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Items 1 to 62 of about 62
1. Tzimas GN, Vali K, Deschênes M, Marcus VA, Barkun JS, Tchervenkov JI, Metrakos PP: Liver transplantation for metastases from a bile duct carcinoid. HPB (Oxford); 2006;8(1):67-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver transplantation for metastases from a bile duct carcinoid.
  • Pathology revealed an atypical carcinoid tumour of the left extrahepatic bile duct, with perineural and lymphatic invasion.
  • DISCUSSION: To our knowledge this is the first report of a biliary carcinoid treated with hepatectomy and finally with liver transplantation, with excellent results.

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  • [Cites] Transplant Proc. 2002 Feb;34(1):264-5 [11959276.001]
  • [Cites] J Clin Gastroenterol. 1996 Jul;23(1):63-5 [8835905.001]
  • [Cites] Can J Surg. 1999 Feb;42(1):59-63 [10071590.001]
  • (PMID = 18333243.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2131368
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2. John BM, Song MH, Park YS, Jo YJ, Kim SH, Lee HH, Kim SK, Jung SH, Kim DH, Kim DH: [A case of carcinoid tumor of the common bile duct]. Korean J Gastroenterol; 2006 Apr;47(4):320-3
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of carcinoid tumor of the common bile duct].
  • Majority of malignant neoplasms arising from the extrahepatic bile duct are adenocarcinomas.
  • Carcinoid tumors at this site are extremely rare.
  • We report a 67-year-old woman with malignant carcinoid tumor of the common bile duct.
  • She underwent Whipple's operation and was diagnosed as malignant carcinoid tumor histologically and immunohistochemically.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 16632986.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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3. Meinardi JR, van den Berg G, Wolffenbuttel BH, Kema IP, Dullaart RP: Cyclical Cushing's syndrome due to an atypical thymic carcinoid. Neth J Med; 2006 Jan;64(1):23-7
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclical Cushing's syndrome due to an atypical thymic carcinoid.
  • A tumour in the right anterior mediastinum was revealed on octreotide receptor scintigraphy, which had initially been overlooked on computed tomography (CT) scanning.
  • A thymic carcinoid tumour was suspected, which was supported by increased levels of urinary serotonin, while platelet serotonin and urinary 5-hydroxyindoleacetic acid levels were normal.
  • The tumour was removed surgically and histological examination revealed an atypical thymic carcinoid tumour.
  • Repeated measurement of urinary cortisol excretion is then required to establish or rule out the diagnosis.
  • [MeSH-major] ACTH Syndrome, Ectopic / complications. Carcinoid Tumor / complications. Cushing Syndrome / etiology. Thymus Neoplasms / complications


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4. Thomas R, Christopher DJ, Balamugesh T, Shah A: Clinico-pathologic study of pulmonary carcinoid tumours--a retrospective analysis and review of literature. Respir Med; 2008 Nov;102(11):1611-4
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinico-pathologic study of pulmonary carcinoid tumours--a retrospective analysis and review of literature.
  • OBJECTIVE: To determine the characteristic clinico-pathologic features of pulmonary carcinoid tumours in India.
  • METHODS: Retrospective analysis of the clinico-pathologic and radiologic data of patients with pulmonary carcinoid tumours from the department of Pulmonary Medicine of the Christian Medical College, a tertiary care teaching hospital in Southern India, over a study period of 3 years (2001-2004).
  • RESULTS: There were 25 cases of pulmonary carcinoid tumours: typical 22 (88%) and atypical 3 (12%).
  • There were 3 smokers (all of whom were males) in the typical carcinoid group and none in the atypical carcinoid group.
  • Carcinoid syndrome was not present in any patient.
  • Diagnosis was made by flexible bronchoscopy and bronchial biopsy in 23 patients (92%).
  • The tumour bled significantly following biopsy in most patients; however, there was no mortality, and only 1 patient required blood transfusion.
  • CONCLUSION: The clinico-pathologic and radiologic features of pulmonary carcinoid tumours are presented.
  • We report the first series of pulmonary carcinoid tumours from India.
  • [MeSH-major] Carcinoid Tumor / pathology. Lung Neoplasms / pathology

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  • (PMID = 18614346.001).
  • [ISSN] 1532-3064
  • [Journal-full-title] Respiratory medicine
  • [ISO-abbreviation] Respir Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 19
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5. Erdem R, Slabbynck H, Van den Branden F: Carcinoid crisis with fatal coronary spasm in a small localized peripheral bronchial carcinoid. Acta Cardiol; 2010 Aug;65(4):471-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid crisis with fatal coronary spasm in a small localized peripheral bronchial carcinoid.
  • Presumptive coronary artery spasm, with characteristic ST-segment elevation followed by ventricular arrhythmia and cardiac arrest, is a very uncommon manifestation of the carcinoid crisis and has been shown on angiography only once in a patient with co-existing extensive atheromatous disease.
  • We present the history of a 70-year-old man with angiographically documented fatal diffuse coronary spasm in the absence of significant atheromatosis, related to an unprovoked carcinoid crisis caused by a small peripheral atypical carcinoid tumour in the absence of metastasis.
  • [MeSH-major] Bronchial Neoplasms / complications. Coronary Vasospasm / etiology. Malignant Carcinoid Syndrome / complications

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  • (PMID = 20821943.001).
  • [ISSN] 0001-5385
  • [Journal-full-title] Acta cardiologica
  • [ISO-abbreviation] Acta Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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6. Vigg A, Mantri S, Swarnalata G, Mulay K: Atypical carcinoid tumour. Indian J Chest Dis Allied Sci; 2005 Jul-Sep;47(3):213-5
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  • [Title] Atypical carcinoid tumour.
  • Carcinoid tumour is a rare entity accounting for less than two percent of bronchial neoplasms.
  • More offten, it presents as a central endobronchial tumour.
  • The peripheral type of carcinoid tumour is relatively rare.
  • [MeSH-major] Carcinoid Tumor / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans

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  • (PMID = 16022152.001).
  • [ISSN] 0377-9343
  • [Journal-full-title] The Indian journal of chest diseases & allied sciences
  • [ISO-abbreviation] Indian J Chest Dis Allied Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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7. Simpson LK, Ostlere LS, Harland C, Gharaie S: Treatment with carbon dioxide laser of painful skin metastases from a laryngeal neuroendocrine carcinoma. Clin Exp Dermatol; 2009 Dec;34(8):e873-5
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  • An 82-year-old man presented with multiple, exquisitely painful skin metastases from an atypical carcinoid tumour of the larynx.

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  • (PMID = 20055852.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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8. Arora R, Gupta R, Sharma A, Dinda AK: Primary neuroendocrine carcinoma of thymus: a rare cause of Cushing's syndrome. Indian J Pathol Microbiol; 2010 Jan-Mar;53(1):148-51
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In contrast, neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) of thymus are extremely rare.
  • We describe three cases of rare atypical carcinoid tumor (neuroendocrine carcinoma) of the thymus.
  • Excision of tumors and histological examination of the three tumors showed a carcinoid tumor with nuclear pleomorphism, increased mitotic activity and focal necrosis.
  • The features suggested a diagnosis of atypical carcinoid tumor in all the three cases.
  • The tumor cells in Cases 1 and 2 showed focal immunohistochemical staining for ACTH.
  • Atypical carcinoid (neuroendocrine carcinoma, well-differentiated and moderately-differentiated) of the thymus is a rare thymic tumor which carries a worse prognosis compared to thymoma and requires aggressive therapy.
  • Hence, an accurate diagnosis is essential.
  • [MeSH-major] Carcinoma, Neuroendocrine / complications. Carcinoma, Neuroendocrine / diagnosis. Cushing Syndrome / etiology. Thymus Gland / pathology. Thymus Neoplasms / complications. Thymus Neoplasms / diagnosis

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  • (PMID = 20090249.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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9. Pein MK, Holzhausen H, Kösling S, Bartel-Friedrich S, Knipping S: [Atypical carcinoid of the larynx. Case report and review of literature]. HNO; 2010 Aug;58(8):812-7
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Atypical carcinoid of the larynx. Case report and review of literature].
  • To date, no diagnosis or treatment guidelines have been established for this entity.
  • Initial laryngoscopy showed a tumour at the laryngeal epiglottic surface.
  • Staging demonstrated an atypical carcinoid tumour with local lymph-node metastasis.
  • CONCLUSION: In atypical carcinoid tumours total resection as well as bilateral neck dissection should be performed, even in cN0 cases.
  • [MeSH-major] Carcinoid Tumor / surgery. Laryngeal Neoplasms / surgery

