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1. Thai D, Dyer JE, Jacob P, Haller CA: Clinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers. Clin Pharmacol Ther; 2007 Feb;81(2):178-84
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  • Some subjects exhibited slow oral clearance of BD, which tended to correlate with a variant haplotype of the alcohol dehydrogenase gene ADH-IB G143A.
  • BD was extensively converted to GHB after oral administration, but significant inter-individual variability in the rate of metabolism, possibly related to variants in ADH-IB, was observed.

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  • (PMID = 17192771.001).
  • [ISSN] 0009-9236
  • [Journal-full-title] Clinical pharmacology and therapeutics
  • [ISO-abbreviation] Clin. Pharmacol. Ther.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA 14935; United States / NIDA NIH HHS / DA / DA12393; United States / NCRR NIH HHS / RR / M01RR00083-41; United States / NIGMS NIH HHS / GM / T32 GM007546-28
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Butylene Glycols; 7G33012534 / Sodium Oxybate; 7XOO2LE6G3 / 1,4-butanediol; EC 1.1.1.1 / Alcohol Dehydrogenase; S88TT14065 / Oxygen
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2. Moncrief RM, Nayar R, Diaz LK, Staradub VL, Morrow M, Khan SA: A comparison of ductoscopy-guided and conventional surgical excision in women with spontaneous nipple discharge. Ann Surg; 2005 Apr;241(4):575-81
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  • INTRODUCTION: Radiologic imaging is routinely used to evaluate women with spontaneous nipple discharge (SND), but definitive diagnosis is usually only achieved by surgical terminal duct excision (TDE).
  • MATERIALS AND METHODS: We conducted a retrospective review of the records of 117 consecutive women who underwent ductoscopy to guide ductal excision (scope-DE) or received conventional TDE without ductoscopy.
  • Two women had atypical ductal lavage cytology and the remainder presented with SND from 1 or more duct.
  • RESULTS: Fifty-nine women underwent scope-DE, and 58 underwent conventional TDE.
  • The proportion of women with intraductal neoplasia was slightly greater in the group undergoing scope-DE (88% vs. 81%, P = 0.2).
  • In the conventional TDE group, 8.5% were found to have atypical hyperplasia or duct carcinoma in situ compared with 18.6% in the scope-DE group.

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  • (PMID = 15798458.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA089018; United States / NCI NIH HHS / CA / P50 CA89018
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1357060
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3. Vallet A, Santarelli X, Lonvaud-Funel A, de Revel G, Cabanne C: Purification of an alcohol dehydrogenase involved in the conversion of methional to methionol in Oenococcus oeni IOEB 8406. Appl Microbiol Biotechnol; 2009 Feb;82(1):87-94
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  • Alcohol dehydrogenase (ADH) activity was found to be present in the soluble fraction of O. oeni IOEB 8406.
  • An NAD(P)H-dependent ADH involved in the reduction of methional was then purified to homogeneity.
  • Despite the great importance of ADH activities in wine flavor modification, this is the first report of the purification of an ADH isolated from O. oeni.
  • The purified ADH does not seem to be involved in the modification of buttery and lactic notes or to be involved in the specific formation of volatile alcohols during MLF.
  • The function of the purified ADH remains unclear, although the role of the sulfur atom in methional molecules in the interaction between enzyme and substrate was evidenced.

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  • (PMID = 18850096.001).
  • [ISSN] 1432-0614
  • [Journal-full-title] Applied microbiology and biotechnology
  • [ISO-abbreviation] Appl. Microbiol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Bacterial Proteins; 0AAO8V0F1R / methional; AE28F7PNPL / Methionine; EC 1.1.1.1 / Alcohol Dehydrogenase
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4. Cho YH, Gitelman S, Rosenthal S, Ambler G: Long-term outcomes in a family with nephrogenic syndrome of inappropriate antidiuresis. Int J Pediatr Endocrinol; 2009;2009:431527
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  • The proband and one maternal uncle presented in their infancy with severe recurrent hyponatremia, and clinical pictures consistent with the syndrome of inappropriate antidiuretic hormone (SIADH) in the absence of an elevated ADH level.

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  • (PMID = 20148077.001).
  • [ISSN] 1687-9856
  • [Journal-full-title] International journal of pediatric endocrinology
  • [ISO-abbreviation] Int J Pediatr Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2817859
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5. Yang J, Ren Y, Wang L, Li B, Chen Y, Zhao W, Xu W, Li T, Dai F: PTEN mutation spectrum in breast cancers and breast hyperplasia. J Cancer Res Clin Oncol; 2010 Sep;136(9):1303-11
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  • [Title] PTEN mutation spectrum in breast cancers and breast hyperplasia.
  • The present study aims to investigate the role of PTEN mutation in breast carcinogenesis by analyzing PTEN mutation spectrum and the protein expression in breast cancers, adjacent hyperplastic lesions, benign breast lesions and normal breast tissues.
  • METHODS: All 9 exons of PTEN gene were amplified by PCR with DNA extracted from 50 of human breast cancers and corresponding adjacent breast hyperplasia tissues, adjacent normal breast tissues, as well as 50 breast benign lesions residing in or around Yunnan, China, respectively.
  • RESULTS: PTEN mutations were detected in 11 of 50 (22%) breast cancers and 4 of 50 (8%) adjacent ductal hyperplasia, all of which were atypical ductal hyperplasia and same PTEN mutation were detected in the corresponding cancer tissues.
  • No PTEN mutation was detected in all adjacent normal breast tissues and 50 cases of breast benign lesions.
  • Immunohistochemical analysis showed that 24 of 50 (48%) breast cancers and 6 of 50 (12%) adjacent breast hyperplasia demonstrated negative immuno-staining of PTEN (loss of PTEN protein expression).
  • All the 4 adjacent breast tissues harbored PTEN mutations and 9 of 11 breast cancers with PTEN mutation were loss of PTEN expression.
  • CONCLUSIONS: The incidence of PTEN mutations is relatively high in patients with sporadic breast cancer in the region of Yunnan, China and exists at the early stage of breast cancer development.
  • The PTEN mutations have significant effect on the expression silencing of PTEN protein indicating the important role of PTEN mutation in carcinogenesis of breast cancers.
  • [MeSH-major] Breast Neoplasms / genetics. Breast Neoplasms / pathology. Mutation / genetics. PTEN Phosphohydrolase / genetics
  • [MeSH-minor] Adult. Aged. Female. Humans. Hyperplasia / genetics. Hyperplasia / metabolism. Hyperplasia / pathology. Immunohistochemistry. In Situ Hybridization, Fluorescence. Middle Aged. Polymerase Chain Reaction. Sequence Analysis, DNA

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  • (PMID = 20300775.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.1.3.67 / PTEN protein, human
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6. Tonegutti M, Girardi V: Stereotactic vacuum-assisted breast biopsy in 268 nonpalpable lesions. Radiol Med; 2008 Feb;113(1):65-75
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  • [Title] Stereotactic vacuum-assisted breast biopsy in 268 nonpalpable lesions.
  • PURPOSE: We evaluated the reliability of stereotactic vacuum-assisted breast biopsies (VAB) from our personal experience.
  • Inclusion criteria were nonpalpable lesions, undetectable by ultrasound and suspected at mammography (microcalcifications, circumscribed mass, architectural distortion), for which cytology and/or core biopsy could not provide a definite diagnosis.
  • On the basis of the Breast Imaging Reporting and Data System (BI-RADS) classification, 16 cases (7%) were graded as highly suspicious for malignancy (BI-RADS 5), 81 (34%) as suspicious for malignancy (BI-RADS 4b), 97 (40%) as indeterminate (BI-RADS 4a) and 46 (19%) as probably benign (BI-RADS 3).
  • RESULTS: In 28/268 lesions (10.5%) the biopsy could not be performed (nonidentification of the lesion; inaccessibility due to location or breast size).
  • Among the malignant lesions, 16/100 (16%) were invasive carcinoma [infiltrating ductal carcinoma (IDC) or infiltrating lobular carcinoma (ILC)], 13/100 (13%) were microinvasive (T1mic), 35/100 (35%) were ductal carcinoma in situ (DCIS), 9/100 (9%) were lobular carcinoma in situ (CLIS).
  • Among the borderline lesions, 27/100 (27%) were atypical epithelial hyperplasia [atypical ductal hyperplasia (ADH) or atypical lobular hyperplasia (ALH)].
  • In 9/100 surgically treated lesions (9%), there was discordance between the microhistological findings of VAB and the pathological results of the surgical procedure: 8/9 were underestimated by VAB (four ADH vs. DCIS, three DCIS vs. IDC, one ADH vs. IDC), and 1/9 was overestimated (T1mic vs. DCIS).
  • CONCLUSIONS: In our experience, VAB showed fair reliability in the diagnosis of nonpalpable breast lesions despite a portion of failed (10.5%), nonsignificant (5%) procedures and underestimated lesions (9%).
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Stereotaxic Techniques
  • [MeSH-minor] Adult. Aged. Calcinosis / diagnostic imaging. Calcinosis / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Lobular / pathology. Diagnosis, Differential. Female. Humans. Hyperplasia. Mammary Glands, Human / pathology. Mammography. Middle Aged. Neoplasm Invasiveness. Reproducibility of Results. Vacuum

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  • (PMID = 18338128.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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7. Perkins RM, Yuan CM, Welch PG: Dipsogenic diabetes insipidus: report of a novel treatment strategy and literature review. Clin Exp Nephrol; 2006 Mar;10(1):63-7
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  • Results of extensive water testing revealed intact urinary concentrating and diluting capacity, physiologic though blunted antidiuretic hormone (ADH) release, and an abnormally low thirst threshold, consistent with the diagnosis of dipsogenic diabetes insipidus.
  • Dipsogenic diabetes insipidus is an uncommonly (and not universally) recognized disorder, requiring monitored testing in order to distinguish it from incomplete forms of central diabetes insipidus.

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  • (PMID = 16544179.001).
  • [ISSN] 1342-1751
  • [Journal-full-title] Clinical and experimental nephrology
  • [ISO-abbreviation] Clin. Exp. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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8. Fukuda T, Yokoyama J, Nakamura T, Song IJ, Ito T, Ochiai T, Kanno A, Kameya T, Maki M: Molecular phylogeny and evolution of alcohol dehydrogenase (Adh) genes in legumes. BMC Plant Biol; 2005;5:6
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  • [Title] Molecular phylogeny and evolution of alcohol dehydrogenase (Adh) genes in legumes.
  • The aim of our study is to isolate the alcohol dehydrogenase (Adh) genes in two distantly related legumes, and use these sequences to examine the molecular evolutionary history of this nuclear gene.
  • RESULTS: We isolated the expressed Adh genes from two species of legumes, Sophora flavescens Ait. and Wisteria floribunda DC., by a RT-PCR based approach and found a new Adh locus in addition to homologues of the Adh genes found previously in legumes.
  • To examine the evolution of these genes, we compared the species and gene trees and found gene duplication of the Adh loci in the legumes occurred as an ancient event.
  • CONCLUSION: This is the first report revealing that some legume species have at least two Adh gene loci belonging to separate clades.

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  • (PMID = 15836788.001).
  • [ISSN] 1471-2229
  • [Journal-full-title] BMC plant biology
  • [ISO-abbreviation] BMC Plant Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB191334/ AB191335/ AB191336/ AB191337/ AB191338/ AB191339
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ PMC1112602
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9. Suzuki S, Goto M, Okamoto T, Tomita I, Murayama A, Sawa M, Noguchi Y, Hoshikawa Y, Shimizu A: [A case of small cell carcinoma of the esophagus with SIADH]. Gan To Kagaku Ryoho; 2010 Jan;37(1):123-6
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  • Under diagnosis of small cell carcinoma of the esophagus at Stage IVa, neoadjuvant chemotherapy with FP (5-FU+CDDP) was given.
  • Pathological examination with IHC demonstrated positive staining for CD56, NSE and synaptophysin but negative for ADH.
  • [MeSH-major] Carcinoma, Small Cell / complications. Esophageal Neoplasms / complications. Inappropriate ADH Syndrome / etiology

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  • (PMID = 20087045.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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10. Ogueta M, Cibik O, Eltrop R, Schneider A, Scholz H: The influence of Adh function on ethanol preference and tolerance in adult Drosophila melanogaster. Chem Senses; 2010 Nov;35(9):813-22
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  • [Title] The influence of Adh function on ethanol preference and tolerance in adult Drosophila melanogaster.
  • We also investigated whether Drosophila preference, sensitivity and tolerance to ethanol was related to the activity of alcohol dehydrogenase (Adh), the primary ethanol-metabolizing enzyme in D. melanogaster.
  • Impaired Adh function reduced ethanol preference in both D. melanogaster and a related species, D. sechellia.
  • Adh-impaired flies also displayed reduced aversion to high ethanol concentrations, increased sensitivity to the effects of ethanol on postural control, and negative tolerance/sensitization (i.e., a reduction of the increased resistance to ethanol's effects that normally occurs upon repeated exposure).
  • These data strongly indicate a linkage between ethanol-induced behavior and ethanol metabolism in adult fruit flies: Adh deficiency resulted in reduced preference to low ethanol concentrations and reduced aversion to high ones, despite recovery from ethanol being strongly impaired.

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  • (PMID = 20739429.001).
  • [ISSN] 1464-3553
  • [Journal-full-title] Chemical senses
  • [ISO-abbreviation] Chem. Senses
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alcohols; 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase
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11. Shafe S, Gilder DA, Montane-Jaime LK, Josephs R, Moore S, Crooks H, Ramcharam C, Ehler CL: Co-morbidity of alcohol dependence and select affective and anxiety disorders among individuals of East Indian and African ancestry in Trinidad and Tobago. West Indian Med J; 2009 Mar;58(2):164-72
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  • A blood sample was obtained and used to genotype for the presence of ADH and ALDH1 polymorphisms and serum levels of hepatic enzymes.
  • Co-morbidity of major depressive disorder with alcohol dependence is common in the two major ethnic groups in Trinidad and Tobago and appears to be as likely the consequence of drinking and/or drug use, as the cause.

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  • (PMID = 20953317.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / P50 AA006420; United States / NIAAA NIH HHS / AA / AA014370-03; United States / NIAAA NIH HHS / AA / R21 AA014370-03; United States / NIAAA NIH HHS / AA / AA006420; United States / NIAAA NIH HHS / AA / AA014370; United States / NIAAA NIH HHS / AA / P60 AA006420-250023; United States / NIAAA NIH HHS / AA / AA006420-250023; United States / NIAAA NIH HHS / AA / P60 AA006420; United States / NIAAA NIH HHS / AA / R21 AA014370
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Jamaica
  • [Chemical-registry-number] EC 1.4.1.1 / Alanine Dehydrogenase
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12. Starek A, Szabla J, Starek-Swiechowicz B: Pyrazole and methylpyrazole for the treatment of 2-butoxyethanol poisoning. Acta Pol Pharm; 2007 Jan-Feb;64(1):93-100
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  • These data confirm the beneficial role of alcohol dehydrogenase (ADH) inhibitors in BE intoxication.

