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6. Jallades L, Hayette S, Tigaud I, Johnston A, Coiffier B, Magaud JP, Ffrench M: Emergence of therapy-unrelated CML on a background of BCR-ABL-negative JAK2V617F-positive chronic idiopathic myelofibrosis. Leuk Res; 2008 Oct;32(10):1608-10
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  • [Title] Emergence of therapy-unrelated CML on a background of BCR-ABL-negative JAK2V617F-positive chronic idiopathic myelofibrosis.
  • We report the emergence of a chronic myeloid leukaemia (CML) during the course of a JAK2V617F-positive chronic idiopathic myelofibrosis (CIMF) in the absence of any myelosuppressive treatment.
  • Such rare patients with co-existing BCR-ABL translocation and JAK2V617F mutation must be identified in view of the possibility of targeted therapies.
  • Moreover, the detection of BCR-ABL translocation appears to be crucial especially in the case of treated CIMF with an atypical course to identify CML before acute transformation.
  • [MeSH-major] Janus Kinase 2 / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Primary Myelofibrosis / complications
  • [MeSH-minor] Amino Acid Substitution. Chronic Disease. Fusion Proteins, bcr-abl / genetics. Humans. Male. Middle Aged. Point Mutation. RNA, Messenger / analysis

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  • [CommentIn] Leuk Res. 2008 Oct;32(10):1489-90 [18439674.001]
  • (PMID = 18448166.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.10.2 / Fusion Proteins, bcr-abl; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2
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7. Zámecníkova A, Al Bahar S, Ramesh P: Trisomy 6 in a CML patient receiving imatinib mesylate therapy. Leuk Res; 2008 Sep;32(9):1454-7
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  • [Title] Trisomy 6 in a CML patient receiving imatinib mesylate therapy.
  • The emergence of chromosome abnormalities in Philadelphia-negative cells in chronic myelogenous leukemia patients during imatinib therapy have been described by several authors.
  • We describe a patient with Philadelphia chromosome-positive chronic myelogenous leukemia diagnosed in 1998, in whom multiple clonal abnormalities were identified in Ph-negative cells while on imatinib therapy.
  • The patient developed lymphoid blast crisis associated with an additional Ph chromosome and trisomy 6 in Ph-negative cells.
  • [MeSH-major] Chromosomes, Human, Pair 6 / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Piperazines / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Pyrimidines / therapeutic use. Trisomy

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  • (PMID = 18294688.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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8. Satran A, Dawn B, Leesar MA: Congenital ostial left main coronary artery stenosis associated with a bicuspid aortic valve in a young woman. J Invasive Cardiol; 2006 Mar;18(3):E114-6
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  • [Title] Congenital ostial left main coronary artery stenosis associated with a bicuspid aortic valve in a young woman.
  • Coronary angiography demonstrated an ambiguous left main coronary artery (LMCA) stenosis.
  • Intravascular ultrasound (IVUS) demonstrated no atheroma, but the minimum lumen diameter and area of the ostial LMCA were significantly reduced.
  • Transesophageal echocardiography showed normal left ventricular function with a bicuspid aortic valve.
  • Two-vessel coronary artery bypass grafting was subsequently performed.
  • To our knowledge, this is the first IVUS-documented case of a congenital left main coronary artery stenosis associated with a bicuspid aortic valve.
  • [MeSH-minor] Adult. Coronary Artery Bypass. Coronary Vessels / ultrasonography. Echocardiography, Transesophageal. Female. Humans. Ultrasonography, Interventional

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  • (PMID = 16495606.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Yoong Y, VanDeWalker TJ, Carlson RO, Dewald GW, Tefferi A: Clinical correlates of submicroscopic deletions involving the ABL-BCR translocation region in chronic myeloid leukemia. Eur J Haematol; 2005 Feb;74(2):124-7
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  • [Title] Clinical correlates of submicroscopic deletions involving the ABL-BCR translocation region in chronic myeloid leukemia.
  • Recent reports indicate a prognostically detrimental effect of submicroscopic abl-bcr deletions associated with the break and fusion points of the derivative chromosome 9 [der(9)] in chronic myeloid leukemia (CML).
  • In a retrospective cohort of 92 patients with CML, the incidence of an atypical D-FISH pattern, that is consistent with a der(9) deletion was 20%.
  • At a median follow-up of 31 months, the incidence of disease transformation, drug therapy response, and survival were similar between the two groups.
  • These results are contrary to previous reports that suggested inferior survival as well as poor response to alpha interferon therapy in CML patients carrying der(9) deletions.
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. Fusion Proteins, bcr-abl / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Sequence Deletion / genetics
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Disease-Free Survival. Female. Humans. In Situ Hybridization, Fluorescence. Interferon-alpha / administration & dosage. Karyotyping. Leukocyte Count. Male. Organ Size. Platelet Count. Prognosis. Spleen / pathology


10. Park SJ, Kim YH, Lee BK, Lee SW, Lee CW, Hong MK, Kim JJ, Mintz GS, Park SW: Sirolimus-eluting stent implantation for unprotected left main coronary artery stenosis: comparison with bare metal stent implantation. J Am Coll Cardiol; 2005 Feb 1;45(3):351-6
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  • [Title] Sirolimus-eluting stent implantation for unprotected left main coronary artery stenosis: comparison with bare metal stent implantation.
  • OBJECTIVES: This study was designed to compare the clinical and angiographic outcomes of sirolimus-eluting stent (SES) and bare metal stent (BMS) implantation for unprotected left main coronary artery (LMCA) stenosis.
  • BACKGROUND: The safety and effectiveness of SES implantation for unprotected LMCA stenosis have not been ascertained.
  • METHODS: Elective SES implantation for de novo unprotected LMCA stenosis was performed in 102 consecutive patients with preserved left ventricular function from March 2003 to March 2004.
  • CONCLUSIONS: Sirolimus-eluting stent implantation for unprotected LMCA stenosis appears safe with regard to acute and midterm complications and is more effective in preventing restenosis compared to BMS implantation.

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  • (PMID = 15680711.001).
  • [ISSN] 0735-1097
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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11. Deininger MW, Cortes J, Paquette R, Park B, Hochhaus A, Baccarani M, Stone R, Fischer T, Kantarjian H, Niederwieser D, Gambacorti-Passerini C, So C, Gathmann I, Goldman JM, Smith D, Druker BJ, Guilhot F: The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells. Cancer; 2007 Oct 1;110(7):1509-19
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  • [Title] The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells.
  • BACKGROUND: Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)-negative cells in some patients with chronic myeloid leukemia (CML) who attained a cytogenetic response to imatinib mesylate.
  • In some patients, CCA/Ph-negative status was associated with myelodysplasia or acute myeloid leukemia.
  • The objective of the current study was to determine the prognostic impact of CCA/Ph-negative cells.
  • METHODS: The authors compared the pretherapeutic risk factors (Kruskall-Wallis test), exposure to cytotoxic drugs (chi-square test), and overall and progression-free survival (Kaplan-Meyer and logistic regression analysis, respectively) of 515 patients with mostly chronic-phase CML who were treated with imatinib mesylate after failure of interferon-alpha according to whether they attained a major cytogenetic response (MCR) (n = 324 patients), an MCR with CCA/Ph-negative status (n = 30 patients), or no MCR (n = 161 patients).
  • RESULTS: CCA/Ph-negative status most frequently involved chromosomes Y, 8, and 7.
  • No significant differences in pretherapeutic risk factors were detected between patients who attained an MCR with and without CCA/Ph-negative cells, except that exposure to alkylating agents was more frequent in patients with CCA/Ph-negative cells, and overall and progression-free survival were identical.
  • CONCLUSIONS: The overall prognosis for patients who had CML with CCA/Ph-negative status was good and was driven by the CML response to imatinib mesylate.
  • Isolated CCA/Ph-negative cells in the absence of morphologic evidence of MDS do not justify a change in therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Chromosome Aberrations. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Benzamides. Chi-Square Distribution. Chronic Disease. Cytogenetic Analysis. Disease-Free Survival. Female. Follow-Up Studies. Humans. Imatinib Mesylate. Interferon-alpha / therapeutic use. Kaplan-Meier Estimate. Logistic Models. Male. Middle Aged. Myelodysplastic Syndromes / chemically induced. Neutropenia / chemically induced. Prognosis. Thrombocytopenia / chemically induced. Treatment Failure. Treatment Outcome


12. Sakai H, Oyama N, Kishimoto N, Takahashi M, Urasawa K, Tsutsui H: Revascularization of malignant coronary instent restenosis resulting from Takayasu's arteritis using sirolimus-eluting stents. Int Heart J; 2006 Sep;47(5):795-801
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  • Since severe stenosis was observed in her left main coronary artery (LMCA) the following year, a minimally invasive direct coronary artery bypass (MIDCAB) operation was performed.
  • Unfortunately, she again complained of angina about 6 months after the second surgery and coronary angiography (CAG) revealed that her left internal thoracic artery graft was totally occluded.
  • Although a 4.0 x 15 mm S670 stent was placed in her LMCA, the LMCA re-stented every 3 months and she underwent reintervention 8 times.
  • We placed 2 sirolimus-eluting stents for treating the LMCA using the culottes stenting technique.
  • CAG 6 months after the index procedure showed no stenosis at her LMCA.
  • [MeSH-minor] Adult. Coronary Angiography. Coronary Artery Bypass. Coronary Disease / surgery. Female. Humans

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  • (PMID = 17106150.001).
  • [ISSN] 1349-2365
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] W36ZG6FT64 / Sirolimus
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13. Macdonald D, Cross NC: Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy. Pathobiology; 2007;74(2):81-8
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  • [Title] Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy.
  • The term chronic myeloproliferative disorders was originally used by Damashek to describe the link amongst a group of acquired blood diseases.
  • These may be chromosomal translocations resulting in the creation of a fusion kinase gene, examples of which include ABL, FGFR, and PDGFR as seen in disorders CML, 8p11 myeloproliferative syndrome, atypical CML and chronic eosinophilic leukaemia.
  • This abnormality is seen in 30-97% of cases of MPD with the phenotype PV, ET or CIMF.
  • [MeSH-major] Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Hypereosinophilic Syndrome / diagnosis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Myeloproliferative Disorders / diagnosis. Myeloproliferative Disorders / therapy. Protein-Tyrosine Kinases / genetics
  • [MeSH-minor] Chronic Disease. Hematopoiesis / genetics. Humans. Janus Kinase 2 / genetics. Molecular Diagnostic Techniques. Mutant Chimeric Proteins / genetics. Oncogene Proteins, Fusion / genetics. Point Mutation. Polycythemia Vera / diagnosis. Polycythemia Vera / genetics. Polycythemia Vera / therapy. Primary Myelofibrosis / diagnosis. Primary Myelofibrosis / genetics. Primary Myelofibrosis / therapy. Receptor, Fibroblast Growth Factor, Type 1 / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Receptor, Platelet-Derived Growth Factor beta / genetics. Thrombocythemia, Essential / diagnosis. Thrombocythemia, Essential / genetics. Thrombocythemia, Essential / therapy. mRNA Cleavage and Polyadenylation Factors / genetics

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  • (PMID = 17587879.001).
  • [ISSN] 1015-2008
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / FIP1L1-PDGFRA fusion protein, human; 0 / Mutant Chimeric Proteins; 0 / Oncogene Proteins, Fusion; 0 / mRNA Cleavage and Polyadenylation Factors; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2
  • [Number-of-references] 29
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4. Park SJ, Park DW: Drug-eluting stents for left main coronary artery stenosis: case selection and technical issues. Am Heart Hosp J; 2008;6(1):21-9
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  • [Title] Drug-eluting stents for left main coronary artery stenosis: case selection and technical issues.
  • The use of coronary stents for the treatment of left main coronary artery (LMCA) stenosis is feasible and is associated with a high rate of procedural success and low rates of early and late complications, such as death, myocardial infarction, and stent thrombosis, in low-risk patient populations.
  • Patients at high risk for coronary artery bypass grafting (CABG), however, have reduced event-free survival after stenting.
  • Compared with bare-metal stents for LMCA disease, the subsequent rate of target lesion revascularization appears to be diminished by use of drug-eluting stents (DESs), with similar or enhanced survival and freedom from myocardial infarction.
  • Results of prospective randomized trials comparing the use of DESs with CABG may be needed to ascertain whether DESs could be a reasonable alternative for patients with LMCA disease.
  • [MeSH-minor] Coronary Artery Bypass. Humans. Korea. Outcome Assessment (Health Care)

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  • (PMID = 18256554.001).
  • [ISSN] 1541-9215
  • [Journal-full-title] The American heart hospital journal
  • [ISO-abbreviation] Am Heart Hosp J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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15. Vaz VD, Abizaid AC, Abizaid AA, Feres F, Staico R, Mattos LA, Pinto I, Tanajura LF, Sousa AG, Sousa JE: The usefulness of intracoronary ultrasound in the treatment decision-making of patients with ambiguous lesions in the left main coronary artery. Arq Bras Cardiol; 2006 Dec;87(6):681-7
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  • [Title] The usefulness of intracoronary ultrasound in the treatment decision-making of patients with ambiguous lesions in the left main coronary artery.
  • OBJECTIVE: To evaluate the safety and efficacy of surgical treatment approach vs. conservative approach in patients with ambiguous lesions in the left main coronary artery (LMCA), based on intracoronary ultrasound (ICUS) findings.
  • CONCLUSION: Treatment decision-making of patients with ambiguous lesions in the LMCA guided by ICUS findings showed to be safe and effective.
  • [MeSH-major] Coronary Artery Disease / therapy. Coronary Artery Disease / ultrasonography. Myocardial Revascularization. Ultrasonography, Interventional


16. Berry C, Noble S, Ibrahim R, Grégoire J, Levesque S, L'allier PL, Tardif JC: Remodeling is a more important determinant of lumen size than atheroma burden in left main coronary artery disease. Am Heart J; 2010 Jul;160(1):188-194.e1
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  • [Title] Remodeling is a more important determinant of lumen size than atheroma burden in left main coronary artery disease.
  • BACKGROUND: Left main coronary artery (LMCA) disease influences survival; however, the predictors of LMCA changes over time are incompletely understood.
  • The IVUS measurements were first obtained at the smallest lumen area and the largest plaque area at follow-up and the corresponding positions in the LMCA were then measured at baseline.
  • RESULTS: The LMCA percentage of atheroma area at baseline was 38.2% +/- 11.8%, and 133 patients (64%) experienced an increase in percentage of atheroma area.
  • Although LMCA length correlated negatively with baseline lumen area and total vessel area, it did not correlate with their changes over time.
  • CONCLUSIONS: The LMCA lumen dimensions are more tightly linked with remodeling than with atheroma progression/regression.
  • [MeSH-major] Angioplasty, Balloon, Coronary / methods. Atherosclerosis / complications. Coronary Artery Disease / physiopathology. Recovery of Function
  • [MeSH-minor] Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Time Factors. Ultrasonography, Interventional

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20598991.001).
  • [ISSN] 1097-6744
  • [Journal-full-title] American heart journal
  • [ISO-abbreviation] Am. Heart J.
  • [Language] eng
  • [Grant] United Kingdom / British Heart Foundation / / ; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. Suemaru S, Iwasaki K, Yamamoto K, Kusachi S, Hina K, Hirohata S, Hirota M, Murakami M, Kamikawa S, Murakami T, Shiratori Y: Coronary pressure measurement to determine treatment strategy for equivocal left main coronary artery lesions. Heart Vessels; 2005 Nov;20(6):271-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coronary pressure measurement to determine treatment strategy for equivocal left main coronary artery lesions.
  • It is often hard to select a treatment strategy for equivocal left main coronary artery (LMCA) disease.
  • We investigated the usefulness of coronary pressure (CP) measurement for determining the treatment strategy in intermediate LMCA disease.
  • We measured CP in 15 consecutive patients with equivocal LMCA disease (age 67.6 +/- 7.5 years, 14 males).
  • Patients with FFRmyo > or = 0.75 and <0.75 received medical therapy and coronary artery bypass grafting (CABG), respectively, and were followed up for 32.5 +/- 9.7 (20-47) months.
  • FFRmyo of the LMCA was 0.91 +/- 0.01 and 0.61 +/- 0.03 in patients who received medical and surgical therapy, respectively.
  • During the follow-up period, no patients with medical therapy showed symptoms due to the LMCA lesion.
  • In conclusion, the present results clearly demonstrated that CP is clinically useful for determining the treatment strategy for equivocal LMCA lesions but coronary angiography is not.
  • [MeSH-major] Blood Pressure / physiology. Coronary Artery Disease / diagnosis. Coronary Circulation / physiology. Coronary Stenosis / diagnosis. Myocardial Infarction / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blood Flow Velocity / physiology. Cardiac Catheterization. Coronary Artery Bypass. Coronary Vessels / physiopathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications / diagnosis. Postoperative Complications / physiopathology. Regional Blood Flow / physiology

