[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 156
1. Sakamoto A: Atypical fibroxanthoma. Clin Med Oncol; 2008;2:117-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma.
  • Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis.
  • AFX most commonly occurs on sun-exposed skin in elderly individuals.
  • Making a diagnosis of AFX is challenging, and it is important to differentiate it from squamous cell carcinoma and malignant melanoma.
  • Histological features and combined immunohistochemical markers are necessary for a definitive diagnosis (i.e., an absence of immunostaining for cytokeratins, S100 and HMB45 in AFX is helpful for excluding both squamous cell carcinoma and malignant melanoma).
  • AFX, as well as MFH (malignant fibrous histiocytoma), is a fibrohistiocytic lesion with myofibroblastic differentiation.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Virchows Arch. 2002 Apr;440(4):404-9 [11956822.001]
  • [Cites] Dermatology. 1999;198(1):29-32 [10026398.001]
  • [Cites] Cancer. 1975 Feb;35(2):457-63 [122913.001]
  • [Cites] J Cutan Pathol. 2003 May;30(5):336-9 [12753176.001]
  • [Cites] J Cutan Pathol. 2004 Jan;31(1):57-61 [14675286.001]
  • [Cites] Anticancer Res. 2004 Jan-Feb;24(1):19-26 [15015571.001]
  • [Cites] Australas J Dermatol. 2004 May;45(2):106-9 [15068457.001]
  • [Cites] Virchows Arch. 2005 Mar;446(3):251-8 [15731925.001]
  • [Cites] J Cutan Pathol. 2005 Apr;32(4):314-7 [15769283.001]
  • [Cites] Am J Dermatopathol. 2005 Apr;27(2):181 [15798451.001]
  • [Cites] Cancer. 1992 Jun 15;69(12):2942-52 [1591688.001]
  • [Cites] Australas J Dermatol. 2005 Nov;46(4):235-8 [16197421.001]
  • [Cites] J Cutan Pathol. 2006 Apr;33(4):318-22 [16630185.001]
  • [Cites] Dermatol Surg. 2006 Mar;32(3):435-41; discussion 439-41 [16640694.001]
  • [Cites] J Cutan Pathol. 2006 Sep;33(9):614-8 [16965335.001]
  • [Cites] J Cutan Pathol. 2006 Sep;33 Suppl 2:24-8 [16972949.001]
  • [Cites] J Cutan Pathol. 2007 May;34(5):415-9 [17448198.001]
  • [Cites] Mod Pathol. 1999 Nov;12(11):1072-7 [10574605.001]
  • [Cites] Br J Dermatol. 2000 Sep;143(3):618-20 [10971340.001]
  • [Cites] Anticancer Res. 2000 Sep- Oct;20(5B):3539-44 [11131659.001]
  • [Cites] Am J Otolaryngol. 2001 Jan-Feb;22(1):73-5 [11172219.001]
  • [Cites] J Am Acad Dermatol. 2001 Apr;44(4):656-9 [11260542.001]
  • [Cites] Hum Pathol. 2001 Nov;32(11):1225-31 [11727262.001]
  • [Cites] J Cutan Pathol. 2004 Mar;31(3):284-6 [14984584.001]
  • [Cites] Dermatol Surg. 2004 Dec;30(12 Pt 2):1561-4 [15606841.001]
  • [Cites] J Cutan Pathol. 2006 Feb;33(2):186-8 [16420318.001]
  • [Cites] J Cutan Pathol. 2006 Oct;33(10):663-6 [17026517.001]
  • [Cites] Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10124-8 [1946433.001]
  • [Cites] Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9455-9 [7568153.001]
  • [Cites] Cell. 1995 Jun 30;81(7):1013-20 [7600570.001]
  • [Cites] Am J Pathol. 1994 Jul;145(1):11-7 [8030743.001]
  • [Cites] Am J Dermatopathol. 1997 Jun;19(3):228-31 [9185907.001]
  • [Cites] Med J Aust. 1998 Apr 20;168(8):418-9 [9594957.001]
  • [Cites] Mod Pathol. 2001 Jun;14(6):581-8 [11406660.001]
  • [Cites] Am J Clin Pathol. 2002 Jan;117(1):126-31 [11789717.001]
  • [Cites] Histopathology. 2007 Jun;50(7):939-41 [17543084.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1990;417(5):377-88 [2173252.001]
  • [Cites] J Photochem Photobiol B. 1989 Oct;4(1):21-34 [2509659.001]
  • [Cites] J Dermatol Surg Oncol. 1989 Dec;15(12):1287-92 [2556464.001]
  • [Cites] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5574-8 [271984.001]
  • [Cites] J Cutan Pathol. 1988 Aug;15(4):201-7 [3053811.001]
  • [Cites] Pathol Res Pract. 1987 Jun;182(3):443-7 [3306632.001]
  • [Cites] Br J Dermatol. 1977 Aug;97(2):167-77 [334235.001]
  • [Cites] J Cutan Pathol. 1988 Apr;15(2):120-3 [3372789.001]
  • [Cites] Am J Surg Pathol. 1988 Aug;12(8):591-8 [3400790.001]
  • [Cites] Arch Dermatol. 1985 Jun;121(6):753-5 [3890760.001]
  • [Cites] J Mol Biol. 1985 Mar 5;182(1):45-65 [3923204.001]
  • [Cites] Cancer. 1986 Jan 15;57(2):368-76 [3942970.001]
  • [Cites] Cancer. 1973 Jun;31(6):1541-52 [4709969.001]
  • [Cites] Nature. 1980 Feb 7;283(5747):583-5 [6928257.001]
  • [Cites] Histopathology. 1993 Mar;22(3):247-54 [7684354.001]
  • [Cites] Cancer. 1995 Mar 1;75(5):1128-34 [7850711.001]
  • [Cites] Am J Surg Pathol. 1993 Dec;17(12):1199-209 [8238729.001]
  • [Cites] J Cutan Pathol. 1993 Jun;20(3):211-5 [8396160.001]
  • [Cites] Dermatol Surg. 1996 Mar;22(3):268-73 [8599739.001]
  • [Cites] J Am Acad Dermatol. 1996 Aug;35(2 Pt 1):262-4 [8708032.001]
  • [Cites] Dermatology. 1996;192(4):411-3 [8864396.001]
  • [Cites] Biochemistry. 1996 Dec 10;35(49):15693-703 [8961932.001]
  • [Cites] Photochem Photobiol. 1997 Feb;65(2):270-83 [9066304.001]
  • [Cites] Dermatol Surg. 1997 Feb;23(2):105-10 [9107284.001]
  • [Cites] Cancer. 1997 Jun 1;79(11):2115-24 [9179057.001]
  • [Cites] J Cell Biol. 1998 Jan 12;140(1):171-82 [9425165.001]
  • [Cites] Dermatol Surg. 1997 Dec;23(12):1223-4 [9426678.001]
  • [Cites] J Cutan Pathol. 2002 Jul;29(6):374-81 [12135470.001]
  • (PMID = 21892274.001).
  • [ISSN] 1177-9314
  • [Journal-full-title] Clinical medicine. Oncology
  • [ISO-abbreviation] Clin Med Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3161641
  • [Keywords] NOTNLM ; atypical fibroxanthoma / malignant fibrous histiocytoma / malignant melanoma / squamous cell carcinoma
  •  go-up   go-down


2. Vandergriff TW, Reed JA, Orengo IF: An unusual presentation of atypical fibroxanthoma. Dermatol Online J; 2008;14(1):6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual presentation of atypical fibroxanthoma.
  • Atypical fibroxanthoma (AFX) is a rare cutaneous spindle-cell neoplasm.
  • The tumor occurs most commonly in sun-damaged skin of the head and neck in elderly patients.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18319023.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


3. Sakamoto A, Akieda S, Oda Y, Iwamoto Y, Tsuneyoshi M: Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthoma. BMC Dermatol; 2009;9:1
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthoma.
  • BACKGROUND: Atypical fibroxanthoma (AFX) histologically mimics high-grade sarcoma in the skin, although it follows a benign clinical course.
  • AFX occurs in the sun-exposed skin and for this reason, an association with ultraviolet light has long been suspected.
  • METHODS: Immunohistochemical expression of Bax was analyzed in 7 cases of AFX, and in 7 cases of benign fibrous histiocytoma (BFH) used as a comparison.
  • [MeSH-major] Cell Cycle Proteins / genetics. Histiocytoma, Benign Fibrous / genetics. Nuclear Proteins / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adolescent. Aged. Aged, 80 and over. DNA Mutational Analysis. Exons / genetics. Female. Humans. Immunohistochemistry. Male. Middle Aged. Skin / metabolism. Skin / pathology. bcl-2-Associated X Protein / metabolism

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Br J Dermatol. 2000 Sep;143(3):618-20 [10971340.001]
  • [Cites] Histopathology. 2007 Jun;50(7):939-41 [17543084.001]
  • [Cites] Nature. 2000 Nov 16;408(6810):307-10 [11099028.001]
  • [Cites] Mod Pathol. 2001 Jun;14(6):581-8 [11406660.001]
  • [Cites] Oncogene. 2001 Oct 11;20(46):6784-93 [11709713.001]
  • [Cites] Hum Pathol. 2001 Nov;32(11):1225-31 [11727262.001]
  • [Cites] Eur Respir J. 2002 Jan;19(1):134-40 [11843312.001]
  • [Cites] Int J Mol Med. 2002 Aug;10(2):161-8 [12119552.001]
  • [Cites] Clin Cancer Res. 2002 Aug;8(8):2563-9 [12171884.001]
  • [Cites] Gynecol Oncol. 2004 Jan;92(1):71-9 [14751141.001]
  • [Cites] J Cutan Pathol. 2004 Mar;31(3):284-6 [14984584.001]
  • [Cites] Biochim Biophys Acta. 2004 Mar 1;1644(2-3):229-49 [14996506.001]
  • [Cites] Cancer. 1973 Jun;31(6):1541-52 [4709969.001]
  • [Cites] Acta Pathol Microbiol Scand A. 1976 Mar;84(2):183-97 [1258644.001]
  • [Cites] Histopathology. 1993 Mar;22(3):247-54 [7684354.001]
  • [Cites] J Cutan Pathol. 1993 Jun;20(3):211-5 [8396160.001]
  • [Cites] Am J Pathol. 1994 Jul;145(1):11-7 [8030743.001]
  • [Cites] Cancer. 1995 Mar 1;75(5):1128-34 [7850711.001]
  • [Cites] Genes Dev. 1996 May 1;10(9):1054-72 [8654922.001]
  • [Cites] Hum Genet. 1996 Apr;97(4):543-7 [8834260.001]
  • [Cites] Biochemistry. 1996 Dec 10;35(49):15693-703 [8961932.001]
  • [Cites] Nature. 1997 Feb 13;385(6617):637-40 [9024662.001]
  • [Cites] Cancer. 1997 Jun 1;79(11):2115-24 [9179057.001]
  • [Cites] Am J Dermatopathol. 1997 Jun;19(3):228-31 [9185907.001]
  • [Cites] Anticancer Res. 1997 May-Jun;17(3C):2233-40 [9216694.001]
  • [Cites] J Cell Biol. 1998 Jan 12;140(1):171-82 [9425165.001]
  • [Cites] J Neurosci. 1998 Feb 15;18(4):1363-73 [9454845.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3706-11 [10097101.001]
  • [Cites] Cell. 1999 May 28;97(5):575-86 [10367887.001]
  • [Cites] Nat Genet. 1999 Oct;23(2):176-84 [10508513.001]
  • [Cites] Am J Dermatopathol. 2005 Apr;27(2):181 [15798451.001]
  • [Cites] Int J Gynecol Cancer. 2005 May-Jun;15(3):453-61 [15882169.001]
  • [Cites] J Cutan Pathol. 2006 Sep;33 Suppl 2:24-8 [16972949.001]
  • [Cites] J Cutan Pathol. 2007 May;34(5):415-9 [17448198.001]
  • [Cites] Cell Prolif. 2000 Oct;33(5):301-6 [11063132.001]
  • (PMID = 19128509.001).
  • [ISSN] 1471-5945
  • [Journal-full-title] BMC dermatology
  • [ISO-abbreviation] BMC Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / GADD45A protein, human; 0 / Nuclear Proteins; 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC2628644
  •  go-up   go-down


Advertisement
4. Kijima Y, Umekita Y, Yoshinaka H, Taguchi S, Owaki T, Funasako Y, Sakamoto A, Yoshida H, Aikou T: Stromal sarcoma with features of giant cell malignant fibrous histiocytoma. Breast Cancer; 2007;14(2):239-44
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stromal sarcoma with features of giant cell malignant fibrous histiocytoma.
  • We report a case of primary giant cell malignant fibrous histiocytoma (GCMFH) of the breast.
  • Mammography and ultrasonography revealed a well-circumscribed and lobulated mass in the upper outer quadrant of the right breast, indicative of a benign breast tumor or mucinous carcinoma.
  • Fine needle aspiration biopsy showed several clusters of atypical cells associated with numerous multinucleated giant cells.
  • [MeSH-major] Breast Neoplasms / pathology. Giant Cell Tumors / pathology. Histiocytoma, Malignant Fibrous / pathology

  • Genetic Alliance. consumer health - Malignant fibrous histiocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17485912.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 28
  •  go-up   go-down


5. Sugitani M, Aramaki O, Kikuchi K, Sheikh A, Oinuma T, Mamiya T, Takayama T, Nemoto N: Two cases of primary malignant fibrous histiocytoma of the liver: immunohistochemical expression of ezrin and its relationship with prognosis. Acta Histochem Cytochem; 2009 Jun 27;42(3):83-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two cases of primary malignant fibrous histiocytoma of the liver: immunohistochemical expression of ezrin and its relationship with prognosis.
  • Malignant fibrous histiocytoma (MFH) as soft tissue sarcoma would not be especially noteworthy, but primary hepatic MFH reports are extremely rare.
  • Microscopically, the tumors of these two cases were similar and showed proliferation of atypical cells, including spindle, pleomorphic and multi-nucleated giant cells arranged in storiform, sheet and/or fascicle patterns, with scattered foci of inflammatory cells, indicating MFH.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer. 1964 Nov;17:1445-55 [14223761.001]
  • [Cites] Mt Sinai J Med. 2005 Jan;72(1):50-2 [15682264.001]
  • [Cites] Cancer. 1986 Jun 15;57(12):2323-4 [3008981.001]
  • [Cites] Am J Gastroenterol. 1985 Oct;80(10):813-5 [2994468.001]
  • [Cites] Gastroenterology. 1985 Oct;89(4):890-3 [2993091.001]
  • [Cites] Cancer. 1978 Jun;41(6):2250-66 [207408.001]
  • [Cites] Nat Med. 2004 Feb;10(2):182-6 [14704791.001]
  • [Cites] Nat Med. 2004 Feb;10(2):175-81 [14704789.001]
  • [Cites] Gynecol Oncol. 2003 Aug;90(2):273-81 [12893187.001]
  • [Cites] Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2442-9 [11581181.001]
  • [Cites] Cancer Res. 2001 May 1;61(9):3750-9 [11325848.001]
  • [Cites] Am J Pathol. 2000 Dec;157(6):1785-93 [11106550.001]
  • [Cites] Hum Pathol. 2008 Dec;39(12):1737-43 [18701134.001]
  • [Cites] Am J Surg Pathol. 2008 Aug;32(8):1144-58 [18545143.001]
  • [Cites] World J Gastroenterol. 2007 Dec 21;13(47):6441-3 [18081238.001]
  • [Cites] J Surg Oncol. 2007 Oct 1;96(5):419-23 [17874463.001]
  • [Cites] Histol Histopathol. 2007 Dec;22(12):1337-42 [17701913.001]
  • [Cites] J Clin Pathol. 2007 Feb;60(2):185-9 [16698950.001]
  • [Cites] Hepatobiliary Pancreat Dis Int. 2006 Nov;5(4):620-3 [17085355.001]
  • [Cites] Int J Gynecol Pathol. 2006 Apr;25(2):121-30 [16633060.001]
  • [Cites] Clin Cancer Res. 2005 Sep 1;11(17):6198-204 [16144921.001]
  • [Cites] Biochem Biophys Res Commun. 1999 May 10;258(2):395-400 [10329398.001]
  • (PMID = 19617955.001).
  • [ISSN] 0044-5991
  • [Journal-full-title] Acta histochemica et cytochemica
  • [ISO-abbreviation] Acta Histochem Cytochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2711395
  • [Keywords] NOTNLM ; ezrin / liver / malignant fibrous histiocytoma / prognosis
  •  go-up   go-down


