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1. Namboodiri N, Krishnamoorthy KM: Type A aortic dissection with partial ostial occlusion of left main coronary artery. Eur J Echocardiogr; 2008 Jan;9(1):139-40
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  • [Title] Type A aortic dissection with partial ostial occlusion of left main coronary artery.
  • The short axis view of the aorta showed partial obstruction of the left main coronary artery (LMCA) by the intimal flap with turbulent flow at its ostium.

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  • (PMID = 17588497.001).
  • [ISSN] 1532-2114
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [General-notes] NLM/ Original DateCompleted: 20080603
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2. Lindstaedt M, Spiecker M, Lawo T, Yazar A, Mügge A, Bojara W, Germing A: [Angiographic assessment of functionally insignificant left main coronary artery stenoses: reliability compared to intracoronary pressure measurement]. Dtsch Med Wochenschr; 2006 Sep 29;131(39):2134-8
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  • [Title] [Angiographic assessment of functionally insignificant left main coronary artery stenoses: reliability compared to intracoronary pressure measurement].
  • BACKGROUND AND OBJECTIVE: Left main coronary artery disease (LMCA) is still a widely accepted indication for coronary artery bypass surgery.
  • Intermediate LMCA disease, however, often cannot be evaluated reliably on the basis of clinical and angiographic information alone.
  • This study was performed to compare the accuracy of visual angiographic assessment of intermediate LMCA stenoses by experienced interventional cardiologists with functional assessment by FFR in a patient population with excellent long-term outcome after deferral of surgery on the basis of FFR measurements.
  • PATIENTS AND METHODS: 24 of 51 consecutive patients with intermediate LMCA disease were deferred from surgery based on an FFR value of > or = 0.75.
  • CONCLUSION: The functional significance of intermediate or equivocal LMCA lesions should not be based on visual assessment alone, even when performed by experienced interventional cardiologists.
  • [MeSH-major] Blood Pressure / physiology. Blood Pressure Determination / standards. Coronary Angiography / standards. Coronary Circulation / physiology. Coronary Stenosis / diagnosis. Coronary Vessels / physiology

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  • (PMID = 16991027.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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3. Hall J, Foucar K: Diagnosing myelodysplastic/myeloproliferative neoplasms: laboratory testing strategies to exclude other disorders. Int J Lab Hematol; 2010 Dec;32(6 Pt 2):559-71
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  • INTRODUCTION: The 2008 World Health Organization classification of myeloid neoplasms includes the diagnostic category, myelodysplastic/myeloproliferative neoplasms (MDS/MPN), which encompasses those rare clonal myeloid proliferations that at initial presentation, show overlapping myeloproliferative and myelodysplastic features, making classification as either a myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) problematic.
  • There are four main subcategories, chronic myelomonocytic leukemia (CMML), atypical chronic myeloid leukemia, BCR-ABL1-negative (aCML), juvenile myelomonocytic leukemia (JMML), and myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U), which also includes the provisional entity, refractory anemia with ring sideroblasts associated with marked thrombocytosis (RARS-T).
  • Notably, the morphological features typical of MDS/MPNs are not specific and can be seen in other myeloid neoplasms at presentation or as part of disease progression or transformation.
  • CONCLUSION: The most appropriate classification of myeloid neoplasms presenting with hybrid myelodysplastic/myeloproliferative features requires a comprehensive clinical and laboratory assessment with careful integration of the morphological, immunophenotypic, genetic, and clinical characteristics.
  • [MeSH-major] Myelodysplastic Syndromes / diagnosis. Myeloproliferative Disorders / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anemia, Refractory, with Excess of Blasts / diagnosis. Bone Marrow / pathology. Diagnosis, Differential. Erythrocytes / pathology. Female. Flow Cytometry. Granulocytes / pathology. Humans. Immunohistochemistry. Leukemia, Myeloid / diagnosis. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis. Leukemia, Myelomonocytic, Chronic / diagnosis. Leukemia, Myelomonocytic, Juvenile / diagnosis. Male. Megakaryocytes / pathology. Neutrophils / pathology. Proto-Oncogene Proteins c-abl / analysis. Proto-Oncogene Proteins c-bcr / analysis. Thrombocytosis / diagnosis

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  • [Copyright] © 2010 Blackwell Publishing Ltd.
  • (PMID = 20670271.001).
  • [ISSN] 1751-553X
  • [Journal-full-title] International journal of laboratory hematology
  • [ISO-abbreviation] Int J Lab Hematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.2 / Proto-Oncogene Proteins c-abl; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr
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4. Sokmen G, Tuncer C, Sokmen A, Suner A: Clinical and angiographic features of large left main coronary artery aneurysms. Int J Cardiol; 2008 Jan 11;123(2):79-83
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  • [Title] Clinical and angiographic features of large left main coronary artery aneurysms.
  • Coronary artery aneurysms are defined as coronary dilatations which exceed the diameter of normal adjacent segments by 1.5 times.
  • Left main coronary artery (LMCA) is the least frequently involved artery with a prevalence of 0.1%.
  • Majority of coronary artery aneurysms are atherosclerotic in origin.
  • A number of complications have been reported to occur during the course of the disease including thrombosis and distal embolization, myocardial ischemia and/or infarction, dissection, vasospasm, calcification, fistulization and very rarely rupture.
  • Large aneurysms of LMCA represent a potentially fatal condition even without concomitant atherosclerotic coronary disease.
  • Because of rarity of coronary artery aneurysms, it is difficult to standardize treatment.
  • In this article, we presented 4 cases of large LMCA aneurysms with various clinical and angiographic features.
  • [MeSH-major] Coronary Aneurysm / diagnosis. Coronary Angiography

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  • (PMID = 17407794.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 34
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5. Topaz O, Polkampally PR, Mohanty PK, Rizk M, Bangs J, Bernardo NL: Excimer laser debulking for percutaneous coronary intervention in left main coronary artery disease. Lasers Med Sci; 2009 Nov;24(6):955-60
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  • [Title] Excimer laser debulking for percutaneous coronary intervention in left main coronary artery disease.
  • Excimer laser has been successfully applied to complex atherosclerotic plaques in acute coronary syndromes; however, its role in debulking in left main coronary artery disease has not been fully explored.
  • Details of a series of 20 patients who underwent excimer laser revascularization of a spectrum of left main coronary artery lesions are presented.
  • The left main coronary artery was characterized as protected, semi-protected, poorly protected, or unprotected, depending on the presence or absence of patent bypass grafts to the left anterior descending (LAD) and circumflex (CX) arteries.
  • A fully protected left main coronary artery (LMCA) was present in only 20% of the patients.
  • The target lesions included 11(55%) distal LMCA stenoses, six (30%) ostial stenoses, and one (5%) mid-portion lesions.
  • Two (10%) patients had in-stent re-stenosis of the entire length of the LMCA.
  • Successful LMCA intervention was performed in 19 (95%) patients, while in-hospital complications occurred in only one (5%) patient.
  • Subacute/late stent thrombosis developed 3 months after the procedure in one patient, and two patients died from non-cardiac causes during follow-up.
  • Lesions in LMCAs can be revascularized in selected patients by laser debulking and adjunct stenting.
  • Inadequate protection by bypass grafts and decreased left ventricular function do not contradict utilization of excimer laser.
  • Small laser catheters and high energy levels are required during laser debulking of stenoses of left main coronary arteries.
  • [MeSH-major] Angioplasty, Balloon, Laser-Assisted / methods. Coronary Artery Disease / therapy. Lasers, Excimer / therapeutic use

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  • (PMID = 19238505.001).
  • [ISSN] 1435-604X
  • [Journal-full-title] Lasers in medical science
  • [ISO-abbreviation] Lasers Med Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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6. Nassar H, Gotsman I, Gerganski P, Moseri M, Lotan C, Gotsman M: Cutting balloon angioplasty and stent implantation for aorto-ostial lesions: clinical outcome and 1-year follow-up. Clin Cardiol; 2009 Apr;32(4):183-6
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  • BACKGROUND: Percutaneous interventions for aorto-ostial narrowing of native coronary arteries are challenging because of early elastic recoil after the procedure and the high restenosis rate.
  • HYPOTHESIS: The purpose of the study was to evaluate the clinical outcomes of cutting balloon angioplasty and stent implantation for aorto-ostial lesions with a 1-year clinical follow-up.
  • RESULTS: Forty-eight patients underwent balloon angioplasty; 36 of whom had lesions in the ostial right coronary artery, and 12 of whom had lesions in the left main coronary artery (LMCA).
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy. Stents

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  • (PMID = 19353700.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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7. Kim JW, Seo HS, Rha SW, Park CG, Oh DJ: Acute myocardial infarction in a 14-year old boy by thrombotic occlusion of the left main coronary ostium. Int J Cardiol; 2006 Mar 8;107(3):430-1
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  • [Title] Acute myocardial infarction in a 14-year old boy by thrombotic occlusion of the left main coronary ostium.
  • We report the case of a 14-year old boy who was diagnosed with acute myocardial infarction complicated by cardiogenic shock and was treated by primary stenting of thrombotic occluded left main ostium.
  • A prompt stenting to the LMCA saved patient's life.

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  • (PMID = 16503272.001).
  • [ISSN] 0167-5273
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
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8. Huang HC, Kao HL, Wu XM, Wang SS, Hsu RB, Ho YL, Chen MF: Long-term prognosis in ethnic Chinese patients with unprotected left main coronary artery disease. Clin Res Cardiol; 2010 Jul;99(7):437-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term prognosis in ethnic Chinese patients with unprotected left main coronary artery disease.
  • OBJECTIVE: The aim of this study was to investigate the long-term outcome of unprotected left main coronary artery disease (LMCA) with different therapeutic modalities in Chinese patients.
  • BACKGROUND: Coronary artery bypass graft (CABG) has been considered standard therapy for patients with LMCA disease.
  • Percutaneous coronary intervention (PCI) has recently been alternative choice for unprotected LMCA.
  • Nevertheless, the effects on the long-term outcome of unprotected LMCA by the above-mentioned management in Chinese remains unknown.
  • METHODS: Patients with unprotected LMCA were enrolled at National Taiwan University Hospital from January 1996 to June 2006.
  • In high-risk left ventricular dysfunction, the elderly and renal insufficiency patients, the long-term survival was statistically significantly better in the CABG group.
  • CONCLUSION: For Chinese patients with unprotected left main coronary artery disease, a significant higher risk of cardiovascular death was noted in the medical therapy group.
  • Overall the long-term cardiovascular survival was similar in LMCA patients treated with either PCI or CABG, but CABG provided better survival outcome in high-risk subgroup patients.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Asian Continental Ancestry Group / statistics & numerical data. Coronary Artery Bypass. Coronary Artery Disease / therapy

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  • (PMID = 20229255.001).
  • [ISSN] 1861-0692
  • [Journal-full-title] Clinical research in cardiology : official journal of the German Cardiac Society
  • [ISO-abbreviation] Clin Res Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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9. Hong YJ, Mintz GS, Kim SW, Lu L, Bui AB, Pichard AD, Satler LF, Waksman R, Kent KM, Suddath WO, Weissman NJ: Impact of remodeling on cardiac events in patients with angiographically mild left main coronary artery disease. J Invasive Cardiol; 2007 Dec;19(12):500-5
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  • [Title] Impact of remodeling on cardiac events in patients with angiographically mild left main coronary artery disease.
  • BACKGROUND: The clinical significance of intravascular ultrasound (IVUS) assessed remodeling in left main coronary artery (LMCA) lesions has not been studied.
  • Thus, we evaluated the impact of coronary arterial remodeling on cardiac events in patients with angiographically mild LMCA disease.
  • METHODS: Two hundred thirty-six patients who underwent IVUS evaluation to determine the severity of angiographically mild LMCA lesions (diameter stenosis < 50%) were included.
  • Negative remodeling (NR) was defined as a remodeling index (lesion/reference external elastic membrane crosssectional area [CSA]) < 0.95, intermediate remodeling (IR) as between 0.95-1.05, and positive remodeling (PR) as > 1.05.
  • At 1-year follow up, LMCA-related cardiac events occurred in 15 patients (6.3%).
  • NR was less frequently associated with LMCA-related cardiac events than IR/PR [6/156 (3.8%) vs. 9/80 (11.3%); p = 0.027].
  • In lesions associated with LMCA-related events, lumen CSA was smaller, plaque burden was larger, and the remodeling index was greater than in lesions not associated with cardiac events, but only non-NR was an independent predictor of LMCA-related events in patients with mild LMCA disease (hazard ratio 4.095; 95% CI, 1.275-13.149; p = 0.018).
  • CONCLUSIONS: Angiographically mild LMCA disease was more frequently associated with NR, and NR was associated with fewer LMCA-related cardiac events in patients with mild LMCA lesions.
  • [MeSH-major] Coronary Angiography / methods. Coronary Disease / radiography. Coronary Vessels / physiopathology
  • [MeSH-minor] Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Ultrasonography, Interventional

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  • (PMID = 18180518.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Kim HW, Lee SS, Ryu MH, Lee JL, Chang HM, Kim TW, Chi HS, Kim WK, Lee JS, Kang YK: A case of leukemic pleural infiltration in atypical chronic myeloid leukemia. J Korean Med Sci; 2006 Oct;21(5):936-9
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  • [Title] A case of leukemic pleural infiltration in atypical chronic myeloid leukemia.
  • Pleural effusion in chronic myeloid leukemia (CML) is poorly understood and rarely reported in the literature.
  • We report here a case of bilateral pleural involvement of atypical CML in an 83-yr old male diagnosed with pancreatic cancer with abdominal wall metastasis and incidental peripheral leukocytosis.
  • Based on bone marrow examination, chromosome analysis and polymerase chain reaction he was diagnosed with Philadelphia chromosome negative, BCR/ABL gene rearrangement negative CML.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Leukemic Infiltration / pathology. Pleural Effusion / etiology


11. Imamaki M, Matsuura K, Sakurai M, Shimura H, Ishida A, Miyazaki M: Evaluation of early and midterm results of offpump coronary artery bypass in patients with left main disease. J Card Surg; 2009 Mar-Apr;24(2):162-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of early and midterm results of offpump coronary artery bypass in patients with left main disease.
  • PURPOSE: This study evaluated the early and midterm results of offpump coronary artery bypass (OPCAB) for left main coronary artery (LMCA) stenosis.
  • METHODS: Patients treated between November 2001 and December 2006, during which isolated coronary artery bypass grafting (CABG) was performed without cardiopulmonary bypass in principle, were included.
  • Isolated CABG was performed in 206 patients, of whom 62 (30.1%) had LMCA stenosis >50%.
  • RESULTS: The in-hospital mortality rate (LMCA stenosis > 50%, 1.6%; LMCA stenosis <or=50%, 0.7%, p = 0.512), the incidence of postoperative complications, and the midterm survival rate (LMCA stenosis succeeds50%, 86.7 +/- 5.2%/5 years, LMCA stenosis<or=50%, 89.6 +/- 3.8%/5 years, p = 0.21) did not significantly differ between the two groups.
  • Conversion was significantly frequent in patients with LMCA stenosis >75% and severe stenosis >90% in the right coronary artery (RCA) trunk.
  • CONCLUSIONS: Patients with LMCA stenosis can undergo OPCAB safely and the midterm results are good.
  • As conversion was significantly frequent in patients with severe LMCA and RCA trunk stenosis, adequate preparation for pump application is necessary.
  • [MeSH-major] Coronary Artery Bypass, Off-Pump / statistics & numerical data. Coronary Stenosis / surgery

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  • (PMID = 19267825.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Mahesh B, Navaratnarajah M, Mensah K, Amrani M: Treatment of high-output coronary artery fistula by off-pump coronary artery bypass grafting and ligation of fistula. Interact Cardiovasc Thorac Surg; 2009 Jul;9(1):124-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of high-output coronary artery fistula by off-pump coronary artery bypass grafting and ligation of fistula.
  • Coronary artery fistulas (CAF) are uncommon entities often associated with myocardial ischemia and high output failure.
  • Surgical options include ligation of the fistula, with/without simultaneous coronary artery bypass grafting (CABG).
  • We report a case of left main coronary artery (LMCA) fistula to the coronary sinus (CS), which was associated with high-output bi-ventricular failure, and moderate mitral (MR) and tricuspid regurgitation (TR), related to the volume overload and annular dilatation.
  • This was tackled elegantly by off-pump CABG to protect the territories supplied by the LMCA, followed by ligation of the fistula.
  • [MeSH-major] Arteriovenous Fistula / surgery. Cardiac Output, High / surgery. Coronary Artery Bypass, Off-Pump. Coronary Sinus / surgery

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  • (PMID = 19346222.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Inan BK, Ucak A, Gullu AU, Temizkan V, Ugur M, Yilmaz AT: Left main coronary artery and supravalvular aortic stenosis in adult: treatment with ostial patchplasty and modified Brom procedure. J Card Surg; 2009 May-Jun;24(3):299-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Left main coronary artery and supravalvular aortic stenosis in adult: treatment with ostial patchplasty and modified Brom procedure.
  • Left main coronary artery (LMCA) stenosis accompanying to supravalvular aortic stenosis is a very uncommon, serious congenital abnormality.
  • Aortic valve leaflet fusions and intimal thickening of the aortic valve leaflets and coronary artery are the underlying pathologies for the LMCA stenosis.
  • We operated on a 21-year-old male patient for supravalvar aortic stenosis with LMCA ostial stenosis.
  • We enlarged the LMCA with a pericardial patch (ostial plasty) and reconstructed the aortic root with a modified Brom procedure.
  • Postoperative course was uneventful; echocardiographic evaluation revealed a normal functioning aortic valve with a normal left ventricular function.
  • Gradient at left ventricular outflow tract was decreased a great deal.
  • Although supravalvular aortic stenosis with LMCA stenosis is a very rare congenital abnormality, this clinical entity can be successfully corrected with detailed and selected surgical procedures.

