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1. Adhya AK, Ahluwalia J, Varma N, Das R, Varma S: Abnormal chromatin clumping in leucocytes of Ph positive chronic myeloid leukemia cases - extending the morphological spectrum. Indian J Pathol Microbiol; 2008 Oct-Dec;51(4):548-50
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  • [Title] Abnormal chromatin clumping in leucocytes of Ph positive chronic myeloid leukemia cases - extending the morphological spectrum.
  • According to the recent World Health Organization (WHO) classification, it is categorized as a variant of atypical chronic myeloid leukemia (aCML) or Ph-negative CML.
  • Most of the cases reported in literature have been negative for the Ph chromosome or the BCR-ABL gene.
  • Till date, Ph positivity has been demonstrated in just one case.
  • We report two more Ph-positive CML cases with abnormal chromatin clumping in neutrophils.
  • These two unusual cases go on to extend the morphological spectrum of granulocytic changes seen in Ph-positive CML.
  • [MeSH-major] Chromatin / ultrastructure. Leukemia, Myeloid, Chronic-Phase / pathology. Neutrophils / pathology. Philadelphia Chromosome

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  • (PMID = 19008593.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Chromatin
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2. Namboodiri N, Krishnamoorthy KM: Type A aortic dissection with partial ostial occlusion of left main coronary artery. Eur J Echocardiogr; 2008 Jan;9(1):139-40
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  • [Title] Type A aortic dissection with partial ostial occlusion of left main coronary artery.
  • The short axis view of the aorta showed partial obstruction of the left main coronary artery (LMCA) by the intimal flap with turbulent flow at its ostium.

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  • (PMID = 17588497.001).
  • [ISSN] 1532-2114
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [General-notes] NLM/ Original DateCompleted: 20080603
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3. Lindstaedt M, Spiecker M, Lawo T, Yazar A, Mügge A, Bojara W, Germing A: [Angiographic assessment of functionally insignificant left main coronary artery stenoses: reliability compared to intracoronary pressure measurement]. Dtsch Med Wochenschr; 2006 Sep 29;131(39):2134-8
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  • [Title] [Angiographic assessment of functionally insignificant left main coronary artery stenoses: reliability compared to intracoronary pressure measurement].
  • BACKGROUND AND OBJECTIVE: Left main coronary artery disease (LMCA) is still a widely accepted indication for coronary artery bypass surgery.
  • Intermediate LMCA disease, however, often cannot be evaluated reliably on the basis of clinical and angiographic information alone.
  • This study was performed to compare the accuracy of visual angiographic assessment of intermediate LMCA stenoses by experienced interventional cardiologists with functional assessment by FFR in a patient population with excellent long-term outcome after deferral of surgery on the basis of FFR measurements.
  • PATIENTS AND METHODS: 24 of 51 consecutive patients with intermediate LMCA disease were deferred from surgery based on an FFR value of > or = 0.75.
  • CONCLUSION: The functional significance of intermediate or equivocal LMCA lesions should not be based on visual assessment alone, even when performed by experienced interventional cardiologists.
  • [MeSH-major] Blood Pressure / physiology. Blood Pressure Determination / standards. Coronary Angiography / standards. Coronary Circulation / physiology. Coronary Stenosis / diagnosis. Coronary Vessels / physiology

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  • (PMID = 16991027.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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4. Lai YY, Feng L, Wang Z, He Q, Dang H, Shi Y, Lv S, Qin YZ, Huang XJ: [Laboratory study on a rare case of chronic myeloid leukemia with ins(22;9)t(9;13) and Ph-negative]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2010 Apr;18(2):355-8
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  • [Title] [Laboratory study on a rare case of chronic myeloid leukemia with ins(22;9)t(9;13) and Ph-negative].
  • The study aimed to examine a rare case of Philadelphia (Ph)-negative chronic myeloid leukemia (CML) with t(9;13).
  • Chromosome samples were prepared after culture of bone marrow cells for 24 hours, the karyotypes were analyzed by G banding technique.
  • Chromosome painting analysis was performed by using whole chromosome paints for chromosomes 9 and 22.
  • Fluorescence in situ hybridization (FISH) was done with dual color dual fusion LSI bcr/abl probe.
  • Bcr/abl transcripts were detected by real time fluorescence quantitative polymerase chain reaction (RQ-PCR).
  • FISH assay using LSI bcr/abl DNA probe showed a red abl signal inserted into der(22) and a fusion signal of bcr/abl rearrangement was discovered.
  • RQ-PCR detected high copies of bcr/abl transcripts.
  • In conclusion, insertion of bcr/abl rearrangement was a rare variant t(9;22) and could be well detected by molecular techniques, however, regular cytogenetic banding technique and whole chromosome paintings may probably lead a misdiagnosis to such cases.


5. Pikman Y, Levine RL: Advances in the molecular characterization of Philadelphia-negative chronic myeloproliferative disorders. Curr Opin Oncol; 2007 Nov;19(6):628-34
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  • [Title] Advances in the molecular characterization of Philadelphia-negative chronic myeloproliferative disorders.
  • PURPOSE OF REVIEW: The identification and characterization of somatic disease alleles have greatly improved our understanding of the molecular pathogenesis of myeloproliferative disorders.
  • This review focuses on recent studies investigating the role of activated tyrosine kinase signaling in the Philadelphia chromosome negative myeloproliferative disorders.
  • RECENT FINDINGS: Previously identified tyrosine kinase mutations in chronic myeloid leukemia and other myeloproliferative disorders suggested the possibility that polycythemia vera, essential thrombocythemia and primary myelofibrosis are also caused by activated tyrosine kinases.
  • More recently, activating mutations in the thrombopoietin receptor and in JAK2 exon 12 have been identified in JAK2V617F negative myeloproliferative disorders.
  • Subsequent studies are needed to elucidate the cause of myeloproliferative disorders without known disease alleles and to determine if inhibition of JAK2 signaling has therapeutic efficacy in the treatment of polycythemia vera, essential thrombocythemia and primary myelofibrosis.
  • [MeSH-major] Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / pathology. Myeloproliferative Disorders / genetics. Myeloproliferative Disorders / pathology
  • [MeSH-minor] Alleles. Chronic Disease. Humans. Janus Kinase 2 / metabolism. Mutation. Philadelphia Chromosome. Primary Myelofibrosis / diagnosis. Protein-Tyrosine Kinases / metabolism. Receptors, Thrombopoietin / genetics. Signal Transduction. Thrombocythemia, Essential / diagnosis

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  • (PMID = 17906464.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / K08HL082677-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Thrombopoietin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Janus Kinase 2
  • [Number-of-references] 64
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6. Sokmen G, Tuncer C, Sokmen A, Suner A: Clinical and angiographic features of large left main coronary artery aneurysms. Int J Cardiol; 2008 Jan 11;123(2):79-83
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  • [Title] Clinical and angiographic features of large left main coronary artery aneurysms.
  • Coronary artery aneurysms are defined as coronary dilatations which exceed the diameter of normal adjacent segments by 1.5 times.
  • Left main coronary artery (LMCA) is the least frequently involved artery with a prevalence of 0.1%.
  • Majority of coronary artery aneurysms are atherosclerotic in origin.
  • A number of complications have been reported to occur during the course of the disease including thrombosis and distal embolization, myocardial ischemia and/or infarction, dissection, vasospasm, calcification, fistulization and very rarely rupture.
  • Large aneurysms of LMCA represent a potentially fatal condition even without concomitant atherosclerotic coronary disease.
  • Because of rarity of coronary artery aneurysms, it is difficult to standardize treatment.
  • In this article, we presented 4 cases of large LMCA aneurysms with various clinical and angiographic features.
  • [MeSH-major] Coronary Aneurysm / diagnosis. Coronary Angiography

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  • (PMID = 17407794.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 34
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7. Topaz O, Polkampally PR, Mohanty PK, Rizk M, Bangs J, Bernardo NL: Excimer laser debulking for percutaneous coronary intervention in left main coronary artery disease. Lasers Med Sci; 2009 Nov;24(6):955-60
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  • [Title] Excimer laser debulking for percutaneous coronary intervention in left main coronary artery disease.
  • Excimer laser has been successfully applied to complex atherosclerotic plaques in acute coronary syndromes; however, its role in debulking in left main coronary artery disease has not been fully explored.
  • Details of a series of 20 patients who underwent excimer laser revascularization of a spectrum of left main coronary artery lesions are presented.
  • The left main coronary artery was characterized as protected, semi-protected, poorly protected, or unprotected, depending on the presence or absence of patent bypass grafts to the left anterior descending (LAD) and circumflex (CX) arteries.
  • A fully protected left main coronary artery (LMCA) was present in only 20% of the patients.
  • The target lesions included 11(55%) distal LMCA stenoses, six (30%) ostial stenoses, and one (5%) mid-portion lesions.
  • Two (10%) patients had in-stent re-stenosis of the entire length of the LMCA.
  • Successful LMCA intervention was performed in 19 (95%) patients, while in-hospital complications occurred in only one (5%) patient.
  • Subacute/late stent thrombosis developed 3 months after the procedure in one patient, and two patients died from non-cardiac causes during follow-up.
  • Lesions in LMCAs can be revascularized in selected patients by laser debulking and adjunct stenting.
  • Inadequate protection by bypass grafts and decreased left ventricular function do not contradict utilization of excimer laser.
  • Small laser catheters and high energy levels are required during laser debulking of stenoses of left main coronary arteries.
  • [MeSH-major] Angioplasty, Balloon, Laser-Assisted / methods. Coronary Artery Disease / therapy. Lasers, Excimer / therapeutic use

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  • (PMID = 19238505.001).
  • [ISSN] 1435-604X
  • [Journal-full-title] Lasers in medical science
  • [ISO-abbreviation] Lasers Med Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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8. Deininger MW, Cortes J, Paquette R, Park B, Hochhaus A, Baccarani M, Stone R, Fischer T, Kantarjian H, Niederwieser D, Gambacorti-Passerini C, So C, Gathmann I, Goldman JM, Smith D, Druker BJ, Guilhot F: The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells. Cancer; 2007 Oct 1;110(7):1509-19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells.
  • BACKGROUND: Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)-negative cells in some patients with chronic myeloid leukemia (CML) who attained a cytogenetic response to imatinib mesylate.
  • In some patients, CCA/Ph-negative status was associated with myelodysplasia or acute myeloid leukemia.
  • The objective of the current study was to determine the prognostic impact of CCA/Ph-negative cells.
  • METHODS: The authors compared the pretherapeutic risk factors (Kruskall-Wallis test), exposure to cytotoxic drugs (chi-square test), and overall and progression-free survival (Kaplan-Meyer and logistic regression analysis, respectively) of 515 patients with mostly chronic-phase CML who were treated with imatinib mesylate after failure of interferon-alpha according to whether they attained a major cytogenetic response (MCR) (n = 324 patients), an MCR with CCA/Ph-negative status (n = 30 patients), or no MCR (n = 161 patients).
  • RESULTS: CCA/Ph-negative status most frequently involved chromosomes Y, 8, and 7.
  • No significant differences in pretherapeutic risk factors were detected between patients who attained an MCR with and without CCA/Ph-negative cells, except that exposure to alkylating agents was more frequent in patients with CCA/Ph-negative cells, and overall and progression-free survival were identical.
  • CONCLUSIONS: The overall prognosis for patients who had CML with CCA/Ph-negative status was good and was driven by the CML response to imatinib mesylate.
  • Isolated CCA/Ph-negative cells in the absence of morphologic evidence of MDS do not justify a change in therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Chromosome Aberrations. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Benzamides. Chi-Square Distribution. Chronic Disease. Cytogenetic Analysis. Disease-Free Survival. Female. Follow-Up Studies. Humans. Imatinib Mesylate. Interferon-alpha / therapeutic use. Kaplan-Meier Estimate. Logistic Models. Male. Middle Aged. Myelodysplastic Syndromes / chemically induced. Neutropenia / chemically induced. Prognosis. Thrombocytopenia / chemically induced. Treatment Failure. Treatment Outcome


9. Fava C, Cortes J: Philadelphia-negative acute myeloid leukemia with new chromosomal abnormalities developing after first-line imatinib treatment for chronic phase chronic myeloid leukemia. Am J Hematol; 2008 Sep;83(9):755
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  • [Title] Philadelphia-negative acute myeloid leukemia with new chromosomal abnormalities developing after first-line imatinib treatment for chronic phase chronic myeloid leukemia.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Chromosome Aberrations. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / etiology. Leukemia, Myeloid, Chronic-Phase / drug therapy. Neoplasms, Second Primary / chemically induced. Piperazines / adverse effects. Pyrimidines / adverse effects


10. Nassar H, Gotsman I, Gerganski P, Moseri M, Lotan C, Gotsman M: Cutting balloon angioplasty and stent implantation for aorto-ostial lesions: clinical outcome and 1-year follow-up. Clin Cardiol; 2009 Apr;32(4):183-6
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  • BACKGROUND: Percutaneous interventions for aorto-ostial narrowing of native coronary arteries are challenging because of early elastic recoil after the procedure and the high restenosis rate.
  • HYPOTHESIS: The purpose of the study was to evaluate the clinical outcomes of cutting balloon angioplasty and stent implantation for aorto-ostial lesions with a 1-year clinical follow-up.
  • RESULTS: Forty-eight patients underwent balloon angioplasty; 36 of whom had lesions in the ostial right coronary artery, and 12 of whom had lesions in the left main coronary artery (LMCA).
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy. Stents

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  • (PMID = 19353700.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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11. Kim JW, Seo HS, Rha SW, Park CG, Oh DJ: Acute myocardial infarction in a 14-year old boy by thrombotic occlusion of the left main coronary ostium. Int J Cardiol; 2006 Mar 8;107(3):430-1
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  • [Title] Acute myocardial infarction in a 14-year old boy by thrombotic occlusion of the left main coronary ostium.
  • We report the case of a 14-year old boy who was diagnosed with acute myocardial infarction complicated by cardiogenic shock and was treated by primary stenting of thrombotic occluded left main ostium.
  • A prompt stenting to the LMCA saved patient's life.

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  • (PMID = 16503272.001).
  • [ISSN] 0167-5273
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
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12. Chavan D, Ahmad F, Iyer P, Dalvi R, Kulkarni A, Mandava S, Das BR: Cytogenetic investigation in chronic myeloid leukemia: study from an Indian population. Asian Pac J Cancer Prev; 2006 Jul-Sep;7(3):423-6
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  • [Title] Cytogenetic investigation in chronic myeloid leukemia: study from an Indian population.
  • Chronic myeloid leukemia (CML) is a malignant neoplasm of hematopoietic cells characterized by abnormal proliferation of myeloid precursors, decreased rates of self destruction and an arrest in cellular differentiation.
  • It is the most common type of leukemia seen in India, accounting for 30% of all leukemias.
  • Cytogenetic analysis plays a vital and important role in the diagnosis of CML patients.
  • The present study consists of cytogenetic evaluation of 175 CML cases from the Indian population with ages ranging from 6-86 years (mean of 42.8).
  • Among the 164 reported cases, 53 (32.3%) showed a normal karyotype while within the 111 (67.7%) abnormal cases, 96 cases (86.5%) showed the presence of Philadelphia (Ph') chromosome with standard translocation t(9;22); Ph'+ve along with secondary aberrations was detected in 9 (8.1%) cases.
  • Variants of Ph' chromosome were detected in only one case (0.9%).
  • Ph'-ve CML with other chromosomal aberrations were detected in 5 (4.5%) cases, including +8, del 20q, del 11q and marker chromosome.
  • Furthermore, we believe that availability of more advanced molecular techniques can be used as a supportive tool in CML diagnosis even though it cannot fully replace cytogenetics, which remains the backbone for laboratory investigation of the disease.
  • [MeSH-major] Chromosome Aberrations. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bone Marrow / pathology. Child. Female. Humans. India. Karyotyping. Male. Middle Aged. Philadelphia Chromosome. Translocation, Genetic


13. Breccia M, Cannella L, Diverio D, Streponi P, Nanni M, Stefanizzi C, Natalino F, Mecarocci S, Alimena G: Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib. Leuk Res; 2008 Jan;32(1):177-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib.
  • Since very few unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no clear evidence exists concerning their clinical and prognostic implications.
  • We describe here a CML case with normal karyotype at standard cytogenetics and an atypical e6a2 BCR/ABL fusion transcript, presenting at diagnosis isolated thrombocytosis and mild leukopenia; the patient, who was tested negative for JAK2 mutation, obtained a complete response to imatinib.
  • [MeSH-major] Janus Kinase 2 / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Thrombocytosis / diagnosis
  • [MeSH-minor] Adult. Benzamides. Chromosome Breakage. Humans. Imatinib Mesylate. Male. Treatment Outcome


14. Huang HC, Kao HL, Wu XM, Wang SS, Hsu RB, Ho YL, Chen MF: Long-term prognosis in ethnic Chinese patients with unprotected left main coronary artery disease. Clin Res Cardiol; 2010 Jul;99(7):437-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term prognosis in ethnic Chinese patients with unprotected left main coronary artery disease.
  • OBJECTIVE: The aim of this study was to investigate the long-term outcome of unprotected left main coronary artery disease (LMCA) with different therapeutic modalities in Chinese patients.
  • BACKGROUND: Coronary artery bypass graft (CABG) has been considered standard therapy for patients with LMCA disease.
  • Percutaneous coronary intervention (PCI) has recently been alternative choice for unprotected LMCA.
  • Nevertheless, the effects on the long-term outcome of unprotected LMCA by the above-mentioned management in Chinese remains unknown.
  • METHODS: Patients with unprotected LMCA were enrolled at National Taiwan University Hospital from January 1996 to June 2006.
  • In high-risk left ventricular dysfunction, the elderly and renal insufficiency patients, the long-term survival was statistically significantly better in the CABG group.
  • CONCLUSION: For Chinese patients with unprotected left main coronary artery disease, a significant higher risk of cardiovascular death was noted in the medical therapy group.
  • Overall the long-term cardiovascular survival was similar in LMCA patients treated with either PCI or CABG, but CABG provided better survival outcome in high-risk subgroup patients.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Asian Continental Ancestry Group / statistics & numerical data. Coronary Artery Bypass. Coronary Artery Disease / therapy