6. Guillou L: [Mesenchymal tumors of the skin. Atypical fibrous histiocytoma]. Ann Pathol; 2009 Oct;29(5):411-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mesenchymal tumors of the skin. Atypical fibrous histiocytoma].
  • [Transliterated title] Tumeurs conjonctives de la peau. Cas n(o) 7. Histiocytome fibreux atypique.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20004844.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  •  go-up   go-down


7. Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL: Subcutaneous atypical fibrous histiocytoma. Am J Dermatopathol; 2009 Jul;31(5):499-501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subcutaneous atypical fibrous histiocytoma.
  • Benign fibrous histiocytoma is one of the most frequent benign neoplasms mainly composed of a mixture of fibroblastic and histiocytic cells, especially found in the skin (dermatofibroma), particularly in the limbs.
  • The diagnosis of cutaneous benign fibrous histiocytoma is generally easy; however, rare variants may be difficult to identify, and the diagnosis only confirmed after exhaustive histopathological examination.
  • Thus, deep subcutaneous dermatofibroma may be difficult to distinguish from dermatofibrosarcoma protuberans and dermatofibroma with monster giant cells from malignant fibrous histiocytoma and atypical fibroxanthoma.
  • We report a case of a 38-year-old woman with a painless swelling on the abdominal wall, which was totally excised and histopathologically diagnosed as subcutaneous atypical fibrous histiocytoma.
  • Definitive diagnosis, although especially difficult in our case, is established by characteristic histological and immunohistochemical criteria.
  • To the best of our knowledge, we report the first case of subcutaneous fibrous histiocytoma with monster cells.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Soft Tissue Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19542931.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


8. Luzar B, Calonje E: Cutaneous fibrohistiocytic tumours - an update. Histopathology; 2010 Jan;56(1):148-65
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous fibrohistiocytic tumours - an update.
  • The term 'fibrohistiocytic' tumour is a descriptive designation without histogenetic connotation for a group of heterogeneous lesions that share morphological features of histiocytes and fibroblasts on light microscopy.
  • However, over the years it has become apparent that many so-called 'fibrohistiocytic' tumours are largely composed of relatively undifferentiated mesenchymal cells, but can also show areas of myofibroblastic differentiation.
  • This review focuses on the clinical and histological features as well as differential diagnosis of so-called fibrohistiocytic tumours.
  • Special emphasis is given to more recently described histological variants of fibrous histiocytoma, e.g. cellular, epithelioid, aneurysmal and atypical fibrous histiocytoma, to angiomatous and plexiform fibrous histocytoma (plexiform fibrohistiocytic tumour), lesions that are not true variants of fibrous histiocytomas but have erroneously been designated such, and to atypical fibroxanthoma.
  • The literature on metastasizing fibrous histiocytoma is also reviewed.
  • [MeSH-major] Histiocytoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Skin / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20055912.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 120
  •  go-up   go-down


9. Akbulut M, Zekioglu O, Ozdemir N, Kapkac M: Fine needle aspiration cytology of mammary carcinoma with choriocarcinomatous features: a report of 2 cases. Acta Cytol; 2008 Jan-Feb;52(1):99-104
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Neoplasms of the breast containing multinucleated giant cells (MGCs) include both benign and malignant entities, such as benign soft tissue giant cell tumors, atypical fibrous histiocytoma, sarcomas, metaplastic carcinomas and the uncommon carcinomas containing osteoclast-like giant cells (OGC).
  • Although rare, FNAC of breast cancer with pleomorphic MGC requires careful search for differential diagnosis; breast carcinoma with giant cell features (choriocarcinomatous features, OGC features) must be differentiated from metastatic tumors and other breast lesions containing giant cells.
  • [MeSH-major] Breast Neoplasms / diagnosis. Choriocarcinoma / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18323284.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


10. Bose AC, Kate V, Ananthakrishnan N, Srinivasan S: Primary cutaneous malignant fibrous histiocytoma: a case report. Med Sci Monit; 2006 Jul;12(7):CS61-3
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous malignant fibrous histiocytoma: a case report.
  • BACKGROUND: Malignant fibrous histiocytoma (MFH) is one of the commonest soft tissue sarcomas to occur in the extremities, but presentation as a primary cutaneous lesion is rare.
  • MFH can present as a cutaneous lesion in the form of a primary tumor or as metastasis from MFH at other sites, such as primary MFH of the breast; however, both presentations are very rare.
  • CASE REPORT: We report here a 55-year-old male patient with cutaneous MFH on the right thigh region.
  • CONCLUSIONS: Although MFH is one of the commonest soft tissue sarcomas, cutaneous presentation is very rare.
  • MFH variants such as atypical fibrous histiocytoma or atypical fibroxanthoma can occur sometimes as cutaneous MFH.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / diagnosis. Skin Neoplasms / diagnosis

  • Genetic Alliance. consumer health - Malignant fibrous histiocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16810139.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  •  go-up   go-down


11. Koch M, Dimmler A, Alexiou C: [Recurrent and metastasizing atypical fibroxanthoma]. HNO; 2008 Oct;56(10):1046-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent and metastasizing atypical fibroxanthoma].
  • [Transliterated title] Rezidivierendes und metastasierendes atypisches Fibroxanthom.
  • Atypical fibroxanthoma is a rare skin tumor that arises particularly on sun-exposed skin.
  • The accurate classification of aggressive processes of atypical fibroxanthoma is currently still the subject of discussion.
  • The case of an 81-year-old patient with relapsing atypical fibroxanthoma of the right auricle is presented.
  • Atypical fibroxanthoma and the appropriate therapy for it are described, and the newest discoveries regarding this disease are discussed on the basis of the current literature.
  • [MeSH-major] Ear Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Neoplasm Recurrence, Local / surgery. Parotid Neoplasms / secondary. Parotid Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Pathol. 1994 Jul;145(1):11-7 [8030743.001]
  • [Cites] Semin Cutan Med Surg. 1998 Jun;17(2):141-52 [9669607.001]
  • [Cites] Am J Surg Pathol. 1993 Dec;17(12):1199-209 [8238729.001]
  • [Cites] Acta Pathol Microbiol Scand A. 1976 Mar;84(2):183-97 [1258644.001]
  • [Cites] Dermatol Surg. 1997 Feb;23(2):105-10 [9107284.001]
  • [Cites] Australas J Dermatol. 2004 May;45(2):106-9 [15068457.001]
  • [Cites] Dermatol Surg. 2006 Apr;32(4):588-91 [16681672.001]
  • [Cites] Arch Dermatol. 1978 Oct;114(10):1533-5 [718196.001]
  • [Cites] Pathol Res Pract. 1987 Jun;182(3):443-7 [3306632.001]
  • [Cites] Cancer. 1995 Mar 1;75(5):1128-34 [7850711.001]
  • [Cites] J Cutan Pathol. 1993 Jun;20(3):211-5 [8396160.001]
  • [Cites] Mod Pathol. 2001 Jun;14(6):581-8 [11406660.001]
  • [Cites] Ann Otol Rhinol Laryngol. 2001 Oct;110(10):985-7 [11642435.001]
  • [Cites] J Cutan Pathol. 2004 Jan;31(1):57-61 [14675286.001]
  • [Cites] Cancer. 1997 Jun 1;79(11):2115-24 [9179057.001]
  • [Cites] Head Neck. 2001 May;23(5):399-403 [11295814.001]
  • [Cites] Med J Aust. 1998 Apr 20;168(8):418-9 [9594957.001]
  • [Cites] Cancer. 1973 Jun;31(6):1541-52 [4709969.001]
  • [Cites] Anticancer Res. 2003 Mar-Apr;23(2C):1847-51 [12820468.001]
  • [Cites] Plast Reconstr Surg. 2003 Apr 15;111(5):1760-2 [12655231.001]
  • [Cites] J Cutan Pathol. 2006 Apr;33(4):318-22 [16630185.001]
  • [Cites] Cancer. 1975 Feb;35(2):457-63 [122913.001]
  • [Cites] Australas J Dermatol. 2005 Nov;46(4):235-8 [16197421.001]
  • [Cites] Arch Pathol Lab Med. 2006 Jun;130(6):831-4 [16740036.001]
  • [Cites] Hum Pathol. 2001 Nov;32(11):1225-31 [11727262.001]
  • [Cites] Am J Dermatopathol. 2005 Apr;27(2):181 [15798451.001]
  • [Cites] Dermatol Surg. 2004 Dec;30(12 Pt 2):1561-4 [15606841.001]
  • [Cites] Am J Surg Pathol. 2006 Aug;30(8):1041-6 [16861978.001]
  • [Cites] Dermatol Surg. 2005 Feb;31(2):221-5; discussion 225 [15762219.001]
  • [Cites] Am J Otolaryngol. 2001 Jan-Feb;22(1):73-5 [11172219.001]
  • [Cites] Cancer. 1986 Jan 15;57(2):368-76 [3942970.001]
  • [Cites] Semin Cutan Med Surg. 1999 Mar;18(1):78-83 [10188846.001]
  • [Cites] Am J Dermatopathol. 1985 Feb;7(1):57-63 [3977021.001]
  • [Cites] Am J Clin Pathol. 2002 Jan;117(1):126-31 [11789717.001]
  • [Cites] Dermatol Surg. 2006 Mar;32(3):435-41; discussion 439-41 [16640694.001]
  • [Cites] J Dermatol Surg Oncol. 1989 Dec;15(12):1287-92 [2556464.001]
  • [Cites] Arch Pathol Lab Med. 2006 May;130(5):735-6 [16683896.001]
  • (PMID = 18210006.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


12. Mirza B, Weedon D: Atypical fibroxanthoma: a clinicopathological study of 89 cases. Australas J Dermatol; 2005 Nov;46(4):235-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma: a clinicopathological study of 89 cases.
  • Atypical fibroxanthoma is a controversial entity with a disputed histogenesis.
  • It has recently been suggested that most atypical fibroxanthoma are actually variants of squamous cell carcinoma.
  • We reviewed 100 purported cases of atypical fibroxanthoma received over 4 years to perform clinical follow up and immunohistochemical markers.
  • A further case was interpreted as a malignant fibrous histiocytoma.
  • Our cases were typical of the usual clinical presentation of atypical fibroxanthoma on the skin of the sun-damaged elderly.
  • We found no cases of recurrent or metastatic atypical fibroxanthoma.
  • Two patients developed a second primary atypical fibroxanthoma.
  • CD10 proved to be a useful marker for atypical fibroxanthoma when used on 20 cases in the present study, as was CD99 in seven cases.
  • It had dual features of atypical fibroxanthoma and squamous cell carcinoma.
  • However, as the majority of atypical fibroxanthoma had no adjacent solar keratosis, our data suggest it is unlikely that atypical fibroxanthoma is a variant of squamous cell carcinoma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16197421.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  •  go-up   go-down


13. Marcet S: Atypical fibroxanthoma/malignant fibrous histiocytoma. Dermatol Ther; 2008 Nov-Dec;21(6):424-7
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma/malignant fibrous histiocytoma.
  • Atypical fibroxanthoma (AFX) is an unusual spindle cell tumor occurring on actinically damaged skin of the head and neck.
  • Although initially thought to be a diagnosis of exclusion histologically, newer immunostains have helped in the identification of AFX.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Humans. Mohs Surgery. Neoplasm Recurrence, Local


14. Kohlhof JK, Müller-Richter U, Driemel O, Sachs H: [Pleomorphic malignant fibrous histiocytoma of the periorbital region]. Klin Monbl Augenheilkd; 2007 Mar;224(3):203-6
Genetic Alliance. consumer health - Pleomorphic malignant fibrous histiocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic malignant fibrous histiocytoma of the periorbital region].
  • BACKGROUND: Pleomorphic malignant fibrous histiocytomas (undifferentiated pleomorphic sarcomas) belong to the soft tissue tumours and are more likely in elder patients.
  • About 3 % percent of all pleomorphic malignant fibrous histiocytomas arise in the head and neck region.
  • PATIENT: A 91 year old female patient presented because of a prominent tumour in the upper right periorbital region.
  • A biopsy was classified as a malignant fibrous tumour with the subclassification of an atypical fibroxanthoma.
  • Therefore the tumour classification was changed to pleomorphic malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma).
  • The defect was closed with a full skin graft on the basis of a galea periosteal flap.
  • CONCLUSION: The histopathological examination could not provide the correct diagnosis initially.
  • In the process of finding the right diagnosis sometimes a change from benign to malignant occurs and alters the treatment regime.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / radiography. Orbital Neoplasms / pathology. Orbital Neoplasms / radiography

  • Genetic Alliance. consumer health - Malignant fibrous histiocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17385123.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


15. Hartel PH, Jackson J, Ducatman BS, Zhang P: CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker. J Cutan Pathol; 2006 Sep;33 Suppl 2:24-8
Genetic Alliance. consumer health - Pleomorphic malignant fibrous histiocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker.
  • Atypical fibroxanthoma (AFX), a benign lesion, and pleomorphic malignant fibrous histiocytoma (MFH) are thought to represent points along the same neoplastic spectrum but with different prognoses and treatments.
  • Diagnosis based on histology and clinical parameters alone is sometimes difficult, and a reliable cost-effective immunohistochemical marker to help distinguish these lesions would be beneficial.
  • The diagnosis of AFX or MFH was based upon published clinical and microscopic criteria.
  • [MeSH-major] Antigens, CD / biosynthesis. Biomarkers, Tumor / biosynthesis. Cell Adhesion Molecules / biosynthesis. Fibroma / metabolism. Fibroma / pathology. Gene Expression Regulation, Neoplastic. Histiocytoma, Malignant Fibrous / metabolism. Histiocytoma, Malignant Fibrous / pathology. Xanthomatosis / metabolism. Xanthomatosis / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

  • Genetic Alliance. consumer health - Malignant fibrous histiocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16972949.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
  •  go-up   go-down


