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Items 1 to 58 of about 58
1. Okano Y, Inayama M, Hatakeyama N, Hino H, Iwahara Y, Motoki T, Naruse K, Yokota Y, Ogushi F: Autopsy case of rapid progressive atypical carcinoid of the lung discovered with multiple nodular shadows. J Med Invest; 2008 Feb;55(1-2):142-6
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  • [Title] Autopsy case of rapid progressive atypical carcinoid of the lung discovered with multiple nodular shadows.
  • We report an autopsy case of rapid progressive atypical carcinoid of the lung discovered as multiple nodular shadows.
  • Both chest radiography and computed tomography revealed multiple nodules in both the lung and pleural effusion.
  • Samples from the wall-side pleural lesion were obtained by video-assisted thoracoscopic surgery under local anesthesia, and histological examination led to a diagnosis of atypical carcinoid.
  • The primary site was identified as the lung after autopsy.
  • We believe that early detection is crucial in the treatment of atypical carcinoid due to poor prognosis.
  • [MeSH-major] Carcinoid Tumor / pathology. Carcinoid Tumor / radiography. Lung / radiography. Lung Neoplasms / pathology. Lung Neoplasms / radiography

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  • (PMID = 18319557.001).
  • [ISSN] 1343-1420
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Isaka T, Maruno M, Suzuki T, Sato M, Yoshimine T: Skull metastases from atypical pulmonary carcinoid tumor in a 19-year-old man. Neurol Med Chir (Tokyo); 2006 Dec;46(12):609-13
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  • [Title] Skull metastases from atypical pulmonary carcinoid tumor in a 19-year-old man.
  • A 19-year-old man presented with a rare skull metastasis from atypical pulmonary carcinoid tumor (APCT) manifesting as headache, diplopia, and cough.
  • Head magnetic resonance imaging showed a skull base tumor extending from the posterior clinoid process to the clivus, and calvarial tumors in the right temporal and occipital bones.
  • Chest and abdominal computed tomography showed a round tumor, 4 cm in diameter, in the lower lobe of the right lung and multiple small tumors in the liver.
  • Surgery for the calvarial tumor in the right temporal bone was performed on June 27, 2003.
  • The histological diagnosis was skull metastasis of neuroendocrine tumor.
  • Partial resection of the right lower lobe was performed for the lung tumor on August 22, 2003.
  • The histological diagnosis was atypical carcinoid tumor.
  • The patient died of progression of the tumors in the lung and liver on April 19, 2004.
  • We must consider APCT in the differential diagnosis of pulmonary tumors in adolescents, and perform follow-up observation or treatment, including surgery, if APCT is suspected.
  • [MeSH-major] Carcinoid Tumor / secondary. Lung Neoplasms / pathology. Skull Neoplasms / secondary

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  • (PMID = 17185889.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Krüger S, Buck AK, Blumstein NM, Pauls S, Schelzig H, Kropf C, Schumann C, Mottaghy FM, Hombach V, Reske SN: Use of integrated FDG PET/CT imaging in pulmonary carcinoid tumours. J Intern Med; 2006 Dec;260(6):545-50
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  • [Title] Use of integrated FDG PET/CT imaging in pulmonary carcinoid tumours.
  • BACKGROUND: Integrated positron emission tomography (PET)/computed tomography (CT) scanners have been recently introduced in the diagnostic work-up of suspected pulmonary malignancy and demonstrate encouraging results in the staging of nonsmall-cell lung cancer.
  • OBJECTIVE: To evaluate the usefulness of integrated FDG PET/CT in pulmonary carcinoid tumours.
  • METHODS: We studied 13 patients (mean age +/- 1 SD, 57 +/- 11 years) with pulmonary carcinoid tumours.
  • Final histological diagnosis confirmed 12 typical and one atypical pulmonary carcinoid.
  • None of the patients had recurrent carcinoid disease or died during follow-up (864 +/- 218 days).
  • Mean standardized uptake value (SUV) of (18)F-fluorodeoxyglucose (FDG) in typical carcinoids was 3.0 +/- 1.5 (range 1.2 - 6.6); SUV in the atypical carcinoid was remarkably high with a value of 8.5.
  • FDG uptake in pulmonary carcinoid tumours is often lower than expected for malignant tumours.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Image Enhancement / methods. Lung Neoplasms / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Cell Division / physiology. Female. Fluorodeoxyglucose F18 / pharmacokinetics. Humans. Lung / radiography. Lung / radionuclide imaging. Male. Middle Aged. Radiopharmaceuticals / pharmacokinetics

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  • (PMID = 17116005.001).
  • [ISSN] 0954-6820
  • [Journal-full-title] Journal of internal medicine
  • [ISO-abbreviation] J. Intern. Med.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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4. Machado MC, Sá SV, Goldbaum TS, Catania M, Campos VC, Corrêa-Giannella ML, Giannella-Neto D, Salgado LR: In vivo response to growth hormone-releasing peptide-6 in adrenocorticotropin-dependent Cushing's syndrome by lung carcinoid tumor is associated with growth hormone secretagogue receptor type 1a mRNA expression. J Endocrinol Invest; 2007 Apr;30(4):334-40
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  • [Title] In vivo response to growth hormone-releasing peptide-6 in adrenocorticotropin-dependent Cushing's syndrome by lung carcinoid tumor is associated with growth hormone secretagogue receptor type 1a mRNA expression.
  • GH secretagogues (GHS) have been used for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS) since 1997 due to their ability to increase ACTH and cortisol levels in Cushing's disease.
  • The aim of this study was to correlate ACTH response to GH-releasing peptide-6 (GHRP-6) in vivo with GH secretagogue receptor type 1a (GHSR-1a) mRNA expression in a patient with lung carcinoid tumor.
  • The patient was a 26-yr-old male with diagnosis of ACTH-dependent CS.
  • Computed tomography (CT) and MRI of thorax/abdomen/cervical were negative and 111In-pentetreotide scintigraphy depicted abnormal uptake on the right lung.
  • The patient was submitted to right thoracotomy for exeresis of lung nodule and hilar lymph node which were characterized as atypical lung carcinoid tumor and he presented clinical and laboratorial remission after surgery.
  • GHSR-1a mRNA expression was studied with real-time quantitative PCR and tumor data were compared with fragments of normal lung and pituitary.
  • There was a higher GHSR-1a expression in the lung carcinoid tumor as compared with normal tissues.
  • The ACTH response to GHRP-6 in a patient with ectopic ACTH production by a lung carcinoid tumor was associated with GHSR-1a expression in the tumor tissue, suggesting an association between GHSR-1a mRNA overexpression and the in vivo response to GHS.
  • [MeSH-major] ACTH Syndrome, Ectopic / diagnosis. Carcinoid Tumor / diagnosis. Cushing Syndrome / diagnosis. Lung Neoplasms / diagnosis. Oligopeptides / pharmacology. Receptors, G-Protein-Coupled / genetics
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Techniques, Endocrine. Gene Expression Regulation, Neoplastic / drug effects. Humans. Male. RNA, Messenger / metabolism. Receptors, Ghrelin


5. Belak J, Kudlac M, Zak V, Cavarga I, Kocan P, Böör A, Stebnicky M, Somos A, Tkacova R: Surgical management of bronchopulmonary carcinoid tumors: experience over 8 years and review of the literature. Tumori; 2010 Jan-Feb;96(1):84-9
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  • [Title] Surgical management of bronchopulmonary carcinoid tumors: experience over 8 years and review of the literature.
  • Our purpose was to study the characteristics, surgical approaches and outcome in patients with primary bronchopulmonary carcinoid tumors.
  • METHODS: Between 2001 and 2007, bronchopulmonary carcinoid tumors were removed in 11 of a total of 287 patients who underwent surgery for primary lung malignancies in our tertiary referral center.
  • Histological findings revealed typical carcinoid in 10 patients and atypical carcinoid in one.
  • The surgical approach included 8 lung resections (6 lobectomies, 1 bilobectomy, 1 segmentectomy), and 3 bronchoplastic tumor removals.
  • In 2008, clinical examination and chest X-ray revealed no recurrence of the carcinoid and no long-term postoperative complications in any patient.
  • CONCLUSIONS: In the light of our study and the review of the literature we conclude that early recognition of primary bronchopulmonary carcinoid tumors followed by adequate surgical removal of the malignancy are essential for complete remission of the disease.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Lung Neoplasms / diagnosis. Lung Neoplasms / surgery

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  • (PMID = 20437863.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Italy
  • [Number-of-references] 29
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6. Tiktinsky E, Horne T, Agranovich S, Lantsberg S: Intramuscular metastasis of carcinoid tumor: a rare manifestation. Clin Nucl Med; 2008 Jul;33(7):484-5
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  • [Title] Intramuscular metastasis of carcinoid tumor: a rare manifestation.
  • A 43-year-old man presented with a 2-month history of left upper lobectomy due to an atypical lung carcinoid tumor.
  • The scans showed slightly increased diffused tracer uptake in the apex of the left lung, most probably due to postoperative changes.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Muscle Neoplasms / radionuclide imaging. Octreotide
  • [MeSH-minor] Adult. Humans. Lung / radionuclide imaging. Male. Neoplasm Metastasis. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 18580236.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] RWM8CCW8GP / Octreotide
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7. Hamad AM, Rizzardi G, Marulli G, Rea F: Nodal recurrence of pulmonary carcinoid 30 years after primary resection. J Thorac Oncol; 2008 Jun;3(6):680-1
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  • [Title] Nodal recurrence of pulmonary carcinoid 30 years after primary resection.
  • We present a case of nodal recurrence of carcinoid tumor in a 48-year-old male patient, 30 years after resection of primary tumor.
  • Octreoscan was used for diagnosis and localization of the mass.
  • Surgical resection was successful and histopathologic examination revealed lymph node infiltrated with atypical carcinoid.
  • [MeSH-major] Carcinoid Tumor / surgery. Lung Neoplasms / surgery. Neoplasm Recurrence, Local / diagnosis. Pneumonectomy / methods
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Positron-Emission Tomography. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18520814.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Vigg A, Mantri S, Swarnalata G, Mulay K: Atypical carcinoid tumour. Indian J Chest Dis Allied Sci; 2005 Jul-Sep;47(3):213-5
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  • [Title] Atypical carcinoid tumour.
  • Carcinoid tumour is a rare entity accounting for less than two percent of bronchial neoplasms.
  • More offten, it presents as a central endobronchial tumour.
  • The peripheral type of carcinoid tumour is relatively rare.
  • [MeSH-major] Carcinoid Tumor / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Female. Humans