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  • (PMID = 20480128.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
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10. Kim DH, Song MH, Kim DH: Malignant carcinoid tumor of the common bile duct: report of a case. Surg Today; 2006;36(5):485-9
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant carcinoid tumor of the common bile duct: report of a case.
  • Carcinoid tumors of the extrahepatic bile duct are exceedingly rare and account for between 0.1% and 2% of all gastrointestinal carcinoid tumors, with most reported cases arising from the gallbladder.
  • We herein present what we believe is only the 47th reported case of a primary carcinoid tumor occurring in the extrahepatic bile ducts.
  • Laboratory and imaging studies gave results that were consistent with a malignant obstruction in the common bile duct.
  • The tumor had invaded the adjacent pancreatic tissues.
  • The final pathologic diagnosis was well-differentiated carcinoid tumor of a malignant nature.
  • [MeSH-major] Carcinoid Tumor / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 16633759.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 21
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11. Felekouras E, Petrou A, Bramis K, Prassas E, Papaconstantinou I, Dimitriou N, Pazaiti A, Tsigris C, Giannopoulos A: Malignant carcinoid tumor of the cystic duct: a rare cause of bile duct obstruction. Hepatobiliary Pancreat Dis Int; 2009 Dec;8(6):640-6
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant carcinoid tumor of the cystic duct: a rare cause of bile duct obstruction.
  • BACKGROUND: Carcinoid tumors of the extrahepatic biliary tree are extremely rare malignancies, accounting for 0.2%-2% of all gastrointestinal carcinoid tumors, while carcinoids of the cystic duct are an uncommon entity and an extremely unusual cause of bile duct obstruction.
  • METHODS: After an extensive literature review, we retrospectively analysed 61 cases of carcinoid tumor of the biliary tree as well as one additional case of a 60-year-old female with symptoms and laboratory/imaging examination findings compatible with those of a malignant biliary tract obstruction.
  • Compared to cholangiocarcinoma, analysis of the reviewed group indicates an increased incidence of extrahepatic carcinoid tumors in younger persons along with a slight female predominance.
  • CONCLUSIONS: Carcinoid tumors obstructing the biliary tree are extremely difficult to diagnose preoperatively, and nearly impossible to differentiate from non-neuroendocrine tumors.
  • As surgery offers the only potential cure for both biliary carcinoids and cholangiocarcinoma, we recommend aggressive surgical therapy as the treatment of choice in every case of potentially resectable biliary tumor.
  • [MeSH-major] Bile Duct Neoplasms / complications. Carcinoid Tumor / complications. Cholestasis / etiology. Cystic Duct / pathology

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  • (PMID = 20007084.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 69
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12. Ulusan S, Kizilkilic O, Yildirim T, Tercan F, Bolat F, Yildirim S: Primary hepatic carcinoid tumor: dynamic CT findings. Abdom Imaging; 2005 May-Jun;30(3):281-5
MedlinePlus Health Information. consumer health - Liver Cancer.

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  • [Title] Primary hepatic carcinoid tumor: dynamic CT findings.
  • Most carcinoid tumors involve the gastrointestinal tract or respiratory system.
  • Primary hepatic carcinoid tumor is a rare entity.
  • She was diagnosed with primary hepatic carcinoid tumor based on radiologic and laboratory findings, namely a mass in the fifth segment of the liver and markedly elevated levels of 5-hydroxyindole acetic acid in the urine.
  • Histologic and immunohistochemical findings of the resected liver segment showed a malignant carcinoid tumor of the liver.
  • [MeSH-major] Carcinoid Tumor / radiography. Liver Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 15785908.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Zinnamosca L, Petramala L, Cotesta D, Marinelli C, Sciomer S, Cavallaro G, Ciardi A, Massa R, De Toma G, Filetti S, Letizia C: Primary aldosteronism due to adrenocortical adenoma with concurrent ileum carcinoid tumor: case report. Endocrine; 2010 Dec;38(3):313-9
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary aldosteronism due to adrenocortical adenoma with concurrent ileum carcinoid tumor: case report.
  • Primary aldosteronism (PA) with synchronous carcinoid syndrome is extremely rare occurrence.
  • In this article, we describe a case of PA due to adrenocortical adenoma ("aldosteronoma") and concurrent malignant carcinoid tumor of ileum.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Carcinoid Tumor / complications. Hyperaldosteronism / complications. Hyperaldosteronism / etiology. Ileal Neoplasms / complications


14. Eloy-Garcia Carrasco C, Benguigui Benadiva J, Martinez Garcia S, Sanz Trelles A, Palacios S: Atypical primary carcinoid tumour of the skin. J Cutan Pathol; 2006 Sep;33 Suppl 2:32-4
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical primary carcinoid tumour of the skin.
  • We present a new case of a primary carcinoid tumour of the skin.
  • The mitotic index (4/10 HPF) warrants classification of this case as atypical.
  • Literature review showed this to be only the seventh case of primary carcinoid tumour of the skin.
  • Although the number of cases is too small to draw definitive conclusions, information to date suggests that this type of tumour can be expected to have a benign behaviour, despite the presence in some cases of criteria suggestive of uncertainty, such as the presence of mitosis.
  • [MeSH-major] Carcinoid Tumor / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972951.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 7
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15. Hubalewska-Dydejczyk A, Fröss-Baron K, Gołkowski F, Sowa-Staszczak A, Mikołajczak R, Huszno B: 99mTc-EDDA/HYNIC-octreotate in detection of atypical bronchial carcinoid. Exp Clin Endocrinol Diabetes; 2007 Jan;115(1):47-9
Hazardous Substances Data Bank. DISODIUM CALCIUM EDTA .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 99mTc-EDDA/HYNIC-octreotate in detection of atypical bronchial carcinoid.
  • We present a case of a 40-year-old women operated on because of lung carcinoid tumour in 2002.
  • Owing to severe bone pains and carcinoid symptoms the patient was referred for the 90Y-DOTA-octreotate treatment.
  • CONCLUSIONS: SRS with a new 99mTc marked somatostatin analogue - octreotate allows for a more sensitive detection of metastatic leasions in carcinoid tumours.
  • The usefulness of 18F-FDG PET, widely used as a powerful imaging technique in clinical oncology, is limited in detection of carcinoid tumours due to the low proliferative activity.
  • [MeSH-major] Carcinoid Tumor / radiography. Lung Neoplasms / radiography. Mediastinal Neoplasms / radiography. Radiopharmaceuticals / administration & dosage

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  • Hazardous Substances Data Bank. ETHYLENEDIAMINE TETRAACETIC ACID .
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  • (PMID = 17286235.001).
  • [ISSN] 0947-7349
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 6-hydrazinopyridine-3-carboxylic acid; 0 / Hydrazines; 0 / Nicotinic Acids; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 51110-01-1 / Somatostatin; 5657-17-0 / EDDA; 9G34HU7RV0 / Edetic Acid; G083B71P98 / pentetreotide
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16. Davies-Husband CR, Montgomery P, Premachandra D, Hellquist H: Primary, combined, atypical carcinoid and squamous cell carcinoma of the larynx: a new variety of composite tumour. J Laryngol Otol; 2010 Feb;124(2):226-9
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

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  • [Title] Primary, combined, atypical carcinoid and squamous cell carcinoma of the larynx: a new variety of composite tumour.
  • OBJECTIVE: We report the first case of a laryngeal composite tumour consisting of a squamous cell carcinoma combined with an atypical carcinoid.
  • Primary neuroendocrine neoplasms represent a rare, heterogeneous subset of laryngeal malignancies, comprising typical carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma.
  • Primary combined neuroendocrine and squamous cell carcinoma of the larynx is even more rarely encountered, with only 14 publications of this so-called composite tumour to date.
  • CONCLUSION: The treatment of primary neoplasms comprising more than one histological type is tailored to the most biologically aggressive tumour.
  • Accurate diagnosis of the histological nature of laryngeal composite tumours is imperative to ensure optimal therapy.
  • [MeSH-major] Carcinoid Tumor / pathology. Carcinoma, Squamous Cell / pathology. Laryngeal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19930775.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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17. García-Yuste M, Matilla JM, Cueto A, Paniagua JM, Ramos G, Cañizares MA, Muguruza I, Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung for the Spanish Society of Pneumonology and Thoracic Surgery (EMETNE-SEPAR): Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung. Eur J Cardiothorac Surg; 2007 Feb;31(2):192-7
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  • [Title] Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung.
  • BACKGROUND: This study examines the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung with patients treated surgically for typical and atypical carcinoid tumours.
  • METHODS: From 1980 to 2002, 661 patients were treated surgically for 569 typical carcinoid tumours and 92 atypical carcinoid tumours.
  • Three hundred and four cases were studied retrospectively from 1980 to 1997 (261 typical carcinoid and 43 atypical carcinoid tumours); the other 357 new cases (308 typical carcinoid and 49 atypical carcinoid tumours) were collected prospectively from 1998 to 2002.
  • RESULTS: In the total of the patients, 5-year survival for different tumours was as follows: typical carcinoid: overall survival 97%; with nodal involvement 100%; atypical carcinoid: overall 78%; with nodal involvement 60%.
  • A significant difference in survival was found between patients in the retrospective and prospective groups with atypical carcinoid and nodal involvement.
  • The comparative analysis of several factors in typical and atypical carcinoid tumours showed a significant difference for mean age, tumour size, nodal involvement and distant metastases.
  • Sleeve resection could be performed in central typical and atypical carcinoid tumours, avoiding pneumonectomy.
  • [MeSH-major] Carcinoid Tumor / surgery. Lung Neoplasms / surgery

