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1. Simsek I, Pay S, Dinc A, Erdem H, Kurt B: Atypical carcinoid tumor of the thymus with ectopic ACTH production developed during the course of etanercept treatment--case report. Clin Rheumatol; 2007 Sep;26(9):1561-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical carcinoid tumor of the thymus with ectopic ACTH production developed during the course of etanercept treatment--case report.
  • Ever since the introduction of anti-tumor necrosis factor (TNF) agents, concerns have been raised regarding their potential for developing malignancy.
  • We report the development of thymic atypical carcinoid tumor 9 months after the initiation of etanercept therapy in a patient having refractory spondylarthritis.
  • This case indicates the need for following large cohorts of patients receiving anti-TNF agents to address the long-term effect of these agents on malignancies.
  • [MeSH-major] Antibodies, Monoclonal / adverse effects. Carcinoid Tumor / chemically induced. Immunoglobulin G / adverse effects. Thymus Neoplasms / chemically induced. Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • [MeSH-minor] Adult. Etanercept. Humans. Male. Pituitary ACTH Hypersecretion / etiology. Receptors, Tumor Necrosis Factor. Spondylarthritis / drug therapy

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  • (PMID = 17061154.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
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2. Davì MV, Bodei L, Francia G, Bartolomei M, Oliani C, Scilanga L, Reghellin D, Falconi M, Paganelli G, Lo Cascio V, Ferdeghini M: Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). J Endocrinol Invest; 2006 Jun;29(6):563-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid).
  • It is well known that some procedures performed in diagnostic and therapeutic management of endocrine tumors, such as agobiopsy and hepatic chemoembolization, can be associated with the occurrence of symptoms related to the release of vasoactive amines and/or hormonal peptides from tumor cell lysis.
  • This is the first report of a severe carcinoid crisis developed after receptor radionuclide therapy with 90Y-DOTATOC administered in a patient affected by liver metastases from bronchial neuroendocrine tumor (atypical carcinoid).
  • The patient received iv infusion of octreotide associated with H1 and H2 receptor antagonists and corticosteroid therapy, which induced symptom remission within few days.
  • The case here reported confirms that radionuclide therapy is highly effective in determining early rupture of metastatic tissue and also suggests that pre-medication should be implemented before the radiopeptide administration associated with a close monitoring of the patient in the following days.
  • [MeSH-major] Bronchial Neoplasms / pathology. Liver Neoplasms / secondary. Malignant Carcinoid Syndrome / chemically induced. Octreotide / analogs & derivatives
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Carcinoid Tumor / drug therapy. Carcinoid Tumor / radiotherapy. Humans. Male. Yttrium Radioisotopes / adverse effects

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  • (PMID = 16840837.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / 90Y-octreotide, DOTA-Tyr(3)-; 0 / Yttrium Radioisotopes; RWM8CCW8GP / Octreotide
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3. Auer J, Kirchgatterer A, Berent R, Allinger S, Hinterholzer G, Höbling W, Meindl S, Oppitz P, Kalchmair J, Neuwirth G, Knoflach P: [Gastrointestinal hemorrhage needing blood transfusion as the first manifestation of small bowel carcinoid tumor]. Z Gastroenterol; 2000 Aug;38(8):631-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gastrointestinal hemorrhage needing blood transfusion as the first manifestation of small bowel carcinoid tumor].
  • Carcinoid tumors arise from enterochromaffin or enterochromaffin-like cells that are present in the gastrointestinal tract, ovaries, and lungs.
  • Carcinoid syndrome is associated with small intestine carcinoids in about 40%.
  • Upper gastrointestinal bleeding with melaena or hematochezia is a relatively rare early symptom of patients with small intestine carcinoid tumors.
  • Laparotomy revealed bleeding from a small submucosal malignant carcinoid tumor in small intestine and multiple large metastases within mesenteric tissue.
  • Small intestinal carcinoid tumor has to be considered as a rare cause of gastrointestinal bleeding with melaena or hematochezia.
  • Nevertheless, bleeding is a relatively rare early symptom of patients with small intestine carcinoid tumor.
  • [MeSH-major] Blood Transfusion. Carcinoid Tumor / diagnosis. Gastrointestinal Hemorrhage / etiology. Intestinal Neoplasms / diagnosis. Intestine, Small
  • [MeSH-minor] Acenocoumarol / administration & dosage. Acenocoumarol / adverse effects. Aged. Diagnosis, Differential. Humans. Male. Protein S Deficiency / drug therapy. Protein S Deficiency / genetics. Recurrence