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  • (PMID = 16022152.001).
  • [ISSN] 0377-9343
  • [Journal-full-title] The Indian journal of chest diseases & allied sciences
  • [ISO-abbreviation] Indian J Chest Dis Allied Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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9. McIntire M, Shah ND, Kim AW, Gattuso P, Liptay MJ: Cytologic imprints of giant atypical bronchopulmonary carcinoid tumor of the lung with extensive oncocytic component. Diagn Cytopathol; 2008 Dec;36(12):887-90
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  • [Title] Cytologic imprints of giant atypical bronchopulmonary carcinoid tumor of the lung with extensive oncocytic component.
  • Bronchopulmonary carcinoid tumors are found in less than 2 of 100,000 people yearly and comprise approximately 1-2% of all lung neoplasms.
  • Diagnosis is usually made by bronchoscopy with bronchial brushings or biopsy.
  • We present the cytologic imprint findings of a case of a 66-year-old man with an atypical giant bronchopulmonary carcinoid with extensive oncocytic component, who underwent a total right pneumonectomy.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Carcinoma, Neuroendocrine / pathology. Lung Neoplasms / diagnosis

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18855906.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Kiratli H, Yilmaz PT, Yildiz ZI: Metastatic atypical carcinoid tumor of the inferior rectus muscle. Ophthal Plast Reconstr Surg; 2008 Nov-Dec;24(6):482-4
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  • [Title] Metastatic atypical carcinoid tumor of the inferior rectus muscle.
  • A 74-year-old man who had been treated for pulmonary atypical carcinoid tumor 3 years earlier developed diplopia.
  • Incisional biopsy of the affected muscle revealed metastatic atypical carcinoid tumor infiltration that immunostained positively for epithelial membrane antigen, synaptophysin, and chromogranin.
  • Systemic chemotherapy consisting of cisplatin and etoposide was prescribed to address the orbital tumor and a contemporaneously discovered hepatic locus.
  • Although metastatic bronchogenic carcinoid tumor in the orbit, and in the inferior rectus muscle in particular, is highly unusual, this condition must be considered in the differential diagnosis of an isolated extraocular muscle enlargement in a patient with a history of systemic carcinoid tumor.
  • [MeSH-major] Carcinoid Tumor / secondary. Eye Neoplasms / secondary. Lung Neoplasms / pathology. Muscle Neoplasms / secondary. Oculomotor Muscles
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19033849.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Nannini N, Bertolini F, Cavazza A, Casali C, Mengoli MC, Rossi G: Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor. Endocr Pathol; 2010 Jun;21(2):120-4
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  • [Title] Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor.
  • Carcinoid tumors of the lung may show several growth patterns and cell types.
  • We report here a previously undescribed case of primary pulmonary atypical carcinoid with prominent mucinous stroma, an exceedingly rare variant of carcinoid tumor so far reported only in the thymus.
  • The tumor was discovered in a 50-year-old, non-smoker woman, and pursued an aggressive behavior.
  • The lack of TTF-1 expression and the positive staining with hormonal receptors made the diagnosis very challenging.
  • Differential diagnosis with other primary and metastatic mucin-rich tumors is also discussed.
  • [MeSH-major] Carcinoid Tumor / pathology. Carcinoma, Neuroendocrine / pathology. Lung Neoplasms / pathology. Mucus / metabolism
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Pneumonectomy


12. Olgac G, Peirovi F, Yilmaz A, Kutlu CA: Giant carcinoid tumor mimicking pulmonary sequestration. Ann Thorac Surg; 2007 Oct;84(4):1375-6
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  • [Title] Giant carcinoid tumor mimicking pulmonary sequestration.
  • A 42-year-old woman who previously underwent two consecutive thoracotomies for a lower lobe mass in her right lung was referred to our clinic for further management.
  • Then a right lower lobectomy was undertaken through a hemi-clamshell incision, and histopathology revealed an atypical carcinoid tumor.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchopulmonary Sequestration / diagnosis. Carcinoid Tumor / diagnosis
  • [MeSH-minor] Adult. Biopsy, Needle. Bronchoscopy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Pneumonectomy / methods. Reoperation. Risk Assessment. Severity of Illness Index. Treatment Outcome

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  • (PMID = 17889003.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Bode-Lesniewska B, Hodler J, von Hochstetter A, Guillou L, Exner U, Caduff R: Late solitary bone metastasis of a primary pulmonary synovial sarcoma with SYT-SSX1 translocation type: case report with a long follow-up. Virchows Arch; 2005 Mar;446(3):310-5
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  • One of the rarest primary locations is the lung.
  • We describe a 73-year-old female patient who presented with a solitary malignant bone tumor 8 years after the resection of a lung neoplasm.
  • The bone tumor was classified as an osteosarcoma and the lung tumor as an atypical carcinoid tumor at their first respective diagnostic work-ups.
  • Reevaluation of the tumor samples at the time of the local recurrence of the bone tumor 6 years following the initial symptoms of the bone tumor lead to the reclassification of both specimens as synovial sarcomas.
  • The patient died 14 years after the resection of the primary synovial sarcoma of the lung and 6 years following the occurrence of the bone metastasis.
  • [MeSH-major] Bone Neoplasms / secondary. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Sarcoma, Synovial / genetics. Sarcoma, Synovial / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Oncogene Proteins, Fusion. Osteosarcoma / pathology. Reverse Transcriptase Polymerase Chain Reaction. Time Factors. Translocation, Genetic

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  • (PMID = 15668803.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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14. Ito T, Kim K, Taira M, Kinoshita M, Ikeda N: [Atypical carcinoid of the lung with abnormal elevation of serum ProGRP level; report of a case]. Kyobu Geka; 2010 Jun;63(6):505-7
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  • [Title] [Atypical carcinoid of the lung with abnormal elevation of serum ProGRP level; report of a case].
  • We report a rare case of an atypical carcinoid of the lung with the elevation of serum ProGRP.
  • Pulmonary carcinoid was pathologically suggested by a transbronchial lung biopsy.
  • Pathological diagnosis was atypical carcinoid.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis. Peptide Fragments / blood

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  • (PMID = 20533746.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptide Fragments; 0 / Recombinant Proteins; 0 / pro-gastrin-releasing peptide (31-98)
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15. Pelosi G, Rodriguez J, Viale G, Rosai J: Typical and atypical pulmonary carcinoid tumor overdiagnosed as small-cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients. Am J Surg Pathol; 2005 Feb;29(2):179-87
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  • [Title] Typical and atypical pulmonary carcinoid tumor overdiagnosed as small-cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients.
  • Seven patients with typical or atypical pulmonary carcinoid tumors overdiagnosed as small-cell carcinoma on bronchoscopic biopsies are described.
  • Bronchial biopsies from 9 consecutive small-cell lung carcinoma patients were used as control group for histologic and immunohistochemical studies (cytokeratins, chromogranin A, synaptophysin, Ki-67 [MIB-1], and TTF-1).
  • The carcinoid tumors presented as either central or peripheral lesions composed of tumor cells with granular, sometimes coarse chromatin pattern, high levels of chromogranin A/synaptophysin immunoreactivity, and low (<20%) Ki-67 (MIB-1) labeling index.
  • The tumor stroma contained thin-walled blood vessels.
  • Small-cell carcinomas always showed central tumor location, finely dispersed nuclear chromatin, lower levels of chromogranin A/synaptophysin, and high (>50%) Ki-67 (MIB-1) labeling index.
  • Judging from this study, overdiagnosis of carcinoid tumor as small-cell carcinoma in small crushed bronchial biopsies remains a significant potential problem in a worldwide sample of hospital settings.
  • Careful evaluation of hematoxylin and eosin sections remains the most important tool for the differential diagnosis, with evaluation of tumor cell proliferation by Ki-67 (MIB-1) labeling index emerging from our review as the most useful ancillary technique for the distinction.
  • [MeSH-major] Carcinoid Tumor / pathology. Carcinoma, Small Cell / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged


16. Detterbeck FC: Management of carcinoid tumors. Ann Thorac Surg; 2010 Mar;89(3):998-1005
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  • [Title] Management of carcinoid tumors.
  • Primary bronchopulmonary carcinoids comprise a significant proportion of carcinoid tumors.
  • The clinical presentation allows prediction of the diagnosis and cell type and directs evaluation and treatment.
  • Young age, central tumor, and no nodal enlargement are highly suggestive of typical carcinoid.
  • All bronchopulmonary carcinoids are malignant (though indolent), and surgical intervention is the mainstay of treatment.
  • Mediastinoscopy is suggested when there is moderate suspicion of atypical carcinoid (central cN1 or peripheral cN0), with lobectomy and lymphadenectomy if the mediastinal nodes are benign.
  • For a high suspicion of atypical carcinoid (central cN2, peripheral cN1, 2), imaging for distant metastases and mediastinoscopy is suggested, with multimodality treatment for an atypical carcinoid with N2 involvement.
  • [MeSH-major] Bronchial Neoplasms. Carcinoid Tumor. Lung Neoplasms

