, whereas low levels were found in normal livers, livers with chronic hepatitis B (with or without cirrhosis), large regenerative nodules, and most low-grade DNs.
  • Indeed, emerging data from gene expression analyses of DNs and HCCs suggest that hTERT can be included in sets of select genes that provide "molecular signatures" with utility in the diagnosis and management of nodular hepatic lesions.

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  • [CommentOn] Am J Gastroenterol. 2006 Apr;101(4):831-8 [16494581.001]
  • (PMID = 16635228.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; EC 2.7.7.49 / Telomerase
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78. Wang Y, Ong TT, Li LS, Tan TT, Ng SC: Enantioseparation of a novel "click" chemistry derived native beta-cyclodextrin chiral stationary phase for high-performance liquid chromatography. J Chromatogr A; 2009 Mar 20;1216(12):2388-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A novel native beta-cyclodextrin chiral stationary phase was prepared via "click" chemistry with cuprous iodide-triphenylphosphine complex as the catalyst and applied for enantioseparation of Dns-amino acids, substituted phenyl and phenoxy group modified propionic acids, flavonoids, and some pharmaceutical compounds such as nimodipine, propranolol, brompheniramine and bendroflumethiazide in reversed-phase high-performance liquid chromatography.
  • The resolution of Dns-DL-Leu could reach 5.08 using a mobile phase consisting of 1% (w/w) triethylammonium acetate buffer (pH 4.11) and methanol (50:50 v/v).
  • The effects of buffer pH and the content of organic modifier on enantioseparation of Dns-amino acids by this novel chiral phase were being investigated.

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  • (PMID = 19185873.001).
  • [ISSN] 1873-3778
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Dansyl Compounds; 0 / Flavonoids; 0 / Pharmaceutical Preparations; 0 / Propionates; 0 / beta-Cyclodextrins; JV039JZZ3A / betadex
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79. Lee S, Knight D: District nurses' involvement in mental health: an exploratory survey. Br J Community Nurs; 2006 Apr;11(4):138-42
MedlinePlus Health Information. consumer health - Mental Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The DNs reported encountering a wide range of mental health issues and interventions in practice: dementia, anxiety and depression featured highly.
  • GPs were the most likely person to whom DNs made referrals, followed by community psychiatric nurses.
  • Despite the apparent awareness of the values of psychosocial interventions, DNs were equally influenced by the medical model of treatment.

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  • (PMID = 16723902.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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80. Zhao X, He GW: Space-time correlations of fluctuating velocities in turbulent shear flows. Phys Rev E Stat Nonlin Soft Matter Phys; 2009 Apr;79(4 Pt 2):046316

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The similarity assumptions are justified using the Kolmogorov similarity hypotheses and verified using the direct numerical simulation (DNS) of turbulent channel flows.
  • The DNS of turbulent channel flows supports the prediction: the correlation functions exhibit a fair good collapse, when plotted against the normalized space and time separations defined by the elliptic model.

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  • (PMID = 19518342.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Wolff NL, Weaver RL: Toward a theory of wave energy transport in large irregular structures. J Acoust Soc Am; 2005 Jul;118(1):222-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An ansatz is proposed by which the energy transport behavior observed at early times in a direct numerical simulation (DNS) of a large irregular structure may be extrapolated to arbitrary times.
  • The model is then successfully used to extract diffusion parameters from data obtained in a DNS of a simple undamped two-room structure of a kind typically analyzed by SEA or room acoustics.

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  • (PMID = 16119345.001).
  • [ISSN] 0001-4966
  • [Journal-full-title] The Journal of the Acoustical Society of America
  • [ISO-abbreviation] J. Acoust. Soc. Am.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Kivotides D, Barenghi CF, Mee AJ, Sergeev YA: Interaction of solid particles with a tangle of vortex filaments in a viscous fluid. Phys Rev Lett; 2007 Aug 17;99(7):074501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rather than generating the turbulence by direct numerical simulation (DNS) of the Navier-Stokes equations, we use a model of turbulence based entirely on viscous vortex filaments which interact via inertial forces and reconnect with each other.
  • Using this model, we show that solid particles can become trapped around vortex filaments, something difficult to achieve with DNS.

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  • (PMID = 17930898.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Rocchini D: Algorithmic foundation of spectral rarefaction for measuring satellite imagery heterogeneity at multiple spatial scales. Sensors (Basel); 2009;9(1):303-10

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  • An algorithmic solution of rarefaction applied to image pixel values (Digital Numbers, DNs) is provided and discussed.