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  • (PMID = 16314909.001).
  • [ISSN] 0910-8327
  • [Journal-full-title] Heart and vessels
  • [ISO-abbreviation] Heart Vessels
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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18. Fend F, Horn T, Koch I, Vela T, Orazi A: Atypical chronic myeloid leukemia as defined in the WHO classification is a JAK2 V617F negative neoplasm. Leuk Res; 2008 Dec;32(12):1931-5
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  • [Title] Atypical chronic myeloid leukemia as defined in the WHO classification is a JAK2 V617F negative neoplasm.
  • Atypical chronic myeloid leukemia (aCML) as defined by the WHO classification is a rare hematopoietic stem cell disorder, which shows both myeloproliferative as well as myelodysplastic features.
  • Because of the presence of neutrophilic leukocytosis, aCML may resemble chronic myelogenous leukemia.
  • However, in contrast with the latter, aCML lacks a Philadelphia chromosome or the BCR/ABL fusion gene.
  • The molecular pathogenesis of aCML and its relationship to other myeloproliferative neoplasms is unknown.
  • Fifty-nine cases of Philadelphia (Ph) chromosome negative chronic myeloproliferative neoplasms (CMPN) and normal bone marrows (BM) served as controls.
  • None of the nine amplifiable cases of aCML and none of the normal BM controls showed a JAK2 V617F mutation, in contrast to 45/59 (76%) of the Ph chromosome negative CMPN cases.
  • Atypical CML should therefore be considered as a JAK2 negative chronic myeloid neoplasm that remains properly categorized, alongside chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, within the WHO group of myelodysplastic/myeloproliferative neoplasms.
  • [MeSH-major] Amino Acid Substitution. Janus Kinase 2 / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / classification. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics
  • [MeSH-minor] Blast Crisis / blood. Blast Crisis / pathology. Blood Cell Count. Fusion Proteins, bcr-abl / genetics. Humans. Mastocytosis / pathology. Neutrophils / pathology. Philadelphia Chromosome. World Health Organization


19. Hamzeh RK, El-Said HG, Moore JW: Left main coronary artery compression from right pulmonary artery stenting. Catheter Cardiovasc Interv; 2009 Feb 1;73(2):197-202
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  • [Title] Left main coronary artery compression from right pulmonary artery stenting.
  • Complications related to pulmonary artery stenting include stent migration, jailing of vessels, vessel rupture, and compression of surrounding structures.
  • Compression of the left main coronary artery (LMCA) as a result of stent placement in the right pulmonary artery (RPA) is extremely rare.
  • We present two patients post repair of congenital heart disease who suffered LMCA compression following RPA stenting.
  • The first patient experienced acute coronary insufficiency in the cardiac catheterization laboratory, whereas the second patient had a more chronic course.
  • We also present a third patient who had a CT angiogram that demonstrated a close spatial relationship between the RPA and the LMCA.
  • Based on our previous experiences, we felt that this patient was at significant risk for LMCA compression if the RPA were stented.
  • Coronary compression is rare complication of pulmonary artery stenting but should be considered in cases with history of repaired congenital heart disease.
  • [MeSH-major] Angioplasty, Balloon. Coronary Stenosis / etiology. Heart Defects, Congenital / therapy. Pulmonary Artery. Stents

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • [CommentIn] Catheter Cardiovasc Interv. 2009 Feb 1;73(2):203-4 [19156880.001]
  • (PMID = 19156890.001).
  • [ISSN] 1522-726X
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Jönsson A, Hammar N, Liska J, Nordqvist T, Ivert T: High mortality after coronary bypass surgery in patients with high-grade left main coronary artery stenosis. Scand Cardiovasc J; 2006 Jun;40(3):179-85
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  • [Title] High mortality after coronary bypass surgery in patients with high-grade left main coronary artery stenosis.
  • OBJECTIVE: To determine mortality after coronary artery bypass grafting (CABG) in relation to degree of left main coronary artery (LMCA) obstruction.
  • DESIGN: All patients without LMCA stenosis (n=3370), with low-grade stenosis (n = 261), high-grade stenosis (n = 224) or total occlusion of the LMCA (n = 15) were followed for ten years after CABG performed during 1970-1989.
  • RESULTS: Early mortality was 1.9% and 2.3%, respectively, if there was no or a low-grade LMCA stenosis vs. 6.3% if the stenosis was high-grade.
  • Ten-year survival was 76% if no LMCA obstruction, 74% if low-grade stenosis and 64% if the stenosis was high-grade.
  • Risk of early death (odds ratio 2.6, 95% CI 1.4-4.8) and mortality at ten years (relative risk 1.5, 95% CI 1.1-2.0) was higher in patients with high-grade stenosis than in those without LMCA stenosis.
  • There was no increased long-term mortality in patients with low-grade stenosis or among the few patients with occlusion of the LMCA.
  • CONCLUSIONS: High-grade LMCA stenosis was associated with a three-fold increased risk of early and fifty percent higher risk of late death than in patients without LMCA stenosis.
  • [MeSH-minor] Aged. Coronary Artery Bypass. Female. Humans. Male. Middle Aged. Time Factors

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  • (PMID = 16798666.001).
  • [ISSN] 1401-7431
  • [Journal-full-title] Scandinavian cardiovascular journal : SCJ
  • [ISO-abbreviation] Scand. Cardiovasc. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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21. Aygul N, Salamov E, Dogan U, Tokac M: Acute occlusion of the left main trunk presenting as ST-elevation acute coronary syndrome. J Electrocardiol; 2010 Jan-Feb;43(1):76-8
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  • [Title] Acute occlusion of the left main trunk presenting as ST-elevation acute coronary syndrome.
  • Acute obstruction of the left main coronary artery (LMCA) is not frequently encountered.
  • Electrocardiographic findings are important to early diagnosis in determining an acute obstruction of the LMCA, which requires immediate aggressive treatment, in this extremely unstable condition.
  • However, there is no single typical electrocardiographic pattern representing acute occlusion of the LMCA.
  • We describe a rare electrocardiographic finding that suggested ST-elevation acute coronary syndrome of the anterior zone due to left main trunk total occlusion.
  • [MeSH-major] Acute Coronary Syndrome / diagnosis. Acute Coronary Syndrome / etiology. Coronary Stenosis / complications. Coronary Stenosis / diagnosis. Electrocardiography / methods
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 19698952.001).
  • [ISSN] 1532-8430
  • [Journal-full-title] Journal of electrocardiology
  • [ISO-abbreviation] J Electrocardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Madias JE: Exercise-attenuation of Q-waves in II, III, and aVF, and R-Waves in V1 and V2 in a patient with an inferior infarction and anterior wall ischemia. Pacing Clin Electrophysiol; 2008 Nov;31(11):1508-12
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  • Myocardial scintigraphy disclosed ischemia of the anterior wall and coronary arteriography, a 90% stenosis of the left main coronary artery (LMCA).
  • This electrocardiogram sign is diagnostic of severe anterior wall ischemia due to left anterior descending or LMCA stenosis.
  • [MeSH-major] Coronary Stenosis / diagnosis. Coronary Stenosis / etiology. Electrocardiography / methods. Myocardial Infarction / complications. Myocardial Infarction / diagnosis. Ventricular Dysfunction, Left / complications. Ventricular Dysfunction, Left / diagnosis

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  • (PMID = 18950310.001).
  • [ISSN] 1540-8159
  • [Journal-full-title] Pacing and clinical electrophysiology : PACE
  • [ISO-abbreviation] Pacing Clin Electrophysiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Lane SW, Fairbairn DJ, McCarthy C, Nandini A, Perry-Keene J, Kennedy GA: Leukaemia cutis in atypical chronic myeloid leukaemia with a t(9;22) (p24;q11.2) leading to BCR-JAK2 fusion. Br J Haematol; 2008 Aug;142(4):503
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  • [Title] Leukaemia cutis in atypical chronic myeloid leukaemia with a t(9;22) (p24;q11.2) leading to BCR-JAK2 fusion.
  • [MeSH-major] Chromosomes, Human, Pair 22 / genetics. Chromosomes, Human, Pair 9 / genetics. Janus Kinase 2 / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Skin Neoplasms / genetics. Translocation, Genetic

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  • (PMID = 18537978.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2
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24. Radojkovic M, Ristic S, Pavlovic S, Colovic M: Molecular response to imatinib in patient with Ph negative p190 BCR-ABL transcript positive chronic myeloid leukemia with cyclic leukocytosis. Leuk Res; 2009 Jun;33(6):e10-2
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  • [Title] Molecular response to imatinib in patient with Ph negative p190 BCR-ABL transcript positive chronic myeloid leukemia with cyclic leukocytosis.
  • An atypical case of Philadelphia (Ph) negative, e1a2 BCR-ABL transcript positive chronic myeloid leukemia (CML) characterized with cyclic periodic leukocytosis and spontaneous remissions is reported.
  • So far, only few Ph positive CML patients expressing p190 BCR-ABL protein and different clinical characteristics and treatment have been described in the literature.
  • This is the first report of Philadelphia negative, p190 BCR-ABL positive CML with cyclic spontaneous oscillation of white blood cell count (WBC), and excellent response to imatinib treatment.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Genes, abl. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukocytosis. Piperazines / therapeutic use. Pyrimidines / therapeutic use. RNA, Messenger / genetics


25. Ripsweden J, Brismar TB, Holm J, Melinder A, Mir-Akbari H, Nilsson T, Nyman U, Rasmussen E, Rück A, Cederlund K: Impact on image quality and radiation exposure in coronary CT angiography: 100 kVp versus 120 kVp. Acta Radiol; 2010 Oct;51(8):903-9
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  • MATERIAL AND METHODS: Patients referred for evaluation of suspected coronary artery disease (CAD) underwent 64-channel detector CCTA using a tube voltage of either 120 kVp (n = 46) or 100 kVp (n = 82).
  • Vascular density and image noise were quantified in the left main coronary artery (LMCA) and proximal ascending aorta (AA).
  • RESULTS: Mean values in the 100/120 kVp cohorts regarding CNR in the LMCA were 12.7/16.0 (P<0.0001)) and in the AA 13.2/17.2 (P<0.0001), CTDI(vol) 34.4/57.4 mGy (a 40% reduction, P<0.0001), DLP 578/1125 mGy × cm (P<0.0001), and estimated effective dose 9.6/20.2 mSv (P<0.0001).
  • CONCLUSION: By reduction of tube voltage from 120 to 100 kVp at CCTA, while keeping all other scanning parameters unchanged, the radiation dose to the patient can be almost halved while keeping the diagnostic image quality at a clinically acceptable level.
  • [MeSH-minor] Aged. Coronary Artery Disease / radiography. Female. Humans. Male. Middle Aged. Neoplasms, Radiation-Induced / prevention & control. Prospective Studies. Radiation Protection

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  • (PMID = 20735275.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Arkowski J, Derkacz A, Negrusz-Kawecka M, Poczatek K, Nowicki P, Obremska M, Sciborski R, Mazurek W: [Life saving angioplasty of left main coronary artery in a high risk patient]. Kardiol Pol; 2006 Oct;64(10):1121-4; discussion 1125
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  • [Title] [Life saving angioplasty of left main coronary artery in a high risk patient].
  • A case a of a life-saving angioplasty of left main coronary artery (LMCA) is presented.
  • Coronary angiography revealed significant stenosis of LMCA, in addition to previously known multi-vessel diffuse CAD.
  • In 9 month follow-up angiography there was no restenosis in LMCA.
  • In patients to whom cardiac surgery presents very high risk, an angioplasty of LMCA can be life-saving, with good long term effects.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy
  • [MeSH-minor] Aged. Coronary Angiography. Coronary Artery Bypass. Coronary Vessels / surgery. Critical Care / methods. Humans. Male. Stents. Treatment Outcome

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  • (PMID = 17089246.001).
  • [ISSN] 0022-9032
  • [Journal-full-title] Kardiologia polska
  • [ISO-abbreviation] Kardiol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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27. Moral S, Cardenas M, Puigfel M, Bassaganyas J: Subacute total occlusion of the left main coronary artery. Acta Cardiol; 2009 Jun;64(3):411
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  • [Title] Subacute total occlusion of the left main coronary artery.
  • Total occlusion of left main coronary artery (LMCA) is a rare manifestation of coronary atherosclerotic disease.
  • We report a patient with subacute total occlusion of the LMCA.
  • [MeSH-major] Coronary Artery Disease / diagnosis. Coronary Occlusion / diagnosis. Coronary Vessels / pathology

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  • (PMID = 19593955.001).
  • [ISSN] 0001-5385
  • [Journal-full-title] Acta cardiologica
  • [ISO-abbreviation] Acta Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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28. Ma YH, Cheng WZ, Gong F, Ma AL, Yu QW, Zhang JY, Hu CY, Chen XH, Zhang DQ: Active Chinese mistletoe lectin-55 enhances colon cancer surveillance through regulating innate and adaptive immune responses. World J Gastroenterol; 2008 Sep 14;14(34):5274-81
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  • AIM: To investigate the potential role of active Chinese mistletoe lectin-55 (ACML-55) in tumor immune surveillance.
  • The experimental treatment was orally administered with ACML-55 or PBS, followed by the inoculation of colon cancer cell line CT26.
  • RESULTS: Our results showed, compared to PBS treated mice, ACML-55 treatment significantly delayed colon cancer development in colon cancer-bearing Balb/c mice in vivo.
  • Treatment with ACML-55 enhanced both Ag specific activation and proliferation of CD4+ and CD8+ T cells, and increased the number of tumor Ag specific CD8+ T cells.
  • Interestingly, ACML-55 treatment also showed increased cell number of NK, and gammadeltaT cells, indicating the role of ACML-55 in activation of innate lymphocytes.
  • CONCLUSION: Our results demonstrate that ACML-55 therapy can enhance function in immune surveillance in colon cancer-bearing mice through regulating both innate and adaptive immune responses.
  • [MeSH-minor] Animals. CD4-Positive T-Lymphocytes / drug effects. CD4-Positive T-Lymphocytes / immunology. CD8-Positive T-Lymphocytes / drug effects. CD8-Positive T-Lymphocytes / immunology. Cell Line, Tumor. Disease Models, Animal. Female. Immunity, Innate / drug effects. Interferon-gamma / biosynthesis. Killer Cells, Natural / drug effects. Killer Cells, Natural / immunology. Lymphocyte Activation / drug effects. Male. Mice. Mice, Inbred BALB C. Monitoring, Immunologic. Phytotherapy

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  • (PMID = 18785279.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drugs, Chinese Herbal; 0 / Plant Lectins; 82115-62-6 / Interferon-gamma
  • [Other-IDs] NLM/ PMC2744057
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29. Mohan S, Sapra RR: Images in cardiology: dual LAD circulation. a rare coronary anomaly. Indian Heart J; 2010 Jul-Aug;62(4):367-8
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  • AIM: We report a case of type IV dual Left anterior descending (LAD) coronary artery detected incidentally in a female who presented with atypical chest pain.
  • METHOD: She underwent coronary angiography which showed dual LAD--one from the LMCA and another from right coronary sinus.
  • RESULTS: Coronary angiography helped in the diagnosis of the rare coronary anomaly.
  • CONCLUSIONS: The identification of anomalous coronary artery is important.