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  • (PMID = 17196822.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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18. Dutta R, Kumar A, Julka PK, Mathur SR, Kaushal S, Kumar R, Jindal T, Suri V: Thymic neuroendocrine tumour (carcinoid): clinicopathological features of four patients with different presentation. Interact Cardiovasc Thorac Surg; 2010 Dec;11(6):732-6
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  • [Title] Thymic neuroendocrine tumour (carcinoid): clinicopathological features of four patients with different presentation.
  • This article describes the utility of (68)Gallium-1,4,7,10-traazacyclododecane-NI, NII, NIII, NIIII-tetra acetic acid-(D)-Phel1-Tyr3-octreotide positron emission tomography ((68)Ga DOTATOC PET-CT-scan) and clinicopathological features of four thymic carcinoid tumours.
  • Two typical, one atypical, and one large cell neuroendocrine carcinoma (LCNEC) were analysed.
  • Three patients had a stage III and one had a stage II tumour.
  • Preoperative (68)Ga DOTATOC PET-CT-scan of three patients did not show uptake of radiotracer in the tumour.
  • There is no locoregional recurrence of tumour in any of our patients.
  • Complete surgical resection of the tumour with invaded adjacent structures, postoperative radiotherapy to the tumour bed helps in obtaining disease free survival.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Octreotide / analogs & derivatives. Organometallic Compounds. Positron-Emission Tomography. Radiopharmaceuticals. Thymus Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 20851876.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ga(III)-DOTATOC; 0 / Organometallic Compounds; 0 / Radiopharmaceuticals; RWM8CCW8GP / Octreotide
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19. Karavolos S, Caplin M, Benjamin E, Crow J, Mould T: Primary mucinous carcinoid tumour of the ovary: a case report. Eur J Gynaecol Oncol; 2006;27(6):618-20
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  • [Title] Primary mucinous carcinoid tumour of the ovary: a case report.
  • Primary ovarian carcinoid tumours of the ovary are rare and represent less than 0.1% of ovarian malignancy.
  • We report a case of primary ovarian mucinous carcinoid tumour, of the atypical category, in a 34-year-old nulliparous woman.
  • This case adds to the body of evidence and demonstrates a possible good prognosis with non-aggressive behaviour in the atypical mucinous carcinoid group.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoid Tumor / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Leiomyoma / diagnosis. Prognosis. Treatment Outcome

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  • (PMID = 17290597.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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20. Kuczma JA, Grzywa M: [Broncho-pulmonary carcinoid with the cardiac arrhythmia manifestation]. Pol Arch Med Wewn; 2006 Oct;116(4):971-3
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  • [Title] [Broncho-pulmonary carcinoid with the cardiac arrhythmia manifestation].
  • We are presenting the case of a 60-year-old woman (OM ) with a bronchial-pulmonary carcinoid which the only, first and dominating symptom was paroxysmal atrial tachycardia, as well as ventricular group extrasystoles.
  • The patient underwent urgent surgery after an episode of massive pulmonary haemorrhage--surgery included excision of the upper lobe of the left lung containing the tumour and mediastinal lymph nodes.
  • On microscopic examination, an atypical carcinoid was diagnosed.
  • The current imaging examinations and determinations of 5-HIO uringexcretion acid do not indicate relapse of the tumour.
  • [MeSH-major] Arrhythmias, Cardiac / etiology. Bronchial Neoplasms / complications. Carcinoid Tumor / complications. Lung Neoplasms / complications

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  • (PMID = 18416299.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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21. Bapat U, Mackinnon NA, Spencer MG: Carcinoid tumours of the larynx. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):194-7
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  • [Title] Carcinoid tumours of the larynx.
  • They can be divided into typical, atypical and small cell tumours on the basis of their histopathological differentiation.
  • The tumour histology and prognosis correlate closely.
  • The typical carcinoid tumours are well differentiated with a benign course.
  • The atypical carcinoid tumours are poorly differentiated with an aggressive course.
  • We present two cases with similar history and clinical findings-one typical and the other atypical-and discuss the relevant literature.
  • [MeSH-major] Carcinoid Tumor / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 15164214.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Rizzardi G, Marulli G, Calabrese F, Rugge M, Rebusso A, Sartori F, Rea F: Bronchial carcinoid tumours in children: surgical treatment and outcome in a single institution. Eur J Pediatr Surg; 2009 Aug;19(4):228-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bronchial carcinoid tumours in children: surgical treatment and outcome in a single institution.
  • BACKGROUND: Carcinoid tumors are low grade, malignant, neuroendocrine neoplasms.
  • The aim of our study was to analyse the long-term survival and surgical treatment outcome in our young patients operated for carcinoid tumour.
  • There were 13 typical and 2 atypical carcinoids.
  • [MeSH-major] Bronchial Neoplasms / surgery. Carcinoid Tumor / surgery. Neoplasm Recurrence, Local / surgery

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  • [Copyright] Copyright Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 19513967.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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23. Vandist V, Deridder F, Waelput W, Parizel PM, Van de Heyning P, Van Laer C: A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report. B-ENT; 2010;6(2):147-51

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  • [Title] A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report.
  • Neuroendocrine tumours can be classified into typical carcinoids, atypical carcinoids and small cell neuroendocrine carcinomas.
  • Here we report the case of a 48-year-old man with a typical carcinoid tumour of the nasopharynx and sphenoid sinus.
  • This is a very rare diagnosis, and only a few cases of a typical carcinoid in this region have been described in the literature.
  • [MeSH-major] Carcinoma, Neuroendocrine / diagnosis. Nasopharyngeal Neoplasms / diagnosis. Paranasal Sinus Neoplasms / diagnosis. Sphenoid Sinus

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  • (PMID = 20681371.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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24. Berndt A, Köllner R, Richter P, Franz M, Voigt A, Berndt A, Borsi L, Giavazzi R, Neri D, Kosmehl H: A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies. Histochem Cell Biol; 2010 Apr;133(4):467-75
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  • [Title] A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies.
  • Tumour angioneogenesis is associated with the reexpression of oncofetal fibronectin (oncFn) and tenascin-C (oncTn-C) splice variants, which may serve as targets for antibody-based pharmacodelivery.
  • Knowledge of the vascular distribution and organization in different tumours is of importance for the understanding of tumour vessel formation and might be crucial for therapy.
  • Renal cell carcinomas and atypical carcinoid of the lung revealed vessel-restricted oncFn and/or oncTn-C depositions; all other entities showed a variable stroma positivity including vessels.
  • The individual pattern of oncFn/oncTn-C incorporation in the vBM depended on tumour type, vessel size and intratumoural heterogeneity.
  • In conclusion, tumours differ in the pattern of Fn or Tn-C isoform positivity in the vessel wall, potentially representing a tumour type specific endothelial cell-tumour cell-stromal cell interaction.