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  • (PMID = 20229255.001).
  • [ISSN] 1861-0692
  • [Journal-full-title] Clinical research in cardiology : official journal of the German Cardiac Society
  • [ISO-abbreviation] Clin Res Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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15. Hong YJ, Mintz GS, Kim SW, Lu L, Bui AB, Pichard AD, Satler LF, Waksman R, Kent KM, Suddath WO, Weissman NJ: Impact of remodeling on cardiac events in patients with angiographically mild left main coronary artery disease. J Invasive Cardiol; 2007 Dec;19(12):500-5
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  • [Title] Impact of remodeling on cardiac events in patients with angiographically mild left main coronary artery disease.
  • BACKGROUND: The clinical significance of intravascular ultrasound (IVUS) assessed remodeling in left main coronary artery (LMCA) lesions has not been studied.
  • Thus, we evaluated the impact of coronary arterial remodeling on cardiac events in patients with angiographically mild LMCA disease.
  • METHODS: Two hundred thirty-six patients who underwent IVUS evaluation to determine the severity of angiographically mild LMCA lesions (diameter stenosis < 50%) were included.
  • Negative remodeling (NR) was defined as a remodeling index (lesion/reference external elastic membrane crosssectional area [CSA]) < 0.95, intermediate remodeling (IR) as between 0.95-1.05, and positive remodeling (PR) as > 1.05.
  • At 1-year follow up, LMCA-related cardiac events occurred in 15 patients (6.3%).
  • NR was less frequently associated with LMCA-related cardiac events than IR/PR [6/156 (3.8%) vs. 9/80 (11.3%); p = 0.027].
  • In lesions associated with LMCA-related events, lumen CSA was smaller, plaque burden was larger, and the remodeling index was greater than in lesions not associated with cardiac events, but only non-NR was an independent predictor of LMCA-related events in patients with mild LMCA disease (hazard ratio 4.095; 95% CI, 1.275-13.149; p = 0.018).
  • CONCLUSIONS: Angiographically mild LMCA disease was more frequently associated with NR, and NR was associated with fewer LMCA-related cardiac events in patients with mild LMCA lesions.
  • [MeSH-major] Coronary Angiography / methods. Coronary Disease / radiography. Coronary Vessels / physiopathology
  • [MeSH-minor] Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Ultrasonography, Interventional

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  • (PMID = 18180518.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Imamaki M, Matsuura K, Sakurai M, Shimura H, Ishida A, Miyazaki M: Evaluation of early and midterm results of offpump coronary artery bypass in patients with left main disease. J Card Surg; 2009 Mar-Apr;24(2):162-6
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  • [Title] Evaluation of early and midterm results of offpump coronary artery bypass in patients with left main disease.
  • PURPOSE: This study evaluated the early and midterm results of offpump coronary artery bypass (OPCAB) for left main coronary artery (LMCA) stenosis.
  • METHODS: Patients treated between November 2001 and December 2006, during which isolated coronary artery bypass grafting (CABG) was performed without cardiopulmonary bypass in principle, were included.
  • Isolated CABG was performed in 206 patients, of whom 62 (30.1%) had LMCA stenosis >50%.
  • RESULTS: The in-hospital mortality rate (LMCA stenosis > 50%, 1.6%; LMCA stenosis <or=50%, 0.7%, p = 0.512), the incidence of postoperative complications, and the midterm survival rate (LMCA stenosis succeeds50%, 86.7 +/- 5.2%/5 years, LMCA stenosis<or=50%, 89.6 +/- 3.8%/5 years, p = 0.21) did not significantly differ between the two groups.
  • Conversion was significantly frequent in patients with LMCA stenosis >75% and severe stenosis >90% in the right coronary artery (RCA) trunk.
  • CONCLUSIONS: Patients with LMCA stenosis can undergo OPCAB safely and the midterm results are good.
  • As conversion was significantly frequent in patients with severe LMCA and RCA trunk stenosis, adequate preparation for pump application is necessary.
  • [MeSH-major] Coronary Artery Bypass, Off-Pump / statistics & numerical data. Coronary Stenosis / surgery

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  • (PMID = 19267825.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Mahesh B, Navaratnarajah M, Mensah K, Amrani M: Treatment of high-output coronary artery fistula by off-pump coronary artery bypass grafting and ligation of fistula. Interact Cardiovasc Thorac Surg; 2009 Jul;9(1):124-6
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  • [Title] Treatment of high-output coronary artery fistula by off-pump coronary artery bypass grafting and ligation of fistula.
  • Coronary artery fistulas (CAF) are uncommon entities often associated with myocardial ischemia and high output failure.
  • Surgical options include ligation of the fistula, with/without simultaneous coronary artery bypass grafting (CABG).
  • We report a case of left main coronary artery (LMCA) fistula to the coronary sinus (CS), which was associated with high-output bi-ventricular failure, and moderate mitral (MR) and tricuspid regurgitation (TR), related to the volume overload and annular dilatation.
  • This was tackled elegantly by off-pump CABG to protect the territories supplied by the LMCA, followed by ligation of the fistula.
  • [MeSH-major] Arteriovenous Fistula / surgery. Cardiac Output, High / surgery. Coronary Artery Bypass, Off-Pump. Coronary Sinus / surgery

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  • (PMID = 19346222.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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18. Inan BK, Ucak A, Gullu AU, Temizkan V, Ugur M, Yilmaz AT: Left main coronary artery and supravalvular aortic stenosis in adult: treatment with ostial patchplasty and modified Brom procedure. J Card Surg; 2009 May-Jun;24(3):299-300
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  • [Title] Left main coronary artery and supravalvular aortic stenosis in adult: treatment with ostial patchplasty and modified Brom procedure.
  • Left main coronary artery (LMCA) stenosis accompanying to supravalvular aortic stenosis is a very uncommon, serious congenital abnormality.
  • Aortic valve leaflet fusions and intimal thickening of the aortic valve leaflets and coronary artery are the underlying pathologies for the LMCA stenosis.
  • We operated on a 21-year-old male patient for supravalvar aortic stenosis with LMCA ostial stenosis.
  • We enlarged the LMCA with a pericardial patch (ostial plasty) and reconstructed the aortic root with a modified Brom procedure.
  • Postoperative course was uneventful; echocardiographic evaluation revealed a normal functioning aortic valve with a normal left ventricular function.
  • Gradient at left ventricular outflow tract was decreased a great deal.
  • Although supravalvular aortic stenosis with LMCA stenosis is a very rare congenital abnormality, this clinical entity can be successfully corrected with detailed and selected surgical procedures.

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  • (PMID = 19438785.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polyethylene Terephthalates
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19. Tatli E: Thrombotic occlusion of the ostial left main coronary artery in a patient with acute coronary syndrome. Neth Heart J; 2009 Aug;17(7-8):295-6
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  • [Title] Thrombotic occlusion of the ostial left main coronary artery in a patient with acute coronary syndrome.
  • Ostial left main coronary artery (LMCA) occlusion is rarely seen in patients with acute coronary syndrome.
  • Acute coronary syndrome resulting from an LMCA occlusion is associated with a significant morbidity and mortality rate, if it is managed with fibrinolysis.
  • Electrocardiography can predict LMCA occlusion in patients with acute coronary syndrome.
  • We report a 52-year-old male who presented with acute coronary syndrome and ostial LMCA occlusion. (Neth Heart J 2009;17:295-6.).

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  • [Cites] Int J Cardiol. 2007 Apr 4;116(3):e83-4 [17126932.001]
  • [Cites] Jpn Heart J. 2000 Sep;41(5):571-81 [11132164.001]
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  • (PMID = 19789699.001).
  • [ISSN] 1568-5888
  • [Journal-full-title] Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
  • [ISO-abbreviation] Neth Heart J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2743820
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20. Lehmann R, Spyridopoulos I, Kremer J, Zeiher AM, Schächinger V, Fichtlscherer S: Favorable long-term survival in patients undergoing stent PCI of unprotected left main coronary artery compared to predicted short-term prognosis of CABG estimated by EuroSCORE: clinical determinants of long-term outcome. J Interv Cardiol; 2009 Aug;22(4):311-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Favorable long-term survival in patients undergoing stent PCI of unprotected left main coronary artery compared to predicted short-term prognosis of CABG estimated by EuroSCORE: clinical determinants of long-term outcome.
  • AIMS/METHODS: The long-term outcome of patients (pts) undergoing percutaneous coronary intervention (PCI) of unprotected left main coronary artery (LMCA) is unclear so far.
  • We prospectively investigated the outcome of 102 consecutive patients who underwent stent PCI of unprotected LMCA.
  • Patients were divided according to clinical indication for PCI: stable coronary artery disease (CAD) (N = 60), NSTEMI (N = 18), STEMI (N = 24).
  • Expected in-hospital mortality of coronary artery bypass grafting (CABG) was calculated using the European System for Cardiac Operative Risk Evaluation (EuroSCORE) and compared to the observed survival rate during long-term follow-up (mean 1.8 +/- 1.2 years).
  • Prognostically relevant patient related factors (P < 0.01) included severely reduced left ventricular ejection fraction (HR 3.24), ACS (HR 3.18), STEMI (HR: 3.01), Killip class IV (HR 7.69), occurrence of neoplastic disease (HR 3.97), and elevated CRP (HR 3.86).
  • CONCLUSIONS: LMCA-PCI was associated with lower long-term mortality rates compared to the estimated mortality of CABG.
  • This prospective observational study suggests that DES-PCI of unprotected LMCA in "all-comers" can be carried out with reasonable risk.
  • [MeSH-major] Angioplasty, Balloon, Coronary / mortality. Coronary Artery Bypass / mortality. Coronary Artery Disease / therapy. Coronary Vessels / pathology. Stents


21. Leesar MA, Mintz GS: Hemodynamic and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosis. Catheter Cardiovasc Interv; 2007 Nov 1;70(5):721-30
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  • [Title] Hemodynamic and intravascular ultrasound assessment of an ambiguous left main coronary artery stenosis.
  • The assessment of the left main coronary artery (LMCA) stenosis by angiography is not reliable, and noninvasive tests are incapable of discriminating ischemia caused by LMCA versus other stenoses.
  • Among patients with LMCA stenosis, both fractional flow reserve and intravascular ultrasound parameters would determine the severity of stenosis and predict the event rates.
  • This review outlines the evidence in support of their routine use for the assessment of an ambiguous LMCA stenosis.

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17960644.001).
  • [ISSN] 1522-1946
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Lindsey JB, Brilakis ES, Banerjee S: Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention. Cardiovasc Revasc Med; 2008 Jan-Mar;9(1):47-51
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  • [Title] Acute coronary syndrome due to extrinsic compression of the left main coronary artery in a patient with severe pulmonary hypertension: successful treatment with percutaneous coronary intervention.
  • A patient with severe pulmonary (arterial) hypertension (PH) presented with a non-ST segment elevation myocardial infarction and recurrent angina at rest.
  • Coronary angiography showed severe ostial left main coronary artery (LMCA) stenosis; coronary arteries were otherwise normal.
  • Intravascular ultrasonography (IVUS) showed deformation of the LMCA due to extrinsic compression from a markedly dilated main pulmonary artery, which was confirmed by cardiac computed tomography.
  • The LMCA was successfully stented using a paclitaxel-eluting stent resulting in complete resolution of angina.
  • Extrinsic compression of the LMCA should be considered in patients with severe PH and angina; IVUS may aid in the diagnosis.
  • [MeSH-major] Acute Coronary Syndrome / therapy. Angioplasty, Balloon, Coronary. Coronary Stenosis / therapy. Hypertension, Pulmonary / complications. Pulmonary Artery / pathology

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  • (PMID = 18206638.001).
  • [ISSN] 1878-0938
  • [Journal-full-title] Cardiovascular revascularization medicine : including molecular interventions
  • [ISO-abbreviation] Cardiovasc Revasc Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cardiovascular Agents; 0 / Platelet Aggregation Inhibitors; P88XT4IS4D / Paclitaxel
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23. Fujiwara S, Muroi K, Kikuchi S, Kawano-Yamamoto C, Matsuyama T, Mori M, Nagai T, Akutsu M, Ozawa K: Development of streptococcus meningitis and Epstein-Barr virus reactivation after non-T-cell-depleted human leukocyte antigen-haploidentical peripheral blood stem cell transplantation based on feto-maternal microchimerism. Leuk Lymphoma; 2007 Mar;48(3):640-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] HLA Antigens / metabolism. Herpesvirus 4, Human / physiology. Meningitis, Pneumococcal / diagnosis. Peripheral Blood Stem Cell Transplantation. Streptococcus / physiology. Transplantation Chimera / genetics. Virus Activation / physiology
  • [MeSH-minor] Adolescent. Graft vs Host Disease. Humans. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / immunology. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / therapy. Lymphocyte Depletion. Male. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy. T-Lymphocytes / immunology. Transplantation Conditioning. Transplantation, Homologous

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  • (PMID = 17454615.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HLA Antigens
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24. Burzotta F, Trani C, Coroleu S: Retrograde recanalization of left main from saphenous vein graft supported by percutaneous Impella Recover LP 2.5 assist device. J Invasive Cardiol; 2009 Aug;21(8):E147-50
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  • [Title] Retrograde recanalization of left main from saphenous vein graft supported by percutaneous Impella Recover LP 2.5 assist device.
  • Percutaneous coronary interventions (PCI) in patients with severely depressed left ventricular (LV) function and in those with chronic total occlusions are technically challenging and at high risk of complications.
  • Here we report a case of successful retrograde transradial recanalization and stenting of a chronically occluded left main coronary artery (LMCA) from a saphenous vein graft supported by the Impella Recover LP 2.5 assist device.

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  • (PMID = 19652264.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Ozmen N, Yiginer O, Uz O, Kardesoglu E, Aparci M, Isilak Z, Cingozbay BY, Cebeci BS, Kocum HT: ST elevation in the lead aVR during exercise treadmill testing may indicate left main coronary artery disease. Kardiol Pol; 2010 Oct;68(10):1107-11
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  • [Title] ST elevation in the lead aVR during exercise treadmill testing may indicate left main coronary artery disease.
  • BACKGROUND: exercise treadmill testing (ETT) is the most widely used method for evaluating patients with coronary artery disease.
  • Predicting the left main coronary artery (LMCA) disease before invasive procedures is very important in risk assessment because of its severe clinical outcome.
  • AIM: To examine whether ST elevation in lead aVR during ETT may suggest LMCA disease since the lead aVR is the reciprocal lead of LMCA.
  • RESULTS: coronary angiography in the study group revealed significant LMCA stenosis in 16 (76%) patients, whereas LMCA disease was present in only 3 (8%) patients from the control group.
  • There was no significant coronary artery stenosis in 5 patients in the study group and 12 patients in the control group.
  • Of the 16 patients who had LMCA stenosis, 9 had isolated LMCA disease and 7 had additional stenotic lesions in LAD or circumflex coronary arteries.
  • The values of positive and negative predictive value of this finding in diagnosing the presence of LMCA were 76% and 93%, respectively.
  • CONCLUSIONS: ST segment elevation in lead aVR during ETT may point to a high probability of the presence of LMCA disease.
  • [MeSH-major] Coronary Stenosis / diagnosis. Coronary Vessels / pathology. Electrocardiography. Exercise Test

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  • [CommentIn] Kardiol Pol. 2010 Oct;68(10):1112-4 [20967705.001]
  • (PMID = 20967704.001).
  • [ISSN] 0022-9032
  • [Journal-full-title] Kardiologia polska
  • [ISO-abbreviation] Kardiol Pol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
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26. Dragu R, Kerner A, Gruberg L, Rispler S, Lessick J, Ghersin E, Litmanovich D, Engel A, Beyar R, Roguin A: Angiographically uncertain left main coronary artery narrowings: correlation with multidetector computed tomography and intravascular ultrasound. Int J Cardiovasc Imaging; 2008 Jun;24(5):557-63
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  • [Title] Angiographically uncertain left main coronary artery narrowings: correlation with multidetector computed tomography and intravascular ultrasound.
  • BACKGROUND: Angiographic assessment of left main coronary artery (LMCA) stenosis is often difficult and unreliable.
  • To date, intravascular ultrasound (IVUS) is used to determine the significance of lesions in patients with LMCA stenosis of uncertain significance.
  • We aimed to prospectively show the ability of multidetector computed tomography (MDCT) to assess LMCA luminal and plaque dimensions, and to characterize atherosclerotic plaque, as compared to IVUS and quantitative coronary angiography (QCA), in patients with angiographically uncertain LMCA stenosis.
  • METHODS: Twenty patients, with angiographically uncertain LMCA stenosis, underwent coronary evaluation with IVUS, QCA and 16-slice MDCT.
  • CONCLUSION: A high degree of correlation was found between MDCT and IVUS regarding the assessment of minimal lumen diameter and area, lumen area stenosis and plaque burden as well as plaque characterization in patients with angiographically borderline LMCA stenosis.
  • Therefore, in patients selected for non-invasive coronary tree evaluation, MDCT may provide a valuable tool for the assessment, decision-making and follow-up of patients with uncertain LMCA disease.

