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Items 1 to 73 of about 73
1. Nocito MJ, Lustia MM, Luna PC, Cañadas NG, Castellanos Posse ML, Marchesi C, Carabajal G, Mazzini MA: Atypical leiomyoma: An unusual variant of cutaneous pilar leiomyoma. Dermatol Online J; 2009;15(3):6
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  • [Title] Atypical leiomyoma: An unusual variant of cutaneous pilar leiomyoma.
  • Cutaneous atypical leiomyoma is an unusual benign tumor arising from arrector pili muscle that shares histological features with uterine atypical or symplastic leiomyoma: atypical cellularity with pleomorphic nuclei but minimal or no mitosis.
  • [MeSH-major] Leiomyoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19379650.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Neoplasm Proteins
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2. Jiang GH, Zhang LY, Li GY, Lin CL, Zeng SQ, Zhong BL, Tian JZ: [Atypical magnetic resonance imaging vs pathological findings of leiomyoma in the female reproductive system]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Feb;29(2):301-4
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  • [Title] [Atypical magnetic resonance imaging vs pathological findings of leiomyoma in the female reproductive system].
  • OBJECTIVE: To investigate magnetic resonance imaging (MRI) findings of the atypical leiomyoma in the female reproductive system in comparison with the pathological features of the neoplasms.
  • METHODS: A retrospective analysis of the MRI findings and the pathological features was conducted in 24 cases of atypical leiomyoma involving the female reproductive system.
  • RESULTS: Atypical leiomyomas were displayed by MRI as solid tumor mass surrounded by cystic degeneration, pseudotumors, or solid mass with homogeneous signal intensity.
  • CONCLUSION: Leiomyoma can occur at almost any site in the female reproductive system, and atypical leiomyoma usually are shown as solid cystic mixed mass in the pelvic cavity.
  • Evaluation of the relationship between the solid mass and cystic portion and observation for the presence of low signal on T2WI may help in the diagnosis of atypical leiomyoma.
  • [MeSH-major] Genital Neoplasms, Female / pathology. Leiomyoma / pathology. Magnetic Resonance Imaging. Uterine Neoplasms / pathology

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  • (PMID = 19246306.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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3. Rammeh-Rommani S, Mokni M, Stita W, Trabelsi A, Hamissa S, Sriha B, Tahar-Yacoubi M, Korbi S: [Uterine smooth muscle tumors: retrospective epidemiological and pathological study of 2760 cases]. J Gynecol Obstet Biol Reprod (Paris); 2005 Oct;34(6):568-71
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  • Some leiomyomas may have unusual morphologic features difficult to distinguish from leiomyosarcoma.
  • These tumors are: cellular leiomyoma, atypical leiomyoma and mitotically active leiomyoma.
  • OBJECTIVES: The purpose of our work is to study cases of leiomyosarcomas, cellular leiomyoma, atypical leiomyoma and mitotically active leiomyoma among a large series of uterine smooth muscle tumors.
  • RESULTS: Review of the slides demonstrated: 12 mitotically active leiomyomas, 18 cellular leiomyomas, 20 atypical leiomyomas, 16 leiomysarcomas, only one case of smooth muscle tumor of uncertain malignant potential.
  • The 2709 remaining tumors were all common leiomyomas.
  • So mitotically active, cellular and atypical leiomyomas were as rare as the leiomyosarcomas.
  • The average age of patients with leiomyomas was 39 years.
  • Average size of leiomyomas was 7.4cm.
  • The average age and size of the 3 studied variants of leiomyomas were identical to those of the common leiomyomas.
  • Leiomyomas were unique in 60.9% of cases.
  • [MeSH-minor] Female. Humans. Leiomyoma / epidemiology. Leiomyoma / pathology. Neoplasm Recurrence, Local. Retrospective Studies

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  • (PMID = 16208199.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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4. Ip PP, Cheung AN, Clement PB: Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol; 2009 Jul;33(7):992-1005
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  • RESULTS: The tumors were classified as follows: 6 as "atypical leiomyoma with limited experience", 7 as "smooth muscle tumor of low malignant potential", 2 as "atypical leiomyoma, low risk of recurrence," and 1 as "mitotically active leiomyoma, limited experience."
  • Only 2 tumors recurred, at 15 and 51 months, respectively; both were atypical leiomyoma with limited experience (multifocal moderate-to-severe atypia, no tumor cell necrosis, and mitotic counts of 4 and 5 mitotic figures /10 high-power fields, respectively).
  • Both tumors had areas that were indistinguishable from benign leiomyoma and both had diffuse immunoreactivity for p16 and p53.
  • Both of the latter tumors fulfilled the criteria for atypical leiomyoma with limited experience.

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  • (PMID = 19417585.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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5. Mittal KR, Chen F, Wei JJ, Rijhvani K, Kurvathi R, Streck D, Dermody J, Toruner GA: Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. Mod Pathol; 2009 Oct;22(10):1303-11
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  • [Title] Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas.
  • It is uncertain whether uterine leiomyosarcoma arises de novo or in preexisting leiomyoma.
  • Leiomyoma-like areas can be seen associated with uterine leiomyosarcoma, raising the possibility of precursor lesions for uterine leiomyosarcoma.
  • In this study, we examined cases of uterine leiomyosarcoma associated with leiomyoma-like areas at the histological, immunohistochemical and DNA level to further evaluate if benign-looking leiomyoma-like and uterine leiomyosarcoma areas are related.
  • Cases of uterine leiomyosarcoma observed at the New York University Medical Center from 1994 to 2007 were reviewed for the presence of leiomyoma-like areas.
  • Of the 26 cases of uterine leiomyosarcoma observed during this period, 18 cases had an associated leiomyoma-like area (five cellular leiomyoma, four symplastic leiomyoma, four cellular and symplastic leiomyoma and five usual type leiomyoma).
  • Immunohistochemical profiles were as expected for leiomyoma-like (the mean expression of p53, ER, PR and Ki-67 at 0.3, 63, 75 and 0.6%, respectively), symplastic leiomyoma-like areas (the mean expression of p53, ER, PR and Ki-67 at 0.6, 85, 89 and 5.5%, respectively) and uterine leiomyosarcoma areas (the mean expression of p53, ER, PR and Ki-67 at 52, 38, 39 and 61%, respectively).
  • In six cases, the leiomyoma-like and uterine leiomyosarcoma areas from each case were examined using high-density oligonucleotide array-CGH to determine genetic aberrations in the two areas.
  • Nearly all the genetic aberrations found in leiomyoma-like areas were also found in the corresponding uterine leiomyosarcoma areas.
  • The immunohistochemical profiles and genetic aberrations of the examined cases suggest that uterine leiomyosarcoma could arise from the preexisting leiomyoma-like areas that often have a symplastic or cellular morphology.
  • [MeSH-major] Biomarkers, Tumor / analysis. Gene Expression Profiling. Immunohistochemistry. Leiomyoma / diagnosis. Leiomyosarcoma / diagnosis. Precancerous Conditions / diagnosis. Uterine Neoplasms / diagnosis

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  • (PMID = 19633649.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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6. Sung CO, Ahn G, Song SY, Choi YL, Bae DS: Atypical leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A, p53, Ki-67, estrogen receptors, and progesterone receptors. Int J Gynecol Pathol; 2009 Nov;28(6):529-34
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  • [Title] Atypical leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A, p53, Ki-67, estrogen receptors, and progesterone receptors.
  • Atypical leiomyomas are characterized by moderately to severely pleomorphic atypical tumor cells with low mitotic counts and no coagulative tumor cell necrosis.
  • The behavior of atypical leiomyomas treated with myomectomy alone is still not known.
  • We present a study of 13 atypical leiomyomas treated with myomectomy alone with long-term follow-up results and immunohistochemical findings for p16 (p16), p53, Ki-67, estrogen receptors, and progesterone receptors.
  • None of the patients had developed a metastasis of her atypical leiomyoma.
  • Immunostaining for p16 showed moderate to strong diffuse immunoreactivity in 11/13 cases (84.6%) of atypical leiomyomas, and 38.5% showed immunoreactivity for p53, including 1 case with strong, diffuse positive p53.
  • When an atypical leiomyoma is discovered in a myomectomy specimen, the patient should be carefully followed up with or hysterectomy could be recommended.
  • Larger numbers of cases and more long-term follow-up studies are needed to confirm the safety of myomectomy for atypical leiomyomas.
  • [MeSH-major] Biomarkers, Tumor / analysis. Leiomyoma / metabolism. Leiomyoma / surgery. Uterine Neoplasms / metabolism. Uterine Neoplasms / surgery

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  • (PMID = 19851199.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / Tumor Suppressor Protein p53
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7. Murakami M, Uehara H, Nishimura M, Iwasa T, Ikawa H: A huge ovarian smooth muscle tumor: a case report. J Med Invest; 2010 Feb;57(1-2):158-62
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  • According to the criteria for the evaluation of the uterine smooth muscle tumors, this huge tumor was diagnosed as atypical leiomyoma.