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  • (PMID = 20237793.001).
  • [ISSN] 1432-119X
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fibronectins; 0 / Laminin; 0 / Protein Isoforms; 0 / Tenascin; 0 / oncofetal fibronectin
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25. Kiratli H, Yilmaz PT, Yildiz ZI: Metastatic atypical carcinoid tumor of the inferior rectus muscle. Ophthal Plast Reconstr Surg; 2008 Nov-Dec;24(6):482-4
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  • [Title] Metastatic atypical carcinoid tumor of the inferior rectus muscle.
  • A 74-year-old man who had been treated for pulmonary atypical carcinoid tumor 3 years earlier developed diplopia.
  • Incisional biopsy of the affected muscle revealed metastatic atypical carcinoid tumor infiltration that immunostained positively for epithelial membrane antigen, synaptophysin, and chromogranin.
  • Systemic chemotherapy consisting of cisplatin and etoposide was prescribed to address the orbital tumor and a contemporaneously discovered hepatic locus.
  • Although metastatic bronchogenic carcinoid tumor in the orbit, and in the inferior rectus muscle in particular, is highly unusual, this condition must be considered in the differential diagnosis of an isolated extraocular muscle enlargement in a patient with a history of systemic carcinoid tumor.
  • [MeSH-major] Carcinoid Tumor / secondary. Eye Neoplasms / secondary. Lung Neoplasms / pathology. Muscle Neoplasms / secondary. Oculomotor Muscles
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19033849.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Jonnakuty CG, Mezitis SG: Pulmonary atypical carcinoid tumor with metastatic involvement of the pituitary gland causing functional hypopituitarism. Endocr Pract; 2007 May-Jun;13(3):291-5
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  • [Title] Pulmonary atypical carcinoid tumor with metastatic involvement of the pituitary gland causing functional hypopituitarism.
  • OBJECTIVE: To report a unique case of a peripherally located pulmonary atypical carcinoid tumor with metastatic involvement of the pituitary, manifesting with evidence of functional hypopituitarism and compressive symptoms of dysarthria, bitemporal loss of vision, and ataxia.
  • METHODS: We present a case report, including detailed laboratory, radiologic, and pathologic findings in a 50-year-old woman with a peripherally located pulmonary atypical carcinoid tumor and a lesion metastatic to the pituitary gland.
  • RESULTS: A 50-year-old woman with a medical history of metastatic pulmonary atypical carcinoid tumor presented with symptoms of bitemporal hemianopia, ataxia, and dysarthria.
  • Findings on pathology examination were consistent with a lesion metastatic from the primary pulmonary atypical carcinoid tumor.
  • CONCLUSION: This case of metastatic involvement of the pituitary gland from a peripherally located pulmonary atypical carcinoid tumor manifesting with evidence of functional hypopituitarism is highly uncommon.
  • Therefore, heightened awareness of the possibility of a pituitary lesion metastatic from a pulmonary atypical carcinoid tumor is important.
  • [MeSH-major] Carcinoid Tumor / complications. Hypopituitarism / etiology. Lung Neoplasms / complications. Pituitary Neoplasms / complications

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  • (PMID = 17599862.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Isaka T, Maruno M, Suzuki T, Sato M, Yoshimine T: Skull metastases from atypical pulmonary carcinoid tumor in a 19-year-old man. Neurol Med Chir (Tokyo); 2006 Dec;46(12):609-13
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  • [Title] Skull metastases from atypical pulmonary carcinoid tumor in a 19-year-old man.
  • A 19-year-old man presented with a rare skull metastasis from atypical pulmonary carcinoid tumor (APCT) manifesting as headache, diplopia, and cough.
  • Head magnetic resonance imaging showed a skull base tumor extending from the posterior clinoid process to the clivus, and calvarial tumors in the right temporal and occipital bones.
  • Chest and abdominal computed tomography showed a round tumor, 4 cm in diameter, in the lower lobe of the right lung and multiple small tumors in the liver.
  • Surgery for the calvarial tumor in the right temporal bone was performed on June 27, 2003.
  • The histological diagnosis was skull metastasis of neuroendocrine tumor.
  • Partial resection of the right lower lobe was performed for the lung tumor on August 22, 2003.
  • The histological diagnosis was atypical carcinoid tumor.
  • We must consider APCT in the differential diagnosis of pulmonary tumors in adolescents, and perform follow-up observation or treatment, including surgery, if APCT is suspected.
  • [MeSH-major] Carcinoid Tumor / secondary. Lung Neoplasms / pathology. Skull Neoplasms / secondary

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  • (PMID = 17185889.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Simsek I, Pay S, Dinc A, Erdem H, Kurt B: Atypical carcinoid tumor of the thymus with ectopic ACTH production developed during the course of etanercept treatment--case report. Clin Rheumatol; 2007 Sep;26(9):1561-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical carcinoid tumor of the thymus with ectopic ACTH production developed during the course of etanercept treatment--case report.
  • Ever since the introduction of anti-tumor necrosis factor (TNF) agents, concerns have been raised regarding their potential for developing malignancy.
  • We report the development of thymic atypical carcinoid tumor 9 months after the initiation of etanercept therapy in a patient having refractory spondylarthritis.
  • [MeSH-major] Antibodies, Monoclonal / adverse effects. Carcinoid Tumor / chemically induced. Immunoglobulin G / adverse effects. Thymus Neoplasms / chemically induced. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Adult. Etanercept. Humans. Male. Pituitary ACTH Hypersecretion / etiology. Receptors, Tumor Necrosis Factor. Spondylarthritis / drug therapy

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  • (PMID = 17061154.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
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29. Yao T: [Clinicopathological features of small intestinal tumors]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1436-9

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  • Comparatively frequent malignant lesions are carcinoma, carcinoid tumor, malignant lymphoma, and GIST (gastrointestinal stromal tumor).
  • The prognosis of small intestinal cancer is poor, because preoperative diagnosis is difficult and it is usually discovered at the advanced stage.
  • The incidence of carcinoid tumor is lower in Japan than in Western countries.
  • Among malignant lymphomas of the small intestine, the incidence of MALT lymphoma is lower, and those of T cell and follicular ones are higher than in the stomach.
  • Lymphomas with minimal cellular atypia are often encountered, and in such cases biopsy diagnosis is difficult.
  • The prognosis of malignant small intestinal disease will improve through early diagnosis with the recent progress in the procedures for detecting small intestinal disease.
  • [MeSH-minor] Carcinoid Tumor / pathology. Gastrointestinal Stromal Tumors / pathology. Humans. Lymphoma / pathology. Prognosis

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  • (PMID = 20716865.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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30. Chang KP, Lee LY, Yeh AR, Dai TS, Hao SP: Endoscopic CO2 laser surgery for an atypical carcinoid tumor of the epiglottis masquerading as a supraglottic cyst. Head Neck; 2005 Nov;27(11):1004-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic CO2 laser surgery for an atypical carcinoid tumor of the epiglottis masquerading as a supraglottic cyst.
  • BACKGROUND: Atypical carcinoid tumor is a neuroendocrine tumor; its occurrence in the larynx is uncommon, and clinical manifestations are rare.
  • We report an unusual case of atypical carcinoid tumor of the epiglottis mimicking a supraglottic retention cyst.
  • Her symptoms persisted, so we performed a laryngoscopic biopsy, which suggested an atypical carcinoid tumor.
  • Endoscopic CO2 laser surgery can be used to resect this uncommon tumor, with oncologically sound results and without surgical morbidity.
  • [MeSH-major] Carcinoid Tumor / surgery. Epiglottis / surgery. Laryngeal Neoplasms / surgery. Laser Therapy / methods
  • [MeSH-minor] Adult. Cysts / diagnosis. Diagnosis, Differential. Female. Humans. Laryngeal Diseases / diagnosis. Treatment Outcome

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 16114009.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Senda E, Fujimoto K, Ohnishi K, Higashida A, Ashida C, Okutani T, Sakano S, Yamamoto M, Ito R, Yamada H: Minute ampullary carcinoid tumor with lymph node metastases: a case report and review of literature. World J Surg Oncol; 2009;7:9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minute ampullary carcinoid tumor with lymph node metastases: a case report and review of literature.
  • BACKGROUND: Carcinoid tumors are usually considered to have a low degree of malignancy and show slow progression.
  • One of the factors indicating the malignancy of these tumors is their size, and small ampullary carcinoid tumors have been sometimes treated by endoscopic resection.
  • CASE PRESENTATION: We report a case of a 63-year-old woman with a minute ampullary carcinoid tumor that was 7 mm in diameter, but was associated with 2 peripancreatic lymph node metastases.
  • Endoscopy showed that the ampulla was slightly enlarged by a submucosal tumor.
  • The biopsy specimen revealed tumor cells that showed monotonous proliferation suggestive of a carcinoid tumor.
  • The resected lesion was a small submucosal tumor (7 mm in diameter) at the ampulla, with metastasis to 2 peripancreatic lymph nodes, and it was diagnosed as a malignant carcinoid tumor.
  • CONCLUSION: Recently there have been some reports of endoscopic ampullectomy for small carcinoid tumors.
  • However, this case suggests that attention should be paid to the possibility of lymph node metastases as well as that of regional infiltration of the tumor even for minute ampullary carcinoid tumors to provide the best chance for cure.
  • [MeSH-major] Ampulla of Vater. Carcinoid Tumor / secondary. Common Bile Duct Neoplasms / pathology