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172187.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 67
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17. Davini F, Gonfiotti A, Comin C, Caldarella A, Mannini F, Janni A: Typical and atypical carcinoid tumours: 20-year experience with 89 patients. J Cardiovasc Surg (Torino); 2009 Dec;50(6):807-11
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  • [Title] Typical and atypical carcinoid tumours: 20-year experience with 89 patients.
  • AIM: The aim of this study was to conduct a retrospective clinical and pathological analysis of the authors' 20-year experience on treatment of typical and atypical carcinoid tumours.
  • METHODS: A retrospective clinical and pathological analysis was conducted on 89 patients treated for bronchial carcinoid neoplasms at the Division of Thoracic Surgery, Hospital of Florence (Italy) between January 1986 and January 2006.
  • Diagnosis was made with radiological methods such as plain chest roentgenography, computed tomography (CT), and bronchoscopy.
  • In 38 cases of central lesion the diagnosis was obtained by endobronchial biopsy.
  • A correct pathological diagnosis was obtained before surgery in 58 patients; in the others resected cases the correct diagnosis was determined by intraoperative histology during surgery.
  • RESULTS: There were 63 (70.8%) typical carcinoid (TC) and 26 (29,2%) atypical carcinoid (AC).
  • On the basis of the hystopatological documentation of all patients operated before 1999 (60 patients) the authors observed that in 4 cases (6.6%) the diagnosis has changed from AC to TC while only 1 case (1.6%) of AC was classified as TC with new criterias.
  • CONCLUSIONS: Anatomical resection, including formal lobectomy (or pneumonectomy when indicated) and radical mediastinal lymphadenectomy, should be performed in carcinoid tumours.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis. Pneumonectomy / methods
  • [MeSH-minor] Adult. Aged. Biopsy. Bronchoscopy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lymph Node Excision / methods. Male. Mediastinum. Middle Aged. Retrospective Studies. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19935614.001).
  • [ISSN] 0021-9509
  • [Journal-full-title] The Journal of cardiovascular surgery
  • [ISO-abbreviation] J Cardiovasc Surg (Torino)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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18. Endo T, Hasegawa T, Tezuka Y, Kanai Y, Otani S, Yamamoto S, Tetsuka K, Sato Y, Endo S, Sohara Y: [Atypical pulmonary carcinoid tumor with abnormal elevation of serum gastrin-releasing peptide precursor: report of a case]. Kyobu Geka; 2008 Oct;61(11):993-5
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  • [Title] [Atypical pulmonary carcinoid tumor with abnormal elevation of serum gastrin-releasing peptide precursor: report of a case].
  • We report a rare case of atypical pulmonary carcinoid tumor accompanied by elevation of serum gastrin-releasing peptide precursor (ProGRP).
  • Chest computed tomography (CT) revealed a solitary pulmonary tumor in the left lower lobe with sub-carinal lymph node enlargement.
  • Transbronchial lung biopsy showed a pulmonary carcinoid, therefore left lower lobectomy with mediastinal lymph node dissection was performed.
  • Histopathological diagnosis showed an atypical pulmonary carcinoid tumor.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis. Peptide Fragments / blood

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  • (PMID = 18939440.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptide Fragments; 0 / Recombinant Proteins; 0 / pro-gastrin-releasing peptide (31-98)
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19. Vidal A, Lorenzo MJ, Isidro ML, Cordido F: Atypical thymic carcinoid in multiple endocrine neoplasia type 1 syndrome. J Endocrinol Invest; 2007 Jul-Aug;30(7):601-2
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  • [Title] Atypical thymic carcinoid in multiple endocrine neoplasia type 1 syndrome.
  • An asymptomatic, non-smoker patient carrier of a multiple endocrine neoplasia syndrome type 1 (MEN1) mutation was diagnosed with invasive atypical thymic carcinoid tumor.
  • After surgical treatment the tumor reappeared albeit without metastasis.
  • Thymic carcinoid is a well-known cause of mortality in MEN1, and usually metastatic disease is present at diagnosis.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Multiple Endocrine Neoplasia Type 1 / complications. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Adult. Humans. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Male. Pericardium / pathology


20. Stević R, Jovanović D, Masulović D, Pesut D, Vasić N, Stojić J: [Clinico-radiological characteristics of bronchial carcinoid]. Acta Chir Iugosl; 2009;56(4):51-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinico-radiological characteristics of bronchial carcinoid].
  • OBJECTIVES: To review clinical and radiological characteristics of a patients with bronchial carcinoid.
  • METHODS: In this retrospective study, we reviewed the clinical, pathological and imaging findings in 42 patients diagnosed with bronchial carcinoid during the seven years period.
  • Thirty patients had typical and 12 atypical bronchial carcinoid.
  • Tumor was localized in 28 patients in the left, and 14 in the right lung.
  • On radiographs carcinoid manifested as tumor shadow in 40.5%, nodule and atelectasis in 21.4% cases each respectively, pleural effusion and pneumonia in 7.1% each respectively and hyperinflation in 2.4% of the cases.
  • Computerized tomography revealed endoluminal tumor in 30.9% patients.
  • CONCLUSION: Major imaging findings are central, tumor mass or nodule and obstruction signs like atelectasis.
  • Diagnosis is confirmed by pathological examination of samples taken by bronchoscopy or surgery.
  • [MeSH-major] Bronchial Neoplasms / radiography. Carcinoid Tumor / radiography

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  • (PMID = 20419997.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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21. Divisi D, Crisci R: Carcinoid tumors of the lung and multimodal therapy. Thorac Cardiovasc Surg; 2005 Jun;53(3):168-72
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  • [Title] Carcinoid tumors of the lung and multimodal therapy.
  • Diagnosis was obtained in 28 patients with fibre-optic bronchoscopy and in 14 patients with CT-guided trans-thoracic needle biopsy.
  • RESULTS: There were 26 typical and 16 atypical carcinoids.
  • The 3-year and the 5-year survival rates in the typical and atypical carcinoid groups were 100 % and 96 % vs. 81 % and 68 %, respectively (p < 0.001).
  • [MeSH-major] Carcinoid Tumor / surgery. Lung Neoplasms / surgery. Pneumonectomy

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  • (PMID = 15926097.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Chromogranin A; 0 / Chromogranins; 0 / Synaptophysin; RWM8CCW8GP / Octreotide
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22. Naccini B, Fitting JW, Letovanec I: [Current approach to bronchial carcinoid tumors]. Rev Med Suisse; 2007 Nov 21;3(134):2655-6, 2658-60, 2662
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  • [Title] [Current approach to bronchial carcinoid tumors].
  • Neuroendocrine tumors of the lung comprise typical and atypical carcinoids, as well as large cell neuroendocrine carcinomas and small cell carcinomas.
  • However carcinoid tumours differ from the latter two by their clinical presentation, radiographic, histological appearances, and treatment modalities as well as prognosis.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Carcinoid Tumor / therapy. Lung Neoplasms / diagnosis. Lung Neoplasms / therapy

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  • (PMID = 18159699.001).
  • [ISSN] 1660-9379
  • [Journal-full-title] Revue médicale suisse
  • [ISO-abbreviation] Rev Med Suisse
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 31
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23. de Matos LL, Trufelli DC, das Neves-Pereira JC, Danel C, Riquet M: Cushing's syndrome secondary to bronchopulmonary carcinoid tumor: report of two cases and literature review. Lung Cancer; 2006 Sep;53(3):381-6
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  • [Title] Cushing's syndrome secondary to bronchopulmonary carcinoid tumor: report of two cases and literature review.
  • Bronchopulmonary carcinoid tumors have been associated with a variety of endocrine disorders including Cushing's syndrome (CS), which is caused by ectopic adrenocorticotrophic hormone (ACTH) secretion.
  • We report two cases of CS secondary to bronchopulmonary carcinoid tumors.
  • Chest computed tomography and Octreoscan showed a peripheral nodule in the left-superior lobe of the lung.
  • After lobectomy, a typical bronchopulmonary carcinoid was diagnosed.
  • After lobectomy, an atypical bronchopulmonary carcinoid was diagnosed.
  • Neither of these patients had hypophysary microadenomas, adrenal adenomas or recurrence of CS after surgical treatment, demonstrating that CS was caused solely by the presence of the bronchopulmonary carcinoid tumors.
  • [MeSH-major] Bronchial Neoplasms / complications. Bronchial Neoplasms / diagnosis. Carcinoid Tumor / complications. Carcinoid Tumor / diagnosis. Cushing Syndrome / complications. Cushing Syndrome / diagnosis. Lung Neoplasms / complications. Lung Neoplasms / diagnosis


24. Otake Y, Aoki M, Nakanishi T, Hashimoto K: Atypical carcinoid of thymus associated with multiple endocrine neoplasia syndrome type 1. Gen Thorac Cardiovasc Surg; 2010 Oct;58(10):534-7
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  • [Title] Atypical carcinoid of thymus associated with multiple endocrine neoplasia syndrome type 1.
  • Thymic carcinoid associated with multiple endocrine neoplasia syndrome type 1 (MEN-1) is a rare tumor.
  • We report a case of MEN-1-related thymic carcinoid.
  • She underwent thymectomy with partial resection of the left innominate vein and lung.
  • Histological examination revealed atypical carcinoid with infiltration.
  • MEN-1-related thymic carcinoid is often insidious with a poor prognosis.
  • We suggest chest computed tomography scan or magnetic resonance imaging for MEN-1 patients and serological or genetic screening for patients with thymic carcinoid to screen for MEN-1.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Multiple Endocrine Neoplasia Type 1 / diagnosis. Thymus Neoplasms / diagnosis