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  • (PMID = 20299756.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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8. McCluggage WG, Boyde A: Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant. Int J Surg Pathol; 2007 Jul;15(3):262-5
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  • [Title] Uterine angioleiomyomas: a report of 3 cases of a distinctive benign leiomyoma variant.
  • We report 3 cases of a distinctive uterine leiomyoma containing numerous thick-walled vascular channels, which we term angioleiomyoma.
  • The leiomyomas occurred in women aged 33, 44, and 49 and ranged from 1.5 to 6.0 cm.
  • We believe angioleiomyoma should be recognized as a distinct entity and included in the World Health Organization classification of tumors of the female genital tract as a benign leiomyoma variant, similar to cellular and atypical leiomyoma.
  • [MeSH-major] Angiomyoma / pathology. Leiomyoma / pathology. Uterine Neoplasms / pathology

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  • (PMID = 17652533.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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9. Ip PP, Tse KY, Tam KF: Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol; 2010 Mar;17(2):91-112
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  • [Title] Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy.
  • Uterine smooth muscle tumors are classified according to their morphologic features that include architecture, growth pattern, cellular characteristics and constituents of the intercellular stroma.
  • While terminologies used for the pathologic diagnosis of various subtypes may be eloquent and histologically accurate, some of these are confusing for the clinician and may also be open to interpretation by different pathologists: the labeling of atypical leiomyomas epitomizes this intricate system.
  • The term "atypical leiomyoma" has been used to label tumors that have a low risk of recurrence and is synonymous with benign tumors.
  • The latter are known variously as leiomyoma with bizarre nuclei, symplastic leiomyoma, or pleomorphic leiomyoma.
  • Variants of benign uterine smooth muscle tumors, such as mitotically active leiomyoma, cellular and highly cellular leiomyoma, epithelioid leiomyoma, and myxoid leiomyoma each have distinctive hallmarks that enable subclassification.
  • The current review discusses the pathologic diagnosis of and terminology applied to selected variants of uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas with emphasis on unusual reported features that may indicate malignancy.
  • This includes an update on uterine smooth muscle tumor of uncertain malignant potential (STUMP), intravenous leiomyomatosis, benign metastasizing leiomyoma, and diffuse leiomyomatosis.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Leiomyoma / pathology. Leiomyoma, Epithelioid / pathology. Leiomyomatosis / pathology. Lung Neoplasms / secondary. Middle Aged. Neoplasm Recurrence, Local / pathology

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  • (PMID = 20179432.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 156
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10. Erdogan G, Bassorgun CI, Pestereli HE, Simsek T, Karaveli S: C-kit protein expression in uterine and ovarian mesenchymal tumours. APMIS; 2007 Mar;115(3):204-9
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  • The morphologic similarity of uterine mesenchymal tumours and GIST, and the presence of KIT protein in normal uterine tissue, suggests that uterine sarcomas may have the same c-kit overexpression.
  • Immunohistochemical staining using a polyclonal anti-c-kit antibody was performed on tissue blocks from 12 carsinosarcomas, 14 leiomyosarcomas, 8 endometrial stromal sarcomas, 2 adenosarcomas, 1 atypical leiomyoma, 1 leiomyoma with limited experience, and 10 leiomyomas.
  • C-kit was positive in 10 of 12 (83%) carcinosarcomas, 10 of 14 (71%) leiomyosarcomas, 6 of 8 75(%) endometrial stromal sarcomas, 1 of 2 (50%) adenosarcomas, 1 leiomyoma with limited experience, and 1 of 10 (10%) leiomyomas.

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  • (PMID = 17367465.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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11. Kepenekci I, Demirkan A, Sözener U, Cakmak A, Demirer S, Alaçayir I, Ekinci C: Suprarenal symplastic leiomyoma of the inferior vena cava. Ann Vasc Surg; 2009 Nov-Dec;23(6):786.e11-3

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  • [Title] Suprarenal symplastic leiomyoma of the inferior vena cava.
  • We report on a case of a leiomyoma in the inferior vena cava that appeared in the image to be located in the adrenal gland.
  • Histopathological work-up of the tumor revealed smooth muscle fibers and marked nuclear pleomorphism consistent with symplastic leiomyoma.
  • [MeSH-major] Leiomyoma. Vascular Neoplasms. Vena Cava, Inferior

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  • (PMID = 19733033.001).
  • [ISSN] 1615-5947
  • [Journal-full-title] Annals of vascular surgery
  • [ISO-abbreviation] Ann Vasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Kashyap S, Kaur S, Kaur D: A rare spectrum of lesions encountered in fibroid uterus: histopathological report. Indian J Pathol Microbiol; 2007 Oct;50(4):790-1

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  • Symplasmic or atypical leiomyoma and lipoleiomyoma are two very rare morphological variants of leiomyoma of the uterus.
  • Both the tumours show a benign behavior like the classical leiomyoma.
  • But differentiated from the classical leiomyoma by presence of bizarre cellular pattern with paucity of mitosis and presence of mature lipocytes within a leiomyoma respectively.
  • [MeSH-major] Leiomyoma / diagnosis. Leiomyoma / pathology

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  • (PMID = 18306556.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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13. Yasmeen F, Hafeez M, Hameed S, Saeed A, Ibnerasa SN: Symplastic leiomyoma of uterus: a rare histological variant. J Coll Physicians Surg Pak; 2008 May;18(5):308-9
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  • [Title] Symplastic leiomyoma of uterus: a rare histological variant.
  • Symplastic leiomyoma is a rare histological variant of leiomyoma.
  • Histopathology of that myomectomy showed symplastic leiomyoma with absent mitotic figures.
  • [MeSH-major] Leiomyoma / pathology. Uterine Neoplasms / pathology

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  • (PMID = 18541089.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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14. Usubütün A, Karaman N, Ayhan A, Küçükali T: Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report. Int J Gynecol Pathol; 2005 Oct;24(4):352-4

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  • [Title] Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
  • We presented a polypoid leiomyoma with bizarre nuclei having atypical endometrial stromal cells adjacent to the leiomyoma.
  • Although atypical stromal cells of the female genital tract have been described, to our knowledge, no lesion identical to ours has been reported thus far.
  • These atypical cells may be mistaken for malignant cells on histologic examination, especially in small endometrial samples.
  • To differentiate these kinds of atypical-featured lesions from sarcoma is important, especially in curettage materials.
  • The etiology and precise nature of multinucleated giant cells and atypical stromal cells in the endometrium are unclear.
  • To prevent radical surgery, pathologists must be familiar with these atypical cells in the female genital tract.
  • [MeSH-major] Cell Nucleus / pathology. Endometrial Neoplasms / pathology. Endometrium / pathology. Leiomyoma / pathology. Polyps / pathology. Stromal Cells / pathology