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  • [Cites] J Gastrointest Surg. 2008 Apr;12(4):713-7 [17992565.001]
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  • (PMID = 19159493.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2636813
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32. Davì MV, Bodei L, Francia G, Bartolomei M, Oliani C, Scilanga L, Reghellin D, Falconi M, Paganelli G, Lo Cascio V, Ferdeghini M: Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). J Endocrinol Invest; 2006 Jun;29(6):563-7
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  • [Title] Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid).
  • It is well known that some procedures performed in diagnostic and therapeutic management of endocrine tumors, such as agobiopsy and hepatic chemoembolization, can be associated with the occurrence of symptoms related to the release of vasoactive amines and/or hormonal peptides from tumor cell lysis.
  • This is the first report of a severe carcinoid crisis developed after receptor radionuclide therapy with 90Y-DOTATOC administered in a patient affected by liver metastases from bronchial neuroendocrine tumor (atypical carcinoid).
  • [MeSH-major] Bronchial Neoplasms / pathology. Liver Neoplasms / secondary. Malignant Carcinoid Syndrome / chemically induced. Octreotide / analogs & derivatives
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Carcinoid Tumor / drug therapy. Carcinoid Tumor / radiotherapy. Humans. Male. Yttrium Radioisotopes / adverse effects

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  • (PMID = 16840837.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / 90Y-octreotide, DOTA-Tyr(3)-; 0 / Yttrium Radioisotopes; RWM8CCW8GP / Octreotide
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33. Hsu TC: Intra-abdominal lesions could be missed by inadequate laparoscopy. Am Surg; 2008 Sep;74(9):824-6; discussion 827-8
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  • Eleven patients were found to have synchronous colorectal cancers; five patients were found to have unexpected liver metastases; three patients each were found to have gastric cancers, stromal tumors of the small bowel, and ectopic pancreas; two patients each were found to have gastric leiomyosarcomas, pancreatic cancers, mucoceles of the appendix, ulcers of the small intestine, bleeding Meckel's diverticula, pancreatitis, and perforations of the ileum; one patient each was found to have gall bladder cancer, malignant carcinoid tumor, pheochromocytoma, diverticulitis of the jejunum, diverticulitis of the colon, duplication of the colon, and aortic aneurysm larger than 6 cm.
  • [MeSH-major] Digestive System Diseases / diagnosis. Laparoscopy

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  • (PMID = 18807670.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Ferlito A, Devaney KO, Rinaldo A: Neuroendocrine neoplasms of the larynx: advances in identification, understanding, and management. Oral Oncol; 2006 Sep;42(8):770-88
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  • While 85-90% of laryngeal malignancies prove to be squamous carcinomas, the second most common tumour type found in the laryngeal region will prove to be a member of the family of neuroendocrine tumours.
  • Laryngeal carcinoid tumours have a capacity for metastasis, and so are more aggressive tumours than their light microscopic features might imply--5-year survival rates are in the vicinity of 50%.
  • Laryngeal atypical carcinoid tumours are lesions with a well-recognized capacity for local recurrence as well as metastasis, with a 5-year survival of just under 50%.
  • Surgical excision is the mainstay of treatment of carcinoid tumours, atypical carcinoid tumours, and paragangliomas.
  • Small cell neuroendocrine carcinomas are chiefly treated by way of radiation and chemotherapy; the role of adjuvant therapy in the treatment of atypical carcinoid tumours remains to be established.
  • [MeSH-major] Laryngeal Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Diagnosis, Differential. Humans. Paraganglioma / diagnosis. Paraganglioma / surgery. Prognosis

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  • (PMID = 16815077.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 457
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35. Srirajaskanthan R, Toumpanakis C, Karpathakis A, Marelli L, Quigley AM, Dusmet M, Meyer T, Caplin ME: Surgical management and palliative treatment in bronchial neuroendocrine tumours: a clinical study of 45 patients. Lung Cancer; 2009 Jul;65(1):68-73
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  • Histological diagnosis from our department was available for 39 patients, with the remainder having had histological assessment performed previously.
  • Typical carcinoid was present in 25 cases, atypical in 9 cases, large cell neuroendocrine carcinoma in 4 and 1 case of small cell lung carcinoma.
  • All patients were staged at time of initial diagnosis with CT scan, in addition Octreoscans were performed when appropriate.
  • Somatostatin analogues were used as first line therapy in six patients, for symptom control and anti-tumour effect.
  • [MeSH-major] Bronchial Neoplasms / therapy. Carcinoid Tumor / therapy. Palliative Care / methods

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  • (PMID = 19070398.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
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36. Zynger DL, Dimov ND, Ho LC, Laskin WB, Yeldandi AV: Differential expression of neural-cadherin in pulmonary epithelial tumours. Histopathology; 2008 Feb;52(3):348-54
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  • AIMS: Neural (N)-cadherin belongs to a group of transmembrane molecules with a crucial role in tissue morphogenesis and maintenance of an epithelioid phenotype and increased N-cadherin expression is implicated in tumour progression and dedifferentiation.
  • METHODS AND RESULTS: One hundred and fifty-five pulmonary lesions were analysed for N-cadherin expression using immunohistochemistry, including neuroendocrine hyperplasia (n = 3), typical carcinoid (n = 59), atypical carcinoid (n = 12), small cell lung carcinoma (n = 11), large cell neuroendocrine carcinoma (n = 12), adenocarcinoma (n = 35) and squamous cell carcinoma (n = 23).
  • N-cadherin expression was demonstrated in all cases of neuroendocrine hyperplasia, 96% of typical carcinoids, 83% of atypical carcinoids, 63% of the small cell lung carcinomas and 32% of large cell neuroendocrine carcinomas.
  • DISCUSSION: N-cadherin is differentially expressed in pulmonary tumours and is predominantly observed in neuroendocrine lung lesions with high expression in typical and atypical pulmonary carcinoids.
  • The level of expression of N-cadherin between types of lung tumours does not appear to indicate malignant potential or aggressive behaviour.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoid Tumor / metabolism. Carcinoid Tumor / secondary. Carcinoid Tumor / surgery. Carcinoma, Neuroendocrine / metabolism. Carcinoma, Neuroendocrine / pathology. Carcinoma, Neuroendocrine / surgery. Carcinoma, Small Cell / metabolism. Carcinoma, Small Cell / secondary. Carcinoma, Small Cell / surgery. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Fluorescent Antibody Technique, Direct. Humans. Hyperplasia. Immunoenzyme Techniques. Neurosecretory Systems / metabolism. Neurosecretory Systems / pathology

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  • (PMID = 18269586.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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37. Cardillo G, Treggiari S, Paul MA, Carleo F, De Massimi AR, Remotti D, Graziano P, Martelli M: Primary neuroendocrine tumours of the thymus: a clinicopathologic and prognostic study in 19 patients. Eur J Cardiothorac Surg; 2010 Apr;37(4):814-8
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  • METHODS: From January 1990 to December 2004, 19 patients (14 males, 5 females; mean age 48.6 years) were surgically treated for a primary neuroendocrine tumour of the thymus.
  • The 10-year survival was evaluated according to histology (typical carcinoid 100%; atypical carcinoid: 66.6%; large cell neuroendocrine tumours: 0%), Masaoka staging (stage I: 100%; stage II: 50%; stage III: 66.6%; stage IV: 0%), presence of paraneoplastic syndrome (no: 87.5%; yes: 0%) and postoperative radiotherapy (yes: 40%; no: 83.3%).
  • [MeSH-minor] Adult. Aged. Carcinoid Tumor / complications. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Paraneoplastic Syndromes / etiology. Prognosis. Reoperation. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
  • (PMID = 19954997.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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38. Granberg D, Wilander E, Oberg K: Expression of tyrosine kinase receptors in lung carcinoids. Tumour Biol; 2006;27(3):153-7
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  • In contrast, atypical carcinoids are more aggressive tumors, displaying metastases in up to 70%.
  • New therapies, such as inhibitors of the tyrosine kinase receptor family c-kit, platelet-derived growth factor receptors (PDGFR) alpha and beta and epidermal growth factor receptor (EGFR) have shown promising results in other malignancies and might be of value in malignant lung carcinoids.
  • PATIENTS AND METHODS: Tumor tissue from 51 patients with typical lung carcinoids were immunostained with polyclonal antibodies against c-kit, PDGFRalpha, PDGFRbeta and EGFR.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis. Receptor Protein-Tyrosine Kinases / analysis

