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1. Böttger C, Warth A, Nawroth PP, Isermann B: [Neuroendocrine carcinoma of the lung: a diagnostic and therapeutic challenge]. Med Klin (Munich); 2010 Apr;105(4):237-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neuroendocrine carcinoma of the lung: a diagnostic and therapeutic challenge].
  • The diagnosis was corrected, and an atypical neuroendocrine bronchial carcinoma was diagnosed.
  • Based on this case, the diagnostic criteria, prognostic factors and therapeutic options of neuroendocrine bronchial carcinomas are discussed.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Carcinoma, Bronchogenic / diagnosis. Carcinoma, Bronchogenic / pathology. Carcinoma, Bronchogenic / secondary. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / pathology. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / secondary. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adrenal Glands / pathology. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / metabolism. Bone Neoplasms / diagnosis. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Calcitonin / metabolism. Cell Division / physiology. Female. Humans. Ki-67 Antigen / metabolism. Liver / pathology. Lung / pathology. Middle Aged. Neoplasm Staging. Octreotide / administration & dosage. Paraneoplastic Syndromes / diagnosis. Paraneoplastic Syndromes / drug therapy. Paraneoplastic Syndromes / pathology. Sirolimus / administration & dosage. Thyroid Gland / pathology


2. Putti TC, El-Rehim DM, Rakha EA, Paish CE, Lee AH, Pinder SE, Ellis IO: Estrogen receptor-negative breast carcinomas: a review of morphology and immunophenotypical analysis. Mod Pathol; 2005 Jan;18(1):26-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to assess the morphological characteristics and immunohistochemical profile of ER-negative tumors and thus to understand the biological behavior and unique nature.
  • The majority of tumors were grade 3 (94%) and the commonest histological types were ductal/no specific type (85%), and atypical medullary carcinoma (8%).
  • High-grade comedo-type necrosis, lymphoid stroma, central necrosis/fibrosis and pushing margins were the most common morphological features.
  • Grade 3 histology, pushing margin, lymphoid stroma, comedo-type necrosis and central fibrosis/necrosis are the dominant morphological findings.
  • These unique features support the concept that ER-negative tumors are a morphologically and phenotypically distinct entity and provide a rationale for the study and use of newer promising agents in the treatment of ER-negative breast cancer.
  • [MeSH-minor] Actins / analysis. Adult. Aged. BRCA1 Protein / analysis. Cadherins / analysis. Carrier Proteins / analysis. Female. Glycoproteins / analysis. Humans. Immunohistochemistry. Keratins / analysis. Lymph Nodes / pathology. Lymphatic Metastasis. Middle Aged. Multivariate Analysis. Muscle, Smooth / chemistry. Oncogene Proteins v-erbB / analysis. Prognosis. Receptor, ErbB-2 / analysis. Survival Analysis. Tissue Array Analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15332092.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / BRCA1 Protein; 0 / Cadherins; 0 / Carrier Proteins; 0 / Glycoproteins; 0 / Oncogene Proteins v-erbB; 0 / PIP protein, human; 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins; EC 2.7.10.1 / Receptor, ErbB-2
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3. Hung WW, Wang CS, Tsai KB, Ou-Yang F, Shin SJ, Hsiao PJ: Medullary thyroid carcinoma with poor differentiation and atypical radiographic pattern of metastasis. Pathol Int; 2009 Sep;59(9):660-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medullary thyroid carcinoma with poor differentiation and atypical radiographic pattern of metastasis.
  • A diagnosis of sporadic medullary thyroid carcinoma (MTC) is complicated.
  • Herein is reported the case of a 73-year-old man who presented with two ill-defined pulmonary opacities, clinically resembling primary lung carcinoma.
  • [MeSH-major] Carcinoma, Medullary / secondary. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / therapeutic use. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Calcitonin / blood. Chromogranin A / analysis. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Diagnosis, Differential. Humans. Lung Neoplasms / chemistry. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Radiography, Thoracic. Synaptophysin / analysis. Thyroidectomy

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  • (PMID = 19712135.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Synaptophysin; 0W860991D6 / Deoxycytidine; 9007-12-9 / Calcitonin; B76N6SBZ8R / gemcitabine
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