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1. Bonaventure T, Cormier B, Lebas P, Bonneau C, Michenet P: [Benign papilloma: is US-guided vacuum-assisted breast biopsy an alternative to surgical biopsy?]. J Radiol; 2007 Sep;88(9 Pt 1):1165-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign papilloma: is US-guided vacuum-assisted breast biopsy an alternative to surgical biopsy?].
  • The purpose of this study is to assess the value of US guided vacuum-assisted breast biopsy compared to surgery for management of intraductal papilloma.
  • In one case, atypical ductal hyperplasia was present at the periphery of the papilloma, requiring complementary surgery.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Papilloma, Intraductal / pathology. Ultrasonography, Interventional

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  • (PMID = 17878878.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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2. Jaffer S, Nagi C, Bleiweiss IJ: Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy. Cancer; 2009 Jul 1;115(13):2837-43
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  • [Title] Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy.
  • The diagnoses on excision were as follows: intraductal papillomas = 71 cases (68.3%), no residual intraductal papillomas = 16 (15.3%), atypical duct hyperplasia = 8 (7.7%), ductal carcinoma in situ = 6 (5.8%), and invasive carcinoma = 3 (2.9%).
  • In cases with atypical duct hyperplasia or ductal carcinoma in situ, a spectrum of histologic changes ranging from florid to atypical duct hyperplasia (14 cases), to ductal carcinoma in situ (6 cases) were present, all involving intraductal papillomas.
  • [MeSH-major] Breast Neoplasms / surgery. Papilloma, Intraductal / surgery

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  • (PMID = 19402174.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Kabat GC, Jones JG, Olson N, Negassa A, Duggan C, Ginsberg M, Kandel RA, Glass AG, Rohan TE: A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer. Cancer Causes Control; 2010 Jun;21(6):821-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.
  • OBJECTIVE: We used a nested case-control design within a large, multi-center cohort of women who underwent a biopsy for benign breast disease (BBD) to assess the association of broad histologic groupings and specific histologic entities with risk of breast cancer.
  • METHODS: Cases were all women who had a biopsy for BBD and who subsequently developed breast cancer; controls were individually matched to cases and were women with a biopsy for BBD who did not develop breast cancer in the same follow-up interval as that for the cases.
  • RESULTS: Relative to non-proliferative BBD/normal pathology, the multivariable-adjusted odds ratio for proliferative lesions without atypia was 1.45 (95% CI 1.10-1.90), and that for atypical hyperplasia was 5.27 (95% CI 2.29-12.15).
  • The presence of multiple foci of columnar cell hyperplasia and of complex fibroadenoma without atypia was associated with a non-significantly increased risk of breast cancer, whereas sclerosing adenosis, radial scar, and papilloma showed no association with risk.
  • CONCLUSION: Our results indicate that, compared to women with normal pathology/non-proliferative disease, women with proliferative disease without atypia have a modestly increased risk of breast cancer, whereas women with atypical hyperplasia have a substantially increased risk.

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  • (PMID = 20084540.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA095661-01; United States / NCI NIH HHS / CA / R01 CA095661; United States / NCI NIH HHS / CA / R01 CA095661-01; United States / NCI NIH HHS / CA / R01-CA95661-01
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS190315; NLM/ PMC2873161
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4. Ko ES, Cho N, Cha JH, Park JS, Kim SM, Moon WK: Sonographically-guided 14-gauge core needle biopsy for papillary lesions of the breast. Korean J Radiol; 2007 May-Jun;8(3):206-11
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  • [Title] Sonographically-guided 14-gauge core needle biopsy for papillary lesions of the breast.
  • OBJECTIVE: We wanted to assess the need for surgical excising papillary lesions of the breast that were diagnosed upon sonographically guided 14-gauge core needle biopsy.
  • RESULTS: Core needle biopsies of 69 lesions yielded tissue that was classified as benign for 43 lesions, atypical for 18 lesions and malignant for eight lesions.
  • Of the 43 lesions that yielded benign papilloma upon core needle biopsy, one had intraductal papillary carcinoma found upon surgery.
  • Surgical excision was performed for 17 atypical papillary lesions, and this revealed intraductal (n = 6) or invasive (n = 2) papillary carcinoma in 8 (47%) lesions.
  • CONCLUSION: Our results suggest that papillary lesions of the breast that are diagnosed as benign upon sonographically guided 14-gauge core needle biopsy can be followed when the results are concordant with the imaging findings.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Papilloma, Intraductal / pathology. Ultrasonography, Interventional

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  • (PMID = 17554187.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627411
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5. Manfrin E, Mariotto R, Remo A, Reghellin D, Falsirollo F, Dalfior D, Bricolo P, Piazzola E, Bonetti F: Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004). Cancer; 2009 Feb 1;115(3):499-507
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004).
  • BACKGROUND: Cytology and core-needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory.
  • The authors of this report evaluated the impact of the screen-detected BBL at risk of developing cancer that were counted in the quota of benign breast open biopsies in the Breast Cancer Screening Program of Verona.
  • METHODS: Benign open biopsies were subdivided into 4 groups according to their risk of developing cancer: Histo1, normal histology; Histo2, 'pure' BBL (fibroadenoma, fibrocystic disease, mastitis, adenosis); Histo3, BBL with a low risk of developing cancer (radial scar, papilloma, papillomatosis, phyllodes tumor, mucocele-like lesion); and Histo4, BBL with a high risk of developing cancer (atypical columnar cell hyperplasia, atypical ductal hyperplasia, atypical lobular hyperplasia).
  • [MeSH-major] Biopsy / methods. Breast Diseases / complications. Breast Neoplasms / diagnosis


6. Ng CH, Nur-Aishah T, Yip CH: Is it Necessary to Excise All Breast Lesions? Experience from a University-Based Breast Unit. Malays Fam Physician; 2009;4(2-3):66-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is it Necessary to Excise All Breast Lesions? Experience from a University-Based Breast Unit.
  • BACKGROUND: Breast cancer is becoming more important in Asia since it affect the younger age group.
  • Question arises whether it is safe for breast lesions to be left in-situ if all the elements in triple assessment are benign.
  • The aim of this study is to audit all the excision biopsies of breast lumps done in the University Malaya Medical Centre (UMMC), to review the association of age with the type of pathological finding and to evaluate the rate of carcinoma in these biopsies.
  • METHODS: We conducted a retrospective study of all women who had excision biopsy of a breast lump in the University Malaya Medical Centre from January 2005 to December 2006.
  • RESULTS: Of 717 lesions in 664 patients, 459 (64%) were fibroadenoma, 114 (15.9%) were fibrocystic disease, 20 (2.8%) were phylloides tumour, 27 (3.8%) were papilloma, 59 (8.2%) were malignant and 38 (5.3%) were of other pathology.
  • The incidence of fibroadenoma decreased with increasing age and the incidence of fibrocystic changes and papilloma increased with increasing age.
  • Out of the 56 lesions where FNAC/CNB were done, 23 (41.1%) were reported as benign, 20 (35.7%) as suspicious, 4 (7.1%) as atypical, 5 (8.9%) as inadequate, 2 (3.6%) as equivocal and 2 (3.6%) as lymphoid lesions.
  • It is recommended that all women above the age of 40 presenting with a palpable breast lump or a suspicious non-palpable abnormality on screening mammogram to have their lump excised even though the lump is benign on FNAC or CNB.
  • However, women age of 30 to 39 should also have the lump excised in the presence of other risk factors such as family history of breast cancer.

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  • (PMID = 25606166.001).
  • [ISSN] 1985-207X
  • [Journal-full-title] Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia
  • [ISO-abbreviation] Malays Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC4267038
  • [Keywords] NOTNLM ; Breast lump / FNAC / breast cancer / excision biopsy / health care service
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7. Lewis JT, Hartmann LC, Vierkant RA, Maloney SD, Shane Pankratz V, Allers TM, Frost MH, Visscher DW: An analysis of breast cancer risk in women with single, multiple, and atypical papilloma. Am J Surg Pathol; 2006 Jun;30(6):665-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An analysis of breast cancer risk in women with single, multiple, and atypical papilloma.
  • Breast papillomas may be single or multiple and associated with atypical ductal or lobular hyperplasias (ADH/ALH).
  • The risk of breast carcinoma development in patients with papillomas, particularly those with multiple or atypical lesions, is incompletely defined.
  • Fibrocystic lesions were histopathologically classified in a benign breast disease cohort of 9155 who underwent biopsy from 1967 to 1991, with papilloma assessment in 9108.
  • Individuals with papillomas (N=480) were classified into 4 groups: single papilloma (SP, N=372), single papilloma with ADH or ALH (SP+A, N=54), multiple (>5) papillomas (MP, N=41), and multiple papillomas with ADH or ALH (MP+A, N=13).
  • Those without papillomas were classified as nonproliferative (NP, N=6053), proliferative without atypia (PDWA, N=2308), and ADH/ALH [atypical hyperplasia (AH), N=267].
  • The relative risk of breast cancer development associated with SP [2.04, 95% confidence interval (CI) 1.43-2.81] was greater than NP (1.28, 95% CI 1.16-1.42) but similar to PDWA (1.90, 95% CI 1.66-2.16).
  • The risk associated with SP+A (5.11, 95% CI 2.64-8.92) was highly elevated but not substantively different than atypical hyperplasia (4.17, 95% CI 3.10-5.50).
  • There was a marginal increase in breast cancer risk (16%) among patients with proliferative disease if a papilloma was present, but this did not reach statistical significance (P=0.29).
  • The observed frequency of ipsilateral (vs. contralateral) breast cancer development in papilloma subsets was not significantly different than other patient groups.
  • The presence of papilloma in, or associated with, atypia does not modify the risk connotation of ADH/ALH overall.
  • MP constitutes a proliferative breast disease subset having unique clinical and biologic behavior.
  • [MeSH-major] Breast Neoplasms / pathology. Papilloma / pathology. Precancerous Conditions / epidemiology. Precancerous Conditions / pathology

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  • (PMID = 16723843.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Greif F, Sharon E, Shechtman I, Morgenstern S, Gutman H: Carcinoma within solitary ductal papilloma of the breast. Eur J Surg Oncol; 2010 Apr;36(4):384-6
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  • [Title] Carcinoma within solitary ductal papilloma of the breast.
  • BACKGROUND: Solitary ductal papilloma of the breast, traditionally considered a benign disorder, was recently found to have malignant potential, especially when associated with atypical ductal hyperplasia.
  • METHODS: All patients diagnosed with solitary ductal papilloma at a tertiary medical center from 1994 to 2004 were identified by a database search.
  • Background, clinical and pathological data were collected for those with a carcinoma within the papilloma, and their pathological specimens were revised.
  • RESULTS: Of the 3849 breast biopsies performed in our medical center during the study period, 77 (2%) yielded a solitary ductal papilloma.
  • In 12 cases (15.6% of all solitary ductal papillomas; 0.3% of all breast biopsies), a carcinoma was found within the papilloma.
  • CONCLUSION: In the present series, the incidence of carcinoma within solitary ductal papilloma was 15.6%, indicating that solitary ductal papillomas have malignant potential.
  • SUMMARY: Carcinoma within solitary ductal papilloma of the breast was found in 15.6% of all papillomas.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Papilloma, Intraductal / pathology