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  • (PMID = 16175081.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Hossain D, Meiers I, Qian J, MacLennan GT, Bostwick DG: Prostatic leiomyoma with atypia: follow-up study of 10 cases. Ann Diagn Pathol; 2008 Oct;12(5):328-32
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  • [Title] Prostatic leiomyoma with atypia: follow-up study of 10 cases.
  • We studied the clinical and histologic features of 10 cases of prostatic leiomyoma with atypical bizarre nuclei.
  • The histologic findings consisted of a solid circumscribed expansile stromal nodule with abundant smooth muscle and variable numbers of atypical bizarre giant cells.
  • [MeSH-major] Leiomyoma / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 18774494.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Receptors, Androgen; 0 / Vimentin
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16. Usmani N, Merchant W, Yung A: A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma. J Cutan Pathol; 2008 Mar;35(3):329-31
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  • [Title] A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma.
  • We describe the case of a cutaneous symplastic leiomyoma in a 37-year-old woman who presented with a 4-year history of a painful slow growing lesion on the left upper arm.
  • The diagnosis was felt to be in keeping with a cutaneous symplastic leiomyoma, a rarely reported variant of the pilar leiomyoma.
  • Histologically, it shows features similar to the symplastic variant of uterine leiomyoma with cytological atypia, nuclear pleomorphism and minimal mitotic activity.
  • [MeSH-major] Leiomyoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 18251750.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin
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17. Granata G, Martinoli C, Pazzaglia C, Caliandro P, Padua L, Ferraro D: Letter to Editor: Carpal tunnel syndrome due to an atypical deep soft tissue leiomyoma: the risk of misdiagnosis and mismanagement. World J Surg Oncol; 2008;6:22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Letter to Editor: Carpal tunnel syndrome due to an atypical deep soft tissue leiomyoma: the risk of misdiagnosis and mismanagement.
  • A response to Chalidis et al: Carpal tunnel syndrome due to an atypical deep soft tissue leiomyoma: The risk of misdiagnosis and mismanagement.
  • [MeSH-major] Carpal Tunnel Syndrome / etiology. Diagnostic Errors. Leiomyoma / complications. Leiomyoma / diagnosis. Soft Tissue Neoplasms / complications. Soft Tissue Neoplasms / diagnosis

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  • [Cites] Neurol Sci. 2006 Feb;26(6):430-4 [16601936.001]
  • [Cites] Clin Neurophysiol. 2007 Jun;118(6):1410-6 [17466584.001]
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  • [CommentOn] World J Surg Oncol. 2007;5:92 [17686170.001]
  • (PMID = 18284709.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2278133
  •  go-up   go-down


18. Chalidis BE, Dimitriou CG: Carpal tunnel syndrome due to an atypical deep soft tissue leiomyoma: The risk of misdiagnosis and mismanagement. World J Surg Oncol; 2007;5:92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carpal tunnel syndrome due to an atypical deep soft tissue leiomyoma: The risk of misdiagnosis and mismanagement.
  • BACKGROUND: Leiomyomas of the deep soft tissue are quite uncommon and occur even more rarely in upper extremity.
  • Histopathological findings of the resected mass were consistent with leiomyoma.
  • CONCLUSION: Despite the fact that reports on deep soft tissue leiomyoma are exceptional, this tumor had to be considered as differential diagnosis in painful non-traumatic hand syndromes especially in young patients.

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  • [Cites] Am J Surg Pathol. 1998 Jul;22(7):897-901 [9669352.001]
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  • [CommentIn] World J Surg Oncol. 2008;6:22 [18284709.001]
  • (PMID = 17686170.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1971266
  •  go-up   go-down


19. Hosseini H, Jacquemyn Y, Goossens K, Van Marck V: Atypical uterine leiomyoma: a rare variant of a common problem. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical uterine leiomyoma: a rare variant of a common problem.
  • A myomectomy was performed in a 35-year-old woman, and microscopic examination of the resulting specimen revealed an atypical myoma.

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  • [Cites] J Reprod Med. 2007 Nov;52(11):1001-10 [18161397.001]
  • [Cites] Cancer. 1988 Nov 15;62(10):2239-47 [3179938.001]
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  • (PMID = 21686982.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027545
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20. Cramer SF, Newcomb PM, Bonfiglio TA: Myometrial dysplasia (atypical myometrial hyperplasia). Hum Pathol; 2007 Apr;38(4):652-5
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  • [Title] Myometrial dysplasia (atypical myometrial hyperplasia).
  • Although precursor lesions are well known for cervical and endometrial neoplasms, precursor lesions are not currently recognized for the most common tumor of the uterus-leiomyomas.
  • Myometrial hyperplasia has been recently described and evaluated by morphometry, but its relationship to uterine leiomyomas has not been systematically explored.
  • Myometrial dysplasia (atypical myometrial hyperplasia) has not been previously recognized.
  • The paradoxical rarity of myometrial dysplasia is considered in comparison to the striking frequency of uterine leiomyomas.
  • [MeSH-minor] Adult. Female. Humans. Hyperplasia / complications. Hyperplasia / pathology. Leiomyoma / etiology. Leiomyoma / pathology. Tumor Suppressor Protein p53 / analysis

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  • [CommentIn] Hum Pathol. 2007 Aug;38(8):1289 [17640556.001]
  • (PMID = 17367607.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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21. Yarci A, Bayramov V, Sükür YE, Yüce T, Berker B: Vaginal vault leiomyoma: 25 years after total abdominal hysterectomy. J Minim Invasive Gynecol; 2010 Jan-Feb;17(1):116-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vaginal vault leiomyoma: 25 years after total abdominal hysterectomy.
  • Leiomyomas are benign, mesenchymal, monoclonal tumors that typically originate from myometrium smooth-muscle cells, although atypical sites such as the vagina, lungs, vascular structures, and retroperitoneal area have been reported.
  • We present the case of a leiomyoma that originated from the vaginal cuff in a 70-year-old woman, 25 years after total abdominal hysterectomy and bilateral salphingo-oophorectomy.
  • [MeSH-major] Leiomyoma / surgery. Vaginal Neoplasms / surgery

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  • [Copyright] Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20129345.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Metzdorf MM, Schmidt JD: Urinary bladder leiomyoma associated with pulmonary lymphangioleiomyomatosis. Urology; 2008 Apr;71(4):755.e3-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urinary bladder leiomyoma associated with pulmonary lymphangioleiomyomatosis.
  • Leiomyomas account for less than 0.43% of all bladder tumors.
  • Pulmonary lymphangioleiomyomatosis (LAM) is a rare lung disease featuring abnormal proliferation of atypical smooth muscle cells around bronchovascular structures.
  • We describe a woman with LAM who presented with pelvic pain and was found to have a leiomyoma of the bladder wall.
  • [MeSH-major] Leiomyoma / diagnosis. Lung Neoplasms / pathology. Lymphangioleiomyomatosis / pathology. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 18313110.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Fernandez-Flores A: Cutaneous leiomyomas and leiomyosarcomas: an immunohistochemical study with p53. Rom J Morphol Embryol; 2010;51(2):295-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous leiomyomas and leiomyosarcomas: an immunohistochemical study with p53.
  • BACKGROUND: Cutaneous smooth muscle tumors are rare and sometimes the differential diagnosis between leiomyoma and leiomyo-sarcoma is difficult and based in very subtle criteria.
  • This marker has rarely been reported in cutaneous leiomyomas and even in more rare occasions, in cutaneous leiomyomas.
  • MATERIAL AND METHODS: We studied 30 benign cutaneous smooth muscle tumors, including angioleiomyomas, common leiomyomas and a symplastic leiomyoma, as well as four leiomyosarcomas and one cutaneous metastasis of leiomyosarcoma.
  • No expression of p53 was found in the only case of symplastic leiomyoma, which was investigated.
  • [MeSH-major] Leiomyoma / metabolism. Leiomyosarcoma / metabolism. Skin Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20495746.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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24. Giuntoli RL 2nd, Gostout BS, DiMarco CS, Metzinger DS, Keeney GL: Diagnostic criteria for uterine smooth muscle tumors: leiomyoma variants associated with malignant behavior. J Reprod Med; 2007 Nov;52(11):1001-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic criteria for uterine smooth muscle tumors: leiomyoma variants associated with malignant behavior.
  • The 20 other patients were deemed to have leiomyomas or leiomyoma variants, including 13 cellular leiomyomas, 5 atypical leiomyomas and 2 leiomyomas.
  • ) With leiomyoma variants, median survival was > 25 years.
  • A small but significant number of patients diagnosed with leiomyoma variants will die of the disease.
  • In contrast to the aggressive behavior of uterine LMS, disease-specific deaths attributed to leiomyoma variants occurred later.
  • [MeSH-major] Leiomyoma / diagnosis. Smooth Muscle Tumor / diagnosis. Uterine Neoplasms / diagnosis


25. Rudisaile SN, Hurt MA, Santa Cruz DJ: Granular cell atypical fibroxanthoma. J Cutan Pathol; 2005 Apr;32(4):314-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell atypical fibroxanthoma.
  • We report on two patients with granular cell atypical fibroxanthoma.
  • Microscopically, these neoplasms showed a dermal proliferation of pleomorphic granular cells with irregular hyperchromatic nuclei, multinucleated cells, and scattered mitoses.
  • Immunohistochemical stains were positive for CD68 and vimentin and negative for Melan-A or human melanoma black (HMB)-45, S-100 protein, pancytokeratin, and actin, consistent with atypical fibroxanthoma.
  • These include the conventional granular cell tumor and its malignant form, leiomyoma, leiomyosarcoma, dermatofibroma, dermatofibrosarcoma protuberans, and angiosarcoma.