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  • [Cites] Ecol Lett. 2006 Aug;9(8):923-32 [16913935.001]
  • (PMID = 22389600.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3280746
  • [Keywords] NOTNLM ; algorithmic solution of rarefaction (major topic) / rarefaction theory (major topic) / satellite imagery (major topic) / spectral heterogeneity (major topic)
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84. Qi XQ, Wen J, Qi ZH: New 3D graphical representation of DNA sequence based on dual nucleotides. J Theor Biol; 2007 Dec 21;249(4):681-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We introduce a 3D graphical representation of DNA sequences based on the pairs of dual nucleotides (DNs).

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  • (PMID = 17931659.001).
  • [ISSN] 0022-5193
  • [Journal-full-title] Journal of theoretical biology
  • [ISO-abbreviation] J. Theor. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 9004-22-2 / Globins; 9007-49-2 / DNA
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85. Modin S, Törnkvist L, Furhoff AK, Hylander I: Family physicians' experiences when collaborating with district nurses in home care-based medical treatment. A grounded theory study. BMC Fam Pract; 2010;11:82
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: This article concerns Swedish family physicians' (FPs) experiences collaborating with district nurses (DNs) when the DNs provide medical treatment for home care patients.
  • RESULTS: It was essential for FPs to collaborate with and rely on DNs in the medical treatment of home care patients.
  • According to the FPs, factors such as the disease, FPs' working conditions and attitude determined how much of the initiative in this treatment FPs retained or left to DNs.
  • Depending on the circumstances, two different roles were adopted by the individual FPs: medical conductors who retain the initiative and medical consultants who leave the initiative to DNs.
  • Factors as the disease, DNs' attitudes towards collaboration and DNs' working conditions influenced whether or not the FPs felt that grounds for relying on DNs were satisfactory.

  • MedlinePlus Health Information. consumer health - Home Care Services.
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  • (PMID = 20979649.001).
  • [ISSN] 1471-2296
  • [Journal-full-title] BMC family practice
  • [ISO-abbreviation] BMC Fam Pract
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2984454
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86. Gaasbeek EJ, Wagenaar JA, Guilhabert MR, van Putten JP, Parker CT, van der Wal FJ: Nucleases encoded by the integrated elements CJIE2 and CJIE4 inhibit natural transformation of Campylobacter jejuni. J Bacteriol; 2010 Feb;192(4):936-41
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • For a subset of strains we previously showed that a periplasmic DNase, encoded by dns, inhibits natural transformation in C. jejuni.
  • In the present study, genetic factors coding for DNase activity in the absence of dns were identified.
  • DNA arrays indicated that nonnaturally transformable dns-negative strains contain putative DNA/RNA nonspecific endonucleases encoded by CJE0566 and CJE1441 of strain RM1221.

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  • (PMID = 20023031.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE18399
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA, Bacterial; 0 / RNA, Bacterial; EC 3.1.- / Deoxyribonucleases
  • [Other-IDs] NLM/ PMC2812962
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87. Gaasbeek EJ, Wagenaar JA, Guilhabert MR, Wösten MM, van Putten JP, van der Graaf-van Bloois L, Parker CT, van der Wal FJ: A DNase encoded by integrated element CJIE1 inhibits natural transformation of Campylobacter jejuni. J Bacteriol; 2009 Apr;191(7):2296-306
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Analysis of CJIE1 indicated the presence of dns (CJE0256), which is annotated as a gene encoding an extracellular DNase.
  • DNase assays using a defined dns mutant and a dns-negative strain expressing Dns from a plasmid indicated that Dns is an endogenous DNase.
  • The DNA-hydrolyzing activity directly correlated with the natural transformability of the knockout mutant and the dns-negative strain expressing Dns from a plasmid.