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  • (PMID = 16612146.001).
  • [ISSN] 1010-4283
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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39. Rizvi SM, Goodwill J, Lim E, Yap YK, Wells AU, Hansell DM, Davis P, Selim AG, Goldstraw P, Nicholson AG: The frequency of neuroendocrine cell hyperplasia in patients with pulmonary neuroendocrine tumours and non-neuroendocrine cell carcinomas. Histopathology; 2009 Sep;55(3):332-7
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  • METHODS AND RESULTS: Random blocks without tumour from resected typical carcinoids (TCs, n = 46), atypical carcinoids (ACs, n = 14), large cell neuroendocrine carcinomas (LCNECs, n = 18), small cell carcinomas (SCLCs, n = 22), adenocarcinomas (ADENOs, n = 26) and squamous cell carcinomas (SCCs, n = 18) were stained for CD56 and evaluated for linear proliferations, cell aggregates (>4 CD56+ cells), and tumourlets (<5 mm with basement membrane invasion).
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoid Tumor / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / pathology. Precancerous Conditions
  • [MeSH-minor] Adult. Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Cell Proliferation. Female. Humans. Hyperplasia. Lung / pathology. Lung / physiopathology. Male. Middle Aged. Neuroendocrine Cells / metabolism. Neuroendocrine Cells / pathology. Respiratory Function Tests. Young Adult

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  • [ErratumIn] Histopathology. 2011 Apr;58(5):809. Abdel-Ghani, Syed [corrected to Selim, Abdel-Ghani]
  • (PMID = 19723148.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor
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40. Gomard-Mennesson E, Sève P, De La Roche E, Collardeau-Frachon S, Lombard-Bohas C, Broussolle C: [Thymic carcinoid tumor revealed by a Cushing's syndrome: usefulness of positron emission tomography]. Rev Med Interne; 2008 Sep;29(9):751-3
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  • [Title] [Thymic carcinoid tumor revealed by a Cushing's syndrome: usefulness of positron emission tomography].
  • Ectopic adrenocorticotropic (ACTH) syndrome is a rare condition, generally due to lung or carcinoid tumors.
  • A thymic tumor was suspected and the patient had a thymectomy that revealed an atypical carcinoid tumor with pleural carcinosis.


41. Bode-Lesniewska B, Hodler J, von Hochstetter A, Guillou L, Exner U, Caduff R: Late solitary bone metastasis of a primary pulmonary synovial sarcoma with SYT-SSX1 translocation type: case report with a long follow-up. Virchows Arch; 2005 Mar;446(3):310-5
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  • We describe a 73-year-old female patient who presented with a solitary malignant bone tumor 8 years after the resection of a lung neoplasm.
  • The bone tumor was classified as an osteosarcoma and the lung tumor as an atypical carcinoid tumor at their first respective diagnostic work-ups.
  • Reevaluation of the tumor samples at the time of the local recurrence of the bone tumor 6 years following the initial symptoms of the bone tumor lead to the reclassification of both specimens as synovial sarcomas.
  • [MeSH-minor] Aged. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Oncogene Proteins, Fusion. Osteosarcoma / pathology. Reverse Transcriptase Polymerase Chain Reaction. Time Factors. Translocation, Genetic

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  • (PMID = 15668803.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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42. Blochin E, Stein JA, Wang NS: Atypical carcinoid metastasis to the skin. Am J Dermatopathol; 2010 Oct;32(7):735-9
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  • [Title] Atypical carcinoid metastasis to the skin.
  • Carcinoid tumors are derived from neuroendocrine cells, and are most frequently found in the gastrointestinal tract and bronchopulmonary system.
  • Cutaneous involvement of carcinoid tumors is relatively rare, with isolated case reports in the literature.
  • We detail a patient with stage IV pulmonary atypical carcinoid tumor with skin metastasis.
  • On biopsy, the tumor cells had cytologic features of a carcinoid tumor, but were arranged as infiltrating cords, small aggregates and single units, rather than the organoid or trabecular pattern seen in the primary tumor.
  • Further, along with neuroendocrine markers, the tumor cells had the staining pattern of cytokeratin 7+/cytokeratin 20-/thyroid transcription factor-1+, supporting a carcinoid tumor of lung origin.
  • Thus, this case of skin metastasis from an atypical pulmonary carcinoid tumor illustrates a unique clinical and histologic presentation.
  • [MeSH-major] Carcinoid Tumor / secondary. Lung Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 20595888.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Kasprzak A, Olejniczak K, Przybyszewska W, Zabel M: Cellular expression of interleukin 2 (IL-2) and its receptor (IL-2R, CD25) in lung tumours. Folia Morphol (Warsz); 2007 Aug;66(3):159-66
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  • The immunocytochemical ABC technique was applied to archival tissue material of neuroendocrine lung tumours: lung carcinoids, including typical carcinoids (TC), atypical carcinoids (AC) and small-cell lung cancers (SCLC) and squamous cell lung cancers (non-small cell lung cancers, NSCLC).
  • The highest frequency of IL-2 expression (93%) was noted and the most pronounced semi-quantitatively evaluated expression of IL-2 was detected in AC tumour cells.
  • The results suggest a negative correlation between IL-2 expression and the proliferative activity of tumour cells (evaluated by expression of Ki-67) in AC.
  • Semi-quantitative expression of IL-2R, like that of IL-2, also dominated in the group of atypical lung carcinoids but manifested a significant difference only as compared to typical carcinoids (p = 0.014).
  • [MeSH-major] Carcinoid Tumor / metabolism. Carcinoma, Small Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Interleukin-2 / metabolism. Interleukin-2 Receptor alpha Subunit / metabolism. Lung Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Proliferation. Gene Expression Regulation, Neoplastic. Humans. Ki-67 Antigen / metabolism. Prognosis

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  • (PMID = 17985312.001).
  • [ISSN] 0015-5659
  • [Journal-full-title] Folia morphologica
  • [ISO-abbreviation] Folia Morphol. (Warsz)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Interleukin-2; 0 / Interleukin-2 Receptor alpha Subunit; 0 / Ki-67 Antigen
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44. O'Gorman T, Olaitan A: Primary malignant melanoma arising in an ovarian cystic teratoma. Eur J Gynaecol Oncol; 2009;30(1):88-9
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  • [Title] Primary malignant melanoma arising in an ovarian cystic teratoma.
  • Malignant melanoma developing in a teratoma, however, is an extremely rare diagnosis.
  • She underwent laparotomy and bilateral salpingo-oophorectomy for a large right ovarian tumour.
  • Histopathology revealed a malignant melanoma and carcinoid tumour in the right ovarian teratoma and an endometrioid adenocarcinoma in the left ovary.
  • Subsequent vaginal hysterectomy revealed complex atypical hyperplasia in the endometrium.

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  • (PMID = 19317266.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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45. Olgac G, Peirovi F, Yilmaz A, Kutlu CA: Giant carcinoid tumor mimicking pulmonary sequestration. Ann Thorac Surg; 2007 Oct;84(4):1375-6
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  • [Title] Giant carcinoid tumor mimicking pulmonary sequestration.
  • Then a right lower lobectomy was undertaken through a hemi-clamshell incision, and histopathology revealed an atypical carcinoid tumor.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchopulmonary Sequestration / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adult. Biopsy, Needle. Bronchoscopy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Pneumonectomy / methods. Reoperation. Risk Assessment. Severity of Illness Index. Treatment Outcome

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  • (PMID = 17889003.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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46. Stoll LM, Johnson MW, Burroughs F, Li QK: Cytologic diagnosis and differential diagnosis of lung carcinoid tumors a retrospective study of 63 Cases with histologic correlation. Cancer Cytopathol; 2010 Dec 25;118(6):457-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic diagnosis and differential diagnosis of lung carcinoid tumors a retrospective study of 63 Cases with histologic correlation.
  • BACKGROUND: Neuroendocrine (NE) neoplasms of the lung are a spectrum of tumors including typicalcarcinoid (TC), atypical carcinoid tumor (ACT), small cell lung carcinoma (SCLC), and large cell NEcarcinoma (LCNEC).
  • CONCLUSIONS: The significant morphologic factors for distinguishing low-grade TC from ACT, SCLC, or carcinoma remain the critical evaluation of nuclear features, chromatin patterns, and assessment of nucleoli.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 21243734.001).
  • [ISSN] 1934-662X
  • [Journal-full-title] Cancer cytopathology
  • [ISO-abbreviation] Cancer Cytopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Spaggiari L, D' Aiuto M, Veronesi G, Pelosi G, de Pas T, Catalano G, de Braud F: Extended pneumonectomy with partial resection of the left atrium, without cardiopulmonary bypass, for lung cancer. Ann Thorac Surg; 2005 Jan;79(1):234-40
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  • The were 10 squamous cell carcinomas (60%), 2 adenocarcinomas, 1 adenosquamous carcinoma, 1 mucoepidermoid carcinoma, and 1 atypical carcinoid tumor.