16. Stepanova A, Marsch WC, Stadie V: [A rare low-grade malignant scalp tumor. Atypical fibroxanthoma]. Hautarzt; 2005 Jul;56(7):679-82
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A rare low-grade malignant scalp tumor. Atypical fibroxanthoma].
  • [Transliterated title] Seltener niedrig-maligner Tumor der Kopfhaut. Atypisches Fibroxanthom.
  • Based on clinical, histological and immunohistochemical staining, we made the diagnosis of an atypical fibroxanthoma (AFX).
  • AFX is a rare tumor, but important in the differential diagnosis of other scalp tumors.
  • The routine histological staining allows one to identify a malignant fibrous histiocytoma, while a spindle-cell malignant melanoma can be excluded with immunohistochemical staining.
  • An anaplastic squamous cell carcinoma cannot always be separated with completed certainty from atypical fibroxanthoma.
  • AFX is a low-grade malignant tumor and most cases behave in a benign fashion.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Scalp / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Surg Pathol. 1993 Dec;17(12):1199-209 [8238729.001]
  • [Cites] Am J Surg Pathol. 2002 Jan;26(1):35-46 [11756767.001]
  • [Cites] Br J Dermatol. 2000 Sep;143(3):618-20 [10971340.001]
  • [Cites] J Cutan Pathol. 1992 Aug;19(4):268-77 [1331210.001]
  • [Cites] Hautarzt. 1980 Apr;31(4):213-5 [7399914.001]
  • [Cites] Cancer. 1986 Jan 15;57(2):368-76 [3942970.001]
  • [Cites] Eur J Dermatol. 1998 Mar;8(2):122-4 [9649666.001]
  • [Cites] Semin Cutan Med Surg. 1999 Mar;18(1):78-83 [10188846.001]
  • [Cites] Histopathology. 1987 May;11(5):463-75 [3497085.001]
  • [Cites] Pathol Res Pract. 1988 Dec;184(1):27-34 [3266010.001]
  • (PMID = 15726303.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


17. Khong JJ, Chen CS, James CL, Huilgol SC, O'Donnell BA, Sullivan TJ, Selva D: Malignant fibrous histiocytoma of the eyelid: differential diagnosis and management. Ophthal Plast Reconstr Surg; 2005 Mar;21(2):103-8
Genetic Alliance. consumer health - Malignant fibrous histiocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant fibrous histiocytoma of the eyelid: differential diagnosis and management.
  • PURPOSE: Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma that occurs rarely in the periocular region.
  • The purpose of this study was to present a case series of periocular MFH and to discuss the differential diagnosis and management.
  • The initial diagnoses were sarcomatoid carcinoma, atypical fibroxanthoma, and leiomyosarcoma that were subsequently reclassified as MFH.
  • CONCLUSIONS: This study highlights the difficulties in the clinicopathologic diagnosis of periocular MFH and in particular the distinction of more superficial tumors from atypical fibroxanthoma.
  • [MeSH-major] Eyelid Neoplasms / diagnosis. Eyelid Neoplasms / surgery. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local. Ophthalmologic Surgical Procedures. Radiotherapy, Adjuvant. Retrospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15778662.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


18. Gómez de la Fuente E, Sols M, Pinedo F, Alvarez-Fernández JG, Vicente FJ, Naz E, López-Estebaranz JL: [Atypical fibroxanthoma. Clinical/pathological study of 10 cases]. Actas Dermosifiliogr; 2005 Apr;96(3):153-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Atypical fibroxanthoma. Clinical/pathological study of 10 cases].
  • [Transliterated title] Fibroxantoma atípico. Estudio clinicopatológico de 10 casos.
  • INTRODUCTION: Atypical fibroxanthoma (AFX) is a rare tumor of unknown histogenesis, considered by most authorities as a superficial form of malignant fibrous histiocytoma (MFH).
  • Clinical (age, onset-diagnosis time, location, accompanying pathology, outcome), histological (architectural pattern, cell type, ulceration, vascular or perineural invasion, subcutis involvement, pleomorphism, mitosis, inflammatory infiltrate) and immunohistochemical variable were analyzed.
  • CASES REPORT: Clinical and epidemiological features coincide with those previously reported: onset late in life, short time onset-diagnosis, involvement of skin with notable sun damage and a good outcome.
  • DISCUSSION: The diagnosis of AXF is always of exclusion.
  • Other spindle-cell tumors such as squamous cell carcinoma, malignant melanoma, leyomiosarcoma or dermatofibrosarcoma protuberans must be ruled out by immunohistochemical techniques.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16476356.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


19. Fussell JN, Cooke ER, Florentino F, Sheehan DJ: Atypical fibroxanthoma with keloidal collagen. Am J Dermatopathol; 2010 Oct;32(7):713-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma with keloidal collagen.
  • Atypical fibroxanthoma (AFX) is a lesion that typically occurs on actinically damaged skin of the head and neck.
  • Histopathology of these neoplasms reveals atypical cells, which often demonstrate positive staining for immunohistochemical markers such as vimentin and CD10.
  • [MeSH-major] Collagen Type I / biosynthesis. Histiocytoma, Benign Fibrous / pathology. Procollagen / biosynthesis. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20700041.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / Procollagen; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


20. Kim UR, Arora V, Shanti R, Shah AD: Neglected giant atypical fibroxanthoma of the eyelid. Ophthal Plast Reconstr Surg; 2009 Sep-Oct;25(5):408-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neglected giant atypical fibroxanthoma of the eyelid.
  • Atypical fibroxanthoma is an uncommon neoplasm of the superficial soft tissue that occurs in actinically damaged skin of elderly patients.
  • The authors present an unusual case of neglected giant atypical fibroxanthoma of the eyelid in an elderly patient.
  • [MeSH-major] Eyelid Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19966663.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


21. Cooper JZ, Newman SR, Scott GA, Brown MD: Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases. Dermatol Surg; 2005 Feb;31(2):221-5; discussion 225
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases.
  • BACKGROUND: Atypical fibroxanthoma (AFX) is an unusual malignant fibrohistiocytic tumor of sun-damaged skin.
  • When first described, it was felt to be a reactive tumor of low malignant potential.
  • More recently, it has been shown to be a tumor of intermediate malignant potential.
  • Also, three of the five cases had other aggressive cutaneous malignancies.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Face / pathology. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Metastasis. Scalp / pathology. Upper Extremity / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15762219.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


22. Rudisaile SN, Hurt MA, Santa Cruz DJ: Granular cell atypical fibroxanthoma. J Cutan Pathol; 2005 Apr;32(4):314-7
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell atypical fibroxanthoma.
  • We report on two patients with granular cell atypical fibroxanthoma.
  • Immunohistochemical stains were positive for CD68 and vimentin and negative for Melan-A or human melanoma black (HMB)-45, S-100 protein, pancytokeratin, and actin, consistent with atypical fibroxanthoma.
  • The differential diagnosis of granular cells in neoplasms containing cytological pleomorphism is challenging in view of the many different neoplasms that may present with granular cytoplasm.
  • These include the conventional granular cell tumor and its malignant form, leiomyoma, leiomyosarcoma, dermatofibroma, dermatofibrosarcoma protuberans, and angiosarcoma.
  • [MeSH-major] Granular Cell Tumor / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15769283.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 25
  •  go-up   go-down


23. Sangüeza M, Zelger B: Melanoma simulating atypical fibroxanthoma. Am J Dermatopathol; 2007 Dec;29(6):551-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma simulating atypical fibroxanthoma.
  • Melanoma may present with a wide variety of clinicopathological presentations, among those very rarely lesions imitating atypical fibroxanthoma (AFX).
  • The present series describes 4 cases of such melanomas in 3 patients whose exact diagnosis was (markedly) delayed due to unusual clinicopathological presentations including negative immunohistochemistry for melanocytic markers (S100 protein, MelanA/MART1, HMB45).
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Diagnostic Errors / prevention & control. Fatal Outcome. Female. Humans. Male. Neoplasm Recurrence, Local

  • MedlinePlus Health Information. consumer health - Melanoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18032950.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


24. Dettrick A, Strutton G: Atypical fibroxanthoma with perineural or intraneural invasion: report of two cases. J Cutan Pathol; 2006 Apr;33(4):318-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma with perineural or intraneural invasion: report of two cases.
  • We report two cases of atypical fibroxanthoma (AFX) that both had the previously unreported feature of neural invasion (one perineural and the other intraneural).
  • Some authors would regard such cases as malignant fibrous histiocytoma (MFH) because of such deep extension; however, the concept of AFX as a superficial variant of MFH is outmoded--AFX is a distinct clinicopathologic entity with established clinical, histological, and immunohistochemical features.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Neurons / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Peripheral Nervous System Neoplasms / secondary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16630185.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


25. Stefanato CM, Robson A, Calonje JE: The histopathologic spectrum of regression in atypical fibroxanthoma. J Cutan Pathol; 2010 Mar;37(3):310-5
Faculty of 1000. commentaries/discussion - See the articles recommended by F1000Prime's Faculty of more than 8,000 leading experts in Biology and Medicine. (subscription/membership/fee required).

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The histopathologic spectrum of regression in atypical fibroxanthoma.
  • BACKGROUND: Atypical fibroxanthoma (AFX) with prominent fibrosis, sclerosis and hyalinization, and near-total tumor regression is rare.
  • Advanced fibrosis, in the absence of a history of prior trauma or surgery, may indicate spontaneous regression.
  • These cases emphasize the importance of recognizing this subset of AFX in order to avoid misinterpretation, particularly in cases with few residual atypical cells.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19765173.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


26. Lum DJ, King AR: Peritoneal metastases from an atypical fibroxanthoma. Am J Surg Pathol; 2006 Aug;30(8):1041-6
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peritoneal metastases from an atypical fibroxanthoma.
  • Atypical fibroxanthoma (AFX) is a mesenchymal neoplasm usually occurring in sun-exposed skin of elderly patients.
  • Histology of the scalp lesion showed a markedly pleomorphic neoplasm characteristic of AFX.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Malignant Fibrous / secondary. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Aged, 80 and over. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Scalp / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16861978.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


27. Mathew RA, Schlauder SM, Calder KB, Morgan MB: CD117 immunoreactivity in atypical fibroxanthoma. Am J Dermatopathol; 2008 Feb;30(1):34-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD117 immunoreactivity in atypical fibroxanthoma.
  • Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly.
  • [MeSH-major] Biomarkers, Tumor / analysis. Histiocytoma, Benign Fibrous / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis. Skin Neoplasms / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Am J Dermatopathol. 2008 Aug;30(4):401-2 [18645317.001]
  • [CommentIn] Am J Dermatopathol. 2009 Feb;31(1):96-8 [19155737.001]
  • [CommentIn] Am J Dermatopathol. 2008 Dec;30(6):640-2 [19033951.001]
  • (PMID = 18212542.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  •  go-up   go-down


28. Youker SR, Billingsley EM: Combined Merkel cell carcinoma and atypical fibroxanthoma. J Cutan Med Surg; 2005 Jan;9(1):6-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined Merkel cell carcinoma and atypical fibroxanthoma.
  • BACKGROUND: Although there are reports of squamous cell carcinoma arising within and adjacent to Merkel cell carcinoma, and one report of an atypical fibroxanthoma-like tumor arising in an irradiated recurrent Merkel cell carcinoma, there have previously been no reports of an immunohistochemically verified atypical fibroxanthoma occurring in conjunction with a Merkel cell carcinoma.
  • OBJECTIVE: We report on a neoplasm with distinct features of both Merkel cell carcinoma and atypical fibroxanthoma.
  • RESULTS: Our results verify the finding of a combined Merkel cell carcinoma and atypical fibroxanthoma.
  • [MeSH-major] Carcinoma, Merkel Cell / diagnosis. Histiocytoma, Malignant Fibrous / diagnosis. Lip Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16208439.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


29. Bugatti L, Filosa G: Dermatoscopic features of cutaneous atypical fibroxanthoma: three cases. Clin Exp Dermatol; 2009 Dec;34(8):e898-900
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermatoscopic features of cutaneous atypical fibroxanthoma: three cases.
  • Atypical fibroxanthoma (AFX) is an uncommon, low-grade, malignant, spindle-cell tumour of fibrohistiocytic histogenesis, which can mimic other malignant skin tumours, such as basal and squamous cell carcinoma (CC), melanoma, and Merkel cell carcinoma (MCC).
  • Three cases of AFX were examined by dermatoscopy, which revealed white areas and an atypical polymorphous vascular pattern characterized by the concurrence of different structures: linear, dotted, hairpin, arborescent and highly tortuous vessels, irregularly distributed over the surface.
  • AFX may be added to the list of slightly pigmented, reddish, malignant cutaneous tumours, such as SCC, MCC, amelanotic/hypomelanotic melanoma and eccrine porocarcinoma, which display prominent and chaotic dermatoscopic neoangiogenetic features in more advanced stages of proliferation.
  • [MeSH-major] Dermoscopy / methods. Histiocytoma, Benign Fibrous / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male

  • MedlinePlus Health Information. consumer health - Melanoma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20055861.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


30. Mochizuki K, Yamada T, Mori Y, Sawada A, Mori I, Ohnishi Y: Case of atypical fibroxanthoma in the palpebral conjunctiva. Jpn J Ophthalmol; 2008 Sep-Oct;52(5):404-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case of atypical fibroxanthoma in the palpebral conjunctiva.
  • BACKGROUND: We report a case of atypical fibroxanthoma that developed in the palpebral conjunctiva.
  • From these findings, we diagnosed the tumor as an atypical fibroxanthoma.
  • CONCLUSIONS: An atypical fibroxanthoma in the palpebral conjunctiva is very rare.
  • The clinical presentation and histological and immunohistochemical studies are helpful in distinguishing between an atypical fibroxanthoma and a malignant fibrous histiocytoma.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / analysis. Conjunctival Diseases. Cryosurgery. Female. Humans. Neoplasm Proteins / analysis. Xanthomatosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18991043.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  •  go-up   go-down


31. Kim J, McNiff JM: Keloidal atypical fibroxanthoma: a case series. J Cutan Pathol; 2009 May;36(5):535-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Keloidal atypical fibroxanthoma: a case series.
  • BACKGROUND: Keloidal atypical fibroxanthoma (AFX) is a rare variant of AFX with thick bands of hyalinized collagen.
  • The identification of keloidal collagen associated with fibrohistiocytic cells may erroneously lead to the diagnosis of keloidal dermatofibroma.
  • Although AFX is a pleomorphic cutaneous tumor typically associated with a good prognosis, occasional reports of metastatic AFX highlight the importance of accurate identification.
  • CONCLUSIONS: The diagnosis of keloidal AFX requires the exclusion of other malignant and benign lesions with keloidal or sclerotic collagen.
  • Awareness of the rare variant of keloidal AFX may avoid a diagnostic pitfall leading to an erroneous diagnosis, particularly in small biopsies.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Keloid / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, CD31 / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19476521.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
  •  go-up   go-down


32. Nakai N, Takenaka H, Kishimoto S: Atypical fibroxanthoma on a bald scalp. J Dermatol; 2005 Oct;32(10):848-51
MedlinePlus Health Information. consumer health - Dandruff, Cradle Cap, and Other Scalp Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma on a bald scalp.
  • We present the clinical, histopathological and immunohistochemical findings of an atypical fibroxanthoma (AFX) on the bald scalp of an 81-year-old French man who had worked at a private high school in Japan as a janitor for over 40 years.
  • This case therefore provides further support to the theory that AFX displays a clinically benign course, even though it is essentially a malignant tumor histologically located in the dermis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Scalp Dermatoses / pathology
  • [MeSH-minor] Aged, 80 and over. Alopecia / complications. Head and Neck Neoplasms / complications. Head and Neck Neoplasms / pathology. Humans. Male. Scalp. Skin Neoplasms / complications. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16361741.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


33. Wylie J, Hampton N, Telfer MR, Clarke AM: Atypical fibroxanthoma: Case series of 16 patients. Br J Oral Maxillofac Surg; 2010 Sep;48(6):466-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma: Case series of 16 patients.
  • Atypical fibroxanthoma is an unusual tumour of skin seen mainly in the head and neck region of elderly patients.
  • Immunohistochemical analysis also aids diagnosis.
  • We present a case series of 16 patients with 17 atypical fibroxanthomas over a 5-year period in a district general hospital.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Retrospective Studies. Scalp / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20129724.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  •  go-up   go-down