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  • (PMID = 19151136.001).
  • [ISSN] 1098-5530
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / DNA Transposable Elements; EC 3.1.- / Deoxyribonucleases
  • [Other-IDs] NLM/ PMC2655492
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88. Carini M, Quadrio M: Direct-numerical-simulation-based measurement of the mean impulse response of homogeneous isotropic turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2010 Dec;82(6 Pt 2):066301

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Such a measurement is carried out here on the basis of direct numerical simulation (DNS).
  • This technique to measure the turbulent response in a DNS numerical experiment is a research tool in that field of spectral closures where the linear-response concept is invoked either by resorting to renormalized perturbations theories or by introducing the well-known fluctuation-dissipation relation (FDR).
  • Both the characteristic form and the time scaling properties of the response function are investigated in the universal subrange of dissipative wave numbers; a comparison with the response approximation given by the FDR is proposed through the independent DNS measurement of the correlation function.

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  • (PMID = 21230728.001).
  • [ISSN] 1550-2376
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Guan L, Li ZY, Zhao JY, Xu XX, Wen T, Zhang YL: [Dynamic changes of hemorheology in rats after carbon monoxide poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2010 Dec;28(12):885-90
MedlinePlus Health Information. consumer health - Carbon Monoxide Poisoning.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To investigate the startup detail of circulation dysfunction and its role in the progress of delayed neuropsychologic sequelae (DNS) after carbon monoxide (CO) poisoning with comparison with the model of ischemia-reperfusion.
  • METHODS: The ischemia-reperfusion rat model was established by Pulsinelli-Brierley method, and the CO poisoning rats model by i.p. injected with CO repeatedly respectively, and the rats were identified with DNS following the experiment of pathology and the ethnology.
  • CONCLUSION: There are significantly sustained hyper-coagulation and hyper-viscosity with circulation in rats after CO poisoning compared with ischemia-reperfusion model during the period of DNS, which might contribute to increase cerebral circulation resistance, blocked blood flow, and deteriorate hypoxemia in progression of DNS.
  • [MeSH-minor] Animals. Disease Models, Animal. Hemorheology. Male. Rats. Rats, Sprague-Dawley. Reperfusion Injury / physiopathology

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  • (PMID = 21241595.001).
  • [ISSN] 1001-9391
  • [Journal-full-title] Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
  • [ISO-abbreviation] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
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90. van de Meent JW, Morozov A, Somfai E, Sultan E, van Saarloos W: Coherent structures in dissipative particle dynamics simulations of the transition to turbulence in compressible shear flows. Phys Rev E Stat Nonlin Soft Matter Phys; 2008 Jul;78(1 Pt 2):015701
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The structures we find are remarkably consistent with experimental observations and direct numerical simulations (DNS) simulations of incompressible flows, despite a difference in Mach number of several orders of magnitude.

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  • (PMID = 18764013.001).
  • [ISSN] 1539-3755
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Lo CP, Chen SY, Chou MC, Wang CY, Lee KW, Hsueh CJ, Chen CY, Huang KL, Huang GS: Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation. Eur J Neurol; 2007 Jul;14(7):777-82
MedlinePlus Health Information. consumer health - Carbon Monoxide Poisoning.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation.
  • The purpose of this study is to assess the efficacy of hyperbaric oxygen therapy (HBOT) in patients with delayed neuropsychiatric syndrome (DNS) caused by carbon monoxide (CO) inhalation using diffusion tensor magnetic resonance (MR) imaging and neuropsychological test.
  • Conventional and diffusion tensor brain MR imaging exams were performed in six patients with DNS immediately before and 3 months after the HBOT to obtain fractional anisotropy (FA) values.
  • Diffusion tensor MR imaging can be a quantitative method for the assessment of the white matter change and monitor the treatment response in patients of CO-induced DNS with a good clinical correlation.
  • HBO may be an effective therapy for DNS.
  • [MeSH-minor] Adult. Anisotropy. Depressive Disorder / complications. Depressive Disorder / psychology. Female. Follow-Up Studies. Humans. Lipid Peroxidation. Male. Middle Aged. Movement Disorders / etiology. Movement Disorders / pathology. Movement Disorders / therapy. Neuropsychological Tests. Suicide, Attempted. Time Factors

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  • (PMID = 17594334.001).
  • [ISSN] 1468-1331
  • [Journal-full-title] European journal of neurology
  • [ISO-abbreviation] Eur. J. Neurol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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92. Ong TT, Tang W, Muderawan W, Ng SC, Chan HS: Synthesis and application of single-isomer 6-mono(alkylimidazolium)-beta-cyclodextrins as chiral selectors in chiral capillary electrophoresis. Electrophoresis; 2005 Oct;26(20):3839-48

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  • The chiral resolution abilities of these cationic CDs were studied by CE using dansyl (Dns)-amino acids as model analytes.
  • The BGE pH played an important role in the resolution of Dns-amino acids.
  • Methanol was found to be an effective organic modifier for the resolution of Dns-amino acids by CE.