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  • (PMID = 19438785.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polyethylene Terephthalates
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14. Tatli E: Thrombotic occlusion of the ostial left main coronary artery in a patient with acute coronary syndrome. Neth Heart J; 2009 Aug;17(7-8):295-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thrombotic occlusion of the ostial left main coronary artery in a patient with acute coronary syndrome.
  • Ostial left main coronary artery (LMCA) occlusion is rarely seen in patients with acute coronary syndrome.
  • Acute coronary syndrome resulting from an LMCA occlusion is associated with a significant morbidity and mortality rate, if it is managed with fibrinolysis.
  • Electrocardiography can predict LMCA occlusion in patients with acute coronary syndrome.
  • We report a 52-year-old male who presented with acute coronary syndrome and ostial LMCA occlusion. (Neth Heart J 2009;17:295-6.).

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  • [Cites] Int J Cardiol. 2007 Apr 4;116(3):e83-4 [17126932.001]
  • [Cites] Jpn Heart J. 2000 Sep;41(5):571-81 [11132164.001]
  • [Cites] J Am Coll Cardiol. 2001 Nov 1;38(5):1348-54 [11691506.001]
  • [Cites] Int Heart J. 2006 Jan;47(1):13-20 [16479036.001]
  • (PMID = 19789699.001).
  • [ISSN] 1568-5888
  • [Journal-full-title] Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
  • [ISO-abbreviation] Neth Heart J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2743820
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15. Lehmann R, Spyridopoulos I, Kremer J, Zeiher AM, Schächinger V, Fichtlscherer S: Favorable long-term survival in patients undergoing stent PCI of unprotected left main coronary artery compared to predicted short-term prognosis of CABG estimated by EuroSCORE: clinical determinants of long-term outcome. J Interv Cardiol; 2009 Aug;22(4):311-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Favorable long-term survival in patients undergoing stent PCI of unprotected left main coronary artery compared to predicted short-term prognosis of CABG estimated by EuroSCORE: clinical determinants of long-term outcome.
  • AIMS/METHODS: The long-term outcome of patients (pts) undergoing percutaneous coronary intervention (PCI) of unprotected left main coronary artery (LMCA) is unclear so far.
  • We prospectively investigated the outcome of 102 consecutive patients who underwent stent PCI of unprotected LMCA.
  • Patients were divided according to clinical indication for PCI: stable coronary artery disease (CAD) (N = 60), NSTEMI (N = 18), STEMI (N = 24).
  • Expected in-hospital mortality of coronary artery bypass grafting (CABG) was calculated using the European System for Cardiac Operative Risk Evaluation (EuroSCORE) and compared to the observed survival rate during long-term follow-up (mean 1.8 +/- 1.2 years).
  • Prognostically relevant patient related factors (P < 0.01) included severely reduced left ventricular ejection fraction (HR 3.24), ACS (HR 3.18), STEMI (HR: 3.01), Killip class IV (HR 7.69), occurrence of neoplastic disease (HR 3.97), and elevated CRP (HR 3.86).
  • CONCLUSIONS: LMCA-PCI was associated with lower long-term mortality rates compared to the estimated mortality of CABG.
  • This prospective observational study suggests that DES-PCI of unprotected LMCA in "all-comers" can be carried out with reasonable risk.
  • [MeSH-major] Angioplasty, Balloon, Coronary / mortality. Coronary Artery Bypass / mortality. Coronary Artery Disease / therapy. Coronary Vessels / pathology. Stents


16. Leesar MA, Mintz GS: Hemodynamic and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosis. Catheter Cardiovasc Interv; 2007 Nov 1;70(5):721-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hemodynamic and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosis.
  • The assessment of the left main coronary artery (LMCA) stenosis by angiography is not reliable, and noninvasive tests are incapable of discriminating ischemia caused by LMCA versus other stenoses.
  • Among patients with LMCA stenosis, both fractional flow reserve and intravascular ultrasound parameters would determine the severity of stenosis and predict the event rates.
  • This review outlines the evidence in support of their routine use for the assessment of an ambiguous LMCA stenosis.

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17960644.001).
  • [ISSN] 1522-1946
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Lindsey JB, Brilakis ES, Banerjee S: Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention. Cardiovasc Revasc Med; 2008 Jan-Mar;9(1):47-51
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  • [Title] Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention.
  • A patient with severe pulmonary (arterial) hypertension (PH) presented with a non-ST segment elevation myocardial infarction and recurrent angina at rest.
  • Coronary angiography showed severe ostial left main coronary artery (LMCA) stenosis; coronary arteries were otherwise normal.
  • Intravascular ultrasonography (IVUS) showed deformation of the LMCA due to extrinsic compression from a markedly dilated main pulmonary artery, which was confirmed by cardiac computed tomography.
  • The LMCA was successfully stented using a paclitaxel-eluting stent resulting in complete resolution of angina.
  • Extrinsic compression of the LMCA should be considered in patients with severe PH and angina; IVUS may aid in the diagnosis.
  • [MeSH-major] Acute Coronary Syndrome / therapy. Angioplasty, Balloon, Coronary. Coronary Stenosis / therapy. Hypertension, Pulmonary / complications. Pulmonary Artery / pathology

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  • (PMID = 18206638.001).
  • [ISSN] 1878-0938
  • [Journal-full-title] Cardiovascular revascularization medicine : including molecular interventions
  • [ISO-abbreviation] Cardiovasc Revasc Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cardiovascular Agents; 0 / Platelet Aggregation Inhibitors; P88XT4IS4D / Paclitaxel
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18. Burzotta F, Trani C, Coroleu S: Retrograde recanalization of left main from saphenous vein graft supported by percutaneous Impella Recover LP 2.5 assist device. J Invasive Cardiol; 2009 Aug;21(8):E147-50
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  • [Title] Retrograde recanalization of left main from saphenous vein graft supported by percutaneous Impella Recover LP 2.5 assist device.
  • Percutaneous coronary interventions (PCI) in patients with severely depressed left ventricular (LV) function and in those with chronic total occlusions are technically challenging and at high risk of complications.
  • Here we report a case of successful retrograde transradial recanalization and stenting of a chronically occluded left main coronary artery (LMCA) from a saphenous vein graft supported by the Impella Recover LP 2.5 assist device.

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  • (PMID = 19652264.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Ozmen N, Yiginer O, Uz O, Kardesoglu E, Aparci M, Isilak Z, Cingozbay BY, Cebeci BS, Kocum HT: ST elevation in the lead aVR during exercise treadmill testing may indicate left main coronary artery disease. Kardiol Pol; 2010 Oct;68(10):1107-11
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  • [Title] ST elevation in the lead aVR during exercise treadmill testing may indicate left main coronary artery disease.
  • BACKGROUND: exercise treadmill testing (ETT) is the most widely used method for evaluating patients with coronary artery disease.
  • Predicting the left main coronary artery (LMCA) disease before invasive procedures is very important in risk assessment because of its severe clinical outcome.
  • AIM: To examine whether ST elevation in lead aVR during ETT may suggest LMCA disease since the lead aVR is the reciprocal lead of LMCA.
  • RESULTS: coronary angiography in the study group revealed significant LMCA stenosis in 16 (76%) patients, whereas LMCA disease was present in only 3 (8%) patients from the control group.
  • There was no significant coronary artery stenosis in 5 patients in the study group and 12 patients in the control group.
  • Of the 16 patients who had LMCA stenosis, 9 had isolated LMCA disease and 7 had additional stenotic lesions in LAD or circumflex coronary arteries.
  • The values of positive and negative predictive value of this finding in diagnosing the presence of LMCA were 76% and 93%, respectively.
  • CONCLUSIONS: ST segment elevation in lead aVR during ETT may point to a high probability of the presence of LMCA disease.
  • [MeSH-major] Coronary Stenosis / diagnosis. Coronary Vessels / pathology. Electrocardiography. Exercise Test

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  • [CommentIn] Kardiol Pol. 2010 Oct;68(10):1112-4 [20967705.001]
  • (PMID = 20967704.001).
  • [ISSN] 0022-9032
  • [Journal-full-title] Kardiologia polska
  • [ISO-abbreviation] Kardiol Pol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
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20. Dragu R, Kerner A, Gruberg L, Rispler S, Lessick J, Ghersin E, Litmanovich D, Engel A, Beyar R, Roguin A: Angiographically uncertain left main coronary artery narrowings: correlation with multidetector computed tomography and intravascular ultrasound. Int J Cardiovasc Imaging; 2008 Jun;24(5):557-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiographically uncertain left main coronary artery narrowings: correlation with multidetector computed tomography and intravascular ultrasound.
  • BACKGROUND: Angiographic assessment of left main coronary artery (LMCA) stenosis is often difficult and unreliable.
  • To date, intravascular ultrasound (IVUS) is used to determine the significance of lesions in patients with LMCA stenosis of uncertain significance.
  • We aimed to prospectively show the ability of multidetector computed tomography (MDCT) to assess LMCA luminal and plaque dimensions, and to characterize atherosclerotic plaque, as compared to IVUS and quantitative coronary angiography (QCA), in patients with angiographically uncertain LMCA stenosis.
  • METHODS: Twenty patients, with angiographically uncertain LMCA stenosis, underwent coronary evaluation with IVUS, QCA and 16-slice MDCT.
  • CONCLUSION: A high degree of correlation was found between MDCT and IVUS regarding the assessment of minimal lumen diameter and area, lumen area stenosis and plaque burden as well as plaque characterization in patients with angiographically borderline LMCA stenosis.
  • Therefore, in patients selected for non-invasive coronary tree evaluation, MDCT may provide a valuable tool for the assessment, decision-making and follow-up of patients with uncertain LMCA disease.

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  • (PMID = 18165931.001).
  • [ISSN] 1569-5794
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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21. Duygu H, Yavuzgil O, Erturk U, Zoghi M, Ozerkan F: ST-segment elevation in lead augmented vector right may also be caused by diffuse left main coronary artery vasospasm without fixed stenosis. Clin Cardiol; 2008 Apr;31(4):179-82
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  • [Title] ST-segment elevation in lead augmented vector right may also be caused by diffuse left main coronary artery vasospasm without fixed stenosis.
  • The ST-segment elevation in this aVR in the patient with clinically suspected acute coronary syndrome suggests a strong possibility of left main coronary artery (LMCA) obstruction due to fixed stenosis.
  • In this article, we report the first case, to our knowledge, of ST-segment elevation in lead aVR due to diffuse LMCA spasm.
  • [MeSH-major] Coronary Vasospasm / diagnosis. Electrocardiography
  • [MeSH-minor] Acute Coronary Syndrome / diagnosis. Angina Pectoris. Coronary Angiography. Coronary Stenosis / complications. Humans. Male. Middle Aged

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18404728.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Cohenpour M, Tourovski A, Zyssman I, Friedensohn A, Gayer G, Horne T: Anomalous origin of left main coronary artery: the value of myocardial scintigraphic and spiral computed tomography scans. Nucl Med Rev Cent East Eur; 2006;9(1):69-71
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  • [Title] Anomalous origin of left main coronary artery: the value of myocardial scintigraphic and spiral computed tomography scans.
  • Anomalous origin of the left main coronary artery (LMCA) from the right sinus of the Valsalva or the proximal right coronary artery (RCA) is one of the most clinically important anomalies of coronary circulation.
  • The exact anatomic course of anomalous LMCA was confirmed using contrast enhanced computed tomography.
  • [MeSH-minor] Adult. Coronary Angiography. Coronary Vessel Anomalies / diagnosis. Coronary Vessel Anomalies / pathology. Female. Humans. Perfusion. Thallium / pharmacology. Tomography, Emission-Computed, Single-Photon / methods

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  • (PMID = 16791809.001).
  • [ISSN] 1506-9680
  • [Journal-full-title] Nuclear medicine review. Central & Eastern Europe
  • [ISO-abbreviation] Nucl Med Rev Cent East Eur
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] AD84R52XLF / Thallium
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23. Fukuhara T, Kakinoki Y: [Clinical features of a new category, myelodysplastic/myeloproliferative diseases, defined by WHO classification]. Rinsho Byori; 2006 Mar;54(3):243-9
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  • The WHO classification published in 2001 defined a new category of hematological disease, myelodysplastic/myeloproliferative diseases (MDS/MPD), that have both myelodysplasia and myeloproliferation at the time of initial presentation.
  • This category consists of four subclasses, chronic myelomonocytic leukemia (CMML), atypical CML(aCML), juvenile chronic myelogenous leukemia and MDS/MPD-unclassifiable (MDS/MPD-u).
  • By reviewing the data of each case according to the criteria, we diagnosed 31 cases of MDS/MPD, including 22 cases of CMML, 5 cases of aCML and 4 cases of MDS/MPD-u.
  • It is noteworthy that blast crisis in CMML exclusively occurred within one year after diagnosis.
  • Young age, a high percentage of blasts in the peripheral blood, splenomegaly, lymphadenopathy and clonal cytogenetic abnormality were associated with blast crisis.
  • It is suggested that there are two subgroups in CMML which differ in disease progression.

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  • (PMID = 16637572.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / Receptors, Immunologic
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24. Chen SL, Ye F, Zhang JJ, Liu ZZ, Lin S, Zhu ZS, Sun XW, Li F, Zhang AP, Chen JG, Ji QJ, Qian J, Chen F, Kwan TW: Distal left main coronary bifurcation lesions predict worse outcome in patients undergoing percutaneous implantation of drug-eluting stents: results from the Drug-Eluting Stent for the Treatment of Left Main Disease (DISTAL) Study. Cardiology; 2009;113(4):264-73
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  • [Title] Distal left main coronary bifurcation lesions predict worse outcome in patients undergoing percutaneous implantation of drug-eluting stents: results from the Drug-Eluting Stent for the Treatment of Left Main Disease (DISTAL) Study.
  • OBJECTIVES: We investigated the clinical outcome of stenting of unprotected left main coronary artery (LMCA).
  • METHODS: We studied 164 patients with nonbifurcated LMCA lesions (group A) and 96 patients with distal bifurcated lesions (group B).
  • There were significant differences in major adverse cardiac events at 1 (p = 0.014) and 2 years (p = 0.002) between group B (19.8%, 25.0%) and group A (9.1%, 10.4%), mainly due to increased target-vessel revascularization (16.7, 21.9% in group B vs. 6.1, 7.3% in group A, p = 0.006 and 0.001, respectively).
  • The double-stent technique was associated with worse outcomes at 1 year in group B compared to group A.
  • Bifurcation lesions (HR 3.42, 95% CI 1.34-5.61, p = 0.001), diabetes (HR 2.68, 95% CI 2.01-12.11, p = 0.015), three-vessel disease (HR 0.83, 95% CI 0.27-0.96, p = 0.001), incomplete revascularization (HR 0.15, 95% CI 0.11-0.35, p = 0.001) and stent diameter (HR 5.05, 95% CI 2.71-10.01, p = 0.03) were the independent factors of major adverse cardiac events in the whole patient cohort.
  • CONCLUSION: Stenting unprotected distal bifurcated LMCA was associated with unfavorable results when compared to stenting other LMCA lesions.
  • [MeSH-major] Angioplasty, Balloon, Coronary / adverse effects. Coronary Angiography. Coronary Artery Disease / radiography. Coronary Artery Disease / therapy. Drug-Eluting Stents / adverse effects
  • [MeSH-minor] Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Predictive Value of Tests. Prevalence. Proportional Hazards Models. Registries. Risk Factors. Stroke Volume. Treatment Failure. Treatment Outcome

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] Cardiology. 2009;113(4):260-3 [19246904.001]
  • (PMID = 19246905.001).
  • [ISSN] 1421-9751
  • [Journal-full-title] Cardiology
  • [ISO-abbreviation] Cardiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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25. Levisman J, Budoff M, Karlsberg R: Congenital atresia of the left main coronary artery: cardiac CT. Catheter Cardiovasc Interv; 2009 Sep 1;74(3):465-7
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  • [Title] Congenital atresia of the left main coronary artery: cardiac CT.
  • Congenital coronary artery disease is a rare occurrence, and atresia of the left main is one of the least frequently observed variations.
  • In a recent review of 1,950 angiograms, 110 congenital coronary anomalies were seen, and of those, only 13 cases represented an absent left main coronary artery (LMCA).
  • This case is of a 53-year-old male who initially presented 2 years prior for atypical chest pain.
  • The anatomy described in this case is typical for LMCA atresia.

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19472349.001).
  • [ISSN] 1522-726X
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Botsios S, Maatz W, Sprengel U, Heuer H, Walterbusch G: Patch angioplasty for isolated ostial stenosis of the left main coronary artery. J Card Surg; 2008 Nov-Dec;23(6):743-6
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  • [Title] Patch angioplasty for isolated ostial stenosis of the left main coronary artery.
  • BACKGROUND: Conventional coronary artery bypass grafting (CABG) is recognized as the treatment of choice for left main coronary artery stenosis (LMCA) with excellent results.
  • Patch angioplasty is an alternative method in selected cases for ostial stenosis of the LMCA.
  • Therefore, the aim of this study was to evaluate the long-term outcome of patients treated by patch angioplasty using saphenous vein for ostial stenosis of the LMCA.
  • METHODS: Nineteen patients underwent vein patch angioplasty for ostial LMCA stenosis between 1995 and 2005 at our institution.
  • On three of them simultaneous aortic valve replacement was carried out and on one patient concomitant coronary artery bypass grafting of the right coronary artery was performed.
  • CONCLUSIONS: Surgical patch angioplasty with saphenous vein for isolated ostial LMCA stenosis is a safe operative technique with good long-term results.
  • MRI is able to adequately depict the operative result of left main coronary ostium reconstruction.