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  • (PMID = 17665857.001).
  • [ISSN] 0001-6837
  • [Journal-full-title] Acta poloniae pharmaceutica
  • [ISO-abbreviation] Acta Pol Pharm
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antidotes; 0 / Ethylene Glycols; 0 / Pyrazoles; 3QD5KJZ7ZJ / pyrazole; 83LCM6L2BY / fomepizole; EC 1.1.1.1 / Alcohol Dehydrogenase; I0P9XEZ9WV / n-butoxyethanol
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13. Pozzessere D, Zafarana E, Buccoliero AM, Pratesi C, Fargnoli R, Di Leo A: Gastric cancer metastatic to the pituitary gland: a case report. Tumori; 2007 Mar-Apr;93(2):217-9
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  • Basal endocrinological work-up showed corticotroph, gonadotroph, somatotroph and thyrotroph cell insufficiency; serum PRL was elevated and no deficit of the ADH level was observed.
  • After diagnosis the patient began thyroid and adrenal-replacement therapy and was referred to Radiotherapy Unit for treatment on the sellar and pituitary gland region.


14. Quigley R, Chu PY, Huang CL: Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability. J Membr Biol; 2005 Apr;204(3):109-16
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  • [Title] Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability.
  • The mammalian renal collecting duct increases its water permeability in response to antidiuretic hormone (ADH).
  • ADH causes cytoplasmic endosomes containing the water channel, aquaporin 2 (AQP 2), to fuse with the apical membrane so that the water permeability of the tubule increases many times above baseline.
  • In the present study, we examined the role of SNARE proteins in the insertion of water channels in the collecting-duct response to ADH by using botulinum toxins A, B and C.
  • ADH (200 pM) was then added to the bath after baseline measurements of osmotic water permeability (P(f)) and the change in P(f) was followed for one hour.
  • Thus, SNARE proteins are involved in the insertion of the water channels in the collecting duct.

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  • (PMID = 16245033.001).
  • [ISSN] 0022-2631
  • [Journal-full-title] The Journal of membrane biology
  • [ISO-abbreviation] J. Membr. Biol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK54368
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aquaporin 2; 0 / Aquaporins; 0 / SNARE Proteins; 0 / Vesicular Transport Proteins; 059QF0KO0R / Water; 11000-17-2 / Vasopressins; EC 3.4.24.69 / Botulinum Toxins
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15. Fadare O, Clement NF, Ghofrani M: High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision. Diagn Pathol; 2009;4:26
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  • [Title] High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision.
  • Low and high-grade ductal carcinoma in-situ (DCIS) are known to be highly disparate by a multitude of parameters, including progression potential, immunophenotype, gene expression profile and DNA ploidy.
  • In this study, we analyzed a group of intermediate and high-grade DCIS cases to determine how well the core biopsy predicts the maximal pathology in the associated excisions, and to determine if there are any core biopsy morphologic features that may predict a close (< or = 0.2 cm) or positive margin in the subsequent excision.
  • Forty-nine consecutive paired specimens [core biopsies with a maximal diagnosis of DCIS, and their corresponding excisions, which included 20 and 29 specimens from mastectomies and breast conserving surgeries respectively] were evaluated in detail.
  • In another 4 cases, the changes were diagnostic only of atypical ductal hyperplasia.
  • Among the 40 cases with at least residual DCIS in the excision, there were 5 cases in which comedo-pattern DCIS was present in the excision but not in the core biopsy, attributed to the lower maximal nuclear grade in the biopsy proliferation in 4 cases and the absence of central necrosis in the 5th.
  • In 6(15%) of the 40 cases, the maximum nuclear grade of the excision (grade 3) was higher than that seen in the core biopsy (grade 2).
  • Overall, however, the maximum nuclear grade in the excision was significantly predicted by maximum nuclear grade in the core biopsy (p = 0.028), with a Phi of 0.347, indicating a moderately strong association.
  • Finally, among a variety of core biopsy features that were evaluated, including maximum nuclear grade, necrosis, cancerization of lobules, number of tissue cores with DCIS, number of DCIS ducts per tissue core, total DCIS ducts, or comedo-pattern, only necrosis was significantly associated with a positive or close (< or = 0.2 cm) margin on multivariate analysis (Phi of 0.350).
  • It is concluded that a significant change [to invasive disease (14%) or to no residual disease (10%)] is seen in approximately 24% of excisions that follow a core biopsy diagnosis of intermediate or high-grade DCIS.

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  • (PMID = 19691836.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2740842
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16. Otto B, Riepl RL, Otto C, Klose J, Enck P, Klosterhalfen S: mu-Opiate receptor agonists -- a new pharmacological approach to prevent motion sickness? Br J Clin Pharmacol; 2006 Jan;61(1):27-30
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  • Plasma antidiuretic hormone (ADH), adrenocorticotropic hormone (ACTH) and nausea ratings were investigated.
  • ACTH (P < 0.05) and ADH levels (P < 0.02) increased significantly in both settings, but were lower after loperamide.

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  • (PMID = 16390348.001).
  • [ISSN] 0306-5251
  • [Journal-full-title] British journal of clinical pharmacology
  • [ISO-abbreviation] Br J Clin Pharmacol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Opioid, mu; 11000-17-2 / Vasopressins; 6X9OC3H4II / Loperamide; 9002-60-2 / Adrenocorticotropic Hormone
  • [Other-IDs] NLM/ PMC1884979
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17. Diebold T, Hahn T, Solbach C, Rody A, Balzer JO, Hansmann ML, Marx A, Viana F, Peters J, Jacobi V, Kaufmann M, Vogl TJ: Evaluation of the stereotactic 8G vacuum-assisted breast biopsy in the histologic evaluation of suspicious mammography findings (BI-RADS IV). Invest Radiol; 2005 Jul;40(7):465-71
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  • [Title] Evaluation of the stereotactic 8G vacuum-assisted breast biopsy in the histologic evaluation of suspicious mammography findings (BI-RADS IV).
  • PURPOSE: The purpose of this study was to evaluate the potential of the new 8G stereotactic vacuum-assisted breast biopsy (ST-driver, Mammotome; Ethicon Endosurgery) in the histologic evaluation of BI-RADS IV microcalcifications.
  • MATERIALS AND METHODS: Fifty-eight patients with 61 mammographic BI-RADS IV microcalcifications underwent stereotactic vacuum-assisted breast biopsy (SVAB).
  • Those 2 patients showed evidence of severe bleeding into the breast tissue and operative revision had to be performed (3.5%).
  • The histologic findings with further operative workup were: 10 ductal carcinomas in situ (DCIS), 4 atypical ductal hyperplasias, 1 atypical lobular hyperplasias (ALH), 3 lobular carcinomas in situ (LCIS), and 6 invasive ductal carcinomas.
  • In 1 of 12 patients with an initial DCIS histology, operative histology revealed invasive ductal cancer (8.3%).
  • Most frequent benign histologies were mastopathy (13), ductal hyperplasia (9), fibroadenoma (8), and sclerosing adenosis (5).
  • CONCLUSION: The 11-G SVAB has proven to be a perfect adjunct to the existing breast biopsy methods.
  • [MeSH-major] Biopsy, Needle / instrumentation. Breast / pathology. Breast Neoplasms / pathology. Mammography. Vacuum

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  • (PMID = 15973139.001).
  • [ISSN] 0020-9996
  • [Journal-full-title] Investigative radiology
  • [ISO-abbreviation] Invest Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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18. Nagi CS, O'Donnell JE, Tismenetsky M, Bleiweiss IJ, Jaffer SM: Lobular neoplasia on core needle biopsy does not require excision. Cancer; 2008 May 15;112(10):2152-8
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  • [Title] Lobular neoplasia on core needle biopsy does not require excision.
  • BACKGROUND: Lobular neoplasia (LN), encompassing atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS), is often an incidental finding on core needle biopsies (CNBs) performed in instances of radiologic densities and/or calcifications.
  • Because LN is generally considered a risk factor for breast carcinoma, the utility of subsequent excision is controversial.
  • Cases containing LN accompanied by a second lesion mandating excision (eg, radial scar, atypical ductal hyperplasia [ADH]) and those failing to meet strict diagnostic criteria for LN (eg, atypical cells, mitoses, single-cell necrosis) were excluded.
  • The remaining 3 patients had biopsies with the following findings: ADH in 1 biopsy, residual LCIS and a separate minute focus of infiltrating lobular carcinoma (clearly an incidental finding) in the second biopsy, and ductal carcinoma in situ admixed with LCIS in the third biopsy (a retrospective examination performed by 2 blinded breast pathologists revealed foci of atypical cells and mitoses).
  • 1) careful radiographic-pathologic correlation is performed; and 2) strict histologic criteria are adhered to when making the diagnosis.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma in Situ / surgery. Carcinoma, Lobular / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Middle Aged. Retrospective Studies. Risk Factors

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18348299.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Manríquez D, El-Sharkawy I, Flores FB, El-Yahyaoui F, Regad F, Bouzayen M, Latché A, Pech JC: Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics. Plant Mol Biol; 2006 Jul;61(4-5):675-85
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  • Alcohol dehydrogenases (ADH) participate in the biosynthetic pathway of aroma volatiles in fruit by interconverting aldehydes to alcohols and providing substrates for the formation of esters.
  • Two highly divergent ADH genes (15% identity at the amino acid level) of Cantaloupe Charentais melon (Cucumis melo var.
  • Cm-ADH1 belongs to the medium-chain zinc-binding type of ADHs and is highly similar to all ADH genes expressed in fruit isolated so far.
  • Both Cm-ADH proteins are much more active as reductases with K (m)s 10-20 times lower for the conversion of aldehydes to alcohols than for the dehydrogenation of alcohols to aldehydes.
  • Both Cm-ADH genes are expressed specifically in fruit and up-regulated during ripening.
  • Gene expression as well as total ADH activity are strongly inhibited in antisense ACC oxidase melons and in melon fruit treated with the ethylene antagonist 1-methylcyclopropene (1-MCP), indicating a positive regulation by ethylene.
  • These data suggest that each of the Cm-ADH protein plays a specific role in the regulation of aroma biosynthesis in melon fruit.

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  • (PMID = 16897483.001).
  • [ISSN] 0167-4412
  • [Journal-full-title] Plant molecular biology
  • [ISO-abbreviation] Plant Mol. Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ ABC02081/ ABC02082
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aldehydes; 0U46U6E8UK / NAD; 53-59-8 / NADP; EC 1.1.1.1 / Alcohol Dehydrogenase
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20. Espinosa A, Perdrizet G, Paz-Y-Miño C G, Lanfranchi R, Phay M: Effects of iron depletion on Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) and trophozoite growth: implications for antiamoebic therapy. J Antimicrob Chemother; 2009 Apr;63(4):675-8
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  • Fe2+ is a cofactor for E. histolytica alcohol dehydrogenase 2 (EhADH2), an essential bifunctional enzyme [alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)] in the glycolytic pathway of E. histolytica.
  • METHODS: We tested the effects of iron depletion on trophozoite growth, the kinetics of iron binding to EhADH2, and the activities of ADH and ALDH.
  • RESULTS: Growth of E. histolytica trophozoites, and ADH and ALDH enzymatic activities were directly inhibited by iron chelation.
  • Kinetics of iron binding to EhADH2 reveals the differential iron affinity of ADH (higher) and ALDH (lower).

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  • (PMID = 19218278.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / 2 P20 RR16457-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iron Chelating Agents; E1UOL152H7 / Iron; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / Aldehyde Dehydrogenase
  • [Other-IDs] NLM/ PMC2721693
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21. Caseli L, Perinotto AC, Viitala T, Zucolotto V, Oliveira ON Jr: Immobilization of alcohol dehydrogenase in phospholipid Langmuir-Blodgett films to detect ethanol. Langmuir; 2009 Mar 3;25(5):3057-61
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  • Here we show that alcohol dehydrogenase (ADH) has high affinity toward a negatively charged phospholipid, dimyristoylphosphatidic acid (DMPA), which forms a Langmuir monolayer at an air-water interface.
  • Incorporation of ADH into the DMPA monolayer was monitored with surface pressure measurements and polarization-modulation infrared reflection absorption spectroscopy, with the alpha-helices from ADH being mainly oriented parallel to the water surface.
  • ADH remained at the interface even at high surface pressures, thus allowing deposition of Langmuir-Blodgett (LB) films from the DMPA-ADH film.
  • Indeed, interaction with DMPA enhances the transfer of ADH, where the mass transferred onto a solid support increased from 134 ng for ADH on a Gibbs monolayer to 178 ng for an LB film with DMPA.
  • With fluorescence spectroscopy it was possible to confirm that the ADH structure was preserved even after one month of the LB deposition.
  • ADH-containing films deposited onto gold-interdigitated electrodes were employed in a sensor array capable of detecting ethanol at concentrations down to 10 ppb (in volume), using impedance spectroscopy as the method of detection.

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  • (PMID = 19437773.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Buffers; 0 / Enzymes, Immobilized; 0 / Phospholipids; 059QF0KO0R / Water; 3K9958V90M / Ethanol; 701-56-4 / N,N-dimethyl-4-anisidine; EC 1.1.1.1 / Alcohol Dehydrogenase
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22. Eanes WF, Merritt TJ, Flowers JM, Kumagai S, Zhu CT: Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster. Genetics; 2009 Feb;181(2):607-14
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  • Many studies of alcohol adaptation in Drosophila melanogaster have focused on the Adh polymorphism, yet the metabolic elimination of alcohol should involve many enzymes and pathways.
  • We have created a set of P-element-excision-derived Gpdh, Mdh1, and Adh alleles that generate a range of activity phenotypes from full to zero activity.
  • Finally, we examine the interactions between activity genotypes for Gpdh, Mdh1, and Adh.
  • Observations on Mdh1 in both Gpdh and Adh backgrounds demonstrate significant increases in ethanol tolerance with partial reductions (50%) in cytosolic MDH activity.