25. Mendes S, Gallego J, Caldeira J, Palhano M, Cruz J, Cravino J: [Pulmonary carcinoid tumors--ten years experience]. Rev Port Cir Cardiotorac Vasc; 2005 Jan-Mar;12(1):21-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pulmonary carcinoid tumors--ten years experience].
  • Pulmonary carcinoid tumors are rare, accounting for as many as 2% of all pulmonary neoplasms and for 10% of carcinoid tumors overall.
  • They have a subclassification into typical classed as low-grade malignant neoplasm and atypical more aggressive, with more potential to cause local invasion.
  • In this paper, the authors report a retrospective study of 25 patients, who had the diagnosis of pulmonary carcinoid tumors and had been operated between January of 1994 and August of 2004.
  • We conclude that this tumors must be considered malignant in the surgical approach.
  • [MeSH-major] Carcinoid Tumor / surgery. Lung Neoplasms / surgery

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  • (PMID = 15895123.001).
  • [ISSN] 0873-7215
  • [Journal-full-title] Revista portuguesa de cirurgia cardio-torácica e vascular : órgão oficial da Sociedade Portuguesa de Cirurgia Cardio-Torácica e Vascular
  • [ISO-abbreviation] Rev Port Cir Cardiotorac Vasc
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Portugal
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26. Stoll LM, Johnson MW, Burroughs F, Li QK: Cytologic diagnosis and differential diagnosis of lung carcinoid tumors a retrospective study of 63 Cases with histologic correlation. Cancer Cytopathol; 2010 Dec 25;118(6):457-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic diagnosis and differential diagnosis of lung carcinoid tumors a retrospective study of 63 Cases with histologic correlation.
  • BACKGROUND: Neuroendocrine (NE) neoplasms of the lung are a spectrum of tumors including typicalcarcinoid (TC), atypical carcinoid tumor (ACT), small cell lung carcinoma (SCLC), and large cell NEcarcinoma (LCNEC).
  • The cytology specimens were comprised of 49 cases of lung fine-needle aspiriation specimens and 14 cases of lung brushings/washings.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / pathology. Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 21243734.001).
  • [ISSN] 1934-662X
  • [Journal-full-title] Cancer cytopathology
  • [ISO-abbreviation] Cancer Cytopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Gupta R, Dastane A, McKenna RJ Jr, Marchevsky AM: What can we learn from the errors in the frozen section diagnosis of pulmonary carcinoid tumors? An evidence-based approach. Hum Pathol; 2009 Jan;40(1):1-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What can we learn from the errors in the frozen section diagnosis of pulmonary carcinoid tumors? An evidence-based approach.
  • The intraoperative diagnosis of pulmonary neuroendocrine tumors can be difficult.
  • Frozen section diagnosis was requested on 87 neuroendocrine tumors including 58 typical carcinoids, 8 atypical carcinoids, 18 large cell neuroendocrine carcinomas, and 3 small cell carcinomas from 2405 patients that underwent frozen section diagnosis at Cedars-Sinai Medical Center from 2002 to 2007.
  • The deferral and error rate for carcinoid tumors was 4.13% and 7.5%, respectively, and resulted in 4 unnecessary lobectomies and 2 second thoracotomies.
  • Thirty one pathologic features were evaluated in the 66 carcinoid tumors and 10 frozen sections each of lymphoma, squamous cell carcinoma, and metastatic breast carcinoma.
  • Positive likelihood ratios identified 11 pathologic features that were useful for the diagnosis of carcinoid tumor from other neoplasms.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Diagnostic Errors. Evidence-Based Medicine. Frozen Sections. Lung Neoplasms / diagnosis
  • [MeSH-minor] Bayes Theorem. Diagnosis, Differential. Humans. Predictive Value of Tests

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  • (PMID = 18973920.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Bini A, Brandolini J, Cassanelli N, Davoli F, Dolci G, Sellitri F, Stella F: Typical and atypical pulmonary carcinoids: our institutional experience. Interact Cardiovasc Thorac Surg; 2008 May;7(3):415-8
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  • [Title] Typical and atypical pulmonary carcinoids: our institutional experience.
  • Pulmonary carcinoids are rare malignant neoplasms, accounting for 2-5% of all lung tumors, with an approximate annual incidence of 2.3-2.8 cases per million of the population.
  • All the patients underwent preoperative fibrobronchoscopy: preoperative diagnosis was made in 28 patients (52%).
  • Surgical treatment consisted of: 31 standard lobectomies, 6 pneumonectomies, 5 bilobectomies, 2 sleeve lobectomies, 2 anatomic segmentectomies, 6 wedge resections; two patients were managed with sleeve bronchial procedure of the left main bronchus without lung resection.
  • Overall, 5-year survival was 91%, 10 years 83%: 5-year survival was 91% for typical carcoinoids (TC) vs. 88% for atypical (AC), 10 years 91% for TC and 44% for AC (significant value, P=0.0487).
  • Carcinoid tumors are a distinct group of neuroendocrine tumors with a good prognosis in most cases.
  • [MeSH-major] Bronchial Neoplasms. Carcinoid Tumor

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  • (PMID = 18349148.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Capovilla M, Kambouchner M, Bernier M, Soulier A, Tissier F, Saintigny P: Late cerebellar relapse of a juvenile bronchial carcinoid. Clin Lung Cancer; 2007 Mar;8(5):339-41
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  • [Title] Late cerebellar relapse of a juvenile bronchial carcinoid.
  • The most frequent histologic subtype is well differentiated neuroendocrine tumor, or carcinoid.
  • They have a variable biologic behavior, ranging from benign to malignant tumors capable of very late recurrence or metastasis.
  • Liver and lung are frequent sites of carcinoid metastasis, and the central nervous system is exceptionally involved.
  • We report the case of a child with a pulmonary carcinoid initially considered typical, who presented with relapse in the cerebellum and mediastinum 16 years later.
  • After review of the pathology slides, primary and metastatic tumors were reclassified as atypical carcinoid according to the criteria of the 2004 World Health Organization classification of lung tumors.
  • This unusual case emphasizes the value of reviewing pulmonary carcinoids diagnosed before 1998 in order to distinguish typical from atypical lesions and to define follow-up modalities more clearly.
  • [MeSH-major] Bronchial Neoplasms / pathology. Carcinoid Tumor / pathology. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / secondary

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  • (PMID = 17562235.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Daniels CE, Lowe VJ, Aubry MC, Allen MS, Jett JR: The utility of fluorodeoxyglucose positron emission tomography in the evaluation of carcinoid tumors presenting as pulmonary nodules. Chest; 2007 Jan;131(1):255-60
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  • [Title] The utility of fluorodeoxyglucose positron emission tomography in the evaluation of carcinoid tumors presenting as pulmonary nodules.
  • BACKGROUND: Fluorodeoxyglucose positron emission tomography (FDG-PET) is sensitive for detection of neoplastic solitary pulmonary nodules but may have decreased sensitivity for detection of carcinoid tumors.
  • Our purpose was to determine the sensitivity of FDG-PET to detect pulmonary carcinoid tumors.
  • METHODS: We performed a retrospective review of our institutional results regarding FDG-PET in the setting of thoracic carcinoid neoplasms.
  • We identified 16 patients with a pathologic diagnosis of bronchial carcinoid who had an antecedent FDG-PET (from 2000 to 2004).
  • RESULTS: Sixteen patients had a diagnosis of carcinoid tumor, typical in 11 patients and atypical in 5 patients.
  • CONCLUSIONS: FDG-PET imaging is useful for evaluation of typical and atypical thoracic carcinoid tumors.
  • Although overall PET sensitivity for detection of carcinoid tumors is somewhat reduced as compared to non-small cell lung cancer, it is much higher than prior reports suggest.
  • [MeSH-major] Carcinoid Tumor / radionuclide imaging. Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Fluorodeoxyglucose F18. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Solitary Pulmonary Nodule / radionuclide imaging

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  • (PMID = 17218584.001).
  • [ISSN] 0012-3692
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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31. Nogales FF, Buriticá C, Regauer S, González T: Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors. Am J Surg Pathol; 2005 Sep;29(9):1247-51
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  • [Title] Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors.
  • We present, for the first time, two yolk sac tumors (YST) in women 37 and 18 years of age, one with a typical parietovisceral pattern and the other with a glandular pattern, which were associated with extensive areas of mucinous carcinoid (MC).
  • The tumor in the first case had numerous nodules of tubulopapillary YST that merged with well-differentiated MC.
  • The tumor in the second case consisted of an AFP-positive glandular YST, with a glandulopapillary pattern closely resembling fetal lung type adenocarcinoma, coexisting with an AFP-negative, cytokeratin 20-positive, atypical MC; transitional areas between the two components were also seen.
  • In the material from the recurrences and metastases; however, no YST was present, the atypical MC having become the predominant component including areas that had become carcinomatous.
  • The patient died 1 year after diagnosis.
  • It is important to differentiate the yolk sac and carcinoid components due to their different responses to chemotherapy and to evaluate the possibility of mucinous carcinoid developing into a highly aggressive carcinoma.
  • [MeSH-major] Carcinoid Tumor / pathology. Endodermal Sinus Tumor / pathology. Ovarian Neoplasms / drug therapy