34. Arsenovic N, Sen S, Naik V, Reed M, Moreira R: Trichilemmal cyst with carcinoma in situ within an atypical fibroxanthoma. Am J Dermatopathol; 2009 Aug;31(6):587-90
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trichilemmal cyst with carcinoma in situ within an atypical fibroxanthoma.
  • A 91-year-old lady presented with an 8-month history of a slow growing keratotic nodule on the forehead, which was excised.
  • Therefore, the lesion was designated as atypical fibroxanthoma (AFX) by exclusion.
  • [MeSH-major] Carcinoma in Situ / pathology. Epidermal Cyst / pathology. Histiocytoma, Benign Fibrous / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Diseases / metabolism. Skin Diseases / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19590414.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


35. Wright NA, Thomas CG, Calame A, Cockerell CJ: Granular cell atypical fibroxanthoma: case report and review of the literature. J Cutan Pathol; 2010 Mar;37(3):380-5
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell atypical fibroxanthoma: case report and review of the literature.
  • We present a case of granular cell atypical fibroxanthoma of the scalp.
  • The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man.
  • Histology demonstrated a diffuse proliferation of atypical epithelioid cells with abundant granular cytoplasm.
  • Many of the cells had large irregular nuclei and atypical mitotic figures were present.
  • The granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarcoma protuberans, fibrous papules, basal cell carcinomas, leiomyosarcomas, angiosarcomas and primitive polypoid granular cell tumors.
  • We discuss the differential diagnosis and review the previously reported cases of this rare variant of atypical fibroxanthoma.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19341433.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


36. Hultgren TL, DiMaio DJ: Immunohistochemical staining of CD10 in atypical fibroxanthomas. J Cutan Pathol; 2007 May;34(5):415-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical staining of CD10 in atypical fibroxanthomas.
  • BACKGROUND: The histologic diagnosis of atypical fibroxanthoma (AFX) may be difficult at times with a differential diagnosis including spindle cell/desmoplastic melanoma and a poorly differentiated squamous cell carcinoma (SCC).
  • While there are immunohistochemical stains that may be used to support a diagnosis of either melanoma or carcinoma, the diagnosis of AFX tends to be one of exclusion.
  • [MeSH-major] Biomarkers, Tumor / analysis. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Neprilysin / biosynthesis. Skin Neoplasms / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Melanoma / metabolism. Melanoma / pathology. Middle Aged

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17448198.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


37. Castillo M, Sanjuán A, Pérez N, Zanón G, Bons N, Vilanova M, Vanrell JA, Merino MJ, Fernández PL: Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. Int J Surg Pathol; 2006 Jan;14(1):89-93
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing.
  • We report the case of a 19-year-old pregnant woman who presented with a nipple tumor.
  • The lesion consisted in a spindle-cell proliferation with histologic features similar to those of fibrous histiocytoma, with a highly vascularized stroma.
  • Although it showed low mitotic activity, scattered marked atypical cells with prominent nucleoli were identified, thus raising concern about the benign nature of the tumor.
  • To our knowledge this is the first reported case of a lesion of this type in the nipple after body-piercing.
  • [MeSH-major] Body Piercing / adverse effects. Breast Neoplasms / diagnosis. Breast Neoplasms / etiology. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / etiology. Nipples / pathology. Pregnancy Complications, Neoplastic / diagnosis

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • MedlinePlus Health Information. consumer health - Tumors and Pregnancy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Int J Surg Pathol 14(1):89-93, 2006.
  • (PMID = 16501844.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Vimentin
  •  go-up   go-down


38. Pajak J, Ograbek-Król M, Dobrosz Z, Pierzchała W: [Primary cardiac malignant fibrous histiocytoma in 47-year-old woman]. Wiad Lek; 2005;58(5-6):345-9
Genetic Alliance. consumer health - Malignant fibrous histiocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary cardiac malignant fibrous histiocytoma in 47-year-old woman].
  • A case of pleomorphic malignant fibrous histiocytoma of the right atrium and right ventricle is presented.
  • Primary cardiac malignant fibrous histiocytoma (MFH) is extremely rare and its etiology and clinical course are not precisely known.
  • Microscopically, atypical fibroblast-like cells, pleomorphic and multinucleated giant tumor cells with eosinophilic cytoplasm were observed within the myxoid and fibrous stroma.
  • [MeSH-major] Heart Neoplasms. Histiocytoma, Malignant Fibrous

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16238131.001).
  • [ISSN] 0043-5147
  • [Journal-full-title] Wiadomości lekarskie (Warsaw, Poland : 1960)
  • [ISO-abbreviation] Wiad. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  •  go-up   go-down


39. Shao L, Newell B, Quintanilla N: Atypical fibroxanthoma and squamous cell carcinoma of the conjunctiva in xeroderma pigmentosum. Pediatr Dev Pathol; 2007 Mar-Apr;10(2):149-52
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma and squamous cell carcinoma of the conjunctiva in xeroderma pigmentosum.
  • Patients with xeroderma pigmentosum (XP) have defective DNA repair and a high predisposition to developing abnormalities and neoplasia in the sun-exposed areas of the skin and mucous membranes.
  • Atypical fibroxanthoma (AFX) is a pleomorphic tumor that arises predominantly in the sun-damaged skin of the head and neck regions of the elderly.
  • We describe a unique case of a 6-year-old African American boy with XP who developed an atypical fibroxanthoma and 2 squamous cell carcinomas in the conjunctiva.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Conjunctiva / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xeroderma Pigmentosum / pathology

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • Genetic Alliance. consumer health - Xeroderma pigmentosum.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17378688.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Tumor Suppressor Protein p53; 0 / Vimentin
  •  go-up   go-down


40. Gil T, Sabo E, Kerner H, Metanes I, Har-Shai Y: Atypical fibroxanthoma of the scalp following hair transplantation in a 35-year-old male. J Plast Reconstr Aesthet Surg; 2010 Oct;63(10):e725-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma of the scalp following hair transplantation in a 35-year-old male.
  • Atypical fibroxanthoma (AFX) is an uncommon spindle cell neoplasm of the elderly.
  • This case report presents an atypical case of AFX of the scalp 8 years after hair transplantation in a 35-year-old male patient.
  • To the best of our knowledge, this case report is the first description in the medical literature of development of skin malignancy on a hair-transplanted scalp.
  • [MeSH-major] Alopecia / surgery. Hair / transplantation. Histiocytoma, Benign Fibrous / surgery. Lasers, Gas / adverse effects. Scalp Dermatoses / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Skin Transplantation / methods

  • Genetic Alliance. consumer health - Transplantation.
  • MedlinePlus Health Information. consumer health - Dandruff, Cradle Cap, and Other Scalp Conditions.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20673656.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  •  go-up   go-down


41. McGregor DH, Cherian R, Romanas MM, Ulusarac O, Mathur SC, Feldman MM: Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma. Ann Clin Lab Sci; 2008;38(2):157-62
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma.
  • Collision (contiguous) tumors of the skin can result in misleading clinicopathological presentations, and the choice of appropriate diagnostic techniques may prevent incomplete diagnosis and management.
  • We report 2 cases of collision tumors involving amelanotic malignant melanoma of the back.
  • This lesion was composed of 2 distinct contiguous neoplastic infiltrates, the predominant component being an atypical fibroxanthoma and the smaller component an amelanotic melanoma (primary vs metastatic), with diagnostic confirmation requiring multiple immunohistochemical stains.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma, Amelanotic / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18469362.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
  •  go-up   go-down


42. Luzar B, Calonje E: Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: a review. J Cutan Pathol; 2010 Mar;37(3):301-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: a review.
  • The present manuscript gives emphasis on recognizing different morphological variants of atypical fibroxanthoma (AFX), on validation of immunohistochemical markers and on discussing potential diagnostic pitfalls.
  • MATERIAL AND METHODS: Histological features analyzed in 66 AFXs were: ulceration, morphological variants, growth pattern, location in the skin and vascular/perineural invasion.
  • All developed on sun damaged skin.
  • An expansile (36.4%) rather than infiltrative (6.1%) growth into superficial subcutis was also noted.
  • CONCLUSIONS: A diagnosis of AFX is still made by exclusion of other malignant neoplasms with similar morphology.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Arm / pathology. Biomarkers, Tumor. Diagnosis, Differential. Female. Fibrosis / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Scalp / pathology. Sex Factors

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Cutan Pathol. 2011 Aug;38(8):679-80 [21518383.001]
  • [CommentIn] J Cutan Pathol. 2010 Mar;37(3):299-300 [20458783.001]
  • (PMID = 19807823.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


43. Murali R, Palfreeman S: Clear cell atypical fibroxanthoma - report of a case with review of the literature. J Cutan Pathol; 2006 May;33(5):343-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell atypical fibroxanthoma - report of a case with review of the literature.
  • Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of atypical fibroxanthoma (AFX), a pleomorphic dermal tumour associated with a good prognosis.
  • The immunohistochemical and ultrastructural features supported a diagnosis of CCAFX.
  • The diagnosis of CCAFX requires the exclusion of other pleomorphic clear cell tumours that can occur in the skin by using a combination of morphology, immunohistochemistry and electronmicroscopy.
  • Clear cell atypical fibroxanthoma - report of a case with review of the literature.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16640540.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


44. Pastor-Nieto MA, Kilmurray LG, Requena L: [Pigmented or hemosiderotic atypical fibroxanthoma]. Actas Dermosifiliogr; 2009 May;100(4):321-4
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pigmented or hemosiderotic atypical fibroxanthoma].
  • [Transliterated title] Fibroxantoma atípico pigmentado o hemosiderótico.
  • Pigmented atypical fibroxanthoma is a rare variant of atypical fibroxanthoma and is characterized by extensive areas of hemorrhage, erythrophagocytosis, and hemosiderin accumulation in the cytoplasm of the neoplastic cells.
  • It affects elderly individuals and presents as irregularly pigmented, dome-shaped nodules or plaques on areas of skin exposed to the sun.
  • We present a case of pigmented atypical fibroxanthoma on the cheek of an 81-year-old man.
  • The 9 cases of pigmented atypical fibroxanthoma reported in the literature are reviewed, and the histopathological features and differential diagnosis are discussed.
  • [MeSH-major] Hemosiderosis / etiology. Skin Diseases / complications. Xanthomatosis / complications

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19463236.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
  •  go-up   go-down


45. Avshalumov K, Williford P, Sangueza OP, Goldenberg G: Atypical fibroxanthoma presenting in a patient with stage III mycosis fungoides. J Dermatolog Treat; 2008;19(2):118-20
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma presenting in a patient with stage III mycosis fungoides.
  • The association of atypical fibroxanthoma (AFX) and mycosis fungoides (MF) has never been reported.
  • The pathologic specimen revealed a relatively well-circumscribed neoplasm in the upper dermis composed of atypical spindle cells with pleomorphism, hyperchromatic nuclei, and brisk mitotic activity.
  • Perilesional skin revealed epidermal hyperplasia, parakeratosis, and multiple epidermotropic lymphocytes with enlarged and hyperchromatic nuclei.
  • This neoplasm underwent a fusiform excision with clear margins.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Mycosis Fungoides / pathology. Skin Neoplasms / pathology

  • Genetic Alliance. consumer health - Mycosis fungoides.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18484429.001).
  • [ISSN] 0954-6634
  • [Journal-full-title] The Journal of dermatological treatment
  • [ISO-abbreviation] J Dermatolog Treat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


46. Hiscutt EL, Adams JR, Ryan JM, Langtry JA, Natarajan S: Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. Br J Oral Maxillofac Surg; 2009 Mar;47(2):157-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts.
  • We report the first case of atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma that developed in the site of a thermal burn that had previously been treated with multiple skin grafts.There is a controversy over the question of an increased risk of skin cancer in scars from burns and the various factors which may contribute to this.
  • [MeSH-major] Burns / complications. Carcinoma, Squamous Cell / etiology. Histiocytoma, Benign Fibrous / etiology. Melanoma / etiology. Skin Neoplasms / etiology
  • [MeSH-minor] Cicatrix / complications. Head and Neck Neoplasms / etiology. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged. Neck. Neoplasms, Multiple Primary / etiology. Neoplasms, Multiple Primary / surgery. Skin Transplantation


47. Gleason BC, Calder KB, Cibull TL, Thomas AB, Billings SD, Morgan MB, Hiatt KM, Smoller BR: Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma. J Cutan Pathol; 2009 May;36(5):543-7
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma.
  • Atypical fibroxanthoma (AFX), spindle cell squamous cell carcinoma (SCSCC) and spindle cell melanoma are the primary entities in the differential diagnosis of a cytologically atypical spindle cell tumor arising on sun-damaged skin.
  • AFX is generally regarded as a diagnosis of exclusion in this context: in the absence of S100 or keratin reactivity, a diagnosis of AFX is favored.
  • We evaluated 20 AFX and 10 SCSCC with a panel of cytokeratins and p63 to assess the utility of the latter antibody in this differential diagnosis.
  • Two additional cases (excluded from the study) were negative for keratins and S100 on initial shave biopsies, resulting in a favored diagnosis of AFX, but p63 stains performed retrospectively were positive.
  • However, review of the excision specimens in both cases revealed deep subcutaneous extension, excluding AFX. p63 reactivity argues against the diagnosis of AFX and is therefore a useful addition to the standard immunohistochemical panel for cutaneous spindle cell neoplasms.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Membrane Proteins / metabolism. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. S100 Proteins / biosynthesis

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Cutan Pathol. 2010 Oct;37(10):1123-4 [20175827.001]
  • (PMID = 19476522.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / S100 Proteins; 68238-35-7 / Keratins
  •  go-up   go-down


48. Hsu KF, Lin YS, Hsieh CB, Yu JC, Duh QY, Sheu LF, Jen YM, Shih ML: Primary malignant fibrous histiocytoma of the thyroid: review of the literature with two new cases. Thyroid; 2008 Jan;18(1):51-5
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary malignant fibrous histiocytoma of the thyroid: review of the literature with two new cases.
  • Primary malignant fibrous histiocytoma of thyroid is extremely rare.
  • Fine-needle aspiration cytology showed suspicious atypical cells.
  • Final pathology showed malignant fibrous histiocytoma.
  • A diagnostic lobectomy and pathology showed malignant fibrous histiocytoma.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / diagnosis. Thyroid Neoplasms / diagnosis

  • Genetic Alliance. consumer health - Malignant fibrous histiocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18302518.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
  •  go-up   go-down


49. Patton A, Page R, Googe PB, King R: Myxoid atypical fibroxanthoma: a previously undescribed variant. J Cutan Pathol; 2009 Nov;36(11):1177-84
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myxoid atypical fibroxanthoma: a previously undescribed variant.
  • BACKGROUND: Atypical fibroxanthomas (AFX) are dermal-based cutaneous tumors typically found in sun-damaged skin of the elderly.
  • Histologically all tumors demonstrated a well-circumscribed, cellular lesion centered in the dermis and composed of a mix of atypical pleomorphic and spindle cells in a prominent myxomatous background.
  • Myxoid change may be a prominent finding in benign and malignant cutaneous tumors and awareness of this variant of AFX will avoid misdiagnosis.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19320792.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


50. New D, Bahrami S, Malone J, Callen JP: Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature. Arch Dermatol; 2010 Dec;146(12):1399-404
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature.
  • BACKGROUND: Atypical fibroxanthoma (AFX) is a low-grade sarcoma usually occurring on sun-damaged skin of the head and neck in elderly patients.
  • Our patient was an 87-year-old man with a 7-week history of a rapidly growing AFX presenting as a 1.5-cm sessile nodule on his right mandible.
  • CONCLUSIONS: Atypical fibroxanthoma is a diagnosis of exclusion, and only a small number of metastatic AFX cases have been reported.
  • [MeSH-major] Histiocytoma, Benign Fibrous / secondary. Lymph Nodes / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biopsy. Diagnosis, Differential. Humans. Lymphatic Metastasis. Male. Neck