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  • (PMID = 19017004.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Mehilli J, Kastrati A, Byrne RA, Bruskina O, Iijima R, Schulz S, Pache J, Seyfarth M, Massberg S, Laugwitz KL, Dirschinger J, Schömig A, LEFT-MAIN Intracoronary Stenting and Angiographic Results: Drug-Eluting Stents for Unprotected Coronary Left Main Lesions Study Investigators: Paclitaxel- versus sirolimus-eluting stents for unprotected left main coronary artery disease. J Am Coll Cardiol; 2009 May 12;53(19):1760-8
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  • [Title] Paclitaxel- versus sirolimus-eluting stents for unprotected left main coronary artery disease.
  • OBJECTIVES: The aim of this trial was to compare the safety and efficacy of paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) for treatment of unprotected left main coronary artery (uLMCA) disease.
  • METHODS: In this randomized study, 607 patients with symptomatic coronary artery disease undergoing percutaneous coronary intervention for uLMCA were enrolled: 302 were assigned to receive a PES (Taxus, Boston Scientific, Natick, Massachusetts) and 305 assigned to receive a SES (Cypher, Cordis, Johnson & Johnson, New Brunswick, New Jersey).
  • The primary end point was the combined incidence of death, myocardial infarction, and target lesion revascularization (TLR) at 1 year.
  • The secondary end point was angiographic restenosis on the basis of the LMCA area analysis at follow-up angiography.
  • RESULTS: At 1 year the cumulative incidence of death, myocardial infarction, or TLR was 13.6% in the PES and 15.8% in the SES group (relative risk [RR]: 0.85, 95% confidence interval [CI]: 0.56 to 1.29, p = 0.44).
  • CONCLUSIONS: Implantation of either PES or SES in uLMCA lesions is safe and effective; both of these drug-eluting stents provide comparable clinical and angiographic outcomes. (Drug-Eluting-Stents for Unprotected Left Main Stem Disease [ISAR-LEFT-MAIN]; NCT00133237).
  • [MeSH-major] Coronary Artery Disease / drug therapy. Coronary Restenosis / drug therapy. Drug-Eluting Stents. Immunosuppressive Agents / therapeutic use. Paclitaxel / therapeutic use. Sirolimus / therapeutic use. Tubulin Modulators / therapeutic use

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  • [CommentIn] J Am Coll Cardiol. 2009 May 12;53(19):1769-72 [19422983.001]
  • (PMID = 19422982.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00133237
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Platelet Aggregation Inhibitors; 0 / Tubulin Modulators; A74586SNO7 / clopidogrel; OM90ZUW7M1 / Ticlopidine; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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28. Batyraliev TA, Fettser DV, Karben ZA, Sidorenko BA: [Stenting of unprotected left main coronary artery: complications during 3 years follow up]. Kardiologiia; 2009;49(2):22-6
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  • [Title] [Stenting of unprotected left main coronary artery: complications during 3 years follow up].
  • Aim of investigation was to study complications during 3 years follow up of patients after implantation of standard metal stents (SMS) in unprotected left main coronary artery (LMCA).
  • Patients with high risk of surgery (n=124) with stenting of unprotected LMCA performed between August 2002 and November 2004 were included in this investigation.
  • Peripheral complications were noted in 1 case: in one patient pseudoaneurism of femoral artery developed and was successfully resolved by compression under ultrasound control.
  • Despite high success of PCI of unprotected LMCA with the use of SMS and relatively low percent of restenosis it is necessary to use this method carefully in the treatment of patients with lesions in unprotected LMCA.
  • We consider PCI in unprotected LMCA justified only in patients with high risk of surgical intervention who are not suitable candidates for coronary bypass surgery.
  • [MeSH-major] Angioplasty, Balloon, Coronary / methods. Coronary Disease / surgery. Postoperative Complications / epidemiology. Stents

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  • (PMID = 19254212.001).
  • [ISSN] 0022-9040
  • [Journal-full-title] Kardiologiia
  • [ISO-abbreviation] Kardiologiia
  • [Language] rus
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Russia (Federation)
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29. Elder PT, McMullin MF, Humphreys MW, Hamilton J, McGrattan P: The finding of a reciprocal whole-arm translocation t(X;12)(p10;p10) in association with atypical chronic myeloid leukaemia. Med Oncol; 2010 Sep;27(3):760-2
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  • [Title] The finding of a reciprocal whole-arm translocation t(X;12)(p10;p10) in association with atypical chronic myeloid leukaemia.
  • Atypical chronic myeloid leukaemia (aCML) belongs to the myeloproliferative/myelodysplastic category of haematological disease.
  • Main characteristics are marked dysgranulopoiesis, bone marrow dysfunction and the failure to demonstrate the presence of the Philadelphia chromosome or BCR/ABL fusion gene normally associated with CML t(9;22)(q34;q11).
  • Most cases of aCML have one or more karyotypic abnormalities.
  • We highlight a clinical presentation of aCML associated with an acquired reciprocal whole-arm translocation (WAT), t(X;12)(p10;p10), which to our knowledge has not yet been described.
  • [MeSH-major] Chromosomes, Human, Pair 12 / ultrastructure. Chromosomes, Human, X / ultrastructure. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Translocation, Genetic

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  • [Cites] J Clin Pathol. 2008 Aug;61(8):903-8 [18474541.001]
  • [Cites] Leukemia. 1999 May;13(5):671-8 [10374869.001]
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  • (PMID = 19657750.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] RWM8CCW8GP / Octreotide
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30. Ernst T, Chase A, Zoi K, Waghorn K, Hidalgo-Curtis C, Score J, Jones A, Grand F, Reiter A, Hochhaus A, Cross NC: Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms. Haematologica; 2010 Sep;95(9):1473-80
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  • We hypothesized that hitherto unrecognized, cytogenetically cryptic tyrosine kinase fusions may be common in non-classical or atypical myeloproliferative neoplasms and related myelodysplastic/myeloproliferative neoplasms.
  • RESULTS: No abnormalities involving tyrosine kinases were detected; however, nine cytogenetically cryptic copy number imbalances were detected in seven patients, including hemizygous deletions of RUNX1 or CEBPA in two cases with atypical chronic myeloid leukemia.
  • Analysis of other transcription factors known to be frequently mutated in acute myeloid leukemia revealed NPM1 mutations in six (3%) and WT1 mutations in two (1%) patients with myelodysplastic/myeloproliferative neoplasms.
  • [MeSH-minor] CCAAT-Enhancer-Binding Proteins / genetics. Comparative Genomic Hybridization. DNA Mutational Analysis. Gene Dosage. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Myelopoiesis / genetics. Nuclear Proteins / genetics. Prognosis. WT1 Proteins / genetics


31. Kannam HC, Satou G, Gandelman G, DeLuca AJ, Belkin R, Monsen C, Aronow WS, Peterson SJ, Krishnan U: Anomalous origin of the left main coronary artery from the right sinus of Valsalva with an intramural course identified by transesophageal echocardiography in a 14 year old with acute myocardial infarction. Cardiol Rev; 2005 Sep-Oct;13(5):219-22
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  • [Title] Anomalous origin of the left main coronary artery from the right sinus of Valsalva with an intramural course identified by transesophageal echocardiography in a 14 year old with acute myocardial infarction.
  • Coronary artery anomalies have an incidence of 0.6% to 1.3% in angiographic studies and 0.3% in an autopsy series.
  • Anomalous origin of the left main coronary artery (LMCA) from the right sinus of Valsalva (RSOV) represents a small fraction (1.3%) of these anomalies, with an overall prevalence of 0.017% to 0.03% in angiographic studies.
  • We present a case report of a 14-year-old patient with an LMCA arising from the RSOV with an initial intramural course, presenting with acute myocardial infarction (AMI) as the first indication of the anomaly.

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  • (PMID = 16106182.001).
  • [ISSN] 1061-5377
  • [Journal-full-title] Cardiology in review
  • [ISO-abbreviation] Cardiol Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cardiovascular Agents; 69PN84IO1A / Enalapril; GEB06NHM23 / Metoprolol; R16CO5Y76E / Aspirin
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32. Kim SW, Mintz GS, Ohlmann P, Hassani SE, Michalek A, Escolar E, Bui AB, Pichard AD, Satler LF, Kent KM, Suddath WO, Waksman R, Weissman NJ: Comparative intravascular ultrasound analysis of ostial disease in the left main versus the right coronary artery. J Invasive Cardiol; 2007 Sep;19(9):377-80
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  • [Title] Comparative intravascular ultrasound analysis of ostial disease in the left main versus the right coronary artery.
  • BACKGROUND: Significant aorto-ostial disease is difficult to evaluate with angiography and sometimes even with intravascular ultrasound (IVUS).
  • METHODS: We used IVUS to compare ostial lesions in the left main coronary (LMCA, n = 45) versus the right coronary artery (RCA, n = 50).
  • Negative remodeling was defined as a remodeling index (lesion/distal reference arterial area) < 0.95.
  • RESULTS: Patient age was 66 +/- 11 years in the LMCA group and 66 +/- 11 years in the RCA group; 56% of the LMCA ostial lesions and 46% of RCA ostial lesions were in males, and 35% of the LMCA ostial lesions and 20% of the RCA ostial lesions were in diabetics.
  • With the exception of a smaller minimum lumen area (p < 0.0001) and distal reference plaque burden (p = 0.002) in ostial RCA lesions and a larger eccentricity index in ostial LMCA lesions (p = 0.001), both sites were remarkably similar.
  • Both ostial LMCA and RCA lesions were short, had modest amounts of calcium, had modest plaque burdens, but had a marked frequency of negative remodeling (84% in LMCA and 86% in RCA; p = 1.0).
  • CONCLUSION: IVUS morphometry is similar in ostial LMCA and RCA lesions; negative remodeling is the dominant contributor to lumen compromise in both locations.

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  • (PMID = 17827506.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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33. Fassa AA, Wagatsuma K, Higano ST, Mathew V, Barsness GW, Lennon RJ, Holmes DR Jr, Lerman A: Intravascular ultrasound-guided treatment for angiographically indeterminate left main coronary artery disease: a long-term follow-up study. J Am Coll Cardiol; 2005 Jan 18;45(2):204-11
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  • [Title] Intravascular ultrasound-guided treatment for angiographically indeterminate left main coronary artery disease: a long-term follow-up study.
  • OBJECTIVES: The purpose of this study was to evaluate the efficacy of an intravascular ultrasound (IVUS)-guided strategy for patients with angiographically indeterminate left main coronary artery (LMCA) disease.
  • BACKGROUND: The assessment of LMCA lesions using coronary angiography is often challenging; IVUS provides useful information for assessment of coronary disease.
  • METHODS: Intravascular ultrasound was performed on 121 patients with angiographically normal LMCAs to determine the lower range of normal minimum lumen area (MLA), defined as the mean - 2 SD.
  • We conducted IVUS studies on 214 patients with angiographically indeterminate LMCA lesions, and deferral of revascularization was recommended when the MLA was larger than this predetermined value.
  • RESULTS: The lower range of normal LMCA MLA was 7.5 mm(2).
  • Of the patients with angiographically indeterminate LMCAs, 83 (38.8%) had an MLA <7.5 mm(2), and 131 (61.2%) an MLA > or =7.5 mm(2).
  • Left main coronary artery revascularization was performed in 85.5% (71 of 83) of patients with an MLA <7.5 mm(2) and deferred in 86.9% (114 of 131) of patients with an MLA > or =7.5 mm(2).
  • Multivariate predictors of cardiac events were age, smoking, and number of non-LMCA vessels diseased.
  • CONCLUSIONS: Intravascular ultrasound is an accurate method to assess angiographically indeterminate lesions of the LMCA.
  • [MeSH-major] Coronary Artery Disease / therapy. Coronary Artery Disease / ultrasonography. Myocardial Revascularization. Ultrasonography, Interventional


34. Wu XM, Liu CP, Lin WC, Kao HL: Long-term outcome of percutaneous coronary intervention for unprotected left main coronary artery disease. Int J Cardiol; 2010 Feb 4;138(3):272-6
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  • [Title] Long-term outcome of percutaneous coronary intervention for unprotected left main coronary artery disease.
  • OBJECTIVES: The aim of this study is to evaluate the in-hospital, 30 day and long-term outcomes after percutaneous coronary intervention for unprotected left main coronary artery disease.
  • BACKGROUNDS: Left main coronary artery (LMCA) diseases stenosis is a strong indication for coronary artery bypass grafting (CABG).
  • With improved device technology, percutaneous coronary intervention (PCI) with drug-eluting stent (DES) stents had been recently advocated as an alternative procedure for the unprotected LMCA disease.
  • METHODS: Between January 2003 and February 2007, all unprotected LMCA PCI procedures were retrospectively collected.
  • RESULTS: Fifty five consecutive patients with >50% diameter stenosis of LMCA undergoing PCI were analyzed.
  • CONCLUSIONS: Our results showed that PCI with stenting was an acceptable treatment option for patients with LMCA stenosis.
  • Involvement of the LMCA bifurcation remains a predictor for unfavorable outcome.
  • [MeSH-major] Angioplasty, Balloon, Coronary / mortality. Coronary Artery Disease / mortality. Coronary Artery Disease / therapy. Drug-Eluting Stents / statistics & numerical data

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  • [Copyright] Copyright 2008 Elsevier Ireland Ltd. All rights reserved.
  • [CommentIn] Int J Cardiol. 2010 Sep 24;144(1):90-1 [19157586.001]
  • (PMID = 18804295.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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35. Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, Maruhashi T, Kagawa E, Dai K, Matsushita J, Ikenaga H: Electrocardiographic prediction of short-term prognosis in patients with acute myocardial infarction associated with the left main coronary artery. J Electrocardiol; 2009 Mar-Apr;42(2):106-10
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  • [Title] Electrocardiographic prediction of short-term prognosis in patients with acute myocardial infarction associated with the left main coronary artery.
  • PURPOSE: The purpose of this study was to assess the usefulness of electrocardiogram on admission to predict short-term prognosis in patients with acute myocardial infarction (AMI) associated with left main coronary artery (LMCA).
  • METHODS: Electrocardiogram was obtained on admission in 41 patients with AMI associated with LMCA who underwent reperfusion therapy.
  • Nonsurvivors had ST-segment elevation in both leads aVR and aVL (54% vs 18%, P < .05), left anterior fascicular block (83% vs 41%, P < .05), and right bundle-branch block (54% vs 18%, P < .05) more frequently, and ST-segment depression in lead V(5) (17% vs 59%, P < .05) less frequently than survivors among patients with AMI associated with LMCA.
  • CONCLUSIONS: Our data suggested that electrocardiogram on admission might be useful to predict short-term prognosis in patients with AMI associated with LMCA.
  • [MeSH-major] Coronary Artery Disease / diagnosis. Coronary Artery Disease / mortality. Electrocardiography / methods. Myocardial Infarction / diagnosis. Myocardial Infarction / mortality. Outcome Assessment (Health Care) / methods

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  • (PMID = 19084235.001).
  • [ISSN] 1532-8430
  • [Journal-full-title] Journal of electrocardiology
  • [ISO-abbreviation] J Electrocardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Barragan P, Fajadet J, Sheiban I, Serruys P, Colombo A, Seabra-Gomes R, Goy JJ, Cook S, Rubino P, Lefèvre T: Elective implantation of sirolimus-eluting stents for bifurcated and non-bifurcated unprotected left main coronary artery lesions: clinical outcomes at one year. EuroIntervention; 2008 Aug;4(2):262-70
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  • [Title] Elective implantation of sirolimus-eluting stents for bifurcated and non-bifurcated unprotected left main coronary artery lesions: clinical outcomes at one year.
  • AIMS: Recent studies of drug-eluting stents for unprotected left main coronary artery (LMCA) disease have been encouraging.
  • METHODS AND RESULTS: This retrospective study included 228 consecutive patients (mean age = 68 +/- 11 years, 80.6% men, 26.3% diabetics) who underwent implantation of SES for de novo LMCA stenoses.
  • The main objective of this study was to measure the rate of major adverse cardiac events (MACE), including death, myocardial infarction and target lesion revascularisation (TLR) at 12 months.
  • CONCLUSIONS: SES implants in high-risk patients with LMCA stenoses were associated with a low 1-year MACE rate.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy. Immunosuppressive Agents / administration & dosage. Sirolimus / administration & dosage

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  • (PMID = 19110793.001).
  • [ISSN] 1774-024X
  • [Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • [ISO-abbreviation] EuroIntervention
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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37. Qiu JY, Zhang Y, Lu DP, Lai YY, He Q, Shi Y: [Clinical and cytogenetical study on subacute myeloid leukemia in myelodysplastic syndromes]. Zhonghua Nei Ke Za Zhi; 2005 Jun;44(6):407-10
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  • [Title] [Clinical and cytogenetical study on subacute myeloid leukemia in myelodysplastic syndromes].
  • OBJECTIVE: To discuss from the clinical and cytogenetic aspect that part of patients now diagnosed as myelodysplastic syndromes (MDS) could be diagnosed early as leukemia and be classified as subacute myeloid leukemia (Sub-AML).
  • Among them 42 had +8 chromosome aberration, 16 had -7/7q-, and 55 had normal karyotypes and more than 0.10 blast cells in the bone marrow.
  • Short term culture and G-banding techniques and in some specimens fluorescence in situ hybridization (FISH) method were used to do chromosome analysis.
  • RESULTS: Among the detected chromosome aberrations, +8 was the most frequent (42.8%) and then -7/7q-(15.0%); 42 patients with +8 had median blast cell count of 0.08, within a median of 18 months follow-up period 40.0% of the patients evolved to frank leukemia (FL) and the median overall survival was 20 months.
  • CONCLUSIONS: Both the +8 and -7/7q- groups have malignant leukemic cell clone, and run a subacute and progressive clinical course; it is suggested they might be classified into Sub-AML.
  • [MeSH-major] Leukemia, Myeloid, Acute / genetics. Myelodysplastic Syndromes / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chromosome Aberrations. Cytogenetic Analysis. Female. Follow-Up Studies. Humans. Male. Middle Aged


38. Giannoglou GD, Soulis JV, Farmakis TM, Giannakoulas GA, Parcharidis GE, Louridas GE: Wall pressure gradient in normal left coronary artery tree. Med Eng Phys; 2005 Jul;27(6):455-64
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  • [Title] Wall pressure gradient in normal left coronary artery tree.
  • The three-dimensional wall pressure gradient (WPG) of the normal human left coronary artery (LCA) tree is quantitatively analysed.
  • The LCA tree includes the left main coronary artery (LMCA), the left anterior descending (LAD), the left circumflex artery (LCxA) and their major branches.
  • [MeSH-minor] Animals. Computer Simulation. Coronary Artery Disease / physiopathology. Elasticity. Humans. Pressure. Reference Values. Stress, Mechanical

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  • (PMID = 15990062.001).
  • [ISSN] 1350-4533
  • [Journal-full-title] Medical engineering & physics
  • [ISO-abbreviation] Med Eng Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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39. Kim HS, Kim YH, Lee SW, Park DW, Lee CW, Hong MK, Kim JJ, Park SW, Park SJ: Safety and effectiveness of sirolimus-eluting stent implantation for in-stent restenosis of the unprotected left main coronary artery. Int J Cardiol; 2008 Feb 20;124(1):118-20
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  • [Title] Safety and effectiveness of sirolimus-eluting stent implantation for in-stent restenosis of the unprotected left main coronary artery.
  • The present study examined the alternative treatment of sirolimus-eluting stent (SES) implantation for in-stent restenosis (ISR) of the unprotected left main coronary artery (LMCA).
  • Twelve patients underwent SES deployment for bare-metal ISR in the LMCA.
  • ISR were 24+/-11 mm in length and located at the ostial (n=1) and distal (n=11) portion of LMCA.
  • Bifurcation lesions were treated with one of three techniques: the stent crossing the left circumflex artery (n=7), kissing stenting (n=2) or the Crush technique (n=2).
  • There were no cases of significant narrowing in the left circumflex artery after the procedure.
  • The present study suggests that SES implantation may be a feasible therapeutic option for treating ISR in unprotected LMCA.