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  • (PMID = 19033156.001).
  • [ISSN] 0016-6731
  • [Journal-full-title] Genetics
  • [ISO-abbreviation] Genetics
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM045247; United States / NIGMS NIH HHS / GM / GM-45247
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; EC 1.1.- / Glycerolphosphate Dehydrogenase; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.37 / Malate Dehydrogenase
  • [Other-IDs] NLM/ PMC2644950
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23. Ingegnoli A, d'Aloia C, Frattaruolo A, Pallavera L, Martella E, Crisi G, Zompatori M: Flat epithelial atypia and atypical ductal hyperplasia: carcinoma underestimation rate. Breast J; 2010 Jan-Feb;16(1):55-9
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  • [Title] Flat epithelial atypia and atypical ductal hyperplasia: carcinoma underestimation rate.
  • This study was carried out to determine the underestimation rate of carcinoma upon surgical biopsy after a diagnosis of flat epithelial atypia and atypical ductal hyperplasia and 11-gauge vacuum-assisted breast biopsy.
  • A retrospective review was conducted of 476 vacuum-assisted breast biopsy performed from May 2005 to January 2007 and a total of 70 cases of atypia were identified.
  • Fifty cases (71%) were categorized as pure atypical ductal hyperplasia, 18 (26%) as pure flat epithelial atypia and two (3%) as concomitant flat epithelial atypia and atypical ductal hyperplasia.
  • Surgical biopsy was performed in 44 patients with atypical ductal hyperplasia, 15 patients with flat epithelial atypia, and two patients with flat epithelial atypia and atypical ductal hyperplasia.
  • Five cases of atypical ductal hyperplasia were upgraded to ductal carcinoma in situ, three cases of flat epithelial atypia yielded one ductal carcinoma in situ and two cases of invasive ductal carcinoma, and one case of flat epithelial atypia/atypical ductal hyperplasia had invasive ductal carcinoma.
  • The overall rate of malignancy was 16% for atypical ductal hyperplasia (including flat epithelial atypia/atypical ductal hyperplasia patients) and 20% for flat epithelial atypia.
  • The presence of flat epithelial atypia and atypical ductal hyperplasia at biopsy requires careful consideration, and surgical excision should be suggested.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Hyperplasia / epidemiology. Hyperplasia / pathology. Immunohistochemistry. Incidence. Male. Mammography / methods. Middle Aged. Prognosis. Retrospective Studies. Risk Assessment

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  • (PMID = 19825003.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Meteoglu I, Dikicioglu E, Erkus M, Culhaci N, Kacar F, Ozkara E, Uyar M: Breast carcinogenesis. Transition from hyperplasia to invasive lesions. Saudi Med J; 2005 Dec;26(12):1889-96
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  • [Title] Breast carcinogenesis. Transition from hyperplasia to invasive lesions.
  • OBJECTIVES: To examine the balance loss between proliferation and apoptosis that play a role in breast cancer development, and to explore the places of various genes and molecules within this process in this supposed multistep process.
  • We categorized the lesions ductal hyperplasia (DH), atypical ductal hyperplasia (ADH), in situ ductal carcinoma (DCIS), and invasive ductal carcinoma (IDC).
  • We determined the tumor size, histological grade and lymph node status of invasive cases and we used nottingham prognostic index (NPI).
  • We applied ER, PR, c-erbB2, p53, Ki-67, bcl-2, dUTP nick end labeling (TUNEL), breast cancer gene-1, matrix metalloproteinases-1 and tissue inhibitor matrix metalloproteinases-1 stains to each lesion using the immunohistochemical method.
  • RESULTS: We observed that ER and PR decreased in ADH when compared with DH (p=0.0001 and p=0.019).
  • However, we determined that in DCIS as c-erbB2 (p=0.005) and Ki-67 (p=0.004) increase, TUNEL (p=0.04) and bcl-2 (p=0.005) decrease, when compared with ADH.
  • We detected higher PR (p=0.049), lower TUNEL and c-erbB2 (p=0.017) in low grade group of NPI, when compared with high grade group of NPI.
  • CONCLUSION: As a result, it has been shown that together with increase in proliferation, decrease in apoptosis, too, contributes to the proliferation/apoptosis imbalance that occurs in breast carcinogenesis.
  • We also showed that the changes, beginning with loss of ER and PR in ADH step, can cause malign transformation, which is especially notable both in DCIS step due to Ki-67 and c-erbB2 increase, and also with bcl-2 and TUNEL decrease.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Breast Neoplasms / physiopathology. Cell Transformation, Neoplastic / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Adult. Aged. Apoptosis / physiology. Biopsy, Needle. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / physiopathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / physiopathology. Cell Proliferation. Female. Humans. Hyperplasia / pathology. Hyperplasia / physiopathology. Immunohistochemistry. In Situ Nick-End Labeling. Middle Aged. Neoplasm Staging. Probability. Sampling Studies. Statistics, Nonparametric. Tissue Culture Techniques


25. Li SY, Ren J: Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. J Mol Cell Cardiol; 2008 Jun;44(6):992-1001
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  • This study examined the impact of augmented acetaldehyde exposure on myocardial function, geometry, and insulin signaling via cardiac-specific overexpression of alcohol dehydrogenase (ADH).
  • ADH transgenic and wild-type FVB mice were placed on a 4% alcohol diet for 12 weeks.
  • Mice consuming alcohol exhibited glucose intolerance, dampened cardiac glucose uptake, cardiac hypertrophy and contractile dysfunction, all of which with the exception of whole body glucose tolerance were exaggerated by the ADH transgene.
  • ADH-augmented alcohol-induced effect of IRS-1 phosphorylation (tyrosine/serine).
  • Neither alcohol nor adh affected expression of insulin receptor and IRS-1.
  • Alcohol reduced phosphorylation of Akt and GSK-3beta as well as GSK-3beta expression and the effect was exaggerated by ADH.
  • The transcriptional factors GATA4, c-jun and c-jun phosphorylation were upregulated by alcohol, which was amplified by ADH.
  • Chronic alcohol intake upregulated expression of the endoplasmic reticulum stress markers eIF2alpha, IRE-1alpha, GRP78 and gadd153, the effect of which was exaggerated by ADH.
  • These data suggest that elevated cardiac acetaldehyde exposure via ADH may exacerbate alcohol-induced myocardial dysfunction, hypertrophy, insulin insensitivity and ER stress, indicating a key role of ADH gene in alcohol-induced cardiac dysfunction and insulin resistance.

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  • (PMID = 18377926.001).
  • [ISSN] 1095-8584
  • [Journal-full-title] Journal of molecular and cellular cardiology
  • [ISO-abbreviation] J. Mol. Cell. Cardiol.
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / R01 AA013412-03; United States / NIAAA NIH HHS / AA / AA013412-05; United States / NIAAA NIH HHS / AA / R01 AA013412-05; United States / NIAAA NIH HHS / AA / AA013412-02; United States / NCRR NIH HHS / RR / P20 RR016474-08; United States / NCRR NIH HHS / RR / P20 RR016474; United States / NIAAA NIH HHS / AA / R01 AA013412-02; United States / NCRR NIH HHS / RR / 5P20RR016474; United States / NIAAA NIH HHS / AA / R01 AA013412; United States / NIAAA NIH HHS / AA / AA013412-03; United States / NIAAA NIH HHS / AA / R01 AA013412-04; United States / NIAAA NIH HHS / AA / R01 AA013412-01A2; United States / NIAAA NIH HHS / AA / 1R01 AA013412; United States / NIAAA NIH HHS / AA / AA013412-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Central Nervous System Depressants; 0 / Ddit3 protein, mouse; 0 / Eukaryotic Initiation Factor-2; 0 / GATA4 Transcription Factor; 0 / Gata4 protein, mouse; 0 / Heat-Shock Proteins; 0 / Insulin; 0 / Insulin Receptor Substrate Proteins; 0 / Irs1 protein, mouse; 0 / Molecular Chaperones; 0 / molecular chaperone GRP78; 147336-12-7 / Transcription Factor CHOP; 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 2.7.11.1 / Ern1 protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3; EC 3.1.- / Endoribonucleases; GO1N1ZPR3B / Acetaldehyde; IY9XDZ35W2 / Glucose
  • [Other-IDs] NLM/ NIHMS56327; NLM/ PMC2501109
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26. Varret M, Abifadel M, Rabès JP, Boileau C: Genetic heterogeneity of autosomal dominant hypercholesterolemia. Clin Genet; 2008 Jan;73(1):1-13
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  • Autosomal dominant hypercholesterolemia (ADH) is characterized by isolated elevation of plasmatic low-density lipoprotein cholesterol associated with high risk of premature cardiovascular complications.
  • We have shown further heterogeneity with the discovery of missense mutations in the PCSK9 gene resulting in ADH.
  • Altogether, numerous reports give evidence for the existence of a greater level of genetic heterogeneity in ADH and the involvement of still unknown genes.

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  • (PMID = 18028451.001).
  • [ISSN] 1399-0004
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 3.4.- / Proprotein Convertases; EC 3.4.21.- / PCSK9 protein, human; EC 3.4.21.- / Serine Endopeptidases
  • [Number-of-references] 88
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27. Schlenke TA, McKean KA: A role for alcohol dehydrogenase in the Drosophila immune response? Insect Mol Biol; 2005 Apr;14(2):175-8
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  • The levels of several proteins, including alcohol dehydrogenase (ADH), increased in LPS-treated flies and were labelled as immune response proteins.
  • While ADH activity increased in larvae receiving 1% ethanol, it was not increased after LPS injection.
  • These results suggest that ADH plays no role in the Drosophila immune response, and that other proteins identified in the previous study may instead mediate ethanol tolerance in flies and other organisms.

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  • (PMID = 15796750.001).
  • [ISSN] 0962-1075
  • [Journal-full-title] Insect molecular biology
  • [ISO-abbreviation] Insect Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / F32 GM067504
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Insect Proteins; 0 / Lipopolysaccharides; 0U46U6E8UK / NAD; 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase
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28. van Bodegom PM, Sorrell BK, Oosthoek A, Bakker C, Aerts R: Separating the effects of partial submergence and soil oxygen demand on plant physiology. Ecology; 2008 Jan;89(1):193-204
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  • Increased SOD increased root oxygen deprivation, as indicated by either raised porosity or increased alcohol dehydrogenase (ADH) activity in roots of flood-intolerant species (Calamagrostis epigejos and Carex arenaria).
  • In contrast, the most flood-tolerant species (Juncus subnodulosus and Typha latifolia) were unaffected by any treatment and maintained high internal oxygen concentrations at the shoot : root junction and low root ADH activity in all treatments.

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  • (PMID = 18376561.001).
  • [ISSN] 0012-9658
  • [Journal-full-title] Ecology
  • [ISO-abbreviation] Ecology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Soil; 059QF0KO0R / Water; EC 1.1.1.1 / Alcohol Dehydrogenase; S88TT14065 / Oxygen
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29. Hameed O, Ghali VS, Tartter PI, Mizrachi H: Immunohistochemical staining for cyclin D1 and Ki-67 aids in the stratification of atypical ductal hyperplasia diagnosed on breast core biopsy. Am J Clin Pathol; 2005 Dec;124(6):862-72
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  • [Title] Immunohistochemical staining for cyclin D1 and Ki-67 aids in the stratification of atypical ductal hyperplasia diagnosed on breast core biopsy.
  • A diagnosis of atypical ductal hyperplasia (ADH) after breast core biopsy usually is followed by an excisional biopsy to exclude the presence of a more significant lesion.
  • To determine whether the immunohistochemical expression of cyclin D1 (CyD1) and Ki-67 can aid in case stratification for the likelihood of finding ductal carcinoma in situ (DCIS) on subsequent excision, we immunohistochemically stained 21 consecutive ADH cases diagnosed by core biopsy, and proliferation indices (PIs) were calculated for each case.
  • The number of cells with CCND1 amplification was higher in cases with DCIS or ADH on subsequent excision.
  • Immunostaining for CyD1 and Ki-67 might help stratify cases of ADH on core biopsy and identify patients unlikely to have DCIS found on excision.
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Female. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Immunohistochemistry. In Situ Hybridization, Fluorescence. Middle Aged

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  • (PMID = 16416735.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 136601-57-5 / Cyclin D1
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30. Terry MB, Gammon MD, Zhang FF, Vaughan TL, Chow WH, Risch HA, Schoenberg JB, Mayne ST, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF Jr, Santella RM: Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas. Cancer Causes Control; 2007 Nov;18(9):1039-46
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  • RESULTS: Individuals homozygous for ADH ( 3 ) (1-1) had a higher risk of each tumor type compared to individuals who had ADH ( 3 ) (2-2) or ADH ( 3 ) (1-2) genotype (OR = 1.7, 95% CI = 1.0-2.9 for esophageal and gastric cardia adenocarcinomas; OR = 1.7, 95% CI = 0.7-4.3 for esophageal squamous cell carcinoma; and OR = 2.8, 95% CI = 1.5-5.1 for non-cardia gastric cancer).
  • The elevation in risk from homozygosity of the ADH ( 3 ) (1) allele was seen in drinkers and nondrinkers, although the risk estimate was only significant for drinkers, particularly of liquor.

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  • (PMID = 17665311.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01-CA57923; United States / NCI NIH HHS / CA / U01-CA57983; United States / NCI NIH HHS / CN / N01-CN05230; United States / NCI NIH HHS / CA / U01-CA57949; United States / NCI NIH HHS / CP / N02-CP40501; United States / NIEHS NIH HHS / ES / P30-ES09089; United States / NIEHS NIH HHS / ES / P30-ES10126; United States / NIEHS NIH HHS / ES / P30 ES009089
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase
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31. Macgregor S, Lind PA, Bucholz KK, Hansell NK, Madden PA, Richter MM, Montgomery GW, Martin NG, Heath AC, Whitfield JB: Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet; 2009 Feb 1;18(3):580-93
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  • [Title] Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
  • Alcohol dependence (AD) is a complex disorder with environmental and genetic origins.
  • This study tested for associations between nine polymorphisms in ALDH2 and 41 in the seven ADH genes, and alcohol-related flushing, alcohol use and dependence symptom scores in 4597 Australian twins.

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  • (PMID = 18996923.001).
  • [ISSN] 1460-2083
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / AA13320; United States / NIAAA NIH HHS / AA / AA13321; United States / NIAAA NIH HHS / AA / AA013326; United States / NIAAA NIH HHS / AA / AA07728; United States / NIAAA NIH HHS / AA / AA11998; United States / NIAAA NIH HHS / AA / AA014041; United States / NIAAA NIH HHS / AA / AA07535
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / ALDH2 protein, human; EC 1.2.1.3 / Aldehyde Dehydrogenase
  • [Other-IDs] NLM/ PMC2722191
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32. Haris A, Demeter P, Tóth I, Polner K: [Severe hyponatremia and comatose state during colonoscopy preparation]. Orv Hetil; 2010 May 16;151(20):828-31
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  • Hyponatremia was likely induced by stress provoked ADH secretion, due to the patients' fear for bowel cleansing and colonoscopy, and by large fluid intake consumed as "misunderstanding" of the instructions.
  • [MeSH-major] Colonoscopy. Coma / etiology. Drinking. Hyponatremia / etiology. Inappropriate ADH Syndrome / etiology

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  • (PMID = 20442054.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Laxatives; 0 / Phosphates; 9NEZ333N27 / Sodium; RWP5GA015D / Potassium; SE337SVY37 / sodium phosphate
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33. Ghosh S, Bierut LJ, Porjesz B, Edenberg HJ, Dick D, Goate A, Hesselbrock V, Nurnberger J Jr, Foroud T, Kramer J, Rice J, Begleiter H: A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. Am J Med Genet B Neuropsychiatr Genet; 2008 Oct 5;147B(7):1301-5
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  • We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4.