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  • (PMID = 16167309.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Buffers; 0 / Dansyl Compounds; 0 / beta-Cyclodextrins
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93. Tonan T, Fujimoto K, Azuma S, Ono N, Matsushita S, Kojiro M, Hayabuchi N: Evaluation of small (&lt;or=2 cm) dysplastic nodules and well-differentiated hepatocellular carcinomas with ferucarbotran-enhanced MRI in a 1.0-T MRI unit: utility of T2*-weighted gradient echo sequences with an intermediate-echo time. Eur J Radiol; 2007 Oct;64(1):133-9
Hazardous Substances Data Bank. IRON, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of small (<or=2 cm) dysplastic nodules and well-differentiated hepatocellular carcinomas with ferucarbotran-enhanced MRI in a 1.0-T MRI unit: utility of T2*-weighted gradient echo sequences with an intermediate-echo time.
  • PURPOSE: To evaluate the detectability and signal intensities of small (<or=2 cm) dysplastic nodules (DNs) and well-differentiated hepatocellular carcinomas (w-HCCs) by T2*-weighted gradient echo (GRE) sequences using an intermediate echo-time (TE) with ferucarbotran in a 1.0-T magnetic resonance imaging (MRI) unit.
  • MATERIALS AND METHODS: Pathologically confirmed DNs (n=13) and w-HCCs (n=31) with a median largest dimension of 1.1cm were scanned using ferucarbotran-enhanced MRI.
  • Qualitative and quantitative analyses indicated that specific-T2*GRE sequences were superior to conventional-T2*-GRE sequences for detecting DNs and w-HCCs with hypointense signals.
  • The tumor-liver-CNR of DNs was significantly different between specific-T2*-GRE sequences and conventional-T2*-GRE sequences (Mann-Whitney test, P<0.001).
  • CONCLUSION: Specific-T2*-GRE sequences with ferucarbotran are useful for detecting DNs and w-HCCs that produce hypointense signals on a 1.0-T MRI unit.

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  • (PMID = 17408900.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; E1UOL152H7 / Iron; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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94. Agrawal L, Louboutin JP, Marusich E, Reyes BA, Van Bockstaele EJ, Strayer DS: Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates. Brain Res; 2010 Jan 8;1306:116-30
SciCrunch. The Antibody Registry: Reagent: Antibodies .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We examined the role of reactive oxygen species (ROS) in loss of dopaminergic neurons (DNs) from the substantia nigra (SN) in neuroAIDS.
  • However, unlike apoptosis caused by H(2)O(2), gp120-induced DN apoptosis was specific: DNs were specifically more sensitive than RN to receptor-mediated [Ca(2+)](i) fluxes triggered by gp120.
  • DNs are therefore specifically hypersensitive to gp120-induced apoptosis, signaling for which involves ROS intermediates.

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  • HIV InSite. treatment guidelines - Women and HIV .
  • Hazardous Substances Data Bank. DOPAMINE .
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • Hazardous Substances Data Bank. HYDROGEN PEROXIDE .
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  • (PMID = 19815008.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / MH70287
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / HIV Envelope Protein gp120; 0 / Reactive Oxygen Species; 0 / gp120 protein, Human immunodeficiency virus 1; BBX060AN9V / Hydrogen Peroxide; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.- / superoxide dismutase 1; EC 1.15.1.1 / Superoxide Dismutase; SY7Q814VUP / Calcium; VTD58H1Z2X / Dopamine
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95. Park YN, Kojiro M, Di Tommaso L, Dhillon AP, Kondo F, Nakano M, Sakamoto M, Theise ND, Roncalli M: Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer; 2007 Mar 1;109(5):915-23
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules.
  • BACKGROUND: Stromal invasion is 1 of the main features used to distinguish high-grade dysplastic nodules (DNs) from well-differentiated hepatocellular carcinomas (HCCs).
  • The nodules were classified histologically prior to immunostaining as noninvasive (large regenerative nodules, low-grade DNs, and high-grade DNs), minimally invasive (early HCCs with a vaguely nodular type), and overtly invasive (typical HCCs with a distinctly nodular type) in a review by expert pathologists, the current gold standard.
  • CONCLUSIONS: DR/CK7 immunostaining may help to identify small foci of invasion and to distinguish noninvasive, high-grade DNs from both minimally invasive and overtly invasive HCCs.