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  • (PMID = 16096416.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / alpha-Fetoproteins
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32. Vazquez MF, Koizumi JH, Henschke CI, Yankelevitz DF: Reliability of cytologic diagnosis of early lung cancer. Cancer; 2007 Aug 25;111(4):252-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reliability of cytologic diagnosis of early lung cancer.
  • BACKGROUND: Baseline screening for lung cancer of 2968 high-risk men and women utilizing HRCT enrolled in ELCAP (Early Lung Cancer Action Project) was performed between 1993-2002.
  • Among them, 65 people had surgical resection of their screen-diagnosed lung cancer, 53 of them on the basis of a diagnosis of malignancy or atypical bronchioloalveolar proliferation (ABP) on fine needle aspiration (FNA) biopsy at Weill Medical College of Cornell University (WMC) prior to surgery.
  • The authors compared the diagnosis obtained from the FNA with the subsequent diagnosis from the surgical specimen to assess the reliability of a cytologic diagnosis of lung cancer on FNA of these screen-diagnosed lung cancers.
  • ), with preliminary on-site as well as final diagnosis rendered by a cytologist (M.V., J.K.).
  • These results were correlated with histologic diagnoses obtained as a result of consensus diagnosis by a panel of 5 expert pulmonary pathologists.
  • RESULTS: Of the 53 cases of lung cancer resected following FNA, 4 were diagnosed as atypical bronchioloalveolar proliferation (ABP), 14 as adenocarcinoma with bronchioloalveolar features (ADC-BAC), 28 as adenocarcinoma, not otherwise specified (ADC-NOS), 1 as squamous cell carcinoma (SQCC), 4 as nonsmall-cell carcinoma (NSCC), and 2 as typical carcinoid.
  • In the 49 cases with a malignant cytology and 4 cases of ABP, lung cancer was confirmed histologically.
  • The tumor sizes ranged from 4 mm to 40 mm, mean size 13mm.
  • The final expert panel histologic diagnosis was adenocarcinoma in 47 cases; of these, 42 were invasive (mixed subtype or acinar subtype), and 5 were a noninvasive (bronchioloalveolar carcinoma, BAC).
  • Three of the 42 invasive adenocarcinoma that had a predominant BAC component and 1 case of BAC were diagnosed as ABP on FNA; all were sampled at the periphery of the tumor.
  • Two cases of typical carcinoid on histology were also diagnosed as typical carcinoid on FNA.
  • CONCLUSIONS: Preoperative diagnosis of lung cancer detected by screening with HRCT could be reliably made by FNA.
  • A diagnosis of ABP on FNA may be indicative of noninvasive BAC or an invasive adenocarcinoma with prominent BAC features, usually sampled at its periphery.
  • [MeSH-major] Biopsy, Fine-Needle. Cytodiagnosis / methods. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Carcinoid Tumor / diagnosis. Carcinoma, Non-Small-Cell Lung / diagnosis. Humans. Neoplasms, Squamous Cell / diagnosis. Reproducibility of Results

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  • [CommentIn] Cancer. 2008 May 15;112(10):2329-30 [18407546.001]
  • (PMID = 17614298.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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33. Machuca TN, Cardoso PF, Camargo SM, Signori L, Andrade CF, Moreira AL, Moreira Jda S, Felicetti JC, Camargo JJ: Surgical treatment of bronchial carcinoid tumors: a single-center experience. Lung Cancer; 2010 Nov;70(2):158-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of bronchial carcinoid tumors: a single-center experience.
  • BACKGROUND: Bronchial carcinoid is an infrequent neoplasm with a neuroendocrine differentiation.
  • Surgical treatment is the gold standard therapy, with procedures varying from sublobar resections to complex lung sparing broncoplastic procedures.
  • PATIENTS AND METHODS: Retrospective review of 126 consecutive patients who underwent surgical treatment for bronchial carcinoid tumors between December 1974 and July 2007.
  • Preoperative bronchoscopic diagnosis was obtained in 74 cases (58.7%).
  • The procedures performed were: 19 sublobar resections (14,9%), 58 lobectomies (46%), 8 bilobectomies (6.3%), 6 pneumonectomies (4.7%), 2 sleeve segmentectomies (1.5%), 26 sleeve lobectomies (20.6%) and 9 bronchoplastic procedures without lung resection (7.1%).
  • Five and 10-year survival for typical and atypical carcinoids were 91, 89% and 56, 47%, respectively.
  • Overall disease-free survival at 5 years was 91.9% Statistical analysis showed that overall disease-free survival correlated with histology--typical vs. atypical--(p = 0.04) and stage (p = 0.02).
  • CONCLUSION: Surgery provides safe and adequate treatment to bronchial carcinoid tumors.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / surgery. Bronchoscopy. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery

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  • [Copyright] Copyright © 2010. Published by Elsevier Ireland Ltd.
  • (PMID = 20223552.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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34. Thomas R, Christopher DJ, Balamugesh T, Shah A: Clinico-pathologic study of pulmonary carcinoid tumours--a retrospective analysis and review of literature. Respir Med; 2008 Nov;102(11):1611-4
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  • [Title] Clinico-pathologic study of pulmonary carcinoid tumours--a retrospective analysis and review of literature.
  • OBJECTIVE: To determine the characteristic clinico-pathologic features of pulmonary carcinoid tumours in India.
  • METHODS: Retrospective analysis of the clinico-pathologic and radiologic data of patients with pulmonary carcinoid tumours from the department of Pulmonary Medicine of the Christian Medical College, a tertiary care teaching hospital in Southern India, over a study period of 3 years (2001-2004).
  • RESULTS: There were 25 cases of pulmonary carcinoid tumours: typical 22 (88%) and atypical 3 (12%).
  • There were 3 smokers (all of whom were males) in the typical carcinoid group and none in the atypical carcinoid group.
  • Carcinoid syndrome was not present in any patient.
  • Diagnosis was made by flexible bronchoscopy and bronchial biopsy in 23 patients (92%).
  • The tumour bled significantly following biopsy in most patients; however, there was no mortality, and only 1 patient required blood transfusion.
  • CONCLUSION: The clinico-pathologic and radiologic features of pulmonary carcinoid tumours are presented.
  • We report the first series of pulmonary carcinoid tumours from India.
  • [MeSH-major] Carcinoid Tumor / pathology. Lung Neoplasms / pathology

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  • (PMID = 18614346.001).
  • [ISSN] 1532-3064
  • [Journal-full-title] Respiratory medicine
  • [ISO-abbreviation] Respir Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 19
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35. Jang BG, Kim SY, Park SH: Multiple pulmonary atypical carcinoids presenting with long-standing Cushing syndrome masked by pulmonary tuberculosis. Pathol Int; 2009 Jun;59(6):399-404
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  • [Title] Multiple pulmonary atypical carcinoids presenting with long-standing Cushing syndrome masked by pulmonary tuberculosis.
  • This CS was due to the ectopic ACTH produced by the pulmonary atypical carcinoids, which were recognized at the disseminated stage 5 years after the initial presentation of CS.
  • Microscopically, multiple whitish nodules (up to 1.0 cm in diameter) of the wedge-resected lung were composed of small round cells appearing to be typical neuroendocrine but were diagnosed as atypical carcinoid, based on the findings of focal necrosis, high mitotic rates and multiple endolymphatic tumor emboli.
  • Immunohistochemically, tumor cells robustly stained for ACTH.
  • The delay of diagnosis is, in part, attributable to the pulmonary tuberculosis (one of the complications of hypercortisolism), because the pulmonary tuberculosis presented in the form of multiple nodules throughout the lung.
  • [MeSH-major] Carcinoid Tumor / complications. Cushing Syndrome / etiology. Lung Neoplasms / complications. Tuberculosis, Pulmonary / complications


36. Farhat CA, Parra ER, Rogers AV, Elian SN, Sheppard MN, Capelozzi VL: Using electron microscopy and multivariate cluster analysis to determine diagnosis and prognosis in cases of neuroendocrine lung carcinoma. J Bras Pneumol; 2008 Oct;34(10):804-11
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  • [Title] Using electron microscopy and multivariate cluster analysis to determine diagnosis and prognosis in cases of neuroendocrine lung carcinoma.
  • OBJECTIVE: To establish reproducible electron microscopic criteria for identifying the four major types of neuroendocrine tumors of the lung: carcinoid; atypical carcinoid; large cell neuroendocrine carcinoma; and small cell carcinoma.
  • Sixteen morphometric variables related to tumor cell differentiation were assessed in 27 tumors.
  • The tumors fell into three well-defined clusters, which represent the spectrum of neuroendocrine differentiation: typical carcinoid (cluster 1); atypical carcinoid and large cell neuroendocrine carcinoma (cluster 2); and small cell carcinoma (cluster 3).
  • Cluster 2 represents an intermediate step in neuroendocrine carcinogenesis, between typical carcinoid tumors and small cell carcinomas.
  • CONCLUSIONS: Our findings confirm that electron microscopy is useful in making the diagnosis and prognosis in cases of lung tumor.
  • [MeSH-major] Carcinoid Tumor / ultrastructure. Carcinoma, Large Cell / ultrastructure. Carcinoma, Neuroendocrine / ultrastructure. Lung Neoplasms / ultrastructure. Small Cell Lung Carcinoma / ultrastructure
  • [MeSH-minor] Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / ultrastructure. Cluster Analysis. Diagnosis, Differential. Humans. Kaplan-Meier Estimate. Microscopy, Electron. Prognosis. Retrospective Studies