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  • (PMID = 17383034.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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40. Murasato Y, Horiuchi M, Otsuji Y: Three-dimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography. Catheter Cardiovasc Interv; 2007 Aug 1;70(2):211-20
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  • [Title] Three-dimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography.
  • BACKGROUND: Various double-stent techniques using drug-eluting stents have been proposed to treat the left main coronary artery (LMCA) bifurcation.
  • However, use of these techniques is frequently associated with focal restenosis at the ostium of the left circumflex coronary artery (LCX).
  • OBJECTIVES: To examine the results of double-stent techniques, using a silicon model of the LMCA bifurcation and three-dimensional (3D) reconstruction images created with micro-focus X-ray computed tomography (MFCT).
  • METHODS: Crush, kissing, and modified T stentings were performed with bare metal stents in a LMCA bifurcation model.
  • The stents were then inspected using MFCT at a minimal resolution of 0.06 mm.
  • RESULTS: Gaps in stent apposition to the vessel were observed at the site of stent overlap in the distal LMCA with all stenting techniques.
  • In crush stenting, when the left anterior descending artery stent overlapped the LCX stent, the latter was crushed on the myocardial side of the vessel, and a gap was observed on the nonmyocardial side, at the LCX ostium.
  • CONCLUSIONS: Close apposition of the stent to the vessel at the ostium of the LCX is difficult to achieve at the LMCA bifurcation, regardless of which double-stent technique is employed, due to the site's wide bifurcation angle and complex 3D structure.
  • [MeSH-major] Blood Vessel Prosthesis. Blood Vessel Prosthesis Implantation / instrumentation. Coronary Angiography / methods. Coronary Artery Disease / radiography. Imaging, Three-Dimensional. Radiographic Image Interpretation, Computer-Assisted. Stents. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17421017.001).
  • [ISSN] 1522-1946
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metals
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41. Murati A, Arnoulet C, Lafage-Pochitaloff M, Adélaide J, Derré M, Slama B, Delaval B, Popovici C, Vey N, Xerri L, Mozziconacci MJ, Boulat O, Sainty D, Birnbaum D, Chaffanet M: Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. Int J Oncol; 2005 Jun;26(6):1485-92
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  • [Title] Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion.
  • The case of a patient presenting with a myeloproliferative disorder (MPD) characterized by a t(8;22) (p12;q11) translocation was investigated.
  • The rearrangement resulted in the production of BCR-FGFR1 and FGFR1-BCR chimeric transcripts after in-frame fusions of BCR exon 4 with FGFR1 exon 9 and FGFR1 exon 8 with BCR exon 5, respectively.
  • The four previously reported patients with such translocation presented with an atypical chronic myeloid leukemia (CML) without Philadelphia chromosome.
  • The BCR-FGFR1 gene fusion was detected by dual-color fluorescence in situ hybridization in both CD19- and CD19+ populations.
  • In contrast to the other FGFR1-MPDs that show myeloid and T cell proliferation, we propose that this t(8;22) MPD is a myeloid and B cell disease, and potentially a novel type of hematological disease.
  • [MeSH-minor] Aged. Chromosomes, Human, Pair 22. Humans. Immunophenotyping. Male. Proto-Oncogene Proteins c-bcr. Receptor, Fibroblast Growth Factor, Type 1

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  • (PMID = 15870860.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Receptors, Fibroblast Growth Factor; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.11.1 / BCR protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr
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42. Soleimani A, Abbasi A, Kazzazi EH, Hosseini K, Salirifar M, Darabian S, Sadeghian S, Sheikhfathol-Lahi M: Prevalence of left main coronary artery disease among patients with ischemic heart disease: insights from the Tehran Angiography Registry. Minerva Cardioangiol; 2009 Apr;57(2):175-83
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  • [Title] Prevalence of left main coronary artery disease among patients with ischemic heart disease: insights from the Tehran Angiography Registry.
  • AIM: This study was designed to investigate the prevalence of left main coronary artery (LMCA) significant stenosis among patients with stable angina (SA) or acute coronary syndromes (ACSs) and to assess the influence of demographic and clinical profiles on these findings.
  • The patients' characteristics were compared in subgroups with and without LMCA disease.
  • RESULTS: Significant and minimal LMCA stenoses were found in 659 (3.6%) and 1157 (6.4%) patients, respectively.
  • An unprotected LMCA disease was estimated in 609 (3.4%) subjects.
  • A cumulative Logit Model analysis revealed the male gender (odds ratio [OR]=1.480, 95% confidence interval [CI]=1.287 to 1.703; P<0.001), diabetes mellitus (OR=1.158, 95% CI=1.029 to 1.303; P=0.015), dyslipidemia (OR=1.125, 95% CI=1.001 to 1.265; P=0.048), and aging (OR=1.028, 95% CI=1.022 to 1.034; P<0.001) as the independent predictors of LMCA stenosis with coexistent diseases in the rest of the coronary arteries.
  • In the patients with normal or minimal stenoses of the other coronary arteries, cigarette smoking (OR=3.749, 95% CI=1.698 to 8.070) was found to be the independent risk factor of isolated LMCA disease.
  • Luminal stenosis >50% in the right coronary artery, the left circumflex artery, and the left anterior descending artery was significantly more frequent in association with LMCA disease.
  • CONCLUSIONS: The patients with LMCA disease were more likely to be male, older, and have diabetes mellitus or dyslipidemia, whereas cigarette smoking was found as an independent predictor of isolated LMCA.
  • There was a strong correlation between the severity of LMCA stenosis and coexistent diseases in the rest of the coronary arteries.
  • [MeSH-major] Coronary Artery Disease / epidemiology. Medical Records / statistics & numerical data. Myocardial Ischemia / complications

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  • (PMID = 19274028.001).
  • [ISSN] 0026-4725
  • [Journal-full-title] Minerva cardioangiologica
  • [ISO-abbreviation] Minerva Cardioangiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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43. Han Y, Wang S, Jing Q, Li Y, Liu H, Ma Y, Wang Z, Wang D, Luan B, Wang G, Chen T: Comparison of long-term efficacy of the paclitaxel-eluting stent versus the bare-metal stent for treatment of unprotected left main coronary artery disease. Am J Cardiol; 2009 Jan 15;103(2):194-8
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  • [Title] Comparison of long-term efficacy of the paclitaxel-eluting stent versus the bare-metal stent for treatment of unprotected left main coronary artery disease.
  • The use of paclitaxel-eluting stents (PES) for the treatment of unprotected left main coronary artery (LMCA) disease is controversial.
  • Between January 2003 and December 2006, a total of 287 patients undergoing percutaneous coronary intervention for LMCA lesions were consecutively registered.
  • PES recipients had distal left main bifurcation lesions more frequently compared with BMS recipients (72 vs 42%, p<0.01).
  • In conclusion, PES implantation provides a safe, effective therapy for unprotected LMCA disease and decreases the risk of major adverse cardiac events compared with BMS at a mean follow-up of 35 months.
  • [MeSH-major] Coronary Artery Disease / therapy. Drug-Eluting Stents. Paclitaxel / administration & dosage. Stents. Tubulin Modulators / administration & dosage

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  • (PMID = 19121435.001).
  • [ISSN] 1879-1913
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel
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44. Wong D, Golding F, Hess L, Caldarone CA, Van Arsdell G, Manlhiot C, McCrindle BW, Miner SE, Nield LE: Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation. Am Heart J; 2008 Sep;156(3):466-72
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  • [Title] Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation.
  • BACKGROUND: Arterial switch operation is standard repair for complete transposition of the great arteries (TGA).
  • Coronary artery abnormalities are the most common cause of morbidity and mortality in the acute postoperative phase.
  • This study was designed to determine whether coronary artery pulse Doppler flow patterns obtained by transesophageal echocardiography during the arterial switch operation are correlated with acute postoperative outcomes.
  • Intraoperative coronary artery pulse Doppler flow patterns were analyzed by 2 blinded investigators.
  • Associations of coronary artery pulse Doppler flow patterns with clinical outcomes were sought using multivariable linear and logistic regression analysis.
  • The most common coronary artery pulse Doppler flow pattern consisted of a late systolic peak followed by low-velocity flow throughout diastole.
  • A left main coronary artery (LMCA) velocity time integral >0.14 (P = .01) and an LMCA peak systolic velocity >0.6 cm/s (P = .05) were associated with need for surgical revision.
  • CONCLUSION: Abnormalities in LMCA flow were associated with the need for surgical revision in patients with TGA undergoing the arterial switch operation.
  • Normal coronary artery pulse Doppler flow patterns after the arterial switch operation consisted of a late systolic peak followed by low-velocity flow throughout diastole.

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  • (PMID = 18760127.001).
  • [ISSN] 1097-6744
  • [Journal-full-title] American heart journal
  • [ISO-abbreviation] Am. Heart J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Lee BK, Hong MK, Lee CW, Choi BR, Kim MJ, Park KH, Kim YH, Han KH, Kim JJ, Park SW, Park SJ: Five-year outcomes after stenting of unprotected left main coronary artery stenosis in patients with normal left ventricular function. Int J Cardiol; 2007 Feb 7;115(2):208-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Five-year outcomes after stenting of unprotected left main coronary artery stenosis in patients with normal left ventricular function.
  • BACKGROUND: We analyzed the long-term (5-year) outcome of patients treated with stenting for unprotected left main coronary artery (LMCA) stenosis.
  • METHODS: Between January 1995 and September 2001, 187 consecutive patients with unprotected LMCA stenosis and normal left ventricular function underwent elective stenting.
  • At 1, 3 and 5 years, the cumulative probabilities for freedom from MACE were 79.9+/-1.8%, 77.5+/-2.5% and 77.5+/-2.5%, respectively.
  • CONCLUSION: The initial favorable outcomes of patients with normal left ventricular function after stenting of unprotected LMCA stenosis were sustained for up to 5 years.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Stenosis / therapy. Stents. Ventricular Function, Left

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  • (PMID = 16904209.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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46. Noestelthaller A, Probst A, König HE: Branching patterns of the left main coronary artery in the dog demonstrated by the use of corrosion casting technique. Anat Histol Embryol; 2007 Feb;36(1):33-7
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  • [Title] Branching patterns of the left main coronary artery in the dog demonstrated by the use of corrosion casting technique.
  • As many investigators use dogs as experimental models in catheterization-, ligation-, and collateral flow studies, knowledge and awareness of the canine left coronary artery anatomical variation is vital for differentiation between canine and human coronary arterial patterns and canine and human coronary congenital anomalies with or without circulatory importance.
  • The present study was performed to examine and review the various principal subdivisions of the canine left main coronary artery (LMCA) in vascular casts of 20 hearts obtained from cadavers of clinically normal dogs of various ages, breeds and of either sex.
  • A corrosion casting technique using an acrylic resin called Tensol Cement No. 70 and a lower-viscosity acrylic resin called Mercox were used to produce a three-dimensional model of the canine coronary arteries.
  • In our study, all dog hearts were left preponderant and the patterns of the principal subdivisions of the LMCA were grouped into three types: Type 1 occurred in seven of the 20 dogs (35%), Type 2 in 12 of 20 dogs (60%) and Type 3 in one instance (5%).
  • A comparison between the canine divisional patterns of the LMCA in the vascular casts and those reported in the literature showed major agreement.

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  • (PMID = 17266665.001).
  • [ISSN] 0340-2096
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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47. Bitigen A, Karavelioglu Y, Kaynak E, Yilmaz MB: A case of myocardial infarction due to acute left main coronary artery occlusion presenting with peculiar electrocardiographic changes. Int J Cardiovasc Imaging; 2006 Jun-Aug;22(3-4):343-7
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  • [Title] A case of myocardial infarction due to acute left main coronary artery occlusion presenting with peculiar electrocardiographic changes.
  • Myocardial infarction (MI) due to acute obstruction of the left main coronary artery (LMCA) occlusion is a medical emergency, requiring early and prompt diagnosis and revascularization, and unless it is treated, it will frequently result in cardiogenic shock, which has a high fatality rate.
  • ECG is the easiest diagnostic method in the early diagnosis of the acute coronary syndromes and in deciding on the early invasive intervention in the high risk group.
  • At the time of the urgent coronary angiography, it was noticed that the LMCA was totally occluded.
  • This case has been presented in order to emphasize that peculiar changes might bring about devastating consequences as in our rare case, showing acute left main coronary artery occlusion, and ST segment elevation only in the AVR on the 12-lead ECG along with upward deflection of ST segment vector might be critical for accurate diagnosis.

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  • [Cites] J Am Coll Cardiol. 2001 Nov 1;38(5):1348-54 [11691506.001]
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  • (PMID = 16518669.001).
  • [ISSN] 1569-5794
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Parodi G, Maehara A, Giuliani G, Kubo T, Mintz GS, Migliorini A, Valenti R, Carrabba N, Antoniucci D: Optical coherence tomography in unprotected left main coronary artery stenting. EuroIntervention; 2010 May;6(1):94-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optical coherence tomography in unprotected left main coronary artery stenting.
  • AIMS: Delayed or incomplete stent endothelisation and stent malapposition may predispose to DES thrombosis that can be a catastrophic event in the left main coronary artery (LMCA).
  • OCT can accurately identify stent struts and arterial tissue, but is limited by the need of vessel blood clearance and penetration; also no data exist on its use in LMCA.
  • We sought to verify whether optical coherence tomography (OCT) can accurately assess arterial wall response after drug eluting stent (DES) implantation in the LMCA.
  • METHODS AND RESULTS: OCT images were obtained in 15 patients (mean age 70.7 + or - 8.0 years) six months after LMCA DES implantation.
  • Acquisitions were performed without proximal balloon occlusion during isoosmolar contrast injection through a 6 Fr guiding catheter without side holes at a speed of 2-3 mL/sec.
  • In five patients OCT detected abnormal intraluminal tissue, and in two cases this finding was related to uncovered struts.
  • CONCLUSIONS: OCT assessment of vascular response after LMCA DES implantation is safe and feasible.
  • Further development of OCT imaging technology will be necessary for complete evaluation of LMCA stents.
  • [MeSH-major] Angioplasty, Balloon, Coronary / instrumentation. Coronary Artery Disease / therapy. Coronary Vessels / pathology. Drug-Eluting Stents. Tomography, Optical Coherence

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  • (PMID = 20542803.001).
  • [ISSN] 1969-6213
  • [Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • [ISO-abbreviation] EuroIntervention
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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49. Crnovcić I, Süssmuth R, Keller U: Aromatic C-methyltransferases with antipodal stereoselectivity for structurally diverse phenolic amino acids catalyze the methylation step in the biosynthesis of the actinomycin chromophore. Biochemistry; 2010 Nov 16;49(45):9698-705
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  • The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus harbors two paralogous genes, acmI and acmL, encoding methyltransferases.
  • AcmI and AcmL methylate also hydroxyphenyl-amino propanoic acids such as p-tyrosine, m-tyrosine, or 3,4-dihydroxy-l-phenylalanine (DOPA) but at a lower rate than 3-HK.
  • AcmI and AcmL show sequence similarity to various C- and O-methyltransferases from bacteria.
  • Remarkably, computational remodelling of AcmI and AcmL structures revealed significant similarity with the 3-D structures of type 1 O-methyltransferases from plants such as caffeic acid O-methyltransferase (COMT) and other phenylpropanoid methyltransferases.