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20713774.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


51. Kemmerling R, Dietze O, Müller S, Neureiter D: Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma. Pathol Res Pract; 2009;205(5):365-70
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma.
  • We present a clear-cell atypical fibroxanthoma (CCAFX) and describe the morphological and immunohistochemical aspects of this rare skin lesion.
  • Furthermore, we give an overview of the differential diagnoses of clear-cell lesions of the skin for a practical approach.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Nose / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19155147.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


52. Ferri E, Iaderosa GA, Armato E: Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy. Auris Nasus Larynx; 2008 Jun;35(2):260-3
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy.
  • Atypical fibroxanthoma (AF) is an unusual cutaneous fibrohistiocytic tumour that is most commonly found in ENT sun-exposed areas of elderly males.
  • Cardiac transplant patients have an increased incidence of multiple cutaneous neoplasms, but the AF is uncommon.
  • Although this neoplasm is benign, it may mimic spindle cell carcinoma, squamous cell carcinoma, melanoma and soft tissue sarcoma on histologic examination.
  • Immunohistochemical stains for cytokeratin, alpha-1-antichymotrypsin, S100 protein and vimentin may be helpful in differential diagnosis.
  • We present a case of a cardiac transplant recipient who developed, after multiple cutaneous squamous tumours, an AF of external ear following the prolonged immunosuppressive treatment with cyclosporin.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Heart Transplantation. Histiocytoma, Benign Fibrous / pathology
  • [MeSH-minor] Aged. Cyclosporins. Diagnosis, Differential. Humans. Immunosuppressive Agents / adverse effects. Male. Postoperative Complications

  • MedlinePlus Health Information. consumer health - Heart Transplantation.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17804184.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclosporins; 0 / Immunosuppressive Agents
  •  go-up   go-down


53. de Feraudy S, Mar N, McCalmont TH: Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma and dermatofibroma. Am J Surg Pathol; 2008 Aug;32(8):1111-22
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma and dermatofibroma.
  • Atypical fibroxanthoma (AFX) (dermal pleomorphic sarcoma) remains a somewhat controversial entity.
  • In addition, the immunoperoxidase confirmation of AFX has been less than straightforward and has historically been approached as a diagnosis of exclusion because of the lack of sensitivity and specificity of available "positive" reagents.
  • Group 1 consisted of a retrospective review of 98 consecutive cases in which PC1 was used in the evaluation of dermatopathology specimens in routine practice during a 13-month interval.
  • Group 2 consisted of a direct comparison of 11 AFX, 11 dermatofibroma (DF), and 7 epithelioid dermatofibroma (EDF) using the CD10 reagent on cases identified by database search.
  • Group 3 consisted of a retrospective review of 47 cases in which CD10 was used in routine practice during a 10-month interval.
  • We believe that CD10 and PC1 immunostaining can be used as a useful adjunct to supplement the diagnosis of AFX, within the context of an immunoperoxidase panel.
  • [MeSH-major] Collagen Type I / analysis. Histiocytoma, Benign Fibrous / pathology. Neprilysin / analysis. Procollagen / analysis. Sarcoma / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / immunology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / immunology. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Epithelioid Cells / chemistry. Epithelioid Cells / immunology. Epithelioid Cells / pathology. Female. Humans. Immunohistochemistry / methods. Keratins / analysis. Male. Melanoma / chemistry. Melanoma / immunology. Melanoma / pathology. Middle Aged. Predictive Value of Tests. Reproducibility of Results. Retrospective Studies. S100 Proteins / analysis

  • Genetic Alliance. consumer health - Dermatofibroma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18545147.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Procollagen; 0 / S100 Proteins; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


54. Ang GC, Roenigk RK, Otley CC, Kim Phillips P, Weaver AL: More than 2 decades of treating atypical fibroxanthoma at mayo clinic: what have we learned from 91 patients? Dermatol Surg; 2009 May;35(5):765-72
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] More than 2 decades of treating atypical fibroxanthoma at mayo clinic: what have we learned from 91 patients?
  • BACKGROUND: Atypical fibroxanthoma (AFX) typically occurs on the head and neck of elderly white men.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Hospitals, University. Mohs Surgery / methods. Skin Neoplasms / surgery. Xanthomatosis / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Minnesota / epidemiology. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Time Factors. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19389106.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


55. Beer TW, Drury P, Heenan PJ: Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases. Am J Dermatopathol; 2010 Aug;32(6):533-40
Faculty of 1000. commentaries/discussion - See the articles recommended by F1000Prime's Faculty of more than 8,000 leading experts in Biology and Medicine. (subscription/membership/fee required).

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases.
  • The clinical and histological features of 171 atypical fibroxanthomas (AFX) from a single institution in Western Australia are outlined.
  • In conclusion, AFX may show a wide range of histological appearances, and a panel of immunohistochemical markers is essential to make the correct diagnosis.
  • Specific diagnosis is important because there seems to be a very low risk of recurrence or metastasis despite the frequently alarming histology.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20526171.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor
  •  go-up   go-down


56. Clarke LE, Frauenhoffer E, Fox E, Neves R, Bruggeman RD, Helm KF: CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma. J Cutan Pathol; 2010 Jul;37(7):737-43
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma.
  • CD10 is now commonly used to differentiate atypical fibroxanthoma (AFX) from melanoma, spindle cell and dedifferentiated variants of squamous cell carcinoma and leiomyosarcoma.
  • The purpose of this study was to evaluate CD10 expression in a wide range of mesenchymal neoplasms that may involve the skin using tissue microarrays.
  • Myxofibrosarcomas commonly present in the skin and may be difficult to distinguish from AFX on small biopsies and CD10 positivity may confound the diagnostic difficulty.
  • [MeSH-major] Fibrosarcoma / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Neprilysin / biosynthesis. Skin Neoplasms / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Tissue Array Analysis

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20175824.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


57. Beer TW, Haig D: CD117 is not a useful marker for diagnosing atypical fibroxanthoma. Am J Dermatopathol; 2009 Oct;31(7):649-52
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD117 is not a useful marker for diagnosing atypical fibroxanthoma.
  • Atypical fibroxanthoma (AFX) is a rare skin tumor that generally pursues an indolent course despite its alarming histological appearances.
  • It is important for the pathologist to distinguish this neoplasm from more aggressive lesions that may show very similar histological features.
  • [MeSH-major] Biomarkers, Tumor / analysis. Histiocytoma, Benign Fibrous / diagnosis. Proto-Oncogene Proteins c-kit / biosynthesis. Skin Neoplasms / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Am J Dermatopathol. 2010 Jul;32(5):528 [20526172.001]
  • (PMID = 19652583.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  •  go-up   go-down


58. Weinreb I, Rubin BP, Goldblum JR: Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement. J Cutan Pathol; 2008 Sep;35(9):855-60
Genetic Alliance. consumer health - Histiocytoma, angiomatoid fibrous.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement.
  • Angiomatoid fibrous histiocytoma (AFH) is a neoplasm of uncertain histogenesis with intermediate malignant potential.
  • It occurs in superficial soft tissues in any age group and at any body site, although the typical example occurs on extremities in children/young adults.
  • The neoplasm is usually composed of a bland histiocytoid proliferation of cells with eosinophilic cytoplasm forming a syncytium, often surrounded by a dense fibrous pseudocapsule and lymphoid infiltrate, with abundant intralesional hemorrhage forming blood-filled spaces.
  • AFH may show striking pleomorphism and mitotic activity, and such cases can lead to confusion with other atypical mesenchymal lesions, including pleomorphic sarcomas.
  • We present a diagnostically challenging case of AFH with pleomorphic features and minimal lymphoid and angiomatoid changes involving the superficial subcutis and deep dermis on the scalp of an 8-year-old boy.
  • "Areas with typical AFH morphology were identified and the diagnosis confirmed with identification of an EWSR1..." rearrangement detected by fluorescence in situ hybridization.
  • Pleomorphic AFH should be included in the differential diagnosis of atypical mesenchymal tumors of skin and superficial subcutis and molecular testing may prove helpful in this regard.
  • [MeSH-major] Histiocytoma, Malignant Fibrous / pathology. Oncogene Proteins, Fusion / genetics. Soft Tissue Neoplasms / pathology. Transcription Factors / genetics
  • [MeSH-minor] Child. DNA, Neoplasm / analysis. Gene Rearrangement. Humans. In Situ Hybridization, Fluorescence. Male. Neoplasm Recurrence, Local. RNA-Binding Protein FUS / genetics. RNA-Binding Protein FUS / metabolism. Scalp

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18422688.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / EWS-ATF1 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Protein FUS; 0 / Transcription Factors
  •  go-up   go-down


59. Gleason BC, Fletcher CD: Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol; 2008 Mar;32(3):354-62
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.
  • Benign fibrous histiocytoma (FH) is one of the most common mesenchymal neoplasms of the skin.
  • Several histologic variants of cutaneous FH have been described, some of which also have distinct clinical features including a propensity for local recurrence.
  • Four cases were classified as atypical deep FH due to the presence of scattered markedly pleomorphic spindle cells within an otherwise histologically typical lesion.
  • In summary, deep FH has many histologic features in common with cutaneous cellular FH; however, it usually has a more diffusely storiform pattern than the latter, is well circumscribed, and may have striking hemangiopericytomalike vessels.
  • Similar to the cellular, aneurysmal, and atypical variants of FH, deep FH recurs in approximately 20% of cases and may rarely metastasize.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Neoplasm Metastasis / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Actins / analysis. Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / analysis. Child. Desmin / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mitosis. Necrosis. Neoplasm Recurrence, Local

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18300816.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / Desmin
  •  go-up   go-down


60. Kanner WA, Brill LB 2nd, Patterson JW, Wick MR: CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. J Cutan Pathol; 2010 Jul;37(7):744-50
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma.
  • BACKGROUND: Atypical fibroxanthoma (AFX) is a pleomorphic spindle cell lesion of the skin; it is considered in the differential diagnosis with spindle cell malignant melanoma (MM) and sarcomatoid carcinoma/spindle cell squamous cell carcinoma (SCC).
  • CD10 positivity was preferentially associated with the diagnosis of AFX (p < 0.001).
  • CONCLUSION: CD10 positivity is relatively specific in this context for the diagnosis of AFX.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, CD / biosynthesis. Cell Adhesion Molecules / biosynthesis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Membrane Proteins / biosynthesis. Middle Aged. Neprilysin / biosynthesis

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • MedlinePlus Health Information. consumer health - Melanoma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20184665.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / CKAP4 protein, human; 0 / Cell Adhesion Molecules; 0 / Membrane Proteins; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


61. Farley R, Ratner D: Diagnosis and management of atypical fibroxanthoma. Skinmed; 2006 Mar-Apr;5(2):83-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis and management of atypical fibroxanthoma.
  • What is your diagnosis?
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Scalp. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16603840.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
  •  go-up   go-down


62. Sanatkumar S, Rajagopalan N, Mallikarjunaswamy B, Srinivasalu S, Sudhir NP, Usha K: Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: a case report. J Orthop Surg (Hong Kong); 2005 Apr;13(1):83-7
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: a case report.
  • Benign fibrous histiocytoma is such a rare tumour that only a few cases have been reported in the literature.
  • Because of its unusual radiological appearance and atypical clinical course, the lesion was diagnosed as fibrous histiocytoma.
  • [MeSH-major] Amputation. Bone Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Neoplasm Recurrence, Local / surgery. Orthopedic Procedures / adverse effects

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15872408.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


63. Wang HY, Fan QH, Gong QX, Wang Z: [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):169-72
Genetic Alliance. consumer health - Hemangiopericytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic characteristics of hemangiopericytoma/solitary fibrous tumor with giant cells].
  • OBJECTIVE: To study the pathological characteristics, diagnosis and differential diagnoses of hemangiopericytoma-solitary fibrous tumor with giant cells.
  • METHODS: Pathological characteristics of seven cases of orbital and extraorbital hemangiopericytoma-solitary fibrous tumors with giant cells were evaluated by HE and immunohistochemistry (EnVision method).
  • Histologically, the tumors were well-circumscribed and composed of non-atypical, round to spindle cells with collagen deposition in the stroma.
  • CONCLUSIONS: Hemangiopericytoma-solitary fibrous tumor with giant cells is an intermediate soft tissue tumor.
  • Histologically, the tumor should be distinguished from giant cell fibroblastoma, pleomorphic hyalinzing angiectatic tumor of soft part and angiomatoid fibrous histiocytoma.
  • [MeSH-major] Hemangiopericytoma / pathology. Orbital Neoplasms / pathology. Solitary Fibrous Tumors / pathology
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Cell Adhesion Molecules / metabolism. Dermatofibrosarcoma / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Histiocytoma, Benign Fibrous / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-bcl-2 / metabolism. Soft Tissue Neoplasms / pathology. Solitary Fibrous Tumor, Pleural / metabolism. Solitary Fibrous Tumor, Pleural / pathology. Solitary Fibrous Tumor, Pleural / surgery. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19575851.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Proto-Oncogene Proteins c-bcl-2
  •  go-up   go-down


64. Wen J, Wang XY, Luo CY, Jiang GS, Wang LJ, Chen YW: [Benign fibrous histiocytoma involving the skull: a case report and literature review]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Dec;30(12):2752-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign fibrous histiocytoma involving the skull: a case report and literature review].
  • OBJECTIVE: Benign fibrous histiocytomas (BFH) represent a rare group of tumors with a common origin from the tissue histiocytes, often causing pain and space-occupying effect.
  • BFH of bone causes diagnostic difficulties due to its atypical clinical symptoms, radiographic features and cytological characteristics, which can be easily confused with other benign lesions such as non-ossifying fibroma (NOF), giant cell tumor (GCT), and fibrous dysplasia.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skull / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21177160.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  •  go-up   go-down


65. Offman S, Pasternak S, Walsh N: Keloidal and other collagen patterns in atypical fibroxanthomas. Am J Dermatopathol; 2010 Jun;32(4):326-32
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Keloidal and other collagen patterns in atypical fibroxanthomas.
  • Collagen deposition is observed in several cutaneous neoplasms and its derivation is variable.
  • It can represent (1) a mesenchymal component of a biphasic tumor, (2) a desmoplastic host response to a neoplasm, or (3) a product of the tumor cells.
  • The result is that collagenous (desmoplastic) variants of many cutaneous neoplasms are well recognized.
  • In regard to atypical fibroxanthoma (AFX), conventional wisdom holds that intratumoral collagen is not commonly observed, apart from the rare sclerotic subtype of the neoplasm.
  • (1) Is the collagen part of a host response to the neoplasm or is it a product of the tumor cells?
  • The goal is to facilitate accuracy in diagnosis and to promote further investigation.
  • [MeSH-major] Collagen. Histiocytoma, Benign Fibrous / pathology. Keloid / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20514669.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
  •  go-up   go-down