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  • (PMID = 18454434.001).
  • [ISSN] 1552-485X
  • [Journal-full-title] American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • [ISO-abbreviation] Am. J. Med. Genet. B Neuropsychiatr. Genet.
  • [Language] ENG
  • [Grant] United States / FIC NIH HHS / TW / R01 TW006604; United States / FIC NIH HHS / TW / R01 TW006604-05; United States / FIC NIH HHS / TW / R01-TW-6604; United States / NIAAA NIH HHS / AA / U10AA08403
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ NIHMS203246; NLM/ PMC2879266
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34. Trivedi AH, Spiess AC, Daussmann T, Büchs J: Study on mesophilic and thermophilic alcohol dehydrogenases in gas-phase reaction. Biotechnol Prog; 2006 Mar-Apr;22(2):454-8
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  • The initial reaction rate and the thermostability of the mesophilic alcohol dehydrogenase (ADH) from Lactobacillus brevis (LBADH), and the thermophilic ADH from Thermoanaerobacter sp. (ADH T) in gas-phase reaction were compared.
  • An excellent optimal productivity of 1,000 g x L(-1) x d(-1) for LBADH and 600 g x L(-1) x d(-1)for ADH T was found at 60 degrees C, while the highest total turnover numbers with respect to the enzyme were achieved at 30 degrees C and amounted to 4.2 million for LBADH and 1.7 million for ADH T, respectively.
  • Interestingly, the ADH from the mesophilic L. brevisshowed the higher thermostability in the nonconventional medium gas phase.

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  • (PMID = 16599562.001).
  • [ISSN] 8756-7938
  • [Journal-full-title] Biotechnology progress
  • [ISO-abbreviation] Biotechnol. Prog.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzymes, Immobilized; 059QF0KO0R / Water; EC 1.1.1.1 / Alcohol Dehydrogenase
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35. Viale G: Histopathology of primary breast cancer 2005. Breast; 2005 Dec;14(6):487-92
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  • [Title] Histopathology of primary breast cancer 2005.
  • The new WHO classification of tumors of the breast highlights the morphological features of flat epithelial atypia (DIN 1A) and atypical duct hyperplasia (DIN 1B).
  • Flat epithelial atypia now encompasses lesions previously designated as clinging carcinoma (monomorphous type) and atypical columnar changes.
  • Atypical ductal hyperplasia (ADH) is characterized by the same cytological changes as low-grade DCIS, involving a very small portion of the ductal tree.
  • [MeSH-major] Breast Neoplasms / pathology

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  • (PMID = 16169223.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 25
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36. García-Otín AL, Cofán M, Junyent M, Recalde D, Cenarro A, Pocoví M, Ros E, Civeira F: Increased intestinal cholesterol absorption in autosomal dominant hypercholesterolemia and no mutations in the low-density lipoprotein receptor or apolipoprotein B genes. J Clin Endocrinol Metab; 2007 Sep;92(9):3667-73
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  • CONTEXT: Autosomal dominant hypercholesterolemia (ADH) is frequently caused by functional mutations in the low-density lipoprotein receptor (LDLR) or apolipoprotein B-100 (APOB) genes, but approximately 40% of ADH subjects disclose no such molecular defects, possibly pointing to alternative genetic mechanisms.
  • OBJECTIVE: Our objective was to test the hypothesis that increased intestinal cholesterol absorption might play a role in the lipid abnormalities of subjects with ADH without identified genetic defects.
  • STUDY SUBJECTS: A total of 52 subjects with a clinical diagnosis of ADH were examined for molecular defects in LDLR and APOB.
  • Functional LDLR mutations occurred in 31 (60%) subjects, who received a diagnosis of familial hypercholesterolemia (FH).
  • Those for whom no mutations could be identified were labeled as non-FH ADH.
  • RESULTS: Adjusted campesterol to cholesterol ratios increased in the order non-FH ADH more than FH more than controls more than FCH, with mean values (95% confidence interval) in 10(2) mmol/mol cholesterol of 505 (424-600), 397 (345-458), 335 (294-382), and 284 (247-328), respectively.
  • Thus, cholesterol absorption was lowest in FCH and highest in non-FH ADH.
  • CONCLUSIONS: Increased intestinal cholesterol absorption may partially explain the high cholesterol levels of non-FH ADH subjects.
  • Serum noncholesterol sterols are a useful tool for the differential diagnosis of genetic hypercholesterolemias, especially FCH and ADH unrelated to LDLR or APOB defects.

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  • (PMID = 17566095.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins B; 0 / Receptors, LDL; 0 / Sterols; 97C5T2UQ7J / Cholesterol
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37. Campos FM, Liarte DB, Mortara RA, Romanha AJ, Murta SM: Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi. Acta Trop; 2009 Jul;111(1):56-63
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  • Alcohol dehydrogenases (ADH) are a class of oxidoreductases that catalyse the reversible oxidation of ethanol to acetaldehyde.

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  • (PMID = 19426664.001).
  • [ISSN] 1873-6254
  • [Journal-full-title] Acta tropica
  • [ISO-abbreviation] Acta Trop.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Protozoan; 0 / Nitroimidazoles; 0 / Protozoan Proteins; 0 / RNA, Messenger; 0 / RNA, Protozoan; 0 / Trypanocidal Agents; EC 1.1.1.1 / Alcohol Dehydrogenase; M84I3K7C2O / Nifurtimox; YC42NRJ1ZD / benzonidazole
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38. Trabold R, Krieg S, Schöller K, Plesnila N: Role of vasopressin V(1a) and V2 receptors for the development of secondary brain damage after traumatic brain injury in mice. J Neurotrauma; 2008 Dec;25(12):1459-65
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  • The goal of the current study was to investigate the role of arginine vasopressin (AVP), also known as antidiuretic hormone (ADH), an important regulator of tissue water homeostasis, for the formation of post-traumatic brain edema, intracranial pressure (ICP), brain damage, and functional deficits following brain trauma.

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  • (PMID = 19118456.001).
  • [ISSN] 0897-7151
  • [Journal-full-title] Journal of neurotrauma
  • [ISO-abbreviation] J. Neurotrauma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antidiuretic Hormone Receptor Antagonists; 0 / Receptors, Vasopressin; 113-79-1 / Arginine Vasopressin
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39. Zhang W, SLi, Visocchi M, Jiang J, Wang X: Natriuretic peptides, antidiuretic hormone and hyponatraemia after acute craniocerebral injury. J Int Med Res; 2008 Jul-Aug;36(4):648-55
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  • We measured blood concentrations of natriuretic peptides, antidiuretic hormone (ADH), and endogenous digitalis-like substance (EDLS), blood and urine sodium concentrations, and the plasma and urine osmolality in 68 patients with ACI and 24 healthy control subjects.
  • Blood concentrations of EDLS and ADH in hyponatraemic ACI patients were significantly higher compared with normonatraemic ACI patients and control subjects.

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  • (PMID = 18652759.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cardenolides; 0 / Natriuretic Peptides; 0 / Saponins; 0 / digoxin-like factors; 11000-17-2 / Vasopressins
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40. Montane-Jaime K, Moore S, Shafe S, Joseph R, Crooks H, Carr L, Ehlers CL: ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago. Alcohol; 2006 Jun;39(2):81-6
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  • Variants in alcohol dehydrogenase (ADH) genes differ between ethnic groups and have, in some studies, been found to be associated with alcohol dependence and alcoholic liver disease.
  • This study sought to determine whether an association exists between ADH (ADH1C previously ADH3, ADH1B*2 previously ADH2*2) genotypes, alcohol dependence, drinking history, and liver function tests in the two major ethnic groups of Trinidad and Tobago (TT).

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  • (PMID = 17134660.001).
  • [ISSN] 0741-8329
  • [Journal-full-title] Alcohol (Fayetteville, N.Y.)
  • [ISO-abbreviation] Alcohol
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / R21 AA014370; United States / PHS HHS / / 014370; United States / PHS HHS / / 06420; United States / NIAAA NIH HHS / AA / AA07611
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 2.3.2.2 / gamma-Glutamyltransferase; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase; EC 3.1.3.1 / Alkaline Phosphatase
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41. Alberti C: [Paraneoplastic syndromes associated with urogenital tumours: an up-to-date review]. G Chir; 2008 Oct;29(10):437-48
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  • On the basis of an up-to-date review of the literature, this article discusses pathogenetic mechanisms, diagnostic features and essential therapeutic measures concerning the syndromes of inappropriate ACTH/CRH, PTHrp, TRH/TSH, ADH and MSH secretion.

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  • (PMID = 18947470.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Cytokines; 0 / Intercellular Signaling Peptides and Proteins; 0 / Peptide Hormones; 333DO1RDJY / Serotonin
  • [Number-of-references] 89
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42. Theman TA, Collins MT, Dempster DW, Zhou H, Reynolds JC, Brahim JS, Roschger P, Klaushofer K, Winer KK: PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation. J Bone Miner Res; 2009 May;24(5):964-73
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  • Autosomal dominant hypocalcemia (ADH) is an inherited form of hypoparathyroidism caused by activating mutations in the calcium-sensing receptor (CaR).
  • The patient is a 20-yr-old female with ADH treated with PTH continuously since 6 yr and 2 mo of age.
  • Her data were compared with one age-, sex-, and length of hypoparathyroidism-matched control not on PTH and two sex-matched ADH controls before and after 1 yr of PTH.
  • Cancellous bone volume was dramatically elevated in the patient and in ADH controls after 1 yr of PTH.
  • BMD distribution (BMDD) by qBEI of the patient and ADH controls was strikingly shifted toward lower mineralization compared with the non-ADH control.
  • Moreover, the ADH controls exhibited a further reduction in mineralization after 1 yr of PTH.
  • In conclusion, long-term PTH replacement in a child with ADH was not unsafe, increased bone mass without negatively impacting mineralization, and improved serum mineral control but did not prevent nephrocalcinosis.

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  • (PMID = 19063686.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Receptors, Calcium-Sensing
  • [Other-IDs] NLM/ PMC2672210
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43. Chen HJ, Tian H, Edenberg HJ: Natural haplotypes in the regulatory sequences affect human alcohol dehydrogenase 1C (ADH1C) gene expression. Hum Mutat; 2005 Feb;25(2):150-5
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  • Human alcohol dehydrogenases (ADHs) play important roles in metabolizing alcohol, and several lines of evidence suggest that variations in ADH genes affect the risk for alcoholism.
  • Differences in regulatory sequences could affect the expression of ADH genes and thereby modify the risk for alcoholism.

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15643610.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Databank-accession-numbers] OMIM/ 103730
  • [Grant] United States / NIAAA NIH HHS / AA / R37-AA06460
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase
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44. Yu HS, Oyama T, Isse T, Kitagawa K, Pham TT, Tanaka M, Kawamoto T: Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. Chem Biol Interact; 2010 Dec 5;188(3):367-75
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  • Ingested ethanol is mainly oxidized by the enzymes alcohol dehydrogenase (ADH), cytochrome P-450 2E1 (CYP2E1), and catalase to form acetaldehyde, which is subsequently oxidized by aldehyde dehydrogenase 2 (ALDH2) to produce acetate.
  • ADH1B*2 allele (ADH1B, one of the enzyme in ADH family) is commonly observed in Asian population, has much higher enzymatic activity than ADH1B*1 allele.

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20813101.001).
  • [ISSN] 1872-7786
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Alcohols; 0 / DNA Adducts; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / Aldehyde Dehydrogenase; GO1N1ZPR3B / Acetaldehyde
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45. Belokon' MM, Belokon' IuS, Politov DV, Altukhov IuP: [Allozyme polymorphism of Swiss stone pine Pinus cembra L. in mountainous populations of the Alps and the Eastern Carpathians]. Genetika; 2005 Nov;41(11):1538-51
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  • The allele frequencies of 30 isozyme loci, coding for enzymes ADH, FDH, FEST, GDH, GOT, IDH, LAP, MNR, MDH, PEPCA, 6PGD, PGI, PGM, SDH, SKDH, SOD, were analyzed using cluster analysis and methods of principal components.
  • The main contribution to these differences were made by loci Adh-1, Adh-2, Fest-2, Lap-3, Mdh-4, and Sod-4.

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  • (PMID = 16358721.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Enzymes; 0 / Plant Proteins
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46. Charlot A, Heyraud A, Guenot P, Rinaudo M, Auzély-Velty R: Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules. Biomacromolecules; 2006 Mar;7(3):907-13
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  • This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a reductive amination-type reaction.

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  • (PMID = 16529430.001).
  • [ISSN] 1525-7797
  • [Journal-full-title] Biomacromolecules
  • [ISO-abbreviation] Biomacromolecules
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetates; 0 / Polymers; 0 / beta-Cyclodextrins; 9004-61-9 / Hyaluronic Acid; JV039JZZ3A / betadex; PJY633525U / Adamantane; WK2XYI10QM / Ibuprofen
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47. Defilippi BG, Dandekar AM, Kader AA: Relationship of ethylene biosynthesis to volatile production, related enzymes, and precursor availability in apple peel and flesh tissues. J Agric Food Chem; 2005 Apr 20;53(8):3133-41
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  • The study was focused at the level of the aroma volatile-related enzymes, including alcohol acyltransferase (AAT), alcohol dehydrogenase (ADH), and lipoxygenase (LOX) and at the level of amino acids and fatty acids as aroma volatile precursors in peel and flesh tissues.
  • Contrarily, ADH and LOX seem to be independent of ethylene modulation.

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  • (PMID = 15826070.001).
  • [ISSN] 0021-8561
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Ethylenes; 0 / Fatty Acids; 04Y7590D77 / Isoleucine; 91GW059KN7 / ethylene; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.13.11.12 / Lipoxygenase; EC 2.3.- / Acyltransferases
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48. Das S, Devi PG, Pal S, Dasgupta D: Effect of complex formation between Zn2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase. J Biol Inorg Chem; 2005 Jan;10(1):25-32
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  • In the second part, we have examined the effect of the association of Zn(2+) with MTR on the enzymatic activity of a typical zinc(II)-dependent alcohol dehydrogenase (ADH) from yeast.
  • We also observe a negative effect for the preincubation of ADH with MTR upon the enzymatic activity.