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  • (PMID = 21280486.001).
  • [ISSN] 0019-4832
  • [Journal-full-title] Indian heart journal
  • [ISO-abbreviation] Indian Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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30. Bonnin P, Debbabi H, Mariani J, Charriaut-Marlangue C, Renolleau S: Ultrasonic assessment of cerebral blood flow changes during ischemia-reperfusion in 7-day-old rats. Ultrasound Med Biol; 2008 Jun;34(6):913-22
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  • [Title] Ultrasonic assessment of cerebral blood flow changes during ischemia-reperfusion in 7-day-old rats.
  • It combines permanent occlusion of the distal left middle cerebral artery (LMCA) and transient occlusion of homolateral common carotid artery (LCCA).
  • In 10 rat pups, we measured blood flow velocities (BFV) in main cerebral arteries with 12-MHz ultrasound imaging.
  • At basal states, peak systolic BFV in proximal LMCA was 16.0 +/- 3.0 cm.s(-1).
  • Occlusion of LMCA did not yield significant modifications.
  • Indeed, LMCA was then supply by the right internal carotid and the vertebral arteries through the circle of Willis.
  • In three rat pups, release of occlusion of LCCA was followed by restoration of BFV in the left internal carotid artery and in LMCA, in seven pups, by a reversed flow in the LICA and lower BFV in LMCA (11.9 +/- 2.3, p < 0.05).
  • In addition, ultrasound imaging is a useful, reproducible, non invasive, easy-to-repeat, method to assess and monitor arterial cerebral blood flow supply in small animals.
  • It helps to characterize changes occurring during cerebral ischemia and reperfusion, particularly the depth of the hypoperfusion, as well as the variability of reflow.
  • In preclinical studies, this method could help to identify what can be assigned to a neuroprotective treatment and what depends on changes in cerebral blood flow supply.
  • [MeSH-major] Brain Ischemia / congenital. Brain Ischemia / ultrasonography. Middle Cerebral Artery / ultrasonography
  • [MeSH-minor] Animals. Animals, Newborn. Blood Flow Velocity. Carotid Artery Diseases / pathology. Carotid Artery, Common / pathology. Carotid Artery, Internal / ultrasonography. Female. Male. Models, Animal. Rats. Regional Blood Flow. Ultrasonography, Doppler, Pulsed

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  • (PMID = 18243494.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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31. Clemente A, Del Borrello M, Greco P, Mannella P, Di Gregorio F, Romano S, Morra A: Anomalous origin of the coronary arteries in children: diagnostic role of three-dimensional coronary MR angiography. Clin Imaging; 2010 Sep-Oct;34(5):337-43
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  • [Title] Anomalous origin of the coronary arteries in children: diagnostic role of three-dimensional coronary MR angiography.
  • When the anomalous origin of coronary arteries (AOCA) is suspected in children (especially athletes), due to signs and symptoms of myocardial ischemia or on the basis of echocardiographic assessment, three-dimensional coronary magnetic resonance angiography (3D-CMRA) can be proposed for the fine morphological evaluation of coronary branches anatomy and course.
  • AOCA was confirmed by 3D-CMRA in 8 out of 15 cases (53%) and three different anatomical variants were demonstrated, that is, ectopic origin of the left circumflex artery arising from the right coronary artery with retro-aortic course in four cases, single coronary artery arising from the right sinus of Valsalva with interarterial course in one case, ectopic right coronary artery arising from the left sinus of Valsalva with interarterial course in one case; in two patients without anomalies of origin of the coronary arteries, elongated LMCA with angulation of the proximal segment of the left circumflex artery was present.
  • When AOCA is suspected particularly in children (especially athletes), CMRA without the use of contrast medium is an effective diagnostic technique, which is useful to clarify the spatial position of the anomalous course of the main coronary branches in order to suggest the most convenient management of the disease.
  • [MeSH-major] Coronary Vessel Anomalies / diagnosis. Imaging, Three-Dimensional / methods. Magnetic Resonance Angiography / methods

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  • (PMID = 20813295.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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32. Murati A, Arnoulet C, Lafage-Pochitaloff M, Adélaide J, Derré M, Slama B, Delaval B, Popovici C, Vey N, Xerri L, Mozziconacci MJ, Boulat O, Sainty D, Birnbaum D, Chaffanet M: Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. Int J Oncol; 2005 Jun;26(6):1485-92
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  • [Title] Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion.
  • The case of a patient presenting with a myeloproliferative disorder (MPD) characterized by a t(8;22) (p12;q11) translocation was investigated.
  • The rearrangement resulted in the production of BCR-FGFR1 and FGFR1-BCR chimeric transcripts after in-frame fusions of BCR exon 4 with FGFR1 exon 9 and FGFR1 exon 8 with BCR exon 5, respectively.
  • The four previously reported patients with such translocation presented with an atypical chronic myeloid leukemia (CML) without Philadelphia chromosome.
  • The BCR-FGFR1 gene fusion was detected by dual-color fluorescence in situ hybridization in both CD19- and CD19+ populations.
  • In contrast to the other FGFR1-MPDs that show myeloid and T cell proliferation, we propose that this t(8;22) MPD is a myeloid and B cell disease, and potentially a novel type of hematological disease.
  • [MeSH-minor] Aged. Chromosomes, Human, Pair 22. Humans. Immunophenotyping. Male. Proto-Oncogene Proteins c-bcr. Receptor, Fibroblast Growth Factor, Type 1

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  • (PMID = 15870860.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Receptors, Fibroblast Growth Factor; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.11.1 / BCR protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr
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33. Wang L, Zhu K, Zha X, Chen S, Yang L, Chen S, Li Y: Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia. J Hematol Oncol; 2010;3:14
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  • [Title] Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia.
  • INTRODUCTION: The development of Philadelphia chromosome (Ph) negative acute leukemia/myelodysplastic syndrome (MDS) in patients with Ph-positive chronic myeloid leukemia (CML) is very rare.
  • The features of restrictive usage and absence of partial T cell clones have been found in patients with CML.
  • However, the T-cell clonal evolution of Ph-negative malignancies during treatment for CML is still unknown.
  • OBJECTIVE: To investigate the dynamic change of clonal proliferation of T cell receptor (TCR) Valpha and Vbeta subfamilies in one CML patient who developed Ph-negative acute lymphoblastic leukemia (ALL) after interferon and imatinib therapy.
  • METHODS: The peripheral blood mononuclear cells (PBMC) samples were collected at the 3 time points (diagnosis of Ph-positive chronic phase (CP) CML, developing Ph-negative ALL and post inductive chemotherapy (CT) for Ph-negative ALL, respectively).
  • RESULTS: The CML patient who achieved complete cytogenetic remission (CCR) after 5 years of IFN-alpha therapy suddenly developed Ph-negative ALL 6 months following switch to imatinib therapy.
  • The expression pattern and clonality of TCR Valpha/Vbeta T cells changed in different disease stages.
  • Additionally, there have been obvious differences in Valpha/Vbeta subfamily of T cells between the stages of Ph-positive CML-CP and Ph-negative ALL.
  • The Valpha10 and Vbeta3 T cells evolved from oligoclonality to polyclonality, the Vbeta13 T cells changed from bioclonality to polyclonality, when Ph-negative ALL developed.
  • CONCLUSIONS: Restrictive usage and clonal proliferation of different Valpha/Vbeta subfamily T cells between the stages of Ph-positive CP and Ph-negative ALL were detected in one patient.
  • These changes may play a role in Ph- negative leukemogenesis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Philadelphia Chromosome. Receptors, Antigen, T-Cell, alpha-beta / genetics. T-Lymphocytes / immunology


34. Li JJ, Xu B, Chen JL: Stenting for left main coronary artery occlusion in adolescent: A case report. World J Cardiol; 2010 Jul 26;2(7):211-4
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  • [Title] Stenting for left main coronary artery occlusion in adolescent: A case report.
  • Acute total or subtotal occlusion of left main coronary artery (LMCA) is a catastrophic and mostly fatal event.
  • Survival is strongly dependent on the presence of collateral blood flow to the left coronary artery or a dominant right coronary artery, and emergency intervention for preserving the left ventricular function.
  • Here, we present a case of a 14-year-old boy with subtotal occlusion of the LMCA accompanying acute myocardial infarction probably caused by congenital syphilis according to his positive serum syphilis antibody.
  • His survival was closely associated with a dominant right coronary artery and timely thrombolytic therapy.

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  • (PMID = 21160753.001).
  • [ISSN] 1949-8462
  • [Journal-full-title] World journal of cardiology
  • [ISO-abbreviation] World J Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999056
  • [Keywords] NOTNLM ; Acute myocardial infarction / Adolescent / Left main coronary artery / Paclitaxel-eluting stent
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35. Okmen AS: Left main coronary artery stenosis associated with extremely long fusiform aneurysm. Int J Cardiol; 2007 Sep 14;121(1):97-9
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  • [Title] Left main coronary artery stenosis associated with extremely long fusiform aneurysm.
  • Coronary artery aneurysm is defined as coronary dilatation, which exceeds the diameter of normal adjacent segment or the diameter of the patient's largest coronary vessel by 1.5 times [Syed M, Lesch M: Coronary artery aneurysms: a review.
  • Coronary artery aneurysm: an unusual case report and a review of the literature.
  • Left main coronary aneurysms (LMCA) are even more rare; in a study by involving 22,000 coronary angiograms an occurrence rate of 0.1% has been found [Topaz O, DiSciascio G, Cowley MJ, Goudreau E, Soffer A, Nath A et al.
  • Angiographic features of left main coronary artery aneurysms.
  • This report details the exceptional case of a 62-year-old patient with "unusually long fusiform" aneurysm of the left main coronary artery associated with critical left main coronary artery distal stenosis involving the ostia of left anterior descending and left circumflex coronary artery.
  • [MeSH-minor] Coronary Angiography. Coronary Artery Bypass. Coronary Artery Disease / complications. Coronary Artery Disease / radiography. Coronary Artery Disease / surgery. Humans. Male. Middle Aged

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  • (PMID = 17107722.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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36. Desai RV, Gupta R, Litovsky SH, Nath H, Gupta H, Singh SP, Evanochko WT, Knobloch JE, Lloyd SG: X-ray angiography and magnetic resonance imaging to distinguish interarterial from septal courses of anomalous left coronary artery: an ex vivo heart model. J Invasive Cardiol; 2009 Dec;21(12):648-52
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  • [Title] X-ray angiography and magnetic resonance imaging to distinguish interarterial from septal courses of anomalous left coronary artery: an ex vivo heart model.
  • OBJECTIVE: We sought to demonstrate the distinguishing features between interarterial and intraseptal courses of an anomalous left coronary artery from the right sinus of Valsalva (RSV) on X-ray angiography, using an ex vivo model.
  • BACKGROUND: An anomalous left main coronary artery (LMCA) arising from the RSV can take prepulmonary, retro-aortic, interarterial (IA) or intraseptal (IS) courses, of which only the IA course is associated with sudden death.
  • Anomalous LMCA is usually identified during catheter angiography.
  • RESULTS: In a normally formed heart, an anomalous LMCA with IA path must take a cephalad course, superior to the pulmonary valve.
  • CONCLUSIONS: X-ray angiography can differentiate IA and IS courses of an anomalous LMCA in the normally formed heart.

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  • (PMID = 19966369.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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37. Tefferi A, Gilliland DG: JAK2 in myeloproliferative disorders is not just another kinase. Cell Cycle; 2005 Aug;4(8):1053-6
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  • Myeloproliferative disorders (MPD) represent a subcategory of hematological malignancies and are characterized by a stem cell-derived clonal proliferation of myeloid cells including erythrocytes, platelets, and leucocytes.
  • Traditionally, the term 'MPD' included chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis with myeloid metaplasia (MMM).
  • At present, these four disorders are referred to as 'classic' MPD and are distinguished from a spectrum of other MPD-like clinicopathologic entities that are operationally classified as 'atypical' MPD.
  • The oncogenic mutations(s) in classic MPD are unknown except for CML, which is associated with an activating mutation (Bcr/Abl) of the gene encoding for the Abl cytoplasmic protein kinase (PTK).
  • The same mutation was also found in a small number of patients with either atypical MPD or the myelodysplastic syndrome but not in normal controls, germline tissue including T lymphocytes, and patients with secondary erythrocytosis.
  • Taken together, these observations suggest that JAK2(V617F) is an acquired myeloid lineage-specific mutation that engenders a pathogenetic relevance for the PV phenotype in MPD.

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  • (PMID = 15970705.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 11096-26-7 / Erythropoietin; 42HK56048U / Tyrosine; 9007-49-2 / DNA; EC 2.7.- / Phosphotransferases; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Jak2 protein, mouse; EC 2.7.10.2 / Janus Kinase 2
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38. Orazi A, Chiu R, O'Malley DP, Czader M, Allen SL, An C, Vance GH: Chronic myelomonocytic leukemia: The role of bone marrow biopsy immunohistology. Mod Pathol; 2006 Dec;19(12):1536-45
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  • [Title] Chronic myelomonocytic leukemia: The role of bone marrow biopsy immunohistology.
  • The World Health Organization criteria for diagnosing chronic myelomonocytic leukemia (CMML) are largely based on findings observed in the peripheral blood and bone marrow aspirate.
  • We examined whether bone marrow biopsy supplemented by immunohistochemistry may be helpful in distinguishing CMML from cases of chronic myelogenous leukemia and atypical chronic myeloid leukemia (aCML).
  • We immunostained 25 cases of CMML with paraffin reactive antibodies which included CD68 (KP1), CD68R (PG-M1), and CD163, and compared the results with those observed in six cases of chronic myelogenous leukemia and in three cases of atypical CML.
  • In addition, we examined whether CD34 immunohistochemistry could be useful in separating cases of CMML with less than 10% blasts (type-1) from cases of CMML with blasts accounting for 10-19% (type-2), and cases of CMML in acute transformation to acute myeloid leukemia (blasts > or = 20%).
  • CD123-positive plasmacytoid monocyte nodules were found only in CMML and not in the other two disease groups.
  • CD68R was more restricted to bone marrow macrophages and monocytes than CD68, but the differences between CMML and chronic myelogenous leukemia or atypical CML were still not significant.
  • Although CD42b immunostaining facilitated the detection of dwarf megakaryocytes often present in CMML, the distinction between those and the small forms seen in chronic myelogenous leukemia was still problematic.
  • [MeSH-major] Biopsy, Needle. Bone Marrow / pathology. Immunoenzyme Techniques / methods. Leukemia, Myelomonocytic, Chronic / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / metabolism. Biomarkers, Tumor / metabolism. Bone Marrow Cells / metabolism. Bone Marrow Cells / pathology. Diagnosis, Differential. Female. Humans. Karyotyping. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Male. Megakaryocytes / metabolism. Megakaryocytes / pathology. Middle Aged

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  • (PMID = 17041567.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor
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39. Lim TH, Tien SL, Lim P, Lim AS: The incidence and patterns of BCR/ABL rearrangements in chronic myeloid leukaemia (CML) using fluorescence in situ hybridisation (FISH). Ann Acad Med Singapore; 2005 Oct;34(9):533-8
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  • [Title] The incidence and patterns of BCR/ABL rearrangements in chronic myeloid leukaemia (CML) using fluorescence in situ hybridisation (FISH).
  • INTRODUCTION: Chronic myeloid leukaemia (CML) is characterised by the formation of the BCR/ABL fusion gene, usually as a result of the Philadelphia (Ph) translocation between chromosomes 9 and 22.
  • MATERIALS AND METHODS: The incidence of both typical and atypical BCR/ ABL gene rearrangements was determined in 110 patients suspected of CML using dual fusion fluorescence in situ hybridisation (DF-FISH) probes.
  • RESULTS: Eighty-seven per cent of CML patients showed Ph translocation while 13% were negative for the Ph chromosome.
  • About 71.9% of Ph-positive patients displayed the typical DF-FISH signal pattern.
  • Atypical patterns among the Ph-positive patients included the concurrent loss of residual proximal 9q and distal 22q (10.4%), complex translocation with additional partners (9.4%), supernumerary Ph (3.1%), loss of residual 9q sequences proximal to breakpoint (3.1%), and deletion of distal derivative 22q signal (2.1%).
  • Cryptic genetic alterations with loss of proximal 9q sequences were found in 13.5% of CML Ph-positive patients, which is associated with poor prognosis.
  • Fusion signals were detected in 57.1% of CML Ph-negative patients, indicating cryptic BCR/ABL rearrangements (i.e., masked Ph).
  • CONCLUSION: FISH is able to detect BCR/ABL fusion in CML with masked or variant Ph not apparent with conventional karyotyping.
  • Establishment of signal patterns with FISH is important as atypical patterns may have clinical prognostic implications.
  • [MeSH-major] Gene Rearrangement. Genes, abl / genetics. In Situ Hybridization, Fluorescence. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics

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  • (PMID = 16284673.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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40. Slim A, Thurlow J, Blevins J, Martinho S, Markelz B: Discovery of a symptomatic left anomalous coronary artery from the opposite sinus and postoperative considerations. Case Rep Med; 2009;2009:509064
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  • [Title] Discovery of a symptomatic left anomalous coronary artery from the opposite sinus and postoperative considerations.
  • This is the case of an 18 year old active duty soldier with symptoms of exertional chest pressure and syncope who was found to have anomalous origin of the left main coronary artery (LMCA) from the right coronary cusp (RCC) traveling partially between the great vessels before taking a septal approach between the left ventricular outflow tract (LVOT) and the right ventricular outflow tract (RVOT).
  • Anomalous origin of coronary arteries is a rare condition that carries an increased risk of angina, myocardial ischemia, and sudden cardiac death (SCD).