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19646841.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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9. Youk JH, Kim EK, Kwak JY, Son EJ: Atypical papilloma diagnosed by sonographically guided 14-gauge core needle biopsy of breast mass. AJR Am J Roentgenol; 2010 May;194(5):1397-402
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  • [Title] Atypical papilloma diagnosed by sonographically guided 14-gauge core needle biopsy of breast mass.
  • OBJECTIVE: The purpose of this study was to evaluate the surgical outcome of atypical papilloma diagnosed by sonographically guided 14-gauge core needle biopsy of the breast mass and to determine whether clinical and radiologic features of this lesion could be used to predict an upgrade to malignancy.
  • MATERIALS AND METHODS: We retrospectively reviewed the pathologic results of sonographically guided 14-gauge core needle biopsy for solid breast masses.
  • A total of 30 atypical papillomas diagnosed by this procedure and surgically excised were included in this study.
  • RESULTS: The results of surgical excision in 30 atypical papillomas were malignant in seven (23.3%) cases.
  • CONCLUSION: Atypical papilloma diagnosed by use of sonographically guided 14-gauge core needle biopsy showed a high upgrade rate after surgical excision.
  • Although some sonographic features may be helpful to predict an upgrade to malignancy, atypical papilloma should be excised surgically in any case.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Papilloma / pathology. Papilloma / ultrasonography. Ultrasonography, Interventional / methods. Ultrasonography, Mammary / methods

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  • (PMID = 20410431.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Niu Y, Yu Q, Yu Y, Ding XM, Shi YR: [Clonality of the peripheral papilloma and cancerous cells of breast]. Zhonghua Yi Xue Za Zhi; 2007 Feb 27;87(8):542-5
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  • [Title] [Clonality of the peripheral papilloma and cancerous cells of breast].
  • OBJECTIVE: To study the clonality status of peripheral papilloma (peri-MP), ductal carcinoma in situ (DCIS), and normal tissue of the breast using an assay based on inactivation mosaicism of the length-polymorphic X-chromosomes at the androgen receptor (AR) locus and to explore a reliable way to distinguish the benign and malignant (or pre-malignant) cases judged morphologically.
  • METHODS: Specimens of breast tissues were obtained from 26 cases of peri-PM, 25 cases of peri-PM with atypical ductal hyperplasia (ADH), and 27 cases pf DCIS, 16 cases of developed canceration, and 20 normal women.
  • CONCLUSION: Normal breast tissue and peri-PM show polyclonality and the peri-PM with ADH shows monoclonality.
  • [MeSH-major] Breast Neoplasms / pathology. Papilloma / pathology

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  • (PMID = 17459204.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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11. Liberman L, Tornos C, Huzjan R, Bartella L, Morris EA, Dershaw DD: Is surgical excision warranted after benign, concordant diagnosis of papilloma at percutaneous breast biopsy? AJR Am J Roentgenol; 2006 May;186(5):1328-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is surgical excision warranted after benign, concordant diagnosis of papilloma at percutaneous breast biopsy?
  • OBJECTIVE: The study objective was to determine the cancer frequency in lesions yielding a benign, concordant diagnosis of papilloma at percutaneous breast biopsy.
  • In 50 lesions (1.3%), percutaneous biopsy yielded a benign, concordant diagnosis of papilloma.
  • RESULTS: Cancer was found in five (14%) of the 35 lesions yielding a benign, concordant diagnosis of papilloma at percutaneous biopsy.
  • In six (17%) of 35 lesions, surgery revealed high-risk lesions including atypical ductal hyperplasia (n = 3), radial scar (n = 2), and lobular carcinoma in situ (n = 1).
  • There was a significantly (p = 0.02) higher frequency of cancer or high-risk lesion in women with multiple versus solitary papillomas and a trend (p = 0.09) toward a higher cancer rate in women with versus without a family history of breast cancer.
  • Breast cancer history, menopausal status, mammographic pattern, biopsy method, and removal of imaging target had no significant impact on cancer rate.
  • Lesions yielding a benign, concordant diagnosis of papilloma at percutaneous biopsy may warrant surgical excision.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Papilloma / pathology. Papilloma / surgery

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  • (PMID = 16632727.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Jaffer S, Lin R, Bleiweiss IJ, Nagi C: Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution. Arch Pathol Lab Med; 2008 Dec;132(12):1940-2
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  • [Title] Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution.
  • We report a case of an axillary lymph node containing benign glandular lesions, intraductal papilloma with florid and atypical duct hyperplasia, and ductal carcinoma in situ.
  • We propose 2 theories for the development of the intraductal papilloma: from adjacent benign glandular inclusions, or from displaced epithelial cells from a previous intraductal papilloma in the ipsilateral breast.
  • [MeSH-major] Breast Neoplasms / etiology. Carcinoma, Intraductal, Noninfiltrating / etiology. Papilloma, Intraductal / etiology

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  • (PMID = 19061295.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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13. Liberman L, Holland AE, Marjan D, Murray MP, Bartella L, Morris EA, Dershaw DD, Wynn RT: Underestimation of atypical ductal hyperplasia at MRI-guided 9-gauge vacuum-assisted breast biopsy. AJR Am J Roentgenol; 2007 Mar;188(3):684-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Underestimation of atypical ductal hyperplasia at MRI-guided 9-gauge vacuum-assisted breast biopsy.
  • OBJECTIVE: The purposes of this study were to determine the frequency of diagnosis of atypical ductal hyperplasia (ADH) at MRI-guided 9-gauge vacuum-assisted breast biopsy and to assess the rate of underestimation of ADH at subsequent surgical excision.
  • MATERIALS AND METHODS: We conducted a retrospective review of medical records of 237 lesions consecutively detected with MRI and then subjected to MRI-guided 9-gauge vacuum-assisted breast biopsy during a 33-month period.
  • RESULTS: Histologic analysis of MRI-guided vacuum-assisted breast biopsy specimens yielded ADH without cancer in 15 (6%) of 237 lesions.
  • Among 15 patients in whom vacuum-assisted breast biopsy yielded ADH, the median age was 52 years (range, 46-68 years).
  • Surgical histologic findings were malignancy in five (38%) of the cases, all ductal carcinoma in situ; high-risk lesion in six (46%) of the cases, including ADH without other high-risk lesions (n = 2), ADH and lobular carcinoma in situ (LCIS) (n = 1), ADH, LCIS, and papilloma (n =1), ADH and papilloma (n = 1), and LCIS (n = 1); and benign in two (15%) of the cases.
  • CONCLUSION: ADH without cancer was encountered in 6% of MRI-guided 9-gauge vacuum-assisted breast biopsies.
  • ADH at MRI-guided vacuum-assisted breast biopsy is an indication for surgical excision because of the high (38%) frequency of underestimation of these lesions.
  • [MeSH-major] Biopsy, Needle / statistics & numerical data. Breast Neoplasms / epidemiology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / epidemiology. Carcinoma, Ductal, Breast / pathology. Magnetic Resonance Imaging / statistics & numerical data. Surgery, Computer-Assisted / statistics & numerical data

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  • (PMID = 17312054.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Hungermann D, Decker T, Bürger H, Kersting C, Böcker W: [Papillary tumors of the breast]. Pathologe; 2006 Sep;27(5):350-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Papillary tumors of the breast].
  • The term papilloma applies to benign proliferative epithelial breast lesions with a papillary architecture.
  • Papilloma may occur at any site in the ductal lobular system and according to its localization is subdivided into two types: solitary (central) papilloma which are located in the major nipple/subareolar ducts or large segmental ducts and multiple (peripheral) papillomas in cystically dilated terminal ductal lobular units (TDLU).
  • In a significant number of papillomas atypia can be identified which have to be classified as atypical proliferates of the ductal type.
  • Some 17% of all papilloma are associated with (synchronous) intraductal or invasive carcinoma, but these also act as an indicator for subsequent (metachronous) carcinoma.
  • As a consequence, in minimally invasive biopsy papilloma has to be classified as B3 and usually has to be followed by surgical excision.
  • [MeSH-major] Breast Neoplasms / pathology. Papilloma / pathology

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  • (PMID = 16896678.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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15. Chang JM, Moon WK, Cho N, Han W, Noh DY, Park IA, Jung EJ: Risk of carcinoma after subsequent excision of benign papilloma initially diagnosed with an ultrasound (US)-guided 14-gauge core needle biopsy: a prospective observational study. Eur Radiol; 2010 May;20(5):1093-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of carcinoma after subsequent excision of benign papilloma initially diagnosed with an ultrasound (US)-guided 14-gauge core needle biopsy: a prospective observational study.
  • OBJECTIVE: To prospectively determine the upgrade rate following surgery in benign papilloma initially diagnosed at ultrasound (US)-guided 14-gauge gun biopsy.
  • Surgical excision was recommended where the biopsy indicated benign papilloma, regardless of imaging findings.
  • The upgrade rate to 'atypical' and 'malignancy' was measured on a per-lesion basis.
  • RESULTS: Of the 114 patients, 87 eventually underwent surgery: among the 100 supposed benign papillomas, surgical excision revealed fibrocystic change or no residual lesion in nine cases, intraductal papilloma in 74, atypical papilloma in 13, papillary ductal carcinoma in situ (DCIS) in three and one invasive papillary carcinoma.
  • The upgrade rate for an atypical papilloma or papilloma with adjacent foci of atypical ductal hyperplasia (ADH) and malignancy was 13% (95% CI = 7.1-21.2%) and 4% (95% CI = 1.1-9.9%), respectively.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Papillary / pathology. Ultrasonography, Interventional

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  • (PMID = 19890638.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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16. Mathur SP, Mathur RS, Creasman WT, Underwood PB, Kohler M: Early non-invasive diagnosis of cervical cancer: beyond Pap smears and human papilloma virus (HPV) testing. Cancer Biomark; 2005;1(2-3):183-91
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early non-invasive diagnosis of cervical cancer: beyond Pap smears and human papilloma virus (HPV) testing.
  • However, current diagnostic methods such as Pap smear and human papilloma virus (HPV) testing are insufficient for an early diagnosis of cervical cancer, follow-up on therapy efficacy or to identify the women who might progress to cervical cancer (only about 1-5% of the HPV-positive women will develop cervical cancer).
  • Patients with atypical squamous cells of undetermined significance (ASC-US) clearly need a better screening test.
  • Serum IGF-I, but not IGF-II levels are elevated in other gynecological, breast, lung and prostate cancers.