66. Hügel H: [Fibrohistiocytic skin tumors]. J Dtsch Dermatol Ges; 2006 Jul;4(7):544-55
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Fibrohistiocytic skin tumors].
  • The fibrohistiocytic tumors of the skin are a heterogeneous group of dermal/subcutaneous mesenchymal neoplasms which show fibroblastic, myofibroblastic and histiocytic (macrophage-like) differentiation, often one beside the other in the same tumor.
  • "Fibrohistiocytic" means in this context the morphologic similarity of the cells with fibroblasts and histiocytes.
  • The WHO classification of 2005 includes the following entities as fibrohistiocytic tumors of the skin: BENIGN: 1.
  • Fibrous histiocytoma (FH)/(synonymous: Dermatofibroma.
  • Variants of FH: 1a. cellular fibrous histiocytoma, 1b. atypical (pseudosarcomatous) fibrous histiocytoma, 1c. aneurysmatic fibrous histiocytoma, 1d. epithelioid fibrous histiocytoma; 2. dermatomyofibroma; 3. (juvenile) xanthogranuloma.
  • INTERMEDIATE: 4. plexiform fibrohistiocytic tumor; 5. dermatofibrosarcoma protuberans; 6. atypical Fibroxanthoma.
  • MALIGNANT: 7. malignant fibrous histiocytoma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / classification. Histiocytoma, Benign Fibrous / pathology. Leiomyoma / classification. Leiomyoma / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Histiocytic Disorders, Malignant / classification. Histiocytic Disorders, Malignant / pathology. Humans

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16827912.001).
  • [ISSN] 1610-0379
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 53
  •  go-up   go-down


67. Amico P, Vecchio GM, Bisceglia M, Vasquez E, Magro G: Atypical dermatofibroma with predominant epithelioid/deciduoid-like cell component. Histogenetic considerations in the wide spectrum of fibrohistiocytic dermal tumours. Pathologica; 2010 Jun;102(3):115-8
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical dermatofibroma with predominant epithelioid/deciduoid-like cell component. Histogenetic considerations in the wide spectrum of fibrohistiocytic dermal tumours.
  • Atypical and epithelioid cell variants of dermatofibroma may represent a potential diagnostic pitfall.
  • Only rarely atypical dermatofibroma may show focal epithelioid cell features.
  • We herein report a rare case of dermatofibroma composed of a predominant (> 90%) epithelioid/deciduoid-like cell component, in which rare multinucleated bizarre cells and atypical mitoses were additional findings.
  • Tumour was classified as "atypical dermatofibroma with predominant epithelioid/deciduoid-like cell component".
  • The coexistence of at least two different variants, i.e. epithelioid and atypical variants, in the same dermatofibroma suggests that dermal fibrohistiocytic tumours belong to a continuous morphological spectrum.
  • Differential diagnosis with other epitheliod cell dermal tumour- and tumour-like lesions is discussed.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Histiocytoma, Malignant Fibrous / pathology. Skin Neoplasms / pathology

  • Genetic Alliance. consumer health - Dermatofibroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21171517.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


68. Mertz KD, Mentzel T, Grob M, Pfaltz M, Kempf W: A rare case of atypical cellular neurothekeoma in a 68-year-old woman. J Cutan Pathol; 2009 Nov;36(11):1210-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of atypical cellular neurothekeoma in a 68-year-old woman.
  • The atypical variant of cellular neurothekeoma, characterized by features such as large size, deep penetration, diffusely infiltrative borders, vascular invasion, high mitotic rate and marked cytologic pleomorphism, has been very rarely reported in the literature.
  • We present the clinical, histopathological and immunohistochemical profile of a new case of atypical cellular neurothekeoma in a 68-year-old female patient who was diagnosed with ductal breast carcinoma in situ before.
  • An erythematous painless papule arose in her right breast, and tentative clinical diagnosis was orientated toward skin metastasis of breast cancer or fibroma.
  • Upon histological examination, the lesion showed the histological and immunohistochemical features of atypical variant of cellular neurothekeoma with high mitotic rate, marked cellular pleomorphism and penetration into subcutaneous fat.
  • A further unusual feature in our patient was her age, because she is the oldest patient reported in the literature with diagnosis of atypical cellular neurothekeoma so far.
  • Prognosis remains uncertain because only few cases of atypical cellular neurothekeoma have been reported in the literature, with a very limited follow-up time.
  • Our report contributes to a better characterization of the clinical and morphologic features of atypical cellular neurothekeoma.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neurothekeoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / pathology. Humans. Immunohistochemistry. Microscopy, Electron, Scanning

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19469878.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


69. Kovach BT, Sams HH, Stasko T: Multiple atypical fibroxanthomas in a cardiac transplant recipient. Dermatol Surg; 2005 Apr;31(4):467-70
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple atypical fibroxanthomas in a cardiac transplant recipient.
  • BACKGROUND: Solid organ transplant recipients have an increased incidence of multiple cutaneous neoplasms.
  • OBJECTIVE: We hope to draw attention to the potential risk for organ transplant recipients to develop atypical fibroxanthomas.
  • RESULTS: We present the case of a cardiac transplant recipient who developed three atypical fibroxanthomas.
  • This is the first reported case of multiple atypical fibroxanthomas in an organ transplant recipient.
  • CONCLUSION: Atypical fibroxanthomas are uncommon cutaneous malignancies for which transplant recipients may be at increased risk.
  • [MeSH-major] Heart Transplantation. Histiocytoma, Benign Fibrous / surgery. Neoplasms, Multiple Primary / surgery. Postoperative Complications / surgery. Skin Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - After Surgery.
  • MedlinePlus Health Information. consumer health - Heart Transplantation.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15871326.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


70. Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M: High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors. Arch Pathol Lab Med; 2006 Jun;130(6):831-4
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors.
  • CONTEXT: Dermatofibroma is a benign fibrohistiocytic tumor composed of a mixture of fibroblastic and histiocytic cells.
  • The diagnosis of this tumor is generally uncomplicated; however, rare variants may be difficult to distinguish from malignant fibrohistiocytic tumors.
  • Deep penetrating dermatofibroma may be difficult to distinguish from dermatofibrosarcoma protuberans, and pseudosarcomatous dermatofibroma and dermatofibroma with monster giant cells share morphologic similarities with malignant fibrous histiocytoma and atypical fibroxanthoma.
  • OBJECTIVE: To find an immunohistochemical marker or markers that differentiate between fibrohistiocytic lesions of skin.
  • DESIGN: We evaluated the immunophenotypic characteristics of 83 fibrohistiocytic tumors (36 typical dermatofibromas, 16 cases of dermatofibrosarcoma protuberans, 16 malignant fibrous histiocytomas, and 15 atypical fibroxanthomas) using antibodies against MIB-1 (Ki-67), factor XIIIa, CD34 (HPCA-1), HHF35 (muscle-specific actin), 1A4 (smooth muscle actin), cytokeratin (AE1/AE3, CAM 5.2, and 34betaE12), S100 protein, and desmin.
  • RESULTS: A high proliferative index detected by MIB-1 staining excluded the possibility of dermatofibroma and was diagnostically useful in separating this entity from dermatofibrosarcoma protuberans, malignant fibrous histiocytoma, and atypical fibroxanthoma.
  • Factor XIIIa reactivity was not helpful for the diagnosis of dermatofibroma, whereas CD34 reactivity was statistically significant in the diagnosis of dermatofibrosarcoma protuberans.
  • CONCLUSION: Evaluation of the proliferative index may further assist in distinguishing dermatofibroma from dermatofibrosarcoma protuberans, atypical fibroxanthoma, and malignant fibrous histiocytoma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Ki-67 Antigen / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Biopsy. Cell Nucleus / metabolism. Cell Nucleus / pathology. Cell Proliferation. Dermatofibrosarcoma / pathology. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Histiocytoma, Malignant Fibrous / pathology. Humans. Immunoenzyme Techniques. Xanthomatosis / pathology

  • Genetic Alliance. consumer health - Dermatofibroma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Arch Pathol Lab Med. 2008 Feb;132(2):160; author reply 160-1 [18251566.001]
  • (PMID = 16740036.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
  •  go-up   go-down


71. Lisovsky M, Hoang MP, Dresser KA, Kapur P, Bhawan J, Mahalingam M: Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. Mod Pathol; 2008 Jan;21(1):31-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans.
  • To corroborate these results, we sought to ascertain the utility of Apo D by investigating its sensitivity and specificity in a variety of CD34-positive and CD34-negative cutaneous neoplasms including superficial acral fibromyxoma, sclerotic fibromas, and cellular dermatofibromas.
  • Of interest, we found absence of Apo D expression in all four cases of superficial acral fibromyxoma.
  • Of the remaining CD34-positive lesions, Apo D expression was noted in 35/36 (97%) cases of dermatofibrosarcoma protuberans, 3/5 (60%) giant-cell fibroblastomas, 4/4 (100%) sclerotic fibromas, 8/8 (100%) neurofibromas, and 1/1 (100%) solitary fibrous tumor.
  • Of the CD34-negative lesions, Apo D expression was noted in 2/22 (9%) regular dermatofibroma, 23/45 (51%) cellular dermatofibroma, 10/10 (100%) malignant fibrous histiocytoma, 9/10 (90%) atypical fibroxanthoma, 7/8 (86%) cellular neurothekeoma, 9/9 (100%) malignant melanoma, 8/8 (100%) melanocytic nevi (100%), 0/2 superficial angiomyxoma, 0/15 fibromatosis, 0/1 nodular fasciitis, and 1/2 (50%) desmoplastic fibroblastomas.
  • Its principal use as an immunohistochemical adjunct lies in its utility in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans.
  • Although strong positive staining of Apo D in a markedly atypical fibrohistiocytic lesion is suggestive of atypical fibroxanthoma and/or malignant fibrous histiocytoma, further studies with the inclusion of other atypical spindled cell neoplasms are required to conclusively prove the same.
  • [MeSH-major] Antigens, CD34 / analysis. Apolipoproteins D / analysis. Biomarkers, Tumor / analysis. Dermatofibrosarcoma / diagnosis. Fibroma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Giant Cell Tumors / chemistry. Giant Cell Tumors / diagnosis. Giant Cell Tumors / immunology. Histiocytoma, Benign Fibrous / chemistry. Histiocytoma, Benign Fibrous / diagnosis. Histiocytoma, Benign Fibrous / immunology. Humans. Immunohistochemistry. Melanoma / chemistry. Melanoma / diagnosis. Melanoma / immunology. Nevus, Pigmented / chemistry. Nevus, Pigmented / diagnosis. Nevus, Pigmented / immunology. Reproducibility of Results. United States

  • Genetic Alliance. consumer health - Dermatofibrosarcoma Protuberans.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17885669.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Apolipoproteins D; 0 / Biomarkers, Tumor
  •  go-up   go-down


72. Sachdev R, Robbins J, Kohler S, Vanchinathan V, Schwartz EJ, Sundram UN: CD163 expression is present in cutaneous histiocytomas but not in atypical fibroxanthomas. Am J Clin Pathol; 2010 Jun;133(6):915-21
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD163 expression is present in cutaneous histiocytomas but not in atypical fibroxanthomas.
  • Our aim was to test the ability of CD163 to separate cutaneous histiocytomas from their morphologic mimics.
  • We tested the expression of CD163 in 78 cases, including 19 xanthogranulomas, 16 atypical fibroxanthomas, 6 reticulohistiocytomas, 8 epithelioid cell histiocytomas, 9 cases of Langerhans cell histiocytosis, 10 xanthomas, and 10 intradermal Spitz nevi.
  • CD163 expression was seen in all xanthogranulomas and reticulohistiocytomas, 4 epithelioid cell histiocytomas, 2 cases of Langerhans cell histiocytosis, and 8 xanthomas but was absent in atypical fibroxanthomas and Spitz nevi.
  • CD163 is an excellent marker for confirming histiocytic differentiation and is useful in eliminating morphologic mimics such as Spitz nevi from the differential diagnosis.
  • The lack of CD163 in atypical fibroxanthomas argues against a histiocytic origin for this tumor.
  • [MeSH-major] Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Biomarkers, Tumor / immunology. Histiocytoma, Benign Fibrous / chemistry. Histiocytoma, Benign Fibrous / immunology. Receptors, Cell Surface / analysis. Skin Neoplasms / immunology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20472850.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD163 antigen; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Receptors, Cell Surface; 0 / Receptors, Scavenger; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


73. Rieske P, Zakrzewska M, Biernat W, Bartkowiak J, Zimmermann A, Liberski PP: Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome. J Neurooncol; 2005 Jan;71(1):27-30
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical molecular background of glioblastoma and meningioma developed in a patient with Li-Fraumeni syndrome.
  • We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome.
  • [MeSH-major] Germ-Line Mutation. Glioblastoma / genetics. Histiocytoma, Benign Fibrous / genetics. Li-Fraumeni Syndrome / genetics. Meningioma / genetics. Neoplasms, Multiple Primary / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Brain Neoplasms / genetics. Brain Neoplasms / therapy. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 22 / genetics. DNA / analysis. Fatal Outcome. Genetic Testing. Humans. Loss of Heterozygosity. Male. Microsatellite Repeats. Skin Neoplasms / genetics. Skin Neoplasms / therapy


74. Orrock JM, Abbott JJ, Gibson LE, Folpe AL: INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics. Am J Dermatopathol; 2009 Apr;31(2):152-6
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics.
  • The morphological features of epithelioid sarcoma may closely mimic those of epithelial neoplasms, such as squamous cell carcinoma, mesenchymal tumors, such as benign fibrous histiocytoma, and nonneoplastic lesions, such as granuloma annulare.
  • Immunohistochemistry, particularly for epithelial markers and CD34, thus plays a valuable role in the differential diagnosis of epithelioid sarcoma.
  • We examined the utility of immunohistochemistry for INI1 and GLUT-1 in the diagnosis of epithelioid sarcoma and various cutaneous mimics.
  • Twenty-four cases of epithelioid sarcoma, 13 cases of granuloma annulare, 10 cases of rheumatoid nodule, 19 cases of cutaneous squamous cell carcinoma, 7 cases of atypical fibroxanthoma, 9 cases of benign fibrous histiocytoma (dermatofibroma), and 3 cases of nodular fasciitis were immunostained for GLUT-1 and INI1 using commercially available antibodies, heat-induced epitope retrieval, and the Dako Envision detection system.
  • GLUT-1 was positive in 40%-50% of epithelioid sarcomas, all cases of granuloma annulare and rheumatoid nodules, 67% of benign fibrous histiocytomas, and in all squamous cell carcinomas.
  • In contrast, atypical fibroxanthomas and cases of nodular fasciitis were consistently GLUT-1 negative.
  • We conclude that immunohistochemistry for INI1 expression should be included as part of the routine immunohistochemical panel for the diagnosis of epithelioid sarcoma, along with established markers such as wide-spectrum cytokeratins, cytokeratin 5/6, p63, and CD34.
  • In this clinical context, loss of INI1 expression seems to be an entirely specific marker of epithelioid sarcoma and this finding may be of great value in distinguishing CD34-negative epithelioid sarcoma from squamous cell carcinoma and in the distinction of rare cytokeratin-negative epithelioid sarcomas from necrobiotic processes, nodular fasciitis, and benign fibrous histiocytomas.
  • In contrast, there does not seem to be a role for GLUT-1 immunohistochemistry in this differential diagnosis.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / metabolism. DNA-Binding Proteins / metabolism. Glucose Transporter Type 1 / metabolism. Granuloma Annulare / metabolism. Sarcoma / metabolism. Skin Diseases / metabolism. Skin Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Biomarkers / metabolism. Diagnosis, Differential. Fasciitis / metabolism. Fasciitis / pathology. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Humans. Neoplasms, Squamous Cell / metabolism. Neoplasms, Squamous Cell / pathology. Rheumatoid Nodule / metabolism. Rheumatoid Nodule / pathology. Xanthomatosis / metabolism. Xanthomatosis / pathology

  • Genetic Alliance. consumer health - Epithelioid Sarcoma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • MedlinePlus Health Information. consumer health - Skin Conditions.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19318800.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Glucose Transporter Type 1; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  •  go-up   go-down