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  • [Cites] J Am Coll Cardiol. 2000 May;35(6):1493-501 [10807452.001]
  • [Cites] J Am Coll Cardiol. 2007 Nov 20;50(21):2078-82 [18021877.001]
  • [Cites] J Thorac Cardiovasc Surg. 2009 Feb;137(2):380-4 [19185157.001]
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  • (PMID = 19841756.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2762240
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41. Grand FH, Hidalgo-Curtis CE, Ernst T, Zoi K, Zoi C, McGuire C, Kreil S, Jones A, Score J, Metzgeroth G, Oscier D, Hall A, Brandts C, Serve H, Reiter A, Chase AJ, Cross NC: Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood; 2009 Jun 11;113(24):6182-92
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  • To help identify novel mutations in myeloproliferative neoplasms (MPNs), we performed a genome-wide single nucleotide polymorphism (SNP) screen to identify aUPD in 58 patients with atypical chronic myeloid leukemia (aCML; n = 30), JAK2 mutation-negative myelofibrosis (MF; n = 18), or JAK2 mutation-negative polycythemia vera (PV; n = 10).
  • Stretches of homozygous, copy neutral SNP calls greater than 20Mb were seen in 10 (33%) aCML and 1 (6%) MF, but were absent in PV.
  • In total, 7 different chromosomes were involved with 7q and 11q each affected in 10% of aCML cases.
  • CBL mutations were identified in all 3 cases with 11q aUPD and analysis of 574 additional MPNs revealed a total of 27 CBL variants in 26 patients with aCML, myelofibrosis or chronic myelomonocytic leukemia.
  • We conclude that acquired, transforming CBL mutations are a novel and widespread pathogenetic abnormality in morphologically related, clinically aggressive MPNs.
  • [MeSH-minor] Alternative Splicing. Amino Acid Sequence. Genome, Human. Genome-Wide Association Study. Humans. Janus Kinase 2 / genetics. Janus Kinase 2 / metabolism. Microsatellite Repeats. Molecular Sequence Data. Myeloid Cells / metabolism. Myeloid Cells / pathology. Prognosis. Sequence Homology, Amino Acid. Survival Rate. fms-Like Tyrosine Kinase 3 / antagonists & inhibitors. fms-Like Tyrosine Kinase 3 / genetics. fms-Like Tyrosine Kinase 3 / metabolism

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  • (PMID = 19387008.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / FLT3 protein, human; EC 2.7.10.1 / fms-Like Tyrosine Kinase 3; EC 2.7.10.2 / Janus Kinase 2; EC 6.3.2.- / CBL protein, human; EC 6.3.2.- / Proto-Oncogene Proteins c-cbl
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42. Oduncu V, Erkol A, Tanboğa IH, Kırma C: Late bare metal stent thrombosis. Turk Kardiyol Dern Ars; 2010 Sep;38(6):422-5
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  • We report on a 72-year-old male patient who developed late thrombosis of a bare metal stent implanted in the left main coronary artery (LMCA).
  • Following the first balloon predilatation of the lesion, a flow in the LMCA was observed, but there was no flow in the left anterior descending (LAD) artery.
  • Angiography of the right coronary artery demonstrated 90% stenosis at the same location which had been observed as a noncritical lesion during the first percutaneous coronary intervention.
  • As the patient was in shock, the right coronary artery was also stented and TIMI 3 flow was obtained.

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  • (PMID = 21200123.001).
  • [ISSN] 1016-5169
  • [Journal-full-title] Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
  • [ISO-abbreviation] Turk Kardiyol Dern Ars
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Platelet Aggregation Inhibitors; R16CO5Y76E / Aspirin
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43. Soulis JV, Farmakis TM, Giannoglou GD, Louridas GE: Wall shear stress in normal left coronary artery tree. J Biomech; 2006;39(4):742-9
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  • [Title] Wall shear stress in normal left coronary artery tree.
  • Despite the fact that the role of wall shear stress (WSS) as a local mechanical factor in atherogenesis is well established, its distribution over the entire normal human left coronary artery (LCA) tree has not yet been studied.
  • The LCA tree includes the left main coronary artery (LMCA), the left anterior descending (LAD), the left circumflex artery (LCxA) and their major branches.
  • On the LMCA bifurcation, at regions opposite to the flow divider, dominant low WSS values occur ranging from 0.75 to 2.25 N/m2.
  • [MeSH-major] Coronary Artery Disease / physiopathology. Coronary Vessels / physiopathology

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  • (PMID = 16439244.001).
  • [ISSN] 0021-9290
  • [Journal-full-title] Journal of biomechanics
  • [ISO-abbreviation] J Biomech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Polewczyk A, Janion M, Gutkowski W, Sielski J, Dudek D, Sadowski J, Sledź J, Jedrzejczak-Misiek M, Buda S: [Clinical evaluation, diagnostic and therapeutic approach to patients with left main coronary artery stenosis]. Pol Arch Med Wewn; 2006 Sep;116(3):861-7
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  • [Title] [Clinical evaluation, diagnostic and therapeutic approach to patients with left main coronary artery stenosis].
  • BACKGROUND: A critical stenosis of the left main coronary artery (LMCA) needs immediate diagnosis and therapy because of poor prognosis due to significant decrease of myocardial perfusion.
  • AIM: To identify patients with a critical stenosis of LMCA using clinical, biochemical electrocardiographic and echocardiographic data.
  • METHODS: Consecutive 75 subjects with angiographic result of culprit lesion in LMCA were selected.
  • Coronary artery disease risk factors, resting and exercise ECG changes, regional contractility defects in echocardiography and applied therapy were analysed.
  • RESULTS: A coexistence of critical LMCA narrowing and sclerotic changes in remaining coronary arteries were present in 93.3% of patients with predilection to the left anterior descending artery (65.3%).
  • An ST segment elevation in aVR lead in resting ECG was correlated with LMCA stenosis in 54.7% of patients.
  • Coronary artery by-pass grafting and resulted in good 1.5-years clinical outcome.
  • Patients with LMCA stenosis usually have disseminated sclerotic changes in coronary arteries.
  • 2. Evaluation of resting ECG with emphasis on ST elevation in aVR lead may be useful to predict LMCA stenosis.
  • 3. Further studies are required to define factors identifying patients with LMCA disease.
  • [MeSH-major] Coronary Stenosis / diagnosis

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  • (PMID = 18652279.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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45. Xubo G, Xingguo L, Xianguo W, Rongzhen X, Xibin X, Lin W, Lei Z, Xiaohong Z, Genbo X, Xiaoying Z: The role of peripheral blood, bone marrow aspirate and especially bone marrow trephine biopsy in distinguishing atypical chronic myeloid leukemia from chronic granulocytic leukemia and chronic myelomonocytic leukemia. Eur J Haematol; 2009 Oct;83(4):292-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of peripheral blood, bone marrow aspirate and especially bone marrow trephine biopsy in distinguishing atypical chronic myeloid leukemia from chronic granulocytic leukemia and chronic myelomonocytic leukemia.
  • OBJECTIVES: To better realize the features of peripheral blood (PB), bone marrow (BM) aspirate and especially BM trephine biopsy in atypical chronic myeloid leukemia (aCML).
  • METHODS: We studied PB, BM smears in 35 cases of aCML and compared with 84 cases of chronic granulocytic leukemia chronic phase (CGL-CP), 39 cases of chronic myelomonocytic leukemia (CMML).
  • In addition, we evaluated characteristics of BM trephine biopsies in 21 cases of aCML and compared with 68 cases of CGL-CP, 20 cases of CMML.
  • RESULTS: All aCML patients presented with leukocytosis (median WBC 17.3 x 10(9)/L), 48% had moderate anemia, and 85% had thrombocytopenia.
  • Values of monocytes, eosinophils, basophils, percentage of immature granulocytes and monocytes (0.63 +/- 0.41 x 10(9)/L, 0.18 +/- 0.16 x 10(9)/L, 0.09 +/-0.08 x 10(9)/L, 6.27 +/- 3.09%, and 2.46 +/- 1.75%, respectively) were useful in distinguishing aCML from CGL-CP and CMML groups.
  • The BM smears showed that striking dysgranulopoieis (100%), dyserythropoiesis (48.6%), percentage of blasts, nucleated erythrocytes, monocytes, eosinophils, and basophils (2.45 +/- 2.06%, 7.76 +/- 2.89%, 1.30 +/- 1.21%, 1.47 +/- 1.60%, and 1.15 +/- 1.08%, respectively) were all important parameters for a diagnosis of aCML.
  • On BM trephine sections, aCML was characterized as hypercellularity, a moderate degree of reticulin fibrosis (71.4%), lymphocytopenia (76.2%), plasmacytopenia (90.5%), abnormal localization of immature precursors (28.5%), and absence of eosinophilia, basophilia, monocytosis.
  • CONCLUSIONS: Besides the findings observed in PB and BM aspirate, features of BM trephine biopsy (including BM trephine section, BM imprint, immunohistochemical, and cytochemical staining) can also aid in the diagnosis of aCML.
  • [MeSH-major] Blood Cells / pathology. Bone Marrow / pathology. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy. Bone Marrow Examination. Diagnosis, Differential. Female. Histocytochemistry. Humans. Immunohistochemistry. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Leukemia, Myelomonocytic, Chronic / diagnosis. Male. Middle Aged


46. Valgimigli M, Malagutti P, Rodriguez-Granillo GA, Garcia-Garcia HM, Polad J, Tsuchida K, Regar E, Van der Giessen WJ, de Jaegere P, De Feyter P, Serruys PW: Distal left main coronary disease is a major predictor of outcome in patients undergoing percutaneous intervention in the drug-eluting stent era: an integrated clinical and angiographic analysis based on the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) and Taxus-Stent Evaluated At Rotterdam Cardiology Hospital (T-SEARCH) registries. J Am Coll Cardiol; 2006 Apr 18;47(8):1530-7
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  • [Title] Distal left main coronary disease is a major predictor of outcome in patients undergoing percutaneous intervention in the drug-eluting stent era: an integrated clinical and angiographic analysis based on the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) and Taxus-Stent Evaluated At Rotterdam Cardiology Hospital (T-SEARCH) registries.
  • OBJECTIVES: This study sought to investigate whether the anatomical location of the disease carries prognostic implications in patients undergoing drug-eluting stent (DES) implantation for the left main coronary artery (LMCA) stenosis.
  • BACKGROUND: Liberal use of DES, compared with a bare metal stent (BMS), has resulted in an improved outcome in patients undergoing LMCA intervention.
  • METHODS: From April 2002 to June 2004, 130 patients received DES as part of the percutaneous intervention for LMCA stenoses in our institution.
  • Distal LMCA disease (DLMD) was present in 94 patients.
  • They were at higher surgical risk and presented with a greater coronary disease extent compared with patients without DLMD.
  • CONCLUSIONS: Distal LMCA disease carries independent prognostic implications, and it may help in selecting the most appropriate patient subset for LMCA intervention beyond the conventional surgical risk status in the DES era.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Angiography. Coronary Disease / radiography. Coronary Disease / therapy. Paclitaxel / administration & dosage. Sirolimus / administration & dosage. Stents

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  • (PMID = 16630987.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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47. Kamakari S, Roussou A, Jefferson A, Ragoussis I, Anagnou NP: Structural analysis and expression profile of a novel gene on chromosome 5q23 encoding a Golgi-associated protein with six splice variants, and involved within the 5q deletion of a Ph(-) CML patient. Leuk Res; 2005 Jan;29(1):17-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Structural analysis and expression profile of a novel gene on chromosome 5q23 encoding a Golgi-associated protein with six splice variants, and involved within the 5q deletion of a Ph(-) CML patient.
  • In addition, the novel gene and other key regulatory genes of the region, such IL3, Ril, AF5q31 and TCF-1, were found to be deleted in an atypical CML case, thus underscoring the significance of this subregion in the leukemogenesis process.
  • [MeSH-major] Alternative Splicing. Carrier Proteins / genetics. Chromosomes, Human, Pair 5. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Amino Acid Sequence. Base Sequence. Chromosome Deletion. Gene Expression. Humans. Microfilament Proteins. Molecular Sequence Data

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  • (PMID = 15541471.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / GABARAPL2 protein, human; 0 / Microfilament Proteins
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48. Kreil S, Pfirrmann M, Haferlach C, Waghorn K, Chase A, Hehlmann R, Reiter A, Hochhaus A, Cross NC, German Chronic Myelogenous Leukemia (CML) Study Group: Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia. Blood; 2007 Aug 15;110(4):1283-90
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  • [Title] Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia.
  • Derivative chromosome 9 deletions are seen in 10% to 15% of patients with chronic myelogenous leukemia and have been associated with a poor prognosis; however, no studies have been performed in the context of a randomized clinical trial.
  • We developed a DNA-based deletion screen and investigated 339 chronic phase patients treated with interferon-alpha as first-line therapy in 3 controlled German studies with a median observation time of 7 years.
  • Of these, 21 spanned the ABL/BCR junction and 38 were centromeric (n = 20) or telomeric (n = 18) of the breakpoint.
  • Patients with breakpoint-spanning deletions had poorer survival compared with patients without deletions (4.7 versus 7.8 years; P = .003), but this was not significant when censored at allogeneic stem cell transplantation (n = 129) or imatinib (n = 62) treatment in the first chronic phase (P = .078).
  • Multiple Cox regression analysis indicated that deletion status (P = .007), age (P = .018), and spleen enlargement (P < .001) were significant independent indicators of survival and confirmed that only deletions spanning the ABL/BCR breakpoint were associated with an adverse prognosis (P = .039).
  • [MeSH-major] Chromosome Deletion. Chromosomes, Human, Pair 9 / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Blast Crisis / genetics. Child. Disease Progression. Female. Fusion Proteins, bcr-abl / genetics. Fusion Proteins, bcr-abl / metabolism. Genes, abl / genetics. Humans. Karyotyping. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / therapy. Male. Middle Aged. Prognosis. Proto-Oncogene Proteins c-bcr / genetics. Survival Rate

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  • (PMID = 17456720.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / abl-bcr fusion protein, human; EC 2.7.10.2 / Fusion Proteins, bcr-abl; EC 2.7.11.1 / BCR protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr
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49. Ozcan O, Canbay A, Vural M, Diker E, Aydogdu S: Left main coronary artery aneurysm: report of three cases. Cardiovasc Revasc Med; 2007 Oct-Dec;8(4):278-80
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  • [Title] Left main coronary artery aneurysm: report of three cases.
  • Left main coronary artery (LMCA) aneurysm is a rare coronary abnormality defined as localized coronary artery dilatations>1.5 to 2 times the diameter of the adjacent segments.
  • The incidence of coronary artery aneurysm varies between 0.15% and 4.9%.
  • Here, we present three cases of LMCA aneuryms, of one which firstly diagnosed by multidetected computed tomography.
  • [MeSH-minor] Adult. Coronary Angiography. Diagnosis, Differential. Electrocardiography. Female. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18053950.001).
  • [ISSN] 1553-8389
  • [Journal-full-title] Cardiovascular revascularization medicine : including molecular interventions
  • [ISO-abbreviation] Cardiovasc Revasc Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Hurtado J, Pinar Bermúdez E, Redondo B, Lacunza Ruiz J, Gimeno Blanes JR, García de Lara J, Valdesuso Aguilar R, Teruel F, Valdés Chavarri M: Emergency percutaneous coronary intervention in unprotected left main coronary arteries. Predictors of mortality and impact of cardiogenic shock. Rev Esp Cardiol; 2009 Oct;62(10):1118-24
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  • [Title] Emergency percutaneous coronary intervention in unprotected left main coronary arteries. Predictors of mortality and impact of cardiogenic shock.
  • INTRODUCTION AND OBJECTIVES: Percutaneous coronary intervention (PCI) for unprotected left main coronary artery (LMCA) disease may be essential following acute myocardial infarction (AMI).
  • However, few data are available on the use of emergency PCI in unprotected LMCAs outside of clinical trials.
  • The objective of this study was to determine the frequency of in-hospital mortality, its predictors and its association with cardiogenic shock, and long-term outcomes in patients with unprotected LMCA disease who undergo emergency PCI because of AMI.
  • METHODS: The study included 71 consecutive patients who underwent emergency angioplasty of the LMCA and who were followed up clinically.
  • CONCLUSIONS: Emergency PCI is a viable therapeutic option for AMI due to unprotected LMCA disease.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / mortality. Coronary Artery Disease / therapy

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  • (PMID = 19793517.001).
  • [ISSN] 1579-2242
  • [Journal-full-title] Revista española de cardiología
  • [ISO-abbreviation] Rev Esp Cardiol
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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51. Bang V: PCI in unprotected LMCA disease: ethical dilemma or reality? Indian Heart J; 2008 May-Jun;60(3):177-8
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  • [Title] PCI in unprotected LMCA disease: ethical dilemma or reality?
  • [MeSH-minor] Coronary Artery Disease / physiopathology. Coronary Artery Disease / therapy. Humans. Stents