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  • (PMID = 17192039.001).
  • [ISSN] 1574-0153
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R21 CA92085-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / IGFBP3 protein, human; 0 / Insulin-Like Growth Factor Binding Protein 3; 0 / Insulin-Like Growth Factor Binding Proteins; 67763-96-6 / Insulin-Like Growth Factor I; 67763-97-7 / Insulin-Like Growth Factor II
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17. Ibarra JA: Papillary lesions of the breast. Breast J; 2006 May-Jun;12(3):237-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary lesions of the breast.
  • Papillary lesions of the breast include a variety of benign, atypical, and malignant lesions whose hallmark is the formation of either papillary tufts composed only of epithelium, or true papillary structures with fibrovascular support and epithelium.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Papillary / pathology. Papilloma / pathology

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  • (PMID = 16684322.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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18. Elsheikh TM, Silverman JF: Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature. Am J Surg Pathol; 2005 Apr;29(4):534-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature.
  • Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) diagnosed in core needle biopsy (CNB) are generally regarded as risk indicators for developing invasive ductal or lobular carcinoma in either breast.
  • Only CNB diagnosed as pure LCIS or ALH (not associated with other high-risk lesions such as ADH, radial scar, or papilloma) were included in the study.
  • [MeSH-major] Breast / surgery. Breast Neoplasms / surgery. Carcinoma in Situ / surgery. Carcinoma, Lobular / surgery. Precancerous Conditions / surgery

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  • [CommentIn] Am J Surg Pathol. 2005 Dec;29(12):1684-5; author reply 1685-6 [16327444.001]
  • (PMID = 15767810.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Valdes EK, Tartter PI, Genelus-Dominique E, Guilbaud DA, Rosenbaum-Smith S, Estabrook A: Significance of papillary lesions at percutaneous breast biopsy. Ann Surg Oncol; 2006 Apr;13(4):480-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significance of papillary lesions at percutaneous breast biopsy.
  • BACKGROUND: The management of nonpalpable papillary lesions found in specimens obtained by percutaneous breast biopsy is controversial.
  • We reviewed the treatment of patients found to have papillary lesions by stereotactic, sonographic, or fine-needle aspiration breast biopsy to identify indications for surgical excision.
  • METHODS: Consecutive patients with intraductal papilloma, atypical papilloma/papilloma with atypical ductal hyperplasia, papillary neoplasm, and papillomatosis according to percutaneous breast biopsy were identified from radiology records.
  • CONCLUSIONS: Malignancy is frequently found at surgical excision for papillary lesions found on percutaneous breast biopsy.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Papillary / pathology. Papilloma / pathology
  • [MeSH-minor] Biopsy, Needle / methods. Breast / pathology. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Papilloma, Intraductal / pathology. Papilloma, Intraductal / surgery. Ultrasonography, Mammary

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  • (PMID = 16474908.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Choi YD, Gong GY, Kim MJ, Lee JS, Nam JH, Juhng SW, Choi C: Clinical and cytologic features of papillary neoplasms of the breast. Acta Cytol; 2006 Jan-Feb;50(1):35-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and cytologic features of papillary neoplasms of the breast.
  • OBJECTIVE: To compare the cytologic features benign and malignant papillary breast lesions.
  • STUDY DESIGN: We reviewed the clinical and cytologic features in 29 cases of intraductal papilloma and 26 cases of atypical papilloma or papillary carcinoma that had been diagnosed by histologic examination.
  • The cytologic features evaluated were as follows: bloody background, row of tall columnar cells, naked bipolar nuclei, hemosiderin-laden macrophages, myoepithelial cells, single scattered atypical cells, cellularity, nuclear atypia, nuclear grade, apocrine metaplasia, eosinophilic cytoplasmic granules, papillary clusters, small papillae, cell balls and large sheets.
  • RESULTS: Of the features evaluated, the diameter of the mass, naked bipolar nuclei and cell balls differed significantly between benign and atypical or malignant papillary neoplasms.
  • The average diameter of a benign papillary neoplasm was 1.8 cm, and that of an atypical or malignant papillary neoplasm was 2.2 cm (p = 0.042).
  • Naked bipolar nuclei were found in 27 cases of benign papillary neoplasm (93.1%) versus 19 cases of atypical or malignant papillary neoplasm (73.1%) (p = 0.050).
  • All 6 cases in which cell balls were present and naked bipolar nuclei were absent proved to be atypical or malignant papillary neoplasms.
  • CONCLUSION: Most cytologic features overlapped in benign and atypical or malignant papillary neoplasms.
  • Although they were not pathognomonic, naked bipolar nuclei and cell balls were cytologic features that differed significantly between benign and atypical or malignant papillary neoplasms.
  • When papillary neoplasms of the breast are suspected in a cytologic smear, the combination of clinical examination, mammography and cytologic features should be considered to make the correct diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Papillary / diagnosis. Papilloma, Intraductal / diagnosis

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  • (PMID = 16514838.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Mercado CL, Hamele-Bena D, Oken SM, Singer CI, Cangiarella J: Papillary lesions of the breast at percutaneous core-needle biopsy. Radiology; 2006 Mar;238(3):801-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary lesions of the breast at percutaneous core-needle biopsy.
  • PURPOSE: To retrospectively review the imaging and histologic findings in patients in whom a benign papillary lesion was diagnosed at core-needle breast biopsy.
  • RESULTS: At core-needle biopsy, lesions were diagnosed as papilloma (n = 29), sclerosing papilloma (n = 8), and benign papillary lesions not otherwise specified (n = 6).
  • For the 36 lesions that were surgically excised, histologic follow-up showed no residual lesion in 10, intraductal papilloma in 14, intraductal papillomatosis in two, papilloma with adjacent foci of atypical ductal hyperplasia (ADH) in eight, and well-differentiated papillary ductal carcinoma in situ (DCIS) in two.
  • [MeSH-major] Biopsy, Needle. Breast / pathology. Breast Neoplasms / pathology. Papilloma / pathology

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  • [Copyright] Copyright RSNA, 2006.
  • [CommentIn] Radiology. 2007 Apr;243(1):300-1; author reply 301 [17392265.001]
  • (PMID = 16424237.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Ueng SH, Mezzetti T, Tavassoli FA: Papillary neoplasms of the breast: a review. Arch Pathol Lab Med; 2009 Jun;133(6):893-907
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary neoplasms of the breast: a review.
  • CONTEXT: Interpretation of papillary lesions of the breast remains a challenging task because of the wide morphologic spectrum encountered in the benign, atypical, and malignant subtypes.
  • Furthermore, complete excision of even a fully developed papillary carcinoma confined to a dilated or cystic duct is associated with an excellent prognosis, whereas a complex papilloma extending into multiple branches of a duct may ultimately recur as a carcinoma because of incomplete excision of microscopic foci.
  • The optimal management of localized papillary lesions is complete excision with a small rim of uninvolved breast tissue without any prior needle instrumentation if and when the papillary nature can be determined by imaging.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Papillary / pathology. Papilloma / pathology

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  • [CommentIn] Arch Pathol Lab Med. 2010 Jan;134(1):16 [20073595.001]
  • (PMID = 19492881.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 87
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23. Sohn V, Keylock J, Arthurs Z, Wilson A, Herbert G, Perry J, Eckert M, Smith D, Groo S, Brown T: Breast papillomas in the era of percutaneous needle biopsy. Ann Surg Oncol; 2007 Oct;14(10):2979-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast papillomas in the era of percutaneous needle biopsy.
  • BACKGROUND: The significance of breast papillomas detected on core needle biopsy (CNB) remains unclear.
  • METHODS: In this retrospective review, patients were divided into benign, atypical, or malignant cohorts based on initial results.
  • While patients with malignant or atypical features were encouraged to undergo surgical excision, no standard recommendation was given for benign papillomas.
  • 206 patients were diagnosed with 215 breast papillomas.
  • Average follow-up of those patients not undergoing excision for benign papilloma was 41 months; we had 92 patients with greater than two year follow-up and 57 patients with greater than four year follow-up.
  • Of patients with atypia or malignancy associated with papilloma, there was a 26% and 87% associated rate of malignancy, respectively.
  • CONCLUSIONS: Benign breast papillomas diagnosed by CNB have a low risk of malignancy and do not need excision.
  • [MeSH-major] Breast Neoplasms / pathology. Papilloma, Intraductal / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Breast / pathology. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Female. Humans. Mastectomy, Segmental. Middle Aged. Observation

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  • (PMID = 17549566.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Ichihara S, Fujimoto T, Hashimoto K, Moritani S, Hasegawa M, Yokoi T: Double immunostaining with p63 and high-molecular-weight cytokeratins distinguishes borderline papillary lesions of the breast. Pathol Int; 2007 Mar;57(3):126-32
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  • [Title] Double immunostaining with p63 and high-molecular-weight cytokeratins distinguishes borderline papillary lesions of the breast.
  • Papillary breast lesions remain a source of diagnostic confusion because the full range of epithelial proliferations may arise within, or secondarily involve, papilloma.
  • The expression of p63 and high-molecular-weight cytokeratins (HMWCK) was studied simultaneously in 33 papillary lesions including intraductal papilloma (IP, n = 10), atypical papilloma (AP, n = 8) and intraductal papillary carcinoma (IPC, n = 15) by double immunostaining.
  • These monotonous cells contrasted with the proliferating cells of UDH in papilloma, which had intense purple cytoplasm in a mosaic-like fashion.
  • The present data suggest that the double immunostaining with the two popular antibodies p63 and HMWCK is a useful tool for reproducible classification of papillary breast lesions.
  • [MeSH-major] Breast Neoplasms / metabolism. Carcinoma, Papillary / metabolism. DNA-Binding Proteins / metabolism. Keratins / metabolism. Mammary Glands, Human / metabolism. Papilloma, Intraductal / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / pathology. Female. Fluorescent Antibody Technique, Direct. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Immunoenzyme Techniques. Middle Aged. Molecular Weight. Retrospective Studies. Transcription Factors

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  • (PMID = 17295644.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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25. Tse GM, Tan PH, Moriya T: The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast. J Clin Pathol; 2009 May;62(5):407-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast.
  • Papillary lesions of the breast represent a heterogeneous group with differing biological behaviour.
  • Myoepithelial markers can help in differentiating papilloma from papillary carcinoma, as the former usually shows a continuous layer of myoepithelial cells.
  • Papilloma may frequently be complicated by superimposed different types of epithelial hyperplasia, which range from usual to atypical or even ductal carcinoma in situ, and they many be morphologically similar.
  • A panel of CK5/6, p63 and neuroendocrine markers can be useful in the diagnostic investigation of problematic papillary lesions of the breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Papillary / diagnosis. Papilloma / diagnosis

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  • (PMID = 19126567.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 33
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26. Carder PJ, Garvican J, Haigh I, Liston JC: Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast. Histopathology; 2005 Mar;46(3):320-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Needle core biopsy can reliably distinguish between benign and malignant papillary lesions of the breast.
  • The appropriate management of non-malignant papillary breast lesions detected on needle core biopsy (NCB) is currently uncertain.
  • METHODS AND RESULTS: Forty-seven papillary breast lesions with a histological diagnosis of papilloma, papilloma with atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS), multiple papillomas, 'papillomatosis' or papillary carcinoma (invasive or in situ) were identified from records at the Leeds Breast Screening and Assessment Unit.
  • All excised cases with a previous 'B3' or 'B2' were found benign, although four of the 'B3's derived from papillomata associated with an atypical proliferation amounting to ADH.
  • CONCLUSION: Our results confirm the accuracy of NCB in the diagnosis of screen-detected papillary lesions of the breast.
  • [MeSH-major] Biopsy, Needle / standards. Breast Neoplasms / pathology. Carcinoma, Papillary / pathology. Papilloma / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Breast / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Middle Aged. Reproducibility of Results

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  • [CommentIn] Histopathology. 2006 Jul;49(1):91 [16842253.001]
  • (PMID = 15720418.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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27. Rozen WM, Joseph S, Murphy C: The management of papillary breast lesions on core biopsy: the contentious issues. Clin Breast Cancer; 2007 Jun;7(8):644-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The management of papillary breast lesions on core biopsy: the contentious issues.
  • The management of papillary lesions of the breast diagnosed on core needle biopsy is highly contentious.
  • Papillary lesions are epithelial proliferations of breast tissue and are on a continuum of mutations with atypical hyperplastic lesions and in situ carcinoma.
  • We present a 21-year-old woman with multiple papillary lesions on core biopsy of a breast lesion, and a subsequent excisional biopsy revealing extensive in situ carcinoma of the breast.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Papilloma / pathology