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  • (PMID = 15769283.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 25
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26. Dundr P, Povýsil C, Tvrdík D, Mára M: Uterine leiomyomas with inclusion bodies: an immunohistochemical and ultrastructural analysis of 12 cases. Pathol Res Pract; 2007;203(3):145-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uterine leiomyomas with inclusion bodies: an immunohistochemical and ultrastructural analysis of 12 cases.
  • We describe 12 cases of leiomyoma with intracytoplasmic inclusion bodies, which were detected in a group of 447 leiomyomas examined at our institution between December 2005 and March 2006.
  • Ten of these tumors were typical leiomyomas, and two cases represented atypical (bizarre) leiomyoma.
  • The intracytoplasmic inclusions were found in atypical (bizarre) leiomyomas of the uterus and occasionally in epithelioid leiomyomas and leiomyosarcomas.
  • However, to the best of our knowledge, these inclusions have not been found in typical uterine leiomyomas to date.
  • [MeSH-major] Inclusion Bodies / chemistry. Inclusion Bodies / ultrastructure. Leiomyoma / chemistry. Leiomyoma / ultrastructure. Uterine Neoplasms / chemistry. Uterine Neoplasms / ultrastructure

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  • (PMID = 17306931.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 0 / Azo Compounds; 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / Myogenin; 0 / Vimentin; 0 / trichrome stain; 68238-35-7 / Keratins; 82-94-0 / Methyl Green; TDQ283MPCW / Eosine Yellowish-(YS)
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27. Celia A, Bruschi M, De Stefani S, Baisi B, Cesinaro AM, Micali S, Sighinolfi MC, Bianchi G: Bizarre leiomyoma of scrotum. Arch Ital Urol Androl; 2005 Jun;77(2):113-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bizarre leiomyoma of scrotum.
  • Genital leiomyomas of the scrotal skin are extremely rare benign tumors, originating from the tunica dartos of the scrotum.
  • We report our experience with one patients with scrotal bizarre leiomyoma.

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  • (PMID = 16146275.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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28. Amber I, Kennedy G, Martinez H, Pearson JM, Jimenez E: A leiomyoma in a cachectic woman presenting as a giant abdominal mass. J Radiol Case Rep; 2009;3(10):23-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A leiomyoma in a cachectic woman presenting as a giant abdominal mass.
  • However, after surgical evaluation, she was diagnosed pathologically with an atypical presentation of a uterine leiomyoma.

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  • [Cites] Arch Pathol Lab Med. 1999 Oct;123(10):960-2 [10506455.001]
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  • (PMID = 22470623.001).
  • [ISSN] 1943-0922
  • [Journal-full-title] Journal of radiology case reports
  • [ISO-abbreviation] J Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3303273
  • [Keywords] NOTNLM ; Fibroids / Leiomyoma / Pelvic Mass / cachexia / leiomyosarcoma
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29. Kim JH, Choi YJ, Kim DC, Lee SJ: Leiomyosarcoma arising in a patient with prior mitotically active leiomyoma. J Obstet Gynaecol Res; 2010 Feb;36(1):187-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyosarcoma arising in a patient with prior mitotically active leiomyoma.
  • Mitotically active leiomyomas exhibiting insignificant cytologic atypia (none to mild) with an increased mitotic count of 5-20 mitotic figures per 10 high power fields, and without coagulative tumor cell necrosis or atypical mitoses, tend to have a benign clinical course.
  • We encountered a case of a mitotically active leiomyoma and malignant transformation after a total hysterectomy.
  • The recurrent multiple abdominal masses were removed surgically; most of them were benign leiomyomas, but some were leiomyosarcomas.
  • Although most mitotically active leiomyomas have a benign clinical course, these lesions can recur and have the potential for malignant transformation.
  • Therefore, patients with mitotically active leiomyomas require close follow-up.
  • [MeSH-major] Abdominal Neoplasms / pathology. Leiomyoma / pathology. Leiomyosarcoma / pathology. Neoplasms, Second Primary / pathology. Uterine Neoplasms / pathology

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  • (PMID = 20178549.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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30. Ricci G, Inglese S, Candiotto A, Maso G, Piccoli M, Alberico S, Guaschino S: Ascites in puerperium: a rare case of atypical pseudo-Meigs' syndrome complicating the puerperium. Arch Gynecol Obstet; 2009 Dec;280(6):1033-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ascites in puerperium: a rare case of atypical pseudo-Meigs' syndrome complicating the puerperium.
  • A final diagnosis of atypical pseudo-Meigs' syndrome was performed, being computed tomography and chest X-ray negative for pleural effusion.
  • CONCLUSIONS: To the best of our knowledge, this is the first case of pseudo-Meigs' syndrome caused by a uterine leiomyoma described in puerperium and without hydrothorax.
  • [MeSH-major] Ascites / pathology. Leiomyoma / pathology. Meigs Syndrome / pathology. Uterine Neoplasms / pathology

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  • (PMID = 19322576.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-125 Antigen
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31. Sun X, Mittal K: MIB-1 (Ki-67), estrogen receptor, progesterone receptor, and p53 expression in atypical cells in uterine symplastic leiomyomas. Int J Gynecol Pathol; 2010 Jan;29(1):51-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MIB-1 (Ki-67), estrogen receptor, progesterone receptor, and p53 expression in atypical cells in uterine symplastic leiomyomas.
  • Nine cases of symplastic uterine leiomyomas were chosen from our files using strict criteria.
  • For each antigen, the percentages of positive atypical (bizarre) cells and nonatypical cells were compared.
  • The atypical cells had significantly higher percentages of cells expressing Ki-67 compared with nonatypical cells (17+/-20% vs. 3+/-3.9%).
  • Therefore, rather than being degenerative in nature, the atypical cells are actively proliferating.
  • [MeSH-major] Ki-67 Antigen / metabolism. Leiomyoma / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Tumor Suppressor Protein p53 / metabolism. Uterine Neoplasms / metabolism

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  • (PMID = 19952937.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / Tumor Suppressor Protein p53
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32. Stewart CJ, Leung YC, Mathew R, McCartney AL: Extrauterine adenomyoma with atypical (symplastic) smooth muscle cells: a report of 2 cases. Int J Gynecol Pathol; 2009 Jan;28(1):23-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extrauterine adenomyoma with atypical (symplastic) smooth muscle cells: a report of 2 cases.
  • They are uncommon in extrauterine sites and in this situation it may be unclear whether such lesions represent foci of endometriosis with marked smooth muscle hyperplasia/metaplasia, uteruslike mass lesions, or leiomyomas with entrapped endometriotic glandular and stromal elements.
  • In this report 2 cases of extrauterine adenomyoma are presented in which the smooth muscle component showed focal atypical (symplastic) cytologic appearances.
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / complications. Female. Humans. Leiomyoma / complications. Metrorrhagia / complications. Pelvic Inflammatory Disease / complications. Uterine Neoplasms / complications

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  • (PMID = 19047912.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Starczewski A, Brodowska A, Strojny K, Puchalski A, Mieczkowska E, Szydłowska I: [The value of ultrasonography in diagnosis of atypical endometrial hyperplasia in postmenopausal women]. Przegl Lek; 2005;62(4):227-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The value of ultrasonography in diagnosis of atypical endometrial hyperplasia in postmenopausal women].
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Leiomyoma / ultrasonography. Middle Aged. Polyps / ultrasonography. Predictive Value of Tests. Risk Factors. Women's Health

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  • (PMID = 16229240.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
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34. Alsinnawi M, Fleming FJ, Kenny BJ, Waldron D: Clinical images. Atypical midcycle pain. Am J Surg; 2009 Jan;197(1):e1-2
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  • [Title] Clinical images. Atypical midcycle pain.
  • [MeSH-major] Jejunal Neoplasms / diagnosis. Leiomyoma / diagnosis

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  • (PMID = 18723158.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Masood J, Voulgaris S, Atkinson P, Carr TW: A rare symplastic or bizarre leiomyoma of the scrotum: a case report and review of the literature. Cases J; 2008;1(1):381

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  • [Title] A rare symplastic or bizarre leiomyoma of the scrotum: a case report and review of the literature.
  • BACKGROUND: We present a case of a symplastic or "bizarre" leiomyoma of the scrotum.
  • Isolated cases of leiomyomas have been reported arising from the renal pelvis, bladder, spermatic cord, epididymis, prostate as well as the glans penis.
  • Because of its peculiar histological characteristics this tumour was assigned as a symplastic or bizarre leiomyoma of the scrotum.
  • This case demonstrates that leiomyomas should be considered in the differential diagnosis of scrotal tumours.