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  • [ISO-abbreviation] J. Biol. Inorg. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
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49. Zhang H, Cui W, Wen J, Blankenship RE, Gross ML: Native electrospray and electron-capture dissociation in FTICR mass spectrometry provide top-down sequencing of a protein component in an intact protein assembly. J Am Soc Mass Spectrom; 2010 Dec;21(12):1966-8
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  • The intact yeast alcohol dehydrogenase (ADH) tetramer of 147 kDa was introduced into a FTICR mass spectrometer by native electrospray.
  • The results are in accord with the crystal structure of yeast ADH, which shows that the C-terminus is buried at the assembly interface, whereas the N-terminus is exposed, allowing ECD to occur.

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  • [Copyright] Copyright © 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20843701.001).
  • [ISSN] 1879-1123
  • [Journal-full-title] Journal of the American Society for Mass Spectrometry
  • [ISO-abbreviation] J. Am. Soc. Mass Spectrom.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / S10 RR025101-01; United States / NIGMS NIH HHS / GM / P41 GM103422; United States / NCRR NIH HHS / RR / S10 RR025101; United States / PHS HHS / / NCRR 1S10 025101; United States / NCRR NIH HHS / RR / P41 RR000954; United States / NCRR NIH HHS / RR / P41RR000954
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fungal Proteins; 0 / Protein Subunits; EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ NIHMS236365; NLM/ PMC2991543
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50. Gao LB, Wang JZ, Zeng S: [Cloning, expression and the application of human, rat alcohol dehydrogenase and aldo-keto reductase]. Yao Xue Xue Bao; 2009 Jul;44(7):778-84
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  • This study is aimed to clone and express human, rat alcohol dehydrogenase (ADH) and aldo-keto reductase.
  • MA enantiomers were incubated with rat, human ADH and phenylglyoxylic acid (PGA) with AKR1A1, respectively.

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  • (PMID = 19806920.001).
  • [ISSN] 0513-4870
  • [Journal-full-title] Yao xue xue bao = Acta pharmaceutica Sinica
  • [ISO-abbreviation] Yao Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Recombinant Proteins; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.184 / carbonyl reductase (NADPH); EC 1.1.1.21 / Aldehyde Reductase
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51. Yamashita H, Ishimaru M, Yamaguchi H, Yamauchi H, Sugiura A, Kitayama J, Nagawa H: Massive postoperative polyuria following total gastrectomy for gastric cancer. J Anesth; 2006;20(1):36-9
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  • Several administrations of an antidiuretic hormone (ADH) analogue were ineffective in reducing urine output, suggesting a possible relationship of the massive polyuria to nephrogenic diabetes insipidus.

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  • [ISSN] 0913-8668
  • [Journal-full-title] Journal of anesthesia
  • [ISO-abbreviation] J Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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52. O'Malley FP: Lobular neoplasia: morphology, biological potential and management in core biopsies. Mod Pathol; 2010 May;23 Suppl 2:S14-25
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  • [Title] Lobular neoplasia: morphology, biological potential and management in core biopsies.
  • Lobular neoplasia has been traditionally recognized as a marker of increased risk for subsequent breast carcinoma development; however, molecular studies suggest that it also behaves in a non-obligate precursor manner.
  • Recently, several variants of lobular carcinoma in situ (LCIS), most notably pleomorphic LCIS, have been recognized and these can be difficult to differentiate from ductal carcinoma in situ.
  • Application of strict diagnostic criteria and the judicial use of immunohistochemistry, particularly E-cadherin, can be helpful in this differential diagnosis.
  • Another challenging issue is the management of lobular neoplasia when diagnosed on core biopsy.
  • The goals of this review are (1) to describe the morphological criteria used to diagnose the spectrum of lobular neoplastic lesions, including atypical lobular hyperplasia, LCIS and variants of LCIS;.
  • (2) to discuss the data exploring the biological potential of lobular neoplasia from an epidemiological and molecular viewpoint; and (3) to outline the recommendations for management of lobular neoplasia when encountered in core biopsies.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Lobular / pathology
  • [MeSH-minor] Biopsy. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / therapy. Diagnosis, Differential. Female. Humans. Prognosis

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  • (PMID = 20436498.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 97
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53. Lu RB, Ko HC, Lee JF, Lin WW, Huang SY, Wang TJ, Wu YS, Lu TE, Chou YH: No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. Alcohol Clin Exp Res; 2005 Dec;29(12):2101-7
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  • Most previous studies, however, have failed to separate the effects of antisocial personality disorder from those of alcoholism because of their high comorbidity.
  • To understand the relationship among alcoholism, antisocial personality disorder, and the protective effects of ADH and ALDH, it is necessary to recruit individuals with antisocial personality disorder but without alcoholism.
  • METHODS: We recruited 579 Han Chinese individuals in Taiwan, intending to examine the alcoholism-protection effects of different ADH1B and ALDH2 genotypes with or without antisocial personality disorder.
  • [MeSH-major] Alcohol Dehydrogenase / genetics. Alcoholism / epidemiology. Alcoholism / genetics. Antisocial Personality Disorder / epidemiology. Antisocial Personality Disorder / genetics

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  • (PMID = 16385179.001).
  • [ISSN] 0145-6008
  • [Journal-full-title] Alcoholism, clinical and experimental research
  • [ISO-abbreviation] Alcohol. Clin. Exp. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA; EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / Aldehyde Dehydrogenase
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54. Yalcin-Cakmakli G, Karli Oguz K, Shorbagi A, Funda Bas D, Ergan-Arsava B, Kunt M, Topcuoglu MA: Hyponatremic encephalopathy after excessive water ingestion prior to pelvic ultrasound: neuroimaging findings. Intern Med; 2010;49(16):1807-11
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  • In addition to the first illustration of multimodality MR imaging features of water-intoxication, these two cases also highlight the need for standardized practice on the quantity of water intake recommended to distend the bladder for pelvic ultrasound, especially in patients at risk for serum inappropriate ADH syndrome-related hyponatremia.
  • [MeSH-major] Brain Edema / diagnosis. Hyponatremia / diagnosis. Pelvis / ultrasonography. Water Intoxication / diagnosis

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  • (PMID = 20720364.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Lee SM, Alam R, Ho CJ, Kim JH, Kang CW, Park JH, Lee MS: Involvement of p42/44 MAPK in the effects of ethanol on secretion of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-1 in primary cultured rat hepatocytes. Int J Neurosci; 2007 Feb;117(2):187-201
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  • In addition, inhibition of p42/44 MAPK activity by ethanol occurs via the activity of ADH.

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  • (PMID = 17365107.001).
  • [ISSN] 0020-7454
  • [Journal-full-title] The International journal of neuroscience
  • [ISO-abbreviation] Int. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Enzyme Inhibitors; 0 / Insulin-Like Growth Factor Binding Protein 1; 3K9958V90M / Ethanol; 67763-96-6 / Insulin-Like Growth Factor I; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
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56. Chiang CP, Wu CW, Lee SP, Chung CC, Wang CW, Lee SL, Nieh S, Yin SJ: Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury. Alcohol Clin Exp Res; 2009 Jun;33(6):1059-68
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  • BACKGROUND: Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are major enzymes responsible for metabolism of ethanol.
  • The goal of this study was to determine the functional expressions and cellular localization of ADH and ALDH families in human pancreas.
  • The isozyme expression patterns of ADH/ALDH were identified by isoelectric focusing, and the activities were assayed spectrophotometrically.
  • The protein contents of ADH/ALDH isozymes were determined by immunoblotting, and the cellular localizations were detected by immunohistochemistry and histochemistry.

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  • (PMID = 19382905.001).
  • [ISSN] 1530-0277
  • [Journal-full-title] Alcoholism, clinical and experimental research
  • [ISO-abbreviation] Alcohol. Clin. Exp. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Isoenzymes; 3K9958V90M / Ethanol; EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / ALDH2 protein, human; EC 1.2.1.3 / Aldehyde Dehydrogenase
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57. Yeom J, Bhang SH, Kim BS, Seo MS, Hwang EJ, Cho IH, Park JK, Hahn SK: Effect of cross-linking reagents for hyaluronic acid hydrogel dermal fillers on tissue augmentation and regeneration. Bioconjug Chem; 2010 Feb 17;21(2):240-7
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  • Five kinds of samples, a normal control, a negative control, a positive control of Restylane, adipic acid dihydrazide grafted HA (HA-ADH) hydrogels, and HA-HMDA hydrogels, were subcutaneously injected to wrinkled model mice.

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  • (PMID = 20078098.001).
  • [ISSN] 1520-4812
  • [Journal-full-title] Bioconjugate chemistry
  • [ISO-abbreviation] Bioconjug. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Cross-Linking Reagents; 0 / Diamines; 0 / Hydrogels; 9004-61-9 / Hyaluronic Acid; 9007-34-5 / Collagen; ZRA5J5B2QW / 1,6-diaminohexane
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58. Weinberg IN: Applications for positron emission mammography. Phys Med; 2006;21 Suppl 1:132-7
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  • High resolution positron emission mammography (PEM) can address the current clinical needs of breast cancer patients and the requirements for future translational work.
  • Combining the quantitative capabilities of positron emission tomography (PET) with millimeter resolution, PEM can image the earliest in situ forms of breast cancer as well as putative cancer precursor lesions (e.g., atypical ductal hyperplasia) whose behavior is important for prevention studies.
  • The high overall accuracy of PEM (i.e., both specificity and sensitivity) is an unusual and welcome development in the history of breast imaging.
  • With this high accuracy, and continued technical innovation to reduce radiation dose, PEM may someday replace X-ray mammography as a first line approach to breast cancer detection.

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  • (PMID = 17646015.001).
  • [ISSN] 1120-1797
  • [Journal-full-title] Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
  • [ISO-abbreviation] Phys Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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59. Visscher DW, Pankratz VS, Santisteban M, Reynolds C, Ristimäki A, Vierkant RA, Lingle WL, Frost MH, Hartmann LC: Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. J Natl Cancer Inst; 2008 Mar 19;100(6):421-7
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  • [Title] Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer.
  • COX-2 is overexpressed in invasive and in situ breast cancers.
  • Atypical hyperplasia in breast tissue, although benign, is associated with a high risk of breast cancer.
  • We investigated whether COX-2 overexpression in atypical hyperplasia is associated with the risk of subsequent breast cancer.
  • Risk factor information and follow-up for breast cancer events were obtained via a study questionnaire and the medical records.
  • RESULTS: Forty-one (17%) of the 235 women developed breast cancer during a median follow-up of 15 years.
  • The risk for developing breast cancer, relative to a control population (the Iowa Surveillance, Epidemiology, and End Results registry), increased with increasing COX-2 expression (relative risk [RR] = 2.63, 95% confidence interval [CI] = 1.56 to 4.15, for those with negative or weak COX-2 expression; RR = 3.56, 95% CI = 1.94 to 5.97, for those with moderate expression; and RR = 5.66, 95% CI = 2.59 to 10.75, for those with strong expression; P = .07).
  • Overexpression of COX-2 was statistically significantly associated with the type of atypia (lobular vs ductal, P < .001), number of foci of atypia in the biopsy (P = .02), and older age at time of biopsy (>45 years, P = .01).
  • CONCLUSIONS: COX-2 appears to be a biomarker that further stratifies breast cancer risk among women with atypia and may be a relevant target for chemoprevention strategies.

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  • (PMID = 18334709.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA136393; United States / NCI NIH HHS / CA / R01 CA46332
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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60. Penco S, Rizzo S, Bozzini AC, Latronico A, Menna S, Cassano E, Bellomi M: Stereotactic vacuum-assisted breast biopsy is not a therapeutic procedure even when all mammographically found calcifications are removed: analysis of 4,086 procedures. AJR Am J Roentgenol; 2010 Nov;195(5):1255-60
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  • [Title] Stereotactic vacuum-assisted breast biopsy is not a therapeutic procedure even when all mammographically found calcifications are removed: analysis of 4,086 procedures.
  • MATERIALS AND METHODS: We retrospectively reviewed 4,086 stereotactic vacuum-assisted breast biopsy (VABB) procedures for microcalcifications and histologic findings to determine the frequency of malignancy, histologic underestimation, and complete removal of cancer.
  • RESULTS: No residual microcalcifications on postbiopsy mammograms were seen in 1,594 of 4,047 (39.4%) procedures successfully completed: 351 of 1,594 lesions were malignant, 1,109 benign and 134 atypical.
  • The atypical ductal hyperplasia underestimation rate was 6.6% when the mammography target was completely removed and 38.7% when the target was only sampled.
  • [MeSH-major] Biopsy / methods. Breast Diseases / pathology. Breast Diseases / surgery. Calcinosis / pathology. Calcinosis / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms / surgery. Chi-Square Distribution. Humans. Mammography. Middle Aged. Retrospective Studies. Vacuum

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  • (PMID = 20966337.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Dendorfer U, Mann J: [Drug-related disorders of water and electrolyte metabolism]. Internist (Berl); 2006 Nov;47(11):1121-2, 1124-6, 8
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  • Drug-induced disorders of Na+ concentration may usually be attributed to altered antidiuretic hormone (ADH) effects, either as diabetes insipidus or as the syndrome of inappropriate ADH secretion.