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  • (PMID = 17592679.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Collins LC, Schnitt SJ: Papillary lesions of the breast: selected diagnostic and management issues. Histopathology; 2008 Jan;52(1):20-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary lesions of the breast: selected diagnostic and management issues.
  • The assessment and categorization of papillary lesions remains one of the most challenging areas in breast pathology.
  • In this review, we will focus on several diagnostic and management issues related to papillary breast lesions that are frequently encountered in daily practice.
  • These include: (i) the distinctions among papillomas with atypia (atypical papillomas), papillomas with ductal carcinoma in situ, and papillary ductal carcinoma in situ;.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology
  • [MeSH-minor] Biopsy, Needle. Carcinoma in Situ / diagnosis. Carcinoma in Situ / pathology. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Intraductal, Noninfiltrating / pathology. Diagnosis, Differential. Female. Humans. Papilloma / diagnosis. Papilloma / pathology

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  • (PMID = 18171414.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 30
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29. Ahmadiyeh N, Stoleru MA, Raza S, Lester SC, Golshan M: Management of intraductal papillomas of the breast: an analysis of 129 cases and their outcome. Ann Surg Oncol; 2009 Aug;16(8):2264-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of intraductal papillomas of the breast: an analysis of 129 cases and their outcome.
  • INTRODUCTION: The management of intraductal papillomas of the breast has been controversial; some advocate surgical excision of all lesions despite benign pathologic features, whereas others excise only those specimens with atypia.
  • METHODS: We conducted a retrospective review of 129 core-biopsy-proven papillomas of the breast with atypia (n = 43) and without atypia (n = 86) and determined the rate of missed carcinoma in surgically excised specimen in each group.
  • CONCLUSIONS: Our findings confirm the practice that papillomas with atypical features should be excised, and suggest that in patients with adequate follow-up, benign papillomas may be managed conservatively.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Intraductal, Noninfiltrating / surgery. Papilloma, Intraductal / surgery

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  • (PMID = 19484312.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Doshi DJ, March DE, Crisi GM, Coughlin BF: Complex cystic breast masses: diagnostic approach and imaging-pathologic correlation. Radiographics; 2007 Oct;27 Suppl 1:S53-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complex cystic breast masses: diagnostic approach and imaging-pathologic correlation.
  • Complex cystic breast masses demonstrate both anechoic (cystic) and echogenic (solid) components at ultrasonography (US).
  • Numerous pathologic entities may produce complex cystic breast lesions or may be associated with them, and biopsy is usually indicated.
  • Common benign findings include fibrocystic changes, intraductal or intracystic papilloma without atypia, and fibroadenoma.
  • Common atypical findings include atypical ductal hyperplasia, atypical papilloma, atypical lobular hyperplasia, and lobular carcinoma in situ.
  • [MeSH-major] Breast Diseases / diagnosis. Cysts / diagnosis

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  • [Copyright] Copyright RSNA, 2007.
  • (PMID = 18180235.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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31. Johnson NB, Collins LC: Update on percutaneous needle biopsy of nonmalignant breast lesions. Adv Anat Pathol; 2009 Jul;16(4):183-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Update on percutaneous needle biopsy of nonmalignant breast lesions.
  • Certain nonmalignant lesions encountered on percutaneous breast biopsies pose dilemmas with regard to the most appropriate clinical management subsequent to needle biopsy (ie, surgical excision vs. follow-up).
  • These lesions include columnar cell lesions, atypical ductal hyperplasia, lobular neoplasia, papillary lesions, radial scars, fibroepithelial lesions, and mucocele-like lesions.
  • In addition, magnetic resonance imaging is being used more frequently in breast imaging, resulting in pathologists more often encountering benign biopsies with uncertain imaging correlation.
  • This review focuses on management issues following the diagnosis of nonmalignant lesions diagnosed on percutaneous breast biopsy and highlights imaging terms commonly used in breast radiology reports to facilitate accurate radiologic-pathologic correlation.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology
  • [MeSH-minor] Animals. Calcinosis / diagnosis. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Lobular / pathology. Carcinoma, Papillary / pathology. Female. Fibroadenoma / pathology. Hyperplasia. Magnetic Resonance Imaging. Mammography. Mucocele / pathology. Papilloma / pathology. Patient Selection. Predictive Value of Tests. Sclerosis. Terminology as Topic. Ultrasonography

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  • (PMID = 19546607.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 145
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32. Datrice N, Narula N, Maggard M, Butler J, Hsiang D, Baick C, Lane K: Do breast columnar cell lesions with atypia need to be excised? Am Surg; 2007 Oct;73(10):984-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do breast columnar cell lesions with atypia need to be excised?
  • Columnar cell lesion with atypia (CCLA) is a newly recognized pathologic entity seen in breast specimens.
  • The breast cancer risk associated with this finding is unclear, although CCLA had been found adjacent to both in situ and invasive carcinomas, but the incidence is unknown.
  • Breast specimens from patients with a columnar cell lesion were reviewed by a pathologist for atypia.
  • Five of 11 specimens with CCLA on excisional biopsy had adjacent abnormal pathology: IDC (3), DCIS/LCIS (1), and atypical ductal hyperplasia/papilloma (1).
  • Breast pathologic specimens containing a columnar cell lesion should be carefully examined for atypia.
  • The future risk of breast cancer based on the finding of CCLA alone requires further investigation.
  • [MeSH-major] Breast / pathology. Breast / surgery
  • [MeSH-minor] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Lobular / pathology. Female. Humans. Retrospective Studies. Risk Assessment

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  • (PMID = 17983063.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Eliahou R, Sella T, Allweis T, Samet Y, Libson E, Sklair-Levy M: Magnetic resonance-guided interventional procedures of the breast: initial experience. Isr Med Assoc J; 2009 May;11(5):275-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance-guided interventional procedures of the breast: initial experience.
  • BACKGROUND: Magnetic resonance imaging of the breast has emerged as a valuable imaging tool in addition to conventional imaging modalities.
  • OBJECTIVES: To evaluate our initial clinical experience with MR-guided core needle breast biopsy and MR-guided needle localization.
  • RESULTS: Fifteen (16%) lesions were malignant (9 invasive ductal carcinoma, 2 invasive lobular carcinoma, 4 ductal carcinoma in situ); 7 (7%) lesions were high risk (4 atypical ductal hyperplasia, 3 radial scars); 75 (77%) lesions were benign, mainly fibrocystic changes.
  • Other benign findings were sclerosing adenosis, pseudoangiomatous stromal hyperplasia, fat necrosis, intraductal papilloma, fibroadenoma, capillary hemangioma, and florid ductal hyperplasia.
  • CONCLUSIONS: MR-guided interventional procedures of the breast are accurate, safe and feasible methods for sampling breast lesions detected only by MR and have become a significant tool in the management of certain patients.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Biopsy, Needle / methods. Breast Diseases / diagnosis. Breast Diseases / pathology. Breast Diseases / ultrasonography. Female. Gadolinium. Humans. Middle Aged. Retrospective Studies

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  • (PMID = 19637504.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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34. Lam WW, Chu WC, Tang AP, Tse G, Ma TK: Role of radiologic features in the management of papillary lesions of the breast. AJR Am J Roentgenol; 2006 May;186(5):1322-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of radiologic features in the management of papillary lesions of the breast.
  • OBJECTIVE: The purpose of our study was to assess the role of imaging and core biopsy in the management of patients with papillary lesions of the breast.
  • MATERIALS AND METHODS: Clinical records and mammographic and sonographic findings of 40 women with papillary lesions in the breast were retrieved.
  • There were three papillary carcinomas, 13 papillaryal lesions with carcinoma in situ, one atypical papilloma, four sclerosed papillomata, and 35 papillomata.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Papillary / diagnosis

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  • (PMID = 16632726.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Rizzo M, Lund MJ, Oprea G, Schniederjan M, Wood WC, Mosunjac M: Surgical follow-up and clinical presentation of 142 breast papillary lesions diagnosed by ultrasound-guided core-needle biopsy. Ann Surg Oncol; 2008 Apr;15(4):1040-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical follow-up and clinical presentation of 142 breast papillary lesions diagnosed by ultrasound-guided core-needle biopsy.
  • BACKGROUND: The clinical management of breast intraductal papilloma (IDP) remains controversial.
  • The objective of this study was to survey a large cohort of benign IDP diagnosed on core needle biopsy (CNB) and to evaluate their clinical presentation and potential risk of associated atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), ductal carcinoma in situ (DCIS) or invasive carcinoma as identified by follow-up surgical excision.
  • [MeSH-major] Breast Neoplasms / pathology. Papilloma, Intraductal / pathology. Precancerous Conditions / pathology

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  • (PMID = 18204989.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. Hamed ST, Abdo MH, Ahmed HH: Breast discharge: ultrasound and Doppler evaluation. J Egypt Natl Canc Inst; 2008 Sep;20(3):262-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast discharge: ultrasound and Doppler evaluation.
  • RESULTS: Revision of biopsy specimens of 17 cases with intraluminal masses detected by US revealed: Six cases with intraductal carcinoma, intraductal papilloma in 7 cases, 1 case of ductal papillomatosis.
  • Three cases showed atypical cells: Intraductal papilloma with atypia in 2 cases, proliferative hyperplasia with atypia in one case.
  • Fibro-optic Ductoscopy confirmed the presence of intraductal papilloma in one case, carcinoma in one case, no intraductal masses in the third case.
  • KEY WORDS: Ductography - Nipple discharge - Intraductal carcinoma - Intraductal papilloma - In situ ductal carcinoma - Invasive ductal carcinoma - Duct ectasia - Breast ductoscopy.

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  • (PMID = 20424657.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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37. Ding Y, Ruan Q: The value of p63 and CK5/6 expression in the differential diagnosis of ductal lesions of breast. J Huazhong Univ Sci Technolog Med Sci; 2006;26(4):405-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of p63 and CK5/6 expression in the differential diagnosis of ductal lesions of breast.
  • In order to explore the value of p63, smoothmuscle actin (alpha-SMA) and cytokeratin 5/6 (CK5/6) in the differential diagnosis of ductal lesions of breast, 88 tissue specimens of ductal lesions of breast were collected and examined histologically by HE staining.
  • The results showed that in 38 cases of benign breast lesions, the proliferating cells were all positive for p63 and alpha-SMA.
  • In 38 cases of benign breast lesions, the positive rate of CK5/6 expression was 100%.
  • In 5 cases of atypical ductal hyperplasia, there were few positive cells in the ducts.
  • It was suggested that p63 could serve as a novel specific marker for the identification of breast myoepithelial cells.
  • Simultaneous detection of p63, CK5/6 and alpha-SMA can help increase the diagnostic accuracy of breast diseases.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Keratin-5 / biosynthesis. Keratin-6 / biosynthesis. Membrane Proteins / biosynthesis
  • [MeSH-minor] Breast Diseases / diagnosis. Breast Diseases / metabolism. Diagnosis, Differential. Female. Fibrocystic Breast Disease / diagnosis. Humans. Immunohistochemistry. Papilloma, Intraductal / diagnosis. Papilloma, Intraductal / metabolism. Predictive Value of Tests