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  • [Cites] Arch Esp Urol. 2004 Oct;57(8):847-51 [15560276.001]
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  • (PMID = 19068127.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2633014
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36. Lee TK, Miyamoto H, Osunkoya AO, Guo CC, Weiss SW, Epstein JI: Smooth muscle neoplasms of the urinary bladder: a clinicopathologic study of 51 cases. Am J Surg Pathol; 2010 Apr;34(4):502-9
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  • We report the largest series to date examining the clinicopathologic features of leiomyomas and leiomyosarcomas of the bladder.
  • (1) How to distinguish leiomyomas of the bladder from normal muscularis propria on transurethral resection (TUR) specimens;.
  • (2) Whether symplastic leiomyomas can be diagnosed in the bladder;.
  • (3) Can leiomyoma be definitively diagnosed on biopsy or TUR without the risk of there being unsampled leiomyosarcoma; and (4) Is the grade of leiomyosarcoma seen on biopsy or TUR heterogeneous and hence possibly not representative of the true grade.
  • Thirty-one leiomyomas and 20 leiomyosarcoma cases of urinary bladder from 3 tertiary care medical centers were examined.
  • The mean age of the patients with leiomyoma and leiomyosarcoma was 52 and 58, respectively.
  • The M:F ratio was significantly higher in patients with leiomyosarcoma (2:1) compared with leiomyoma (1:3), p<0.005.
  • The specimen consisted of 20 TUR and 11 transurethral biopsies (TUBx) for leiomyomas, and 10 TUR, 3 TUBx, 5 cystectomies (Cyst), and 2 partial cystectomies (pCyst) for leiomyosarcomas.
  • LEIOMYOMAS: Notable features in leiomyomas were hyalinization (7/31), degenerative atypia (7/31), necrosis (4/31), myxoid changes (2/31), and focal fatty metaplasia (1/31); although no surface ulceration was identified.
  • Two patients had repeat TUR within a year of the initial diagnosis with the same bland leiomyoma on histology, probably reflecting persistence of earlier unresected tumor as opposed to recurrent tumor.
  • None of the cases of leiomyosarcomas had areas histologically resembling leiomyoma.
  • Leiomyoma (including symplastic leiomyoma) may be diagnosed on TUR without risk of underdiagnosing unsampled leiomyosarcoma.
  • [MeSH-major] Leiomyoma / pathology. Leiomyosarcoma / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 20154594.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Chen L, Yang B: Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. Int J Gynecol Pathol; 2008 Jul;27(3):326-32
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  • Despite well-established criteria, the distinction of uterine leiomyosarcoma from certain variants of benign leiomyoma, particularly bizarre leiomyoma, can be challenging morphologically.
  • However, the potential role of immunohistochemistry of p16, p53, and Ki-67 in the differential diagnosis of leiomyosarcoma and bizarre leiomyoma has not been well assessed.
  • We had immunohistochemically studied the expression of p16, p53, and Ki-67 proteins in 100 cases of uterine smooth muscle tumors, including 35 usual leiomyomas (LM), 13 cellular leiomyomas (CLM), 15 bizarre leiomyomas (BLM), 2 cases of smooth muscle tumor of uncertain malignant potential (STUMP), and 35 leiomyosarcoma (LMS).
  • [MeSH-major] Ki-67 Antigen / analysis. Leiomyoma / diagnosis. Leiomyosarcoma / diagnosis. Neoplasm Proteins / analysis. Tumor Suppressor Protein p53 / analysis. Uterine Neoplasms / diagnosis

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  • (PMID = 18580309.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / Tumor Suppressor Protein p53
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38. Ebert AD, Rosenow G, David M, Mechsner S, Magalov IS, Papadopoulos T: Co-occurrence of atypical endometriosis, subserous uterine leiomyomata, sactosalpinx, serous cystadenoma and bilateral hemorrhagic corpora lutea in a perimenopausal adipose patient taking tamoxifen (20 mg/day) for invasive lobular breast cancer. Gynecol Obstet Invest; 2008;66(3):209-13
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  • [Title] Co-occurrence of atypical endometriosis, subserous uterine leiomyomata, sactosalpinx, serous cystadenoma and bilateral hemorrhagic corpora lutea in a perimenopausal adipose patient taking tamoxifen (20 mg/day) for invasive lobular breast cancer.
  • BACKGROUND: For women taking tamoxifen, recent data strongly support the estrogen agonist role of tamoxifen as a causal factor for the increased risk of endometriosis, but also of leiomyomata, endometrial polyps, and endometrial hyperplasia.
  • During laparoscopy 2 uterine subserous leiomyomata, a right-sighted sactosalpinx, bilateral ovarian cysts, and an extended polypoid, vascularized endometriosis of the bladder peritoneum, the pelvic wall and Douglas pouch were found.
  • Complete pelvic deperitonealization, bilateral adnexectomy, and also enucleation of the 2 leiomyomata were performed.
  • The removed leiomyomata did not show atypia or significant mitotic activity.
  • [MeSH-major] Breast Neoplasms / drug therapy. Cystadenoma, Serous / chemically induced. Endometriosis / chemically induced. Fallopian Tube Diseases / chemically induced. Leiomyoma / chemically induced. Tamoxifen / adverse effects. Uterine Neoplasms / chemically induced


39. Goh SG, Dayrit JF, Calonje E: Symplastic hemangioma: report of two cases. J Cutan Pathol; 2006 Nov;33(11):735-40
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  • [Title] Symplastic hemangioma: report of two cases.
  • Symplastic hemangioma is characterized by degenerative atypia of vascular smooth muscle and interstitial cells within a pre-existing vascular lesion with minimal endothelial cell atypia.
  • The atypical cells, either located within the vascular smooth muscle wall or within the interstitium, were spindle or epithelioid with varying degrees of hyperchromasia, nuclear enlargement, pleomorphism, and multinucleation.
  • Rare atypical mitoses and occasional bizarre lipoblast-like stromal cells were identified in one tumor.
  • Immunohistochemistry showed focal smooth muscle actin positivity in the pleomorphic cells of the vascular walls.
  • The bizarre cytologic changes are interpreted as degenerative in nature and probably akin to that observed in ancient schwannoma and uterine symplastic leiomyoma.

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  • (PMID = 17083693.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
  • [Number-of-references] 31
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40. Gökaslan H, Türkeri L, Kavak ZN, Eren F, Sişmanoğlu A, Ilvan S, Durmuşoğlu F: Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors. Gynecol Obstet Invest; 2005;59(1):36-40
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  • MATERIAL AND METHOD: Seventeen samples of leiomyosarcoma, 2 smooth muscle tumors with uncertain malignant potential (STUMP), 9 atypical myomas and 15 leiomyomas were stained immunohistochemically.
  • The staining for progesterone receptor was also statistically significant, but the tumors that were considered benign, such as leiomyoma and atypical myoma, were the ones strongly stained (p = 0.005).