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  • (PMID = 18165931.001).
  • [ISSN] 1569-5794
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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27. Duygu H, Yavuzgil O, Erturk U, Zoghi M, Ozerkan F: ST-segment elevation in lead augmented vector right may also be caused by diffuse left main coronary artery vasospasm without fixed stenosis. Clin Cardiol; 2008 Apr;31(4):179-82
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  • [Title] ST-segment elevation in lead augmented vector right may also be caused by diffuse left main coronary artery vasospasm without fixed stenosis.
  • The ST-segment elevation in this aVR in the patient with clinically suspected acute coronary syndrome suggests a strong possibility of left main coronary artery (LMCA) obstruction due to fixed stenosis.
  • In this article, we report the first case, to our knowledge, of ST-segment elevation in lead aVR due to diffuse LMCA spasm.
  • [MeSH-major] Coronary Vasospasm / diagnosis. Electrocardiography
  • [MeSH-minor] Acute Coronary Syndrome / diagnosis. Angina Pectoris. Coronary Angiography. Coronary Stenosis / complications. Humans. Male. Middle Aged

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  • [Copyright] Copyright (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18404728.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Cohenpour M, Tourovski A, Zyssman I, Friedensohn A, Gayer G, Horne T: Anomalous origin of left main coronary artery: the value of myocardial scintigraphic and spiral computed tomography scans. Nucl Med Rev Cent East Eur; 2006;9(1):69-71
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  • [Title] Anomalous origin of left main coronary artery: the value of myocardial scintigraphic and spiral computed tomography scans.
  • Anomalous origin of the left main coronary artery (LMCA) from the right sinus of the Valsalva or the proximal right coronary artery (RCA) is one of the most clinically important anomalies of coronary circulation.
  • The exact anatomic course of anomalous LMCA was confirmed using contrast enhanced computed tomography.
  • [MeSH-minor] Adult. Coronary Angiography. Coronary Vessel Anomalies / diagnosis. Coronary Vessel Anomalies / pathology. Female. Humans. Perfusion. Thallium / pharmacology. Tomography, Emission-Computed, Single-Photon / methods

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  • (PMID = 16791809.001).
  • [ISSN] 1506-9680
  • [Journal-full-title] Nuclear medicine review. Central & Eastern Europe
  • [ISO-abbreviation] Nucl Med Rev Cent East Eur
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] AD84R52XLF / Thallium
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29. Fukuhara T, Kakinoki Y: [Clinical features of a new category, myelodysplastic/myeloproliferative diseases, defined by WHO classification]. Rinsho Byori; 2006 Mar;54(3):243-9
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  • The WHO classification published in 2001 defined a new category of hematological disease, myelodysplastic/myeloproliferative diseases (MDS/MPD), that have both myelodysplasia and myeloproliferation at the time of initial presentation.
  • This category consists of four subclasses, chronic myelomonocytic leukemia (CMML), atypical CML(aCML), juvenile chronic myelogenous leukemia and MDS/MPD-unclassifiable (MDS/MPD-u).
  • By reviewing the data of each case according to the criteria, we diagnosed 31 cases of MDS/MPD, including 22 cases of CMML, 5 cases of aCML and 4 cases of MDS/MPD-u.
  • It is noteworthy that blast crisis in CMML exclusively occurred within one year after diagnosis.
  • Young age, a high percentage of blasts in the peripheral blood, splenomegaly, lymphadenopathy and clonal cytogenetic abnormality were associated with blast crisis.
  • It is suggested that there are two subgroups in CMML which differ in disease progression.

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  • (PMID = 16637572.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / Receptors, Immunologic
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30. Chen SL, Ye F, Zhang JJ, Liu ZZ, Lin S, Zhu ZS, Sun XW, Li F, Zhang AP, Chen JG, Ji QJ, Qian J, Chen F, Kwan TW: Distal left main coronary bifurcation lesions predict worse outcome in patients undergoing percutaneous implantation of drug-eluting stents: results from the Drug-Eluting Stent for the Treatment of Left Main Disease (DISTAL) Study. Cardiology; 2009;113(4):264-73
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  • [Title] Distal left main coronary bifurcation lesions predict worse outcome in patients undergoing percutaneous implantation of drug-eluting stents: results from the Drug-Eluting Stent for the Treatment of Left Main Disease (DISTAL) Study.
  • OBJECTIVES: We investigated the clinical outcome of stenting of unprotected left main coronary artery (LMCA).
  • METHODS: We studied 164 patients with nonbifurcated LMCA lesions (group A) and 96 patients with distal bifurcated lesions (group B).
  • There were significant differences in major adverse cardiac events at 1 (p = 0.014) and 2 years (p = 0.002) between group B (19.8%, 25.0%) and group A (9.1%, 10.4%), mainly due to increased target-vessel revascularization (16.7, 21.9% in group B vs. 6.1, 7.3% in group A, p = 0.006 and 0.001, respectively).
  • The double-stent technique was associated with worse outcomes at 1 year in group B compared to group A.
  • Bifurcation lesions (HR 3.42, 95% CI 1.34-5.61, p = 0.001), diabetes (HR 2.68, 95% CI 2.01-12.11, p = 0.015), three-vessel disease (HR 0.83, 95% CI 0.27-0.96, p = 0.001), incomplete revascularization (HR 0.15, 95% CI 0.11-0.35, p = 0.001) and stent diameter (HR 5.05, 95% CI 2.71-10.01, p = 0.03) were the independent factors of major adverse cardiac events in the whole patient cohort.
  • CONCLUSION: Stenting unprotected distal bifurcated LMCA was associated with unfavorable results when compared to stenting other LMCA lesions.
  • [MeSH-major] Angioplasty, Balloon, Coronary / adverse effects. Coronary Angiography. Coronary Artery Disease / radiography. Coronary Artery Disease / therapy. Drug-Eluting Stents / adverse effects
  • [MeSH-minor] Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Predictive Value of Tests. Prevalence. Proportional Hazards Models. Registries. Risk Factors. Stroke Volume. Treatment Failure. Treatment Outcome

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] Cardiology. 2009;113(4):260-3 [19246904.001]
  • (PMID = 19246905.001).
  • [ISSN] 1421-9751
  • [Journal-full-title] Cardiology
  • [ISO-abbreviation] Cardiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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31. Levisman J, Budoff M, Karlsberg R: Congenital atresia of the left main coronary artery: cardiac CT. Catheter Cardiovasc Interv; 2009 Sep 1;74(3):465-7
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  • [Title] Congenital atresia of the left main coronary artery: cardiac CT.
  • Congenital coronary artery disease is a rare occurrence, and atresia of the left main is one of the least frequently observed variations.
  • In a recent review of 1,950 angiograms, 110 congenital coronary anomalies were seen, and of those, only 13 cases represented an absent left main coronary artery (LMCA).
  • This case is of a 53-year-old male who initially presented 2 years prior for atypical chest pain.
  • The anatomy described in this case is typical for LMCA atresia.

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19472349.001).
  • [ISSN] 1522-726X
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Botsios S, Maatz W, Sprengel U, Heuer H, Walterbusch G: Patch angioplasty for isolated ostial stenosis of the left main coronary artery. J Card Surg; 2008 Nov-Dec;23(6):743-6
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  • [Title] Patch angioplasty for isolated ostial stenosis of the left main coronary artery.
  • BACKGROUND: Conventional coronary artery bypass grafting (CABG) is recognized as the treatment of choice for left main coronary artery stenosis (LMCA) with excellent results.
  • Patch angioplasty is an alternative method in selected cases for ostial stenosis of the LMCA.
  • Therefore, the aim of this study was to evaluate the long-term outcome of patients treated by patch angioplasty using saphenous vein for ostial stenosis of the LMCA.
  • METHODS: Nineteen patients underwent vein patch angioplasty for ostial LMCA stenosis between 1995 and 2005 at our institution.
  • On three of them simultaneous aortic valve replacement was carried out and on one patient concomitant coronary artery bypass grafting of the right coronary artery was performed.
  • CONCLUSIONS: Surgical patch angioplasty with saphenous vein for isolated ostial LMCA stenosis is a safe operative technique with good long-term results.
  • MRI is able to adequately depict the operative result of left main coronary ostium reconstruction.

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  • (PMID = 19017004.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Mehilli J, Kastrati A, Byrne RA, Bruskina O, Iijima R, Schulz S, Pache J, Seyfarth M, Massberg S, Laugwitz KL, Dirschinger J, Schömig A, LEFT-MAIN Intracoronary Stenting and Angiographic Results: Drug-Eluting Stents for Unprotected Coronary Left Main Lesions Study Investigators: Paclitaxel- versus sirolimus-eluting stents for unprotected left main coronary artery disease. J Am Coll Cardiol; 2009 May 12;53(19):1760-8
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  • [Title] Paclitaxel- versus sirolimus-eluting stents for unprotected left main coronary artery disease.
  • OBJECTIVES: The aim of this trial was to compare the safety and efficacy of paclitaxel-eluting stents (PES) and sirolimus-eluting stents (SES) for treatment of unprotected left main coronary artery (uLMCA) disease.
  • METHODS: In this randomized study, 607 patients with symptomatic coronary artery disease undergoing percutaneous coronary intervention for uLMCA were enrolled: 302 were assigned to receive a PES (Taxus, Boston Scientific, Natick, Massachusetts) and 305 assigned to receive a SES (Cypher, Cordis, Johnson & Johnson, New Brunswick, New Jersey).
  • The primary end point was the combined incidence of death, myocardial infarction, and target lesion revascularization (TLR) at 1 year.
  • The secondary end point was angiographic restenosis on the basis of the LMCA area analysis at follow-up angiography.
  • RESULTS: At 1 year the cumulative incidence of death, myocardial infarction, or TLR was 13.6% in the PES and 15.8% in the SES group (relative risk [RR]: 0.85, 95% confidence interval [CI]: 0.56 to 1.29, p = 0.44).
  • CONCLUSIONS: Implantation of either PES or SES in uLMCA lesions is safe and effective; both of these drug-eluting stents provide comparable clinical and angiographic outcomes. (Drug-Eluting-Stents for Unprotected Left Main Stem Disease [ISAR-LEFT-MAIN]; NCT00133237).
  • [MeSH-major] Coronary Artery Disease / drug therapy. Coronary Restenosis / drug therapy. Drug-Eluting Stents. Immunosuppressive Agents / therapeutic use. Paclitaxel / therapeutic use. Sirolimus / therapeutic use. Tubulin Modulators / therapeutic use

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  • [CommentIn] J Am Coll Cardiol. 2009 May 12;53(19):1769-72 [19422983.001]
  • (PMID = 19422982.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00133237
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Platelet Aggregation Inhibitors; 0 / Tubulin Modulators; A74586SNO7 / clopidogrel; OM90ZUW7M1 / Ticlopidine; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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34. Batyraliev TA, Fettser DV, Karben ZA, Sidorenko BA: [Stenting of unprotected left main coronary artery: complications during 3 years follow up]. Kardiologiia; 2009;49(2):22-6
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  • [Title] [Stenting of unprotected left main coronary artery: complications during 3 years follow up].
  • Aim of investigation was to study complications during 3 years follow up of patients after implantation of standard metal stents (SMS) in unprotected left main coronary artery (LMCA).
  • Patients with high risk of surgery (n=124) with stenting of unprotected LMCA performed between August 2002 and November 2004 were included in this investigation.
  • Peripheral complications were noted in 1 case: in one patient pseudoaneurism of femoral artery developed and was successfully resolved by compression under ultrasound control.
  • Despite high success of PCI of unprotected LMCA with the use of SMS and relatively low percent of restenosis it is necessary to use this method carefully in the treatment of patients with lesions in unprotected LMCA.
  • We consider PCI in unprotected LMCA justified only in patients with high risk of surgical intervention who are not suitable candidates for coronary bypass surgery.
  • [MeSH-major] Angioplasty, Balloon, Coronary / methods. Coronary Disease / surgery. Postoperative Complications / epidemiology. Stents

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  • (PMID = 19254212.001).
  • [ISSN] 0022-9040
  • [Journal-full-title] Kardiologiia
  • [ISO-abbreviation] Kardiologiia
  • [Language] rus
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Russia (Federation)
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35. Biemond BJ: Treatment considerations for primary myelofibrosis. Neth J Med; 2010 Aug;68(1):291-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Anemia / drug therapy. Anemia / etiology. Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents / therapeutic use. Humans. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / mortality. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / therapy. Neovascularization, Pathologic. Prognosis. Risk Factors. Thalidomide / analogs & derivatives. Thalidomide / therapeutic use

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  • (PMID = 20739724.001).
  • [ISSN] 1872-9061
  • [Journal-full-title] The Netherlands journal of medicine
  • [ISO-abbreviation] Neth J Med
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 4Z8R6ORS6L / Thalidomide; F0P408N6V4 / lenalidomide
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36. Lim TH, Tien SL, Lim P, Lim AS: The incidence and patterns of BCR/ABL rearrangements in chronic myeloid leukaemia (CML) using fluorescence in situ hybridisation (FISH). Ann Acad Med Singapore; 2005 Oct;34(9):533-8
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  • [Title] The incidence and patterns of BCR/ABL rearrangements in chronic myeloid leukaemia (CML) using fluorescence in situ hybridisation (FISH).
  • INTRODUCTION: Chronic myeloid leukaemia (CML) is characterised by the formation of the BCR/ABL fusion gene, usually as a result of the Philadelphia (Ph) translocation between chromosomes 9 and 22.
  • MATERIALS AND METHODS: The incidence of both typical and atypical BCR/ ABL gene rearrangements was determined in 110 patients suspected of CML using dual fusion fluorescence in situ hybridisation (DF-FISH) probes.
  • RESULTS: Eighty-seven per cent of CML patients showed Ph translocation while 13% were negative for the Ph chromosome.
  • About 71.9% of Ph-positive patients displayed the typical DF-FISH signal pattern.
  • Atypical patterns among the Ph-positive patients included the concurrent loss of residual proximal 9q and distal 22q (10.4%), complex translocation with additional partners (9.4%), supernumerary Ph (3.1%), loss of residual 9q sequences proximal to breakpoint (3.1%), and deletion of distal derivative 22q signal (2.1%).
  • Cryptic genetic alterations with loss of proximal 9q sequences were found in 13.5% of CML Ph-positive patients, which is associated with poor prognosis.
  • Fusion signals were detected in 57.1% of CML Ph-negative patients, indicating cryptic BCR/ABL rearrangements (i.e., masked Ph).
  • CONCLUSION: FISH is able to detect BCR/ABL fusion in CML with masked or variant Ph not apparent with conventional karyotyping.
  • Establishment of signal patterns with FISH is important as atypical patterns may have clinical prognostic implications.
  • [MeSH-major] Gene Rearrangement. Genes, abl / genetics. In Situ Hybridization, Fluorescence. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics

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  • (PMID = 16284673.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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37. Ernst T, Chase A, Zoi K, Waghorn K, Hidalgo-Curtis C, Score J, Jones A, Grand F, Reiter A, Hochhaus A, Cross NC: Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms. Haematologica; 2010 Sep;95(9):1473-80
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  • We hypothesized that hitherto unrecognized, cytogenetically cryptic tyrosine kinase fusions may be common in non-classical or atypical myeloproliferative neoplasms and related myelodysplastic/myeloproliferative neoplasms.
  • RESULTS: No abnormalities involving tyrosine kinases were detected; however, nine cytogenetically cryptic copy number imbalances were detected in seven patients, including hemizygous deletions of RUNX1 or CEBPA in two cases with atypical chronic myeloid leukemia.
  • Analysis of other transcription factors known to be frequently mutated in acute myeloid leukemia revealed NPM1 mutations in six (3%) and WT1 mutations in two (1%) patients with myelodysplastic/myeloproliferative neoplasms.
  • [MeSH-minor] CCAAT-Enhancer-Binding Proteins / genetics. Comparative Genomic Hybridization. DNA Mutational Analysis. Gene Dosage. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Myelopoiesis / genetics. Nuclear Proteins / genetics. Prognosis. WT1 Proteins / genetics


38. Takahashi W, Arai Y, Tadokoro J, Takeuchi K, Yamagata T, Mitani K: [Disappearance of a Philadelphia chromosome-positive clone and appearance of a -negative clone following treatment with imatinib mesylate in acute myelomonocytic leukemia]. Rinsho Ketsueki; 2006 Feb;47(2):111-4
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  • [Title] [Disappearance of a Philadelphia chromosome-positive clone and appearance of a -negative clone following treatment with imatinib mesylate in acute myelomonocytic leukemia].
  • A 63-year-old female was diagnosed as having Philadelphia chromosome-positive acute myelomonocytic leukemia in June 2002.
  • The patient received monotherapy with imatinib mesylate or combination therapy with DCM and idarubicin/cytarabine, both of which failed in attaining disease remission.
  • However, the second imatinib administration plus CAG therapy resulted in disappearance of the Philadelphia chromosome-positive clone and increase of Philadelphia chromosome-negative cells.
  • During a therapy-withholding period due to fungal infection, the Philadelphia chromosome-positive clone expanded and the patient died of cerebral hemorrhage in February 2003.
  • The transient suppression of the Philadelphia chromosome-positive clone may have brought about amplification of the Philadelphia chromosome-negative cells after the secondary imatinib treatment.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative. Leukemia, Myelomonocytic, Acute / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 16529013.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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39. Kannam HC, Satou G, Gandelman G, DeLuca AJ, Belkin R, Monsen C, Aronow WS, Peterson SJ, Krishnan U: Anomalous origin of the left main coronary artery from the right sinus of Valsalva with an intramural course identified by transesophageal echocardiography in a 14 year old with acute myocardial infarction. Cardiol Rev; 2005 Sep-Oct;13(5):219-22
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  • [Title] Anomalous origin of the left main coronary artery from the right sinus of Valsalva with an intramural course identified by transesophageal echocardiography in a 14 year old with acute myocardial infarction.
  • Coronary artery anomalies have an incidence of 0.6% to 1.3% in angiographic studies and 0.3% in an autopsy series.
  • Anomalous origin of the left main coronary artery (LMCA) from the right sinus of Valsalva (RSOV) represents a small fraction (1.3%) of these anomalies, with an overall prevalence of 0.017% to 0.03% in angiographic studies.
  • We present a case report of a 14-year-old patient with an LMCA arising from the RSOV with an initial intramural course, presenting with acute myocardial infarction (AMI) as the first indication of the anomaly.