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  • [Cites] Mod Pathol. 2002 Apr;15(4):397-405 [11950913.001]
  • [Cites] Virchows Arch. 2003 Jun;442(6):548-54 [12712335.001]
  • [Cites] Histopathology. 2005 Aug;47(2):202-8 [16045782.001]
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  • [Cites] Am J Surg Pathol. 2001 Aug;25(8):1054-60 [11474290.001]
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  • [Cites] In Vivo. 2003 Nov-Dec;17(6):573-6 [14758723.001]
  • (PMID = 17120733.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Keratin-5; 0 / Keratin-6; 0 / Membrane Proteins
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38. Troxell ML, Levine J, Beadling C, Warrick A, Dunlap J, Presnell A, Patterson J, Shukla A, Olson NR, Heinrich MC, Corless CL: High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Mod Pathol; 2010 Jan;23(1):27-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast.
  • Papillary lesions of the breast have an uncertain relationship to the histogenesis of breast carcinoma, and are thus diagnostically and managerially challenging.
  • Molecular genetic studies have provided evidence that ductal carcinoma in situ and even atypical ductal hyperplasia are precursors of invasive carcinoma.
  • We screened papillary breast neoplasms for activating point mutations in PIK3CA, AKT1, and RAS protein-family members, which are common in invasive ductal carcinomas.
  • DNA extracts were prepared from sections of 89 papillary lesions, including 61 benign papillomas (28 without significant hyperplasia; 33 with moderate to florid hyperplasia), 11 papillomas with atypical ductal hyperplasia, 7 papillomas with carcinoma in situ, and 10 papillary carcinomas.
  • Papillomas had more mutations in AKT1 (54%) than in PIK3CA (21%), whereas papillomas with hyperplasia had more PIK3CA (42%) than AKT1 (15%) mutations, as did papillomas with atypical ductal hyperplasia (PIK3CA 45%, AKT1 27%, and NRAS 9%).
  • The 10 papillary carcinomas showed an overall lower frequency of mutations, including 1 with an AKT1 mutation (in a tumor arising from a papilloma), 1 with an NRAS gene mutation (Q61H), and 2 with PIK3CA mutations (1 overlapping with the NRAS Q61H).
  • [MeSH-major] Breast Neoplasms / genetics. Carcinoma, Papillary / genetics. Phosphatidylinositol 3-Kinases / genetics. Proto-Oncogene Proteins c-akt / genetics


39. Xu WG, Wang G, Liu Y, Zou YH, Song JN, Yang XQ, Wang WY: [Expression of vascular endothelial growth factor in different breast tissues and clinical significance thereof]. Zhonghua Yi Xue Za Zhi; 2008 Mar 25;88(12):802-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of vascular endothelial growth factor in different breast tissues and clinical significance thereof].
  • OBJECTIVE: To investigate the differences in the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) count in breast benign affection, breast atypical hyperplasia, and breast carcinoma in situ and to clarify the association of VEGF expression and MVD with the clinicopathological features of these diseases.
  • METHODS: Immunohistochemistry (SP-method) was used to examine the expression of VEGF and MVD count in 100 samples of breast benign affection (including 35 cases of breast fibroid tumor, 35 cases of breast cystic hyperplasia, and 30 cases of intraductal papilloma), and 15 samples of breast atypical hyperplasia, and 25 samples of breast carcinoma in situ, obtained during operation.
  • RESULTS: The positive rate of VEGF of the breast carcinoma in situ group was 56% , significantly higher than hose of the breast benign affection and breast atypical hyperplasia groups (22% and 33% respectively, P < 0.05).
  • However, there was no significant differences in positive rate of VEGF among breast fibroid tumor, breast cystic hyperplasia, and intraductal papilloma (all P > 0.05).
  • The MVD value of the breast carcinoma in situ group was 20.1 +/- 6.1, significantly higher than those of the breast benign affection group and breast atypical hyperplasia groups (14.3 +/- 3.
  • There was no significant differences in MVD value among breast fibroid tumor, breast cystic hyperplasia, and intraductal papilloma (all P > 0.05).
  • CONCLUSION: In breast tumors, angiogenesis is probably mediated mainly by VEGF.
  • The occurrence and progression of breast cancer may be related with the expression of VEGF.
  • [MeSH-major] Breast / metabolism. Breast Neoplasms / metabolism. Carcinoma, Ductal, Breast / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
  • [MeSH-minor] Female. Fibrocystic Breast Disease / blood supply. Fibrocystic Breast Disease / metabolism. Fibrocystic Breast Disease / pathology. Humans. Immunohistochemistry. Neovascularization, Pathologic. Prognosis

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  • (PMID = 18756980.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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40. Sauter ER, Winn JN, Dale PS, Wagner-Mann C: Nipple aspirate fluid color is associated with breast cancer. Cancer Detect Prev; 2006;30(4):322-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nipple aspirate fluid color is associated with breast cancer.
  • BACKGROUND: Fluid can be non-invasively aspirated from the breast nipple (nipple aspirate fluid, NAF).
  • While bloody spontaneous nipple discharge has been linked with breast cancer, the association of NAF color with cancer is not established.
  • Our hypothesis was that red/brown NAF color was associated with breast cancer.
  • The purpose of this study was to assess (1) if red/brown NAF is associated with the presence and progression of breast cancer, (2) the influence of prior needle or surgical biopsy on NAF color, and (3) if an association between NAF color and breast cancer was found, to develop a cancer predictive model including NAF color and cytology, and clinical information.
  • METHODS: Specimens were obtained from 848 breasts between 1999 and 2004 after subjects enrolled in an IRB approved protocol to evaluate biologic markers of breast cancer.
  • RESULTS: Red/brown NAF was associated with breast cancer when considering all samples (p<0.001) and samples from women who did not undergo recent surgery (p=0.005).
  • For the 327 women with NAF collected from both breasts, there was a significant association between red/brown NAF color and the presence of breast cancer (p=0.005).
  • Red/brown NAF was more common in breasts with ductal carcinoma in situ than atypical hyperplasia (p=0.008).
  • The optimal model, included NAF color, cytology, and age, was 92% sensitive and 61% specific in predicting if a woman had breast cancer.
  • CONCLUSIONS: NAF color was associated with the presence of breast cancer and the progression from precancer to cancer in a population of women who presented to a breast cancer evaluation clinic.
  • NAF color contributed to a highly predictive breast cancer detection model.
  • Additional studies are warranted to determine the usefulness of NAF color in the assessment of women who present for breast cancer evaluation.
  • [MeSH-major] Body Fluids / chemistry. Breast Neoplasms / diagnosis. Nipples
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Lobular / diagnosis. Carcinoma, Papillary / diagnosis. Color. Disease Progression. Female. Humans. Hyperplasia / diagnosis. Middle Aged. Neoplasm Invasiveness / pathology. Papilloma / diagnosis. Prognosis. Sensitivity and Specificity

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  • (PMID = 16963197.001).
  • [ISSN] 0361-090X
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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41. Pathmanathan N, Albertini AF, Provan PJ, Milliken JS, Salisbury EL, Bilous AM, Byth K, Balleine RL: Diagnostic evaluation of papillary lesions of the breast on core biopsy. Mod Pathol; 2010 Jul;23(7):1021-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic evaluation of papillary lesions of the breast on core biopsy.
  • The management of asymptomatic intraductal papillary lesions of the breast diagnosed on core biopsy poses a challenge for patients and clinicians, as the distinction between common benign lesions and atypical or malignant varieties may be difficult without formal excision.
  • Comparison of benign, atypical, and malignant lesions revealed that the combination of broad, sclerotic fibrovascular cores, and epithelial CK5/6 staining was most commonly seen in benign papillomas.
  • Ki67 staining revealed striking intralesional heterogeneity, but there was no difference between the high scores of benign, atypical, or malignant lesions (P=0.173).
  • Misclassified cases included 2/27 lesions ultimately diagnosed as benign and 2/2 atypical papillomas.
  • The combined assessment of fibrovascular core thickness and CK5/6 staining on core biopsy distinguished benign from malignant papillary lesions, but did not separate benign from atypical cases.
  • This approach may form a useful addition to the clinicopathologic evaluation of papillary lesions of the breast.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Papillary / pathology. Papilloma, Intraductal / pathology

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  • (PMID = 20473278.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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42. Sauter ER, Klein-Szanto A, Macgibbon B, Ehya H: Nipple aspirate fluid and ductoscopy to detect breast cancer. Diagn Cytopathol; 2010 Apr;38(4):244-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nipple aspirate fluid and ductoscopy to detect breast cancer.
  • We prospectively performed cytologic assessment and image analysis (IA) on matched nipple aspirate fluid (NAF) and mammary ductoscopy (MD) specimens to determine (1) the accuracy of these methods in cancer detection and (2) whether the two collection methods provide complementary information.NAF and MD specimens were collected from 84 breasts from 75 women (nine bilateral samples) who underwent breast surgery.
  • The best predictive model was positive NAF cytology and/or MD cytology combined with IA aneuploidy, which resulted in 55% sensitivity and 100% specificity in breast cancer detection.Cytologic evaluation and IA of NAF and MD specimens are complementary.
  • The presence of atypical cells arising from an intraductal papilloma in ductoscopic specimens is a potential source of false positive diagnosis in patients with nipple discharge.

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  • [Cites] Br J Cancer. 1999 Dec;81(7):1222-7 [10584885.001]
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  • (PMID = 19795490.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA087391-03; United States / NCI NIH HHS / CA / R21 CA087391; United States / NCI NIH HHS / CA / CA-87391; United States / NCI NIH HHS / CA / R21 CA087391-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS141667; NLM/ PMC3390775
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43. Croce S, Bretz-Grenier MF, Mathelin C: [Most common benign epithelial breast diseases: diagnosis, treatment and cancer risk]. Gynecol Obstet Fertil; 2008 Jul-Aug;36(7-8):788-99
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Most common benign epithelial breast diseases: diagnosis, treatment and cancer risk].
  • As a consequence of breast imaging development and increased interventional radiology, benign epithelial breast diseases (BEBD) represent a growing percentage of breast pathology diagnoses.
  • Some BEBD have to be individualized (radial scars, papillomas, complex sclerosing adenosis, lobular intraepithelial neoplasia, flat epithelial atypia, atypical hyperplasia), being preinvasive lesions or markers of increased breast cancer risk, or being associated with suspect radiological aspect.
  • It always allows a complete surgical specimen analysis and therefore a search for atypical or cancerous cells.
  • [MeSH-major] Breast Diseases / radiography. Breast Neoplasms / epidemiology
  • [MeSH-minor] Female. Fibroadenoma / epidemiology. Hamartoma / epidemiology. Humans. Papilloma / epidemiology. Patient Care Team. Radiography / adverse effects. Risk Factors

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  • (PMID = 18650113.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 63
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44. Bennett LE, Ghate SV, Bentley R, Baker JA: Is surgical excision of core biopsy proven benign papillomas of the breast necessary? Acad Radiol; 2010 May;17(5):553-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is surgical excision of core biopsy proven benign papillomas of the breast necessary?
  • RATIONALE AND OBJECTIVES: The aim of this study was to determine if core biopsy-proven benign papillomas of the breast need to be surgically excised.
  • Of the remaining 58 papillary lesions, 50 were found to be atypical at core needle biopsy; 15 of those 50 (29%) were upgraded to malignancies at surgical excision.
  • CONCLUSIONS: Close imaging follow-up rather than excision of core biopsy-proven benign papillomas was adequate given careful imaging-histopathologic correlation and excision of all atypical and discordant lesions.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Mastectomy / methods. Papilloma / pathology. Papilloma / surgery