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  • [CommentOn] Indian Heart J. 2008 May-Jun;60(3):195-9 [19240306.001]
  • (PMID = 19240302.001).
  • [ISSN] 0019-4832
  • [Journal-full-title] Indian heart journal
  • [ISO-abbreviation] Indian Heart J
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] India
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52. Boztosun B, Aung SM, Olcay A, Kirma C: The longest documented left main coronary artery. Int J Cardiol; 2008 May 7;126(1):e17-8
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  • [Title] The longest documented left main coronary artery.
  • The left main coronary angiography (LMCA) ranges from 3 to 6 mm in diameter and may be up to 10 to 15 mm in length in humans.
  • We here report a case of the longest LMCA (38 mm) in a 60-year-old woman with subacute anterior myocardial infarction.
  • In coronary angiography and coronary computerized tomography LMCA was measured to be 38 mm long.
  • [MeSH-minor] Coronary Stenosis / diagnosis. Coronary Stenosis / pathology. Documentation / methods. Female. Humans. Middle Aged. Myocardial Infarction / diagnosis. Myocardial Infarction / pathology. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 17434626.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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53. Zeina AR, Rosenschein U, Barmeir E: Dimensions and anatomic variations of left main coronary artery in normal population: multidetector computed tomography assessment. Coron Artery Dis; 2007 Sep;18(6):477-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dimensions and anatomic variations of left main coronary artery in normal population: multidetector computed tomography assessment.
  • OBJECTIVES: The aim of our study was to determine the dimensions, morphology and anatomic variations of the left main coronary artery (LMCA) in normal participants, on multidetector computed tomography.
  • BACKGROUND: Accurate imaging of LMCA dimensions and configuration is crucial to avoid misdiagnosis of LMCA disease.
  • MATERIALS AND METHODS: Seventy morphologically normal LMCAs of 70 participants were carefully selected from among 600 consecutive coronary computed tomography angiography studies performed in our institute.
  • LMCA cross-sectional diameters and areas were obtained at three points of each vessel: ostium, midvessel and distal.
  • Influences of age, body weight, height and body surface area (BSA) on LMCA dimensions were evaluated.
  • RESULTS: Different dimensions in each measured point of the LMCA were detected.
  • Cross-sectional elliptic shape at ostium, mid-LMCA and distal LMCA was found in 66/70 (94%), 51/70 (73%) and 54/70 (77%) of the participants, respectively.
  • On the basis of the 3D presentation, four types of LMCA were identified: biconcave-shape appearance (type 1), tapering morphology (type 2), combined morphology (type 3) and funnel-shape appearance (type 4).
  • Fifty-two of the 70 participants had an LMCA orifice originating in the middle third of the aortic sinus, 15/70 in the posterior third and 3/70 in the anterior third.
  • In men, significant correlation was found between LMCA cross-sectional area and body weight, height and BSA.
  • CONCLUSION: LMCA is not a simple straight tube but usually has various anatomical configurations, variable dimensions and cross-sectional shapes.
  • Ostial angulation is a normal variant usually associated with the posterior position of the LMCA orifice of origin in the aortic sinus.
  • [MeSH-minor] Adult. Anatomy, Cross-Sectional. Coronary Artery Disease / pathology. Coronary Artery Disease / radiography. Female. Humans. Imaging, Three-Dimensional / methods. Male. Middle Aged

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  • (PMID = 17700220.001).
  • [ISSN] 0954-6928
  • [Journal-full-title] Coronary artery disease
  • [ISO-abbreviation] Coron. Artery Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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54. Takeshita H, Shimada Y, Kobayashi Y, Nishioka H, Ehara S, Kataoka T, Yoshiyama M: Impact of body mass index and Framingham risk score on coronary artery plaque. Osaka City Med J; 2008 Jun;54(1):31-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of body mass index and Framingham risk score on coronary artery plaque.
  • BACKGROUND: It is still unclear whether traditional risk factors for heart disease and body weight correlate with the progression of left main coronary artery (LMCA) atherosclerosis.
  • Thus, the aim of this study was to evaluate the cross-sectional relation between conventional risk score or metabolic disorder and non-stenotic LMCA atherosclerosis using intravascular ultrasound (IVUS).
  • METHODS: We analyzed procedural and demographic data from 217 consecutive patients undergoing intervention for a left anterior descending or left circumflex coronary artery lesion, including their cardiovascular risk (Framingham risk score) and degree of adiposity.
  • IVUS measurements for subclinical LMCA plaque were obtained in all patients and compared to their risk score (low, intermediate or high risk [< or =10%, 10-20%, and > or =20%, respectively]), with volumetric IVUS analyses being performed for the entire LMCA.
  • Linear regression analysis identified overweight/obesity (p=0.034) and high 10-year CAD risk (p=0.003) as independent predictors of increased LMCA plaque volume index.
  • CONCLUSIONS: Conventional coronary risk factors, as well as adiposity itself, related to the volume of coronary plaque at non-stenotic LMCA.
  • [MeSH-major] Body Mass Index. Coronary Artery Disease / epidemiology. Coronary Vessels / ultrasonography. Severity of Illness Index

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  • (PMID = 18819263.001).
  • [ISSN] 0030-6096
  • [Journal-full-title] Osaka city medical journal
  • [ISO-abbreviation] Osaka City Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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55. Gao RL, Xu B, Chen JL, Yang YJ, Qiao SB, Li JJ, Qin XW, Yao M, Liu HB, Wu YJ, Yuan JQ, Chen J: Immediate and long-term outcomes of drug-eluting stent implantation for unprotected left main coronary artery disease: comparison with bare-metal stent implantation. Am Heart J; 2008 Mar;155(3):553-61
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  • [Title] Immediate and long-term outcomes of drug-eluting stent implantation for unprotected left main coronary artery disease: comparison with bare-metal stent implantation.
  • BACKGROUND: The efficacy and safety of drug-eluting stent (DES) implantation for unprotected left main coronary artery (LMCA) disease remain to be established in different clinical settings.
  • METHODS: Elective DES implantation for unprotected LMCA stenosis was performed in 220 patients at the Fu Wai Hospital, China, from April 2003 to February 2006.
  • Data derived from the latter group were compared with those derived from 224 patients treated with bare-metal stents (BMSs) before March 2003 in a Chinese registry of unprotected LMCA stenting.
  • RESULTS: Compared with the historical BMS control group, the DES group had more multivessel disease and underwent more bifurcation stenting.
  • CONCLUSIONS: Based on this comparison with a historical control, DES implantation for unprotected LMCA appears safe in selected patients and might be more effective in preventing major adverse cardiac events compared with BMS implantation over a mean follow-up period of 15 months.
  • [MeSH-major] Blood Vessel Prosthesis Implantation / instrumentation. Coated Materials, Biocompatible. Coronary Disease / surgery. Metals. Myocardial Revascularization / methods. Stents

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  • (PMID = 18294496.001).
  • [ISSN] 1097-6744
  • [Journal-full-title] American heart journal
  • [ISO-abbreviation] Am. Heart J.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Coated Materials, Biocompatible; 0 / Immunosuppressive Agents; 0 / Metals; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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56. Bousquet M, Quelen C, De Mas V, Duchayne E, Roquefeuil B, Delsol G, Laurent G, Dastugue N, Brousset P: The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. Oncogene; 2005 Nov 3;24(48):7248-52
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  • [Title] The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.
  • Several tyrosine kinase genes are involved in chromosomal translocations in chronic myeloproliferative disorders, but there are still uncharacterized translocations in some cases.
  • We report two such cases corresponding to atypical chronic myeloid leukaemia with a t(8;9)(p22;p24) translocation.
  • By fluorescence in situ hybridisation (FISH) on the corresponding metaphases with a bacterial artificial chromosome probe encompassing the janus kinase 2 (JAK2) gene at 9p24, we observed a split for both patients, suggesting that this gene was rearranged.
  • [MeSH-major] Cell Cycle Proteins / genetics. Chromosomes, Human, Pair 8. Chromosomes, Human, Pair 9. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Oncogene Proteins, Fusion / genetics. Protein-Tyrosine Kinases / genetics. Proto-Oncogene Proteins / genetics. Translocation, Genetic

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  • [Copyright] Oncogene (2005) 24, 7248-7252. doi:10.1038/sj.onc.1208850; published online 8 August 2005.
  • [CommentIn] Oncogene. 2005 Nov 3;24(48):7125-6 [16007127.001]
  • (PMID = 16091753.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Autoantigens; 0 / Cell Cycle Proteins; 0 / Oncogene Proteins, Fusion; 0 / PCM1 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; 04079A1RDZ / Cytarabine; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2; X6Q56QN5QC / Hydroxyurea; ZRP63D75JW / Idarubicin
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57. Yilmaz-Cankaya B, Kantarci M, Yalcin A, Durur-Karakaya A, Yuce I: Absence of the Left Main Coronary Artery: MDCT Coronary Angiographic Imaging. Eurasian J Med; 2009 Apr;41(1):56-8
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  • [Title] Absence of the Left Main Coronary Artery: MDCT Coronary Angiographic Imaging.
  • Absent left main coronary artery (LMCA) is a rare congenital cardiac malformation.
  • We present a case report of a 65-year-old woman with anomalous origin of the left anterior descending (LAD) and circumflex (LCx) artery separated from the left sinus of Valsalva that was diagnosed by multi-detector row computed tomography (MDCT) coronary angiography.
  • Our case indicates that MDCT plays an important role in the diagnosis of some rare coronary anomalies.

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  • (PMID = 25610065.001).
  • [ISSN] 1308-8734
  • [Journal-full-title] The Eurasian journal of medicine
  • [ISO-abbreviation] Eurasian J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC4261659
  • [Keywords] NOTNLM ; Absent Left Main Coronary Artery / Coronary variation / MDCT
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58. Lopez L, Mercer-Rosa L, Zahn EM, Altman NR, Dubois R, Burke RP: The "hinge-twist" technique for anomalous origin of the left coronary artery. Ann Thorac Surg; 2006 Aug;82(2):e19-21
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  • [Title] The "hinge-twist" technique for anomalous origin of the left coronary artery.
  • A murmur was heard in an asymptomatic boy (age 4), and transthoracic echocardiography revealed anomalous origin of the left main coronary artery (LMCA) from the right sinus of Valsalva (age 6).
  • Confirmed by catheterization and computed tomographic angiography (age 10), the LMCA followed a short interarterial course between the aorta and main pulmonary artery before supplying the anterior descending and circumflex coronary arteries.

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  • (PMID = 16863730.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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59. Sari I, Acar Z, Nurkalem Z, Uslu N, Davutoglu V, Ates M, Ozer O, Eren M, Aksoy M: Preoperative clinical status but not waiting time predicts in-hospital outcomes of surgery in patients with left main coronary artery stenosis. Tohoku J Exp Med; 2007 Oct;213(2):173-80
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  • [Title] Preoperative clinical status but not waiting time predicts in-hospital outcomes of surgery in patients with left main coronary artery stenosis.
  • Contoversy exists about the optimal operation time of the patients with left main coronary artery (LMCA) stenosis.
  • We therefore, aimed to investigate the effect of waiting time on in-hospital morbidity and mortality in patients with LMCA stenosis and identify the risk factors associated with adverse cardiovascular events before and during surgery.
  • One hundred seventy six patients with LMCA stenosis were divided into two groups according to the time period between coronary angiography and coronary artery bypass surgery (group 1: <or= 7 days, 94 patients; and group 2: > 7 days, 82 patients).
  • When we analyzed the differences between the patients with and without MACE, the patients who experienced MACE were older (p = 0.001), and had higher degree of LMCA stenosis (p = 0.01), higher degree of right coronary artery stenosis (p = 0.02), higher blood urea level (p = 0.003), and higher incidence of unstable angina or myocardial infarction within 2 weeks (p = 0.001).
  • Independent risk factors for MACE were unstable angina or myocardial infarction within 2 weeks, age more than 70 years and stenosis more than 75% in the LMCA.
  • These results suggest that preoperative clinical status but not waiting time predicts in-hospital surgical outcomes in LMCA stenosis.
  • [MeSH-minor] Aged. Coronary Angiography. Coronary Artery Bypass / statistics & numerical data. Female. Humans. Logistic Models. Male. Middle Aged. Multivariate Analysis. Predictive Value of Tests. Preoperative Care. Time Factors. Treatment Outcome

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  • (PMID = 17917411.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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60. Tanigawa J, Sutaria N, Goktekin O, Di Mario C: Treatment of unprotected left main coronary artery stenosis in the drug-eluting stent era. J Interv Cardiol; 2005 Dec;18(6):455-65
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  • [Title] Treatment of unprotected left main coronary artery stenosis in the drug-eluting stent era.
  • Coronary angiography is often inadequate for estimating the severity of ambiguous left main coronary artery (LMCA) stenoses.
  • For patients requiring LMCA revascularization, coronary artery bypass graft (CABG) surgery has been gold standard for decades.
  • LMCA stenosis remains one of the few serious challenges for the interventional cardiologists and, in the bare metal stent era, the long-term results were not sufficient to replace CABG surgery, mainly because of the high restenosis rate.
  • Drug-eluting stents (DES) have dramatically reduced the restenosis rate and early results in small series (approximately 300 patients in total) treated with DES in LMCA have been encouraging, especially for lesions at the ostium and in the left main shaft.
  • Before changes are made in the guidelines for treatment, we must wait for a refinement in the technique and stent design used for bifurcational left main lesion and the results of randomized, specific multicenter studies (SYNTAX trial).
  • It is likely that, for selected patients, LMCA stenosis will be regarded as an indication for PCI.
  • [MeSH-minor] Angioplasty, Balloon, Coronary. Atherectomy, Coronary. Coronary Artery Bypass. Coronary Restenosis / prevention & control. Humans. Immunosuppressive Agents / administration & dosage. Sirolimus / administration & dosage

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  • [Copyright] (J Interven Cardiol 2005;18:455-465).
  • (PMID = 16336426.001).
  • [ISSN] 0896-4327
  • [Journal-full-title] Journal of interventional cardiology
  • [ISO-abbreviation] J Interv Cardiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
  • [Number-of-references] 60
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61. Edris A, Patel PM, Kern MJ: Early recognition of catheter-induced left main coronary artery vasospasm: implications for revascularization. Catheter Cardiovasc Interv; 2010 Aug 1;76(2):304-7
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  • [Title] Early recognition of catheter-induced left main coronary artery vasospasm: implications for revascularization.
  • Catheter-induced left main coronary artery (LMCA) vasospasm is a rare complication of coronary angiography that confounds the decision for coronary artery bypass graft (CABG) surgery.
  • We report two cases of catheter-induced LMCA vasospasm.
  • The first case was a 68-year-old woman who presented 6 years after CABG for presumed severe LMCA atherosclerotic disease.
  • Coronary angiography demonstrated totally occluded CABGs and normal native coronary arteries, including a normal LMCA.
  • The second case was a 56-year-old man with severe LMCA stenosis, who was scheduled for unprotected LM percutaneous coronary intervention (PCI).
  • These cases emphasize the need for meticulous technique and a high index of suspicion of LMCA vasospasm.
  • Intravascular ultrasound (IVUS) at the time of angiography may help to identify minimal atherosclerotic disease suggesting vasospasm.
  • [MeSH-major] Coronary Angiography / adverse effects. Coronary Artery Bypass. Coronary Stenosis / radiography. Coronary Vasospasm / etiology. Diagnostic Errors / prevention & control. Unnecessary Procedures
  • [MeSH-minor] Aged. Early Diagnosis. Electrocardiography. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Vasodilator Agents / administration & dosage

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20665882.001).
  • [ISSN] 1522-726X
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents
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62. Murasato Y, Suzuka H, Suzuki Y: Incomplete stent apposition in a left main bifurcated lesion after kissing stent implantation. J Invasive Cardiol; 2006 Nov;18(11):E279-84
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  • [Title] Incomplete stent apposition in a left main bifurcated lesion after kissing stent implantation.
  • We present the case of a 75-year-old female who developed restenosis after the deployment of kissing sirolimus-eluting stents at the left main coronary artery (LMCA) bifurcation.
  • Restenosis occurred at the left circumflex (LCx) artery ostium, where a stent deployed from the LMCA to the LCx arteries overlapped another stent deployed from the LMCA to the left anterior descending (LAD) artery.
  • We investigated the stent expansion and deformation after kissing stent implantation using a phantom three-dimensional model depicting a LMCA bifurcation.
  • Stent overlap was detected at the distal LMCA whether the LAD stent was positioned over the left circumflex (LCx) stent or vice versa.
  • Thus, we found that kissing stent implantation using different-sized stents produced compression of the LCx stent at the distal LMCA.
  • Incomplete stent apposition caused by stent overlap and stent deformation is thought to be the main mechanism for restenosis after kissing stent implantation procedures.