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  • (PMID = 15620949.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 11
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48. Mahomed F: Neuroendocrine cells and associated malignancies of the oral mucosa: a review. J Oral Pathol Med; 2010 Feb;39(2):121-7
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  • Primary malignant oral tumors that show a neuroendocrine phenotype display histomorphologic heterogeneity thereby giving rise to a spectrum of lesions in this rare category of oral malignancy.
  • The former is further subdivided into the Merkel cell type or the pulmonary type while the latter includes atypical carcinoid tumor and large cell NEC.
  • It remains to be determined whether histologic categorization of the remaining tumor subtypes is predictive of patient survival in oral neuroendocrine tumors.

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  • (PMID = 20002872.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 53
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49. Graziani R, Brandalise A, Bellotti M, Manfredi R, Contro A, Falconi M, Boninsegna L, Pozzi Mucelli R: Imaging of neuroendocrine gastroenteropancreatic tumours. Radiol Med; 2010 Oct;115(7):1047-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The role of imaging in functioning endocrine tumours (FETs) is primarily to detect the tumour, that is, to verify lesion number and location.
  • Radiological detection of carcinoid tumours is limited by typical tumour location throughout the gastrointestinal tract or appendix and is therefore dependent on the tumour being large enough to make it recognisable in that site.
  • In the setting of nonfunctioning endocrine tumours (NFETs), which manifest late as large masses causing compression symptoms or as incidental findings, imaging is not primarily aimed at tumour detection, as this is relatively easy given the large size of the lesions.
  • Rather, its role is to characterise the tumour and, in particular, to differentiate pancreatic NFET from ductal adenocarcinoma, as in comparison, malignant NFETs have a more favourable prognosis (5-year survival rate 40% compared with 3%-5% for adenocarcinoma) and therefore require different treatment approaches.
  • As NFET are often malignant, they also require accurate staging and appropriate follow-up.
  • Some 20% of NFETs display different imaging characteristics ("atypical" appearance) as a result of arterial hypovascularity due to the presence of abundant fibrous stroma.
  • [MeSH-major] Intestinal Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis. Pancreatic Neoplasms / radiography. Stomach Neoplasms / diagnosis

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  • (PMID = 20221711.001).
  • [ISSN] 1826-6983
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
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50. Shimakage M, Kodama K, Kawahara K, Kim CJ, Ikeda Y, Yutsudo M, Inoue H: Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. Oncol Rep; 2009 Jun;21(6):1367-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.
  • Neuroendocrine tumors in the lung fall into four categories: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung carcinoma (SCLC), in ascending order of malignancy.
  • Furthermore, drs knockout mice showed a tumor-prone phenotype, indicating that drs acts as a tumor suppressor gene in malignant tumor formation.
  • Our results indicate that the downregulation of drs is correlated with the development of SCLC, a highly malignant pulmonary neuroendocrine tumor.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Lung Neoplasms / genetics. Membrane Proteins / genetics. Neuroendocrine Tumors / genetics
  • [MeSH-minor] Adult. Aged. Blotting, Southern. Carcinoid Tumor / genetics. Carcinoma, Large Cell / genetics. Carcinoma, Neuroendocrine / genetics. Cell Line, Tumor. Down-Regulation. Female. Humans. In Situ Hybridization. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Small Cell Lung Carcinoma / genetics

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  • (PMID = 19424611.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / SRPX protein, human
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51. Radfar L, Fatahzadeh M: Neuroendocrine carcinoma of the oral cavity: a case report and review of the literature. Gen Dent; 2008 Nov-Dec;56(7):714-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Based on their biological characteristics, NE carcinomas are classified into three subtypes: well-differentiated NE carcinoma (typical carcinoid tumor), moderately differentiated NE carcinoma (atypical carcinoid tumor), and poorly differentiated carcinoma (small cell carcinoma).

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  • (PMID = 19014033.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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52. Booij KA, van Eeden S, Ghazi Hosseini E, ten Kate FJ, Aronson DC: [An unusual presentation of a periappendicular infiltrate]. Ned Tijdschr Geneeskd; 2008 Sep 27;152(39):2133-7
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  • A 17-year-old boy presented with an atypical manifestation of acute appendicitis.
  • The clinical aspect, radiological investigations and peroperative aspect of the appendix were not conclusive but nevertheless a neuroendocrine tumour (carcinoid tumour) of the appendix was suspected.
  • After ileocaecal resection and resection of pathological lymph nodes, histopathological evaluation revealed the diagnosis: a periappendicular mass without any sign of malignancy.
  • [MeSH-minor] Abdominal Pain / etiology. Adolescent. Diagnosis, Differential. Humans. Male

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  • (PMID = 18856031.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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53. Cevizci R, Karakullukçu B, van den Brekel MW, Balm AJ: Laser excision of a typical carcinoid tumor of the larynx: a case report. Kulak Burun Bogaz Ihtis Derg; 2010 Nov-Dec;20(6):305-8
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  • [Title] Laser excision of a typical carcinoid tumor of the larynx: a case report.
  • Among these, typical carcinoid tumors are the least common type.
  • Prognosis of typical carcinoid tumor is better than atypical carcinoid tumor and small cell carcinoma of the larynx.
  • Fiberoptic examination of the larynx revealed a mass located on the right aryepiglottic fold and biopsy revealed the tumor as a typical carcinoid tumor.
  • We describe CO2 laser excision of a typical carcinoid tumor of the larynx in this case report.
  • [MeSH-major] Carcinoid Tumor / surgery. Laryngeal Neoplasms / surgery. Laser Therapy / methods

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  • (PMID = 20961285.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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54. Pagani A, Iandolo M: [Invasive breast carcinoma with features of neuroendocrine carcinoma and carcinoma with osteoclastic cells: fine-needle aspiration cytology and histology of two cases]. Pathologica; 2008 Jun;100(3):176-80
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  • Fine-needle aspiration cytology showed monomorphic, medium-sized, mildly atypical neoplastic cells, with interspersed multinucleated giant cells and lympho-histiocytic components; hemosiderin deposits were also appreciable.
  • Light microscopy revealed moderately differentiated invasive carcinoma mainly composed of solid sheets of round to polygonal medium-sized cells with a tendency to produce peripheral palisading (carcinoid-like morphology); osteoclast-like multinucleated giant cells, lymphocytes and histiocytes were dispersed only among tumour cells in the distinctive stroma of the carcinoma with osteoclastic giant cells; this stroma was characterised by reactive/fibroblastic features, hypervascularization, extravasated blood cells and hemosiderin deposits that gave rise to the typical staining seen macroscopically.
  • Both cases also had lymph node metastases; the epithelial neoplastic cells, with regards to neuroendocrine markers, were overlapping to the primitive tumour, the histiocytic/giant cell component appeared present, although with a lower degree, while the distinctive stroma was absent.

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  • (PMID = 18841823.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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55. Peng WX, Sano T, Oyama T, Kawashima O, Nakajima T: Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. Lung Cancer; 2005 Feb;47(2):225-33
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  • Large cell neuroendocrine carcinoma (LCNEC) of the lung is a malignant neuroendocrine tumor clinicopathologically similar to and falling in-between atypical carcinoid tumor and small cell lung carcinoma (SCLC).
  • The diagnosis of LCNEC is based mainly on a characteristic neuroendocrine morphology and biological neuroendocrine differentiation.