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  • [Copyright] Copyright 2010 AUR. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Acad Radiol. 2010 May;17(5):545-6 [20380978.001]
  • (PMID = 20223685.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Sydnor MK, Wilson JD, Hijaz TA, Massey HD, Shaw de Paredes ES: Underestimation of the presence of breast carcinoma in papillary lesions initially diagnosed at core-needle biopsy. Radiology; 2007 Jan;242(1):58-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Underestimation of the presence of breast carcinoma in papillary lesions initially diagnosed at core-needle biopsy.
  • PURPOSE: To retrospectively determine the degree of underestimation of breast carcinoma diagnosis in papillary lesions initially diagnosed at core-needle biopsy.
  • Mammographic database review (1994-2003) revealed core biopsy diagnoses of benign papilloma (n=38), atypical papilloma (n=15), sclerotic papilloma (n=6), and micropapilloma (n=4) in 57 women (mean age, 57 years).
  • Patients with in situ or invasive cancer in the same breast or patients without follow-up were excluded.
  • Core pathologic findings associated with malignancy were benign papilloma (n=1), sclerotic papilloma (n=1), micropapilloma (n=2), and atypical papilloma (n=10).
  • Frequency of malignancy was one (3%) of 38 benign papillomas, 10 (67%) of 15 atypical papillomas, two (50%) of four micropapillomas, and one (17%) of six sclerotic papillomas.
  • Low-risk group (micropapillomas and sclerotic and benign papillomas) was compared with high-risk atypical papilloma group.
  • Core findings were associated with malignancy at excision for atypical papilloma (P=.006).
  • CONCLUSION: Benign papilloma diagnosed at core biopsy is infrequently (3%) associated with malignancy; mammographic follow-up is reasonable.
  • Because of the high association with malignancy (67%), diagnosis of atypical papilloma at core biopsy should prompt excision for definitive diagnosis.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / pathology. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Risk Assessment / methods

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  • [Copyright] Copyright (c) RSNA, 2006.
  • (PMID = 17090707.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Cornea V, Jaffer S, Bleiweiss IJ, Nagi C: Adequate histologic sampling of breast magnetic resonance imaging-guided core needle biopsy. Arch Pathol Lab Med; 2009 Dec;133(12):1961-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adequate histologic sampling of breast magnetic resonance imaging-guided core needle biopsy.
  • CONTEXT: -The increasing use of contrast-enhanced magnetic resonance imaging (MRI) of the breast as a valuable adjunct to mammography and ultrasound in the detection of breast lesions, in association with needle core biopsy taken from the suspicious areas, has major workload implications for histopathology laboratories wherever breast MRI is practiced.
  • OBJECTIVE: -To establish the number of histologic levels necessary for the evaluation of breast MRI-guided needle core biopsy specimens taken from suspicious areas on breast MRI examination.
  • DESIGN: -Retrospective histologic review of a series of breast MRI-guided core needle biopsies, initially examined routinely at 4 levels, in the Pathology Department at Mount Sinai School of Medicine in New York, New York.
  • In only a single case (0.2%) was it likely that routine examination of 4 levels could have led to an incidental finding of a very small intraductal papilloma (0.15 cm) present only at the second histologic level.
  • Further levels may be needed in occasional cases to identify more conclusively an associated pathologic abnormality and may be of particular value when assessing atypical intraductal proliferative epithelial lesions.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Magnetic Resonance Imaging / methods

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  • (PMID = 19961252.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Reefy S, Osman H, Chao C, Perry N, Mokbel K: Surgical excision for B3 breast lesions diagnosed by vacuum-assisted core biopsy. Anticancer Res; 2010 Jun;30(6):2287-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical excision for B3 breast lesions diagnosed by vacuum-assisted core biopsy.
  • The aim of this retrospective study was to assess whether open surgical excision is required following a B3 diagnosis on 11-gauge vacuum-assisted core biopsy (VACB) of radiologically indeterminate breast lesions.
  • PATIENTS AND METHODS: Twenty-four women with a histological diagnosis of the B3 category on VACB of radiologically indeterminate breast lesions were identified over a 3-year period.
  • The remaining 5 patients who had 'complete' removal of the radiological abnormality using VACB under ultrasound (n=2, papilloma) or stereotactic (n=4, atypical ductal hyperplasia) guidance were followed up clinically and radiologically.
  • The VACB showed atypical lobular hyperplasia in these 3 patients, associated with microcalcification (n=2) or mass lesion (n=1).
  • No single case of upgrading to invasive breast cancer was identified in our series.
  • The upgrade to malignancy was significantly associated with the presence of atypical lobular hyperplasia, a BI-RADS category of 4 and incomplete removal of the radiological abnormality by VACB.
  • CONCLUSION: Open surgical excision is strongly recommended for atypical lobular hyperplasia identified in VACB specimens.
  • [MeSH-major] Biopsy, Needle / methods. Breast / pathology. Breast Neoplasms / surgery

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  • (PMID = 20651381.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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48. Tseng HS, Chen YL, Chen ST, Wu YC, Kuo SJ, Chen LS, Wu HK, Chen DR: The management of papillary lesion of the breast by core needle biopsy. Eur J Surg Oncol; 2009 Jan;35(1):21-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The management of papillary lesion of the breast by core needle biopsy.
  • BACKGROUND: The purpose of this study was to determine the accuracy of core needle biopsy (CNB) diagnoses of papillary breast lesions, and to identify the risk factors and histologic features, compared with excisional biopsy (EB).
  • Surgical correlation was available for 35 cases, 2 cases were loss follow-up and 4 cases diagnosed as papilloma by core needle biopsy were followed up with imaging for at least 24 months.
  • RESULTS: The pathologic diagnoses for the 35 papillary lesions obtained at core biopsy were benign in 24 cases, atypical in 7, and malignant in 4.
  • CONCLUSION: All papillary lesions of the breast diagnosed by CNB should be excised because a substantial number of lesions were upgraded of diagnoses at excision.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Carcinoma, Papillary / pathology
  • [MeSH-minor] Adult. Aged. Breast / pathology. Breast / surgery. Female. Humans. Middle Aged. Retrospective Studies. Ultrasonography, Interventional. Ultrasonography, Mammary

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  • (PMID = 18640002.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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49. Putti TC, Pinder SE, Elston CW, Lee AH, Ellis IO: Breast pathology practice: most common problems in a consultation service. Histopathology; 2005 Nov;47(5):445-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast pathology practice: most common problems in a consultation service.
  • Considerable progress has been made in understanding breast lesions utilizing molecular methods, but conventional morphology, simple immunohistochemical stains and common sense still prevail in diagnosing the vast majority of breast disease.
  • The focus of this review is to identify the most common breast lesions sent to our consultation practice, and to reiterate salient diagnostic features, differential diagnoses and common pitfalls in identifying these lesions.
  • Separation of epithelial proliferative lesions and differentiation between usual epithelial hyperplasia (UEH) and atypical ductal hyperplasia (ADH) are the most common problems encountered in our Consultation practice.
  • [MeSH-major] Breast Diseases / diagnosis. Mammary Glands, Human / pathology. Referral and Consultation
  • [MeSH-minor] Adult. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma in Situ / diagnosis. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Fibrosis / diagnosis. Fibrosis / pathology. Humans. Hyperplasia / diagnosis. Hyperplasia / pathology. Middle Aged. Neoplasms, Fibroepithelial / diagnosis. Neoplasms, Fibroepithelial / pathology. Papilloma / diagnosis. Papilloma / pathology

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  • (PMID = 16241992.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 43
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50. Carder PJ, Khan T, Burrows P, Sharma N: Large volume "mammotome" biopsy may reduce the need for diagnostic surgery in papillary lesions of the breast. J Clin Pathol; 2008 Aug;61(8):928-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large volume "mammotome" biopsy may reduce the need for diagnostic surgery in papillary lesions of the breast.
  • BACKGROUND: There is currently debate as to whether all papillary lesions diagnosed on breast needle core biopsy (BNCB) require surgical excision.
  • Four cases included an atypical ductal epithelial proliferation (three B4, one B3).
  • In two cases the mammotome biopsy was either atypical or malignant, prompting surgery; the biopsy changes deriving from areas of ductal carcinoma in situ arising in the context of multiple intraduct papillomas and both were distinctive mammographically in presenting with large areas of segmental calcification.
  • This has important implications for symptomatic and breast screening services.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Papillary / pathology
  • [MeSH-minor] Biopsy / methods. Calcinosis / radiography. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Mammography. Papilloma / pathology. Ultrasonography, Mammary

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  • (PMID = 18495791.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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51. Bernik SF, Troob S, Ying BL, Simpson SA, Axelrod DM, Siegel B, Moncrief RM, Mills C, Aziz M: Papillary lesions of the breast diagnosed by core needle biopsy: 71 cases with surgical follow-up. Am J Surg; 2009 Apr;197(4):473-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary lesions of the breast diagnosed by core needle biopsy: 71 cases with surgical follow-up.
  • BACKGROUND: Papillary breast lesions comprise a spectrum of histopathologic diagnoses ranging from benign papillomas to papillary carcinomas.
  • The current study assessed the adequacy of CNB in evaluating papillary breast lesions.
  • RESULTS: Of the 71 papillary lesions excised, 8 were malignant, 16 were atypical, and 47 were benign at the time of CNB.
  • Of the 13 atypical papillary lesions on CNB, 7 lesions (54%) were associated with malignancy upon excision.
  • Therefore, surgical excision should be performed to avoid missing a malignancy and to allow for accurate breast cancer risk assessment that can impact survival and decisions regarding chemoprevention.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Papillary / pathology. Papilloma / pathology

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  • (PMID = 18723154.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Catalano O, Raso MM, D'Aiuto M, Illiano LA, Saturnino PP, Siani A: Additional role of colour Doppler ultrasound imaging in intracystic breast tumours. Radiol Med; 2009 Mar;114(2):253-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Additional role of colour Doppler ultrasound imaging in intracystic breast tumours.
  • PURPOSE: Cystic breast lesions with a nonsimple appearance, either complicated or complex, pose unique diagnostic difficulties, in part owing to their potentially malignant nature.
  • MATERIALS AND METHODS: Over a 1-year period, we prospectively evaluated 45 women with atypical breast cysts of type IV, V or VI according to the Chang classification.
  • Among the 22 tumoural lesions, there were eight papillomas, one atypical ductal hyperplasia and 13 carcinomas.
  • The atypical ductal hyperplasia showed a single parietal nodule.
  • Cystic content appeared clear in six papillomas and in the case of atypical ductal hyperplasia, whereas it exhibited fine echoes in two papillomas.
  • Colour Doppler imaging showed lack of flow in four papillomas and subtle flow in the remaining four papillomas and in the atypical ductal hyperplasia.
  • CONCLUSIONS: Intracystic breast tumours exhibit distinctive morphostructural and colour Doppler features that allow effective differentiation from nontumoural cysts.
  • [MeSH-major] Breast Cyst / diagnostic imaging. Ultrasonography, Doppler, Color. Ultrasonography, Mammary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / diagnostic imaging. Carcinoma / diagnostic imaging. Diagnosis, Differential. Female. Humans. Hyperplasia / diagnostic imaging. Middle Aged. Papilloma / diagnostic imaging. Prospective Studies. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 19082789.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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53. Cîmpean AM, Raica M, Nariţa D: Diagnostic significance of the immunoexpression of CD34 and smooth muscle cell actin in benign and malignant tumors of the breast. Rom J Morphol Embryol; 2005;46(2):123-9
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  • [Title] Diagnostic significance of the immunoexpression of CD34 and smooth muscle cell actin in benign and malignant tumors of the breast.
  • METHODS: Our study included 112 female patients with suspect breast masses obtained by surgery or biopsy.
  • RESULTS: We have found normal breast tissue, sclerosing adenosis, fibroadenomas, fibrocystic diseases, phyllodes tumor, DCIS, ductal invasive, lobular, squamous, medullary, mucinous, and papillary carcinomas.
  • We also found apocrine metaplasia, florid ductal hyperplasia, atypical hyperplasia, papilloma and LCIS associated with the malignant tumors.
  • All the normal breast tissues and most of benign lesions were positive for CD34 and negative for SMA.
  • [MeSH-major] Actins / analysis. Antigens, CD34 / analysis. Breast Neoplasms / pathology. Muscle, Smooth / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Biopsy. Carcinoma, Ductal / pathology. Female. Fibrocystic Breast Disease / pathology. Humans. Middle Aged. Neoplasm Invasiveness. Smad Proteins / analysis