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  • (PMID = 17090830.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] W36ZG6FT64 / Sirolimus
  • [Number-of-references] 17
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63. Guerrero RR, Wilkinson JL, Brizard CP: Reconstruction of left main coronary artery with subclavian artery free graft in an infant. Eur J Cardiothorac Surg; 2005 May;27(5):927-9
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  • [Title] Reconstruction of left main coronary artery with subclavian artery free graft in an infant.
  • We report the case of a 3-month-old infant with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) with absent left main coronary artery (LMCA).
  • She underwent repair by reimplantation technique with the construction of a short LMCA using two opposite flaps.
  • Occlusion of the reconstructed LMCA was found by angiogram.
  • At reoperation the right subclavian artery was used as a free interposition graft to reconstruct the LMCA.
  • At 8 months she was asymptomatic and LMCA patency was demonstrated by angiogram.
  • [MeSH-major] Coronary Vessel Anomalies / surgery. Coronary Vessels. Subclavian Artery / transplantation

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  • (PMID = 15848342.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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64. Han YL, Wang SL, Jin QM, Liu HW, Ma YY, Wang ZL, Wang DM, Luan B, Wang G: Efficacy of stenting for unprotected left main coronary artery disease in 297 patients. Chin Med J (Engl); 2006 Apr 5;119(7):544-50
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  • [Title] Efficacy of stenting for unprotected left main coronary artery disease in 297 patients.
  • BACKGROUND: Angioplasty in the unprotected left main coronary artery (LMCA) has been controversial.
  • This study aims to evaluate the safety and clinical effectiveness of stenting, including bare metal stent and drug eluting stent (DES), for treatment of unprotected LMCA disease.
  • METHODS: Between September 1997 and December 2005, a total of 297 consecutive patients underwent percutanous coronary intervention (PCI) on LMCA lesions in our hospital.
  • Stents failed to be implanted after balloon predilation in two patients, who received coronary artery bypass graft (CABG) successfully.
  • Bifurcation techniques for distal LMCA executed in 206 patients (69.4%, 206/297), included crossover stenting in 156 (75.7%), T stenting in 4 (1.9%), provisional T stenting in 28 (13.6%), kissing stenting in 5 (2.4%) and stent crushing in 13 (6.3%) patients.
  • Besides, 2 (0.7%) developed subacute thrombosis (SAT) and 16 (5.4%) performed target lesion revascularization (TLR).
  • CONCLUSIONS: As new PCI strategies and intervention devices such as DES are developed, coronary stenting, which might have brought better in-hospital and long-term outcomes than CABG, are proved to be technically successful and can be safely applied for the treatment of LMCA lesions in the experienced center for coronary intervention.
  • [MeSH-major] Coronary Disease / therapy. Stents

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  • (PMID = 16620694.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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65. Liu XB, Qian JY, Ge L, Zhang F, Fan B, Wang QB, Lu Y, Ge JB: [Morphological characteristics of ostial and non-ostial left main coronary artery lesion without heavy calcification determined by intravascular ultrasound imaging]. Zhonghua Xin Xue Guan Bing Za Zhi; 2008 Nov;36(11):975-9
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  • [Title] [Morphological characteristics of ostial and non-ostial left main coronary artery lesion without heavy calcification determined by intravascular ultrasound imaging].
  • OBJECTIVE: We aimed to assess and compare the morphological characteristics of ostial and non-ostial left main coronary artery (LMCA) lesion without heavy calcification using intravascular ultrasound (IVUS) imaging.
  • 2007, 153 patients with confirmed or suspected coronary artery narrowing in coronary angiography with satisfactory IVUS images and non-heavy calcification were included in the study (ostial lesions, n = 47; non-ostial lesion, n = 106).
  • Negative remodeling was defined as RI < 0.95.
  • RESULTS: LMCA mean reference lumen and vessel diameter was 4.1 +/- 0.8 mm and 5.3 +/- 0.8 mm respectively.
  • Compared to non-ostial lesions, ostial lesion had significant smaller plaque area [(10.8 +/- 4.5) mm(2) vs. (13.3 +/- 5.4) mm(2), P = 0.007], less plaque burden (54.8% +/- 15.9% vs. 61.9% +/- 14.5%, P = 0.020), smaller RI (0.9 +/- 0.2 vs. 1.0 +/- 0.2, P = 0.000) and higher incidence of negative remodeling (74.5% vs. 34.9%, P = 0.000).
  • Multivariant Logistic regression analysis showed that the site of lesion (ostial or non-ostial lesion, OR = 4.9, P = 0.004), plaque area (OR = 1.2, P = 0.01) and plaque burden (OR = 0.003, P = 0.000) were the independent predictors of LMCA remodeling.
  • CONCLUSION: Negative remodeling might be responsible for the development of LMCA ostial narrowing.
  • [MeSH-major] Calcinosis / ultrasonography. Coronary Artery Disease / ultrasonography. Ultrasonography, Interventional / methods

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  • (PMID = 19102908.001).
  • [ISSN] 0253-3758
  • [Journal-full-title] Zhonghua xin xue guan bing za zhi
  • [ISO-abbreviation] Zhonghua Xin Xue Guan Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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66. Prieto-Solís JA, Benito N, Martín-Durán R: [Electrocardiographic diagnosis of left main coronary artery obstruction using ST-segment and QRS-complex vector analysis]. Rev Esp Cardiol; 2008 Feb;61(2):137-45
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  • [Title] [Electrocardiographic diagnosis of left main coronary artery obstruction using ST-segment and QRS-complex vector analysis].
  • [Transliterated title] Diagnóstico electrocardiográfico de la obstrucción del tronco coronario izquierdo mediante el análisis vectorial del segmento ST y el complejo QRS.
  • INTRODUCTION AND OBJECTIVES: It is vital that obstruction of the left main coronary artery (LMCA) is diagnosed early.
  • We investigated the value of ST-segment and QRS-complex vector analysis in identifying LMCA obstruction in acute coronary syndrome.
  • METHODS: The study involved 57 consecutive patients with electrocardiographic features suggestive of LMCA obstruction.
  • RESULTS: Coronary angiography showed that the obstructed vessel was the LMCA in 20 patients, the left circumflex artery in 19, the right coronary artery in 10, and the left anterior descending artery in three.
  • Five patients had three-vessel disease.
  • An ST vector that was directed between -90 degrees and 180 degrees in the frontal plane was observed in 100% of patients with an LMCA obstruction (P< .001).
  • An ST vector directed anteriorly or parallel to the horizontal plane was present in 95% of patients (19/20) with an LMCA obstruction (P< .001; specificity 92%).
  • A QRS vector with a left shift é-30 degrees was observed in 75% (15/20) with LMCA disease (P< .001; specificity 95%).
  • An ST vector directed between -90 degrees and 180 degrees and anteriorly had a sensitivity of 95% and specificity of 100% for LMCA obstruction.
  • An ST vector directed between -90 degrees and 180 degrees combined with a left QRS vector shift > or =-30 degrees had a sensitivity of 75% and a specificity of 100% for LMCA obstruction.
  • A simple algorithm combining these observation was able to predict LMCA obstruction in 100% of patients.
  • CONCLUSIONS: In acute coronary syndrome, ST-segment and QRS-complex vector analysis can predict the presence of LMCA obstruction.
  • [MeSH-major] Coronary Stenosis / diagnosis. Electrocardiography

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  • [CommentIn] Rev Esp Cardiol. 2009 Jan;62(1):105-6; author reply 106-8 [19150026.001]
  • (PMID = 18364182.001).
  • [ISSN] 1579-2242
  • [Journal-full-title] Revista española de cardiología
  • [ISO-abbreviation] Rev Esp Cardiol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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67. Eaton KP, Szaflarski JP, Altaye M, Ball AL, Kissela BM, Banks C, Holland SK: Reliability of fMRI for studies of language in post-stroke aphasia subjects. Neuroimage; 2008 Jun;41(2):311-22
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  • Here we report inter-scan variability measures for fMRI activation patterns associated with verb generation (VG) and semantic decision/tone decision (SDTD) tasks in 4 healthy controls and 4 aphasic left middle cerebral artery (LMCA) stroke subjects.
  • These quantitative measures of inter-scan variability support the proposed use of these fMRI paradigms for longitudinal mapping of neural reorganization of language processing following left hemispheric insult.

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  • (PMID = 18411061.001).
  • [ISSN] 1053-8119
  • [Journal-full-title] NeuroImage
  • [ISO-abbreviation] Neuroimage
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K23 NS052468; United States / NINDS NIH HHS / NS / K23 NS052468-02; United States / NIBIB NIH HHS / EB / T32 EB001656; United States / NIBIB NIH HHS / EB / T32-EB01656
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS54162; NLM/ PMC2474692
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68. Markert E, Siebolts U, Odenthal M, Kreuzer KA, Wickenhauser C: High diagnostic value of morphologic examination and molecular analysis of bone marrow biopsies in a case of BCR-ABL+ CML with clusters of blasts. Int J Hematol; 2009 Apr;89(3):294-7
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  • [Title] High diagnostic value of morphologic examination and molecular analysis of bone marrow biopsies in a case of BCR-ABL+ CML with clusters of blasts.
  • We report a clinical case of chronic myelogenous leukaemia (CML) with regional B-lymphoblastic transformation.
  • Peripheral leukocytosis of 160 x 10(9)/L, splenomegaly and fatigue suggested CML.
  • In peripheral blood and bone marrow smears, white blood cells in all maturation stages and only few blasts were seen and therefore the diagnosis of chronic phase CML was proposed.
  • Cytogenetics performed on peripheral blood cells revealed the characteristic t(9;22)(q34;q11) translocation as solitary abnormality.
  • BCR-ABL FISH analysis demonstrated 31% atypical split signals in the B-lymphoid blasts and in the maturing myeloid cells, furthermore, BCR-ABL fusion transcripts were seen in the RT-PCR assay.
  • BCR-ABL FISH analysis still presented 21% atypical split signals but levels of BCR-ABL transcripts had significantly fallen indicating a rather favourable prognosis.
  • However, 3 months after diagnosis the patient relapsed and developed an immunodeficiency with soor esophagitis and aspergillus pneumonia.
  • This report demonstrates the high diagnostic value of bone marrow biopsy in the evaluation of CML.
  • [MeSH-major] Bone Marrow / metabolism. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism

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  • [Cites] N Engl J Med. 2003 Oct 9;349(15):1423-32 [14534335.001]
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  • (PMID = 19229589.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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69. Aydinlar A, Ciçek D, Sentürk T, Gemici K, Serdar OA, Kazazoglu AR, Kumbay E, Cordan J: Primary congenital anomalies of the coronary arteries: a coronary arteriographic study in Western Turkey. Int Heart J; 2005 Jan;46(1):97-103
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  • [Title] Primary congenital anomalies of the coronary arteries: a coronary arteriographic study in Western Turkey.
  • Coronary artery anomalies are found in 0.6% to 1.5% of coronary angiograms.
  • Ninty-five (95%) of the patients had anomalies of origin and distribution while five (5%) had coronary artery fistulae.
  • The left main coronary artery (LMCA) was the most common anomalous vessel involved (forty-eight (48%) of the patients).
  • An LMCA distribution anomaly was observed in these 48 patients.
  • An anomalous right coronary artery (RCA) was the second most common anomaly, seen in twenty-two (22%) of the patients.
  • An anomalous circumflex artery (Cx) was the third most common anomaly, seen in seventeen.
  • Five patients had a coronary artery fistulae.

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  • (PMID = 15858941.001).
  • [ISSN] 1349-2365
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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70. Matsumoto N, Sato Y, Kunimasa T, Yoda S, Yokoyama S, Takayama T, Komatsu S, Achenbach S, Saito S, Hirayama A: MDCT detection of anomalous origins of the left main coronary artery: report of 2 cases. Int J Cardiol; 2008 Nov 28;130(3):485-7
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  • [Title] MDCT detection of anomalous origins of the left main coronary artery: report of 2 cases.
  • The left main coronary artery (LMCA) arising either from the right sinus of Valsalva, separately from the right coronary artery (RCA), or from the RCA as a single coronary artery is an extremely rare coronary artery anomaly.
  • We report 2 cases of anomalous origins of the LMCA detected by multidetector-row computed tomography.
  • [MeSH-major] Coronary Angiography. Coronary Artery Disease / radiography. Coronary Vessel Anomalies / radiography. Tomography, X-Ray Computed

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  • (PMID = 17707930.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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71. Burmeister T, Reinhardt R: A multiplex PCR for improved detection of typical and atypical BCR-ABL fusion transcripts. Leuk Res; 2008 Apr;32(4):579-85
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  • [Title] A multiplex PCR for improved detection of typical and atypical BCR-ABL fusion transcripts.
  • RT-PCR is the method of choice for detecting BCR-ABL in CML and ALL.
  • The three predominant mRNA transcripts found are e1a2 (in ALL), e13a2, and e14a2 (in CML and ALL).
  • However, a number of "atypical"BCR-ABL transcripts (e1a3, e13a3, e14a3, e19a2, e6a2, e8a2, etc.) resulting from chromosomal breakpoints outside ABL intron 1 or BCR intron 1, 13 or 14, respectively, have been reported.
  • These atypical transcripts may escape detection when using methods that are optimized to detect just the typical ones.
  • We present here a novel, fast, and reliable multiplex PCR for improved detection of typical and atypical BCR-ABL transcripts.
  • [MeSH-major] Fusion Proteins, bcr-abl / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. RNA, Messenger / genetics. RNA, Neoplasm / genetics

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  • (PMID = 17928051.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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72. Lin Y, Bruyère H, Horsman DE, Pantzar T, Barnett MJ, Hogge DE, Nevill TJ, Nantel SH, Sutherland HJ, Toze CL, Shepherd JD, Lavoie JC, Song KW, Smith CA, Forrest DL: Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors. Cancer Genet Cytogenet; 2006 Oct 1;170(1):16-23
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  • [Title] Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors.
  • There are increasing reports of Philadelphia-negative (Ph-negative) clonal hematopoiesis developing among patients with chronic myeloid leukemia (CML) treated with imatinib mesylate (IM).
  • To establish the incidence and significance of these chromosomal abnormalities, we analyzed data on 141 consecutive patients with CML treated with IM at the British Columbia Cancer Agency and Vancouver General Hospital from 1999 to 2004.
  • The cumulative incidence of developing a Ph-negative clone three years from the start of IM was 8.7% at a median of 13.3 months.
  • The Ph-negative clonal abnormalities included monosomy 7 and/or trisomy 8 (seven patients), monosomy for chromosomes X and 22 (one patient), and a (12;16) translocation (one patient).
  • Two of the patients presented with the same chromosomal abnormality in both Ph-negative and Ph-positive cells.
  • None of the Ph-negative clonal abnormalities was associated with myelodysplasia.
  • In a multivariate analysis, an interval from diagnosis to initiation of IM of 1 year or less was associated with an increased risk of developing a Ph-negative clone (relative risk = 20.2; P = 0.025).
  • There was no difference, however, in event-free survival between patients who did and did not develop Ph-negative clones.
  • Therefore, while the development of Ph-negative clonal hematopoiesis in patients with CML treated with IM is uncommon, it appears to be more frequent than that previously seen with IFN, but it does not seem to confer a worse prognosis.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Hematopoiesis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Piperazines / therapeutic use. Pyrimidines / therapeutic use


73. Piña Y, Exaire JE, Sandoval J: Left main coronary artery extrinsic compression syndrome: a combined intravascular ultrasound and pressure wire. J Invasive Cardiol; 2006 Mar;18(3):E102-4
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  • [Title] Left main coronary artery extrinsic compression syndrome: a combined intravascular ultrasound and pressure wire.
  • The compression of the left main coronary artery (LMCA) secondary to pulmonary artery trunk dilatation is a relatively new entity that has been associated with severe pulmonary hypertension.
  • We report a case of a woman with severe pulmonary arterial hypertension due to an atrial septal defect with extrinsic compression of the LMCA and a physiopathologic approach to guide its treatment.

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  • (PMID = 16495602.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Qin YZ, Jiang B, Jiang Q, Zhang Y, Jiang H, Li JL, Zhu HH, Li LD, Liu YR, Chen SS, Huang XJ: Imatinib mesylate resistance in a chronic myeloid leukemia patient with a novel e8a2 BCR-ABL transcript variant. Acta Haematol; 2008;120(3):146-9
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  • [Title] Imatinib mesylate resistance in a chronic myeloid leukemia patient with a novel e8a2 BCR-ABL transcript variant.
  • BACKGROUND: The vast majority of chronic myeloid leukemia (CML) patients express the BCR-ABL transcript with the b2a2 (e13a2) and/or b3a2 (e14a2) junctions.
  • However, some rare cases have atypical breakpoints.
  • METHODS AND RESULTS: We identified a CML patient with a unique e8a2 BCR-ABL transcript variant.
  • It contained the first 114 nucleotides of BCR exon 8, with an insertion of 16 nucleotides from the 3' end of ABL intron 1a, followed by ABL exon 2.
  • Due to her uncontrolled thrombocytosis after 3 years of interferon-alpha treatment, the patient received imatinib at a dosage of 400 mg/day.
  • That is, she failed to achieve major cytogenetic response and there was no significant decrease in her BCR-ABL transcript levels.
  • CONCLUSION: ABL point mutation is also a mechanism of imatinib resistance for CML patients with the BCR-ABL transcript variant.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Drug Resistance, Neoplasm / genetics. Fusion Proteins, bcr-abl / genetics. Gene Expression Regulation, Leukemic / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Piperazines / administration & dosage. Point Mutation. Pyrimidines / administration & dosage

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19039205.001).
  • [ISSN] 1421-9662
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Immunologic Factors; 0 / Interferon-alpha; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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75. Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen KT, Flores NJ, Estey E, Gattermann N, Armstrong S, Look AT, Griffin JD, Bernard OA, Heinrich MC, Gilliland DG, Druker B, Deininger MW: The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood; 2005 Nov 15;106(10):3377-9
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  • [Title] The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
  • Recently, we and others identified a single recurrent somatic activating mutation (JAK2V617F) in the Janus kinase 2 (JAK2) tyrosine kinase in the myeloproliferative disorders (MPDs) polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
  • We used direct sequence analysis to determine if the JAK2V617F mutation was present in acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML)/atypical chronic myelogenous leukemia (aCML), myelodysplastic syndrome (MDS), B-lineage acute lymphoblastic leukemia (ALL), T-cell ALL, and chronic lymphocytic leukemia (CLL).
  • JAK2V617F mutations were identified in 9 (7.8%) of 116 CMML/a CML samples, and in 2 (4.2%) of 48 MDS samples.
  • We did not identify the JAK2V617F disease allele in B-lineage ALL (n = 83), T-cell ALL (n = 93), or CLL (n = 45).
  • These data indicate that the JAK2V617F allele is present in acute and chronic myeloid malignancies but not in lymphoid malignancies.