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  • (PMID = 15639721.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Retinoblastoma Protein; 68238-35-7 / Keratins
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56. Stathopoulos GP, Papadopoulos G, Koutantos J: Long-term survival of patients with carcinoid tumor and liver metastases. J BUON; 2009 Oct-Dec;14(4):609-11
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  • [Title] Long-term survival of patients with carcinoid tumor and liver metastases.
  • PURPOSE: To determine long-term survival and long-term stable disease in patients with atypical carcinoid tumor with liver metastases.
  • METHODS: From 1993 till 2008, the records of 56 patients with atypical carcinoid were reviewed.
  • All patients had carcinoid tumors confirmed histologically.
  • [MeSH-major] Carcinoid Tumor / mortality. Liver Neoplasms / mortality. Neoplasms / mortality

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  • (PMID = 20148450.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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57. Wang KL, Yang YC, Wang TY, Chen JR, Chen TC, Chen HS, Su TH, Wang KG: Neuroendocrine carcinoma of the uterine cervix: A clinicopathologic retrospective study of 31 cases with prognostic implications. J Chemother; 2006 Apr;18(2):209-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There are two cases of atypical carcinoid tumor (ACT), four cases of large-cell neuroendocrine carcinoma (LCNEC), and 25 cases of small-cell neuroendocrine carcinoma (SCNEC).
  • Overall survival did not differ significantly in relation to surgery, tumor histology, age, FIGO stages, chemotherapeutic regimens or lymph node involvement.
  • Effective treatments of neuroendocrine cervical tumor still remain inconclusive.
  • [MeSH-minor] Adult. Carcinoid Tumor / pathology. Carcinoid Tumor / virology. Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / virology. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / virology. Cervix Uteri / pathology. Cervix Uteri / virology. DNA Probes, HPV. Female. Human papillomavirus 16 / genetics. Human papillomavirus 16 / metabolism. Human papillomavirus 18 / genetics. Human papillomavirus 18 / metabolism. Humans. Middle Aged. Papillomaviridae / isolation & purification. Papillomavirus Infections / complications. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 16736891.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA Probes, HPV
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58. Ferlito A, Silver CE, Bradford CR, Rinaldo A: Neuroendocrine neoplasms of the larynx: an overview. Head Neck; 2009 Dec;31(12):1634-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the past, there has been considerable confusion about the nature and classification of these neoplasms, but the current consensus is that there are 4 different types of laryngeal neuroendocrine tumors composed of paraganglioma, typical carcinoid, atypical carcinoid tumor, and small cell neuroendocrine carcinoma.
  • Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry and electron microscopy.
  • Precise diagnosis is essential because the natural history, treatment, and prognosis vary widely for the different neoplastic categories.
  • Atypical carcinoid tumors are more common and more aggressive.
  • Small cell neuroendocrine carcinomas are highly aggressive and should be considered disseminated at initial diagnosis.
  • It is difficult to determine the valid survival statistics for typical carcinoids because of their rarity and confusion in the literature with their atypical counterparts.
  • Atypical carcinoid tumors have a 5-year survival rate of approximately 50%, which decreases with time.
  • [MeSH-minor] Carcinoid Tumor / mortality. Carcinoid Tumor / pathology. Carcinoid Tumor / therapy. Carcinoma, Small Cell / mortality. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / therapy. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Laryngectomy / methods. Male. Neck Dissection / methods. Neoplasm Staging. Paraganglioma / mortality. Paraganglioma / pathology. Paraganglioma / therapy. Prognosis. Radiotherapy, Adjuvant. Risk Assessment. Survival Analysis

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  • (PMID = 19536850.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 89
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59. Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM: Bronchopulmonary neuroendocrine tumors. Cancer; 2008 Jul 1;113(1):5-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although they share structural, morphological, immunohistochemical, and ultrastructural features, they are separated into 4 subgroups: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), large-cell neuroendocrine carcinoma (LCNEC), and small-cell lung carcinoma (SCLC), which exhibit considerably different biological characteristics.
  • Less than 5% of BP-NETs exhibit hormonally related symptoms such as carcinoid syndrome, Cushing, acromegaly, and SIADH.
  • The slow-growing TC exhibit a fairly good prognosis ( approximately 88%, 5-year survival), whereas AC demonstrate a 5-year survival of approximately 50%, and the highly malignant LCNEC and SCLC5-year survival of 15% to 57% and <5%, respectively.
  • [MeSH-minor] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / genetics. Bronchial Neoplasms / pathology. Bronchial Neoplasms / therapy. Carcinoid Tumor / diagnosis. Carcinoid Tumor / genetics. Carcinoid Tumor / pathology. Carcinoid Tumor / therapy. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / genetics. Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / therapy. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / genetics. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / therapy. Humans. Models, Biological. Neoplasm Metastasis. Prognosis

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  • [Copyright] (Copyright) 2008 American Cancer Society.
  • (PMID = 18473355.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 134
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60. Langfort R, Rudziński P, Burakowska B: [Pulmonary neuroendocrine tumors. The spectrum of histologic subtypes and current concept on diagnosis and treatment]. Pneumonol Alergol Pol; 2010;78(1):33-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pulmonary neuroendocrine tumors. The spectrum of histologic subtypes and current concept on diagnosis and treatment].
  • Neuroendocrine tumors of the lung represent a broad spectrum of morphologic types that share specific morphologic, immunohistochemical, ultrastructural, and molecular characteristics.
  • The classification of neuroendocrine lung tumors has changed over the last decades and currently four categories are distinguished: typical carcinoid tumor, atypical carcinoid tumor, large cell neuroendocrine carcinoma and small cell carcinoma.
  • Because of differences in clinical behavior, therapy, and prognosis, a reliable histological diagnosis, as well as clinical and pathological staging system are essential for an appropriate medical proceedings.
  • All carcinoids are malignant tumors with the potential to metastasize.
  • The majority of patients with pulmonary carcinoid have an excellent survival, even if they present with lymph node metastases.
  • Large cell neuroendocrine and small cell carcinoma progress rapidly and are generally widespread at the moment of diagnosis.
  • Increased knowledge about pulmonary neuroendocrine tumors biology and the genetic characteristics, imply that carcinoid tumors appear to have a different etiology and pathogenesis than large cell neuroendocrine and small cell carcinoma.
  • In practice, it could be easiest to conceptualize this group of pulmonary tumors as a spectrum of malignancy ranging from the low grade typical carcinoid to the highly malignant large cell neuroendocrine and small cell carcinoma.
  • Typical carcinoid tumors associated with a fairly benign behavior should be classified as low-grade neuroendocrine tumor/carcinoma (G1) and atypical carcinoid tumors as intermediate-grade tumor/carcinoma (G2).
  • Whereas, large cell neuroendocrine and small cell carcinoma should be grouped together under the designation of high-grade neuroendocrine tumor/carcinoma (G3).
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / therapy. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / therapy
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / therapy. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / therapy. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / therapy. Humans. Lung / pathology. Lymphatic Metastasis. Neoplasm Staging. Prognosis. Survival Analysis

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  • (PMID = 20162517.001).
  • [ISSN] 0867-7077
  • [Journal-full-title] Pneumonologia i alergologia polska
  • [ISO-abbreviation] Pneumonol Alergol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 67
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61. Wang WP, Guo C, Berney DM, Ulbright TM, Hansel DE, Shen R, Ali T, Epstein JI: Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2010 Apr;34(4):519-24
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  • [Title] Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases.
  • Testicular carcinoid tumors are rare with only limited studies.
  • We identified 29 primary testicular carcinoid cases from 7 academic institutions.
  • Two patients had carcinoid syndrome including diarrhea, hot flashes, and palpitations.
  • Nineteen were pure carcinoid tumors, 3 were associated with cystic teratoma, 2 with cysts lacking epithelial lining, 4 with epidermoid cyst, and 1 with dermoid cyst.
  • Mitotic figures were rare in primary carcinoid tumors with only 3 cases showing more than 2 per 10 HPF; necrosis was found in only 1 case.
  • Follow-up, available in 24 cases, ranged from 1 to 228 months (mean 52.7 mo); of the 20 patients with testicular typical carcinoid tumors found premortem, all were alive at last follow-up without recurrences or metastases.
  • Of the 4 patients with a primary atypical carcinoid tumor, 1 at the time of diagnosis had retroperitoneal and lung metastases who after chemotherapy underwent resection of the retroperitoneal tumor showing metastatic yolk sac tumor and embryonal carcinoma.
  • The other 2 patients with atypical carcinoid and follow-up had no evidence of disease at 68 and 114 months.
  • Most primary carcinoid tumors of the testis have a benign clinical course even if associated with epidermoid/dermoid cysts, or histologically mature teratoma.
  • However, lesions with the morphology of atypical carcinoid can occasionally exhibit metastatic spread.
  • [MeSH-major] Carcinoid Tumor / pathology. Testicular Neoplasms / pathology

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  • [ErratumIn] Am J Surg Pathol. 2010 Jul;34(7):1075. Ubright, Thomas M [corrected to Ulbright, Thomas M]
  • (PMID = 20351489.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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62. Chen KC, Chang YL, Pan CT, Lee YC: Esophageal atypical carcinoid tumor with tracheal invasion. J Thorac Cardiovasc Surg; 2007 Aug;134(2):524-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Esophageal atypical carcinoid tumor with tracheal invasion.
  • [MeSH-major] Carcinoid Tumor / pathology. Esophageal Neoplasms / pathology. Stents. Tracheal Neoplasms / pathology
  • [MeSH-minor] Administration, Oral. Aged. Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness. Palliative Care. Thalidomide / administration & dosage. Tomography, X-Ray Computed

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  • (PMID = 17662809.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4Z8R6ORS6L / Thalidomide
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