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  • (PMID = 16106182.001).
  • [ISSN] 1061-5377
  • [Journal-full-title] Cardiology in review
  • [ISO-abbreviation] Cardiol Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cardiovascular Agents; 69PN84IO1A / Enalapril; GEB06NHM23 / Metoprolol; R16CO5Y76E / Aspirin
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40. Kim SW, Mintz GS, Ohlmann P, Hassani SE, Michalek A, Escolar E, Bui AB, Pichard AD, Satler LF, Kent KM, Suddath WO, Waksman R, Weissman NJ: Comparative intravascular ultrasound analysis of ostial disease in the left main versus the right coronary artery. J Invasive Cardiol; 2007 Sep;19(9):377-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative intravascular ultrasound analysis of ostial disease in the left main versus the right coronary artery.
  • BACKGROUND: Significant aorto-ostial disease is difficult to evaluate with angiography and sometimes even with intravascular ultrasound (IVUS).
  • METHODS: We used IVUS to compare ostial lesions in the left main coronary (LMCA, n = 45) versus the right coronary artery (RCA, n = 50).
  • Negative remodeling was defined as a remodeling index (lesion/distal reference arterial area) < 0.95.
  • RESULTS: Patient age was 66 +/- 11 years in the LMCA group and 66 +/- 11 years in the RCA group; 56% of the LMCA ostial lesions and 46% of RCA ostial lesions were in males, and 35% of the LMCA ostial lesions and 20% of the RCA ostial lesions were in diabetics.
  • With the exception of a smaller minimum lumen area (p < 0.0001) and distal reference plaque burden (p = 0.002) in ostial RCA lesions and a larger eccentricity index in ostial LMCA lesions (p = 0.001), both sites were remarkably similar.
  • Both ostial LMCA and RCA lesions were short, had modest amounts of calcium, had modest plaque burdens, but had a marked frequency of negative remodeling (84% in LMCA and 86% in RCA; p = 1.0).
  • CONCLUSION: IVUS morphometry is similar in ostial LMCA and RCA lesions; negative remodeling is the dominant contributor to lumen compromise in both locations.

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  • (PMID = 17827506.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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41. Fassa AA, Wagatsuma K, Higano ST, Mathew V, Barsness GW, Lennon RJ, Holmes DR Jr, Lerman A: Intravascular ultrasound-guided treatment for angiographically indeterminate left main coronary artery disease: a long-term follow-up study. J Am Coll Cardiol; 2005 Jan 18;45(2):204-11
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  • [Title] Intravascular ultrasound-guided treatment for angiographically indeterminate left main coronary artery disease: a long-term follow-up study.
  • OBJECTIVES: The purpose of this study was to evaluate the efficacy of an intravascular ultrasound (IVUS)-guided strategy for patients with angiographically indeterminate left main coronary artery (LMCA) disease.
  • BACKGROUND: The assessment of LMCA lesions using coronary angiography is often challenging; IVUS provides useful information for assessment of coronary disease.
  • METHODS: Intravascular ultrasound was performed on 121 patients with angiographically normal LMCAs to determine the lower range of normal minimum lumen area (MLA), defined as the mean - 2 SD.
  • We conducted IVUS studies on 214 patients with angiographically indeterminate LMCA lesions, and deferral of revascularization was recommended when the MLA was larger than this predetermined value.
  • RESULTS: The lower range of normal LMCA MLA was 7.5 mm(2).
  • Of the patients with angiographically indeterminate LMCAs, 83 (38.8%) had an MLA <7.5 mm(2), and 131 (61.2%) an MLA > or =7.5 mm(2).
  • Left main coronary artery revascularization was performed in 85.5% (71 of 83) of patients with an MLA <7.5 mm(2) and deferred in 86.9% (114 of 131) of patients with an MLA > or =7.5 mm(2).
  • Multivariate predictors of cardiac events were age, smoking, and number of non-LMCA vessels diseased.
  • CONCLUSIONS: Intravascular ultrasound is an accurate method to assess angiographically indeterminate lesions of the LMCA.
  • [MeSH-major] Coronary Artery Disease / therapy. Coronary Artery Disease / ultrasonography. Myocardial Revascularization. Ultrasonography, Interventional


42. Wu XM, Liu CP, Lin WC, Kao HL: Long-term outcome of percutaneous coronary intervention for unprotected left main coronary artery disease. Int J Cardiol; 2010 Feb 4;138(3):272-6
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  • [Title] Long-term outcome of percutaneous coronary intervention for unprotected left main coronary artery disease.
  • OBJECTIVES: The aim of this study is to evaluate the in-hospital, 30 day and long-term outcomes after percutaneous coronary intervention for unprotected left main coronary artery disease.
  • BACKGROUNDS: Left main coronary artery (LMCA) diseases stenosis is a strong indication for coronary artery bypass grafting (CABG).
  • With improved device technology, percutaneous coronary intervention (PCI) with drug-eluting stent (DES) stents had been recently advocated as an alternative procedure for the unprotected LMCA disease.
  • METHODS: Between January 2003 and February 2007, all unprotected LMCA PCI procedures were retrospectively collected.
  • RESULTS: Fifty five consecutive patients with >50% diameter stenosis of LMCA undergoing PCI were analyzed.
  • CONCLUSIONS: Our results showed that PCI with stenting was an acceptable treatment option for patients with LMCA stenosis.
  • Involvement of the LMCA bifurcation remains a predictor for unfavorable outcome.
  • [MeSH-major] Angioplasty, Balloon, Coronary / mortality. Coronary Artery Disease / mortality. Coronary Artery Disease / therapy. Drug-Eluting Stents / statistics & numerical data

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  • [Copyright] Copyright 2008 Elsevier Ireland Ltd. All rights reserved.
  • [CommentIn] Int J Cardiol. 2010 Sep 24;144(1):90-1 [19157586.001]
  • (PMID = 18804295.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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43. Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, Maruhashi T, Kagawa E, Dai K, Matsushita J, Ikenaga H: Electrocardiographic prediction of short-term prognosis in patients with acute myocardial infarction associated with the left main coronary artery. J Electrocardiol; 2009 Mar-Apr;42(2):106-10
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  • [Title] Electrocardiographic prediction of short-term prognosis in patients with acute myocardial infarction associated with the left main coronary artery.
  • PURPOSE: The purpose of this study was to assess the usefulness of electrocardiogram on admission to predict short-term prognosis in patients with acute myocardial infarction (AMI) associated with left main coronary artery (LMCA).
  • METHODS: Electrocardiogram was obtained on admission in 41 patients with AMI associated with LMCA who underwent reperfusion therapy.
  • Nonsurvivors had ST-segment elevation in both leads aVR and aVL (54% vs 18%, P < .05), left anterior fascicular block (83% vs 41%, P < .05), and right bundle-branch block (54% vs 18%, P < .05) more frequently, and ST-segment depression in lead V(5) (17% vs 59%, P < .05) less frequently than survivors among patients with AMI associated with LMCA.
  • CONCLUSIONS: Our data suggested that electrocardiogram on admission might be useful to predict short-term prognosis in patients with AMI associated with LMCA.
  • [MeSH-major] Coronary Artery Disease / diagnosis. Coronary Artery Disease / mortality. Electrocardiography / methods. Myocardial Infarction / diagnosis. Myocardial Infarction / mortality. Outcome Assessment (Health Care) / methods

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  • (PMID = 19084235.001).
  • [ISSN] 1532-8430
  • [Journal-full-title] Journal of electrocardiology
  • [ISO-abbreviation] J Electrocardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Barragan P, Fajadet J, Sheiban I, Serruys P, Colombo A, Seabra-Gomes R, Goy JJ, Cook S, Rubino P, Lefèvre T: Elective implantation of sirolimus-eluting stents for bifurcated and non-bifurcated unprotected left main coronary artery lesions: clinical outcomes at one year. EuroIntervention; 2008 Aug;4(2):262-70
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  • [Title] Elective implantation of sirolimus-eluting stents for bifurcated and non-bifurcated unprotected left main coronary artery lesions: clinical outcomes at one year.
  • AIMS: Recent studies of drug-eluting stents for unprotected left main coronary artery (LMCA) disease have been encouraging.
  • METHODS AND RESULTS: This retrospective study included 228 consecutive patients (mean age = 68 +/- 11 years, 80.6% men, 26.3% diabetics) who underwent implantation of SES for de novo LMCA stenoses.
  • The main objective of this study was to measure the rate of major adverse cardiac events (MACE), including death, myocardial infarction and target lesion revascularisation (TLR) at 12 months.
  • CONCLUSIONS: SES implants in high-risk patients with LMCA stenoses were associated with a low 1-year MACE rate.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Disease / therapy. Immunosuppressive Agents / administration & dosage. Sirolimus / administration & dosage

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  • (PMID = 19110793.001).
  • [ISSN] 1774-024X
  • [Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • [ISO-abbreviation] EuroIntervention
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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45. Qiu JY, Zhang Y, Lu DP, Lai YY, He Q, Shi Y: [Clinical and cytogenetical study on subacute myeloid leukemia in myelodysplastic syndromes]. Zhonghua Nei Ke Za Zhi; 2005 Jun;44(6):407-10
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  • [Title] [Clinical and cytogenetical study on subacute myeloid leukemia in myelodysplastic syndromes].
  • OBJECTIVE: To discuss from the clinical and cytogenetic aspect that part of patients now diagnosed as myelodysplastic syndromes (MDS) could be diagnosed early as leukemia and be classified as subacute myeloid leukemia (Sub-AML).
  • Among them 42 had +8 chromosome aberration, 16 had -7/7q-, and 55 had normal karyotypes and more than 0.10 blast cells in the bone marrow.
  • Short term culture and G-banding techniques and in some specimens fluorescence in situ hybridization (FISH) method were used to do chromosome analysis.
  • RESULTS: Among the detected chromosome aberrations, +8 was the most frequent (42.8%) and then -7/7q-(15.0%); 42 patients with +8 had median blast cell count of 0.08, within a median of 18 months follow-up period 40.0% of the patients evolved to frank leukemia (FL) and the median overall survival was 20 months.
  • CONCLUSIONS: Both the +8 and -7/7q- groups have malignant leukemic cell clone, and run a subacute and progressive clinical course; it is suggested they might be classified into Sub-AML.
  • [MeSH-major] Leukemia, Myeloid, Acute / genetics. Myelodysplastic Syndromes / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chromosome Aberrations. Cytogenetic Analysis. Female. Follow-Up Studies. Humans. Male. Middle Aged


46. Kelly JC, Shahbazi N, Scheerle J, Jahn J, Suchen S, Christacos NC, Mowrey PN, Witt MH, Hostetter A, Meloni-Ehrig AM: Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. Cancer Genet Cytogenet; 2009 Jul;192(1):36-9
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  • [Title] Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia.
  • We report a rare cryptic ins(12;9)(p13;q34q34), a chromosomal abnormality involving the ABL1 (9q34) and the ETV6 (alias TEL; 12p13) genes, detectable only by fluorescence in situ hybridization (FISH), in a patient with Philadelphia-negative chronic myeloid leukemia (CML).
  • Using reverse 4',6-diamidino-2-phenylindole banding on metaphase cells, FISH analysis with BCR/ABL dual-fusion and ETV6 break-apart probes showed that a third ABL signal was inserted into 12p, splitting the ETV6 signal into two adjacent signals.
  • CML patients with an ABL1/ETV6 fusion historically have demonstrated a variable and sometimes transient response to treatment with imatinib mesylate, which was also the case in the present patient.
  • [MeSH-major] Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 9. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Mutagenesis, Insertional. Oncogene Proteins, Fusion / genetics. Protein-Tyrosine Kinases / genetics


47. Giannoglou GD, Soulis JV, Farmakis TM, Giannakoulas GA, Parcharidis GE, Louridas GE: Wall pressure gradient in normal left coronary artery tree. Med Eng Phys; 2005 Jul;27(6):455-64
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  • [Title] Wall pressure gradient in normal left coronary artery tree.
  • The three-dimensional wall pressure gradient (WPG) of the normal human left coronary artery (LCA) tree is quantitatively analysed.
  • The LCA tree includes the left main coronary artery (LMCA), the left anterior descending (LAD), the left circumflex artery (LCxA) and their major branches.
  • [MeSH-minor] Animals. Computer Simulation. Coronary Artery Disease / physiopathology. Elasticity. Humans. Pressure. Reference Values. Stress, Mechanical

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  • (PMID = 15990062.001).
  • [ISSN] 1350-4533
  • [Journal-full-title] Medical engineering & physics
  • [ISO-abbreviation] Med Eng Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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48. Kim HS, Kim YH, Lee SW, Park DW, Lee CW, Hong MK, Kim JJ, Park SW, Park SJ: Safety and effectiveness of sirolimus-eluting stent implantation for in-stent restenosis of the unprotected left main coronary artery. Int J Cardiol; 2008 Feb 20;124(1):118-20
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  • [Title] Safety and effectiveness of sirolimus-eluting stent implantation for in-stent restenosis of the unprotected left main coronary artery.
  • The present study examined the alternative treatment of sirolimus-eluting stent (SES) implantation for in-stent restenosis (ISR) of the unprotected left main coronary artery (LMCA).
  • Twelve patients underwent SES deployment for bare-metal ISR in the LMCA.
  • ISR were 24+/-11 mm in length and located at the ostial (n=1) and distal (n=11) portion of LMCA.
  • Bifurcation lesions were treated with one of three techniques: the stent crossing the left circumflex artery (n=7), kissing stenting (n=2) or the Crush technique (n=2).
  • There were no cases of significant narrowing in the left circumflex artery after the procedure.
  • The present study suggests that SES implantation may be a feasible therapeutic option for treating ISR in unprotected LMCA.

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  • (PMID = 17383034.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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49. Murasato Y, Horiuchi M, Otsuji Y: Three-dimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography. Catheter Cardiovasc Interv; 2007 Aug 1;70(2):211-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three-dimensional modeling of double-stent techniques at the left main coronary artery bifurcation using micro-focus X-ray computed tomography.
  • BACKGROUND: Various double-stent techniques using drug-eluting stents have been proposed to treat the left main coronary artery (LMCA) bifurcation.
  • However, use of these techniques is frequently associated with focal restenosis at the ostium of the left circumflex coronary artery (LCX).
  • OBJECTIVES: To examine the results of double-stent techniques, using a silicon model of the LMCA bifurcation and three-dimensional (3D) reconstruction images created with micro-focus X-ray computed tomography (MFCT).
  • METHODS: Crush, kissing, and modified T stentings were performed with bare metal stents in a LMCA bifurcation model.
  • The stents were then inspected using MFCT at a minimal resolution of 0.06 mm.
  • RESULTS: Gaps in stent apposition to the vessel were observed at the site of stent overlap in the distal LMCA with all stenting techniques.
  • In crush stenting, when the left anterior descending artery stent overlapped the LCX stent, the latter was crushed on the myocardial side of the vessel, and a gap was observed on the nonmyocardial side, at the LCX ostium.
  • CONCLUSIONS: Close apposition of the stent to the vessel at the ostium of the LCX is difficult to achieve at the LMCA bifurcation, regardless of which double-stent technique is employed, due to the site's wide bifurcation angle and complex 3D structure.
  • [MeSH-major] Blood Vessel Prosthesis. Blood Vessel Prosthesis Implantation / instrumentation. Coronary Angiography / methods. Coronary Artery Disease / radiography. Imaging, Three-Dimensional. Radiographic Image Interpretation, Computer-Assisted. Stents. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17421017.001).
  • [ISSN] 1522-1946
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metals
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50. Murati A, Arnoulet C, Lafage-Pochitaloff M, Adélaide J, Derré M, Slama B, Delaval B, Popovici C, Vey N, Xerri L, Mozziconacci MJ, Boulat O, Sainty D, Birnbaum D, Chaffanet M: Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. Int J Oncol; 2005 Jun;26(6):1485-92
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  • [Title] Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion.
  • The case of a patient presenting with a myeloproliferative disorder (MPD) characterized by a t(8;22) (p12;q11) translocation was investigated.
  • The rearrangement resulted in the production of BCR-FGFR1 and FGFR1-BCR chimeric transcripts after in-frame fusions of BCR exon 4 with FGFR1 exon 9 and FGFR1 exon 8 with BCR exon 5, respectively.
  • The four previously reported patients with such translocation presented with an atypical chronic myeloid leukemia (CML) without Philadelphia chromosome.
  • The BCR-FGFR1 gene fusion was detected by dual-color fluorescence in situ hybridization in both CD19- and CD19+ populations.
  • In contrast to the other FGFR1-MPDs that show myeloid and T cell proliferation, we propose that this t(8;22) MPD is a myeloid and B cell disease, and potentially a novel type of hematological disease.
  • [MeSH-minor] Aged. Chromosomes, Human, Pair 22. Humans. Immunophenotyping. Male. Proto-Oncogene Proteins c-bcr. Receptor, Fibroblast Growth Factor, Type 1