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15377824.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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41. Tahlan A, Nanda A, Mohan H: Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature. Int J Gynecol Pathol; 2006 Oct;25(4):361-5
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  • An associated leiomyoma was noted in 12 cases (46.9%).
  • Adenomyomas have to be distinguished from a number of other lesions, for example, adenomyosis, leiomyoma with entrapped glands, atypical polypoid adenomyoma, endometrial polyps, adenofibroma, and adenosarcoma.
  • [MeSH-minor] Adult. Female. Humans. Leiomyoma / pathology. Middle Aged. Uterine Cervical Neoplasms / pathology

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  • (PMID = 16990713.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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42. Hubert KC, Remer EM, Rackley RR, Goldman HB: Clinical and magnetic resonance imaging characteristics of vaginal and paraurethral leiomyomas: can they be diagnosed before surgery? BJU Int; 2010 Jun;105(12):1686-8
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  • [Title] Clinical and magnetic resonance imaging characteristics of vaginal and paraurethral leiomyomas: can they be diagnosed before surgery?
  • OBJECTIVE: To describe the clinical and magnetic resonance imaging (MRI) characteristics of vaginal and paraurethral leiomyomas.
  • PATIENTS AND METHODS: All patients with pathologically confirmed paraurethral and vaginal wall leiomyomas from January 2006 to August 2007 were reviewed.
  • In all cases, MRI excluded urethral diverticulae, and pathology showed leiomyoma, of which one had atypical features.
  • CONCLUSION: Paraurethral and vaginal wall leiomyomas can be identified before surgery with a reasonable degree of certainty, based on their clinical and MRI characteristics.
  • [MeSH-major] Leiomyoma / diagnosis. Magnetic Resonance Imaging. Urethral Neoplasms / diagnosis. Vaginal Neoplasms / diagnosis

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  • (PMID = 19889060.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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43. Schmidt T, Breidenbach M, Nawroth F, Mallmann P, Beyer IM, Fleisch MC, Rein DT: Hysteroscopy for asymptomatic postmenopausal women with sonographically thickened endometrium. Maturitas; 2009 Feb 20;62(2):176-8
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  • Hysteroscopy suggested the presence of endometrial polyps in 226 women (74.3%), simple endometrial hyperplasia in 34 (11.2%), atrophic endometrium in 18 (5.9%), complex endometrial hyperplasia in 2 (0.7%), atypical hyperplasia in 3 (1%) and leiomyoma in 9 (3.0%).
  • [MeSH-minor] Aged. Atrophy / diagnosis. Endometrium / pathology. Endometrium / ultrasonography. Female. Humans. Leiomyoma / diagnosis. Middle Aged. Polyps / diagnosis. Postmenopause. Prospective Studies. Risk Factors. Uterine Diseases / diagnosis

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  • (PMID = 19121901.001).
  • [ISSN] 0378-5122
  • [Journal-full-title] Maturitas
  • [ISO-abbreviation] Maturitas
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Ireland
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44. Semczuk A, Skorupski P, Olcha P, Skomra D, Rechberger T, Gogacz M: Giant uterine leiomyomas causing bilateral hydronephrosis coexisting with endometrial cancer in polyp: a case study. Eur J Gynaecol Oncol; 2009;30(3):344-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant uterine leiomyomas causing bilateral hydronephrosis coexisting with endometrial cancer in polyp: a case study.
  • Multiple uterine leiomyomas are present in a large population of women and may cause several uncommon clinical symptoms, including disseminated vein thrombosis and hydronephrosis.
  • We report a case of giant uterine leiomyomas causing bilateral hydronephrosis coexisting with endometrial cancer (EC) deriving from a uterine polyp.
  • Histopathological examination revealed multiple uterine leiomyomas with calcification and partial necrosis, and well-differentiated (G1), endometrioid-type EC (Stage IA) concomitant with atypical endometrial hyperplasia, deriving from a uterine polyp.
  • In conclusion, giant uterine leiomyoma may incidentally compress the urinary tract organs, causing hydronephrosis.
  • [MeSH-major] Endometrial Neoplasms / pathology. Hydronephrosis / etiology. Leiomyoma / pathology. Neoplasms, Multiple Primary / pathology. Polyps / pathology. Uterine Neoplasms / pathology

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  • (PMID = 19697639.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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45. Matsuoka S, Kikuchi I, Kitade M, Kumakiri J, Kuroda K, Tokita S, Kuroda M, Takeda S: Strategy for laparoscopic cervical myomectomy. J Minim Invasive Gynecol; 2010 May-Jun;17(3):301-5
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  • Histopathological examination showed atypical myoma in 1 case and leiomyoma in others.
  • [MeSH-minor] Adult. Blood Loss, Surgical. Female. Humans. Infertility, Female / surgery. Leiomyoma / surgery. Middle Aged. Myometrium / surgery. Treatment Outcome

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  • [Copyright] Copyright 2010 AAGL. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20303832.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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46. Parker RL, Young RH, Clement PB: Skeletal muscle-like and rhabdoid cells in uterine leiomyomas. Int J Gynecol Pathol; 2005 Oct;24(4):319-25
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  • [Title] Skeletal muscle-like and rhabdoid cells in uterine leiomyomas.
  • We describe eight unusual uterine leiomyomas characterized by a component of cells that suggested skeletal muscle differentiation or resembled the rhabdoid cells of extrarenal rhabdoid tumors.
  • The patients were aged 27 to 50 (mean, 38) years, and the presenting clinical features and gross appearance of the tumors were similar to those of typical uterine leiomyomas.
  • A variable number of the rhabdoid/skeletal muscle-like cells, as well as cells without these features, contained multiple or multilobed, pleomorphic, hyperchromatic nuclei, thus qualifying the tumors as leiomyomas with bizarre nuclei.
  • The histologic, immunohistochemical, and ultrastructural features indicated that the peculiar cells in these leiomyomas likely represented smooth muscle cells with an unusual phenotype rather than the cells of uterine tumors with skeletal muscle differentiation, extrarenal rhabdoid tumors, or epithelioid smooth muscle tumors.
  • An association with leiomyomas with bizarre nuclei also was suggested.
  • [MeSH-major] Leiomyoma / pathology. Muscle, Skeletal / pathology. Rhabdoid Tumor / pathology. Uterine Neoplasms / pathology

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  • (PMID = 16175075.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Hügel H: [Fibrohistiocytic skin tumors]. J Dtsch Dermatol Ges; 2006 Jul;4(7):544-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • "Fibrohistiocytic" means in this context the morphologic similarity of the cells with fibroblasts and histiocytes.
  • Variants of FH: 1a. cellular fibrous histiocytoma, 1b. atypical (pseudosarcomatous) fibrous histiocytoma, 1c. aneurysmatic fibrous histiocytoma, 1d. epithelioid fibrous histiocytoma; 2. dermatomyofibroma; 3. (juvenile) xanthogranuloma.
  • INTERMEDIATE: 4. plexiform fibrohistiocytic tumor; 5. dermatofibrosarcoma protuberans; 6. atypical Fibroxanthoma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / classification. Histiocytoma, Benign Fibrous / pathology. Leiomyoma / classification. Leiomyoma / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology

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  • (PMID = 16827912.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 53
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48. Golan A, Cohen-Sahar B, Keidar R, Condrea A, Ginath S, Sagiv R: Endometrial polyps: symptomatology, menopausal status and malignancy. Gynecol Obstet Invest; 2010;70(2):107-12
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  • Pathologic evaluation disclosed 7 cases of malignancy and 4 cases of atypical hyperplasia among bleeding postmenopausal women (11/263, 4%) and 2 malignancies and 3 cases of hyperplasia with atypia among asymptomatic postmenopausal women (5/378, 1.3%).
  • [MeSH-major] Endometrial Neoplasms / epidemiology. Leiomyoma / epidemiology. Menopause. Polyps / epidemiology. Precancerous Conditions / epidemiology. Premenopause

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20332644.001).
  • [ISSN] 1423-002X
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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49. Crauciuc E, Niculescu S, Balan R, Amălinei N, Flaişer C, Buţureanu S: [Giant uterine fibroma. Case report]. Rev Med Chir Soc Med Nat Iasi; 2008 Jan-Mar;112(1):148-51
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  • Sometimes the rare cases of giant uterine fibroma are met in medical practice and they need the use of atypical surgical techniques that are not entirely risk-free.
  • [MeSH-major] Hysterectomy. Leiomyoma. Uterine Neoplasms