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  • (PMID = 20945860.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / DNA Primers; 0 / DNA, Bacterial; 0 / Phenols; 1CC1JFE158 / Dactinomycin; 343-65-7 / Kynurenine; 42HK56048U / Tyrosine; EC 2.1.1.- / Methyltransferases
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50. Suzuki T, Asai T, Matsubayashi K, Kambara A, Hiramatsu N, Kinoshita T, Nishimura O: Left main coronary artery disease does not affect the outcome of off-pump coronary artery bypass grafting. Ann Thorac Surg; 2010 Nov;90(5):1501-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Left main coronary artery disease does not affect the outcome of off-pump coronary artery bypass grafting.
  • BACKGROUND: Left main coronary artery (LMCA) stenosis (≥50%) has historically been recognized as a risk factor among patients undergoing coronary artery bypass grafting.
  • METHODS: From January 2002 to December 2008, a total of 665 patients, 268 of whom had significant LMCA disease, underwent isolated off-pump coronary artery bypass surgery at Shiga Medical University Hospital.
  • We compared the clinical results in the 237 patients with LMCA stenosis (LMCA group) with those in the propensity score-matched 237 patients without LMCA stenosis (non-LMCA group).
  • We performed off-pump surgery in all coronary artery bypass grafting cases with no exclusion criteria.
  • Two patients in the LMCA group (2 of 237; 0.8%) and four in the non-LMCA group (4 of 237; 1.7%) died within 30 days after surgery.
  • The rates of six-year freedom from all cause death were 87.3% and 60.7% in the LMCA group and non-LMCA group, respectively (p = 0.17), and the corresponding rates for the combined endpoint of cardiac death, myocardial infarction, angina pectoris, repeat coronary intervention, and heart failure were 80.4% and 70.4% (p = 0.98).
  • Multivariate Cox regression analysis revealed chronic renal failure as a statistically significant predictor for late cardiac event.
  • CONCLUSIONS: Off-pump coronary artery bypass grafting is feasible and safe in patients with critical LMCA stenosis and LMCA disease is not recognized as a risk factor after off-pump coronary artery bypass grafting in either the short or the long term.
  • [MeSH-major] Coronary Artery Bypass, Off-Pump / adverse effects. Coronary Stenosis / complications
  • [MeSH-minor] Aged. Female. Humans. Kidney Failure, Chronic / etiology. Male. Middle Aged. Proportional Hazards Models. Treatment Outcome

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2010 Nov;90(5):1506 [20971249.001]
  • (PMID = 20971248.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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51. Kim U, Park JS, Seol SH, Yang TH, Kim SM, Kim DK, Kim DI, Kim DS, Lee WJ, Lee SH, Hong GR, Shin DG, Kim YJ, Shim BS, Cho YK, Kim HS, Nam CW, Hur SH, Kim KB, Kim YN: Two-year outcomes of the sirolimus-eluting stent according to unprotected left main lesion. Clin Cardiol; 2009 Jun;32(6):332-6
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  • [Title] Two-year outcomes of the sirolimus-eluting stent according to unprotected left main lesion.
  • BACKGROUND: The data of long-term outcomes of sirolimus-eluting stent (SES) according to lesion location of unprotected left main coronary artery (LMCA) is scarce.
  • HYPOTHESIS: The purpose of this study was to evaluate the long-term outcomes after implantation of the SES in LMCA.
  • METHODS: A total of 84 patients (51 males) who had undergone SES implantation for the treatment of native LMCA stenosis were enrolled.
  • Although angiographic success and in-hospital MACE rates were similar in both groups with 1 cardiac death due to acute stent thrombosis in group 2, at 2-year follow-up, the MACE rate was significantly higher in group 2 than in group 1 at 2 years (22.2% vs 2.6%, respectively, P = 0.008).
  • CONCLUSIONS: Interventional treatment using SES in left main lesions showed favorable short-term and long-term outcomes in selected patients with lesion location being an important determinant of clinical and angiographic outcomes.

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  • [Copyright] 2009 Wiley Periodicals, Inc.
  • (PMID = 19569064.001).
  • [ISSN] 1932-8737
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cardiovascular Agents; W36ZG6FT64 / Sirolimus
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52. Kim YH, Dangas GD, Solinas E, Aoki J, Parise H, Kimura M, Franklin-Bond T, Dasgupta NK, Kirtane AJ, Moussa I, Lansky AJ, Collins M, Stone GW, Leon MB, Moses JW, Mehran R: Effectiveness of drug-eluting stent implantation for patients with unprotected left main coronary artery stenosis. Am J Cardiol; 2008 Mar 15;101(6):801-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of drug-eluting stent implantation for patients with unprotected left main coronary artery stenosis.
  • This study was aimed to evaluate outcomes of patients with unprotected left main coronary artery (LMCA) stenosis who were treated with drug-eluting stents.
  • Sixty-three consecutive patients with unprotected LMCA stenosis were treated with sirolimus-eluting stents in 52 (83%) patients and paclitaxel-eluting stents in 11 (17%) patients, in whom percutaneous intervention was considered the sole alternative because of high surgical risk and/or patient preference.
  • Involvement of the distal LMCA was observed in 46 (73%) patients.
  • In conclusion, drug-eluting stent placement for unprotected LMCA stenosis may be a feasible therapeutic alternative in patients at high surgical risk.

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  • (PMID = 18328844.001).
  • [ISSN] 0002-9149
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible; 0 / Immunosuppressive Agents; 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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53. Namboodiri N, Ajitkumar V, Tharakan J: A rare type of dual left anterior descending artery distribution demonstrated by multislice cardiac computerized tomography in a patient with anterior wall infarction. J Invasive Cardiol; 2008 Jul;20(7):367-9
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  • [Title] A rare type of dual left anterior descending artery distribution demonstrated by multislice cardiac computerized tomography in a patient with anterior wall infarction.
  • Dual left anterior descending coronary artery (LAD) distribution with either of the vessels originating from the left main coronary artery (LMCA) and the right aortic sinus of Valsalva is an extremely rare coronary artery anomaly.
  • Here we discuss a 45-year-old male who presented with non-ST-elevation anterior wall myocardial infarction due to near-total occlusion of the LAD immediately after its origin from the LMCA.

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  • (PMID = 18599898.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Kim YH, Park SW, Hong MK, Park DW, Park KM, Lee BK, Song JM, Han KH, Lee CW, Kang DH, Song JK, Kim JJ, Park SJ: Comparison of simple and complex stenting techniques in the treatment of unprotected left main coronary artery bifurcation stenosis. Am J Cardiol; 2006 Jun 1;97(11):1597-601
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  • [Title] Comparison of simple and complex stenting techniques in the treatment of unprotected left main coronary artery bifurcation stenosis.
  • We assessed the safety and feasibility of various stenting techniques using the sirolimus-eluting stent (SES) in the treatment of unprotected left main coronary artery (LMCA) bifurcation stenoses.
  • One hundred sixteen patients with unprotected LMCA bifurcation stenoses underwent SES implantation.
  • A simple stenting technique (simple group, n = 67) across the left circumflex artery (LCx) and a complex technique (complex group) comprising "kissing" stenting (n = 24) or a "crush" (n = 25) technique were used.
  • In conclusion, SES implantation for unprotected LMCA bifurcation stenoses appears to be safe and effective.

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  • (PMID = 16728221.001).
  • [ISSN] 0002-9149
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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55. Tsupryk A, Gorbovitski M, Kabotyanski EA, Gorfinkel V: Novel design of multicapillary arrays for high-throughput DNA sequencing. Electrophoresis; 2006 Jul;27(14):2869-79
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  • A novel approach to design and optimize linear multicapillary arrays (LMCAs) for high-throughput DNA sequencing is proposed.
  • Theoretical and experimental studies showed that in conjunction with a dual-side laser illumination scheme, the proposed LMCA design allows a simultaneous uniform irradiation of as many as 550 working capillaries.

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  • (PMID = 16800025.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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56. Lee RJ, Shih KN, Lee SH, Shyu KG, Chiu CZ, Lin SC, Hung HF, Liou JY, Cheng JJ, Kuan P: Predictors of long-term outcomes in patients after elective stent implantation for unprotected left main coronary artery disease. Heart Vessels; 2007 Mar;22(2):99-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictors of long-term outcomes in patients after elective stent implantation for unprotected left main coronary artery disease.
  • The purpose of this study was to investigate the predictor of long-term outcomes in patients after stent implantation for unprotected left main coronary artery (LMCA) disease.
  • Coronary stenting has recently been advocated as an alternative procedure for LMCA disease.
  • Information on the predictors of long-term outcomes in patients after stent implantation for unprotected LMCA disease is not clear.
  • Seventy six patients (51 men and 25 women, age 68 +/- 10 years) with medically refractory angina received coronary stenting for unprotected LMCA disease.
  • During a follow-up period of 40 +/- 26 months, 7 patients (9%) died because of cardiovascular disease in 5 (7%) and noncardiovascular disease in 2 (3%).
  • In the other 69 patients, 19 patients (25%) needed repeated percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG).
  • A history of cerebral vascular attack (CVA) (P = 0.005), anemia (P = 0.03) and lower left ventricular ejection fraction (LVEF) (P = 0.008) were related to the cardiovascular mortality.
  • Female sex and young age could predict the repeated PCI and/or CABG in patients after stent implantation for unprotected LMCA disease.
  • [MeSH-major] Coronary Artery Disease / therapy. Stents
  • [MeSH-minor] Age Factors. Aged. Analysis of Variance. Angioplasty, Balloon, Coronary. Coronary Artery Bypass. Coronary Restenosis / therapy. Female. Humans. Male. Middle Aged. Prognosis. Retreatment. Risk Factors. Sex Factors. Stroke Volume. Treatment Outcome

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  • (PMID = 17390204.001).
  • [ISSN] 0910-8327
  • [Journal-full-title] Heart and vessels
  • [ISO-abbreviation] Heart Vessels
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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57. Carrié D, Lhermusier T, Hmem M, Maupas E, Elbaz M, Puel J: Clinical and angiographic outcome of paclitaxel-eluting stent implantation for unprotected left main coronary artery bifurcation narrowing. EuroIntervention; 2006 Feb;1(4):396-402
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and angiographic outcome of paclitaxel-eluting stent implantation for unprotected left main coronary artery bifurcation narrowing.
  • AIMS: This study was designed to compare the clinical and angiographic outcomes of paclitaxel-eluting stent (PES) and bare metal stent (BMS) implantation for unprotected left main coronary artery (LMCA) bifurcation narrowing.
  • METHODS AND RESULTS: From November 2003 to December 2004, the technique of kissing balloon followed by T provisional stenting was applied for distal left main coronary lesion in 49 consecutive patients with PES stents.
  • CONCLUSION: Paclitaxel-eluting stent implantation for unprotected LMCA bifurcation narrowing appears safe with regard to acute and midterm complications and is more effective in preventing restenosis compared to BMS implantation.

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  • (PMID = 19755213.001).
  • [ISSN] 1774-024X
  • [Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • [ISO-abbreviation] EuroIntervention
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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58. Olivieri L, Arling B, Friberg M, Sable C: Coronary artery Z score regression equations and calculators derived from a large heterogeneous population of children undergoing echocardiography. J Am Soc Echocardiogr; 2009 Feb;22(2):159-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coronary artery Z score regression equations and calculators derived from a large heterogeneous population of children undergoing echocardiography.
  • BACKGROUND: Clinical decision making in Kawasaki disease relies on measurements of the coronary arteries obtained by 2-dimensional echocardiography.
  • Z scores relating measured values to independent variables are invaluable in ensuring the accurate and consistent treatment of patients with Kawasaki disease.
  • METHODS: The right coronary artery (RCA), left main coronary artery (LMCA), and left anterior descending (LAD) coronary artery were measured in 432 normal digital echocardiograms from a heterogeneous population of normal subjects aged 0 to 20 years.
  • RESULTS: Using the model ln(measurement) = beta(1) + beta(2) x ln(BSA), the adjusted R(2) values were 0.638, 0.702, and 0.708 for the RCA, LMCA, and LAD coronary artery models, respectively, with mean square error < 0.0402.
  • CONCLUSION: The calculation of accurate Z scores for coronary artery measurements in children can be accomplished using the Z-score calculator.

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  • (PMID = 19084373.001).
  • [ISSN] 1097-6795
  • [Journal-full-title] Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
  • [ISO-abbreviation] J Am Soc Echocardiogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Park DW, Seung KB, Kim YH, Lee JY, Kim WJ, Kang SJ, Lee SW, Lee CW, Park SW, Yun SC, Gwon HC, Jeong MH, Jang YS, Kim HS, Kim PJ, Seong IW, Park HS, Ahn T, Chae IH, Tahk SJ, Chung WS, Park SJ: Long-term safety and efficacy of stenting versus coronary artery bypass grafting for unprotected left main coronary artery disease: 5-year results from the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) registry. J Am Coll Cardiol; 2010 Jul 6;56(2):117-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term safety and efficacy of stenting versus coronary artery bypass grafting for unprotected left main coronary artery disease: 5-year results from the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) registry.
  • OBJECTIVES: We performed the long-term follow-up of a large cohort of patients in a multicenter study receiving left main coronary artery (LMCA) revascularization.
  • BACKGROUND: Limited information is available on long-term outcomes for patients with unprotected LMCA disease who underwent coronary stent procedure or coronary artery bypass grafting (CABG).
  • METHODS: We evaluated 2,240 patients with unprotected LMCA disease who received coronary stents (n = 1,102; 318 with bare-metal stents and 784 with drug-eluting stents) or underwent CABG (n = 1,138) between 2000 and 2006 and for whom complete follow-up data were available for at least 3 to 9 years (median 5.2 years).
  • CONCLUSIONS: During 5-year follow-up, stenting showed similar rates of mortality and of the composite of death, Q-wave MI, or stroke but higher rates of TVR as compared with CABG for patients with unprotected LMCA disease.
  • [MeSH-major] Coronary Disease / therapy. Stents
  • [MeSH-minor] Coronary Artery Bypass. Drug-Eluting Stents. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • [Copyright] Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20451344.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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60. Shimizu T, Miyakawa Y, Mitsuhashi T, Kakimoto T, Ikeda Y, Kizaki M, Hagiwara T: [Persistent neutrophilia occurring after pneumonia: a differential diagnosis of neutrophilia based on the WHO classification]. Rinsho Ketsueki; 2005 Jul;46(7):532-5
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  • [Title] [Persistent neutrophilia occurring after pneumonia: a differential diagnosis of neutrophilia based on the WHO classification].
  • Bone marrow examination revealed hypercellularity without excess of blasts and hiatus leukemia, accompanied by mild dysplasia in myeloid cells and megakaryocytes.
  • Major/minor BCR-ABL fusion genes were negative by RT-PCR.
  • As previously reported by several investigators, we often experience difficulties in distinguishing atypical CML from CNL and CMML.
  • [MeSH-major] Leukocytosis / classification. Leukocytosis / diagnosis. Neutrophils. Pneumonia, Bacterial / complications
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. World Health Organization

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  • (PMID = 16440748.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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61. Koşar P, Ergun E, Oztürk C, Koşar U: Anatomic variations and anomalies of the coronary arteries: 64-slice CT angiographic appearance. Diagn Interv Radiol; 2009 Dec;15(4):275-83
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  • [Title] Anatomic variations and anomalies of the coronary arteries: 64-slice CT angiographic appearance.
  • PURPOSE: To retrospectively review the 64-slice computed tomography (CT) appearance of coronary artery anatomic variants and anomalies and determine their incidence in 700 patients.
  • MATERIALS AND METHODS: CT data of 700 patients who underwent 64-slice CT angiography (CTA) because of known or suspected coronary artery disease were retrospectively reviewed by two radiologists experienced in cardiovascular radiology.
  • RESULTS: The coronary artery system was right dominant in 76%, left dominant in 9.1% and co-dominant in 14.8% of the cases.
  • Conus artery with a separate ostium in the right sinus Valsalva was observed in 22%, and in 0.2% two conus arteries originating with separate ostia were visualized.
  • The sinus node artery (SNA) originated from the right coronary artery (RCA) in 79%, from the circumflex artery (Cx) in 20%, and from the left main coronary artery (LMCA) in 0.4%.
  • LMCA was absent in 0.4%.
  • High takeoff of LMCA and RCA were observed in 0.7% and 0.1%, respectively.
  • Anomalous origin of the coronary artery from the opposite sinus was observed in 1% of the cases.
  • CONCLUSION: Complex anatomy of the coronary artery system can accurately be depicted by 64-slice CTA.
  • This modality is useful in detecting coronary artery variants and anomalies and is a valid alternative to conventional coronary angiography in their diagnosis.
  • [MeSH-major] Angiography, Digital Subtraction / methods. Coronary Angiography / methods. Coronary Disease / radiography. Coronary Vessel Anomalies / radiography. Coronary Vessels / anatomy & histology

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  • (PMID = 19957241.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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62. Vlădaia A, Ginghină C, Mereuţă A, Moldovan H: ["Needle-to-scalpel"--the benefit of urgent CABG in significant left main coronary artery stenosis]. Chirurgia (Bucur); 2008 Jul-Aug;103(4):473-7
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  • [Title] ["Needle-to-scalpel"--the benefit of urgent CABG in significant left main coronary artery stenosis].
  • [Transliterated title] "Timpul de la ac la bisturiu": beneficiul intervenţiei chirurgicale prompte in stenoza de trunchi de coronară stâng.
  • Left main coronary artery (LMCA) stenosis is a relatively infrequent but important cause of symptomatic coronary artery disease.
  • The diagnosis of left main coronary artery disease is made by coronary angiography.
  • Coronary artery bypass grafting is the first-line therapy, the standard treatment for LMCA stenosis, which improves the likelihood of survival, while percutaneous coronary intervention (PCI) is emerging as a possible alternative to surgery.
  • We present the case of a patient with history and symptoms of stable angina pectoris, especially associated with exercise, variable threshold, since four years, and who describes a worsening of symptoms in the last month; the angina had become more frequent, more prolonged and occurred at a lower threshold.
  • This investigation showed severe left main coronary artery stenosis and significant lesions in other important vessels (three-vessel disease), in a patient with normal left ventricular function.
  • The recurrence and the intensity of prolonged angina of our patient have necessitated urgent myocardial revascularization surgery with quadruple coronary-artery bypass grafting.
  • CONCLUSIONS: The advantage of coronary artery bypass grafting performed as urgent surgery for the treatment of our patient with left main coronary artery stenosis and concomitant acute coronary syndrome, shortly after coronary angiography, was obvious, significantly improved the clinical outcome, without postoperative ischemic complications.
  • [MeSH-major] Acute Coronary Syndrome / etiology. Coronary Artery Bypass. Coronary Stenosis / diagnosis. Coronary Stenosis / surgery