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  • (PMID = 17279586.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Keratin-7
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96. An JY, Park MS, Kim JS, Shon YM, Lee SJ, Kim YI, Lee KS, Kim BJ: Comparison of diabetic neuropathy symptom score and medial plantar sensory nerve conduction studies in diabetic patients showing normal routine nerve conduction studies. Intern Med; 2008;47(15):1395-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Diabetic Neuropathy Symptom (DNS) scoring and medial plantar NCS are useful methods for diagnosis of diabetic polyneuropathy (DPN).
  • We evaluated the correlation between DNS score and medial plantar NCS in diabetic patients with a normal routine NCS.
  • The amplitudes of sural (Spearman r=-0.293, p=0.003) and medial plantar NAP (Spearman r=-0.215, p=0.03) correlated with DNS score.
  • CONCLUSION: An abnormality finding in the medial plantar sensory nerve conduction study is a more sensitive indicator than sural nerve conduction study in the diagnosis of DPN and the medial plantar sensory nerve should be included in the evaluation of DPN in patients showing normal routine NCS.

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  • (PMID = 18670144.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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97. Sullivan KA, McLaughlin D, Hasson F: Exploring district nurses' experience of a hospice at home service. Br J Community Nurs; 2005 Nov;10(11):496-502
MedlinePlus Health Information. consumer health - Home Care Services.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This study surveyed a representative sample of district nurses (DNs) to ascertain their experience of working alongside an HAH service.
  • A self-completed postal questionnaire comprised of 14 items was distributed to 128 DNs.
  • However, the need for improved communication and increased awareness among DNs about the HAH service were also identified.
  • The findings support the idea that an HAH service can enable patients with advanced progressive disease to be cared for at home.

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  • (PMID = 16301923.001).
  • [ISSN] 1462-4753
  • [Journal-full-title] British journal of community nursing
  • [ISO-abbreviation] Br J Community Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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98. Vafopoulou X, Terry KL, Steel CG: The circadian timing system in the brain of the fifth larval instar of Rhodnius prolixus (hemiptera). J Comp Neurol; 2010 Apr 15;518(8):1264-82
SciCrunch. The Antibody Registry: Reagent: Antibodies .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A second group of clock cells (dorsal neurons [DNs]), situated in the posterior dorsal protocerebrum, are devoid of PDF.
  • The DNs receive two fine axons from the LNs, indicating that clock cells throughout the brain are integrated into a timing network.

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 20151359.001).
  • [ISSN] 1096-9861
  • [Journal-full-title] The Journal of comparative neurology
  • [ISO-abbreviation] J. Comp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insect Proteins
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99. Liao W, Peng Y, Luo LS: Gas-kinetic schemes for direct numerical simulations of compressible homogeneous turbulence. Phys Rev E Stat Nonlin Soft Matter Phys; 2009 Oct;80(4 Pt 2):046702
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We intend to study the accuracy, stability, and efficiency of the gas-kinetic scheme for DNS of compressible homogeneous turbulence depending on both flow conditions and numerics.
  • Our results show that the GKS is adequate for DNS of compressible homogeneous turbulence as far as the low-order turbulence statistics are concerned.

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  • (PMID = 19905477.001).
  • [ISSN] 1550-2376
  • [Journal-full-title] Physical review. E, Statistical, nonlinear, and soft matter physics
  • [ISO-abbreviation] Phys Rev E Stat Nonlin Soft Matter Phys
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gases
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100. Pletneva EV, Gray HB, Winkler JR: Nature of the cytochrome c molten globule. J Am Chem Soc; 2005 Nov 9;127(44):15370-1
Saccharomyces Genome Database. Saccharomyces Genome Database .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We have employed fluorescence energy transfer (FET) kinetics to probe unfolded and molten globule states of five dansyl (Dns) variants of Saccharomyces cerevisiae iso-1 cytochrome c.
  • The covalently bound Fe(III) heme group quenches Dns fluorescence by energy transfer; measurements of FET kinetics yielded distributions of D-A distances (P(r)) for these states.

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  • (PMID = 16262391.001).
  • [ISSN] 0002-7863
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM 068461
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-43-6 / Cytochromes c
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