75. Choi YJ, Kim KW, Cha EY, Song JS, Yu E, Lee MG: Case report. Sclerosing liver haemangioma with pericapillary smooth muscle proliferation: atypical CT and MR findings with pathological correlation. Br J Radiol; 2008 Jun;81(966):e162-5
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report. Sclerosing liver haemangioma with pericapillary smooth muscle proliferation: atypical CT and MR findings with pathological correlation.
  • Because the tumour showed atypical features on CT and MRI, a correct diagnosis could not be made until surgery.
  • In this report, the atypical radiological findings are illustrated and correlated with pathological findings.
  • [MeSH-major] Histiocytoma, Benign Fibrous / diagnosis. Liver Neoplasms / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18487382.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


76. Ríos-Martín JJ, Delgado MD, Moreno-Ramírez D, García-Escudero A, González-Cámpora R: Granular cell atypical fibroxanthoma: report of two cases. Am J Dermatopathol; 2007 Feb;29(1):84-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell atypical fibroxanthoma: report of two cases.
  • Two cases of an uncommon histopathological variant of atypical fibroxanthoma (AFX) are described.
  • Even though both lesions presented as clinically conventional atypical fibroxanthoma, histopathology disclosed a neoplasm composed of cells with granular change that was negative for S100 staining, and showed prominent pleomorphism, severe nuclear atypia, and a high mitotic index.
  • The differential diagnosis with primitive nonneural granular cell tumor is discussed.
  • [MeSH-major] Fibroma / pathology. Granular Cell Tumor / pathology. Skin Neoplasms / pathology. Xanthomatosis / pathology
  • [MeSH-minor] Aged, 80 and over. Cell Proliferation. Diagnosis, Differential. Humans. Male. Phenotype. S100 Proteins / metabolism

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17284969.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
  •  go-up   go-down


77. Andres C, Puchta U, Flaig MJ: Detection of Merkel cell polyomavirus DNA in atypical fibroxanthoma in correlation to clinical features. Am J Dermatopathol; 2010 Dec;32(8):799-803
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of Merkel cell polyomavirus DNA in atypical fibroxanthoma in correlation to clinical features.
  • A clear etiopathogenetic concept for atypical fibroxanthoma (AFX) is not established yet.
  • Nevertheless, AFX is known as a pleomorphic but indolent tumor primarily of the elderly and/or immunosuppressed patient occurring in severely sun- or radiation-damaged skin.
  • These risk factors are almost identical to those of Merkel cell carcinoma (MCC), a highly malignant skin tumor being thought to be pathogenetically associated with the recently discovered Merkel cell polyomavirus (MCPyV).
  • [MeSH-major] Carcinoma, Merkel Cell / virology. DNA, Viral / isolation & purification. Merkel Cells / virology. Polyomavirus / isolation & purification. Polyomavirus Infections / virology. Skin Diseases / virology. Skin Neoplasms / virology. Tumor Virus Infections / virology. Xanthomatosis / virology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20861707.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  •  go-up   go-down


78. Lee JC, Christensen T, O'Hara CJ: Metastatic interdigitating dendritic cell sarcoma masquerading as a skin primary tumor: a case report and review of the literature. Am J Dermatopathol; 2009 Feb;31(1):88-93
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic interdigitating dendritic cell sarcoma masquerading as a skin primary tumor: a case report and review of the literature.
  • We report an unusual case of a lymph node interdigitating dendritic cell sarcoma (IDCS), metastatic to skin, in a 73-year-old patient.
  • The patient initially presented as having a primary skin tumor with lymph node metastasis.
  • The metastatic IDCS was initially read as an atypical fibroxanthoma.
  • Additional immunohistochemistry was performed on the shave biopsy, confirming that the skin tumor was a metastasis.
  • In the workup of a spindle cell neoplasm, IDCS should be included in the differential diagnosis.
  • [MeSH-major] Dendritic Cell Sarcoma, Interdigitating / pathology. Lymph Nodes / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Histiocytoma, Benign Fibrous / pathology. Humans. Hyperlipidemias / complications. Hypertension / complications. Immunohistochemistry. Neoplasms, Second Primary / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19155734.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


79. Wollina U, Schönlebe J, Koch A, Haroske G: Atypical fibroxanthoma: a series of 25 cases. J Eur Acad Dermatol Venereol; 2010 Aug;24(8):943-6
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma: a series of 25 cases.
  • OBJECTIVE: Atypical fibroxanthoma is a rare mesenchymal tumour of skin that develops on skin of elderly patients.
  • We analysed our patients with atypical fibroxanthoma over the last 8 years.
  • [MeSH-major] Skin Neoplasms / diagnosis. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Cheek. Female. Follow-Up Studies. Forehead. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Retrospective Studies. Scalp. Treatment Outcome. Vimentin / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20158588.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Vimentin
  •  go-up   go-down


80. Paramanathan N, Gal A, Benger R: Paraffin histology sections and delayed repair in recurrent atypical fibroxanthoma of the eyelid. Orbit; 2009;28(6):380-2
MedlinePlus Health Information. consumer health - Eyelid Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraffin histology sections and delayed repair in recurrent atypical fibroxanthoma of the eyelid.
  • We present a report of a recurrent atypical fibroxanthoma (AFX), a tumour known rarely to involve the eyelid.
  • A 61 year-old male was referred after reappearance of a lower eyelid AFX within two months of resection.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19929664.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers; 0 / CD68 antigen, human
  •  go-up   go-down


81. Tronnier M, Vogelbruch M: Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31. J Cutan Pathol; 2007 Dec;34 Suppl 1:58-63
Genetic Alliance. consumer health - Syringocystadenoma papilliferum.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31.
  • The occurrence of an atypical fibroxanthoma in association with a syringocystadenoma papilliferum is reported.

  • Genetic Alliance. consumer health - Nevus.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17997741.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
  •  go-up   go-down


82. Khong JJ, Muecke J: Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol; 2006 Jul;90(7):819-22
Hazardous Substances Data Bank. MITOMYCIN C .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: One to three 7 day cycles of topical MMC 0.04% four times a day were given to 59 eyes with localised corneal-conjunctival intraepithelial neoplasia (CIN), 19 eyes with diffuse CIN, six eyes with recurrent CIN, one eye with ocular surface squamous cell carcinoma, three eyes with primary acquired melanosis (PAM) with atypia, nine eyes with conjunctival malignant melanoma (MM), two eyes with sebaceous carcinoma with pagetoid spread, and one eye with recurrent atypical fibroxanthoma.
  • 31 (34%) cases developed an allergic reaction to MMC and 14 (14%) eyes had epiphora secondary to punctal stenosis at a mean follow up period of 26.5 months.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / drug therapy. Carcinoma in Situ / drug therapy. Carcinoma, Squamous Cell / drug therapy. Conjunctival Neoplasms / drug therapy. Corneal Diseases / drug therapy. Female. Follow-Up Studies. Histiocytoma, Benign Fibrous / drug therapy. Humans. Lacrimal Apparatus Diseases / chemically induced. Lacrimal Duct Obstruction / chemically induced. Male. Melanoma / drug therapy. Melanosis / drug therapy. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Drug Reactions.
  • MedlinePlus Health Information. consumer health - Eye Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Arch Ophthalmol. 1996 Oct;114(10):1261-4 [8859090.001]
  • [Cites] Cornea. 1996 Sep;15(5):537-40 [8862932.001]
  • [Cites] Ophthalmology. 1997 Dec;104(12):2085-93 [9400769.001]
  • [Cites] Am J Ophthalmol. 1997 Sep;124(3):303-11 [9439356.001]
  • [Cites] Am J Ophthalmol. 1997 Sep;124(3):397-9 [9439368.001]
  • [Cites] Br J Ophthalmol. 1998 May;82(5):476-9 [9713051.001]
  • [Cites] Am J Ophthalmol. 2005 Aug;140(2):325-7 [16086962.001]
  • [Cites] Allergy. 1997 Jun;52(6):687 [9226075.001]
  • [Cites] Contact Dermatitis. 2000 Feb;42(2):74-6 [10703627.001]
  • [Cites] Arch Ophthalmol. 2000 Jul;118(7):885-91 [10900099.001]
  • [Cites] Ophthalmology. 2001 May;108(5):994-5 [11320034.001]
  • [Cites] Clin Experiment Ophthalmol. 2002 Apr;30(2):94-8 [11886411.001]
  • [Cites] Am J Ophthalmol. 2002 May;133(5):601-6 [11992855.001]
  • [Cites] Ophthal Plast Reconstr Surg. 2002 Jul;18(4):285-8 [12142762.001]
  • [Cites] Ophthalmology. 2002 Nov;109(11):2129-33 [12414427.001]
  • [Cites] Am J Ophthalmol. 2003 Aug;136(2):375-7 [12888073.001]
  • [Cites] Ophthal Plast Reconstr Surg. 2003 May;19(3):216-24 [12918558.001]
  • [Cites] Am J Ophthalmol. 2003 Oct;136(4):746-7 [14516822.001]
  • [Cites] Am J Ophthalmol. 2004 May;137(5):950-1 [15126170.001]
  • [Cites] Br J Ophthalmol. 2004 Nov;88(11):1422-4 [15489486.001]
  • [Cites] Br J Dermatol. 1990 Feb;122(2):217-24 [2138492.001]
  • [Cites] Ophthalmology. 1992 Nov;99(11):1647-54 [1454338.001]
  • [Cites] Am J Ophthalmol. 1994 Feb 15;117(2):164-8 [8116744.001]
  • [CommentIn] Br J Ophthalmol. 2006 Jul;90(7):807-9 [16782942.001]
  • (PMID = 16672325.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
  • [Other-IDs] NLM/ PMC1857172
  •  go-up   go-down


83. Eyden B: The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions. J Submicrosc Cytol Pathol; 2005 Nov;37(3-4):231-96
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrastructural features are described of nodular fasciitis, the myofibromatoses (including Dupuytren's disease), inflammatory myofibroblastic tumour, post-operative spindle cell nodule, fibroma of tendon sheath, fibrous pseudotumour, benign fibrous histiocytoma, atypical fibroxanthoma, dermatofibrosarcoma protuberans, myofibrosarcoma (myofibroblastic sarcoma), malignant fibrous histiocytoma (pleomorphic myofibrosarcoma), epithelioid sarcoma and spindle-cell carcinoma.
  • The fibronexus is emphasised as an important marker for the most confident diagnosis of myofibrosarcoma.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16612972.001).
  • [ISSN] 1122-9497
  • [Journal-full-title] Journal of submicroscopic cytology and pathology
  • [ISO-abbreviation] J. Submicrosc. Cytol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 344
  •  go-up   go-down


84. Shimada S, Ishizawa T, Ishizawa K, Matsumura T, Hasegawa T, Hirose T: The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers. Hum Pathol; 2006 Sep;37(9):1123-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers.
  • Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and dedifferentiated liposarcoma (DDL) are reported to have murine double-minute type 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) amplification as a characteristic genetic alteration.
  • To evaluate the diagnostic utility of this gene abnormality, we analyzed 19 liposarcomas, 21 malignant fibrous histiocytomas, 3 leiomyosarcomas, 5 malignant peripheral nerve sheath tumors, 23 lipomas, and 28 nonneoplastic fat tissues using real-time polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH).
  • In FISH, all ALT/WDLs and DDLs had both MDM2 and CDK4 amplifications, and all of the myxoid/round cell liposarcomas, leiomyosarcomas, malignant peripheral nerve sheath tumors, and all but one of the malignant fibrous histiocytomas did not have the amplifications.
  • An analysis of MDM2 and CDK4 amplification using real-time PCR, as well as FISH, is useful for the differential diagnosis of liposarcomas and their histologic mimickers.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Liposarcoma / diagnosis. Liposarcoma / genetics. Proto-Oncogene Proteins c-mdm2 / genetics
  • [MeSH-minor] Adipose Tissue / pathology. Adipose Tissue / physiology. Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Gene Amplification. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytoma, Malignant Fibrous / genetics. Humans. In Situ Hybridization, Fluorescence. Infant. Leiomyosarcoma / diagnosis. Leiomyosarcoma / genetics. Lipoma / diagnosis. Lipoma / genetics. Male. Middle Aged. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / genetics. Reverse Transcriptase Polymerase Chain Reaction

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16938516.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  •  go-up   go-down


85. Garrido-Ruiz MC, Carrillo R, Enguita AB, Peralto JL: Signet-ring cell dermatofibroma. Am J Dermatopathol; 2009 Feb;31(1):84-7
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dermatofibroma or cutaneous fibrous histiocytoma is a common benign skin lesion with multiple, distinct histologic variants, including cellular, aneurismal, epithelioid, atypical, lipidized "ankle-type," palisading, and cholesterotic.
  • Indeed, although extremely rarely, metastases have been associated with the cellular and aneurysmal/atypical variants.
  • The finding of signet-ring cells in a skin neoplasm always raises the suspicion of metastatic adenocarcinoma, although a number of reports have shown their occurrence in primitive cutaneous neoplasms as well.
  • We present, for the first time, a new, distinctive variant of dermatofibroma, so-called signet-ring cell dermatofibroma, in a 16-year-old man with a slowly growing skin tumor on the lateral side of his right leg.
  • Histologic examination demonstrated a striking signet-ring cell appearance of most of the cells in an otherwise fibrohistiocytic looking proliferation.
  • Histochemical and immunohistochemical stainings confirmed the diagnosis of dermatofibroma.
  • The phenomenon described in this case enlarges the histologic spectrum of cutaneous fibrous histiocytoma and may cause substantial differential diagnostic problems.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

  • Genetic Alliance. consumer health - Dermatofibroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19155733.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


86. Daigeler A, Lehnhardt M, Sebastian A, Belyaev O, Steinstraesser L, Steinau HU, Kuhnen C: Metachronous bilateral soft tissue sarcoma of the extremities. Langenbecks Arch Surg; 2008 Mar;393(2):207-12
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each.
  • In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account.
  • A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient.
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Female. Follow-Up Studies. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / surgery. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Lymphatic Metastasis. Male. Middle Aged. Mitotic Index. Necrosis. Neoplasm Staging. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Prognosis. Retrospective Studies. Sarcoma, Clear Cell / pathology. Sarcoma, Clear Cell / surgery. Young Adult

  • Genetic Alliance. consumer health - Soft tissue sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Clin Cancer Res. 2000 Jul;6(7):2788-93 [10914725.001]
  • [Cites] CA Cancer J Clin. 2004 Jan-Feb;54(1):8-29 [14974761.001]
  • [Cites] Br J Cancer. 1999 Oct;81(3):532-6 [10507781.001]
  • [Cites] Cancer. 2001 Apr 1;91(7):1363-71 [11283938.001]
  • [Cites] Anticancer Res. 2002 Jul-Aug;22(4):2409-12 [12174935.001]
  • [Cites] Br J Cancer. 1993 Dec;68(6):1243-6 [8260380.001]
  • [Cites] Science. 1990 Nov 30;250(4985):1233-8 [1978757.001]
  • [Cites] Cancer. 2004 Dec 1;101(11):2633-5 [15494976.001]
  • [Cites] Med Pediatr Oncol. 1998 Mar;30(3):165-9 [9434825.001]
  • [Cites] Arch Surg. 1992 Dec;127(12):1379-85 [1365680.001]
  • [Cites] Int J Cancer. 1996 Apr 10;66(2):176-8 [8603807.001]
  • [Cites] J Pediatr Surg. 1995 Jul;30(7):1042-4; discussion 1044-5 [7472929.001]
  • [Cites] J Pediatr Hematol Oncol. 1998 Sep-Oct;20(5):494-7 [9787328.001]
  • [Cites] Acta Chir Scand. 1988 Jul-Aug;154(7-8):477-9 [3188797.001]
  • [Cites] Skeletal Radiol. 1988;17 (7):518-21 [2849210.001]
  • (PMID = 17242894.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