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  • (PMID = 19009213.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
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37. Wang WP, Guo C, Berney DM, Ulbright TM, Hansel DE, Shen R, Ali T, Epstein JI: Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2010 Apr;34(4):519-24
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  • [Title] Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases.
  • Testicular carcinoid tumors are rare with only limited studies.
  • We identified 29 primary testicular carcinoid cases from 7 academic institutions.
  • Two patients had carcinoid syndrome including diarrhea, hot flashes, and palpitations.
  • Nineteen were pure carcinoid tumors, 3 were associated with cystic teratoma, 2 with cysts lacking epithelial lining, 4 with epidermoid cyst, and 1 with dermoid cyst.
  • Mitotic figures were rare in primary carcinoid tumors with only 3 cases showing more than 2 per 10 HPF; necrosis was found in only 1 case.
  • Follow-up, available in 24 cases, ranged from 1 to 228 months (mean 52.7 mo); of the 20 patients with testicular typical carcinoid tumors found premortem, all were alive at last follow-up without recurrences or metastases.
  • Of the 4 patients with a primary atypical carcinoid tumor, 1 at the time of diagnosis had retroperitoneal and lung metastases who after chemotherapy underwent resection of the retroperitoneal tumor showing metastatic yolk sac tumor and embryonal carcinoma.
  • The other 2 patients with atypical carcinoid and follow-up had no evidence of disease at 68 and 114 months.
  • Most primary carcinoid tumors of the testis have a benign clinical course even if associated with epidermoid/dermoid cysts, or histologically mature teratoma.
  • However, lesions with the morphology of atypical carcinoid can occasionally exhibit metastatic spread.
  • [MeSH-major] Carcinoid Tumor / pathology. Testicular Neoplasms / pathology

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  • [ErratumIn] Am J Surg Pathol. 2010 Jul;34(7):1075. Ubright, Thomas M [corrected to Ulbright, Thomas M]
  • (PMID = 20351489.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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38. Travis WD: Advances in neuroendocrine lung tumors. Ann Oncol; 2010 Oct;21 Suppl 7:vii65-71
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  • [Title] Advances in neuroendocrine lung tumors.
  • Pulmonary neuroendocrine (NE) tumors include a spectrum of tumors from the low-grade typical carcinoid (TC) and intermediate-grade atypical carcinoid (AC) to the high-grade large-cell neuroendocrine carcinoma (LCNEC) and small-cell carcinoma (SCLC).
  • Nodular NE proliferations ≥ 0.5 cm are classified as carcinoid tumors and smaller ones are called tumorlets.
  • Carcinoid tumors have significant clinical, epidemiologic and genetic differences from the high-grade SCLC and LCNEC.
  • Also both LCNEC and SCLC can demonstrate histologic heterogeneity with other major histologic types of lung carcinoma such as adenocarcinoma or squamous cell carcinoma, but is not characteristic of TC or AC.
  • The diagnosis of SCLC, TC and AC can be made by light microscopy without the need for special tests in most cases, but for LCNEC it is required to demonstrate NE differentiation by immunohistochemistry or electron microscopy.

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  • (PMID = 20943645.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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39. Pankiewicz W, Minarowski L, Niklińska W, Naumnik W, Nikliński J, Chyczewski L: Immunohistochemical markers of cancerogenesis in the lung. Folia Histochem Cytobiol; 2007;45(2):65-74
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  • [Title] Immunohistochemical markers of cancerogenesis in the lung.
  • Lung cancer is the leading cause of cancer deaths for people of both sexes worldwide.
  • Early diagnosis of precancer lesions may be of crucial significance to lowering lung cancer mortality.
  • The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia and carcinoma in situ, atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
  • These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively.
  • In this review we summarize the data of morphological and cell cycle related proteins changes in both central and peripheral compartments of lung.

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  • (PMID = 17597018.001).
  • [ISSN] 0239-8508
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 67
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40. Lal DR, Clark I, Shalkow J, Downey RJ, Shorter NA, Klimstra DS, La Quaglia MP: Primary epithelial lung malignancies in the pediatric population. Pediatr Blood Cancer; 2005 Oct 15;45(5):683-6
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  • [Title] Primary epithelial lung malignancies in the pediatric population.
  • BACKGROUND: Primary epithelial lung malignancies are rare in childhood and adolescence.
  • We reviewed the Memorial Sloan-Kettering Cancer Center experience with these tumors to better understand their histology, time to diagnosis, treatment, and outcome.
  • PROCEDURE: A retrospective review was performed on all patients 21 years of age or younger at diagnosis, treated for primary epithelial lung malignancies at Memorial Sloan-Kettering Cancer Center between 1980 and 2001.
  • RESULTS: We identified 11 patients with primary epithelial lung malignancy.
  • The median age at diagnosis was 19 (range: 12-21) years.
  • Seven patients (64%) were initially diagnosed as having pneumonia which contributed to a delay in diagnosis.
  • Final pathologic diagnoses included adenocarcinoma (four), carcinoid tumor (three typical, one atypical), basaloid carcinoma (two), and mucoepidermoid carcinoma (one).
  • CONCLUSIONS: When children and adolescents present with primary epithelial lung malignancy a majority will have advanced disease and experience a delay in diagnosis.
  • The histologic types of tumors encountered are similar to lung tumors occurring in adults, although the frequency of the various types differs.
  • Carcinoid tumors are more frequent, and less common subtypes of bronchogenic carcinoma are also more prevalent in the pediatric age group.
  • Patients with carcinoid tumors seem to have the best prognosis, followed by adenocarcinoma.
  • [MeSH-major] Carcinoma / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adolescent. Adult. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Child. Diagnostic Errors. Female. Humans. Male. Pneumonia / diagnosis

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  • (PMID = 15714450.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. De Dosso S, Bajetta E, Procopio G, Cortinovis D, Buzzoni R, Catena L, Platania M, Verzoni E: Pulmonary carcinoid tumours: indolent but not benign. Oncology; 2007;73(3-4):162-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pulmonary carcinoid tumours: indolent but not benign.
  • BACKGROUND: The aim of this retrospective study was to analyse the malignant behaviour of low-grade pulmonary neuroendocrine tumours (NETs) treated at our institution.
  • PATIENTS AND METHODS: We reviewed 48 consecutive patients with pulmonary NETs referred to our Medical Oncology Unit between 1998 and 2006, including 33 subjects with typical carcinoids (TCs) and 15 with atypical carcinoids (ACs).
  • RESULTS: At diagnosis, there were 37 metastatic and 11 non-metastatic patients.
  • [MeSH-major] Carcinoid Tumor / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease Progression. Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18418008.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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42. Rekhtman N: Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med; 2010 Nov;134(11):1628-38
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  • [Title] Neuroendocrine tumors of the lung: an update.
  • CONTEXT: The 2004 World Health Organization (WHO) classification recognizes 4 major types of lung neuroendocrine tumors: typical carcinoid, atypical carcinoid, small cell lung cancer, and large cell neuroendocrine carcinoma.
  • Markedly different prognostic implications and treatment paradigms for these tumors underscore the importance of accurate pathologic diagnosis.
  • OBJECTIVE: To detail the clinical and pathologic features of lung neuroendocrine tumors, with emphasis on diagnostic criteria, differential diagnoses, and application of immunohistochemistry.
  • The emerging evidence for the utility of Ki-67 (MIB1) in the diagnosis of lung neuroendocrine tumors, particularly in small biopsy and cytology, is emphasized.
  • Ki-67 (MIB1) is emerging as a useful ancillary tool in the diagnosis of these tumors.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor. Diagnosis, Differential. Humans. Immunohistochemistry. Prognosis

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  • (PMID = 21043816.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Langfort R, Rudziński P, Burakowska B: [Pulmonary neuroendocrine tumors. The spectrum of histologic subtypes and current concept on diagnosis and treatment]. Pneumonol Alergol Pol; 2010;78(1):33-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pulmonary neuroendocrine tumors. The spectrum of histologic subtypes and current concept on diagnosis and treatment].
  • Neuroendocrine tumors of the lung represent a broad spectrum of morphologic types that share specific morphologic, immunohistochemical, ultrastructural, and molecular characteristics.
  • The classification of neuroendocrine lung tumors has changed over the last decades and currently four categories are distinguished: typical carcinoid tumor, atypical carcinoid tumor, large cell neuroendocrine carcinoma and small cell carcinoma.
  • Neuroendocrine tumors of the lung comprise approximately 20% of all primary lung cancers.
  • Because of differences in clinical behavior, therapy, and prognosis, a reliable histological diagnosis, as well as clinical and pathological staging system are essential for an appropriate medical proceedings.
  • All carcinoids are malignant tumors with the potential to metastasize.
  • The majority of patients with pulmonary carcinoid have an excellent survival, even if they present with lymph node metastases.
  • Large cell neuroendocrine and small cell carcinoma progress rapidly and are generally widespread at the moment of diagnosis.
  • Increased knowledge about pulmonary neuroendocrine tumors biology and the genetic characteristics, imply that carcinoid tumors appear to have a different etiology and pathogenesis than large cell neuroendocrine and small cell carcinoma.
  • In practice, it could be easiest to conceptualize this group of pulmonary tumors as a spectrum of malignancy ranging from the low grade typical carcinoid to the highly malignant large cell neuroendocrine and small cell carcinoma.
  • Typical carcinoid tumors associated with a fairly benign behavior should be classified as low-grade neuroendocrine tumor/carcinoma (G1) and atypical carcinoid tumors as intermediate-grade tumor/carcinoma (G2).
  • Whereas, large cell neuroendocrine and small cell carcinoma should be grouped together under the designation of high-grade neuroendocrine tumor/carcinoma (G3).
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / therapy. Neuroendocrine Tumors / diagnosis. Neuroendocrine Tumors / therapy
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / therapy. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / therapy. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / therapy. Humans. Lung / pathology. Lymphatic Metastasis. Neoplasm Staging. Prognosis. Survival Analysis