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  • (PMID = 15870860.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Receptors, Fibroblast Growth Factor; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.11.1 / BCR protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr
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51. Soleimani A, Abbasi A, Kazzazi EH, Hosseini K, Salirifar M, Darabian S, Sadeghian S, Sheikhfathol-Lahi M: Prevalence of left main coronary artery disease among patients with ischemic heart disease: insights from the Tehran Angiography Registry. Minerva Cardioangiol; 2009 Apr;57(2):175-83
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  • [Title] Prevalence of left main coronary artery disease among patients with ischemic heart disease: insights from the Tehran Angiography Registry.
  • AIM: This study was designed to investigate the prevalence of left main coronary artery (LMCA) significant stenosis among patients with stable angina (SA) or acute coronary syndromes (ACSs) and to assess the influence of demographic and clinical profiles on these findings.
  • The patients' characteristics were compared in subgroups with and without LMCA disease.
  • RESULTS: Significant and minimal LMCA stenoses were found in 659 (3.6%) and 1157 (6.4%) patients, respectively.
  • An unprotected LMCA disease was estimated in 609 (3.4%) subjects.
  • A cumulative Logit Model analysis revealed the male gender (odds ratio [OR]=1.480, 95% confidence interval [CI]=1.287 to 1.703; P<0.001), diabetes mellitus (OR=1.158, 95% CI=1.029 to 1.303; P=0.015), dyslipidemia (OR=1.125, 95% CI=1.001 to 1.265; P=0.048), and aging (OR=1.028, 95% CI=1.022 to 1.034; P<0.001) as the independent predictors of LMCA stenosis with coexistent diseases in the rest of the coronary arteries.
  • In the patients with normal or minimal stenoses of the other coronary arteries, cigarette smoking (OR=3.749, 95% CI=1.698 to 8.070) was found to be the independent risk factor of isolated LMCA disease.
  • Luminal stenosis >50% in the right coronary artery, the left circumflex artery, and the left anterior descending artery was significantly more frequent in association with LMCA disease.
  • CONCLUSIONS: The patients with LMCA disease were more likely to be male, older, and have diabetes mellitus or dyslipidemia, whereas cigarette smoking was found as an independent predictor of isolated LMCA.
  • There was a strong correlation between the severity of LMCA stenosis and coexistent diseases in the rest of the coronary arteries.
  • [MeSH-major] Coronary Artery Disease / epidemiology. Medical Records / statistics & numerical data. Myocardial Ischemia / complications

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  • (PMID = 19274028.001).
  • [ISSN] 0026-4725
  • [Journal-full-title] Minerva cardioangiologica
  • [ISO-abbreviation] Minerva Cardioangiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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52. Han Y, Wang S, Jing Q, Li Y, Liu H, Ma Y, Wang Z, Wang D, Luan B, Wang G, Chen T: Comparison of long-term efficacy of the paclitaxel-eluting stent versus the bare-metal stent for treatment of unprotected left main coronary artery disease. Am J Cardiol; 2009 Jan 15;103(2):194-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of long-term efficacy of the paclitaxel-eluting stent versus the bare-metal stent for treatment of unprotected left main coronary artery disease.
  • The use of paclitaxel-eluting stents (PES) for the treatment of unprotected left main coronary artery (LMCA) disease is controversial.
  • Between January 2003 and December 2006, a total of 287 patients undergoing percutaneous coronary intervention for LMCA lesions were consecutively registered.
  • PES recipients had distal left main bifurcation lesions more frequently compared with BMS recipients (72 vs 42%, p<0.01).
  • In conclusion, PES implantation provides a safe, effective therapy for unprotected LMCA disease and decreases the risk of major adverse cardiac events compared with BMS at a mean follow-up of 35 months.
  • [MeSH-major] Coronary Artery Disease / therapy. Drug-Eluting Stents. Paclitaxel / administration & dosage. Stents. Tubulin Modulators / administration & dosage

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  • (PMID = 19121435.001).
  • [ISSN] 1879-1913
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel
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53. Wong D, Golding F, Hess L, Caldarone CA, Van Arsdell G, Manlhiot C, McCrindle BW, Miner SE, Nield LE: Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation. Am Heart J; 2008 Sep;156(3):466-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation.
  • BACKGROUND: Arterial switch operation is standard repair for complete transposition of the great arteries (TGA).
  • Coronary artery abnormalities are the most common cause of morbidity and mortality in the acute postoperative phase.
  • This study was designed to determine whether coronary artery pulse Doppler flow patterns obtained by transesophageal echocardiography during the arterial switch operation are correlated with acute postoperative outcomes.
  • Intraoperative coronary artery pulse Doppler flow patterns were analyzed by 2 blinded investigators.
  • Associations of coronary artery pulse Doppler flow patterns with clinical outcomes were sought using multivariable linear and logistic regression analysis.
  • The most common coronary artery pulse Doppler flow pattern consisted of a late systolic peak followed by low-velocity flow throughout diastole.
  • A left main coronary artery (LMCA) velocity time integral >0.14 (P = .01) and an LMCA peak systolic velocity >0.6 cm/s (P = .05) were associated with need for surgical revision.
  • CONCLUSION: Abnormalities in LMCA flow were associated with the need for surgical revision in patients with TGA undergoing the arterial switch operation.
  • Normal coronary artery pulse Doppler flow patterns after the arterial switch operation consisted of a late systolic peak followed by low-velocity flow throughout diastole.

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  • (PMID = 18760127.001).
  • [ISSN] 1097-6744
  • [Journal-full-title] American heart journal
  • [ISO-abbreviation] Am. Heart J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Lee BK, Hong MK, Lee CW, Choi BR, Kim MJ, Park KH, Kim YH, Han KH, Kim JJ, Park SW, Park SJ: Five-year outcomes after stenting of unprotected left main coronary artery stenosis in patients with normal left ventricular function. Int J Cardiol; 2007 Feb 7;115(2):208-13
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  • [Title] Five-year outcomes after stenting of unprotected left main coronary artery stenosis in patients with normal left ventricular function.
  • BACKGROUND: We analyzed the long-term (5-year) outcome of patients treated with stenting for unprotected left main coronary artery (LMCA) stenosis.
  • METHODS: Between January 1995 and September 2001, 187 consecutive patients with unprotected LMCA stenosis and normal left ventricular function underwent elective stenting.
  • At 1, 3 and 5 years, the cumulative probabilities for freedom from MACE were 79.9+/-1.8%, 77.5+/-2.5% and 77.5+/-2.5%, respectively.
  • CONCLUSION: The initial favorable outcomes of patients with normal left ventricular function after stenting of unprotected LMCA stenosis were sustained for up to 5 years.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Stenosis / therapy. Stents. Ventricular Function, Left

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  • (PMID = 16904209.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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55. Noestelthaller A, Probst A, König HE: Branching patterns of the left main coronary artery in the dog demonstrated by the use of corrosion casting technique. Anat Histol Embryol; 2007 Feb;36(1):33-7
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  • [Title] Branching patterns of the left main coronary artery in the dog demonstrated by the use of corrosion casting technique.
  • As many investigators use dogs as experimental models in catheterization-, ligation-, and collateral flow studies, knowledge and awareness of the canine left coronary artery anatomical variation is vital for differentiation between canine and human coronary arterial patterns and canine and human coronary congenital anomalies with or without circulatory importance.
  • The present study was performed to examine and review the various principal subdivisions of the canine left main coronary artery (LMCA) in vascular casts of 20 hearts obtained from cadavers of clinically normal dogs of various ages, breeds and of either sex.
  • A corrosion casting technique using an acrylic resin called Tensol Cement No. 70 and a lower-viscosity acrylic resin called Mercox were used to produce a three-dimensional model of the canine coronary arteries.
  • In our study, all dog hearts were left preponderant and the patterns of the principal subdivisions of the LMCA were grouped into three types: Type 1 occurred in seven of the 20 dogs (35%), Type 2 in 12 of 20 dogs (60%) and Type 3 in one instance (5%).
  • A comparison between the canine divisional patterns of the LMCA in the vascular casts and those reported in the literature showed major agreement.

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  • (PMID = 17266665.001).
  • [ISSN] 0340-2096
  • [Journal-full-title] Anatomia, histologia, embryologia
  • [ISO-abbreviation] Anat Histol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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56. Gianelli U, Vener C, Raviele PR, Savi F, Somalvico F, Calori R, Iurlo A, Radaelli F, Fermo E, Bucciarelli P, Bori S, Coggi G, Deliliers GL: VEGF expression correlates with microvessel density in Philadelphia chromosome-negative chronic myeloproliferative disorders. Am J Clin Pathol; 2007 Dec;128(6):966-73
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  • [Title] VEGF expression correlates with microvessel density in Philadelphia chromosome-negative chronic myeloproliferative disorders.
  • We examined microvessel density (MVD) and immunohistochemical expression of vascular endothelial growth factor (VEGF) in the bone marrow biopsy specimens of 98 patients with Philadelphia chromosome-negative (Ph-) chronic myeloproliferative disorders (CMPDs).
  • There were significantly more MVD "hot spots" in chronic idiopathic myelofibrosis (CIMF; mean +/- SD, 25.6 +/- 6.3) and polycythemia vera (PV; 20.7 +/- 10.2) cases than in essential thrombocythemia (ET) cases (10.1 +/- 4.5) and normal control (NC) samples (7.5 +/- 3.6) (P < .05).
  • There was a direct correlation between VEGF(i) and MVD when considering the Ph- CMPDs together (r = 0.67; P < .001) and when considering PV (r = 0.79; P < .001) and CIMF (r = 0.40; P = .013) as individual entities.
  • [MeSH-major] Bone Marrow / pathology. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / metabolism. Neovascularization, Pathologic / metabolism. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Chronic Disease. DNA Mutational Analysis. Female. Humans. Male. Microcirculation / metabolism. Microcirculation / pathology. Middle Aged

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  • (PMID = 18024322.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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57. Bitigen A, Karavelioglu Y, Kaynak E, Yilmaz MB: A case of myocardial infarction due to acute left main coronary artery occlusion presenting with peculiar electrocardiographic changes. Int J Cardiovasc Imaging; 2006 Jun-Aug;22(3-4):343-7
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  • [Title] A case of myocardial infarction due to acute left main coronary artery occlusion presenting with peculiar electrocardiographic changes.
  • Myocardial infarction (MI) due to acute obstruction of the left main coronary artery (LMCA) occlusion is a medical emergency, requiring early and prompt diagnosis and revascularization, and unless it is treated, it will frequently result in cardiogenic shock, which has a high fatality rate.
  • ECG is the easiest diagnostic method in the early diagnosis of the acute coronary syndromes and in deciding on the early invasive intervention in the high risk group.
  • At the time of the urgent coronary angiography, it was noticed that the LMCA was totally occluded.
  • This case has been presented in order to emphasize that peculiar changes might bring about devastating consequences as in our rare case, showing acute left main coronary artery occlusion, and ST segment elevation only in the AVR on the 12-lead ECG along with upward deflection of ST segment vector might be critical for accurate diagnosis.

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  • [Cites] J Am Coll Cardiol. 2001 Nov 1;38(5):1348-54 [11691506.001]
  • [Cites] N Engl J Med. 1999 Aug 26;341(9):625-34 [10460813.001]
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  • (PMID = 16518669.001).
  • [ISSN] 1569-5794
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Parodi G, Maehara A, Giuliani G, Kubo T, Mintz GS, Migliorini A, Valenti R, Carrabba N, Antoniucci D: Optical coherence tomography in unprotected left main coronary artery stenting. EuroIntervention; 2010 May;6(1):94-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optical coherence tomography in unprotected left main coronary artery stenting.
  • AIMS: Delayed or incomplete stent endothelisation and stent malapposition may predispose to DES thrombosis that can be a catastrophic event in the left main coronary artery (LMCA).
  • OCT can accurately identify stent struts and arterial tissue, but is limited by the need of vessel blood clearance and penetration; also no data exist on its use in LMCA.
  • We sought to verify whether optical coherence tomography (OCT) can accurately assess arterial wall response after drug eluting stent (DES) implantation in the LMCA.
  • METHODS AND RESULTS: OCT images were obtained in 15 patients (mean age 70.7 + or - 8.0 years) six months after LMCA DES implantation.
  • Acquisitions were performed without proximal balloon occlusion during isoosmolar contrast injection through a 6 Fr guiding catheter without side holes at a speed of 2-3 mL/sec.
  • In five patients OCT detected abnormal intraluminal tissue, and in two cases this finding was related to uncovered struts.
  • CONCLUSIONS: OCT assessment of vascular response after LMCA DES implantation is safe and feasible.
  • Further development of OCT imaging technology will be necessary for complete evaluation of LMCA stents.
  • [MeSH-major] Angioplasty, Balloon, Coronary / instrumentation. Coronary Artery Disease / therapy. Coronary Vessels / pathology. Drug-Eluting Stents. Tomography, Optical Coherence

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  • (PMID = 20542803.001).
  • [ISSN] 1969-6213
  • [Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • [ISO-abbreviation] EuroIntervention
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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59. Crnovcić I, Süssmuth R, Keller U: Aromatic C-methyltransferases with antipodal stereoselectivity for structurally diverse phenolic amino acids catalyze the methylation step in the biosynthesis of the actinomycin chromophore. Biochemistry; 2010 Nov 16;49(45):9698-705
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  • The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus harbors two paralogous genes, acmI and acmL, encoding methyltransferases.
  • AcmI and AcmL methylate also hydroxyphenyl-amino propanoic acids such as p-tyrosine, m-tyrosine, or 3,4-dihydroxy-l-phenylalanine (DOPA) but at a lower rate than 3-HK.
  • AcmI and AcmL show sequence similarity to various C- and O-methyltransferases from bacteria.
  • Remarkably, computational remodelling of AcmI and AcmL structures revealed significant similarity with the 3-D structures of type 1 O-methyltransferases from plants such as caffeic acid O-methyltransferase (COMT) and other phenylpropanoid methyltransferases.

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  • (PMID = 20945860.001).
  • [ISSN] 1520-4995
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / DNA Primers; 0 / DNA, Bacterial; 0 / Phenols; 1CC1JFE158 / Dactinomycin; 343-65-7 / Kynurenine; 42HK56048U / Tyrosine; EC 2.1.1.- / Methyltransferases
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60. Suzuki T, Asai T, Matsubayashi K, Kambara A, Hiramatsu N, Kinoshita T, Nishimura O: Left main coronary artery disease does not affect the outcome of off-pump coronary artery bypass grafting. Ann Thorac Surg; 2010 Nov;90(5):1501-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Left main coronary artery disease does not affect the outcome of off-pump coronary artery bypass grafting.
  • BACKGROUND: Left main coronary artery (LMCA) stenosis (≥50%) has historically been recognized as a risk factor among patients undergoing coronary artery bypass grafting.
  • METHODS: From January 2002 to December 2008, a total of 665 patients, 268 of whom had significant LMCA disease, underwent isolated off-pump coronary artery bypass surgery at Shiga Medical University Hospital.
  • We compared the clinical results in the 237 patients with LMCA stenosis (LMCA group) with those in the propensity score-matched 237 patients without LMCA stenosis (non-LMCA group).
  • We performed off-pump surgery in all coronary artery bypass grafting cases with no exclusion criteria.
  • Two patients in the LMCA group (2 of 237; 0.8%) and four in the non-LMCA group (4 of 237; 1.7%) died within 30 days after surgery.
  • The rates of six-year freedom from all cause death were 87.3% and 60.7% in the LMCA group and non-LMCA group, respectively (p = 0.17), and the corresponding rates for the combined endpoint of cardiac death, myocardial infarction, angina pectoris, repeat coronary intervention, and heart failure were 80.4% and 70.4% (p = 0.98).
  • Multivariate Cox regression analysis revealed chronic renal failure as a statistically significant predictor for late cardiac event.
  • CONCLUSIONS: Off-pump coronary artery bypass grafting is feasible and safe in patients with critical LMCA stenosis and LMCA disease is not recognized as a risk factor after off-pump coronary artery bypass grafting in either the short or the long term.
  • [MeSH-major] Coronary Artery Bypass, Off-Pump / adverse effects. Coronary Stenosis / complications
  • [MeSH-minor] Aged. Female. Humans. Kidney Failure, Chronic / etiology. Male. Middle Aged. Proportional Hazards Models. Treatment Outcome

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2010 Nov;90(5):1506 [20971249.001]
  • (PMID = 20971248.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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61. Verstovsek S: Preclinical and clinical experience with dasatinib in Philadelphia chromosome-negative leukemias and myeloid disorders. Leuk Res; 2009 May;33(5):617-23
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  • [Title] Preclinical and clinical experience with dasatinib in Philadelphia chromosome-negative leukemias and myeloid disorders.
  • Recent advances in the molecular characterization of Philadelphia chromosome-negative (Ph-) leukemias and related myeloid disorders have provided a clear rationale for investigating novel targeted therapies.
  • Dasatinib is a tyrosine kinase inhibitor with activity against BCR-ABL, platelet-derived growth factor receptors (PDGFRs), c- KIT, fibroblast growth factor receptors (FGFRs), SRC family kinases (SFKs), and EPHA receptors, all of which have been implicated in the pathogenesis of Ph- leukemias and myeloid disorders.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Pyrimidines / therapeutic use. Thiazoles / therapeutic use

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  • (PMID = 19013641.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Pyrimidines; 0 / Thiazoles; RBZ1571X5H / Dasatinib
  • [Number-of-references] 49
  • [Other-IDs] NLM/ NIHMS684515; NLM/ PMC4428150
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62. Kim U, Park JS, Seol SH, Yang TH, Kim SM, Kim DK, Kim DI, Kim DS, Lee WJ, Lee SH, Hong GR, Shin DG, Kim YJ, Shim BS, Cho YK, Kim HS, Nam CW, Hur SH, Kim KB, Kim YN: Two-year outcomes of the sirolimus-eluting stent according to unprotected left main lesion. Clin Cardiol; 2009 Jun;32(6):332-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two-year outcomes of the sirolimus-eluting stent according to unprotected left main lesion.
  • BACKGROUND: The data of long-term outcomes of sirolimus-eluting stent (SES) according to lesion location of unprotected left main coronary artery (LMCA) is scarce.
  • HYPOTHESIS: The purpose of this study was to evaluate the long-term outcomes after implantation of the SES in LMCA.
  • METHODS: A total of 84 patients (51 males) who had undergone SES implantation for the treatment of native LMCA stenosis were enrolled.
  • Although angiographic success and in-hospital MACE rates were similar in both groups with 1 cardiac death due to acute stent thrombosis in group 2, at 2-year follow-up, the MACE rate was significantly higher in group 2 than in group 1 at 2 years (22.2% vs 2.6%, respectively, P = 0.008).
  • CONCLUSIONS: Interventional treatment using SES in left main lesions showed favorable short-term and long-term outcomes in selected patients with lesion location being an important determinant of clinical and angiographic outcomes.