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4. Takahashi T, Hatao K, Yamashita Y, Tanizawa Y: Ectopic ACTH syndrome due to thymic atypical carcinoid treated with combination chemotherapy of cisplatin and etoposide. Intern Med; 2003 Dec;42(12):1197-201
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  • [Title] Ectopic ACTH syndrome due to thymic atypical carcinoid treated with combination chemotherapy of cisplatin and etoposide.
  • A 21-year-old woman with Cushing's syndrome presented with a mediastinal tumor.
  • Ectopic ACTH syndrome was diagnosed and the tumor was resected.
  • The histopathological diagnosis was thymic atypical carcinoid.
  • Despite all tumor lesions having been resected, the tumor relapsed and multiple metastatic lesions grew aggressively.
  • Combination chemotherapy with cisplatin and etoposide (VP16) was administered to control tumor progression, and achieved marked therapeutic effects.
  • Maintenance chemotherapy with carboplatin and VP16 achieved long-term tumor control.
  • This case indicates that some patients with atypical carcinoid tumor are good responders to chemotherapy with platinum agents and VP16.
  • [MeSH-major] ACTH Syndrome, Ectopic / etiology. Antineoplastic Agents, Phytogenic / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoid Tumor / drug therapy. Cisplatin / administration & dosage. Etoposide / administration & dosage. Thymus Neoplasms / drug therapy

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  • (PMID = 14714958.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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5. Meyers MO, Anthony LB, McCarthy KE, Drouant G, Maloney TJ, Espanan GD, Woltering EA: High-dose indium 111In pentetreotide radiotherapy for metastatic atypical carcinoid tumor. South Med J; 2000 Aug;93(8):809-11
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  • [Title] High-dose indium 111In pentetreotide radiotherapy for metastatic atypical carcinoid tumor.
  • Our 35-year-old patient had atypical carcinoid tumor metastatic to cervical, supraclavicular, mediastinal, and mesenteric lymph nodes and to the liver and bone.
  • After a diagnostic 111In-pentetreotide scan, the patient was given eight courses (180 mCi each) of 111In-pentetreotide therapy to selectively target somatostatin receptor-expressing tumor cells.
  • [MeSH-major] Bone Neoplasms / radiotherapy. Bone Neoplasms / secondary. Carcinoid Tumor / radiotherapy. Carcinoid Tumor / secondary. Liver Neoplasms / radiotherapy. Liver Neoplasms / secondary. Lymphatic Metastasis / radiotherapy. Somatostatin / analogs & derivatives
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Female. Humans. Ifosfamide / administration & dosage. Receptors, Somatostatin / analysis. Receptors, Somatostatin / drug effects

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  • (PMID = 10963516.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Receptors, Somatostatin; 51110-01-1 / Somatostatin; 6PLQ3CP4P3 / Etoposide; G083B71P98 / pentetreotide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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6. Spaggiari L, D' Aiuto M, Veronesi G, Pelosi G, de Pas T, Catalano G, de Braud F: Extended pneumonectomy with partial resection of the left atrium, without cardiopulmonary bypass, for lung cancer. Ann Thorac Surg; 2005 Jan;79(1):234-40
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  • The were 10 squamous cell carcinomas (60%), 2 adenocarcinomas, 1 adenosquamous carcinoma, 1 mucoepidermoid carcinoma, and 1 atypical carcinoid tumor.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / mortality. Adenocarcinoma / surgery. Adult. Aged. Antineoplastic Agents / therapeutic use. Arrhythmias, Cardiac / epidemiology. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / surgery. Cardiopulmonary Bypass. Combined Modality Therapy. Databases, Factual. Female. Humans. Length of Stay / statistics & numerical data. Life Tables. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Postoperative Complications / epidemiology. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 15620949.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 11
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