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  • (PMID = 16988802.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Antidiuretic Agents; 0 / Antihypertensive Agents; 0 / Gonadal Steroid Hormones
  • [Number-of-references] 24
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62. Chen YY, DeVries S, Anderson J, Lessing J, Swain R, Chin K, Shim V, Esserman LJ, Waldman FM, Hwang ES: Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ. BMC Cancer; 2009 Aug 18;9:285
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  • [Title] Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.
  • BACKGROUND: Endocrine therapy is commonly recommended in the adjuvant setting for patients as treatment for ductal carcinoma in situ (DCIS).
  • Following treatment, predominant morphologic changes included increased multinucleated histiocytes and degenerated cells, decreased duct extension, and prominent periductal fibrosis.
  • Two postmenopausal patients had ADH only with no residual DCIS at excision.
  • [MeSH-major] Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Estrogen Antagonists / therapeutic use. Hormone Replacement Therapy. Receptors, Estrogen / metabolism. Tamoxifen / therapeutic use
  • [MeSH-minor] Adult. Aged. Carcinoma, Ductal. Cohort Studies. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Nitriles / therapeutic use. Triazoles / therapeutic use

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  • (PMID = 19689789.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00290745
  • [Grant] United States / NCI NIH HHS / CA / K23CA097181; United States / NCI NIH HHS / CA / P50 CA58207
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 0 / Nitriles; 0 / Receptors, Estrogen; 0 / Triazoles; 094ZI81Y45 / Tamoxifen; 7LKK855W8I / letrozole
  • [Other-IDs] NLM/ PMC2744704
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63. Zagouri F, Sergentanis TN, Nonni A, Koulocheri D, Fotou M, Panopoulou E, Panou M, Fotiadis C, Bramis J, Zografos GC: Vacuum-assisted breast biopsy: the value and limitations of cores with microcalcifications. Pathol Res Pract; 2007;203(8):563-6
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  • [Title] Vacuum-assisted breast biopsy: the value and limitations of cores with microcalcifications.
  • The aim of this study was to assess cores with microcalcifications (CM) and without microcalcifications (CWM) obtained from vacuum-assisted breast biopsy (VABB).
  • The study included 12 atypical ductal hyperplasias (ADH), 37 ductal carcinomas in situ (DCIS), and seven invasive ductal carcinomas (IDC) diagnosed by VABB (11G) on the Fischer's table.
  • CWM failed to make the diagnosis in 8.3% and 35.1% of ADH and DCIS, respectively.
  • In 28.6% of IDC, diagnosis was made through CWM.
  • The underestimation rate was 8.3% in ADH, and 10.8% in DCIS.
  • CMs are superior in DCIS/ADH diagnosis.
  • However, CWM may be valuable for the diagnosis of the invasive component.
  • [MeSH-major] Biopsy / methods. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Calcinosis / pathology. Calcinosis / surgery

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  • (PMID = 17611039.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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64. Di F, Wong NL: [Fine needle aspiration cytology diagnosis of ductal lesions of breast]. Zhonghua Bing Li Xue Za Zhi; 2010 Jul;39(7):467-72
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  • [Title] [Fine needle aspiration cytology diagnosis of ductal lesions of breast].
  • OBJECTIVE: To find out the most effective and combined cytomorphologic criteria trying to set up an effective diagnostic model for breast ductal lesion in fine needle aspiration cytology (FNAC).
  • METHODS: A total of 400 breast FNAC cases were collected with follow-up information of more than six years.
  • A retrospective analysis including 104 non-proliferative breast diseases, 163 proliferative breast diseases and 133 carcinomas basing on the diagnostic results of surgical biopsies.
  • Multiple step-wise logistic regression (SPSS) and classification tree model (SAS) were performed to determine the significant and combined variables predictive for the diagnosis of non-proliferative lesion, proliferative breast diseases and carcinoma, respectively. RESULTS:.
  • If the criterion of myoepithelial cells intermingling within epithelial cluster was not found in the sample and associating with presence of small epithelial cell clusters, cytoplasmic vacuoles and figures of "progressive intussusception" of cells, mostly (81.3%), it would be considered as a case of carcinoma. (2) Among 267 benign non-proliferative and proliferative breast diseases studied, both the multiple step-wise logistic regression and classification tree model, presence of irregular intercellular spaces within the epithelial clusters (P = 0.001), loose epithelial clusters (P < 0.05) and hyperchromasia (P < 0.1) were selected as the significant differential diagnostic criteria for the proliferative lesion.
  • Presence of a single variable of irregular intercellular spaces within the epithelial clusters had the possibility of a benign lesion diagnosis up to 70.1% in all the proliferative breast disease cases collected in this series.
  • The possibility of a proliferative breast disease would be reached to 87.5%, if both the criteria of irregular intercellular spaces and loosely arranged epithelial cell clusters were counted in combination. (3) The histological results of 35 lesions with atypical cytological features in FNAC specimens were predominantly a proliferative lesion of the breast (26 cases), and most of them were fibroadenoma with ductal hyperplasia.
  • Occasionally, there might be a few benign cases complicating with lesions of atypical hyperplasia or carcinoma.
  • CONCLUSIONS: In breast FNAC diagnosis, a combined evaluation of significant variables and the amount of the variable involved are effective for the differential diagnosis between benign/malignant and non-proliferative/proliferative lesions.
  • Lesion accompanying with atypical cellular features should avoid to be overdiagnosed as carcinoma, and biopsy for a histological diagnosis is indicative.
  • [MeSH-major] Breast / pathology. Breast Diseases / diagnosis. Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Fibroadenoma / diagnosis. Precancerous Conditions / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Cytodiagnosis. Diagnosis, Differential. Epithelial Cells / pathology. Female. Follow-Up Studies. Humans. Hyperplasia. Retrospective Studies

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  • (PMID = 21055176.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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65. Kristoffersen L, Skuterud B, Larssen BR, Skurtveit S, Smith-Kielland A: Fast quantification of ethanol in whole blood specimens by the enzymatic alcohol dehydrogenase method. Optimization by experimental design. J Anal Toxicol; 2005 Jan-Feb;29(1):66-70
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  • Alcohol dehydrogenase (ADH) oxidizes ethanol to acetaldehyde using the coenzyme nicotinamide adenine dinucleotide (NAD), which is concurrently reduced to form NADH.
  • Method development was performed with the aid of factorial design, varying pH, and concentrations of NAD+ and ADH.

  • Hazardous Substances Data Bank. ETHANOL .
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  • (PMID = 15808017.001).
  • [ISSN] 0146-4760
  • [Journal-full-title] Journal of analytical toxicology
  • [ISO-abbreviation] J Anal Toxicol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase
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66. Guth AA, Shanker BA, Roses DF, Axelrod D, Singh B, Toth H, Shapiro RL, Hiotis K, Diflo T, Cangiarella JF: A decade of change: an institutional experience with breast surgery in 1995 and 2005. Breast Cancer (Auckl); 2008;1:51-5
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  • [Title] A decade of change: an institutional experience with breast surgery in 1995 and 2005.
  • INTRODUCTION: With the adoption of routine screening mammography, breast cancers are being diagnosed at earlier stages, with DCIS now accouting for 22.5% of all newly diagnosed breast cancers.
  • This has been attributed to both increased breast cancer awareness and improvements in breast imaging techniques.
  • How have these changes, including the increased use of image-guided sampling techniques, influenced the clinical practice of breast surgery?
  • METHODS: The institutional pathology database was queried for all breast surgeries, including breast reconstruction, performed in 1995 and 2005.
  • ADH, and to a lesser extent, ALH, became indications for surgical excision.
  • Fewer surgical biopsies were performed for indeterminate abnormalities on breast imaging, due to the introduction of stereotactic large core biopsy.
  • While the rate of benign breast biopsies remained constant, there was a higher percentage of precancerous and DCIS cases in 2005.
  • CONCLUSIONS: While the rate of benign breast biopsies has remained constant over a recent 10-year period, fewer diagnostic surgical image-guided biopsies were performed in 2005.
  • A greater percentage of patients with breast cancer or preinvasive disease have these diagnoses determined before surgery.

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  • (PMID = 21655372.001).
  • [Journal-full-title] Breast cancer : basic and clinical research
  • [ISO-abbreviation] Breast Cancer (Auckl)
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3091402
  • [Keywords] NOTNLM ; breast cancer / breast cancer trends / breast radiology / breast surgery / sentinel nodes
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67. Balasundaram B, Harrison ST: Disruption of Brewers' yeast by hydrodynamic cavitation: Process variables and their influence on selective release. Biotechnol Bioeng; 2006 Jun 5;94(2):303-11
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  • The release profile of the enzymes studied include alpha-glucosidase (periplasmic), invertase (cell wall bound), alcohol dehydrogenase (ADH; cytoplasmic) and glucose-6-phosphate dehydrogenase (G6PDH; cytoplasmic).

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  • [Copyright] Copyright 2006 Wiley Periodicals, Inc.
  • (PMID = 16570316.001).
  • [ISSN] 0006-3592
  • [Journal-full-title] Biotechnology and bioengineering
  • [ISO-abbreviation] Biotechnol. Bioeng.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase; EC 3.2.1.- / Glycoside Hydrolases
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68. Atsumi S, Wu TY, Eckl EM, Hawkins SD, Buelter T, Liao JC: Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes. Appl Microbiol Biotechnol; 2010 Jan;85(3):651-7
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  • Here, we have compared the effect of various alcohol dehydrogenases (ADH) for the last step of the isobutanol production. E. coli has the yqhD gene which encodes a broad-range ADH.
  • The adh genes of two bacteria and one yeast were also compared in E. coli harboring the isobutanol synthesis pathway.

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  • BioCyc. gene/protein/disease-specific - yqhD .
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  • (PMID = 19609521.001).
  • [ISSN] 1432-0614
  • [Journal-full-title] Applied microbiology and biotechnology
  • [ISO-abbreviation] Appl. Microbiol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Butanols; 0 / Escherichia coli Proteins; 0 / Fungal Proteins; 0 / Recombinant Proteins; 56F9Z98TEM / isobutyl alcohol; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.21 / Aldehyde Reductase
  • [Other-IDs] NLM/ PMC2802489
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69. Collins LC: Flat Epithelial Atypia of the Breast. Surg Pathol Clin; 2009 Jun;2(2):263-72
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  • [Title] Flat Epithelial Atypia of the Breast.
  • Lesions of the breast characterized by enlarged terminal duct lobular units lined by columnar epithelial cells are being encountered increasingly in breast biopsy specimens.
  • The role of these lesions (recently designated "flat epithelial atypia" [FEA]) in breast tumor progression is still emerging.
  • FEA commonly coexists with well-developed examples of atypical ductal hyperplasia, low-grade ductal carcinoma in situ, lobular neoplasia, and tubular carcinoma.
  • These findings and those of recent genetic studies suggest that FEA is a neoplastic lesion that may represent a precursor to or the earliest morphologic manifestation of ductal carcinoma in situ.

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  • [Copyright] Copyright © 2009 Elsevier Inc. All rights reserved.
  • (PMID = 26838322.001).
  • [ISSN] 1875-9181
  • [Journal-full-title] Surgical pathology clinics
  • [ISO-abbreviation] Surg Pathol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Breast / Columnar cell / Flat epithelial atypia / Low-grade neoplasia
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70. Zografos GC, Zagouri F, Sergentanis TN, Koulocheri D, Nonni A, Oikonomou V, Domeyer P, Kotsani M, Fotiadis C, Bramis J: Is zero underestimation feasible? Extended Vacuum-Assisted Breast Biopsy in solid lesions - a blind study. World J Surg Oncol; 2007;5:53
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  • [Title] Is zero underestimation feasible? Extended Vacuum-Assisted Breast Biopsy in solid lesions - a blind study.
  • BACKGROUND: Vacuum-Assisted Breast Biopsy (VABB) is effective for the preoperative diagnosis of non-palpable mammographic solid lesions.
  • The main disadvantage is underestimation, which might render the management of atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) difficult.
  • PATIENTS AND METHODS: A total of 107 women with non-palpable mammographic breast solid tumors BI-RADS 3 and 4 underwent VABB with 11G, on the stereotactic Fischer's table.
  • A preoperative diagnosis was established.
  • Women with a preoperative diagnosis of precursor/preinvasive/invasive lesion underwent open surgery.
  • A second pathologist, blind to the preoperative results and to the protocol made the postoperative diagnosis.
  • In the extended protocol, the postoperative diagnosis was less severe than the preoperative in 55.5% of cases (55.5% vs. 0%, p = 0.029), and preoperative ADH was totally removed.
  • This might possibly point to a modified management of ADH lesions.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Precancerous Conditions / pathology

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  • (PMID = 17501997.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1885798
  • [General-notes] NLM/ Original DateCompleted: 20070813
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71. Yang Z, Lu CD: Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa. J Bacteriol; 2007 Jun;189(11):3945-53
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  • While most of the genes involved in arginine uptake, regulation, and metabolism have been identified as members of the ArgR (arginine-responsive regulatory protein) regulon in our previous study, they did not include any genes of the arginine dehydrogenase (ADH) pathway.
  • In this study, 18 putative transcriptional units of 38 genes, including the two known genes of the ADH pathway, kauB and gbuA, were found to be inducible by exogenous L-arginine in the absence of ArgR.
  • To identify the missing genes that encode enzymes for the initial steps of the ADH pathway, the potential physiological functions of those candidate genes in arginine utilization were studied by growth phenotype analysis of knockout mutants.

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  • (PMID = 17416670.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Recombinant Fusion Proteins; 94ZLA3W45F / Arginine; EC 2.3.- / Acyltransferases; EC 2.3.1.- / arginine succinyltransferase; EC 2.6.1.- / Transaminases; EC 4.1.1.- / Carboxy-Lyases
  • [Other-IDs] NLM/ PMC1913404
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72. Jelski W, Chrostek L, Laszewicz W, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzyme activity in the sera of patients with Helicobacter pylori infection. Dig Dis Sci; 2007 Jun;52(6):1513-6
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  • [Title] Alcohol dehydrogenase (ADH) isoenzyme activity in the sera of patients with Helicobacter pylori infection.
  • Human gastric mucosa contains three classes of alcohol dehydrogenase (ADH) isoenzymes: I, III, and IV.
  • Various factors have been found to influence gastric ADH activity.
  • One of them is Helicobacter pylori infection, which is associated with gastric mucosal injury and leads to a decrease in gastric ADH activity.
  • The aim of the study was to assess the effect of H. pylori infection on the serum activity of ADH isoenzymes.
  • The activities of class III and IV ADH isoenzymes were measured by the photometric method with formaldehyde and with m-nitrobenzaldehyde as substrate, respectively.
  • Total activity of ADH was measured by a photometric method with p-nitrosodimethylaniline.
  • The total activities of ADH and class IV isoenzyme were significantly higher in sera of patients with H. pylori infection compared to healthy subjects.
  • The serum activity of other tested isoenzymes of ADH did not differ significantly between infected and noninfected groups.
  • We conclude that H. pylori infection of gastric mucosa is reflected in the serum by a significant increase in class IV and total ADH activity.