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  • (PMID = 18677920.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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50. Karavolos S, Caplin M, Benjamin E, Crow J, Mould T: Primary mucinous carcinoid tumour of the ovary: a case report. Eur J Gynaecol Oncol; 2006;27(6):618-20
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  • We report a case of primary ovarian mucinous carcinoid tumour, of the atypical category, in a 34-year-old nulliparous woman.
  • This case adds to the body of evidence and demonstrates a possible good prognosis with non-aggressive behaviour in the atypical mucinous carcinoid group.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Leiomyoma / diagnosis. Prognosis. Treatment Outcome

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  • (PMID = 17290597.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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51. Tiufekchieva E: [Seven-year-experience in the hysteroresection of submucous myomas]. Akush Ginekol (Sofiia); 2007;46(4):23-8
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  • After 3 years 7 women, out of 31 observed, had abnormal bleeding; 5 women underwent hysterectomies because of intramural myomas, atypical endometrial hyperplasia, endometrial cancer, uterine prolapse.
  • [MeSH-major] Hysteroscopy. Leiomyoma / surgery. Uterine Neoplasms / surgery

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  • (PMID = 17974191.001).
  • [ISSN] 0324-0959
  • [Journal-full-title] Akusherstvo i ginekologii︠a︡
  • [ISO-abbreviation] Akush Ginekol (Sofiia)
  • [Language] bul
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Bulgaria
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52. Daum O, Hatlova J, Mandys V, Grossmann P, Mukensnabl P, Benes Z, Michal M: Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). Virchows Arch; 2010 May;456(5):491-7
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  • Atypical, inflammatory pseudotumor-like Vanek's tumor lacks concentric formations and is CD34 negative.
  • [MeSH-major] Intestinal Diseases / pathology. Leiomyoma / genetics. Leiomyoma / pathology. Polyps / genetics. Polyps / pathology. Receptor, Platelet-Derived Growth Factor alpha / genetics. Stomach Diseases / pathology

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  • (PMID = 20393746.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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53. Mutter GL, Bergeron C, Deligdisch L, Ferenczy A, Glant M, Merino M, Williams AR, Blithe DL: The spectrum of endometrial pathology induced by progesterone receptor modulators. Mod Pathol; 2008 May;21(5):591-8
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  • Progesterone receptor modulators (PRM) are hormonally active drugs effective in the management of endometriosis and uterine leiomyomata.
  • Overtly premalignant lesions (atypical hyperplasia or EIN) were not seen.
  • [MeSH-minor] Clinical Trials as Topic. Endometriosis / drug therapy. Female. Humans. Leiomyoma / drug therapy. Uterine Neoplasms / drug therapy

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  • (PMID = 18246050.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hormone Antagonists; 0 / Receptors, Progesterone
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54. Yoshida M, Nishikawa Y, Yamamoto Y, Doi Y, Tokairin T, Yoshioka T, Omori Y, Watanabe A, Takahashi N, Yoshioka T, Miura I, Sawada K, Enomoto K: Mast cell leukemia with rapidly progressing portal hypertension. Pathol Int; 2009 Nov;59(11):817-22
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  • Atypical mast cells (CD2+, CD25+, CD117+) with toluidine blue metachromasia were found in the peripheral blood and on bone marrow aspiration smears.
  • At autopsy the bone marrow, spleen, liver, and lymph nodes were extensively infiltrated by atypical tumor cells with occasional bi- or multi-lobated nuclei.
  • [MeSH-minor] Appendicitis / complications. Fatal Outcome. Female. Glomerulonephritis, IGA / complications. Humans. Leiomyoma / complications. Middle Aged. Ovarian Cysts / complications. Uterine Neoplasms / complications

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  • (PMID = 19883434.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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55. Ajit D, Gavas S, Jagtap S, Chinoy RF: Cytodiagnostic problems in cervicovaginal smears from symptomatic breast cancer patients on tamoxifen therapy. Acta Cytol; 2009 Jul-Aug;53(4):383-8
Hazardous Substances Data Bank. TAMOXIFEN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To evaluate the effect of tamoxifen on cervicovaginal epithelium, identify tamoxifen-related changes that mimic cancer and detennine the morphologic features differentiating the 2 changes.
  • Of 4 patients with a cytodiagnosis of atypical glandular changes, 2 had negative histology; 1 each had a uterine leiomyoma and endometrial hyperplasia.
  • Tamoxifen-associated cellular changes can mimic morphologic features of cancer.


56. Rizkalla HF, Higgins M, Kelehan P, O'Herlihy C: Pathological findings associated with the presence of a mirena intrauterine system at hysterectomy. Int J Gynecol Pathol; 2008 Jan;27(1):74-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thirty hysterectomy specimens contained benign leiomyomata with associated reduced reactivity in the uterine cavity and incomplete suppression of the endometrium.
  • In addition to leiomyomas, 1 specimen had an atypical polypoid adenomyoma and 1 had a benign adenomatoid tumor.
  • [MeSH-minor] Endometrial Hyperplasia / complications. Endometrial Hyperplasia / pathology. Endometriosis / complications. Endometriosis / pathology. Female. Humans. Hysterectomy. Leiomyoma / complications. Leiomyoma / pathology. Retrospective Studies. Treatment Failure. Uterine Neoplasms / complications. Uterine Neoplasms / pathology


57. Ribeiro CT, Rosa-E-Silva JC, Silva-de-Sá MF, Rosa-E-Silva AC, Poli Neto OB, Candido Dos Reis FJ, Nogueira AA: Hysteroscopy as a standard procedure for assessing endometrial lesions among postmenopausal women. Sao Paulo Med J; 2007 Nov 1;125(6):338-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathological analysis showed that 18 patients presented endometrial carcinoma or typical or atypical hyperplasia, and none of them presented endometrial thickness of less than 8 mm.
  • [MeSH-major] Endometrial Hyperplasia / pathology. Endometrial Neoplasms / pathology. Endometrium / pathology. Hysteroscopy / methods. Leiomyoma / pathology. Postmenopause

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  • (PMID = 18317604.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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58. Angioni S, Loddo A, Milano F, Piras B, Minerba L, Melis GB: Detection of benign intracavitary lesions in postmenopausal women with abnormal uterine bleeding: a prospective comparative study on outpatient hysteroscopy and blind biopsy. J Minim Invasive Gynecol; 2008 Jan-Feb;15(1):87-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All patients with pathologic reports of complex hyperplasia and atypical hyperplasia (20 patients) underwent vaginal hysterectomy with bilateral adnexectomy.
  • [MeSH-major] Biopsy, Needle / methods. Hysteroscopy / methods. Leiomyoma / diagnosis. Metrorrhagia / etiology. Uterine Neoplasms / diagnosis

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  • (PMID = 18262151.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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59. Kitajima K, Kaji Y, Imanaka K, Sugihara R, Sugimura K: MRI findings of uterine lipoleiomyoma correlated with pathologic findings. AJR Am J Roentgenol; 2007 Aug;189(2):W100-4
Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Even in an atypical case with a small volume of fat tissue in the mass, a fat-suppression MRI sequence is especially useful for the diagnosis.
  • [MeSH-major] Leiomyoma / diagnosis. Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Uterine Neoplasms / diagnosis

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  • (PMID = 17646431.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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60. Dursun P, Salman MC, Taskiran C, Yüce K, Ayhan A: Retroperitoneal leiomyomatosis: a case report. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1222-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Leiomyoma is the most common benign solid pelvic tumor seen in women.
  • Although it has been reported in various atypical localizations, they are extremely rare in the retroperitoneum.

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  • (PMID = 16343219.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Hong R, Choi DY, Choi SJ, Lim SC: Multicentric infarcted leiomyoadenomatoid tumor: a case report. Int J Clin Exp Pathol; 2009;2(1):99-103

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Laparoscopy-assisted transvaginal mass removal was performed under the clinical impression of a uterine leiomyoma and benign ovarian teratoma.
  • The microscopic appearance often suggested the possibility of a malignant neoplasm due to irregular pseudoinfiltration with atypical cuboidal cells and the paucity of a typical adenomatoid tumor due to infarction, and the presence of epithelial-appearing cells in the hypertrophic smooth muscle bundles that mimicked an infiltrating carcinoma for a leiomyoma or myometrium.