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  • (PMID = 20162517.001).
  • [ISSN] 0867-7077
  • [Journal-full-title] Pneumonologia i alergologia polska
  • [ISO-abbreviation] Pneumonol Alergol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 67
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44. Irving JA, Young RH: Lung carcinoma metastatic to the ovary: a clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis. Am J Surg Pathol; 2005 Aug;29(8):997-1006
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  • [Title] Lung carcinoma metastatic to the ovary: a clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis.
  • Thirty-two cases of lung carcinoma metastatic to the ovary in women 26 to 76 years of age (mean, 47 years) are reported.
  • A history of prior lung carcinoma was documented in 53% of cases (17 of 32), with the ovarian tumor detected at a mean interval of 1 year.
  • In 10 cases (31%), the lung and ovarian tumors occurred synchronously, and in 5 (16%) the ovarian tumor was detected up to 26 months before the lung cancer.
  • Forty-four percent of the tumors were small cell carcinomas (14 of 32), 34% adenocarcinomas (11 of 32), and 16% large cell carcinomas (5 of 32); there was a single squamous cell carcinoma and one atypical carcinoid.
  • Thirteen percent of cases (4 of 32) had a coexisting primary ovarian tumor.
  • The mean ovarian tumor size was 9.7 cm, and one third of the ovarian metastases were bilateral.
  • Tumor was limited to the lung and one or both ovaries in 13 cases (40%).
  • Attention to these features, to the usual absence of associated typical surface epithelial neoplasia, and to the clinical history enabled the correct diagnosis to be made in the majority of cases without need of special studies.
  • The differential diagnosis with the primary ovarian tumors most often meriting consideration, including unusual variants of surface epithelial tumors, is discussed.
  • [MeSH-major] Lung Neoplasms / pathology. Ovarian Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adult. Aged. Biomarkers, Tumor / analysis. Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / secondary. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / secondary. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness. Nuclear Proteins / analysis. Time Factors. Transcription Factors / analysis

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  • (PMID = 16006793.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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45. Granberg D, Wilander E, Oberg K: Expression of tyrosine kinase receptors in lung carcinoids. Tumour Biol; 2006;27(3):153-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of tyrosine kinase receptors in lung carcinoids.
  • OBJECTIVES: Typical lung carcinoids are usually relatively benign tumors, but distant metastases are seen in up to 12% of the patients.
  • In contrast, atypical carcinoids are more aggressive tumors, displaying metastases in up to 70%.
  • The current treatment of metastatic lung carcinoids is discouraging.
  • New therapies, such as inhibitors of the tyrosine kinase receptor family c-kit, platelet-derived growth factor receptors (PDGFR) alpha and beta and epidermal growth factor receptor (EGFR) have shown promising results in other malignancies and might be of value in malignant lung carcinoids.
  • PATIENTS AND METHODS: Tumor tissue from 51 patients with typical lung carcinoids were immunostained with polyclonal antibodies against c-kit, PDGFRalpha, PDGFRbeta and EGFR.
  • CONCLUSIONS: Tyrosine kinase receptors such as c-kit, PDGFRalpha, PDGFRbeta and EGFR are expressed in a significant number of patients with metastatic lung carcinoids.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Lung Neoplasms / diagnosis. Receptor Protein-Tyrosine Kinases / analysis

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  • (PMID = 16612146.001).
  • [ISSN] 1010-4283
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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46. Asamura H, Kameya T, Matsuno Y, Noguchi M, Tada H, Ishikawa Y, Yokose T, Jiang SX, Inoue T, Nakagawa K, Tajima K, Nagai K: Neuroendocrine neoplasms of the lung: a prognostic spectrum. J Clin Oncol; 2006 Jan 1;24(1):70-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendocrine neoplasms of the lung: a prognostic spectrum.
  • PURPOSE: Neuroendocrine (NE) tumors of the lung include typical carcinoid (TC), atypical carcinoid (AC), large-cell NE carcinoma (LCNEC), and small-cell lung carcinoma (SCLC).
  • The histologic diagnosis was determined by the consensus of a pathology panel consisting of six expert pathologists as TC, AC, LCNEC, or SCLC on the basis of the WHO classification, and its relationship to clinicopathologic profiles was analyzed.
  • The pathology panel reviewed the remaining 366 tumors, and a diagnosis of NE tumor was made in 318 patients (87.4%); 55 patients had TC, nine had AC, 141 had LCNEC, and 113 had SCLC.
  • [MeSH-major] Lung Neoplasms / mortality. Neuroendocrine Tumors / mortality

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  • (PMID = 16382115.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Peng WX, Sano T, Oyama T, Kawashima O, Nakajima T: Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. Lung Cancer; 2005 Feb;47(2):225-33
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  • [Title] Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma.
  • Large cell neuroendocrine carcinoma (LCNEC) of the lung is a malignant neuroendocrine tumor clinicopathologically similar to and falling in-between atypical carcinoid tumor and small cell lung carcinoma (SCLC).
  • The diagnosis of LCNEC is based mainly on a characteristic neuroendocrine morphology and biological neuroendocrine differentiation.
  • Morphological neuroendocrine differentiation might not be identical to biological neuroendocrine differentiation in large cell carcinoma of the lung.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Small Cell / pathology

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  • (PMID = 15639721.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Retinoblastoma Protein; 68238-35-7 / Keratins
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48. Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM: Bronchopulmonary neuroendocrine tumors. Cancer; 2008 Jul 1;113(1):5-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Bronchopulmonary neuroendocrine tumors (BP-NETs) comprise approximately 20% of all lung cancers and represent a spectrum of tumors arising from neuroendocrine cells of the BP-epithelium.
  • Although they share structural, morphological, immunohistochemical, and ultrastructural features, they are separated into 4 subgroups: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), large-cell neuroendocrine carcinoma (LCNEC), and small-cell lung carcinoma (SCLC), which exhibit considerably different biological characteristics.
  • Less than 5% of BP-NETs exhibit hormonally related symptoms such as carcinoid syndrome, Cushing, acromegaly, and SIADH.
  • SCLC is the most common BP-NET, while LCNEC is rare, approximately 10% and < or =1%, respectively, of all lung cancers.
  • The slow-growing TC exhibit a fairly good prognosis ( approximately 88%, 5-year survival), whereas AC demonstrate a 5-year survival of approximately 50%, and the highly malignant LCNEC and SCLC5-year survival of 15% to 57% and <5%, respectively.
  • [MeSH-major] Lung Neoplasms. Neuroendocrine Tumors
  • [MeSH-minor] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / genetics. Bronchial Neoplasms / pathology. Bronchial Neoplasms / therapy. Carcinoid Tumor / diagnosis. Carcinoid Tumor / genetics. Carcinoid Tumor / pathology. Carcinoid Tumor / therapy. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / genetics. Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / therapy. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / genetics. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / therapy. Humans. Models, Biological. Neoplasm Metastasis. Prognosis

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  • [Copyright] (Copyright) 2008 American Cancer Society.
  • (PMID = 18473355.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 134
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49. Dosios T, Nikou GC, Toubanakis C, Filippides T, Papachristou D: Multimodality treatment of neuroendocrine tumors of the thymus. Thorac Cardiovasc Surg; 2005 Oct;53(5):305-9
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  • Four patients with this tumor who underwent multimodality treatment are presented and the literature is briefly reviewed.
  • All patients underwent extensive excision of the tumor.
  • Histological diagnosis was atypical carcinoid (2), typical carcinoid (1), and small cell carcinoma (1).
  • One patient died 132 months after diagnosis.
  • The remaining three patients are alive with no symptoms at 135, 99, and 35 months, respectively, after diagnosis.
  • [MeSH-minor] Adult. Carcinoid Tumor / classification. Carcinoid Tumor / metabolism. Carcinoid Tumor / therapy. Carcinoma, Small Cell / classification. Carcinoma, Small Cell / metabolism. Carcinoma, Small Cell / therapy. Chemotherapy, Adjuvant. Chromogranin A. Chromogranins / biosynthesis. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunohistochemistry. Liver Neoplasms / metabolism. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Lung Neoplasms / metabolism. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / secondary. Phosphopyruvate Hydratase / biosynthesis. Radiotherapy, Adjuvant. Surgical Procedures, Operative. Synaptophysin / biosynthesis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16208618.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Chromogranins; 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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50. Brokx HA, Risse EK, Paul MA, Grünberg K, Golding RP, Kunst PW, Eerenberg JP, van Mourik JC, Postmus PE, Mooi WJ, Sutedja TG: Initial bronchoscopic treatment for patients with intraluminal bronchial carcinoids. J Thorac Cardiovasc Surg; 2007 Apr;133(4):973-8
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Carcinoid of the lung is considered low-grade malignancy, and less invasive treatment may therefore be considered.
  • For intraluminal bronchial carcinoid, complete tumor eradication with initial bronchoscopic treatment was attempted.
  • High-resolution computed tomography in addition to bronchoscopy was used to determine intraluminal versus extraluminal tumor growth.
  • Surgery followed in cases of atypical carcinoid, residue, or recurrence.
  • Fifty-seven (79%) had typical carcinoids and 15 (21%) had atypical carcinoids.
  • Initial bronchoscopic treatment resulted in complete tumor eradication in 33 of 72 cases (46%), 30 typical and 3 atypical.
  • Thirty-seven of 72 cases (51%), 11 atypical, required surgery (2 for late detected recurrences).
  • Two patients had metastatic atypical carcinoid, 1 already at referral.
  • Of the 6 deaths, 1 was tumor related.
  • For successful tumor eradication with initial bronchoscopic treatment in central carcinoids, assessment of intraluminal versus extraluminal growth may be of much more importance than histologic division between typical and atypical carcinoid.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / surgery. Bronchoscopy. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery