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  • (PMID = 18780623.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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63. Courtis J, Rodés-Cabau J, Larose E, Potvin JM, Déry JP, Larochellière RD, Côté M, Cousterousse O, Nguyen CM, Proulx G, Rinfret S, Bertrand OF: Usefulness of coronary fractional flow reserve measurements in guiding clinical decisions in intermediate or equivocal left main coronary stenoses. Am J Cardiol; 2009 Apr 1;103(7):943-9
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  • [Title] Usefulness of coronary fractional flow reserve measurements in guiding clinical decisions in intermediate or equivocal left main coronary stenoses.
  • The objectives of this study were to evaluate the usefulness of fractional flow reserve (FFR) measurements to guide the clinical decision in patients with intermediate left main coronary artery (LMCA) stenosis and to determine the predictors of major adverse cardiac events (MACE) -- cardiac death, myocardial infarction, coronary revascularization -- in such cases; 142 consecutive patients with intermediate LMCA stenosis (mean percent diameter stenosis 42 +/- 13%) were included.
  • All patients underwent FFR measurement after intracoronary administration of adenosine at a dose > or =30 microg.
  • At 14 +/- 11 months follow-up, the incidence of MACE related to the LMCA stenosis was 13% in the medical treatment group and 7% in the revascularization group (p = 0.27).
  • In conclusion, FFR measurement is helpful in guiding the decision whether to revascularize patients with intermediate LMCA stenosis.
  • However, patients with diabetes remain at higher risk, and higher doses than previously recommended of intracoronary adenosine might have to be used in the evaluation of LMCA stenosis.
  • [MeSH-minor] Adenosine / administration & dosage. Blood Pressure / physiology. Diagnosis, Differential. Electrocardiography. Female. Humans. Injections, Intra-Arterial. Male. Middle Aged. Myocardial Revascularization / methods. Vasodilator Agents / administration & dosage

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  • (PMID = 19327420.001).
  • [ISSN] 1879-1913
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; K72T3FS567 / Adenosine
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64. Breccia M, Russo E, De Propris MS, Frustaci A, Alimena G: Atypical chronic myeloid leukaemia with CD117-positive blast cells treated with imatinib: A report of two cases. Acta Haematol; 2006;116(3):211-2
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  • [Title] Atypical chronic myeloid leukaemia with CD117-positive blast cells treated with imatinib: A report of two cases.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / therapeutic use. Proto-Oncogene Proteins c-kit / analysis. Pyrimidines / therapeutic use

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  • (PMID = 17016042.001).
  • [ISSN] 0001-5792
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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65. Latsios G, Tsioufis K, Tousoulis D, Kallikazaros I, Stefanadis C: Common origin of both right and left coronary arteries from the right sinus of Valsalva. Int J Cardiol; 2008 Aug 18;128(2):e60-1
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  • [Title] Common origin of both right and left coronary arteries from the right sinus of Valsalva.
  • Anomalous origin of the left main coronary artery (LMCA) from the right sinus of Valsalva (RSOV) represents in about 2 per 10,000 patients undergoing diagnostic cardiac catheterization.
  • We describe the case of a middle-aged woman, suffering from typical angina pectoris, with an anomalous common origin of all coronary arteries from the RSOV.

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  • (PMID = 17692404.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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66. Park SJ, Kim YH: Percutaneous coronary intervention for unprotected left main coronary artery stenosis. World J Cardiol; 2010 Apr 26;2(4):78-88
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  • [Title] Percutaneous coronary intervention for unprotected left main coronary artery stenosis.
  • Hemodynamically significant left main coronary artery stenosis (LMCA) is found in around 4% of diagnostic coronary angiograms and is known as unprotected LMCA stenosis if the left coronary artery and left circumflex artery has no previous patent grafts.
  • Previous randomized studies have demonstrated a significant reduction in mortality when revascularization by coronary artery bypass graft (CABG) surgery was undertaken compared with medical treatment.
  • However, with the advent of drug-eluting stents (DES), the long term outcomes of PCI with DES to treat unprotected LMCA stenoses have been acceptable.
  • Therefore, apart from the current guidelines, PCI for treatment of unprotected LMCA stenosis is often undertaken in individuals who are at a very high risk of CABG or refuse to undergo a sternotomy.
  • Future randomized studies comparing CABG vs PCI using DES for treatment of unprotected LMCA stenosis would be a great advance in clinical knowledge for the adoption of appropriate treatment.

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  • (PMID = 21160702.001).
  • [ISSN] 1949-8462
  • [Journal-full-title] World journal of cardiology
  • [ISO-abbreviation] World J Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998877
  • [Keywords] NOTNLM ; Bypass surgery / Left main / Prognosis / Restenosis / Stent
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67. Chieffo A, Park SJ, Meliga E, Sheiban I, Lee MS, Latib A, Kim YH, Valgimigli M, Sillano D, Magni V, Biondi-Zoccai G, Montorfano M, Airoldi F, Rogacka R, Carlino M, Michev I, Lee CW, Hong MK, Park SW, Moretti C, Bonizzoni E, Sangiorgi GM, Tobis J, Serruys PW, Colombo A: Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry. Eur Heart J; 2008 Sep;29(17):2108-15
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  • [Title] Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry.
  • AIMS: To evaluate the occurrence of late and very late stent thrombosis (ST) following elective drug-eluting stent (DES) implantation in unprotected left main coronary artery (LMCA) stenosis in a large multicentre registry.
  • METHODS AND RESULTS: All 731 consecutive patients who had sirolimus- or paclitaxel-eluting stent electively implanted in de novo lesions on unprotected LMCA in five centres were included.
  • Four (0.5%) patients had a definite ST: three early (two acute and one subacute) and one late ST, no cases of very late definite ST were recorded.
  • CONCLUSION: Elective treatment of LMCA stenosis with DES appears safe with a 0.9% incidence of definite and probable ST at 29.5 ± 13.7 months.

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  • [CommentIn] Eur Heart J. 2008 Sep;29(17):2064-6 [18664463.001]
  • (PMID = 18565967.001).
  • [ISSN] 1522-9645
  • [Journal-full-title] European heart journal
  • [ISO-abbreviation] Eur. Heart J.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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68. Seung KB, Kim YH, Park DW, Lee BK, Lee CW, Hong MK, Kim PJ, Chung WS, Tahk SJ, Park SW, Park SJ: Effectiveness of sirolimus-eluting stent implantation for the treatment of ostial left anterior descending artery stenosis with intravascular ultrasound guidance. J Am Coll Cardiol; 2005 Sep 6;46(5):787-92
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  • [Title] Effectiveness of sirolimus-eluting stent implantation for the treatment of ostial left anterior descending artery stenosis with intravascular ultrasound guidance.
  • OBJECTIVES: This study was designed to evaluate the clinical and angiographic outcomes of sirolimus-eluting stent (SES) implantation for ostial left anterior descending (LAD) lesions compared with bare-metal stent (BMS) implantation.
  • In the SES group, for complete lesion coverage, stent positioning was intentionally extended into the distal left main coronary artery (LMCA) in 23 patients (34%) with intermediate LMCA narrowing.
  • In the SES group, there were no restenoses in cases with LMCA coverage, compared with three restenoses (7.9%) in cases with precise stent positioning (p = NS).
  • This finding may be associated with reduced neointimal hyperplasia and complete lesion coverage.

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  • (PMID = 16139126.001).
  • [ISSN] 0735-1097
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Delayed-Action Preparations; 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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69. Jong GP, Ma T, Chou P, Shyu MY, Tseng WK, Chang TC: Reciprocal changes in 12-lead electrocardiography can predict left main coronary artery lesion in patients with acute myocardial infarction. Int Heart J; 2006 Jan;47(1):13-20
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  • [Title] Reciprocal changes in 12-lead electrocardiography can predict left main coronary artery lesion in patients with acute myocardial infarction.
  • Acute left main coronary artery (LMCA) occlusion may result in acute myocardial infarction (AMI) or sudden death.
  • ST elevation in the aVR and V1 leads is reported to be valuable in recognizing LMCA occlusion.
  • This study aimed to determine the reciprocal ST segment depression of 12-lead ECGs associated with acute LMCA occlusion.
  • From January 2000 to December 2004, 61 patients who underwent emergency percutaneous coronary intervention in 3 hospitals due to AMI associated with LMCA (n = 18) and a left anterior descending coronary artery (LADCA) (n = 43) proximal lesion were selected.
  • Reciprocal ST segment depression occurred in leads aVF, V(2), V(3), V(4), V(5), and V(6) with significantly higher incidence in the LMCA group than in the LADCA group.
  • Stepwise linear multivariate discriminant analysis indicated that ST segment depression in leads aVF, V(2), and V(4) could distinguish the LMCA group from the LADCA group.
  • We concluded that reciprocal ST segment depression in leads V(2), V(4), and aVF of a 12-lead ECG is an important predictor of acute LMCA occlusion.
  • [MeSH-major] Coronary Occlusion / diagnosis. Electrocardiography. Myocardial Infarction / diagnosis

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  • (PMID = 16479036.001).
  • [ISSN] 1349-2365
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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70. Grand FH, Iqbal S, Zhang L, Russell NH, Chase A, Cross NC: A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy. Exp Hematol; 2007 Nov;35(11):1723-7
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  • [Title] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy.
  • OBJECTIVES: To determine the consequences and significance of an acquired 46XX,t(2;13;2;21)(p13;q12;q33;q11.2) in atypical chronic myeloid leukemia (aCML).
  • RESULTS: Fluorescence in situ hybridization indicated that FLT3 at 13q12 was disrupted and 5'-rapid amplification of cDNA ends polymerase chain reaction identified a novel in-frame mRNA fusion between exon 3 of SPTBN1 (spectrin, beta, nonerythrocytic 1) at chromosome 2p16 and exon 13 of FLT3.
  • To determine if FLT3 might be involved more widely in BCR-ABL-negative aCML, we analyzed 40 cases and found two were internal tandem duplication-positive, but D835 mutations were not observed.
  • CONCLUSION: Although FLT3 abnormalities are uncommon in aCML, SPTBN1-FLT3 is a novel constitutively active tyrosine kinase that appears to responsive to both targeted signal transduction therapy and immunotherapy.
  • [MeSH-major] Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / therapy. Oncogene Proteins, Fusion / analysis. Spectrin / genetics. fms-Like Tyrosine Kinase 3 / genetics


71. Park SJ: Is stenting a preferred option for unprotected left main coronary artery disease in the drug-eluting stent era? Indian Heart J; 2007 Mar-Apr;59(2 Suppl B):B105-12
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  • [Title] Is stenting a preferred option for unprotected left main coronary artery disease in the drug-eluting stent era?
  • Coronary artery bypass graft (CABG) has been the established treatment for left main coronary artery (LMCA) disease.
  • LMCA disease has been considered to be a challenge for interventional cardiologist for more than 25 years.
  • The early experience with drug-eluting stent (DES) in unprotected LMCA reveals reduced rates of restenosis and associated clinical outcomes when compared with patients who were treated with BMS.
  • However, up to now, effectiveness of DES is not enough to replace CABG in LMCA revascularization.
  • Based on these trials, it is likely that, for selected patients, DES may be regarded as a preferred revascularization strategy for LMCA disease.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Disease / therapy. Coronary Restenosis / prevention & control. Drug-Eluting Stents
  • [MeSH-minor] Coronary Artery Bypass. Hospital Mortality. Humans. Randomized Controlled Trials as Topic

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  • (PMID = 19153426.001).
  • [ISSN] 0019-4832
  • [Journal-full-title] Indian heart journal
  • [ISO-abbreviation] Indian Heart J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 39
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72. Yorgun H, Hazırolan T, Kaya EB, Gürses KM, Evranos B, Canpolat U, Karçaaltıncaba M, Ateş AH, Aytemir K, Tokgözoğlu L, Kabakcı G, Oto A: [The prevalence of coronary artery anomalies in patients undergoing multidetector computed tomography for the evaluation of coronary artery disease]. Turk Kardiyol Dern Ars; 2010 Jul;38(5):341-8
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  • [Title] [The prevalence of coronary artery anomalies in patients undergoing multidetector computed tomography for the evaluation of coronary artery disease].
  • OBJECTIVES: Coronary artery anomalies (CAA) can be detected by multidetector computed tomography (MDCT) with a high accuracy.
  • The purpose of this study was to evaluate the prevalence of CAA in subjects undergoing MSCT coronary angiography for the assessment of coronary artery disease.
  • STUDY DESIGN: This retrospective study included 1,056 patients (534 males, 522 females; mean age 58.8±11.5 years) who underwent coronary dual-source 64-slice MDCT for the assessment of coronary artery disease.
  • The reconstructions were obtained in all cardiac phases at 50-millisecond intervals at a slice thickness of 0.75 mm and a reconstruction increment of 0.5 mm.
  • These included high take-off of the left main coronary artery (LMCA) (n=3, 0.3%), absence of the LMCA (n=3, 0.3%), coronary fistula (n=2, 0.2%), right-sided origin of the circumflex artery (n=2, 0.2%), and left anterior descending artery originating from the right coronary artery (n=1, 0.1%).
  • CONCLUSION: Multidetector computed tomography is a reliable and useful noninvasive method to identify and define anomalous coronary arteries and their course and can be used as the first-line diagnostic tool in the evaluation of CAAs.
  • [MeSH-major] Coronary Artery Disease / radiography. Coronary Vessel Anomalies / epidemiology

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  • (PMID = 21200104.001).
  • [ISSN] 1016-5169
  • [Journal-full-title] Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
  • [ISO-abbreviation] Turk Kardiyol Dern Ars
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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73. Toms DR, Cannick L, Stuart RK, Jenrette JM, Terwiliger L: Helical tomotherapy for extramedullary hematopoiesis involving the pericardium in a patient with chronic myeloid leukemia. Jpn J Radiol; 2010 Jul;28(6):476-8
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  • [Title] Helical tomotherapy for extramedullary hematopoiesis involving the pericardium in a patient with chronic myeloid leukemia.
  • The phenomenon occurs in a number of disease states, notably in myelofibrosis, thalassemia, immune thrombocytopenic purpura, sickle cell anemia, polycythemia vera, and myelodysplastic syndrome.
  • The present case report describes a patient with the diagnosis of atypical chronic myeloid leukemia and myelofibrosis who subsequently developed EMH of the pericardium with effusion and tamponade.
  • [MeSH-major] Heart Diseases / radiotherapy. Hematopoiesis, Extramedullary / radiation effects. Leukemia, Myeloid / complications. Pericardium / radiation effects. Tomography, Spiral Computed / methods


74. Wiśniewska-Szmyt J, Kubica J, Sukiennik A, Radomski M, Rychter M, Jabłoński M, Białoszyński T, Koziński M, Grabczewska Z, Grześk G: One-year outcomes of left main coronary artery stenting in patients with cardiogenic shock. Cardiol J; 2007;14(1):67-75
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  • [Title] One-year outcomes of left main coronary artery stenting in patients with cardiogenic shock.
  • The aim of the study was to evaluate the outcomes of angioplasty and stenting in patients with cardiogenic shock caused by left main coronary artery (LMCA) disease.
  • METHODS: A group of 71 consecutive patients managed for LMCA disease in an emergency setting (38 patients in cardiogenic shock and 33 without shock symptoms) were followed up clinically and angiographically for one year.
  • Multivariate analysis revealed the following independent predictors of cardiogenic shock in patients undergoing emergency LMCA angioplasty: STEMI as the reason for intervention (OR 14.1; 95% CI 3.71-53.7; p < 0.0002) and a small minimal lumen diameter before the procedure (OR 0.43; 95% CI 0.2-0.93; p < 0.04).

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  • (PMID = 18651437.001).
  • [ISSN] 1897-5593
  • [Journal-full-title] Cardiology journal
  • [ISO-abbreviation] Cardiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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75. Chieffo A, Morici N, Maisano F, Bonizzoni E, Cosgrave J, Montorfano M, Airoldi F, Carlino M, Michev I, Melzi G, Sangiorgi G, Alfieri O, Colombo A: Percutaneous treatment with drug-eluting stent implantation versus bypass surgery for unprotected left main stenosis: a single-center experience. Circulation; 2006 May 30;113(21):2542-7
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  • [Title] Percutaneous treatment with drug-eluting stent implantation versus bypass surgery for unprotected left main stenosis: a single-center experience.
  • BACKGROUND: Improvements in results with percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may extend their use in patients with left main coronary artery (LMCA) stenosis.
  • METHODS AND RESULTS: Two hundred forty-nine patients with LMCA stenosis were treated with PCI and DES implantation (n=107) or coronary artery bypass grafting (CABG) (n=142), in a single center, between March 2002 and July 2004.
  • At 1 year, there was no statistical difference in the occurrence of death in PCI versus CABG both for the unadjusted (OR=0.291; 95% CI=0.054 to 1.085; P=0.0710) and adjusted analyses (OR=0.331; 95% CI=0.055 to 1.404; P=0.1673).
  • CONCLUSIONS: At 1 year, in this single-center, retrospective experience, there was no difference in the degree of protection against death, stroke, myocardial infarction, and revascularization between PCI with DES and CABG for LMCA disease.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Bypass. Coronary Stenosis / therapy. Stents

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  • [CommentIn] Circulation. 2006 Nov 7;114(19):e573; author reply e575 [17088469.001]
  • [CommentIn] Circulation. 2006 Nov 7;114(19):e574; author reply e575 [17088470.001]
  • [CommentIn] Circulation. 2006 May 30;113(21):2480-4 [16735688.001]
  • (PMID = 16717151.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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76. Tommaso CL: PCI for LMCA stenosis--is it time to ride the rank bull? Catheter Cardiovasc Interv; 2006 Sep;68(3):363-4
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  • [Title] PCI for LMCA stenosis--is it time to ride the rank bull?