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  • [Copyright] 2009 Wiley Periodicals, Inc.
  • (PMID = 19569064.001).
  • [ISSN] 1932-8737
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cardiovascular Agents; W36ZG6FT64 / Sirolimus
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63. Kim YH, Dangas GD, Solinas E, Aoki J, Parise H, Kimura M, Franklin-Bond T, Dasgupta NK, Kirtane AJ, Moussa I, Lansky AJ, Collins M, Stone GW, Leon MB, Moses JW, Mehran R: Effectiveness of drug-eluting stent implantation for patients with unprotected left main coronary artery stenosis. Am J Cardiol; 2008 Mar 15;101(6):801-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of drug-eluting stent implantation for patients with unprotected left main coronary artery stenosis.
  • This study was aimed to evaluate outcomes of patients with unprotected left main coronary artery (LMCA) stenosis who were treated with drug-eluting stents.
  • Sixty-three consecutive patients with unprotected LMCA stenosis were treated with sirolimus-eluting stents in 52 (83%) patients and paclitaxel-eluting stents in 11 (17%) patients, in whom percutaneous intervention was considered the sole alternative because of high surgical risk and/or patient preference.
  • Involvement of the distal LMCA was observed in 46 (73%) patients.
  • In conclusion, drug-eluting stent placement for unprotected LMCA stenosis may be a feasible therapeutic alternative in patients at high surgical risk.

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  • (PMID = 18328844.001).
  • [ISSN] 0002-9149
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible; 0 / Immunosuppressive Agents; 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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64. Namboodiri N, Ajitkumar V, Tharakan J: A rare type of dual left anterior descending artery distribution demonstrated by multislice cardiac computerized tomography in a patient with anterior wall infarction. J Invasive Cardiol; 2008 Jul;20(7):367-9
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  • [Title] A rare type of dual left anterior descending artery distribution demonstrated by multislice cardiac computerized tomography in a patient with anterior wall infarction.
  • Dual left anterior descending coronary artery (LAD) distribution with either of the vessels originating from the left main coronary artery (LMCA) and the right aortic sinus of Valsalva is an extremely rare coronary artery anomaly.
  • Here we discuss a 45-year-old male who presented with non-ST-elevation anterior wall myocardial infarction due to near-total occlusion of the LAD immediately after its origin from the LMCA.

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  • (PMID = 18599898.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Wu J, Meng F, Kong LY, Peng Z, Ying Y, Bornmann WG, Darnay BG, Lamothe B, Sun H, Talpaz M, Donato NJ: Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst; 2008 Jul 2;100(13):926-39
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  • [Title] Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.
  • BACKGROUND: Imatinib is a tyrosine kinase inhibitor that is used to treat chronic myelogenous leukemia (CML).
  • BCR-ABL mutations are associated with failure of imatinib treatment in many CML patients.
  • LYN kinase regulates survival and responsiveness of CML cells to inhibition of BCR-ABL kinase, and differences in LYN regulation have been found between imatinib-sensitive and -resistant CML cell lines.
  • METHODS: We evaluated cells from 12 imatinib-resistant CML patients with mutation-negative BCR-ABL and from six imatinib-sensitive patients who discontinued therapy because of imatinib intolerance.
  • Phosphorylation of BCR-ABL and LYN was assessed in patient cells and cell lines by immunoblotting with activation state-specific antibodies, co-immunoprecipitation studies, and mass spectroscopy analysis of phosphopeptides.
  • RESULTS: Imatinib treatment suppressed LYN phosphorylation in cells from imatinib-sensitive CML patients and imatinib-sensitive cell lines.
  • Imatinib treatment blocked BCR-ABL signaling but did not suppress LYN phosphorylation in cells from imatinib-resistant patients, and persistent activation of LYN kinase was not associated with mutations in LYN kinase or its carboxyl-terminal regulatory domains.
  • Reducing LYN expression (siRNA) or activation (dasatinib) was associated with loss of cell survival and cytogenetic or complete hematologic responses in imatinib-resistant disease.
  • CONCLUSIONS: LYN activation was independent of BCR-ABL in cells from imatinib-resistant patients.
  • Thus, LYN kinase may be involved in imatinib resistance in CML patients with mutation-negative BCR-ABL and its direct inhibition is consistent with clinical responses in these patients.

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  • (PMID = 18577747.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA49639
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Fusion Proteins, bcr-abl; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases; EC 3.4.22.- / Caspases
  • [Other-IDs] NLM/ PMC2902818
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66. Kim YH, Park SW, Hong MK, Park DW, Park KM, Lee BK, Song JM, Han KH, Lee CW, Kang DH, Song JK, Kim JJ, Park SJ: Comparison of simple and complex stenting techniques in the treatment of unprotected left main coronary artery bifurcation stenosis. Am J Cardiol; 2006 Jun 1;97(11):1597-601
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  • [Title] Comparison of simple and complex stenting techniques in the treatment of unprotected left main coronary artery bifurcation stenosis.
  • We assessed the safety and feasibility of various stenting techniques using the sirolimus-eluting stent (SES) in the treatment of unprotected left main coronary artery (LMCA) bifurcation stenoses.
  • One hundred sixteen patients with unprotected LMCA bifurcation stenoses underwent SES implantation.
  • A simple stenting technique (simple group, n = 67) across the left circumflex artery (LCx) and a complex technique (complex group) comprising "kissing" stenting (n = 24) or a "crush" (n = 25) technique were used.
  • In conclusion, SES implantation for unprotected LMCA bifurcation stenoses appears to be safe and effective.

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  • (PMID = 16728221.001).
  • [ISSN] 0002-9149
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Randi ML, Ruzzon E, Luzzatto G, Tezza F, Girolami A, Fabris F: Safety profile of hydroxyurea in the treatment of patients with Philadelphia-negative chronic myeloproliferative disorders. Haematologica; 2005 Feb;90(2):261-2
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  • [Title] Safety profile of hydroxyurea in the treatment of patients with Philadelphia-negative chronic myeloproliferative disorders.
  • [MeSH-major] Hydroxyurea / pharmacology. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Polycythemia Vera / drug therapy. Thrombocytosis / drug therapy


68. Tsupryk A, Gorbovitski M, Kabotyanski EA, Gorfinkel V: Novel design of multicapillary arrays for high-throughput DNA sequencing. Electrophoresis; 2006 Jul;27(14):2869-79
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  • A novel approach to design and optimize linear multicapillary arrays (LMCAs) for high-throughput DNA sequencing is proposed.
  • Theoretical and experimental studies showed that in conjunction with a dual-side laser illumination scheme, the proposed LMCA design allows a simultaneous uniform irradiation of as many as 550 working capillaries.

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  • (PMID = 16800025.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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69. Lee RJ, Shih KN, Lee SH, Shyu KG, Chiu CZ, Lin SC, Hung HF, Liou JY, Cheng JJ, Kuan P: Predictors of long-term outcomes in patients after elective stent implantation for unprotected left main coronary artery disease. Heart Vessels; 2007 Mar;22(2):99-103
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  • [Title] Predictors of long-term outcomes in patients after elective stent implantation for unprotected left main coronary artery disease.
  • The purpose of this study was to investigate the predictor of long-term outcomes in patients after stent implantation for unprotected left main coronary artery (LMCA) disease.
  • Coronary stenting has recently been advocated as an alternative procedure for LMCA disease.
  • Information on the predictors of long-term outcomes in patients after stent implantation for unprotected LMCA disease is not clear.
  • Seventy six patients (51 men and 25 women, age 68 +/- 10 years) with medically refractory angina received coronary stenting for unprotected LMCA disease.
  • During a follow-up period of 40 +/- 26 months, 7 patients (9%) died because of cardiovascular disease in 5 (7%) and noncardiovascular disease in 2 (3%).
  • In the other 69 patients, 19 patients (25%) needed repeated percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG).
  • A history of cerebral vascular attack (CVA) (P = 0.005), anemia (P = 0.03) and lower left ventricular ejection fraction (LVEF) (P = 0.008) were related to the cardiovascular mortality.
  • Female sex and young age could predict the repeated PCI and/or CABG in patients after stent implantation for unprotected LMCA disease.
  • [MeSH-major] Coronary Artery Disease / therapy. Stents
  • [MeSH-minor] Age Factors. Aged. Analysis of Variance. Angioplasty, Balloon, Coronary. Coronary Artery Bypass. Coronary Restenosis / therapy. Female. Humans. Male. Middle Aged. Prognosis. Retreatment. Risk Factors. Sex Factors. Stroke Volume. Treatment Outcome

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  • (PMID = 17390204.001).
  • [ISSN] 0910-8327
  • [Journal-full-title] Heart and vessels
  • [ISO-abbreviation] Heart Vessels
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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70. Carrié D, Lhermusier T, Hmem M, Maupas E, Elbaz M, Puel J: Clinical and angiographic outcome of paclitaxel-eluting stent implantation for unprotected left main coronary artery bifurcation narrowing. EuroIntervention; 2006 Feb;1(4):396-402
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  • [Title] Clinical and angiographic outcome of paclitaxel-eluting stent implantation for unprotected left main coronary artery bifurcation narrowing.
  • AIMS: This study was designed to compare the clinical and angiographic outcomes of paclitaxel-eluting stent (PES) and bare metal stent (BMS) implantation for unprotected left main coronary artery (LMCA) bifurcation narrowing.
  • METHODS AND RESULTS: From November 2003 to December 2004, the technique of kissing balloon followed by T provisional stenting was applied for distal left main coronary lesion in 49 consecutive patients with PES stents.
  • CONCLUSION: Paclitaxel-eluting stent implantation for unprotected LMCA bifurcation narrowing appears safe with regard to acute and midterm complications and is more effective in preventing restenosis compared to BMS implantation.

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  • (PMID = 19755213.001).
  • [ISSN] 1774-024X
  • [Journal-full-title] EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • [ISO-abbreviation] EuroIntervention
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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71. Olivieri L, Arling B, Friberg M, Sable C: Coronary artery Z score regression equations and calculators derived from a large heterogeneous population of children undergoing echocardiography. J Am Soc Echocardiogr; 2009 Feb;22(2):159-64
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  • [Title] Coronary artery Z score regression equations and calculators derived from a large heterogeneous population of children undergoing echocardiography.
  • BACKGROUND: Clinical decision making in Kawasaki disease relies on measurements of the coronary arteries obtained by 2-dimensional echocardiography.
  • Z scores relating measured values to independent variables are invaluable in ensuring the accurate and consistent treatment of patients with Kawasaki disease.
  • METHODS: The right coronary artery (RCA), left main coronary artery (LMCA), and left anterior descending (LAD) coronary artery were measured in 432 normal digital echocardiograms from a heterogeneous population of normal subjects aged 0 to 20 years.
  • RESULTS: Using the model ln(measurement) = beta(1) + beta(2) x ln(BSA), the adjusted R(2) values were 0.638, 0.702, and 0.708 for the RCA, LMCA, and LAD coronary artery models, respectively, with mean square error < 0.0402.
  • CONCLUSION: The calculation of accurate Z scores for coronary artery measurements in children can be accomplished using the Z-score calculator.

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  • (PMID = 19084373.001).
  • [ISSN] 1097-6795
  • [Journal-full-title] Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
  • [ISO-abbreviation] J Am Soc Echocardiogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Bock O, Hussein K, Kreipe H: Stem cell defects in Philadelphia chromosome negative chronic myeloproliferative disorders: a phenotypic and molecular puzzle? Curr Stem Cell Res Ther; 2007 Sep;2(3):253-63
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  • [Title] Stem cell defects in Philadelphia chromosome negative chronic myeloproliferative disorders: a phenotypic and molecular puzzle?
  • Philadelphia chromosome-negative chronic myeloproliferative disorders (Ph(-) CMPD) comprise a group of heterogenous haematological stem cell disorders.
  • By clonal evolution, acute leukaemia or bone marrow fibrosis evolve in a proportion of cases with as yet unknown underlying mechanisms.
  • Previously, groundbreaking investigations in Ph(-) CMPD detected an acquired mutation in the Janus kinase 2 (JAK2) in the majority of patients with polycythaemia vera (PV) and in up to 50% of patients with essential thrombocythaemia (ET) and chronic idiopathic myelofibrosis (CIMF).
  • Unlike the stem cell defect in Philadelphia chromosome-positive chronic myeloid leukaemia only a subfraction of clonally proliferating haematopoiesis may be affected by the JAK2 mutation.
  • In accordance with the uncontrolled Abl kinase activity in Ph(+) chronic myloid leukaemia these mutations in Ph(-) CMPD apparently represent a key to unlock some of the as yet unknown basic molecular defects and this raises hope for an upcoming efficient targeted therapy.
  • This review will focus on previous and recent findings in the field of molecular defects in Ph(-) CMPD.
  • [MeSH-major] Hematopoietic Stem Cells / physiology. Janus Kinase 2 / metabolism. Leukemia, Myeloid, Acute / physiopathology. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / physiopathology. Myeloproliferative Disorders / physiopathology
  • [MeSH-minor] Chromosome Aberrations. Cytokines / metabolism. Hematopoiesis. Humans. Mutation. Philadelphia Chromosome. Receptors, Thrombopoietin / metabolism. Thrombopoietin / metabolism


73. Zámecníkova A, Al Bahar S, Ramesh P: Trisomy 6 in a CML patient receiving imatinib mesylate therapy. Leuk Res; 2008 Sep;32(9):1454-7
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  • [Title] Trisomy 6 in a CML patient receiving imatinib mesylate therapy.
  • The emergence of chromosome abnormalities in Philadelphia-negative cells in chronic myelogenous leukemia patients during imatinib therapy have been described by several authors.
  • We describe a patient with Philadelphia chromosome-positive chronic myelogenous leukemia diagnosed in 1998, in whom multiple clonal abnormalities were identified in Ph-negative cells while on imatinib therapy.
  • The patient developed lymphoid blast crisis associated with an additional Ph chromosome and trisomy 6 in Ph-negative cells.
  • [MeSH-major] Chromosomes, Human, Pair 6 / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Piperazines / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Pyrimidines / therapeutic use. Trisomy

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  • (PMID = 18294688.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Protein Kinase Inhibitors; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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74. Park DW, Seung KB, Kim YH, Lee JY, Kim WJ, Kang SJ, Lee SW, Lee CW, Park SW, Yun SC, Gwon HC, Jeong MH, Jang YS, Kim HS, Kim PJ, Seong IW, Park HS, Ahn T, Chae IH, Tahk SJ, Chung WS, Park SJ: Long-term safety and efficacy of stenting versus coronary artery bypass grafting for unprotected left main coronary artery disease: 5-year results from the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) registry. J Am Coll Cardiol; 2010 Jul 6;56(2):117-24
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  • [Title] Long-term safety and efficacy of stenting versus coronary artery bypass grafting for unprotected left main coronary artery disease: 5-year results from the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) registry.
  • OBJECTIVES: We performed the long-term follow-up of a large cohort of patients in a multicenter study receiving left main coronary artery (LMCA) revascularization.
  • BACKGROUND: Limited information is available on long-term outcomes for patients with unprotected LMCA disease who underwent coronary stent procedure or coronary artery bypass grafting (CABG).
  • METHODS: We evaluated 2,240 patients with unprotected LMCA disease who received coronary stents (n = 1,102; 318 with bare-metal stents and 784 with drug-eluting stents) or underwent CABG (n = 1,138) between 2000 and 2006 and for whom complete follow-up data were available for at least 3 to 9 years (median 5.2 years).
  • CONCLUSIONS: During 5-year follow-up, stenting showed similar rates of mortality and of the composite of death, Q-wave MI, or stroke but higher rates of TVR as compared with CABG for patients with unprotected LMCA disease.
  • [MeSH-major] Coronary Disease / therapy. Stents
  • [MeSH-minor] Coronary Artery Bypass. Drug-Eluting Stents. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome