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  • (PMID = 17404875.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 1.1.1.1 / Alcohol Dehydrogenase
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73. Hoogerbrugge N, Bult P, Bonenkamp JJ, Ligtenberg MJ, Kiemeney LA, de Hullu JA, Boetes C, Niermeijer MF, Brunner HG: Numerous high-risk epithelial lesions in familial breast cancer. Eur J Cancer; 2006 Oct;42(15):2492-8
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  • [Title] Numerous high-risk epithelial lesions in familial breast cancer.
  • PURPOSE: To assess the occurrence of high-risk epithelial lesions in women of breast cancer families with and without a BRCA mutation.
  • PATIENTS AND METHODS: Prospective study of women at very high risk of breast cancer undergoing prophylactic mastectomy (68 BRCA1 mutation carriers, 14 BRCA2 mutation carriers and 24 non-BRCA mutation carriers).
  • RESULTS: The prevalence of high-risk lesions is equal in women with a BRCA1 or a BRCA2 mutation, but is higher in non-BRCA mutation carriers: all lesions 43% versus 71% (p=0.02), atypical lobular hyperplasia 26% versus 67% (p=0.001), atypical ductal hyperplasia 17% versus 42% (p=0.01), lobular carcinoma-in situ 15% versus 29% (p=0.10) and ductal carcinoma-in situ 9% versus 17% (p=0.25).
  • CONCLUSION: Women with an autosomal dominant family history for breast cancer, with and without a BRCA mutation are prone to develop high-risk epithelial lesions, especially over 40 years.
  • [MeSH-major] Breast Neoplasms / genetics. Genes, BRCA1. Genes, BRCA2


74. Peña-Fronteras JT, Villalobos MC, Baltazar AM, Merca FE, Ismail AM, Johnson DE: Adaptation to flooding in upland and lowland ecotypes of Cyperus rotundus, a troublesome sedge weed of rice: tuber morphology and carbohydrate metabolism. Ann Bot; 2009 Jan;103(2):295-302
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  • METHODS: Upland and lowland ecotypes of C. rotundus were compared in terms of growth habit, carbohydrate reserves and metabolism, and activities of enzymes involved in alcoholic fermentation - alcohol dehydrogenase (ADH) and pyruvate decarboxylase (PDC).
  • At 24 h after germination in hypoxic conditions, PDC and ADH activities in the lowland plants increased, before decreasing at 48 h following germination.
  • In contrast, ADH and PDC activities in the upland plants increased from 24 to 48 h after germination.
  • This is coupled with the modulation of ADH and PDC activities during germination, possibly to control the use of carbohydrate reserves and sustain substrate supply in order to avoid starvation and death of seedlings with prolonged flooding.

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  • (PMID = 18515404.001).
  • [ISSN] 1095-8290
  • [Journal-full-title] Annals of botany
  • [ISO-abbreviation] Ann. Bot.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9005-25-8 / Starch; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 3.2.1.- / Amylases; EC 4.1.1.1 / Pyruvate Decarboxylase
  • [Other-IDs] NLM/ PMC2707299
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75. Hanai T, Atsumi S, Liao JC: Engineered synthetic pathway for isopropanol production in Escherichia coli. Appl Environ Microbiol; 2007 Dec;73(24):7814-8
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  • The strain with the combination of C. acetobutylicum thl (acetyl-coenzyme A [CoA] acetyltransferase), E. coli atoAD (acetoacetyl-CoA transferase), C. acetobutylicum adc (acetoacetate decarboxylase), and C. beijerinckii adh (secondary alcohol dehydrogenase) achieved the highest titer.

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  • (PMID = 17933911.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.1.80 / isopropanol dehydrogenase (NADP); EC 2.3.1.9 / Acetyl-CoA C-Acetyltransferase; EC 4.1.1.- / Carboxy-Lyases; EC 4.1.1.4 / acetoacetate decarboxylase; ND2M416302 / 2-Propanol
  • [Other-IDs] NLM/ PMC2168132
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76. Campbell CT: Transition metal oxides: extra thermodynamic stability as thin films. Phys Rev Lett; 2006 Feb 17;96(6):066106
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  • The adhesion energy at this interface (E(adh,ox/m)) provides extra stabilization, which lowers the O2 pressure required for oxide stability as a thin film below that required for bulk-oxide stability by the factor exp[(2gamma(g/ox) - E(adh,ox/m))/(tN(ox)RT)], where gamma(g/ox) is the surface energy of the oxide, t is the oxide film thickness, and N(ox) is the oxygen concentration in the bulk oxide (moles O2 per volume).

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  • (PMID = 16606017.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Lührs AK, Guhr S, Schilke R, Borchers L, Geurtsen W, Günay H: Shear bond strength of self-etch adhesives to enamel with additional phosphoric acid etching. Oper Dent; 2008 Mar-Apr;33(2):155-62
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  • In half of each test group, ground enamel surfaces were coated with the self-etch adhesives AdheSe (ADH), Xeno III (XE) or Futurabond NR (FNR).

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  • (PMID = 18435189.001).
  • [ISSN] 0361-7734
  • [Journal-full-title] Operative dentistry
  • [ISO-abbreviation] Oper Dent
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / AdheSE cement; 0 / CeramX; 0 / Composite Resins; 0 / Dentin-Bonding Agents; 0 / Methacrylates; 0 / Phosphoric Acids; 0 / Resin Cements; 0 / Syntac dentine adhesive; 0 / Tetric EvoCeram; 0 / Xeno III; 0 / futurabond NR; 059QF0KO0R / Water; E4GA8884NN / phosphoric acid
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78. Ding HY, Yang GZ: [Clinicopathological features of the mucocele-like lesions in the breast]. Zhonghua Bing Li Xue Za Zhi; 2008 Jan;37(1):31-4
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  • [Title] [Clinicopathological features of the mucocele-like lesions in the breast].
  • OBJECTIVE: To study the clinical and pathological features of mucocele-like lesions in the breast.
  • METHODS: Nine cases of mucocele-like lesions in the breast were reported for the morphological and immunohistochemical features, the differential diagnosis, and a literature review.
  • RESULTS: All nine cases were from female patients, aged 23 to 43 years (mean 34 years), clinically presented with palpable breast masses.
  • There were superimposed papillary epithelial hyperplasia in three cases and atypical ductal hyperplasia in one.
  • CONCLUSION: Mucocele-like lesions of the breast is a group of mostly benign disease, and the differential diagnosis should include mucinous carcinoma.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Hyperplasia / pathology. Mucocele / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Carcinoma in Situ / diagnosis. Female. Gene Expression Regulation, Neoplastic / physiology. Humans. Intestinal Neoplasms / pathology

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  • (PMID = 18509982.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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79. Rao R, Zhang MZ, Zhao M, Cai H, Harris RC, Breyer MD, Hao CM: Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol; 2005 Apr;288(4):F642-9
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  • Lithium also induced renal medullary COX2 protein expression in congenitally polyuric antidiuretic hormone (AHD)-deficient rats, demonstrating that lithium-induced COX2 protein expression is not secondary to altered ADH levels or polyuria.

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  • (PMID = 15585669.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / 2P50-DK-39261; United States / NIDDK NIH HHS / DK / DK-065024
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 1.14.99.1 / Ptgs1 protein, mouse; EC 1.14.99.1 / Ptgs1 protein, rat; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3; G4962QA067 / Lithium Chloride; K7Q1JQR04M / Dinoprostone
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80. Crichton PG, Affourtit C, Moore AL: Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism. Biochem J; 2007 Jan 15;401(2):459-64
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  • In the present study we have shown that mitochondria isolated from Schizosaccharomyces pombe exhibit antimycin A-sensitive oxygen uptake activity that is exclusively dependent on ethanol and is inhibited by trifluoroethanol, a potent inhibitor of ADH (alcohol dehydrogenase).
  • Ethanol-dependent respiratory activity has, to our knowledge, not been reported in S. pombe mitochondria to date, which is surprising as it has been concluded previously that only one ADH gene, encoding a cytosolic enzyme, occurs in this yeast.
  • Spectrophotometric enzyme assays reveal that ADH activity in isolated mitochondria is increased approximately 16-fold by Triton X-100, which demonstrates that the enzyme is located in the matrix.
  • Using genetic knockouts, we show conclusively that the novel mitochondrial ADH is encoded by adh4 and, as such, is unrelated to ADH isoenzymes found in mitochondria of other yeasts.

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  • (PMID = 16999687.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isoenzymes; EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ PMC1820810
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81. Powers RH, Dean DE: Evaluation of potential lactate/lactate dehydrogenase interference with an enzymatic alcohol analysis. J Anal Toxicol; 2009 Oct;33(8):561-3
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  • The Connecticut Department of Public Safety laboratory recently addressed a legal challenge to a hospital alcohol dehydrogenase (ADH)-based serum ethanol determination based on the suggestion of interference by lactate dehydrogenase (LDH)-catalyzed oxidation of lactate.
  • Both ADH- and LDH-oxidations require NAD(+) (present in excess in the assay).
  • Calculation of the amount of LDH and ADH present in the ethanol assay suggest an ADH/LDH ratio of 200:1.

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  • (PMID = 19874670.001).
  • [ISSN] 1945-2403
  • [Journal-full-title] Journal of analytical toxicology
  • [ISO-abbreviation] J Anal Toxicol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Reagent Kits, Diagnostic; 33X04XA5AT / Lactic Acid; 3K9958V90M / Ethanol; EC 1.1.- / Lactate Dehydrogenases; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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82. Montjoy CA, Rahman A, Teba L: Ethylene glycol and methanol poisonings: case series and review. W V Med J; 2010 Sep-Oct;106(6):17-23
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  • MATERIALS AND METHODS: A retrospective chart review of all adult patients admitted to our institution with a diagnosis of EG or MTH intoxication during a 15-year period was done.
  • Age, sex, EG and MTH levels, degree of acidosis, initial anion and osmolar gaps, renal dysfunction, length of stay in the hospital, need for dialysis, and ADH (alcohol dehydrogenase) blockade treatment were recorded.
  • One must rely on laboratory data for clues in making a diagnosis of intoxication.
  • [MeSH-minor] Acidosis / diagnosis. Adult. Female. Humans. Male. Middle Aged. Poisoning / diagnosis. Poisoning / physiopathology. Retrospective Studies

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  • (PMID = 21928557.001).
  • [ISSN] 0043-3284
  • [Journal-full-title] The West Virginia medical journal
  • [ISO-abbreviation] W V Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Solvents; FC72KVT52F / Ethylene Glycol; Y4S76JWI15 / Methanol
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83. Larriba MJ, Valle N, Pálmer HG, Ordóñez-Morán P, Alvarez-Díaz S, Becker KF, Gamallo C, de Herreros AG, González-Sancho JM, Muñoz A: The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. Endocr Relat Cancer; 2007 Mar;14(1):141-51
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  • The transcription factor Snail1 represses VDR expression and we demonstrate here that Snail1 also abolishes the nuclear export of beta-catenin induced by 1,25(OH)(2)D(3) in SW480-ADH cells.

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  • (PMID = 17395983.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Microfilament Proteins; 0 / Neuropeptides; 0 / Nuclear Proteins; 0 / Receptors, Calcitriol; 0 / Transcription Factors; 0 / Wnt Proteins; 0 / beta Catenin; 0 / dihydroxy-vitamin D3; 0 / ectodermal-neural cortex 1 protein; 0 / snail family transcription factors; 1406-16-2 / Vitamin D; FXC9231JVH / Calcitriol; Q0OZ0D9223 / seocalcitol
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84. Toyama H, Chen ZW, Fukumoto M, Adachi O, Matsushita K, Mathews FS: Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5. J Mol Biol; 2005 Sep 9;352(1):91-104
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  • [Title] Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5.
  • Depending on the alcohols used as growth substrates, Pseudomonas putida HK5 produces two distinct quinohemoprotein alcohol dehydrogenases, ADH-IIB and ADH-IIG, both of which contain pyrroloquinoline quinone (PQQ) and heme c as the prosthetic groups but show different substrate specificities, especially for diol substrates.
  • Molecular cloning of the gene of ADH-IIB and its crystal structure are already reported.
  • Here, molecular cloning of the gene, qgdA, and solution of the three-dimensional structure of ADH-IIG are reported.
  • The crystal structure of ADH-IIG, determined at 2.2A resolution, shows that the overall structure and the amino acid residues involved in PQQ binding are quite similar to ADH-IIB and to another quinohemoprotein ADH, qhEDH from Comamonas testosteroni.
  • Apart from ADH-IIB and qhEDH, ADH-IIG has an extra 12-residue helix within loop 3 in the PQQ domain and an extra 3(10) helix in the C terminus of the cytochrome domain, and both helices appear parallel and linked by a hydrogen bond.
  • In the crystal structure of ADH-IIG with 1,2-propanediol, one of the hydroxyl groups of the substrate forms a hydrogen bond with O5 of PQQ and OD1 of Asp300, and the other interacts with a water molecule and with NE2 of Trp386, the corresponding residue of which is not found in ADH-IIB and qhEDH, and might be the residue responsible for making ADH-IIG prefer diol substrates.

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  • (PMID = 16061256.001).
  • [ISSN] 0022-2836
  • [Journal-full-title] Journal of molecular biology
  • [ISO-abbreviation] J. Mol. Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB204833
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Isoenzymes; 9007-43-6 / Cytochromes c; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.2.8 / alcohol dehydrogenase (acceptor)
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85. Edenberg HJ, Xuei X, Chen HJ, Tian H, Wetherill LF, Dick DM, Almasy L, Bierut L, Bucholz KK, Goate A, Hesselbrock V, Kuperman S, Nurnberger J, Porjesz B, Rice J, Schuckit M, Tischfield J, Begleiter H, Foroud T: Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet; 2006 May 1;15(9):1539-49
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  • Linkage evidence indicated that gene(s) located on chromosome 4q, in the region of the alcohol dehydrogenase (ADH) genes, affected risk for alcoholism.
  • We genotyped 110 single nucleotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism in a set of families with multiple alcoholic members, using the pedigree disequilibrium test.

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  • (PMID = 16571603.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / U10AA008401
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
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86. Mossé IB, Mikhaĭlova ME, Glushkova IV, Kasinskaia SI, Anoshenko IP, Aksiutik TV, Tikhanovich NI, Kamysh NA: [Genetic monitoring of natural Drosophila populations in radiation contaminated regions of Belarus]. Radiats Biol Radioecol; 2006 May-Jun;46(3):287-95
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  • The dominant and recessive lethal mutation levels and genetic structure of the populations were analyzed for frequencies of F- and S-alleles of Adh (alcohol dehydrogenase) of Gpdh (glycerinophosphate dehydrogenase) and Sod (superoxide dismutase) loci.