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  • (PMID = 16286998.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Smad Proteins
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54. Antuofermo E, Miller MA, Pirino S, Xie J, Badve S, Mohammed SI: Spontaneous mammary intraepithelial lesions in dogs--a model of breast cancer. Cancer Epidemiol Biomarkers Prev; 2007 Nov;16(11):2247-56
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  • [Title] Spontaneous mammary intraepithelial lesions in dogs--a model of breast cancer.
  • IELs, found in specimens from 60 dogs, were categorized as adenosis, sclerosing adenosis, intraductal papilloma, sclerosing papilloma, ductal hyperplasia, atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS; high, intermediate, and low grade).
  • Canine mammary IELs were strikingly similar to those of the human breast.
  • The frequency of IELs in the dog, their association with spontaneous mammary cancer, their pattern of ER-alpha and HER-2 expression, and their histologic resemblance to human IELs may make the dog an ideal model to study human ER-negative (both HER-2 positive and negative) breast cancer progression as well as prevention and treatment.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma in Situ / veterinary. Dog Diseases / pathology. Mammary Neoplasms, Animal / pathology

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  • [CommentIn] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2181-3 [17982116.001]
  • (PMID = 17982119.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Ki-67 Antigen; 0 / Receptors, Progesterone; EC 2.7.10.1 / Receptor, ErbB-2
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55. Ballesio L, Maggi C, Savelli S, Angeletti M, De Felice C, Meggiorini ML, Manganaro L, Porfiri LM: Role of breast magnetic resonance imaging (MRI) in patients with unilateral nipple discharge: preliminary study. Radiol Med; 2008 Mar;113(2):249-64
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  • [Title] Role of breast magnetic resonance imaging (MRI) in patients with unilateral nipple discharge: preliminary study.
  • MATERIALS AND METHODS: Forty-four patients with bloody or serosanguineous nipple discharge and negative mammographic findings (35/44 cases) underwent MRI for evaluation of breast ducts.
  • RESULTS: MRI identified 25 enhancing lesions Breast Imaging Reporting and Data Systems (BI-RADS) 3 or 4) and confirmed the galactographic findings (ductal ectasia, intraluminal filling defects).
  • Five papillomatoses appeared as patchy, homogeneous enhancing areas, 15 intraductal papillomas as areas with well-defined margins and type II time-intensity curves, and two atypical ductal hyperplasias as diffuse nodular enhancement.
  • CONCLUSIONS: Breast MRI can be considered a valuable examination in the diagnosis of suspected ductal disease and an alternative to galactography when the latter cannot be used.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / diagnosis. Magnetic Resonance Imaging. Nipples / secretion
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Breast Diseases / diagnosis. Breast Neoplasms, Male / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Female. Humans. Male. Mammography. Middle Aged. Papilloma, Intraductal / diagnosis. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18386126.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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56. Tse GM, Ma TK, Lui PC, Ng DC, Yu AM, Vong JS, Niu Y, Chaiwun B, Lam WW, Tan PH: Fine needle aspiration cytology of papillary lesions of the breast: how accurate is the diagnosis? J Clin Pathol; 2008 Aug;61(8):945-9
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  • [Title] Fine needle aspiration cytology of papillary lesions of the breast: how accurate is the diagnosis?
  • RESULTS: The overall diagnostic accuracy was 59%, atypical rate was 24%, and the error (combined false positive and negative) rate was 17%.
  • There was no demonstrable quantitative difference between papilloma and papillary carcinoma for all these parameters.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Papillary / pathology. Papilloma / pathology

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  • (PMID = 18552172.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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57. Li JL, Wang ZL, Su L, Liu XJ, Tang J: Breast lesions with ultrasound imaging-histologic discordance at 16-gauge core needle biopsy: can re-biopsy with 10-gauge vacuum-assisted system get definitive diagnosis? Breast; 2010 Dec;19(6):446-9
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  • [Title] Breast lesions with ultrasound imaging-histologic discordance at 16-gauge core needle biopsy: can re-biopsy with 10-gauge vacuum-assisted system get definitive diagnosis?
  • The aim of this study was to evaluate if re-biopsy with 10-gauge vacuum-assisted biopsy (VAB) could get definitive diagnosis for breast lesions with ultrasound (US) imaging-histologic discordance at 16-gauge core needle biopsy (CNB).
  • In them, one case upgraded from adenosis to ductal carcinoma in situ (DCIS); one case upgraded from adenosis to infiltrating ductal carcinoma (IDC); one case upgraded from atypical ductal hyperplasia to IDC; two cases upgraded from intraductal papilloma to DCIS; and one case upgraded from sclerosing adenosis to invasive lobular carcinoma (ILC).
  • Re-biopsy could improve diagnostic accuracy in patients with breast lesions showing imaging-histologic discordance during CNB, and 10-gauge VAB was a valuable method to deal with re-biopsy.
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Lobular / pathology
  • [MeSH-minor] Adult. Aged. Breast / pathology. Diagnosis, Differential. Female. Humans. Hyperplasia / pathology. Middle Aged. Predictive Value of Tests

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20869243.001).
  • [ISSN] 1532-3080
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
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58. Kinkor Z, Skálová A, Ondrias F: [Intraductal papillary proliferation of brest. Actual review and clinicopathological corelation]. Ceska Gynekol; 2006 Jan;71(1):61-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Complex summary addressing current view of the intraductal papillary lesions of breast, especially focused on morphology, exact terminology and clinicopathological aspects of effective therapy.
  • METHODS: Summarized recent data, diagnostic principals and clinicopathological recommendations of papillary breast lesions created comprehensive guide for daily diagnostic and therapeutic practice.
  • RESULTS: The group of papillary tumors of the breast includes various lesions with different biologic potential.
  • The reason is frequent occurrence of atypical ductal hyperplasia/intraductal (in situ) carcinoma in the adjacent tissue.
  • Atypical papilloma is still very controversial issue and it essentially means situation when atypical ductal hyperplasia/conventional ductal in situ carcinoma arises in preexisting papillomas or extends to it from neighborhood.
  • Finding of benign papilloma in core biopsy remains unsolved question yet.

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  • (PMID = 16465918.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 9
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59. Tschirch FT, Kubik-Huch RA, Knüsel PR, Komminoth P, Hohl MK, Otto RC: [Evaluation of bloody nipple discharge]. Praxis (Bern 1994); 2005 Mar 9;94(10):387-90
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  • Finally galactography supposed the diagnosis of an intraductal papilloma which was confirmed by surgery.
  • Histopathologically an eight millimeter measuring intraductal papilloma with atypical ductal hyperplasia with signs of a carcinoma in situ was seen.
  • [MeSH-major] Blood. Breast Neoplasms / diagnosis. Calcinosis / diagnosis. Carcinoma in Situ / diagnosis. Mammary Glands, Human. Neoplasms, Multiple Primary / diagnosis. Nipples / secretion. Papilloma, Intraductal / diagnosis
  • [MeSH-minor] Breast Cyst / diagnosis. Carcinoma, Ductal / diagnosis. Carcinoma, Ductal / pathology. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Female. Fibroadenoma / diagnosis. Humans. Hyperplasia. Mammography. Middle Aged. Ultrasonography, Mammary

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  • (PMID = 15795963.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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60. Kapenhas-Valdes E, Feldman SM, Cohen JM, Boolbol SK: Mammary ductoscopy for evaluation of nipple discharge. Ann Surg Oncol; 2008 Oct;15(10):2720-7
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  • BACKGROUND: Most breast cancers originate in the ductal epithelium with normal cells progressing to atypia and finally to carcinoma.
  • Forty-two patients were diagnosed with papilloma/papillomatosis, six patients were diagnosed with atypical papilloma/atypical ductal hyperplasia/atypical lobular hyperplasia, and six patients were diagnosed with cancer.
  • Of the six patients diagnosed with cancer, 67% had normal breast imaging, and other than nipple discharge, 67% had normal breast examinations.
  • Although the most common cause of nipple discharge is an intraductal papilloma, nipple discharge can be the presenting symptom for cancer.
  • Our experience revealed a papilloma rate of 45% (42 of 93), cancer rate of 6.5% (6 of 93), and an atypia rate of 6.5% (6 of 93) among the patients with nipple discharge.
  • [MeSH-major] Breast Neoplasms / diagnosis. Endoscopy. Mammary Glands, Human / pathology. Nipples / secretion
  • [MeSH-minor] Adult. Aged. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Exudates and Transudates. Female. Humans. Middle Aged. Papilloma, Intraductal / diagnosis. Predictive Value of Tests. Prospective Studies

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  • (PMID = 18685898.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Ling H, Liu GY, Lu JS, Love S, Zhang JX, Xu XL, Xu WP, Shen KW, Shen ZZ, Shao ZM: Fiberoptic ductoscopy-guided intraductal biopsy improve the diagnosis of nipple discharge. Breast J; 2009 Mar-Apr;15(2):168-75
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  • Twenty-seven solitary papillomas, 12 multiple intraductal papilloma, five ductal hyperplasia, three ductal carcinoma in situ, and one invasive ductal carcinoma were diagnosed.
  • Compared with conventional microdochectomy, FDS-guided intraductal biopsy can significantly increase the detection rate of solitary papilloma (40.7% versus 92.6%, p < 0.05).
  • Since it would underestimate all multiple intraductal papilloma and some (50%) cancer, microdochectomy is inevitable if biopsies show atypical ductal hyperplasia.
  • [MeSH-major] Breast Diseases / pathology. Breast Neoplasms / pathology. Fiber Optic Technology. Nipples / pathology
  • [MeSH-minor] Biopsy / methods. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / surgery. Female. Humans. Hyperplasia / pathology. Papilloma / pathology. Papilloma / surgery

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  • (PMID = 19292803.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N02-CO-41101
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Kamali S, Bender O, Aydin MT, Yuney E, Kamali G: Ductoscopy in the evaluation and management of nipple discharge. Ann Surg Oncol; 2010 Mar;17(3):778-83
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  • BACKGROUND: Nipple discharge is a relatively common complaint among patients visiting specialized outpatient clinics for disease of the breast.
  • Of these, 39 patients were found to have intraductal solitary papilloma of which 24 were excised ductoscopically.
  • Ductoscopy revealed atypical ductal hyperplasia in 3 patients, ductal carcinoma in situ in 6 patients, and invasive carcinoma in 3 patients; all patients underwent surgery.
  • CONCLUSIONS: We believe that, as the technology quickly improves, ductoscopy will become more widely accepted and applied for breast disorders, not only as a diagnostic tool but also as a privileged therapeutic option for certain pathologies.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Endoscopy. Mammary Glands, Human / pathology. Nipples / secretion. Papilloma, Intraductal / diagnosis