76. Paç FA, Cağdaş DN, Ulaş M, Ozatik MA, Paç M: Left main coronary artery and aortic root compression associated with atrial septal defect and pulmonary hypertension. Int J Cardiol; 2007 May 31;118(2):e41-3
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  • [Title] Left main coronary artery and aortic root compression associated with atrial septal defect and pulmonary hypertension.
  • The extrinsic compression of left main coronary artery (LMCA) by dilated pulmonary artery is rarely reported.
  • Various congenital and acquired diseases were shown to cause extrinsic LMCA compression.
  • Here we present a child with aortic root and LMCA compression due to dilated pulmonary trunk and causing angina like chest pain.
  • This case report will be a guide for the evaluation and surgical treatment of the patients with pulmonary hypertension and LMCA compression.
  • [MeSH-minor] Chest Pain / etiology. Child. Dyspnea / etiology. Female. Humans. Pulmonary Artery / surgery

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  • (PMID = 17395318.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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77. Hackanson B, Rückert A, Lübbert M: Hyperleukocytotic secondary acute myeloid leukemia (AML) with sole monosomy 7 as sequela of Philadelphia-chromosome positive chronic myeloid leukemia (CML). Eur J Haematol; 2009 Dec 1;83(6):611-2
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  • [Title] Hyperleukocytotic secondary acute myeloid leukemia (AML) with sole monosomy 7 as sequela of Philadelphia-chromosome positive chronic myeloid leukemia (CML).
  • [MeSH-major] Chromosomes, Human, Pair 7. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Acute / genetics. Leukocytosis / etiology. Monosomy
  • [MeSH-minor] Aged. Anemia, Refractory, with Excess of Blasts / etiology. Anemia, Refractory, with Excess of Blasts / genetics. Anemia, Refractory, with Excess of Blasts / pathology. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Benzamides. Chromosome Deletion. Cytarabine / administration & dosage. Disease Progression. Fatal Outcome. Humans. Imatinib Mesylate. Interferon-alpha / administration & dosage. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / pathology. Male. Philadelphia Chromosome. Piperazines / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Pyrimidines / therapeutic use. Selection, Genetic


78. Vecchio S, Chechi T, Vittori G, Biondi Zoccai GG, Lilli A, Spaziani G, Giuliani G, Falchetti E, Margheri M: Outlook of drug-eluting stent implantation for unprotected left main disease: insights on long-term clinical predictors. J Invasive Cardiol; 2007 Sep;19(9):381-7
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  • [Title] Outlook of drug-eluting stent implantation for unprotected left main disease: insights on long-term clinical predictors.
  • BACKGROUND: Percutaneous coronary intervention (PCI) has been increasingly employed to treat unprotected left main coronary artery (LMCA) stenosis, with variable success.
  • This strategy has been applied to patients undergoing drug-eluting stent (DES) implantation for unprotected LMCA stenosis.
  • METHODS: From April 2003 to June 2006, 114 consecutive patients with de novo unprotected LMCA stenosis underwent PCI with DES, and were followed over a mean period of 17.1 +/- 9.1 months.
  • RESULTS: LMCA stenting was successfully performed in all patients.
  • In-hospital mortality was 3.5%, with no in-hospital non-fatal MI or emergency coronary artery bypass grafts.
  • Acute coronary syndromes, as clinical presentation, and non-ostial LMCA disease were also significantly more common within non-surviving patients (100% vs. 67%; p < 0.05, and 92.3% vs. 66.3%; p = 0.05, respectively).
  • CONCLUSIONS: Stenting of unprotected LMCA appears to be associated with a favorable mid-term outlook, especially in selected patients.
  • [MeSH-major] Angioplasty, Balloon, Coronary / mortality. Coronary Artery Disease / therapy. Coronary Restenosis / prevention & control. Immunosuppressive Agents / administration & dosage. Sirolimus / administration & dosage. Stents

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  • [CommentIn] J Invasive Cardiol. 2007 Sep;19(9):388-9 [17827508.001]
  • (PMID = 17827507.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Immunosuppressive Agents; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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79. Popovici C, Cailleres S, David M, Lafage-Pochitaloff M, Sainty D, Mozziconacci MJ: E6a2 BCR-ABL fusion with BCR exon 5-deleted transcript in a Philadelphia positive CML responsive to Imatinib. Leuk Lymphoma; 2005 Sep;46(9):1375-7
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  • [Title] E6a2 BCR-ABL fusion with BCR exon 5-deleted transcript in a Philadelphia positive CML responsive to Imatinib.
  • Chronic myeloid leukemia (CML) is characterized in 90% of patients by the presence of the reciprocal translocation t(9;22)(q34;q11) leading to the fusion of the BCR and ABL genes.
  • Most patients with Philadelphia chromosome positive CML express either the e13a2 (b2a2) or e14a2 (b3a2) MBCR-ABL mRNA.
  • Some variant cases have been reported expressing the fusion e1a2 (mBCR-ABL) or e19a2 (microBCR-ABL).
  • Very rare atypical transcripts such as e13a3, e14a3 or e6a2 have been described.
  • We report here a sixth case of a Ph positive patient with an e6a2 BCR-ABL fusion transcript and describe for the first time a chimeric molecule alternatively spliced for exon 5 of the BCR gene.
  • [MeSH-major] Fusion Proteins, bcr-abl / metabolism. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 16109618.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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80. Mahajan N, Hollander G, Thekkoott D, Temple B, Malik B, Abrol S, Yens D, Shani J, Lichstein E: Prediction of left main coronary artery obstruction by 12-lead electrocardiography: ST segment deviation in lead V6 greater than or equal to ST segment deviation in lead V1. Ann Noninvasive Electrocardiol; 2006 Apr;11(2):102-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prediction of left main coronary artery obstruction by 12-lead electrocardiography: ST segment deviation in lead V6 greater than or equal to ST segment deviation in lead V1.
  • BACKGROUND: Acute coronary syndrome (ACS) resulting from culprit lesion in left main coronary artery (LMCA) can cause rapid hemodynamic deterioration.
  • ST segment elevation in aVR greater than or equal to V(1) (aVR-V(1)>or= 0) has been suggested as a sensitive predictor of LMCA disease.
  • As a result of balanced forces, we hypothesized that ST deviation in V(6) greater than or equal to ST deviation in V(1) (V(6)-V(1)>or= 0) might be a good determinant of LMCA disease.
  • METHODS: We compared admission 12-lead ECGs of ACS resulting from culprit LMCA lesion (n = 75, group I) with ACS resulting from culprit left anterior descending lesion (n = 81, group II).
  • The reliabilities of V(6)-V(1)>or= 0, V(6)/V(1)>or= 1, aVR-V(1)>or= 0, and aVR/V(1)>or= 1 in predicting LMCA disease were determined.
  • CONCLUSION: This is the largest series of ECG analysis on ACS resulting from culprit LMCA lesion.
  • V(6)-V(1)>or= 0 and V(6)/V(1)>or= 1 were more sensitive in predicting LMCA as culprit vessel in comparison to previously reported greater ST segment elevation in aVR than V(1).
  • [MeSH-major] Coronary Stenosis / diagnosis. Electrocardiography / methods

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  • (PMID = 16630083.001).
  • [ISSN] 1082-720X
  • [Journal-full-title] Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
  • [ISO-abbreviation] Ann Noninvasive Electrocardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Ng MK, Yeung AC: Left main coronary artery disease: is CABG still the gold standard? Rev Cardiovasc Med; 2005;6(4):187-93
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  • [Title] Left main coronary artery disease: is CABG still the gold standard?
  • Severe stenosis of the left main coronary artery (LMCA) is a coronary artery-disease manifestation of critical prognostic importance.
  • As a consequence of the survival advantage conferred by coronary artery bypass grafting (CABG) over medical therapy, lesions in the LMCA have been considered a standard indication for CABG for nearly 3 decades.
  • Initial attempts to treat LMCA disease percutaneously by balloon angioplasty resulted in poor clinical outcomes, leading many to regard significant LMCA disease as a contraindication for percutaneous coronary intervention (PCI).
  • However, the development and refinement of coronary stenting over the last 15 years, followed by the recent introduction of drug-eluting stents, has fueled renewed interest in percutaneous treatment of LMCA disease.
  • Outcomes of recent studies using sirolimus- and/or paclitaxel-eluting stents for treatment of LMCA disease have yielded rates of in-hospital and 1-year mortality that compare favorably with those of surgery.
  • This article will review the natural history of LMCA disease, the outcomes of CABG for LMCA disease, and the history and recent developments regarding PCI for LMCA disease.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Bypass. Coronary Artery Disease / therapy. Coronary Stenosis / therapy. Stents


82. Lai YY, Feng L, Wang Z, He Q, Dang H, Shi Y, Lv S, Qin YZ, Huang XJ: [Laboratory study on a rare case of chronic myeloid leukemia with ins(22;9)t(9;13) and Ph-negative]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2010 Apr;18(2):355-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laboratory study on a rare case of chronic myeloid leukemia with ins(22;9)t(9;13) and Ph-negative].
  • The study aimed to examine a rare case of Philadelphia (Ph)-negative chronic myeloid leukemia (CML) with t(9;13).
  • Chromosome samples were prepared after culture of bone marrow cells for 24 hours, the karyotypes were analyzed by G banding technique.
  • Chromosome painting analysis was performed by using whole chromosome paints for chromosomes 9 and 22.
  • Fluorescence in situ hybridization (FISH) was done with dual color dual fusion LSI bcr/abl probe.
  • Bcr/abl transcripts were detected by real time fluorescence quantitative polymerase chain reaction (RQ-PCR).
  • FISH assay using LSI bcr/abl DNA probe showed a red abl signal inserted into der(22) and a fusion signal of bcr/abl rearrangement was discovered.
  • RQ-PCR detected high copies of bcr/abl transcripts.
  • In conclusion, insertion of bcr/abl rearrangement was a rare variant t(9;22) and could be well detected by molecular techniques, however, regular cytogenetic banding technique and whole chromosome paintings may probably lead a misdiagnosis to such cases.


83. Lee SH, Ko YG, Jang Y, Kwon HM, Lee SH, Yoon JH, Park SH, Kim BO, Jeon DW, Yang JY, Ryu SK, Korean Multicenter Angioplasty Team (KOMATE) Investigators: Sirolimus- versus paclitaxel-eluting stent implantation for unprotected left main coronary artery stenosis. Cardiology; 2005;104(4):181-5
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  • [Title] Sirolimus- versus paclitaxel-eluting stent implantation for unprotected left main coronary artery stenosis.
  • We performed this study in order to compare the immediate and mid-term outcomes of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in lesions of the unprotected left main coronary artery (LMCA).
  • We assessed 54 patients from 5 centers who had undergone unprotected LMCA stenting (35 SES and 19 PES).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blood Vessel Prosthesis Implantation. Coronary Angiography. Coronary Restenosis / etiology. Coronary Restenosis / radiography. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome. Ventricular Dysfunction, Left / radiography. Ventricular Dysfunction, Left / therapy

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16155390.001).
  • [ISSN] 0008-6312
  • [Journal-full-title] Cardiology
  • [ISO-abbreviation] Cardiology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Coated Materials, Biocompatible; 0 / Immunosuppressive Agents; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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84. Shimizu T, Miyakawa Y, Mitsuhashi T, Kakimoto T, Ikeda Y, Kizaki M, Hagiwara T: [Persistent neutrophilia occurring after pneumonia: a differential diagnosis of neutrophilia based on the WHO classification]. Rinsho Ketsueki; 2005 Jul;46(7):532-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Persistent neutrophilia occurring after pneumonia: a differential diagnosis of neutrophilia based on the WHO classification].
  • Bone marrow examination revealed hypercellularity without excess of blasts and hiatus leukemia, accompanied by mild dysplasia in myeloid cells and megakaryocytes.
  • Major/minor BCR-ABL fusion genes were negative by RT-PCR.
  • As previously reported by several investigators, we often experience difficulties in distinguishing atypical CML from CNL and CMML.
  • [MeSH-major] Leukocytosis / classification. Leukocytosis / diagnosis. Neutrophils. Pneumonia, Bacterial / complications
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. World Health Organization

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  • (PMID = 16440748.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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85. Chikwe J, Kim M, Goldstone AB, Fallahi A, Athanasiou T: Current diagnosis and management of left main coronary disease. Eur J Cardiothorac Surg; 2010 Oct;38(4):420-8
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  • [Title] Current diagnosis and management of left main coronary disease.
  • Left main coronary artery (LMCA) disease remains an important risk factor for increased mortality and morbidity at all stages of diagnosis and treatment of coronary artery disease.
  • Left main stem pathology is often silent, with unpredictable presentation: as such it poses diagnostic and management challenges.
  • This article reviews the anatomy, epidemiology and diagnosis of left main stem disease, as well as advances in multidisciplinary concepts of diagnosis and management, and summarises the outcomes of recent prospective studies comparing percutaneous and surgical revascularisation in LMCA disease.
  • [MeSH-major] Coronary Disease / diagnosis

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  • [Copyright] Copyright © 2010. Published by Elsevier B.V.
  • [CommentIn] Eur J Cardiothorac Surg. 2010 Oct;38(4):428-30 [20627754.001]
  • (PMID = 20643559.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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86. Shirai S, Doijiri T, Iwabuchi M: Treatment for LMCA ostial stenosis using a bifurcation technique with a retrograde approach. Catheter Cardiovasc Interv; 2010 Apr 1;75(5):748-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment for LMCA ostial stenosis using a bifurcation technique with a retrograde approach.
  • A 69-year-old man who underwent coronary artery bypass surgery in February 2008.
  • The surgery included grafting of the left internal thoracic artery (LITA) to the diagonal branch (D1) and a saphenous vein graft (SVG) to the left circumflex artery (LCX) due to ostial stenosis of the left main coronary artery (LMCA).
  • Coronary CT revealed that the LITA-D1 graft was patent, the SVG-LCX graft was occluded, and there was severe ostial stenosis of the LMCA.
  • After crossing the LMCA ostial lesion the retrograde wire was snared through antegradely for insertion of the guiding catheter via the right brachial artery.
  • We were able to engage the guiding catheter in the left coronary artery and implant the stent successfully using the antegrade approach.
  • [MeSH-major] Angioplasty, Balloon, Coronary / methods. Coronary Artery Bypass / adverse effects. Coronary Restenosis / therapy. Coronary Stenosis / surgery. Graft Occlusion, Vascular / therapy

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 20088018.001).
  • [ISSN] 1522-726X
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Price MJ, Cristea E, Sawhney N, Kao JA, Moses JW, Leon MB, Costa RA, Lansky AJ, Teirstein PS: Serial angiographic follow-up of sirolimus-eluting stents for unprotected left main coronary artery revascularization. J Am Coll Cardiol; 2006 Feb 21;47(4):871-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serial angiographic follow-up of sirolimus-eluting stents for unprotected left main coronary artery revascularization.
  • OBJECTIVES: This study was performed to evaluate the clinical and serial angiographic outcomes of patients undergoing sirolimus-eluting stent (SES) implantation for unprotected left main coronary artery (LMCA) stenosis.
  • BACKGROUND: The efficacy of SES has led to their expanded use for off-label indications, including LMCA disease.
  • METHODS: Unprotected LMCA intervention with SES was attempted in 50 patients.
  • RESULTS: The target lesion involved the distal LMCA in 47 patients (94%).
  • In-lesion restenosis occurred in 21 patients (42%), was focal in 85% of cases, and in 82% involved the branch ostia, sparing the LMCA itself.
  • Late loss was significantly greater within the left circumflex (LCX) ostium compared to the parent vessel (PV) of the LMCA bifurcation (0.83 +/- 0.89 mm vs. 0.49 +/- 0.72 mm, p = 0.04).
  • CONCLUSIONS: Restenosis is a frequent finding when serial angiographic follow-up is performed after SES implantation for unprotected distal LMCA lesions.