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  • (PMID = 16869160.001).
  • [ISSN] 0869-8031
  • [Journal-full-title] Radiatsionnaia biologiia, radioecologiia
  • [ISO-abbreviation] Radiats Biol Radioecol
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Drosophila Proteins; 0 / Radioactive Pollutants; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.- / Glycerolphosphate Dehydrogenase; EC 1.1.1.1 / ADH protein, Drosophila; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.15.1.1 / Superoxide Dismutase
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87. Lutz P, Maring D, Tschampa HJ, Sauerbruch T: [A 25-year-old patient with colonic pseudo-obstruction, hyponatremia, hypertension, and diffuse pain]. Med Klin (Munich); 2010 Apr;105(4):267-72
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  • Shortly after admission, she developed generalized seizures while hyponatremia increased compatible with SIADH (syndrome of inadequate ADH secretion).
  • Since porphobilinogen deaminase activity was clearly decreased, diagnosis of acute intermittent porphyria could be confirmed.
  • CONCLUSION: This case shows how definite diagnosis of this illness is often delayed because of its rarity and the variety of its possible symptoms and signs.
  • [MeSH-major] Colonic Pseudo-Obstruction / etiology. Hypertension / etiology. Hyponatremia / etiology. Pain / etiology. Porphyria, Acute Intermittent / diagnosis
  • [MeSH-minor] Adult. Delayed Diagnosis. Diagnosis, Differential. Epilepsy, Generalized / etiology. Female. Humans. Hydroxymethylbilane Synthase. Inappropriate ADH Syndrome / diagnosis

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  • (PMID = 20455047.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.5.1.61 / Hydroxymethylbilane Synthase
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88. Guo Y, Wu XQ, Zhang C, Liao ZX, Wu Y, Xia ZY, Wang H: Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices. Clin Exp Pharmacol Physiol; 2010 Dec;37(12):1107-13
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  • In I3C groups, cytochrome P450 (CYP) 2E1 activities were inhibited by 40.9-51.8%, whereas alcohol dehydrogenase (ADH) activity was enhanced 1.6-fold compared with the ethanol-treated group.

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  • [Copyright] © 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd.
  • [CommentIn] Clin Exp Pharmacol Physiol. 2012 Jul;39(7):642 [22738366.001]
  • (PMID = 20880187.001).
  • [ISSN] 1440-1681
  • [Journal-full-title] Clinical and experimental pharmacology & physiology
  • [ISO-abbreviation] Clin. Exp. Pharmacol. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Actins; 0 / Indoles; 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / Transforming Growth Factor beta1; 0 / smooth muscle actin, rat; 3K9958V90M / Ethanol; 9007-34-5 / Collagen; C11E72455F / indole-3-carbinol; EC 3.4.24.7 / Matrix Metalloproteinase 1; GO1N1ZPR3B / Acetaldehyde
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89. Lysak MA, Koch MA, Beaulieu JM, Meister A, Leitch IJ: The dynamic ups and downs of genome size evolution in Brassicaceae. Mol Biol Evol; 2009 Jan;26(1):85-98
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  • Evolution of GS was analyzed within a phylogenetic framework based on gene trees built from five data sets (matK, chs, adh, trnLF, and ITS).

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  • (PMID = 18842687.001).
  • [ISSN] 1537-1719
  • [Journal-full-title] Molecular biology and evolution
  • [ISO-abbreviation] Mol. Biol. Evol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Robinson D: Nocturia in women. Int J Clin Pract Suppl; 2007 Sep;(155):23-31
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  • When evaluating women complaining of nocturia a urinary diary and clinical examination is integral to making the diagnosis prior to commencing treatment.
  • Should this conservative approach fail then treatment with antimuscarinic agents or desmopressin, a nona-peptide analogue of anti-diuretic hormone (ADH) is often helpful.

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  • (PMID = 17727576.001).
  • [ISSN] 1368-504X
  • [Journal-full-title] International journal of clinical practice. Supplement
  • [ISO-abbreviation] Int J Clin Pract Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 58
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91. Thompson CE, Fernandes CL, de Souza ON, de Freitas LB, Salzano FM: Evaluation of the impact of functional diversification on Poaceae, Brassicaceae, Fabaceae, and Pinaceae alcohol dehydrogenase enzymes. J Mol Model; 2010 May;16(5):919-28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Several studies point to functional diversification of the ADH, with evidence of its importance, in different organisms, in the ethanol, norepinephrine, dopamine, serotonin, and bile acid metabolism.
  • The main objective of this article is to establish a correlation between the functional diversification occurring in the plant alcohol dehydrogenase family and the three-dimensional structures predicted for 17 ADH belonging to Poaceae, Brassicaceae, Fabaceae, and Pinaceae botanical families.

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  • (PMID = 19834749.001).
  • [ISSN] 0948-5023
  • [Journal-full-title] Journal of molecular modeling
  • [ISO-abbreviation] J Mol Model
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
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92. Scaperrotta G, Ferranti C, Costa C, Mariani L, Marchesini M, Suman L, Folini C, Bergonzi S: Role of sonoelastography in non-palpable breast lesions. Eur Radiol; 2008 Nov;18(11):2381-9
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  • [Title] Role of sonoelastography in non-palpable breast lesions.
  • The purpose of this study was to evaluate the diagnostic utility of sonoelastography in differentiating benign from malignant non-palpable breast lesions.
  • A total of 293 BI-RADS 3-5 (Breast Imaging Reporting And Data System) impalpable breast lesions in 278 women was evaluated with B-mode ultrasound (US) and subsequently with sonoelastography (SE) before performing US-guided biopsy.
  • Lesions that were malignant or showed atypical ductal hyperplasia were referred for surgical excision, as well as 32 benign lesions showing discordance between US/SE results and histology.
  • SE is a simple, fast and non-invasive diagnostic method that may be a useful aid to US for less experienced radiologists in the assessment of solid non-palpable breast lesions, especially BI-RADS 3, where specificity was higher (88.7%).
  • [MeSH-major] Breast Neoplasms / diagnostic imaging. Elasticity Imaging Techniques / methods. Ultrasonography, Mammary / methods

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  • (PMID = 18523780.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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93. Emerson RO, Sage EH, Ghosh JG, Clark JI: Chaperone-like activity revealed in the matricellular protein SPARC. J Cell Biochem; 2006 Jul 1;98(4):701-5
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  • Unfolding and aggregation of the chaperone target protein, alcohol dehydrogenase (ADH), were initiated at 50 degrees C.
  • SPARC inhibited the thermal aggregation of ADH in a concentration-dependent manner, with maximal inhibition at a 1:4 molar ratio of SPARC:ADH.

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16598771.001).
  • [ISSN] 0730-2312
  • [Journal-full-title] Journal of cellular biochemistry
  • [ISO-abbreviation] J. Cell. Biochem.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY004542; United States / NEI NIH HHS / EY / EY13180; United States / NIGMS NIH HHS / GM / GM40711
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Molecular Chaperones; 0 / Osteonectin; 0 / alpha-Crystallins; 0 / beta-Crystallins; EC 1.1.1.1 / Alcohol Dehydrogenase
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94. Calaf GM, Echiburú-Chau C, Zhao YL, Hei TK: BigH3 protein expression as a marker for breast cancer. Int J Mol Med; 2008 May;21(5):561-8
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  • [Title] BigH3 protein expression as a marker for breast cancer.
  • For breast cancer development, this multistep process may manifest itself as a sequence of pathologically defined stages.
  • It is widely held that breast cancer originates at the premalignant stage of atypical ductal hyperplasia, progresses to the preinvasive stage of ductal carcinoma in situ, and culminates in the potentially lethal stage of invasive ductal carcinoma.
  • Tumor grade has been a highly valuable prognostic factor for breast cancer, and high-grade ductal carcinoma in situ lesions are associated with poor clinical outcome.
  • The aim of this work was to investigate the BigH3 protein expression changes associated with various stages of breast cancer progression in comparison to benign specimens using tissue microarray technology.
  • Pathological characteristics of breast tissues ranged from benign lesions to breast cancers either of lobular or ductal carcinomas in origin, and included in situ ductal carcinomas, lobular carcinomas, infiltrating ductal carcinomas, carcinomas, scirrhous carcinomas, adenocarcinomas and infiltrating colloid carcinomas.
  • BigH3 protein expression was analyzed by immunohistochemistry in 192 cases of breast tumors.
  • Results indicated a decrease in BigH3 protein expression from benign tissues to in situ ductal carcinoma, lobular carcinoma, infiltrating ductal carcinomas, carcinomas, scirrhous carcinoma, adenocarcinomas to infiltrating colloid carcinomas.
  • In summary, these studies confirmed the suppressor effect of the BigH3 gene expressed as protein expression in those processes related to the progression of breast tumorigenesis.
  • We conclude that this protein can be used as a marker for breast cancer progression.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Breast Neoplasms / metabolism. Extracellular Matrix Proteins / metabolism. Transforming Growth Factor beta / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Mammary Glands, Human / cytology. Mammary Glands, Human / metabolism. Mammary Glands, Human / pathology. Microarray Analysis. Middle Aged

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  • (PMID = 18425347.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Grant] United States / PHS HHS / / NAG2 1637; United States / NIEHS NIH HHS / ES / P30 ES 09089
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Extracellular Matrix Proteins; 0 / Transforming Growth Factor beta; 148710-76-3 / betaIG-H3 protein
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95. Birley AJ, Whitfield JB, Neale MC, Duffy DL, Heath AC, Boomsma DI, Martin NG: Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. Behav Genet; 2005 Sep;35(5):509-24
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  • Nearly all participants were subsequently genotyped on two polymorphic SNPs in the ADH1B and ADH1C loci known to affect in vitro ADH activity.
  • In the DZ pairs, 14 microsatellite markers covering a 20.5 cM region on chromosome 4 that includes the ADH gene family were assessed, Variation in the timed series of autocorrelated blood and breath alcohol readings was studied using a bivariate simplex design.
  • The contribution of a quantitative trait locus (QTL) or QTL's linked to the ADH region was estimated via a mixture of likelihoods weighted by identity-by-descent probabilities.
  • This implies that there is a major determinant of variation for in vivo alcohol metabolism in the ADH region that is not accounted for by these polymorphisms.

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  • (PMID = 16184481.001).
  • [ISSN] 0001-8244
  • [Journal-full-title] Behavior genetics
  • [ISO-abbreviation] Behav. Genet.
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / AA013321; United States / NIAAA NIH HHS / AA / AA013326; United States / NIAAA NIH HHS / AA / AA014041; United States / NIAAA NIH HHS / AA / AA077281; United States / NIMH NIH HHS / MH / MH-65322
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase
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96. Fukuhara K, Omura T, Katsuragi K, Osugi H, Lee S, Kishida S: [A case of severe electrolytic disorder after adjuvant chemotherapy for esophageal cancer]. Gan To Kagaku Ryoho; 2009 Aug;36(8):1359-61
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  • [Title] [A case of severe electrolytic disorder after adjuvant chemotherapy for esophageal cancer].
  • An electrolytic disorder was found on day 2, and her consciousness became unclear on 5 day (respective Na, K and Cl values of 113, 2.2 and 67 mEq/L in blood).
  • As the b2-microglobulin level was high in urine and the ADH level in blood was normal, cisplatinum nephrotoxicity was thought to make this accident.
  • Electrolytes should be checked carefully for disorder during chemotherapy.


97. Tang F, Gu DH, Wang H, Zhu TF, Zhu HG, Xu ZD, Hu XQ: [Expression and significance of hTERT mRNA in breast carcinoma and its relation to p53]. Zhonghua Zhong Liu Za Zhi; 2006 Mar;28(3):192-5
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  • [Title] [Expression and significance of hTERT mRNA in breast carcinoma and its relation to p53].
  • OBJECTIVE: This study was designed to investigate the significance of hTERT mRNA in breast carcinogenesis and to explore the diagnostic efficacy, and to study the effect of tumor suppressor gene p53 on the expression of hTERT mRNA.
  • METHODS: The expression of hTERT mRNA was examined by in situ hybridization in 12 cases of normal breast tissue nearby cancer, 7 of simple ductal hyperplasia, 20 of atypical hyperplasia, 18 of ductal carcinoma in situ and 25 with invasive ductal carcinoma.
  • RESULTS: hTERT was not detected in normal breast tissue nearby cancer and simple ductal hyperplasia.
  • The positive rate of hTERT mRNA in atypical hyperplasia, ductal carcinoma in situ and invasive ductal carcinoma were 25.0%, 83.3% and 88.0%, respectively.
  • The prevalence and intensity of hTERT mRNA expression were much greater in carcinoma than those in simple or atypical hyperplasia and normal breast tissue nearby cancer (P < 0.05).
  • The positive correlation between hTERT mRNA and p53 was found in breast carcinoma (r = 0.5540, P < 0.01).
  • CONCLUSION: hTERT mRNA expression is closely related to the malignant transformation of breast tissue.
  • Semi-quantitative detection of hTERT mRNA expression in situ is helpful in differentiated diagnosis of carcinoma in situ and atypical hyperplasia.
  • Inactivation of p53 may play a role in the transcriptive activation of hTERT gene in breast carcinoma.
  • [MeSH-major] Breast Neoplasms / metabolism. Carcinoma, Ductal, Breast / metabolism. Telomerase / biosynthesis
  • [MeSH-minor] Adult. Breast / metabolism. Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / pathology. Diagnosis, Differential. Disease Progression. Humans. Hyperplasia. Lymphatic Metastasis. Middle Aged. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Tumor Suppressor Protein p53

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  • (PMID = 16875603.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tumor Suppressor Protein p53; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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98. Zhang L, Xu Z, Sun X, Dong S: A novel alcohol dehydrogenase biosensor based on solid-state electrogenerated chemiluminescence by assembling dehydrogenase to Ru(bpy)(3)2+-Au nanoparticles aggregates. Biosens Bioelectron; 2007 Jan 15;22(6):1097-100
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  • Based on electrogenerated chemiluminescence (ECL), a novel method for fabrication of alcohol dehydrogenase (ADH) biosensor by self-assembling ADH to Ru(bpy)(3)(2+)-AuNPs aggregates (Ru-AuNPs) on indium tin oxide (ITO) electrode surface has been developed.

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  • (PMID = 16815003.001).
  • [ISSN] 0956-5663
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzymes, Immobilized; 3K9958V90M / Ethanol; 7440-57-5 / Gold; EC 1.1.1.1 / Alcohol Dehydrogenase; MLT4718TJW / Rubidium
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99. Albarracin CT, Nguyen CV, Whitman GJ, Yang W, Sneige N: Identifying patients with atypical ductal hyperplasia diagnosed at core-needle biopsy who are at low risk of malignancy. Radiology; 2010 Dec;257(3):893-4; author reply 984
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  • [Title] Identifying patients with atypical ductal hyperplasia diagnosed at core-needle biopsy who are at low risk of malignancy.
  • [MeSH-major] Biopsy, Fine-Needle / instrumentation. Breast / pathology. Breast Neoplasms / pathology. Calcinosis / pathology. Carcinoma, Ductal, Breast / pathology

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  • [CommentOn] Radiology. 2010 Jun;255(3):723-30 [20173103.001]
  • [ErratumIn] Radiology. 2011 Mar;258(3):962. Weiang, Wei [corrected to Yang, Wei]
  • (PMID = 21084420.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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100. Weinreb I, Tabanda-Lichauco R, Van der Kwast T, Perez-Ordoñez B: Low-grade intraductal carcinoma of salivary gland: report of 3 cases with marked apocrine differentiation. Am J Surg Pathol; 2006 Aug;30(8):1014-21