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  • (PMID = 20012502.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Sebag P, Tourasse C, Rouyer N, Lebas P, Dénier JF, Michenet P: [Value of vacuum assisted biopsies under sonography guidance: results from a multicentric study of 650 lesions]. J Radiol; 2006 Jan;87(1):29-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 5 cases vacuum biopsy underestimated the pathology with regard to surgery: 2 cases of atypical duct hyperplasia (HCA) were in situ ductal carcinoma (DCIS) at surgery and 3 cases of DCIS were infiltrative ductal carcinoma (DCI) at surgery.
  • The ability to collect a larger volume of tissue overcomes the targeting issues on small lesions and avoids underestimation of heterogeneous and larger abnormalities and some specific at-risk lesions such as papilloma.
  • [MeSH-major] Biopsy, Needle / methods. Breast / pathology. Ultrasonography, Interventional. Ultrasonography, Mammary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms / pathology. Breast Neoplasms / ultrasonography. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Fibroadenoma / pathology. Follow-Up Studies. Humans. Hyperplasia. Middle Aged. Minimally Invasive Surgical Procedures. Papilloma / pathology. Phyllodes Tumor / pathology. Retrospective Studies. Sensitivity and Specificity. Vacuum

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  • (PMID = 16415777.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
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64. Rose C, Bojahr B, Grunwald S, Frese H, Jäger B, Ohlinger R: Ductoscopy-based descriptors of intraductal lesions and their histopathologic correlates. Onkologie; 2010;33(6):307-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • For all breast lesions, the factors lesion type, number of lesions, lesion color, surface characteristics, and presence of blood or atypical vessels were reported.
  • RESULTS: Among the ductoscopic criteria, a fissured surface, hemorrhage or atypical vessels, and a polypoid appearance were important predictors for malignant lesions.
  • In contrast, a smooth surface, the absence of hemorrhage and atypical vessels and a level appearance of the lesions predicted benign lesions.
  • CONCLUSIONS: For predicting the benign versus malignant character of ductoscopic lesions, the following criteria should be used: presence or absence of blood and atypical vessels, surface type, and level versus polypoid appearance.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Endoscopy. Mammary Glands, Human / pathology. Neoplasms, Multiple Primary / pathology. Papilloma, Intraductal / pathology
  • [MeSH-minor] Breast / pathology. Breast Diseases / pathology. Diagnosis, Differential. Female. Fibroadenoma / pathology. Fibroadenoma / surgery. Galactorrhea / pathology. Humans. Odds Ratio. Prognosis. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 20523094.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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65. Kil WH, Cho EY, Kim JH, Nam SJ, Yang JH: Is surgical excision necessary in benign papillary lesions initially diagnosed at core biopsy? Breast; 2008 Jun;17(3):258-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The objective of this study is to propose management guidelines for benign papillary breast lesions initially diagnosed at core biopsy.
  • Three of the eight atypical papillomas initially diagnosed at core needle biopsy were confirmed as papillary cancer in final pathology, giving a false-negative rate of 37.5%.
  • It is concluded that atypical papillomas at initial core biopsy or large, clinically peripherally located papillomas (>1.5 cm) need additional surgical excision.
  • [MeSH-major] Breast Neoplasms / surgery. Carcinoma, Papillary / surgery. Papilloma

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  • (PMID = 18054232.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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66. Yang GZ, Li J, Ding HY: [Nipple adenoma: report of 18 cases with review of literatures]. Zhonghua Bing Li Xue Za Zhi; 2009 Sep;38(9):614-6
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  • OBJECTIVE: To investigate the clinicopathological and immunohistochemical features, diagnosis and differential diagnosis of nipple adenoma of the breast.
  • RESULTS: The neoplasms were localized at nipples or under the areola of breast, adherent to the epidermis, mainly composed of dilated ducts in a tubular appearance associated with fibrotic matrix.
  • CONCLUSIONS: Nipple adenoma is an infrequent type of benign breast neoplasm, presenting as sclerosing papilloma, papillomatosis or florid sclerosing adenosis.
  • It is easily confused with atypical ductal hyperplasia/low grade ductal carcinoma in situ, invasive ductal carcinoma or low grade adenosquamous carcinoma.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Nipples / pathology
  • [MeSH-minor] Adult. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma, Adenosquamous / metabolism. Carcinoma, Adenosquamous / pathology. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Diagnosis, Differential. Female. Humans. Keratin-5 / metabolism. Keratins / metabolism. Middle Aged

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  • (PMID = 20079190.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CK-34 beta E12; 0 / Keratin-5; 68238-35-7 / Keratins
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67. Liu GY, Lu JS, Shen KW, Wu J, Chen CM, Hu Z, Shen ZZ, Zhang TQ, Shao ZM: Fiberoptic ductoscopy combined with cytology testing in the patients of spontaneous nipple discharge. Breast Cancer Res Treat; 2008 Mar;108(2):271-7
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  • Among 437 (40.0%) of the FDS-positive breasts, we revealed 49 (11.2%) breast carcinomas, 228 (52.2%) central papillomas, and 5 (1.1%) cases of atypical ductal hyperplasia.
  • [MeSH-major] Breast Diseases / pathology. Breast Neoplasms / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Cytological Techniques. Endoscopy / methods. Nipples / secretion. Papilloma / pathology. Precancerous Conditions / pathology

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  • (PMID = 17473979.001).
  • [ISSN] 0167-6806
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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68. Plantade R, Hammou JC, Gerard F, Chanalet I, Aubanel D, David-Bureau M, Scotto A, Fighiera M, Gueret S, Lo Monaco L: [Ultrasound-guided vacuum-assisted biopsy: review of 382 cases]. J Radiol; 2005 Sep;86(9 Pt 1):1003-15
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  • PURPOSE: To evaluate the use of US-guided vacuum biopsy for diagnosis and treatment of probably benign breast masses.
  • Open surgical biopsy was carried out for 35 patients on the basis of incomplete removal (3 cases) or histologic findings (8 invasive carcinomas, 7 ductal carcinoma in situ, 3 atypical ductal hyperplasia, 1 fibrocystic changes with atypia and 11 papillomas).
  • [MeSH-major] Biopsy, Needle / methods. Breast Neoplasms / pathology. Ultrasonography, Interventional
  • [MeSH-minor] Adolescent. Adult. Aged. Breast / pathology. Carcinoma / pathology. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / pathology. Female. Fibroadenoma / pathology. Follow-Up Studies. Humans. Middle Aged. Papilloma / pathology. Retrospective Studies. Vacuum

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  • (PMID = 16224340.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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69. Grunwald S, Bojahr B, Schwesinger G, Schimming A, Kohler G, Schulz K, Ohlinger R: Mammary ductoscopy for the evaluation of nipple discharge and comparison with standard diagnostic techniques. J Minim Invasive Gynecol; 2006 Sep-Oct;13(5):418-23
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  • STUDY OBJECTIVE: To describe performance of breast duct endoscopy and compare the method with conventional diagnostic techniques.
  • SETTING: Interdisciplinary Breast Unit of a university hospital.
  • Breast ultrasound scanning showed abnormalities, classified as BI-RADS-III equivalent lesions in all cases.
  • Nipple smear showed in 69.2% a normal cytology and in most cases revealed a papilloma later (n=8/9).
  • Two galactography results were unremarkable, and open biopsy demonstrated 1 atypical ductal hyperplasia and papilloma.
  • In 17 cases open biopsy followed ductoscopy, and 1 ductal carcinoma in situ (DCIS), 3 atypical ductal hyperplasia (ADH), 1 ductal hyperplasia without atypias, and 12 ductal papillomas were found.
  • CONCLUSION: Compared to nipple smear, the diagnostic value of ductoscopy in this study is superior but marginally inferior to galactography and highly specialized breast ultrasound scanning.
  • [MeSH-major] Breast Diseases / diagnosis. Endoscopy / methods. Mammary Glands, Human. Nipples / secretion

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  • (PMID = 16962525.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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70. Denewer A, El-Etribi K, Nada N, El-Metwally M: The role and limitations of mammary ductoscope in management of pathologic nipple discharge. Breast J; 2008 Sep-Oct;14(5):442-9
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  • Mammary ductoscope allows visualization of the breast ductal wall and sampling of the abnormal area for diagnostic purposes.
  • Between November 2005 and December 2006 a total of 54 women, with spontaneous persistent nonlactational unilateral uniductal nipple discharge of no palpable lesions and negative breast sono-mammography, were included in the study for morphologic assessment of ductal epithelium, ductal lavage and ductoscopically guided procedures as punch biopsy and ductoscopically guided microdochectomy.
  • Ductal thickening by the ductoscope (11 cases) revealed to be hyperplasia on pathology (five cases), papilloma (two cases), atypical ductal hyperplasia (two cases), ductal carcinoma in situ (one case), and invasive breast carcinoma (one case).
  • [MeSH-major] Breast Neoplasms / pathology. Endoscopy / methods. Exudates and Transudates / cytology. Nipples / pathology. Nipples / secretion
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Breast Diseases / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / ultrasonography. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / ultrasonography. Carcinoma, Lobular / pathology. Carcinoma, Lobular / ultrasonography. Cohort Studies. Diagnosis, Differential. Female. Fiber Optic Technology / methods. Humans. Middle Aged. Probability. Risk Assessment. Sensitivity and Specificity. Ultrasonography, Mammary

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  • (PMID = 18673337.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Vazmitel M, Spagnolo DV, Nemcova J, Michal M, Kazakov DV: Hidradenoma papilliferum with a ductal carcinoma in situ component: case report and review of the literature. Am J Dermatopathol; 2008 Aug;30(4):392-4
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  • Hidradenoma papilliferum (HP) is a benign cutaneous adnexal neoplasm occurring mainly in the anogenital region of adult women and has features analogous to intraductal papilloma of the breast.
  • We present a new case of HP which, in addition to the typical appearance of HP, contained a focus of ductal carcinoma in situ that appeared as enlarged pleomorphic epithelial cells having a "blastic" appearance, exhibiting atypical mitotic figures and surrounded by myoepithelial cells.

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  • (PMID = 18645314.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. El-Daly H, Gudi M: Evaluation of nipple discharge cytology and diagnostic value of red blood cells in cases with negative cytology: a cytohistologic correlation. Acta Cytol; 2010 Jul-Aug;54(4):560-2
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  • Thirty of these cases had subsequent biopsy and showed: 9 benign cases, 3 cases with atypical papilloma and 3 cases with a malignant diagnosis (in situ and/or invasive ductal carcinoma).
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Erythrocytes / pathology. Exudates and Transudates / cytology. Nipples / pathology

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  • (PMID = 20715656.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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76. Handschin AE, Bietry D, Hüsler R, Banic A, Constantinescu M: Surgical management of gynecomastia--a 10-year analysis. World J Surg; 2008 Jan;32(1):38-44

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  • BACKGROUND: Gynecomastia is defined as the benign enlargement of the male breast.
  • Techniques included subcutaneous mastectomy alone or with additional hand-assisted liposuction, isolated liposuction, and formal breast reduction.
  • Atypical histological findings were found in 3% of the patients (spindle-cell hemangioendothelioma, papilloma).
  • Histological tissue analysis should be routinely performed in all true gynecomastia corrections, because histological results may reveal atypical cellular pathology.

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  • (PMID = 18026791.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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