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  • [CommentIn] J Am Coll Cardiol. 2006 Feb 21;47(4):878-81 [16487859.001]
  • [CommentIn] J Am Coll Cardiol. 2006 Oct 17;48(8):1727-8; author reply 1728-9 [17045913.001]
  • (PMID = 16487858.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] W36ZG6FT64 / Sirolimus
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88. Okabe T, Mintz GS, Lee SY, Lee B, Roy P, Steinberg DH, Pinto-Slottow T, Smith KA, Xue Z, Satler LF, Kent KM, Pichard AD, Lindsay J, Waksman R, Weissman NJ: Five-year outcomes of moderate or ambiguous left main coronary artery disease and the intravascular ultrasound predictors of events. J Invasive Cardiol; 2008 Dec;20(12):635-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Five-year outcomes of moderate or ambiguous left main coronary artery disease and the intravascular ultrasound predictors of events.
  • The long-term outcome of a moderately diseased left main coronary artery (LMCA) remains unknown.
  • One hundred and fourteen patients who underwent angiographic and intravascular ultrasound (IVUS) evaluation for moderate LMCA disease (< 50% diameter stenosis) without intervention were followed for 5 years.
  • There were 11 patients who underwent coronary artery bypass graft surgery (CABG) within 30 days of IVUS analysis based on IVUS findings and 3 patients who died of noncardiac diseases during the follow-up period.
  • Six patients (6%) died (1 of cardiac causes and 5 of unknown causes) at a follow up of 31.5 +/- 17.0 months post-IVUS assessment.
  • Two patients (2%) underwent CABG at a follow up of 19.0 +/- 7.1 months.
  • There were no percutaneous LMCA interventions and no myocardial infarctions.
  • Univariate predictors for events were age, mean plaque and media (P&M) area and plaque burden over the entire length of the LMCA lesion, and minimum luminal area (MLA), P&M area, plaque burden, and arc of calcium > 90 degrees at the MLA site.
  • In conclusion, moderately diseased LMCAs had a 5- year event rate of 8%.
  • The occurrence of future events in moderate diseased LMCAs is dependent on the amount of disease at the MLA site.
  • [MeSH-major] Coronary Artery Disease / mortality. Coronary Artery Disease / ultrasonography. Severity of Illness Index. Ultrasonography, Interventional
  • [MeSH-minor] Aged. Angioplasty, Balloon, Coronary / mortality. Cause of Death. Comorbidity. Coronary Angiography. Coronary Artery Bypass / mortality. Female. Follow-Up Studies. Humans. Logistic Models. Male. Middle Aged. Multivariate Analysis. Predictive Value of Tests

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  • [CommentIn] J Invasive Cardiol. 2008 Dec;20(12):640-1 [19057026.001]
  • (PMID = 19057025.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Masuko M, Furukawa T, Abe T, Wada R, Maruyama S, Kitajima T, Shibasaki Y, Toba K, Okada M, Aizawa Y: A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement. Int J Hematol; 2009 Sep;90(2):230-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement.
  • Philadelphia (Ph) chromosome as a result of t (9;. 22) (q34;.
  • q11) is observed in more than 90% of chromic myeloid leukemia (CML) patients.
  • Cases in which the typical Ph chromosome is not visible at the karyotype level comprise 5-10% of CML patients.
  • CML cases with fusion transcripts such as e13a3 in which ABL exon 3 rather than exon 2 has fused to BCR are very rare.
  • Such reported cases with the e13a3 transcript show the Ph chromosome on karyotype analysis.
  • We reported an atypical karyotype CML patient with the e13a3 BCR-ABL transcript caused by complex translocation.
  • [MeSH-major] Fusion Proteins, bcr-abl / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Translocation, Genetic
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Asian Continental Ancestry Group / genetics. Benzamides. Chromosome Aberrations. Female. Humans. Imatinib Mesylate. In Situ Hybridization, Fluorescence. Philadelphia Chromosome. Piperazines / therapeutic use. Pyrimidines / therapeutic use


90. Nomura T, Nakagawa Y, Urakabe Y, Naito D, Enomoto S, Nishikawa S, Keira N, Matsubara H, Tatsumi T: Subacutely progressed extensive aortic dissection complicated with catheter-induced dissection in left main coronary artery. J Cardiol; 2009 Aug;54(1):128-33
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  • [Title] Subacutely progressed extensive aortic dissection complicated with catheter-induced dissection in left main coronary artery.
  • A 64-year-old man complaining of resting angina underwent emergent coronary angiogram and significant stenosis in the mid-left anterior descending artery was discovered.
  • Although deployment of the drug-eluting Cypher stent relieved the stenosis, the guiding catheter accidentally induced coronary dissection in the left main coronary artery (LMCA).
  • 20 days later, although asymptomatic, extensive aortic dissection was detected from the coronary sinus of Valsalva to the femoral artery.
  • 64-Row multidetector computed tomography demonstrated that the dissection originated from the LMCA and retrogradely expanded to the aorta.
  • [MeSH-major] Aneurysm, Dissecting / complications. Aortic Aneurysm / complications. Cardiac Catheterization / adverse effects. Coronary Disease / etiology
  • [MeSH-minor] Coronary Stenosis / therapy. Dissection. Humans. Iatrogenic Disease. Male. Middle Aged

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  • (PMID = 19632532.001).
  • [ISSN] 1876-4738
  • [Journal-full-title] Journal of cardiology
  • [ISO-abbreviation] J Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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91. Karimi M, Murdison K, Blackwood W, Davis W: Reimplantation of anomalous right coronary artery from left main coronary artery: a surgical option. Interact Cardiovasc Thorac Surg; 2010 Apr;10(4):642-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reimplantation of anomalous right coronary artery from left main coronary artery: a surgical option.
  • Anomalous right coronary artery (ARCA) from left sinus of Valsalva could present in several forms either being intramural or extramural, and most occurring with separate ostium from left coronary system.
  • ARCA originating from the left main coronary artery (LMCA) is very rare and treatments proposed for this type of anomaly are pulmonary artery translocation or coronary artery bypass grafting (CABG) of the right coronary system.
  • There has not been any report in the literature of successful reimplantation of ARCA from LMCA, to the best of our knowledge, as another surgical option for this anomaly.
  • We are reporting a case of successful surgical reimplantation of an ARCA from LMCA.

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  • (PMID = 20061336.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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92. Lee JY, Park DW, Yun SC, Lee SW, Kim YH, Lee CW, Hong MK, Park SW, Park SJ: Long-term clinical outcomes of sirolimus- versus paclitaxel-eluting stents for patients with unprotected left main coronary artery disease: analysis of the MAIN-COMPARE (revascularization for unprotected left main coronary artery stenosis: comparison of percutaneous coronary angioplasty versus surgical revascularization) registry. J Am Coll Cardiol; 2009 Aug 25;54(9):853-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term clinical outcomes of sirolimus- versus paclitaxel-eluting stents for patients with unprotected left main coronary artery disease: analysis of the MAIN-COMPARE (revascularization for unprotected left main coronary artery stenosis: comparison of percutaneous coronary angioplasty versus surgical revascularization) registry.
  • OBJECTIVES: The aim of this study was to evaluate long-term clinical outcomes after implantation of sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES) among patients with unprotected left main coronary artery (LMCA) disease.
  • BACKGROUND: There have been few comparisons of long-term outcomes among currently available drug-eluting stents (DES) for the treatment of LMCA disease.
  • METHODS: A total of 858 consecutive patients with unprotected LMCA stenosis were treated with SES (n = 669) or PES (n = 189) between May 2003 and June 2006.
  • CONCLUSIONS: In consecutive patients with unprotected LMCA disease undergoing DES implantation, SES and PES showed similar long-term clinical outcomes in terms of death, MI, repeat revascularization, and stent thrombosis.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy. Coronary Stenosis / therapy. Paclitaxel / administration & dosage. Sirolimus / administration & dosage

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  • [Copyright] 2009 by the American College of Cardiology Foundation
  • (PMID = 19695467.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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93. Rogers IS, Rinaldi MJ, Humphrey CB, Boden WE, Dougherty JE: Postpartum dissection of the left main coronary artery. Clin Cardiol; 2006 Apr;29(4):175-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postpartum dissection of the left main coronary artery.
  • Peripartum coronary artery dissection is rare, but it is an increasingly recognized risk to women of childbearing age.
  • Literature reviews reveal that about 80% of the population with spontaneous coronary artery dissections (SCAD) are female, and approximately 25-33% of cases occurred while the woman was pregnant or in the peripartum phase.
  • The left anterior descending is the most commonly affected vessel.
  • Presently, stenting appears to be best employed in the patients who have single-vessel dissection not involving the left main coronary artery (LMCA).
  • Surgical revascularization via coronary artery bypass graft remains the optimal therapy in patients whose dissection involves the LMCA, in patients with concurrent multivessel dissection, and in patients with disease refractory to medical management.
  • It is important to consider coronary artery dissection in the differential of any young woman who presents with signs or symptoms consistent with acute coronary syndrome, particularly if she is peripartum.
  • [MeSH-major] Aneurysm, Dissecting / diagnosis. Coronary Aneurysm / diagnosis. Puerperal Disorders / diagnosis
  • [MeSH-minor] Adult. Coronary Angiography. Coronary Artery Bypass. Diagnosis, Differential. Electrocardiography. Emergency Treatment. Female. Humans. Pregnancy

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  • (PMID = 16649728.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Park DW, Kim YH, Yun SC, Lee JY, Kim WJ, Kang SJ, Lee SW, Lee CW, Kim JJ, Choo SJ, Chung CH, Lee JW, Park SW, Park SJ: Long-term outcomes after stenting versus coronary artery bypass grafting for unprotected left main coronary artery disease: 10-year results of bare-metal stents and 5-year results of drug-eluting stents from the ASAN-MAIN (ASAN Medical Center-Left MAIN Revascularization) Registry. J Am Coll Cardiol; 2010 Oct 19;56(17):1366-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term outcomes after stenting versus coronary artery bypass grafting for unprotected left main coronary artery disease: 10-year results of bare-metal stents and 5-year results of drug-eluting stents from the ASAN-MAIN (ASAN Medical Center-Left MAIN Revascularization) Registry.
  • OBJECTIVES: This study sought to evaluate the long-term safety and effectiveness of percutaneous coronary intervention (PCI), as compared with coronary artery bypass grafting (CABG), for unprotected left main coronary artery (LMCA) disease.
  • BACKGROUND: Data on the long-term (beyond 5-year) comparative results of treatment of unprotected LMCA disease with stent implantation or CABG are limited.
  • METHODS: We performed a 10-year clinical follow-up of 350 patients with unprotected LMCA disease who underwent PCI with bare-metal stents (BMS) (n = 100) or CABG (n = 250) from January 1995 to April 1999, and 5-year clinical follow-up of 395 patients with unprotected LMCA disease who underwent PCI with drug-eluting stents (DES) (n = 176) or CABG (n = 219) from January 2003 to May 2004.
  • CONCLUSIONS: For the treatment of unprotected LMCA disease, PCI with stent implantation showed similar long-term mortality and rates of death, Q-wave MI, or stroke.
  • [MeSH-major] Coronary Artery Bypass. Coronary Artery Disease / therapy. Stents
  • [MeSH-minor] Coronary Disease / therapy. Drug-Eluting Stents / adverse effects. Female. Follow-Up Studies. Humans. Male. Middle Aged. Myocardial Infarction / mortality. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20946993.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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96. Abruzzese E, Gozzetti A, Galimberti S, Trawinska MM, Caravita T, Siniscalchi A, Cervetti G, Mauriello A, Coletta AM, De Fabritiis P: Characterization of Ph-negative abnormal clones emerging during imatinib therapy. Cancer; 2007 Jun 15;109(12):2466-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of Ph-negative abnormal clones emerging during imatinib therapy.
  • BACKGROUND: Imatinib is a tyrosine kinase-specific inhibitor widely used for the treatment of chronic myeloid leukemia (CML).
  • Studies reported the occurrence of additional cytogenetic abnormalities in the Philadelphia chromosome (Ph)-negative cell population emerging after treatment-induced suppression of the Ph-positive clone.
  • METHODS: The study involved 13 cases of patients diagnosed with CML carrying cytogenetic abnormalities in their Ph-negative cell population after imatinib treatment.
  • RESULTS: CD34+ cells express the cytogenetic markers present in Ph- cells, suggesting a possible involvement of the stem cell population.
  • No growth advantage was demonstrated for the Ph-negative or the Ph-positive clone after cell culture.
  • CONCLUSIONS: After follow-up of up to 49 months, none of the patients had evolved to myelodysplasia or acute leukemia.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Chromosome Aberrations. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • [Copyright] Copyright 2007 American Cancer Society.
  • (PMID = 17503437.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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97. Namboodiri N, Krishnamoorthy KM: Type A aortic dissection with partial ostial occlusion of left main coronary artery. Eur J Echocardiogr; 2008 Jan;9(1):139-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Type A aortic dissection with partial ostial occlusion of left main coronary artery.
  • The short axis view of the aorta showed partial obstruction of the left main coronary artery (LMCA) by the intimal flap with turbulent flow at its ostium.

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  • (PMID = 17588497.001).
  • [ISSN] 1532-2114
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [General-notes] NLM/ Original DateCompleted: 20080603
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98. Lindstaedt M, Spiecker M, Lawo T, Yazar A, Mügge A, Bojara W, Germing A: [Angiographic assessment of functionally insignificant left main coronary artery stenoses: reliability compared to intracoronary pressure measurement]. Dtsch Med Wochenschr; 2006 Sep 29;131(39):2134-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiographic assessment of functionally insignificant left main coronary artery stenoses: reliability compared to intracoronary pressure measurement].
  • BACKGROUND AND OBJECTIVE: Left main coronary artery disease (LMCA) is still a widely accepted indication for coronary artery bypass surgery.
  • Intermediate LMCA disease, however, often cannot be evaluated reliably on the basis of clinical and angiographic information alone.
  • This study was performed to compare the accuracy of visual angiographic assessment of intermediate LMCA stenoses by experienced interventional cardiologists with functional assessment by FFR in a patient population with excellent long-term outcome after deferral of surgery on the basis of FFR measurements.
  • PATIENTS AND METHODS: 24 of 51 consecutive patients with intermediate LMCA disease were deferred from surgery based on an FFR value of > or = 0.75.
  • CONCLUSION: The functional significance of intermediate or equivocal LMCA lesions should not be based on visual assessment alone, even when performed by experienced interventional cardiologists.
  • [MeSH-major] Blood Pressure / physiology. Blood Pressure Determination / standards. Coronary Angiography / standards. Coronary Circulation / physiology. Coronary Stenosis / diagnosis. Coronary Vessels / physiology

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  • (PMID = 16991027.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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99. Hall J, Foucar K: Diagnosing myelodysplastic/myeloproliferative neoplasms: laboratory testing strategies to exclude other disorders. Int J Lab Hematol; 2010 Dec;32(6 Pt 2):559-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The 2008 World Health Organization classification of myeloid neoplasms includes the diagnostic category, myelodysplastic/myeloproliferative neoplasms (MDS/MPN), which encompasses those rare clonal myeloid proliferations that at initial presentation, show overlapping myeloproliferative and myelodysplastic features, making classification as either a myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) problematic.
  • There are four main subcategories, chronic myelomonocytic leukemia (CMML), atypical chronic myeloid leukemia, BCR-ABL1-negative (aCML), juvenile myelomonocytic leukemia (JMML), and myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U), which also includes the provisional entity, refractory anemia with ring sideroblasts associated with marked thrombocytosis (RARS-T).
  • Notably, the morphological features typical of MDS/MPNs are not specific and can be seen in other myeloid neoplasms at presentation or as part of disease progression or transformation.
  • CONCLUSION: The most appropriate classification of myeloid neoplasms presenting with hybrid myelodysplastic/myeloproliferative features requires a comprehensive clinical and laboratory assessment with careful integration of the morphological, immunophenotypic, genetic, and clinical characteristics.
  • [MeSH-major] Myelodysplastic Syndromes / diagnosis. Myeloproliferative Disorders / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anemia, Refractory, with Excess of Blasts / diagnosis. Bone Marrow / pathology. Diagnosis, Differential. Erythrocytes / pathology. Female. Flow Cytometry. Granulocytes / pathology. Humans. Immunohistochemistry. Leukemia, Myeloid / diagnosis. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis. Leukemia, Myelomonocytic, Chronic / diagnosis. Leukemia, Myelomonocytic, Juvenile / diagnosis. Male. Megakaryocytes / pathology. Neutrophils / pathology. Proto-Oncogene Proteins c-abl / analysis. Proto-Oncogene Proteins c-bcr / analysis. Thrombocytosis / diagnosis

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  • [Copyright] © 2010 Blackwell Publishing Ltd.
  • (PMID = 20670271.001).
  • [ISSN] 1751-553X
  • [Journal-full-title] International journal of laboratory hematology
  • [ISO-abbreviation] Int J Lab Hematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.2 / Proto-Oncogene Proteins c-abl; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr
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100. Sokmen G, Tuncer C, Sokmen A, Suner A: Clinical and angiographic features of large left main coronary artery aneurysms. Int J Cardiol; 2008 Jan 11;123(2):79-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and angiographic features of large left main coronary artery aneurysms.
  • Coronary artery aneurysms are defined as coronary dilatations which exceed the diameter of normal adjacent segments by 1.5 times.
  • Left main coronary artery (LMCA) is the least frequently involved artery with a prevalence of 0.1%.
  • Majority of coronary artery aneurysms are atherosclerotic in origin.
  • A number of complications have been reported to occur during the course of the disease including thrombosis and distal embolization, myocardial ischemia and/or infarction, dissection, vasospasm, calcification, fistulization and very rarely rupture.
  • Large aneurysms of LMCA represent a potentially fatal condition even without concomitant atherosclerotic coronary disease.
  • Because of rarity of coronary artery aneurysms, it is difficult to standardize treatment.
  • In this article, we presented 4 cases of large LMCA aneurysms with various clinical and angiographic features.
  • [MeSH-major] Coronary Aneurysm / diagnosis. Coronary Angiography

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  • (PMID = 17407794.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 34
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