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  • (PMID = 16894577.001).
  • [ISSN] 1522-1946
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible
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77. Breccia M, Biondo F, Latagliata R, Carmosino I, Mandelli F, Alimena G: Identification of risk factors in atypical chronic myeloid leukemia. Haematologica; 2006 Nov;91(11):1566-8
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  • [Title] Identification of risk factors in atypical chronic myeloid leukemia.
  • In the WHO classification atypical chronic myeloid leukemia (CML) has been considered as a new distinct clinical entity included in the category of mixed myeloproliferative/myelodysplastic disorders.
  • Little is known about this uncommon disease, whose incidence is about of one-two cases every 100 cases of Ph-positive CML.
  • We analyzed our series of 55 patients diagnosed as having aCML, with the aim of identifying clinical factors of possible prognostic value on survival and acute transformation.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis


78. Park SJ, Kim YH: Percutaneous coronary intervention for unprotected left main coronary artery stenosis. Cardiol Clin; 2010 Feb;28(1):81-95
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  • [Title] Percutaneous coronary intervention for unprotected left main coronary artery stenosis.
  • Because of the long-term benefit of coronary artery bypass graft (CABG) surgery in medical therapy, CABG has been the standard treatment of unprotected left main coronary artery (LMCA) stenosis.
  • However, with the advancement of techniques and equipment, the percutaneous interventional approach for implantation of coronary stents has been shown to be feasible for patients with unprotected LMCA stenosis.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy. Coronary Stenosis / therapy

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  • (PMID = 19962051.001).
  • [ISSN] 1558-2264
  • [Journal-full-title] Cardiology clinics
  • [ISO-abbreviation] Cardiol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 69
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79. Martínez-Ríos MA, Méndez-Ortíz A, Gaspar J, Barragán-García R, Fernández-de-la-Reguera G, González-Quesada CJ: Left main coronary artery stenosis treatment with two paclitaxel-eluting stents in a patient with cardiac allograft vasculopathy. Arch Cardiol Mex; 2008 Oct-Dec;78(4):407-12
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  • [Title] Left main coronary artery stenosis treatment with two paclitaxel-eluting stents in a patient with cardiac allograft vasculopathy.
  • After the first year of transplantation, allograft coronary artery disease (ACAD) is the second main cause of death.
  • We present a case of successful stenting of the left main coronary artery (LMCA) in a patient with ACAD.
  • Coronary angiogram showed a severe stenosis in the proximal segment of the LMCA; we performed stenting with a paclitaxel-eluting stent (PES).
  • Our report suggests the efficacy of PES as ACAD treatment of the unprotected LMCA.

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  • (PMID = 19205549.001).
  • [ISSN] 1405-9940
  • [Journal-full-title] Archivos de cardiología de México
  • [ISO-abbreviation] Arch Cardiol Mex
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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80. Hsu JT, Chu CM, Chang ST, Kao CL, Chung CM: Percutaneous coronary intervention versus coronary artery bypass graft surgery for the treatment of unprotected left main coronary artery stenosis: in-hospital and one year outcome after emergent and elective treatments. Int Heart J; 2008 May;49(3):355-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Percutaneous coronary intervention versus coronary artery bypass graft surgery for the treatment of unprotected left main coronary artery stenosis: in-hospital and one year outcome after emergent and elective treatments.
  • This study attempts to compare the risks and benefits of provisional stenting with drug eluting stents and bypass surgery for left main coronary artery (LMCA) stenosis.
  • Recent improvements in interventional technologies have increased interest in percutaneous treatment of LMCA stenosis.
  • However, application of percutaneous techniques to LMCA has been sporadic and controversial.
  • In-hospital and one year outcomes of coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) cases were compared.
  • From September, 2003 to June, 2005, a total of 59 consecutive patients with de novo unprotected LMCA stenosis were treated with either CABG or PCI.
  • Twenty patients received non-intravascular ultrasound-guided PCI with a stent in the LMCA.
  • At 30-day follow-up, the major adverse cardiac and cerebrovascular event (MACE) rates of mortality, myocardial infarction, cerebral vascular accident, and target vessel revascularization were 25.6% in the CABG group and 5% in the PCI group (P=0.054).
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Bypass. Coronary Stenosis / therapy

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  • (PMID = 18612192.001).
  • [ISSN] 1349-2365
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Japan
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81. Vaseghi M, Lee MS, Currier J, Tobis J, Shapiro S, Aboulhosn J: Percutaneous intervention of left main coronary artery compression by pulmonary artery aneurysm. Catheter Cardiovasc Interv; 2010 Sep 1;76(3):352-6
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  • [Title] Percutaneous intervention of left main coronary artery compression by pulmonary artery aneurysm.
  • BACKGROUND: Extrinsic compression of the left main coronary artery (LMCA) by a pulmonary artery aneurysm (PAA) has become increasingly recognized as an etiology of angina in patients with pulmonary arterial hypertension (PAH).
  • The purpose of this study was to assess the feasibility and efficacy of LMCA stenting in the treatment LMCA stenosis because of PAA.
  • METHODS: Retrospective analysis of data on patients with PAH who presented with angina and underwent percutaneous intervention of their LMCA compression because of PAA was performed.
  • RESULTS: Five patients (age 51 ± 16 years, all female) with PAH presented with angina and underwent LMCA stenting between 2007 and 2009.
  • LMCA compression because of a PAA was diagnosed in all patients with cardiac CT angiography after echocardiography demonstrated an enlarged pulmonary artery.
  • LMCA stenting was successfully performed in all patients with resolution of angina and electrocardiographic abnormalities.
  • CONCLUSIONS: LMCA stenting appears to be a feasible and durable option in patients who present with angina because of compression by PAA.
  • [MeSH-major] Aneurysm / etiology. Angioplasty, Balloon, Coronary. Coronary Stenosis / therapy. Hypertension, Pulmonary / complications. Pulmonary Artery

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  • [CommentIn] Catheter Cardiovasc Interv. 2010 Sep 1;76(3):357-8 [20839347.001]
  • (PMID = 20552652.001).
  • [ISSN] 1522-726X
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Murasato Y: Impact of three-dimensional characteristics of the left main coronary artery bifurcation on outcome of crush stenting. Catheter Cardiovasc Interv; 2007 Feb 1;69(2):248-56
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  • [Title] Impact of three-dimensional characteristics of the left main coronary artery bifurcation on outcome of crush stenting.
  • BACKGROUND: Crush stenting with drug-eluting stents is used to treat left main coronary artery (LMCA) bifurcations.
  • However, the rate of restenosis at the left circumflex (LCX) artery ostium is high.
  • The impact of the three-dimensional (3D) structure of LMCA bifurcation on the outcome of crush stenting with respect to restenosis has not been described.
  • OBJECTIVES: This study examined the stent expansion, deformity, overlapping, and apposition after crush stenting of LMCA bifurcations.
  • METHODS: Bare metal stents were crushed at LMCA bifurcations in a 3D model that reproduced actual angles, such that the stent deployed from the LMCA to the left anterior descending (LAD) artery crushed the stent deployed from the LMCA to the LCX, followed by kissing balloon inflation.
  • RESULTS: In the 3D model, one stent overlapped the other in the distal LMCA, in contrast to the nearly parallel position of the stents observed in a separate two-dimensional model.
  • A narrow LMCA-LCX angle was associated with less expansion of the LCX stent at the ostium than more distally, and with a higher likelihood of incomplete stent apposition.
  • CONCLUSIONS: Overlap of the LAD stent over, as opposed to under, the LCX stent was associated with close apposition of the stent to the vessel on the myocardial side, at the ostium of the LCX artery, where atherosclerotic plaques are likely to be present.
  • The spatial plaque burden and bifurcation angle should be closely examined before crush stenting, and segments should not be left unstented over large plaques.

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17211894.001).
  • [ISSN] 1522-1946
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Tang HC, Wong A, Wong P, Chua TS, Koh TH, Lim ST: Clinical features and outcome of emergency percutaneous intervention of left main coronary artery occlusion in acute myocardial infarction. Singapore Med J; 2007 Dec;48(12):1122-4
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  • [Title] Clinical features and outcome of emergency percutaneous intervention of left main coronary artery occlusion in acute myocardial infarction.
  • INTRODUCTION: Acute myocardial infarction (AMI) due to left main coronary artery (LMCA) occlusion carries a grave prognosis.
  • Large series reporting on the outcome of emergency revascularisation (percutaneous or surgical) of acute LMCA occlusion have been scarce.
  • 11 patients (0.8 percent) underwent percutaneous intervention to the LMCA.
  • The remaining one had angioplasty and stenting to the left main artery.
  • CONCLUSION: Percutaneous revascularisation of acute LMCA occlusion is feasible and the best outcome is seen in stable patients.
  • [MeSH-minor] Acute Disease. Adult. Aged. Cohort Studies. Coronary Angiography. Emergency Treatment. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Risk Factors. Severity of Illness Index. Singapore. Stents. Survival Rate. Treatment Outcome

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  • (PMID = 18043840.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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84. Leslie-Mazwi TM, Avery LL, Sims JR: Intra-arterial air thrombogenesis after cerebral air embolism complicating lower extremity sclerotherapy. Neurocrit Care; 2009;11(2):247-50
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  • [Title] Intra-arterial air thrombogenesis after cerebral air embolism complicating lower extremity sclerotherapy.
  • BACKGROUND: Cerebral arterial gas embolism is a potentially life-threatening event.
  • Sclerotherapy is an extremely rare cause of cerebral arterial gas embolism.
  • METHOD: Case-report RESULTS: A 38-year-old female suffered acute onset of a left middle cerebral artery (LMCA) syndrome with an NIH stroke score of 11 approximately 10 min after lower extremity sclerotherapy.
  • CT angiogram demonstrated LMCA intraarterial air.
  • [MeSH-minor] Adult. Female. Humans. Hyperbaric Oxygenation. Intracranial Embolism / diagnostic imaging. Intracranial Embolism / etiology. Intracranial Embolism / therapy. Middle Cerebral Artery / diagnostic imaging. Sclerosing Solutions / adverse effects. Sclerosing Solutions / therapeutic use. Sclerotherapy / adverse effects. Sodium Tetradecyl Sulfate / adverse effects. Tomography, X-Ray Computed

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  • (PMID = 19294535.001).
  • [ISSN] 1541-6933
  • [Journal-full-title] Neurocritical care
  • [ISO-abbreviation] Neurocrit Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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85. Soulis JV, Giannoglou GD, Papaioannou V, Parcharidis GE, Louridas GE: Low-Density Lipoprotein concentration in the normal Left Coronary Artery tree. Biomed Eng Online; 2008;7:26
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  • [Title] Low-Density Lipoprotein concentration in the normal Left Coronary Artery tree.
  • The resulted model includes the LMCA, LAD, LCxA and their main branches.
  • RESULTS: High concentration of LDL values appears at bifurcation opposite to the flow dividers in the proximal regions of the Left Coronary Artery (LCA) tree, where atherosclerosis frequently occurs.
  • For the high, median and low molecular diffusivities, the peak values of the normalized LDL luminal surface concentration at the LMCA bifurcation reach 1.065, 1.080 and 1.205, respectively.

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  • (PMID = 18925974.001).
  • [ISSN] 1475-925X
  • [Journal-full-title] Biomedical engineering online
  • [ISO-abbreviation] Biomed Eng Online
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lipoproteins, LDL
  • [Other-IDs] NLM/ PMC2615017
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86. Park SJ, Park DW: Left main stenting: is it a different animal? EuroIntervention; 2010 Dec;6 Suppl J:J112-7
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  • [Title] Left main stenting: is it a different animal?
  • For several decades, coronary-artery bypass grafting (CABG) has been regarded as the treatment of choice for patients with unprotected left main coronary artery (LMCA) disease.
  • However, because of marked advancements in techniques of percutaneous coronary intervention (PCI) with stenting and CABG, as well as adjunctive pharmacologic therapy, a new evaluation and review of current indications for optimal revascularisation therapy for LMCA disease may be required to determine the standard of care for these patients.
  • The available current evidence suggests that the composite outcome of death, myocardial infarction and stroke is similar in patients with LMCA disease who are treated with PCI with stenting or CABG, the only difference was the rate of repeat revascularisation.
  • Although PCI can be performed successfully in most LMCA lesions, "high-risk" anatomic subsets, especially involving distal LMCA bifurcation lesions, continue to present unique technical challenges to interventional cardiologists, and, therefore, an integrated approach combing advanced devices, tailored techniques, adjunctive support of physiologic and morphologic evaluation, and adjunctive pharmacologic agents should be reinforced to improve clinical outcomes.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy. Stents

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  • (PMID = 21930474.001).
  • [ISSN] 1969-6213
  • [Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • [ISO-abbreviation] EuroIntervention
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Metals
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87. Fend F, Horn T, Koch I, Vela T, Orazi A: Atypical chronic myeloid leukemia as defined in the WHO classification is a JAK2 V617F negative neoplasm. Leuk Res; 2008 Dec;32(12):1931-5
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  • [Title] Atypical chronic myeloid leukemia as defined in the WHO classification is a JAK2 V617F negative neoplasm.
  • Atypical chronic myeloid leukemia (aCML) as defined by the WHO classification is a rare hematopoietic stem cell disorder, which shows both myeloproliferative as well as myelodysplastic features.
  • Because of the presence of neutrophilic leukocytosis, aCML may resemble chronic myelogenous leukemia.
  • However, in contrast with the latter, aCML lacks a Philadelphia chromosome or the BCR/ABL fusion gene.
  • The molecular pathogenesis of aCML and its relationship to other myeloproliferative neoplasms is unknown.
  • Fifty-nine cases of Philadelphia (Ph) chromosome negative chronic myeloproliferative neoplasms (CMPN) and normal bone marrows (BM) served as controls.
  • None of the nine amplifiable cases of aCML and none of the normal BM controls showed a JAK2 V617F mutation, in contrast to 45/59 (76%) of the Ph chromosome negative CMPN cases.
  • Atypical CML should therefore be considered as a JAK2 negative chronic myeloid neoplasm that remains properly categorized, alongside chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia, within the WHO group of myelodysplastic/myeloproliferative neoplasms.
  • [MeSH-major] Amino Acid Substitution. Janus Kinase 2 / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / classification. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics
  • [MeSH-minor] Blast Crisis / blood. Blast Crisis / pathology. Blood Cell Count. Fusion Proteins, bcr-abl / genetics. Humans. Mastocytosis / pathology. Neutrophils / pathology. Philadelphia Chromosome. World Health Organization


88. Macdonald D, Cross NC: Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy. Pathobiology; 2007;74(2):81-8
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  • [Title] Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy.
  • The term chronic myeloproliferative disorders was originally used by Damashek to describe the link amongst a group of acquired blood diseases.
  • These may be chromosomal translocations resulting in the creation of a fusion kinase gene, examples of which include ABL, FGFR, and PDGFR as seen in disorders CML, 8p11 myeloproliferative syndrome, atypical CML and chronic eosinophilic leukaemia.
  • This abnormality is seen in 30-97% of cases of MPD with the phenotype PV, ET or CIMF.
  • [MeSH-major] Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Hypereosinophilic Syndrome / diagnosis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Myeloproliferative Disorders / diagnosis. Myeloproliferative Disorders / therapy. Protein-Tyrosine Kinases / genetics
  • [MeSH-minor] Chronic Disease. Hematopoiesis / genetics. Humans. Janus Kinase 2 / genetics. Molecular Diagnostic Techniques. Mutant Chimeric Proteins / genetics. Oncogene Proteins, Fusion / genetics. Point Mutation. Polycythemia Vera / diagnosis. Polycythemia Vera / genetics. Polycythemia Vera / therapy. Primary Myelofibrosis / diagnosis. Primary Myelofibrosis / genetics. Primary Myelofibrosis / therapy. Receptor, Fibroblast Growth Factor, Type 1 / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Receptor, Platelet-Derived Growth Factor beta / genetics. Thrombocythemia, Essential / diagnosis. Thrombocythemia, Essential / genetics. Thrombocythemia, Essential / therapy. mRNA Cleavage and Polyadenylation Factors / genetics

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  • (PMID = 17587879.001).
  • [ISSN] 1015-2008
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / FIP1L1-PDGFRA fusion protein, human; 0 / Mutant Chimeric Proteins; 0 / Oncogene Proteins, Fusion; 0 / mRNA Cleavage and Polyadenylation Factors; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2
  • [Number-of-references] 29
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89. Adhya AK, Ahluwalia J, Varma N, Das R, Varma S: Abnormal chromatin clumping in leucocytes of Ph positive chronic myeloid leukemia cases - extending the morphological spectrum. Indian J Pathol Microbiol; 2008 Oct-Dec;51(4):548-50
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  • [Title] Abnormal chromatin clumping in leucocytes of Ph positive chronic myeloid leukemia cases - extending the morphological spectrum.
  • According to the recent World Health Organization (WHO) classification, it is categorized as a variant of atypical chronic myeloid leukemia (aCML) or Ph-negative CML.
  • Most of the cases reported in literature have been negative for the Ph chromosome or the BCR-ABL gene.
  • Till date, Ph positivity has been demonstrated in just one case.
  • We report two more Ph-positive CML cases with abnormal chromatin clumping in neutrophils.
  • These two unusual cases go on to extend the morphological spectrum of granulocytic changes seen in Ph-positive CML.
  • [MeSH-major] Chromatin / ultrastructure. Leukemia, Myeloid, Chronic-Phase / pathology. Neutrophils / pathology. Philadelphia Chromosome