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  • [Copyright] Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20451344.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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75. Shimizu T, Miyakawa Y, Mitsuhashi T, Kakimoto T, Ikeda Y, Kizaki M, Hagiwara T: [Persistent neutrophilia occurring after pneumonia: a differential diagnosis of neutrophilia based on the WHO classification]. Rinsho Ketsueki; 2005 Jul;46(7):532-5
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  • [Title] [Persistent neutrophilia occurring after pneumonia: a differential diagnosis of neutrophilia based on the WHO classification].
  • Bone marrow examination revealed hypercellularity without excess of blasts and hiatus leukemia, accompanied by mild dysplasia in myeloid cells and megakaryocytes.
  • Major/minor BCR-ABL fusion genes were negative by RT-PCR.
  • As previously reported by several investigators, we often experience difficulties in distinguishing atypical CML from CNL and CMML.
  • [MeSH-major] Leukocytosis / classification. Leukocytosis / diagnosis. Neutrophils. Pneumonia, Bacterial / complications
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. World Health Organization

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  • (PMID = 16440748.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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76. Jiang Q, Chen SS, Jiang B, Jiang H, Lu Y, Qiu JY, Lu DP: [Clonal evolution of abnormal Philadelphia chromosome-negative cells after imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia]. Zhonghua Xue Ye Xue Za Zhi; 2005 Jan;26(1):23-6
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  • [Title] [Clonal evolution of abnormal Philadelphia chromosome-negative cells after imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia].
  • OBJECTIVE: To investigate clonal evolution of abnormal Philadelphia chromosome-negative cells (Ph- CE) after imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).
  • METHODS: Bone marrow cells G-banding karyotype was evaluated every 3 months in 100 patients with Ph+ CML after achieving hematologic responses on the course of imatinib therapy.
  • There were 54 patients in chronic phase (CP), 37 in accelerated phase (AP) and 9 in blast phase (BP).
  • RESULTS: After a median follow-up of 32 months (ranged 25-34 months), 11 patients, including 5 cases in CP, 5 in AP and 1 in BP, developed transient, interrupted or continuous Ph- CE after 3 - 29 months on imatinib therapy.
  • Ph- CE emerged at the beginning of Ph+ cells decreasing or after Ph+ cells disappearing.
  • The proportion of Ph- CE, was negatively correlated with the proportion of Ph+ cells (P < 0.05).
  • Ph- CE commonly included +8 (45.5%) and +Y (27.3%).
  • Five patients had additional cytogenetic abnormalities besides Ph+ in Ph- CE.
  • Seven of the patients with Ph- CE achieved a major cytogenetic response while 9 of them achieved a complete hematologic response.
  • One patient with Ph- CE in AP progressed to BP 20 months after the initiation of the therapy while the rests remained in hematologic or cytogenetic responses.
  • CONCLUSION: Ph- CE occurred in about 11% of the patients with Ph+ CML who achieved major or minor cytogenetic responses on imatinib therapy.
  • After a median follow-up of more than 2 years, most of the patients with Ph- CE were in a stable status with no disease progression.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy. Philadelphia Chromosome. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 15946504.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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77. Wang L, Zhu K, Zha X, Chen S, Yang L, Chen S, Li Y: Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia. J Hematol Oncol; 2010;3:14
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  • [Title] Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia.
  • INTRODUCTION: The development of Philadelphia chromosome (Ph) negative acute leukemia/myelodysplastic syndrome (MDS) in patients with Ph-positive chronic myeloid leukemia (CML) is very rare.
  • The features of restrictive usage and absence of partial T cell clones have been found in patients with CML.
  • However, the T-cell clonal evolution of Ph-negative malignancies during treatment for CML is still unknown.
  • OBJECTIVE: To investigate the dynamic change of clonal proliferation of T cell receptor (TCR) Valpha and Vbeta subfamilies in one CML patient who developed Ph-negative acute lymphoblastic leukemia (ALL) after interferon and imatinib therapy.
  • METHODS: The peripheral blood mononuclear cells (PBMC) samples were collected at the 3 time points (diagnosis of Ph-positive chronic phase (CP) CML, developing Ph-negative ALL and post inductive chemotherapy (CT) for Ph-negative ALL, respectively).
  • RESULTS: The CML patient who achieved complete cytogenetic remission (CCR) after 5 years of IFN-alpha therapy suddenly developed Ph-negative ALL 6 months following switch to imatinib therapy.
  • The expression pattern and clonality of TCR Valpha/Vbeta T cells changed in different disease stages.
  • Additionally, there have been obvious differences in Valpha/Vbeta subfamily of T cells between the stages of Ph-positive CML-CP and Ph-negative ALL.
  • The Valpha10 and Vbeta3 T cells evolved from oligoclonality to polyclonality, the Vbeta13 T cells changed from bioclonality to polyclonality, when Ph-negative ALL developed.
  • CONCLUSIONS: Restrictive usage and clonal proliferation of different Valpha/Vbeta subfamily T cells between the stages of Ph-positive CP and Ph-negative ALL were detected in one patient.
  • These changes may play a role in Ph- negative leukemogenesis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Philadelphia Chromosome. Receptors, Antigen, T-Cell, alpha-beta / genetics. T-Lymphocytes / immunology


78. Koşar P, Ergun E, Oztürk C, Koşar U: Anatomic variations and anomalies of the coronary arteries: 64-slice CT angiographic appearance. Diagn Interv Radiol; 2009 Dec;15(4):275-83
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  • [Title] Anatomic variations and anomalies of the coronary arteries: 64-slice CT angiographic appearance.
  • PURPOSE: To retrospectively review the 64-slice computed tomography (CT) appearance of coronary artery anatomic variants and anomalies and determine their incidence in 700 patients.
  • MATERIALS AND METHODS: CT data of 700 patients who underwent 64-slice CT angiography (CTA) because of known or suspected coronary artery disease were retrospectively reviewed by two radiologists experienced in cardiovascular radiology.
  • RESULTS: The coronary artery system was right dominant in 76%, left dominant in 9.1% and co-dominant in 14.8% of the cases.
  • Conus artery with a separate ostium in the right sinus Valsalva was observed in 22%, and in 0.2% two conus arteries originating with separate ostia were visualized.
  • The sinus node artery (SNA) originated from the right coronary artery (RCA) in 79%, from the circumflex artery (Cx) in 20%, and from the left main coronary artery (LMCA) in 0.4%.
  • LMCA was absent in 0.4%.
  • High takeoff of LMCA and RCA were observed in 0.7% and 0.1%, respectively.
  • Anomalous origin of the coronary artery from the opposite sinus was observed in 1% of the cases.
  • CONCLUSION: Complex anatomy of the coronary artery system can accurately be depicted by 64-slice CTA.
  • This modality is useful in detecting coronary artery variants and anomalies and is a valid alternative to conventional coronary angiography in their diagnosis.
  • [MeSH-major] Angiography, Digital Subtraction / methods. Coronary Angiography / methods. Coronary Disease / radiography. Coronary Vessel Anomalies / radiography. Coronary Vessels / anatomy & histology

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  • (PMID = 19957241.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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79. Vlădaia A, Ginghină C, Mereuţă A, Moldovan H: ["Needle-to-scalpel"--the benefit of urgent CABG in significant left main coronary artery stenosis]. Chirurgia (Bucur); 2008 Jul-Aug;103(4):473-7
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  • [Title] ["Needle-to-scalpel"--the benefit of urgent CABG in significant left main coronary artery stenosis].
  • [Transliterated title] "Timpul de la ac la bisturiu": beneficiul intervenţiei chirurgicale prompte in stenoza de trunchi de coronară stâng.
  • Left main coronary artery (LMCA) stenosis is a relatively infrequent but important cause of symptomatic coronary artery disease.
  • The diagnosis of left main coronary artery disease is made by coronary angiography.
  • Coronary artery bypass grafting is the first-line therapy, the standard treatment for LMCA stenosis, which improves the likelihood of survival, while percutaneous coronary intervention (PCI) is emerging as a possible alternative to surgery.
  • We present the case of a patient with history and symptoms of stable angina pectoris, especially associated with exercise, variable threshold, since four years, and who describes a worsening of symptoms in the last month; the angina had become more frequent, more prolonged and occurred at a lower threshold.
  • This investigation showed severe left main coronary artery stenosis and significant lesions in other important vessels (three-vessel disease), in a patient with normal left ventricular function.
  • The recurrence and the intensity of prolonged angina of our patient have necessitated urgent myocardial revascularization surgery with quadruple coronary-artery bypass grafting.
  • CONCLUSIONS: The advantage of coronary artery bypass grafting performed as urgent surgery for the treatment of our patient with left main coronary artery stenosis and concomitant acute coronary syndrome, shortly after coronary angiography, was obvious, significantly improved the clinical outcome, without postoperative ischemic complications.
  • [MeSH-major] Acute Coronary Syndrome / etiology. Coronary Artery Bypass. Coronary Stenosis / diagnosis. Coronary Stenosis / surgery

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  • (PMID = 18780623.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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80. Courtis J, Rodés-Cabau J, Larose E, Potvin JM, Déry JP, Larochellière RD, Côté M, Cousterousse O, Nguyen CM, Proulx G, Rinfret S, Bertrand OF: Usefulness of coronary fractional flow reserve measurements in guiding clinical decisions in intermediate or equivocal left main coronary stenoses. Am J Cardiol; 2009 Apr 1;103(7):943-9
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  • [Title] Usefulness of coronary fractional flow reserve measurements in guiding clinical decisions in intermediate or equivocal left main coronary stenoses.
  • The objectives of this study were to evaluate the usefulness of fractional flow reserve (FFR) measurements to guide the clinical decision in patients with intermediate left main coronary artery (LMCA) stenosis and to determine the predictors of major adverse cardiac events (MACE) -- cardiac death, myocardial infarction, coronary revascularization -- in such cases; 142 consecutive patients with intermediate LMCA stenosis (mean percent diameter stenosis 42 +/- 13%) were included.
  • All patients underwent FFR measurement after intracoronary administration of adenosine at a dose > or =30 microg.
  • At 14 +/- 11 months follow-up, the incidence of MACE related to the LMCA stenosis was 13% in the medical treatment group and 7% in the revascularization group (p = 0.27).
  • In conclusion, FFR measurement is helpful in guiding the decision whether to revascularize patients with intermediate LMCA stenosis.
  • However, patients with diabetes remain at higher risk, and higher doses than previously recommended of intracoronary adenosine might have to be used in the evaluation of LMCA stenosis.
  • [MeSH-minor] Adenosine / administration & dosage. Blood Pressure / physiology. Diagnosis, Differential. Electrocardiography. Female. Humans. Injections, Intra-Arterial. Male. Middle Aged. Myocardial Revascularization / methods. Vasodilator Agents / administration & dosage

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  • (PMID = 19327420.001).
  • [ISSN] 1879-1913
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; K72T3FS567 / Adenosine
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81. Larsson N, Billström R, Lilljebjörn H, Lassen C, Richter J, Ekblom M, Fioretos T: Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells. Cancer Genet Cytogenet; 2010 Jun;199(2):89-95
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  • [Title] Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.
  • Despite the recent success of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML), approximately 2-17% of patients develop clonal cytogenetic changes in the Philadelphia-negative (Ph(-)) cell population.
  • A fraction of these patients, in particular those displaying trisomy 8 or monosomy 7, are at risk of developing a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
  • Consequently, there is a need to characterize the clinical features of such cases and to increase our understanding of the pathogenetic mechanisms underlying the emergence of clonal cytogenetic changes in Ph(-) cells.
  • Here we describe the case of a patient with CML who developed monosomy 7 in Ph(-) cells during dasatinib therapy.
  • Given the strong association between monosomy 7 and mutation of genes involved in the RAS pathway in juvenile myelomonocytic leukemia, we also screened for pathogenetic variants in KRAS, NRAS, and PTPN11, but did not detect any changes.
  • [MeSH-major] Chromosomes, Human, Pair 7 / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Acute / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Monosomy. Pyrimidines / therapeutic use. Thiazoles / therapeutic use


82. Breccia M, Russo E, De Propris MS, Frustaci A, Alimena G: Atypical chronic myeloid leukaemia with CD117-positive blast cells treated with imatinib: A report of two cases. Acta Haematol; 2006;116(3):211-2
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  • [Title] Atypical chronic myeloid leukaemia with CD117-positive blast cells treated with imatinib: A report of two cases.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Piperazines / therapeutic use. Proto-Oncogene Proteins c-kit / analysis. Pyrimidines / therapeutic use

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  • (PMID = 17016042.001).
  • [ISSN] 0001-5792
  • [Journal-full-title] Acta haematologica
  • [ISO-abbreviation] Acta Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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83. Latsios G, Tsioufis K, Tousoulis D, Kallikazaros I, Stefanadis C: Common origin of both right and left coronary arteries from the right sinus of Valsalva. Int J Cardiol; 2008 Aug 18;128(2):e60-1
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  • [Title] Common origin of both right and left coronary arteries from the right sinus of Valsalva.
  • Anomalous origin of the left main coronary artery (LMCA) from the right sinus of Valsalva (RSOV) represents in about 2 per 10,000 patients undergoing diagnostic cardiac catheterization.
  • We describe the case of a middle-aged woman, suffering from typical angina pectoris, with an anomalous common origin of all coronary arteries from the RSOV.

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  • (PMID = 17692404.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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84. Park SJ, Kim YH: Percutaneous coronary intervention for unprotected left main coronary artery stenosis. World J Cardiol; 2010 Apr 26;2(4):78-88
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  • [Title] Percutaneous coronary intervention for unprotected left main coronary artery stenosis.
  • Hemodynamically significant left main coronary artery stenosis (LMCA) is found in around 4% of diagnostic coronary angiograms and is known as unprotected LMCA stenosis if the left coronary artery and left circumflex artery has no previous patent grafts.
  • Previous randomized studies have demonstrated a significant reduction in mortality when revascularization by coronary artery bypass graft (CABG) surgery was undertaken compared with medical treatment.
  • However, with the advent of drug-eluting stents (DES), the long term outcomes of PCI with DES to treat unprotected LMCA stenoses have been acceptable.
  • Therefore, apart from the current guidelines, PCI for treatment of unprotected LMCA stenosis is often undertaken in individuals who are at a very high risk of CABG or refuse to undergo a sternotomy.
  • Future randomized studies comparing CABG vs PCI using DES for treatment of unprotected LMCA stenosis would be a great advance in clinical knowledge for the adoption of appropriate treatment.

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  • (PMID = 21160702.001).
  • [ISSN] 1949-8462
  • [Journal-full-title] World journal of cardiology
  • [ISO-abbreviation] World J Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998877
  • [Keywords] NOTNLM ; Bypass surgery / Left main / Prognosis / Restenosis / Stent
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85. Chieffo A, Park SJ, Meliga E, Sheiban I, Lee MS, Latib A, Kim YH, Valgimigli M, Sillano D, Magni V, Biondi-Zoccai G, Montorfano M, Airoldi F, Rogacka R, Carlino M, Michev I, Lee CW, Hong MK, Park SW, Moretti C, Bonizzoni E, Sangiorgi GM, Tobis J, Serruys PW, Colombo A: Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry. Eur Heart J; 2008 Sep;29(17):2108-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry.
  • AIMS: To evaluate the occurrence of late and very late stent thrombosis (ST) following elective drug-eluting stent (DES) implantation in unprotected left main coronary artery (LMCA) stenosis in a large multicentre registry.
  • METHODS AND RESULTS: All 731 consecutive patients who had sirolimus- or paclitaxel-eluting stent electively implanted in de novo lesions on unprotected LMCA in five centres were included.
  • Four (0.5%) patients had a definite ST: three early (two acute and one subacute) and one late ST, no cases of very late definite ST were recorded.
  • CONCLUSION: Elective treatment of LMCA stenosis with DES appears safe with a 0.9% incidence of definite and probable ST at 29.5 ± 13.7 months.