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  • (PMID = 17382637.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Srirajaskanthan R, Toumpanakis C, Karpathakis A, Marelli L, Quigley AM, Dusmet M, Meyer T, Caplin ME: Surgical management and palliative treatment in bronchial neuroendocrine tumours: a clinical study of 45 patients. Lung Cancer; 2009 Jul;65(1):68-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Bronchial neuroendocrine tumours account for 1-2% of all lung cancers; they are thought to arise from the neuroendocrine cells located in the bronchial mucosa.
  • Histological diagnosis from our department was available for 39 patients, with the remainder having had histological assessment performed previously.
  • Typical carcinoid was present in 25 cases, atypical in 9 cases, large cell neuroendocrine carcinoma in 4 and 1 case of small cell lung carcinoma.
  • All patients were staged at time of initial diagnosis with CT scan, in addition Octreoscans were performed when appropriate.
  • Somatostatin analogues were used as first line therapy in six patients, for symptom control and anti-tumour effect.
  • [MeSH-major] Bronchial Neoplasms / therapy. Carcinoid Tumor / therapy. Palliative Care / methods

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  • (PMID = 19070398.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
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52. Warth A, Krysa S, Zahel T, Hoffmann H, Schirmacher P, Schnabel PA, Herpel E: [S100 protein positive sustentacular cells in pulmonary carcinoids and thoracic paragangliomas: differential diagnostic and prognostic evaluation]. Pathologe; 2010 Sep;31(5):379-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In order to get more insight into the prevalence as well as the prognostic and differential diagnostic value of this cell population in pulmonary carcinoids, we investigated a panel of 26 tumorlets, 147 typical and atypical pulmonary carcinoids and ten thoracic paragangliomas immunohistochemically.
  • Hence, the presence and distribution of these cells does not appear to represent a reliable criterion in differential diagnosis.
  • Moreover, all pulmonary carcinoid patients with a worse outcome had low numbers of or no S100 protein positive cells in their tissue specimens.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology. Epithelial Cells / pathology. Lung Neoplasms / pathology. Paraganglioma / pathology. S100 Proteins / analysis. Thoracic Neoplasms / pathology
  • [MeSH-minor] Biopsy. Cell Count. Diagnosis, Differential. Glomus Jugulare Tumor / pathology. Humans. Immunoenzyme Techniques. Lung / pathology. Predictive Value of Tests. Prognosis

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  • (PMID = 20567830.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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53. Ferolla P, Daddi N, Urbani M, Semeraro A, Ribacchi R, Giovenali P, Ascani S, De Angelis V, Crinò L, Puma F, Daddi G, Regional Multidisciplinary Group for the Diagnosis and Treatment of Neuroendocrine Tumors, CRO, Umbria Region Cancer Network, Italy: Tumorlets, multicentric carcinoids, lymph-nodal metastases, and long-term behavior in bronchial carcinoids. J Thorac Oncol; 2009 Mar;4(3):383-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: Nodal dissection and serial sections of resected lung parenchima for research of multicentric forms and tumorlets were performed in most patients.
  • RESULTS: Lymph-node involvement was present in 14% of typical (14 of 100) and 13.04% of atypical carcinoids (3 of 23).
  • Overall survival was 98.2%, 95.8%, and 83.9% for typical and 71.6%, 57.3%, and 24% for atypical carcinoid respectively at 5, 10, and 15 years.
  • [MeSH-major] Bronchial Neoplasms / mortality. Bronchial Neoplasms / pathology. Carcinoid Tumor / mortality. Carcinoid Tumor / secondary. Lymph Nodes / pathology. Neoplastic Cells, Circulating / pathology

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  • (PMID = 19247084.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Shilo K, Dracheva T, Mani H, Fukuoka J, Sesterhenn IA, Chu WS, Shih JH, Jen J, Travis WD, Franks TJ: Alpha-methylacyl CoA racemase in pulmonary adenocarcinoma, squamous cell carcinoma, and neuroendocrine tumors: expression and survival analysis. Arch Pathol Lab Med; 2007 Oct;131(10):1555-60
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AMACR serves as a useful marker in establishing a diagnosis of prostatic malignancy; however, limited information is available in regard to its presence in pulmonary neoplasms.
  • OBJECTIVE: To investigate AMACR expression within a spectrum of lung carcinomas and its correlation with patients' survival.
  • DESIGN: Four hundred seventy-seven pulmonary carcinomas, including 150 squamous cell carcinomas, 150 adenocarcinomas, 46 typical carcinoids, 31 atypical carcinoids, 28 large cell neuroendocrine carcinomas, and 72 small cell carcinomas, were studied immunohistochemically using tissue microarray-based samples.
  • Among tumor types, 22% of squamous cell carcinoma, 56% of adenocarcinoma, 72% of typical carcinoid, 52% of atypical carcinoid, 70% of large cell neuroendocrine carcinoma, and 51% of small cell lung carcinoma were positive for AMACR.
  • Additionally, its positive correlation with outcome of stage I-II small cell lung carcinoma warrants further investigation of the AMACR role in the prognosis of this tumor.
  • [MeSH-major] Adenocarcinoma / enzymology. Biomarkers, Tumor / metabolism. Carcinoma, Neuroendocrine / enzymology. Carcinoma, Squamous Cell / enzymology. Lung Neoplasms / enzymology. Racemases and Epimerases / metabolism

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  • (PMID = 17922592.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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55. Capelli M, Bertino G, Morbini P, Villa C, Zorzi S, Benazzo M: Neuroendocrine carcinomas of the upper airways: a small case series with histopathological considerations. Tumori; 2007 Sep-Oct;93(5):499-503
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diagnosis requires the recognition of the typical neuroendocrine architecture and morphology and the immunohistochemical confirmation of neuroendocrine differentiation.
  • In the 1991 WHO classification laryngeal neuroendocrine carcinomas have been divided into carcinoids, atypical carcinoids, small cell carcinomas and paragangliomas.
  • Atypical carcinoids in the head and neck region usually show an aggressive behavior analogous to poorly differentiated carcinomas, and are resistant to chemo- and radiotherapy.
  • The patient with small cell carcinoma was free from disease 26 months after radical surgery, while the other patients showed liver, lung and bone metastases 18, 26 and 24 months after the diagnosis despite radical surgery or concomitant intra-arterial chemotherapy and radiotherapy.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Lung Neoplasms / pathology. Neuroendocrine Tumors / pathology. Oropharyngeal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoid Tumor / pathology. Carcinoid Tumor / therapy. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / therapy. Combined Modality Therapy. Humans. Immunoenzyme Techniques. Male. Middle Aged

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  • (PMID = 18038886.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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56. Brambilla E, Lantuejoul S: [Thoracic neuroendocrine tumors]. Ann Pathol; 2005 Dec;25(6):529-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The typical carcinoids are of low grade, the atypical carcinoids of intermediate grade and the large cell neuroendocrine carcinoma with the small cell carcinoma are high grade neuroendocrine tumors.
  • [MeSH-major] Lung Neoplasms / pathology. Neuroendocrine Tumors / pathology. Thoracic Neoplasms / pathology
  • [MeSH-minor] Biopsy. Carcinoid Tumor / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / ultrastructure. Diagnosis, Differential. Humans. Prognosis

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  • (PMID = 16735977.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 72
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57. Chong S, Lee KS, Kim BT, Choi JY, Yi CA, Chung MJ, Oh DK, Lee JY: Integrated PET/CT of pulmonary neuroendocrine tumors: diagnostic and prognostic implications. AJR Am J Roentgenol; 2007 May;188(5):1223-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Maximum SUVs of carcinoid tumors, large-cell neuroendocrine carcinomas (LCNECs), and small-cell lung carcinomas (SCLCs) were compared, and maximum SUV and tumor stage and prognosis were correlated.
  • RESULTS: Four (two typical and two atypical) of the seven carcinoid tumors had no FDG uptake or less than mediastinal uptake.
  • There was no significant correlation between maximum SUV of the primary tumor and the tumor stages of carcinoids, LCNECs, or SCLCs (p = 0.08, Jonckheere-Terpstra test; p = 0.768, Mann-Whitney test).
  • CONCLUSION: The maximum SUVs of neuroendocrine tumors are significantly different for carcinoid tumors, LCNECs, and SCLCs, and a high maximum SUV suggests short survival of patients with LCNEC or SCLC.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 17449764.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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58. Abdel Rahman AR: Bronchoplasty for primary broncho-pulmonary tumors. J Egypt Natl Canc Inst; 2010 Mar;22(1):73-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Between 2000 and 2009, 36 patients with primary lung tumors required bronchoplasty were retrospectively analyzed.
  • Pre operative diagnosis was acheived by bronchoscopy for all patients, mediastinoscopy was done for patients with primary lung cancer.
  • Neo adjuvant chemotherapy was given for 6 patients with non small cell lung cancer (NSCLC).
  • Post operative pathology revealed: 27 patients with typical carcinoid, 2 with atypical carcinoid, 4 with squamous cell carcinoma, 2 with adenocarcinoma and one with hamartoma.
  • One patient with lung cancer developed bone metastases and was alive with disease, while the remaining 30 patients were alive and disease free.
  • CONCLUSION: Bronchoplastic resections achieve local control and long-term survival comparable to the standard resections in patients with carcinoid tumor and NSCLC in anatomically suited lesions.
  • KEY WORDS: Bronchoplasty - Primary - Lung - Tumors.

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  • (PMID = 21503009.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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