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  • (PMID = 19008593.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Chromatin
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90. de Man K, Patterson M, Kiemeneij F: Bifurcation balloon for left main shock syndrome: facilitating the simultaneous percutaneous reperfusion of the LAD and circumflex. J Invasive Cardiol; 2006 Nov;18(11):E270-2
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  • [Title] Bifurcation balloon for left main shock syndrome: facilitating the simultaneous percutaneous reperfusion of the LAD and circumflex.
  • Acute occlusion of the left main coronary artery frequently causes cardiogenic shock and, when this occurs with an initial TIMI 0 flow, has an extremely poor prognosis.
  • This case describes a distal LMCA occlusion, 2 weeks post-stenting of the proximal LAD and proximal Cx, where this strategy was successfully used as a bridge to surgery.
  • [MeSH-major] Angioplasty, Balloon, Coronary / adverse effects. Catheterization / methods. Coronary Artery Bypass / methods. Coronary Restenosis / surgery. Coronary Thrombosis / surgery. Stents / adverse effects
  • [MeSH-minor] Cardiac Catheterization. Coronary Vessels / physiopathology. Electrocardiography. Equipment Failure. Fatal Outcome. Humans. Male. Middle Aged. Myocardial Infarction / complications. Myocardial Infarction / diagnosis. Myocardial Infarction / therapy. Postoperative Complications. Retreatment. Risk Assessment. Shock, Cardiogenic / diagnosis. Shock, Cardiogenic / etiology. Shock, Cardiogenic / therapy

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  • (PMID = 17090827.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Suter Y, Schoenenberger AW, Toggweiler S, Jamshidi P, Resink T, Erne P: Intravascular ultrasound-based left main coronary artery assessment: comparison between pullback from left anterior descending and circumflex arteries. J Invasive Cardiol; 2009 Sep;21(9):457-60
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  • [Title] Intravascular ultrasound-based left main coronary artery assessment: comparison between pullback from left anterior descending and circumflex arteries.
  • OBJECTIVE: We compared continuous pullback from the left anterior descending artery (LAD) with pullback from the circumflex artery (CX) for the assessment of the left main coronary artery (LMCA) by intravascular ultrasound (IVUS).
  • BACKGROUND: Gray-scale IVUS and virtual histology by IVUS (IVUS-VH) overcome many shortcomings of contrast angiography in diagnostic assessment of the LMCA.
  • METHODS: LMCA morphology was assessed by IVUS in 65 patients referred for elective or rescue coronary angiography.
  • The IVUS-determined degree of stenosis in the LMCA was a mean of 30% +/- 8% (range 15-52%).
  • CONCLUSIONS: Overall, there was excellent reliability between IVUS-based LMCA morphology assessment using pullback from either the LAD or the CX.

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  • [CommentIn] J Invasive Cardiol. 2009 Sep;21(9):461-2 [19726819.001]
  • (PMID = 19726818.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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92. Perreas KG, Dimitriou S, Ntalarizou E, Kalogris P, Amanatidis G, Khoury M, Karatassakis G, Michalis A: Left ostial stenosis surgical angioplasty. Thorac Cardiovasc Surg; 2007 Oct;55(7):424-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Left ostial stenosis surgical angioplasty.
  • BACKGROUND: Left main coronary stenosis, including ostial lesions, is conventionally treated by coronary bypass surgery.
  • Direct surgical reconstruction of the LMCA has been described and theoretically avoids these potential drawbacks.
  • METHODS: From May 1995 until December 2005, 25 patients with ostial left main stenosis underwent surgical angioplasty in our unit.
  • The left main coronary stem was approached anteriorly in all patients.
  • TOE demonstrated a wide open left main coronary artery normal flow pattern, and no aneurysmal dilatation or calcification of the onlay patch in 24 patients.
  • CONCLUSION: Surgical reconstruction of the LMCA is a safe and effective treatment for left main stenosis.
  • Re-institution of normal blood flow through the left main coronary artery possibly confers advantages over bypass surgery.

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  • (PMID = 17902063.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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93. de Jesus Perez VA, Haddad F, Vagelos RH, Fearon W, Feinstein J, Zamanian RT: Angina associated with left main coronary artery compression in pulmonary hypertension. J Heart Lung Transplant; 2009 May;28(5):527-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angina associated with left main coronary artery compression in pulmonary hypertension.
  • Left main coronary artery (LMCA) compression by an enlarged pulmonary artery trunk (PAT) has been associated with angina, but appropriate diagnostic and treatment approaches remain poorly defined.
  • We present two cases of angina caused by LMCA compression from an enlarged pulmonary artery, one of which also presented with new, severe left ventricular systolic dysfunction attributed to myocardial ischemia.
  • Diagnosis of LMCA stenosis was made via coronary angiography followed by computed tomography-gated coronary angiography (CT-CA), which confirmed pulmonary artery enlargement as the source of extrinsic compression.
  • Restoring LMCA patency with percutaneous intervention and/or aggressive treatment of pulmonary hypertension led to significant improvement in angina, cardiac function and quality of life.
  • Given the negative impact on cardiac function, prompt diagnosis and treatment of extrinsic LMCA compression should be considered a priority.
  • [MeSH-major] Angina Pectoris / etiology. Coronary Stenosis / etiology. Hypertension, Pulmonary / complications. Pulmonary Artery
  • [MeSH-minor] Adult. Angioplasty, Balloon, Coronary. Coronary Angiography. Echocardiography. Epoprostenol / therapeutic use. Humans. Male. Middle Aged. Myocardial Ischemia / diagnosis. Myocardial Ischemia / etiology. Myocardial Ischemia / therapy. Piperazines / therapeutic use. Purines / therapeutic use. Sildenafil Citrate. Stents. Sulfones / therapeutic use. Tomography, X-Ray Computed. Ultrasonography, Interventional. Vasodilator Agents / therapeutic use

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  • (PMID = 19416787.001).
  • [ISSN] 1557-3117
  • [Journal-full-title] The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
  • [ISO-abbreviation] J. Heart Lung Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Piperazines; 0 / Purines; 0 / Sulfones; 0 / Vasodilator Agents; BW9B0ZE037 / Sildenafil Citrate; DCR9Z582X0 / Epoprostenol
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94. Jönsson A, Hammar N, Nordquist T, Ivert T: Left main coronary artery stenosis no longer a risk factor for early and late death after coronary artery bypass surgery--an experience covering three decades. Eur J Cardiothorac Surg; 2006 Aug;30(2):311-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Left main coronary artery stenosis no longer a risk factor for early and late death after coronary artery bypass surgery--an experience covering three decades.
  • OBJECTIVE: To analyse early and late mortality after coronary artery bypass grafting (CABG) in patients with and without left main coronary artery (LMCA) stenosis during the 30-year period 1970-1999.
  • METHODS: A total of 1888 of 10,647 patients (18%) who underwent a first isolated CABG at the Karolinska Hospital in Stockholm, Sweden, during 1970-1999 had significant left main coronary artery stenosis.
  • RESULTS: The proportion of patients with LMCA stenosis of all CABG patients increased from 7% during the 1970s to 26% in 1999.
  • During 1970-1984 early mortality was 5.8% in patients with LMCA stenosis compared with 1.5% in patients without LMCA stenosis (odds ratio (OR) 3.7 (95% confidence interval (CI) 1.8-7.6)).
  • The increased risk of early death in patients with LMCA stenosis was neutralised in males during 1985-1994 and in females during 1995-1999.
  • Five-year mortality, exclusive of early deaths, during 1970-1984 was higher in patients with LMCA stenosis (12.8%) than in those without (8.4%) (relative risk 1.7 (95% CI 1.1-2.5)).
  • An increased risk of late mortality in patients with LMCA stenosis was neutralised in males during 1985-1994 and in females during 1995-1999.
  • CONCLUSIONS: During 1970-1999 there was a decrease of early and five-year mortality in patients with LMCA stenosis after CABG despite increase of patient age and risk factors.
  • There were gender differences so that the risk of death in patients with compared with in those without LMCA stenosis was neutralised in males during 1985-1994 and in females during 1994-1999.
  • [MeSH-major] Coronary Artery Bypass. Coronary Stenosis / mortality. Coronary Stenosis / surgery

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  • (PMID = 16829104.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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95. Rostoff P, Wnuk M, Piwowarska W: [Clinical significance of exercise-induced ST-segment elevation in lead aVR and V1 in patients with chronic stable angina pectoris and strongly positive exercise test results]. Pol Arch Med Wewn; 2005 Dec;114(6):1180-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical significance of exercise-induced ST-segment elevation in lead aVR and V1 in patients with chronic stable angina pectoris and strongly positive exercise test results].
  • Clinical significance of exercise-induced ST-segment changes in lead aVR and V1 during strongly positive electrocardiographic exercise test (EET) in patients with chronic stable angina pectoris remains unclear.
  • The aim of the study was to assess the value of lead aVR and V1 on the exercise electrocardiogram for the detection of left main coronary artery stenosis (LMCAS) and its equivalent (LMCASE) in patients with chronic stable angina pectoris and the strongly positive EET result.
  • In patients with isolated exercise-induced ST elevation in lead aVR, the prevalence of LMCAS was five times more frequent than in patients without lead aVR ST elevation (25.8% vs 4.8% p<0.05).
  • There were no differences in the prevalence of LMCASE and multi-vessel coronary disease in the studied groups.
  • In patients with LMCAS significant ST elevation in lead aVR during strongly positive EET were observed (0.25 +/- 0,4 mm vs 1.43 +/- 0.6 mm p = 0.003), whereas there were no significant exercise-induced electrocardiographic changes in lead V1 (0.61 +/- 0.6 mm vs 0.77 +/- 0.6 mm p = 0.08).
  • Sensitivity of isolated exercise-induced ST elevation in lead aVR in detection of LMCAS was 85.0%, specificity - 50.0%, positive predictive value - 25.8%, negative predictive value - 94.2%, and total accuracy - 55.9%.
  • Exercise-induced ST elevation in lead aVR on the strongly positive exercise ECG may detect LMCAS in patients with chronic stable angina pectoris.
  • [MeSH-major] Angina Pectoris / complications. Coronary Disease / diagnosis. Electrocardiography. Exercise Test
  • [MeSH-minor] Adult. Aged. Chronic Disease. Coronary Angiography. Coronary Vessel Anomalies / etiology. Coronary Vessel Anomalies / physiopathology. Diagnosis, Differential. Exercise. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Radionuclide Ventriculography. Sensitivity and Specificity

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  • (PMID = 16789487.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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96. Ionescu CN, Donohue TJ: ECG findings in acute left main coronary artery thrombosis: a case report and review of the literature. Conn Med; 2009 Jun-Jul;73(6):333-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ECG findings in acute left main coronary artery thrombosis: a case report and review of the literature.
  • Acute coronary syndrome due to left main coronary artery (LMCA) thrombosis is a catastrophic event associated with poor prognosis and high in-hospital mortality.
  • Unfortunately, the electrocardiographic manifestations of LMCA thrombosis are nonspecific.
  • This report describes the electrocardiogram (ECG) findings in a patient with LMCA thrombosis.
  • A new right bundle branch block (RBBB) pattern, especially when associated with ST elevation in aVR and V1, should raise suspicion of this diagnosis.
  • [MeSH-major] Coronary Thrombosis / diagnosis. Electrocardiography. Myocardial Infarction / diagnosis
  • [MeSH-minor] Acute Coronary Syndrome / etiology. Acute Coronary Syndrome / therapy. Coronary Artery Bypass. Fatal Outcome. Humans. Male. Middle Aged

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  • (PMID = 19637662.001).
  • [ISSN] 0010-6178
  • [Journal-full-title] Connecticut medicine
  • [ISO-abbreviation] Conn Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 6
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97. CHANCE Study Group: [The immediate and long-term prognosis following unprotected left main coronary artery stenting in Chinese--Chinese Registry of Unprotected Left Main Coronary Artery Stenting (CHANCE Study)]. Zhonghua Xin Xue Guan Bing Za Zhi; 2005 Mar;33(3):210-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The immediate and long-term prognosis following unprotected left main coronary artery stenting in Chinese--Chinese Registry of Unprotected Left Main Coronary Artery Stenting (CHANCE Study)].
  • OBJECTIVE: To evaluate the immediate and long-term outcomes of unprotected left main coronary artery (LMCA) stenting in Chinese patients and to approach the factors affecting the outcomes.
  • From May 1997 to March 2003 all patients in 23 hospitals undergone elective unprotected LMCA stenting with bare metal stents were enrolled into the registry.
  • Isolated LMCA stenosis was in 126 cases (56.2%) and combined with multivessel disease in 98 cases (43.8%).
  • Mean left ventricular EF was 63.9% +/- 12.3%.
  • Stents were successfully implanted into LMCA in 223 cases (99.6%) and into non-LMCA in 91 cases (92.9%).
  • Death developed in 12 cases (5.4%), including cardiac death in 10 cases (4.5%) and non-cardiac death in 2 cases (0.9%), MI in 4 cases (1.8%), TLR of LMCA in 26 cases (11.7%) and accumulated MACE in 36 cases (16.1%).
  • LVEF < 40%, female and LMCA combined with multivessel disease increased mortality, combined multivessel diseases with incomplete revascularization increased MACE.
  • CONCLUSION: Stenting for selected patients with unprotected LMCA stenosis is feasible and safe.
  • Currently, unprotected LMCA stenting should be performed in patients with LVEF >or= 40% and isolated LMCA disease or LMCA combined with multivessel diseases in whom complete revascularization could be obtained or inoperable patients.

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  • (PMID = 15929812.001).
  • [ISSN] 0253-3758
  • [Journal-full-title] Zhonghua xin xue guan bing za zhi
  • [ISO-abbreviation] Zhonghua Xin Xue Guan Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] China
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98. Hu SS, Gao RL, Gao PX, Li LH, Xiong H, Xu B, Yang YJ, Yuan JQ, Zheng Z: [Efficacy of one-stop hybrid revascularization for treatment of unprotected left main coronary artery disease]. Zhonghua Xin Xue Guan Bing Za Zhi; 2010 Jan;38(1):23-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Efficacy of one-stop hybrid revascularization for treatment of unprotected left main coronary artery disease].
  • OBJECTIVE: To evaluate the efficacy of one-stop hybrid coronary revascularization [simultaneous minimally invasive direct coronary artery bypass surgery (MIDCAB) and percutaneous coronary intervention (PCI) procedures performed in an enhanced (or called "hybrid") operative unit] for the treatment of unprotected left main coronary artery (ULMCA) disease.
  • MIDCAB procedure for grafting of the left intramammary artery (LIMA) with the left anterior descending (LAD) artery was first performed via lower partial ministernotomy on the beating heart, followed by PCI on the LMCA disease and non-LAD coronary lesions.
  • LIMA grafts and stents were patent in 5 patients at 1-year follow-up.
  • CONCLUSIONS: Our initial experience demonstrates that one-stop hybrid coronary revascularization provides a reasonable, feasible and safe alternative for selected patients with LMCA diseases.
  • [MeSH-major] Coronary Artery Disease / therapy. Myocardial Revascularization / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angioplasty, Balloon, Coronary. Coronary Artery Bypass, Off-Pump. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 20398483.001).
  • [ISSN] 0253-3758
  • [Journal-full-title] Zhonghua xin xue guan bing za zhi
  • [ISO-abbreviation] Zhonghua Xin Xue Guan Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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99. Furuichi S, Sangiorgi GM, Palloshi A, Godino C, Airoldi F, Montorfano M, Chieffo A, Michev I, Carlino M, Colombo A: Drug-eluting stent implantation in coronary trifurcation lesions. J Invasive Cardiol; 2007 Apr;19(4):157-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: A total of 15 consecutive patients undergoing percutaneous coronary intervention with DES in de novo trifurcation lesions were identified.
  • Lesions were located as follows: 13 (86.7%) at the distal left main coronary artery (LMCA) comprising the left anterior descending artery (LAD), the left circumflex artery (LCX) and an intermediate branch; 1 between the LAD, diagonal, and septal branches; and 1 between the LCX, obtuse marginal and posterior lateral branches.
  • TLR occurred in 3 patients (20%) with LMCA lesions.
  • CONCLUSION: Most trifurcation lesions were found in the distal LMCA.
  • [MeSH-major] Coronary Disease / therapy. Prosthesis Implantation / methods. Stents

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  • [CommentIn] J Invasive Cardiol. 2007 Jun;19(6):284; author reply 284-5 [17541134.001]
  • (PMID = 17404400.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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100. Lindstaedt M, Spiecker M, Perings C, Lawo T, Yazar A, Holland-Letz T, Muegge A, Bojara W, Germing A: How good are experienced interventional cardiologists at predicting the functional significance of intermediate or equivocal left main coronary artery stenoses? Int J Cardiol; 2007 Aug 21;120(2):254-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How good are experienced interventional cardiologists at predicting the functional significance of intermediate or equivocal left main coronary artery stenoses?
  • In patients with intermediate left main stem lesions clinical decision making based on FFR is safe and feasible.
  • This study was performed to assess the accuracy of visual angiographic assessment of intermediate or equivocal left main coronary artery (LMCA) stenoses by experienced interventional cardiologists when taking fractional flow reserve (FFR) measurements as the gold standard.
  • METHODS: Fifty-one patients with intermediate (40-80% diameter stenosis by angiography) or equivocal LMCA disease were evaluated by FFR.
  • CONCLUSIONS: The functional significance of intermediate and equivocal LMCA stenoses should not be based solely on angiographic assessment even by experienced interventional cardiologists.
  • [MeSH-major] Blood Flow Velocity / physiology. Blood Pressure / physiology. Cardiology / standards. Clinical Competence. Coronary Stenosis / diagnosis. Coronary Vessels / physiopathology

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  • (PMID = 17346818.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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