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  • [CommentIn] Eur Heart J. 2008 Sep;29(17):2064-6 [18664463.001]
  • (PMID = 18565967.001).
  • [ISSN] 1522-9645
  • [Journal-full-title] European heart journal
  • [ISO-abbreviation] Eur. Heart J.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tubulin Modulators; P88XT4IS4D / Paclitaxel; W36ZG6FT64 / Sirolimus
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86. Hackanson B, Rückert A, Lübbert M: Hyperleukocytotic secondary acute myeloid leukemia (AML) with sole monosomy 7 as sequela of Philadelphia-chromosome positive chronic myeloid leukemia (CML). Eur J Haematol; 2009 Dec 1;83(6):611-2
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  • [Title] Hyperleukocytotic secondary acute myeloid leukemia (AML) with sole monosomy 7 as sequela of Philadelphia-chromosome positive chronic myeloid leukemia (CML).
  • [MeSH-major] Chromosomes, Human, Pair 7. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Acute / genetics. Leukocytosis / etiology. Monosomy
  • [MeSH-minor] Aged. Anemia, Refractory, with Excess of Blasts / etiology. Anemia, Refractory, with Excess of Blasts / genetics. Anemia, Refractory, with Excess of Blasts / pathology. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Benzamides. Chromosome Deletion. Cytarabine / administration & dosage. Disease Progression. Fatal Outcome. Humans. Imatinib Mesylate. Interferon-alpha / administration & dosage. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / pathology. Male. Philadelphia Chromosome. Piperazines / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Pyrimidines / therapeutic use. Selection, Genetic


87. Todorić-Zivanović B, Marisavljević D, Surace C, Cemerikić V, Marković O, Krtolica K, Tatomirović Z, Cikota B, Magić Z, Rocchi M: A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1). Cancer Genet Cytogenet; 2006 Apr 15;166(2):180-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1).
  • Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients.
  • Cryptic or "masked" BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level.
  • Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9)(p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21.
  • [MeSH-major] Chromosomes, Human, Pair 6 / genetics. Chromosomes, Human, Pair 9 / genetics. Fusion Proteins, bcr-abl / genetics. Gene Rearrangement / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Translocation, Genetic / genetics


88. Jing Y, Jiang F, Lin S, Wang FT, Fang MY: [Application of fluorescence in situ hybridization technique in diagnosis of variant Ph chromosome translocation and Ph-negative chronic myelocytic leukemia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2010 Oct;27(5):563-6
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  • [Title] [Application of fluorescence in situ hybridization technique in diagnosis of variant Ph chromosome translocation and Ph-negative chronic myelocytic leukemia].
  • OBJECTIVE: To explore the value of fluorescence in situ hybridization (FISH) technique in diagnosis of variant Ph chromosome translocation (VT) and Ph chromosome-negative chronic myelocytic leukemia (CML).
  • METHODS: Nine CML patients with VT and 2 Ph chromosome-negative CML patients confirmed by R banding were assayed with dual color-dual fusion BCR/ABL probe by FISH.
  • The 2 Ph-negative CML patients had normal karyotypes; FISH was positive and the signal feature was 1R1G2Y and 1R1G1Y respectively.
  • CONCLUSION: FISH can provide better diagnosis for CML with VT and Ph-negative CML.
  • So FISH is a complementary method to banding technique in diagnosis of CML.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics. Translocation, Genetic
  • [MeSH-minor] Adult. Aged. Chromosomes / genetics. Female. Fusion Proteins, bcr-abl / genetics. Humans. Male. Middle Aged. Philadelphia Chromosome. Young Adult

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  • (PMID = 20931538.001).
  • [ISSN] 1003-9406
  • [Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
  • [ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.10.2 / Fusion Proteins, bcr-abl
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89. Caramazza D, Caracciolo C, Barone R, Malato A, Saccullo G, Cigna V, Berretta S, Schinocca L, Quintini G, Abbadessa V, Di Raimondo F, Siragusa S: Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms. Ann Hematol; 2009 Oct;88(10):967-71
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  • [Title] Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms.
  • The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive.
  • The association was measured at diagnosis or before thrombotic events: a multivariable analysis was carried out using data at baseline and time-dependent covariates.
  • We found that white blood cells (WBC) count above 9.5 x 10(9)/L at diagnosis (baseline analysis) was associated with thrombosis during the follow-up (Hazard Ratio [HR] of 1.8, p 0.03).
  • [MeSH-minor] Aged. Female. Humans. Hydroxyurea / pharmacology. Hydroxyurea / therapeutic use. Janus Kinase 2 / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / complications. Leukocyte Count. Male. Middle Aged. Multivariate Analysis

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  • (PMID = 19214510.001).
  • [ISSN] 1432-0584
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2; X6Q56QN5QC / Hydroxyurea
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90. Seung KB, Kim YH, Park DW, Lee BK, Lee CW, Hong MK, Kim PJ, Chung WS, Tahk SJ, Park SW, Park SJ: Effectiveness of sirolimus-eluting stent implantation for the treatment of ostial left anterior descending artery stenosis with intravascular ultrasound guidance. J Am Coll Cardiol; 2005 Sep 6;46(5):787-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of sirolimus-eluting stent implantation for the treatment of ostial left anterior descending artery stenosis with intravascular ultrasound guidance.
  • OBJECTIVES: This study was designed to evaluate the clinical and angiographic outcomes of sirolimus-eluting stent (SES) implantation for ostial left anterior descending (LAD) lesions compared with bare-metal stent (BMS) implantation.
  • In the SES group, for complete lesion coverage, stent positioning was intentionally extended into the distal left main coronary artery (LMCA) in 23 patients (34%) with intermediate LMCA narrowing.
  • In the SES group, there were no restenoses in cases with LMCA coverage, compared with three restenoses (7.9%) in cases with precise stent positioning (p = NS).
  • This finding may be associated with reduced neointimal hyperplasia and complete lesion coverage.

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  • (PMID = 16139126.001).
  • [ISSN] 0735-1097
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Delayed-Action Preparations; 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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91. Hussein K, Dralle W, Theophile K, Kreipe H, Bock O: Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm. Ann Hematol; 2009 Apr;88(4):325-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm.
  • A characteristic of Philadelphia chromosome-negative myeloproliferative neoplasm (Ph(-) MPN) is the abundance of morphologically aberrant megakaryocytes.
  • Based on previously published in vitro megakaryocytic differentiation assay data, we selected miRNA 10a, 17-5p, 20a and 126 and potential target proteins (HOXA1, RUNX1) for analysis of laser-microdissected bone marrow megakaryocytes from Ph(-) MPN and controls (n=66).
  • Furthermore, we tested a potential influence of cytoreductive treatment on miRNA expression in bone marrow cells during the course of Ph(-) MPN (n=18).
  • In summary, miRNA 17-5p, 20a and 126 are constitutively expressed in Ph(-) MPN megakaryopoiesis while low or absent miRNA 10a appeared to correlate with strong megakaryocytic HOXA1 protein expression.
  • [MeSH-minor] Bone Marrow Cells. Core Binding Factor Alpha 2 Subunit. Gene Expression. Homeodomain Proteins. Humans. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative. Transcription Factors

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  • (PMID = 18773208.001).
  • [ISSN] 1432-0584
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / Homeodomain Proteins; 0 / MicroRNAs; 0 / RUNX1 protein, human; 0 / Transcription Factors; 0 / homeobox A1 protein
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92. Jong GP, Ma T, Chou P, Shyu MY, Tseng WK, Chang TC: Reciprocal changes in 12-lead electrocardiography can predict left main coronary artery lesion in patients with acute myocardial infarction. Int Heart J; 2006 Jan;47(1):13-20
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  • [Title] Reciprocal changes in 12-lead electrocardiography can predict left main coronary artery lesion in patients with acute myocardial infarction.
  • Acute left main coronary artery (LMCA) occlusion may result in acute myocardial infarction (AMI) or sudden death.
  • ST elevation in the aVR and V1 leads is reported to be valuable in recognizing LMCA occlusion.
  • This study aimed to determine the reciprocal ST segment depression of 12-lead ECGs associated with acute LMCA occlusion.
  • From January 2000 to December 2004, 61 patients who underwent emergency percutaneous coronary intervention in 3 hospitals due to AMI associated with LMCA (n = 18) and a left anterior descending coronary artery (LADCA) (n = 43) proximal lesion were selected.
  • Reciprocal ST segment depression occurred in leads aVF, V(2), V(3), V(4), V(5), and V(6) with significantly higher incidence in the LMCA group than in the LADCA group.
  • Stepwise linear multivariate discriminant analysis indicated that ST segment depression in leads aVF, V(2), and V(4) could distinguish the LMCA group from the LADCA group.
  • We concluded that reciprocal ST segment depression in leads V(2), V(4), and aVF of a 12-lead ECG is an important predictor of acute LMCA occlusion.
  • [MeSH-major] Coronary Occlusion / diagnosis. Electrocardiography. Myocardial Infarction / diagnosis

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  • (PMID = 16479036.001).
  • [ISSN] 1349-2365
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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93. Park SJ: Is stenting a preferred option for unprotected left main coronary artery disease in the drug-eluting stent era? Indian Heart J; 2007 Mar-Apr;59(2 Suppl B):B105-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is stenting a preferred option for unprotected left main coronary artery disease in the drug-eluting stent era?
  • Coronary artery bypass graft (CABG) has been the established treatment for left main coronary artery (LMCA) disease.
  • LMCA disease has been considered to be a challenge for interventional cardiologist for more than 25 years.
  • The early experience with drug-eluting stent (DES) in unprotected LMCA reveals reduced rates of restenosis and associated clinical outcomes when compared with patients who were treated with BMS.
  • However, up to now, effectiveness of DES is not enough to replace CABG in LMCA revascularization.
  • Based on these trials, it is likely that, for selected patients, DES may be regarded as a preferred revascularization strategy for LMCA disease.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Disease / therapy. Coronary Restenosis / prevention & control. Drug-Eluting Stents
  • [MeSH-minor] Coronary Artery Bypass. Hospital Mortality. Humans. Randomized Controlled Trials as Topic

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  • (PMID = 19153426.001).
  • [ISSN] 0019-4832
  • [Journal-full-title] Indian heart journal
  • [ISO-abbreviation] Indian Heart J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 39
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94. Hall J, Foucar K: Diagnosing myelodysplastic/myeloproliferative neoplasms: laboratory testing strategies to exclude other disorders. Int J Lab Hematol; 2010 Dec;32(6 Pt 2):559-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The 2008 World Health Organization classification of myeloid neoplasms includes the diagnostic category, myelodysplastic/myeloproliferative neoplasms (MDS/MPN), which encompasses those rare clonal myeloid proliferations that at initial presentation, show overlapping myeloproliferative and myelodysplastic features, making classification as either a myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) problematic.
  • There are four main subcategories, chronic myelomonocytic leukemia (CMML), atypical chronic myeloid leukemia, BCR-ABL1-negative (aCML), juvenile myelomonocytic leukemia (JMML), and myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U), which also includes the provisional entity, refractory anemia with ring sideroblasts associated with marked thrombocytosis (RARS-T).
  • Notably, the morphological features typical of MDS/MPNs are not specific and can be seen in other myeloid neoplasms at presentation or as part of disease progression or transformation.
  • CONCLUSION: The most appropriate classification of myeloid neoplasms presenting with hybrid myelodysplastic/myeloproliferative features requires a comprehensive clinical and laboratory assessment with careful integration of the morphological, immunophenotypic, genetic, and clinical characteristics.
  • [MeSH-major] Myelodysplastic Syndromes / diagnosis. Myeloproliferative Disorders / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anemia, Refractory, with Excess of Blasts / diagnosis. Bone Marrow / pathology. Diagnosis, Differential. Erythrocytes / pathology. Female. Flow Cytometry. Granulocytes / pathology. Humans. Immunohistochemistry. Leukemia, Myeloid / diagnosis. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis. Leukemia, Myelomonocytic, Chronic / diagnosis. Leukemia, Myelomonocytic, Juvenile / diagnosis. Male. Megakaryocytes / pathology. Neutrophils / pathology. Proto-Oncogene Proteins c-abl / analysis. Proto-Oncogene Proteins c-bcr / analysis. Thrombocytosis / diagnosis

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  • [Copyright] © 2010 Blackwell Publishing Ltd.
  • (PMID = 20670271.001).
  • [ISSN] 1751-553X
  • [Journal-full-title] International journal of laboratory hematology
  • [ISO-abbreviation] Int J Lab Hematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.2 / Proto-Oncogene Proteins c-abl; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr
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95. Yorgun H, Hazırolan T, Kaya EB, Gürses KM, Evranos B, Canpolat U, Karçaaltıncaba M, Ateş AH, Aytemir K, Tokgözoğlu L, Kabakcı G, Oto A: [The prevalence of coronary artery anomalies in patients undergoing multidetector computed tomography for the evaluation of coronary artery disease]. Turk Kardiyol Dern Ars; 2010 Jul;38(5):341-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The prevalence of coronary artery anomalies in patients undergoing multidetector computed tomography for the evaluation of coronary artery disease].
  • OBJECTIVES: Coronary artery anomalies (CAA) can be detected by multidetector computed tomography (MDCT) with a high accuracy.
  • The purpose of this study was to evaluate the prevalence of CAA in subjects undergoing MSCT coronary angiography for the assessment of coronary artery disease.
  • STUDY DESIGN: This retrospective study included 1,056 patients (534 males, 522 females; mean age 58.8±11.5 years) who underwent coronary dual-source 64-slice MDCT for the assessment of coronary artery disease.
  • The reconstructions were obtained in all cardiac phases at 50-millisecond intervals at a slice thickness of 0.75 mm and a reconstruction increment of 0.5 mm.
  • These included high take-off of the left main coronary artery (LMCA) (n=3, 0.3%), absence of the LMCA (n=3, 0.3%), coronary fistula (n=2, 0.2%), right-sided origin of the circumflex artery (n=2, 0.2%), and left anterior descending artery originating from the right coronary artery (n=1, 0.1%).
  • CONCLUSION: Multidetector computed tomography is a reliable and useful noninvasive method to identify and define anomalous coronary arteries and their course and can be used as the first-line diagnostic tool in the evaluation of CAAs.
  • [MeSH-major] Coronary Artery Disease / radiography. Coronary Vessel Anomalies / epidemiology

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  • (PMID = 21200104.001).
  • [ISSN] 1016-5169
  • [Journal-full-title] Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
  • [ISO-abbreviation] Turk Kardiyol Dern Ars
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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96. Toms DR, Cannick L, Stuart RK, Jenrette JM, Terwiliger L: Helical tomotherapy for extramedullary hematopoiesis involving the pericardium in a patient with chronic myeloid leukemia. Jpn J Radiol; 2010 Jul;28(6):476-8
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  • [Title] Helical tomotherapy for extramedullary hematopoiesis involving the pericardium in a patient with chronic myeloid leukemia.
  • The phenomenon occurs in a number of disease states, notably in myelofibrosis, thalassemia, immune thrombocytopenic purpura, sickle cell anemia, polycythemia vera, and myelodysplastic syndrome.
  • The present case report describes a patient with the diagnosis of atypical chronic myeloid leukemia and myelofibrosis who subsequently developed EMH of the pericardium with effusion and tamponade.
  • [MeSH-major] Heart Diseases / radiotherapy. Hematopoiesis, Extramedullary / radiation effects. Leukemia, Myeloid / complications. Pericardium / radiation effects. Tomography, Spiral Computed / methods


97. Wiśniewska-Szmyt J, Kubica J, Sukiennik A, Radomski M, Rychter M, Jabłoński M, Białoszyński T, Koziński M, Grabczewska Z, Grześk G: One-year outcomes of left main coronary artery stenting in patients with cardiogenic shock. Cardiol J; 2007;14(1):67-75
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  • [Title] One-year outcomes of left main coronary artery stenting in patients with cardiogenic shock.
  • The aim of the study was to evaluate the outcomes of angioplasty and stenting in patients with cardiogenic shock caused by left main coronary artery (LMCA) disease.
  • METHODS: A group of 71 consecutive patients managed for LMCA disease in an emergency setting (38 patients in cardiogenic shock and 33 without shock symptoms) were followed up clinically and angiographically for one year.
  • Multivariate analysis revealed the following independent predictors of cardiogenic shock in patients undergoing emergency LMCA angioplasty: STEMI as the reason for intervention (OR 14.1; 95% CI 3.71-53.7; p < 0.0002) and a small minimal lumen diameter before the procedure (OR 0.43; 95% CI 0.2-0.93; p < 0.04).

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  • (PMID = 18651437.001).
  • [ISSN] 1897-5593
  • [Journal-full-title] Cardiology journal
  • [ISO-abbreviation] Cardiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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98. Chieffo A, Morici N, Maisano F, Bonizzoni E, Cosgrave J, Montorfano M, Airoldi F, Carlino M, Michev I, Melzi G, Sangiorgi G, Alfieri O, Colombo A: Percutaneous treatment with drug-eluting stent implantation versus bypass surgery for unprotected left main stenosis: a single-center experience. Circulation; 2006 May 30;113(21):2542-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Percutaneous treatment with drug-eluting stent implantation versus bypass surgery for unprotected left main stenosis: a single-center experience.
  • BACKGROUND: Improvements in results with percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may extend their use in patients with left main coronary artery (LMCA) stenosis.
  • METHODS AND RESULTS: Two hundred forty-nine patients with LMCA stenosis were treated with PCI and DES implantation (n=107) or coronary artery bypass grafting (CABG) (n=142), in a single center, between March 2002 and July 2004.
  • At 1 year, there was no statistical difference in the occurrence of death in PCI versus CABG both for the unadjusted (OR=0.291; 95% CI=0.054 to 1.085; P=0.0710) and adjusted analyses (OR=0.331; 95% CI=0.055 to 1.404; P=0.1673).
  • CONCLUSIONS: At 1 year, in this single-center, retrospective experience, there was no difference in the degree of protection against death, stroke, myocardial infarction, and revascularization between PCI with DES and CABG for LMCA disease.
  • [MeSH-major] Angioplasty, Balloon, Coronary. Coronary Artery Bypass. Coronary Stenosis / therapy. Stents

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  • [CommentIn] Circulation. 2006 Nov 7;114(19):e573; author reply e575 [17088469.001]
  • [CommentIn] Circulation. 2006 Nov 7;114(19):e574; author reply e575 [17088470.001]
  • [CommentIn] Circulation. 2006 May 30;113(21):2480-4 [16735688.001]
  • (PMID = 16717151.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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99. Tommaso CL: PCI for LMCA stenosis--is it time to ride the rank bull? Catheter Cardiovasc Interv; 2006 Sep;68(3):363-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PCI for LMCA stenosis--is it time to ride the rank bull?

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  • (PMID = 16894577.001).
  • [ISSN] 1522-1946
  • [Journal-full-title] Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • [ISO-abbreviation] Catheter Cardiovasc Interv
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible
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100. Breccia M, Biondo F, Latagliata R, Carmosino I, Mandelli F, Alimena G: Identification of risk factors in atypical chronic myeloid leukemia. Haematologica; 2006 Nov;91(11):1566-8
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  • [Title] Identification of risk factors in atypical chronic myeloid leukemia.
  • In the WHO classification atypical chronic myeloid leukemia (CML) has been considered as a new distinct clinical entity included in the category of mixed myeloproliferative/myelodysplastic disorders.
  • Little is known about this uncommon disease, whose incidence is about of one-two cases every 100 cases of Ph-positive CML.
  • We analyzed our series of 55 patients diagnosed as having aCML, with the aim of identifying clinical factors of possible prognostic value on survival and acute transformation.
  • [MeSH-major] Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis






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