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  • (PMID = 18830386.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Leiomyoadenomatoid tumor / infarction / ovary / uterus
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62. Brun JL, André G, Descat E, Creux H, Vigier J, Dallay D: [Methods and efficacy of medical and surgical treatment of non functional menorrhagia]. J Gynecol Obstet Biol Reprod (Paris); 2008 Dec;37 Suppl 8:S368-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To assess the efficacy of therapies in menorrhagia related to atypical endometrial hyperplasia, polyps, myoma, adenomyosis and arteriovenous malformation of the uterus.
  • RESULTS: Atypical endometrial hyperplasia is classically treated by hysterectomy, but may temporarily regress under hormone therapy (progestins, Gn-RH agonists) in women of childbearing age.
  • However, hysterectomy remains the standard treatment of atypical endometrial hyperplasia and adenomyosis.
  • [MeSH-minor] Arteriovenous Malformations / complications. Arteriovenous Malformations / drug therapy. Arteriovenous Malformations / surgery. Embolization, Therapeutic. Endometrial Hyperplasia / complications. Endometrial Hyperplasia / drug therapy. Endometrial Hyperplasia / surgery. Endometriosis / complications. Endometriosis / drug therapy. Endometriosis / surgery. Female. Gonadotropin-Releasing Hormone / agonists. Humans. Hysterectomy. Hysteroscopy. Leiomyoma / complications. Leiomyoma / drug therapy. Leiomyoma / surgery. Polyps / complications. Polyps / drug therapy. Polyps / surgery. Pregnancy. Progestins / therapeutic use. Treatment Outcome. Uterine Neoplasms / complications. Uterine Neoplasms / drug therapy. Uterine Neoplasms / surgery. Uterus / blood supply

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  • (PMID = 19268216.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Progestins; 33515-09-2 / Gonadotropin-Releasing Hormone
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63. Cornfeld D, Israel G, Martel M, Weinreb J, Schwartz P, McCarthy S: MRI appearance of mesenchymal tumors of the uterus. Eur J Radiol; 2010 Apr;74(1):241-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Uterine leiomyomas are the most common uterine neoplasms.
  • Statistically, a uterine mass with unusual imaging features is more likely to represent a leiomyoma than other uncommon uterine mesenchymal neoplasms such as leiomyosarcoma or endometrial stromal tumors.
  • Seventeen additional control cases of leiomyomas were selected as controls.
  • CONCLUSION: We found poor accuracy for objective imaging criteria in distinguishing leiomyomas with atypical imaging features from more clinically significant uterine mesenchymal neoplasms.

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19349135.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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64. Kroencke TJ, Scheurig C, Kluner C, Taupitz M, Schnorr J, Hamm B: Uterine fibroids: contrast-enhanced MR angiography to predict ovarian artery supply--initial experience. Radiology; 2006 Oct;241(1):181-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: MR angiography depicted 18 ovarian arteries (four bilateral, 10 unilateral), one with an atypical origin.
  • [MeSH-major] Leiomyoma / blood supply. Magnetic Resonance Angiography / methods. Ovary / blood supply. Uterine Neoplasms / blood supply

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  • [Copyright] (c) RSNA, 2006.
  • (PMID = 16908679.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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65. Newbold RR, Jefferson WN, Padilla-Banks E: Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract. Reprod Toxicol; 2007 Aug-Sep;24(2):253-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • More severe pathologies of the uterus following neonatal BPA treatment included adenomyosis, leiomyomas, atypical hyperplasia, and stromal polyps.
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / pathology. Animals. Animals, Newborn. Animals, Outbred Strains. Benzhydryl Compounds. Body Weight / drug effects. Corpus Luteum / drug effects. Corpus Luteum / pathology. Dose-Response Relationship, Drug. Endometrial Hyperplasia / chemically induced. Endometrial Hyperplasia / pathology. Endometriosis / chemically induced. Endometriosis / pathology. Estrogens, Non-Steroidal / administration & dosage. Estrogens, Non-Steroidal / toxicity. Female. Injections, Subcutaneous. Leiomyoma / chemically induced. Leiomyoma / pathology. Male. Mice. Ovarian Cysts / chemically induced. Ovarian Cysts / pathology. Oviducts / drug effects. Oviducts / pathology. Pregnancy. Time Factors. Uterine Neoplasms / chemically induced. Uterine Neoplasms / pathology. Uterus / drug effects. Uterus / pathology

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  • (PMID = 17804194.001).
  • [ISSN] 0890-6238
  • [Journal-full-title] Reproductive toxicology (Elmsford, N.Y.)
  • [ISO-abbreviation] Reprod. Toxicol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 ES070060-34
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Estrogens, Non-Steroidal; 0 / Phenols; MLT3645I99 / bisphenol A
  • [Other-IDs] NLM/ NIHMS31723; NLM/ PMC2043380
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66. Toon C, McGahan S, Henderson P, Russell P: Myxoid symplastic leiomyoma of the uterus. Pathology; 2006 Jun;38(3):275-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid symplastic leiomyoma of the uterus.
  • [MeSH-major] Leiomyoma / pathology. Myxoma / pathology. Uterine Neoplasms / pathology

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  • (PMID = 16753760.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin
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67. Kanavi MR, Soheilian M, Peyman GA: Ciliary body leiomyoma with atypical features. Can J Ophthalmol; 2007 Apr;42(2):336-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ciliary body leiomyoma with atypical features.

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  • (PMID = 17392872.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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68. Wang JY, Liu LF, Yan JL, Mao XH, Lao LM: Pilar leiomyoma with cytological atypia: cutaneous counterpart of atypical uterine leiomyoma? Clin Exp Dermatol; 2010 Jul;35(5):550-1
MedlinePlus Health Information. consumer health - Uterine Fibroids.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilar leiomyoma with cytological atypia: cutaneous counterpart of atypical uterine leiomyoma?
  • [MeSH-major] Leiomyoma / pathology. Skin Neoplasms / pathology. Uterine Neoplasms / pathology

  • Genetic Alliance. consumer health - Uterine Fibroid.
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  • (PMID = 19874346.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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69. Gupta N, Dadhwal V, Misra R, Mittal S, Kiran S: Atypical presentation of a leiomyoma as spontaneous massive haemoperitoneum. Eur J Obstet Gynecol Reprod Biol; 2008 May;138(1):120-1
MedlinePlus Health Information. consumer health - Uterine Fibroids.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical presentation of a leiomyoma as spontaneous massive haemoperitoneum.
  • [MeSH-major] Hemoperitoneum / etiology. Leiomyoma / surgery. Uterine Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - Uterine Cancer.
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  • (PMID = 17386968.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
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70. Matsushita M, Okazaki K: Atypical EUS features of gastric inflammatory fibroid polyps. Gastrointest Endosc; 2005 Apr;61(4):637-8; author reply 638
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical EUS features of gastric inflammatory fibroid polyps.
  • [MeSH-major] Endosonography. Gastritis / ultrasonography. Leiomyoma / ultrasonography. Polyps / ultrasonography. Stomach Neoplasms / ultrasonography

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  • [CommentOn] Gastrointest Endosc. 2004 Nov;60(5):802-3 [15557964.001]
  • (PMID = 15812432.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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71. Novellas S, Bafghi A, Caramella T, Chevallier A, Bongain A, Chevallier P, Bruneton J: [Uterine lipoleiomyoma: atypical MR imaging features]. J Radiol; 2008 Dec;89(12):1941-3
MedlinePlus Health Information. consumer health - Uterine Fibroids.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Uterine lipoleiomyoma: atypical MR imaging features].
  • [MeSH-major] Leiomyoma / diagnosis. Magnetic Resonance Imaging. Uterine Neoplasms / diagnosis

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  • (PMID = 19106853.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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72. Son HJ, Jang KY, Kim DK, Cho NP, Moon WS: Bizarre leiomyoma of the soft tissue. Pathology; 2005 Aug;37(4):318-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bizarre leiomyoma of the soft tissue.
  • [MeSH-major] Leiomyoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16194835.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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73. Vlahos N, Economopoulos K, Skarpidi E, Moraitis D: Bizarre leiomyoma of the posterior vaginal fornix. Int J Gynaecol Obstet; 2008 Sep;102(3):296-7
MedlinePlus Health Information. consumer health - Vaginal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bizarre leiomyoma of the posterior vaginal fornix.
  • [MeSH-major] Leiomyoma / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18501906.001).
  • [ISSN] 0020-7292
  • [Journal-full-title] International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • [ISO-abbreviation] Int J Gynaecol Obstet
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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