87. Melendez MM, Xu X, McClain SA, Huang SI: Atypical fibroxanthoma in a young woman: An unusual case presentation. Can J Plast Surg; 2007;15(3):169-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical fibroxanthoma in a young woman: An unusual case presentation.
  • Atypical fibroxanthoma (AFX) is an uncommon neoplasm, identified as a spindle cell tumour that is generally found in elderly patients on sun-exposed areas.
  • The present case report highlights the importance of correct diagnosis for AFX with adequate excision and by considering the histopathology and immunohisto-chemistry of its clinical differential diagnosis.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Cutan Pathol. 2006 Apr;33(4):318-22 [16630185.001]
  • [Cites] J Cutan Pathol. 2006 May;33(5):343-8 [16640540.001]
  • [Cites] Skinmed. 2006 Mar-Apr;5(2):83-6 [16603840.001]
  • [Cites] Semin Cutan Med Surg. 1999 Mar;18(1):78-83 [10188846.001]
  • [Cites] Dermatol Surg. 1997 Feb;23(2):105-10 [9107284.001]
  • [Cites] Am J Pathol. 1994 Jul;145(1):11-7 [8030743.001]
  • [Cites] Am J Dermatopathol. 1987 Oct;9(5):380-7 [2825558.001]
  • [Cites] Cancer. 1986 Jan 15;57(2):368-76 [3942970.001]
  • [Cites] Br J Dermatol. 1977 Aug;97(2):167-77 [334235.001]
  • [Cites] Cancer. 1975 Feb;35(2):457-63 [122913.001]
  • [Cites] Cancer. 1973 Jun;31(6):1541-52 [4709969.001]
  • [Cites] Am J Clin Pathol. 1969 Apr;51(4):487-92 [5774663.001]
  • [Cites] Pediatrics. 2002 Jun;109(6):1009-14 [12042536.001]
  • [Cites] Am J Clin Pathol. 2002 Jan;117(1):126-31 [11789717.001]
  • (PMID = 19554152.001).
  • [ISSN] 1195-2199
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2687503
  • [Keywords] NOTNLM ; Atypical fibroxanthoma / Histopathology / Immunohistochemistry / Mohs micrographic surgery
  •  go-up   go-down


88. Machak GN, Polotskiĭ BE, Meluzova OM, Chernov IS, Aliev MD: [Treatment of relapsed osteosarcoma. Role of chemotherapy using ifosamide and carboplatin]. Vopr Onkol; 2010;56(2):220-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Our investigation involved 27 patients with osteosarcoma and 2--malignant fibrous histiocytoma of long tubular bones treated at the Center's Clinics (2001-2008).
  • Surgical treatment used atypical resection of the lung or precision excision of metastasis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Bone Neoplasms / pathology. Histiocytoma, Malignant Fibrous / drug therapy. Neoplasm Recurrence, Local / surgery. Osteosarcoma / drug therapy

  • Genetic Alliance. consumer health - Osteosarcoma.
  • MedlinePlus Health Information. consumer health - Bone Cancer.
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Hazardous Substances Data Bank. ETOPOSIDE .
  • Hazardous Substances Data Bank. IFOSFAMIDE .
  • Hazardous Substances Data Bank. CARBOPLATIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20552902.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide
  •  go-up   go-down


89. Zaballos P, Llambrich A, Ara M, Olazarán Z, Malvehy J, Puig S: Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patients. Br J Dermatol; 2006 Feb;154(2):244-50
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The clinical diagnosis of dermatofibroma is commonly easy.
  • However, the differentiation of dermatofibroma from other cutaneous tumours is difficult in some instances, primarily in atypical cases and rare variants.
  • The clinical differential diagnosis of haemosiderotic or aneurysmal dermatofibroma must include melanoma and other melanocytic tumours, vascular neoplasms, adnexal tumours and nonspecific cysts.
  • Dermoscopy improves the diagnostic accuracy in pigmented and nonpigmented skin lesions.
  • CONCLUSIONS: This dermoscopic pattern yielded the diagnosis of haemosiderotic or aneurysmal dermatofibroma in most cases.
  • However, this multicomponent pattern may present in some melanomas and although it is useful in determining a clinical diagnosis of aneurysmal dermatofibroma, it may not be specific to this entity.
  • [MeSH-major] Dermoscopy. Hemosiderin / analysis. Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis

  • Genetic Alliance. consumer health - Dermatofibroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Br J Dermatol. 2007 Jan;156(1):199-200 [17199605.001]
  • (PMID = 16433792.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
  •  go-up   go-down


90. Balegno S, Ceroni M, Corato M, Franciotta D, Giometto B, Marinu-Aktipu K, Nano R: Antibodies to cerebellar nerve fibres in two patients with paraneoplastic cerebellar ataxia. Anticancer Res; 2005 Sep-Oct;25(5):3211-4
Genetic Alliance. consumer health - Ataxia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to characterize two new atypical anti-neuronal antibodies using an immunohistochemical method on rat cerebellum and Western blot techniques with primate cerebellar tissue and with recombinant neuronal proteins.
  • Atypical sera from two patients with paraneoplastic neurological syndromes associated with different tumours were detected.
  • Case number 1 presented cerebellar degeneration and Merkel cell carcinoma and case number 2 paraneoplastic brainstem encephalitis and malignant fibrous histiocytoma.
  • By immunohistochemistry, the two new atypical antibodies showed a similar fibrillar positivity in the molecular and granular layers and around the Purkinje cells.
  • [MeSH-minor] Animals. Axons / immunology. Axons / pathology. Carcinoma, Merkel Cell / blood. Carcinoma, Merkel Cell / immunology. Dendrites / immunology. Dendrites / pathology. Humans. Immunohistochemistry. Rats. Rats, Sprague-Dawley. Skin Neoplasms / blood. Skin Neoplasms / immunology

  • Genetic Alliance. consumer health - Cerebellar Ataxia.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16101129.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibodies
  •  go-up   go-down


91. Hornick JL, Fletcher CD: Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol; 2007 Mar;31(3):329-40
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cellular neurothekeomas are distinctive benign cutaneous tumors of uncertain histogenesis.
  • As relatively few cases have been reported, their clinical features and morphologic spectrum remain incompletely defined, and the significance of atypical histologic features is uncertain.
  • Fifty-two percent of the tumors were limited to the dermis, and 48% also involved superficial subcutaneous tissue.
  • In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform fibrohistiocytic tumor, benign fibrous histiocytoma, and a low-grade sarcoma.
  • Atypical histologic features (including pleomorphism, infiltration of subcutis, and a high mitotic rate) seem to have no clinical significance.
  • [MeSH-major] Neurothekeoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Sarcoma / diagnosis

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17325474.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


92. Morgan MB, Purohit C, Anglin TR: Immunohistochemical distinction of cutaneous spindle cell carcinoma. Am J Dermatopathol; 2008 Jun;30(3):228-32
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical distinction of cutaneous spindle cell carcinoma.
  • Cutaneous spindle cell squamous carcinoma is an uncommon variant of squamous cell carcinoma in which keratinocytes infiltrate the dermis as single cells with elongated nuclei rather than as cohesive nests or islands, and signs of keratinization of conventional squamous cell carcinoma are insubstantial or nonexistent.
  • Spindle cell carcinoma must be distinguished from spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, atypical fibroxanthoma (AFX), and scar.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cicatrix / diagnosis. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Immunohistochemistry. Keratinocytes / chemistry. Keratinocytes / pathology. Keratins / analysis. Leiomyosarcoma / diagnosis. Male. Melanoma / diagnosis. Middle Aged. Predictive Value of Tests

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18496422.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CK-34 beta E12; 68238-35-7 / Keratins
  •  go-up   go-down


93. Fernandez-Flores A: Cutaneous squamous cell carcinoma of different grades: variation of the expression of CD10. Cesk Patol; 2008 Oct;44(4):100-2
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous squamous cell carcinoma of different grades: variation of the expression of CD10.
  • Although it has been claimed that invasive cutaneous squamous cell carcinoma (SCC) does not express CD10, very few examples have been investigated regarding this matter.
  • 2) lack of cytoplasmic expression of CD10 by cutaneous SCC can be considered as an additional prognosis factor to investigate in the future;.
  • 3) our results seem contradictory to the current view that has defended atypical fibroxanthoma as an anaplastic type of SCC, since the former expresses CD10 in virtually 100 % of the cases.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Neprilysin / metabolism. Skin Neoplasms / pathology

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19069747.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


94. Scalvenzi M, Balato A, De Natale F, Francia MG, Mignogna C, De Rosa G: Hemosiderotic dermatofibroma: report of one case. Dermatology; 2007;214(1):82-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dermatofibroma (DF) is a common benign fibrohistiocytic lesion which presents with a wide variety of clinicopathological features.
  • Generally, the clinical diagnosis is easy, but differentiating it from other cutaneous tumors could be difficult in atypical cases and rare variants.
  • The differential diagnosis may comprise melanoma as well as other melanocytic and nonmelanocytic tumors.
  • We report the case of a 38-year-old man who presented with a hemosiderotic DF on the abdomen.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Dermoscopy. Diagnosis, Differential. Disease Progression. Humans. Male

  • Genetic Alliance. consumer health - Dermatofibroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17191053.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


95. Sachdev R, Sundram UN: Frequent positive staining with NKI/C3 in normal and neoplastic tissues limits its usefulness in the diagnosis of cellular neurothekeoma. Am J Clin Pathol; 2006 Oct;126(4):554-63
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequent positive staining with NKI/C3 in normal and neoplastic tissues limits its usefulness in the diagnosis of cellular neurothekeoma.
  • Recently, it resurfaced as a marker to separate cellular neurothekeoma from other dermal tumors in the differential diagnosis.
  • NKI/C3 is also positive in many dermal tumors of possible histiocytic origin, including juvenile xanthogranuloma (6/10), atypical fibroxanthoma (4/12), cellular fibrous histiocytoma (5/10), reticulohistiocytoma (3/6), and xanthoma (8/10).
  • Given the wide spectrum of positive staining in morphologic mimics of cellular neurothekeomas, pathologists should be cautious when making this diagnosis based solely on positive staining with NKI/C3.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Antigens, Neoplasm / immunology. Biomarkers, Tumor / immunology. Neurothekeoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. False Positive Reactions. Female. Humans. Immunohistochemistry. Male

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16938667.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
  •  go-up   go-down


96. Alba García JR, Armengot Carceller M, Zapater Latorre E, Pérez Valles A, Basterra Alegría A: Malignant fibrohistiocytoma of the parotid region. Report of a case. Med Oral Patol Oral Cir Bucal; 2008 Feb;13(2):E148-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant fibrohistiocytoma of the parotid region. Report of a case.
  • Most salivary gland tumors are benign, malignant lesions accounting for 15-30% of the total.
  • We present a case of malignant fibrohistiocytoma with atypical features due to its location (in the parotid region), size and rapid growth.
  • The definitive diagnosis requires microscopic study of the resection piece using immunohistochemical techniques.
  • [MeSH-major] Histiocytoma, Malignant Fibrous. Parotid Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18223534.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


97. Kovach BT, Boyd AS: Melanoma associated with a dermatofibroma. J Cutan Pathol; 2007 May;34(5):420-2
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Dermatofibromas are common benign cutaneous fibrohistiocytic neoplasms, whereas melanomas are potentially aggressive malignancies.
  • METHODS: We report the case of a 56-year-old female presenting with a firm pink papule on the left thigh.
  • RESULTS: Histopathology revealed atypical melanocytes in the epidermis and papillary dermis with numerous mitotic figures and intraepidermal pagetoid spread.
  • The atypical melanocytes stained for MART-1 and S-100, whereas the underlying fibrohistiocytic tumor took up factor XIIIa immunostain, confirming the diagnosis of invasive malignant melanoma occurring in association with a dermatofibroma.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

  • Genetic Alliance. consumer health - Dermatofibroma.
  • MedlinePlus Health Information. consumer health - Melanoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17448199.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


98. Ries S, Barr R, LeBoit P, McCalmont T, Waldman J: Cutaneous sarcomatoid B-cell lymphoma. Am J Dermatopathol; 2007 Feb;29(1):96-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous sarcomatoid B-cell lymphoma.
  • A rare case of a spindle cell (sarcomatoid) B-cell lymphoma is described.
  • Although there have been a few recent reports of cutaneous sarcomatoid lymphomas, this case is especially unusual because it presented as a scarlike plaque rather than a tumor and microscopically exhibited a prominent myxoid matrix.
  • Given these features, the lesion was initially interpreted as an atypical fibromucinosis.
  • The differential diagnosis included fibromucinous lesion consistent with variant of lichen myxedematosus, spindle cell carcinoma, spindle cell melanoma, atypical fibroxanthoma, and atypical smooth muscle tumors.
  • Subsequently, strong positive staining for LCA(CD45RB) and CD20 was demonstrated characteristic of a B-cell lymphoma.
  • Although all variants of cutaneous sarcomatoid B-cell lymphomas are rare, it is imperative to consider them in the differential diagnosis of otherwise difficult to categorize spindle cell proliferations.
  • [MeSH-major] Lymphoma, B-Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD20 / metabolism. Antigens, CD45 / metabolism. Diagnosis, Differential. Humans. Male. Middle Aged. Scalp / pathology. Scalp Dermatoses / diagnosis. Scalp Dermatoses / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17284972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20; EC 3.1.3.48 / Antigens, CD45
  •  go-up   go-down


99. Yang A, Hanley A, Velazquez EF, Cassarino DS: Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature. J Cutan Pathol; 2010 Apr;37(4):465-74
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous myxoid spindle cell squamous cell carcinoma: a clinicopathologic study and review of the literature.
  • Here, we report six cases of primary cutaneous and mucocutaneous SCC with prominent extracellular stromal mucin deposition and an epithelial spindle cell component.
  • We also propose a set of histologic and immunohistochemical findings for distinguishing MSC SCC from primary cutaneous and metastatic spindle cell neoplasms including other sarcomatoid carcinomas, myxoid sarcomas and the spindle cell variant of atypical fibroxanthoma (AFX).
  • Given the small numbers of cases reported to date, the presence of prominent myxoid stroma in primary cutaneous spindle cell SCC has unknown prognostic significance at this time.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19811587.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


100. Dotto JE, Glusac EJ: p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. J Cutan Pathol; 2006 Jun;33(6):413-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma.
  • BACKGROUND: Cutaneous spindle cell squamous cell carcinoma (SCSCC) is a rare variant of SCC.
  • This lesion is sometimes difficult to diagnose based purely on morphologic features. p63 is a member of the p53 gene family that can be identified in epithelial malignancies.
  • Control cases included desmoplastic melanoma (eight cases), atypical fibroxanthoma (AFX) (10 cases), dermatofibrosarcoma protuberans (eight cases), and cutaneous leiomyosarcoma (LMS) (four cases).
  • CONCLUSIONS: In the given differential diagnosis, p63 appears relatively specific to SCSCC and adds a useful nuclear marker to the available repertoire.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Membrane Proteins / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Nucleus / immunology. Cell Nucleus / metabolism. Dermatofibrosarcoma / diagnosis. Dermatofibrosarcoma / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Leiomyosarcoma / diagnosis. Leiomyosarcoma / metabolism. Male. Melanoma / diagnosis. Melanoma / metabolism. Middle Aged. Retrospective Studies. Xanthomatosis / diagnosis. Xanthomatosis / metabolism






Advertisement