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1. Thai D, Dyer JE, Jacob P, Haller CA: Clinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers. Clin Pharmacol Ther; 2007 Feb;81(2):178-84
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  • Some subjects exhibited slow oral clearance of BD, which tended to correlate with a variant haplotype of the alcohol dehydrogenase gene ADH-IB G143A.
  • BD was extensively converted to GHB after oral administration, but significant inter-individual variability in the rate of metabolism, possibly related to variants in ADH-IB, was observed.

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  • (PMID = 17192771.001).
  • [ISSN] 0009-9236
  • [Journal-full-title] Clinical pharmacology and therapeutics
  • [ISO-abbreviation] Clin. Pharmacol. Ther.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA 14935; United States / NIDA NIH HHS / DA / DA12393; United States / NCRR NIH HHS / RR / M01RR00083-41; United States / NIGMS NIH HHS / GM / T32 GM007546-28
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Butylene Glycols; 7G33012534 / Sodium Oxybate; 7XOO2LE6G3 / 1,4-butanediol; EC 1.1.1.1 / Alcohol Dehydrogenase; S88TT14065 / Oxygen
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2. Vallet A, Santarelli X, Lonvaud-Funel A, de Revel G, Cabanne C: Purification of an alcohol dehydrogenase involved in the conversion of methional to methionol in Oenococcus oeni IOEB 8406. Appl Microbiol Biotechnol; 2009 Feb;82(1):87-94
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  • Alcohol dehydrogenase (ADH) activity was found to be present in the soluble fraction of O. oeni IOEB 8406.
  • An NAD(P)H-dependent ADH involved in the reduction of methional was then purified to homogeneity.
  • Despite the great importance of ADH activities in wine flavor modification, this is the first report of the purification of an ADH isolated from O. oeni.
  • The purified ADH does not seem to be involved in the modification of buttery and lactic notes or to be involved in the specific formation of volatile alcohols during MLF.
  • The function of the purified ADH remains unclear, although the role of the sulfur atom in methional molecules in the interaction between enzyme and substrate was evidenced.

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  • (PMID = 18850096.001).
  • [ISSN] 1432-0614
  • [Journal-full-title] Applied microbiology and biotechnology
  • [ISO-abbreviation] Appl. Microbiol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Bacterial Proteins; 0AAO8V0F1R / methional; AE28F7PNPL / Methionine; EC 1.1.1.1 / Alcohol Dehydrogenase
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3. Cho YH, Gitelman S, Rosenthal S, Ambler G: Long-term outcomes in a family with nephrogenic syndrome of inappropriate antidiuresis. Int J Pediatr Endocrinol; 2009;2009:431527
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  • The proband and one maternal uncle presented in their infancy with severe recurrent hyponatremia, and clinical pictures consistent with the syndrome of inappropriate antidiuretic hormone (SIADH) in the absence of an elevated ADH level.

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  • (PMID = 20148077.001).
  • [ISSN] 1687-9856
  • [Journal-full-title] International journal of pediatric endocrinology
  • [ISO-abbreviation] Int J Pediatr Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2817859
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4. Tourasse C, Sebag P, Dénier J, Rouyer N, Donné C: [Value of stereotactic breast core biopsy in patients with atypical ductal hyperplasia]. J Radiol; 2008 Jan;89(1 Pt 1):40-6
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  • [Title] [Value of stereotactic breast core biopsy in patients with atypical ductal hyperplasia].
  • [Transliterated title] Valeur des macrobiopsies mammaires sous guidage stéréotaxique en cas de découverte d'une hyperplasie canalaire atypique.
  • RESULTS: The rate of under-diagnosis was 5.9% for ductal carcinoma in-situ (DCIS) and 12.5% for atypical ductal hyperplasia (ADH).
  • Most cases of under-diagnosis involved clusters larger than 20 mm in diameter where the percentage of excision decreased from 98% (clusters<10 mm) to 9%.
  • ADH was never under-diagnosed when 3 or less foci were present.
  • The risk of under-diagnosis for DCIS increased when the number of biopsies containing DCIS was superior to 50% and if the grade was high.
  • CONCLUSION: The presence of ADH on biopsy specimens requires surgical biopsy, but optimal core biopsies with cluster removal and histological analysis by an experienced observer allows identification of low risk patients that could undergo close follow-up.
  • [MeSH-major] Biopsy / methods. Breast Neoplasms / pathology. Calcinosis / pathology. Mammary Glands, Human / pathology. Stereotaxic Techniques
  • [MeSH-minor] Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Carcinoma, Lobular / pathology. Carcinoma, Lobular / surgery. Diagnosis, Differential. Female. Humans. Hyperplasia. Mass Screening. Retrospective Studies. Risk Factors

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  • (PMID = 18288025.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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5. Perkins RM, Yuan CM, Welch PG: Dipsogenic diabetes insipidus: report of a novel treatment strategy and literature review. Clin Exp Nephrol; 2006 Mar;10(1):63-7
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  • Results of extensive water testing revealed intact urinary concentrating and diluting capacity, physiologic though blunted antidiuretic hormone (ADH) release, and an abnormally low thirst threshold, consistent with the diagnosis of dipsogenic diabetes insipidus.
  • Dipsogenic diabetes insipidus is an uncommonly (and not universally) recognized disorder, requiring monitored testing in order to distinguish it from incomplete forms of central diabetes insipidus.

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  • (PMID = 16544179.001).
  • [ISSN] 1342-1751
  • [Journal-full-title] Clinical and experimental nephrology
  • [ISO-abbreviation] Clin. Exp. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Fukuda T, Yokoyama J, Nakamura T, Song IJ, Ito T, Ochiai T, Kanno A, Kameya T, Maki M: Molecular phylogeny and evolution of alcohol dehydrogenase (Adh) genes in legumes. BMC Plant Biol; 2005;5:6
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  • [Title] Molecular phylogeny and evolution of alcohol dehydrogenase (Adh) genes in legumes.
  • The aim of our study is to isolate the alcohol dehydrogenase (Adh) genes in two distantly related legumes, and use these sequences to examine the molecular evolutionary history of this nuclear gene.
  • RESULTS: We isolated the expressed Adh genes from two species of legumes, Sophora flavescens Ait. and Wisteria floribunda DC., by a RT-PCR based approach and found a new Adh locus in addition to homologues of the Adh genes found previously in legumes.
  • To examine the evolution of these genes, we compared the species and gene trees and found gene duplication of the Adh loci in the legumes occurred as an ancient event.
  • CONCLUSION: This is the first report revealing that some legume species have at least two Adh gene loci belonging to separate clades.

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  • (PMID = 15836788.001).
  • [ISSN] 1471-2229
  • [Journal-full-title] BMC plant biology
  • [ISO-abbreviation] BMC Plant Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB191334/ AB191335/ AB191336/ AB191337/ AB191338/ AB191339
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ PMC1112602
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7. López-Medina A, Cintora E, Múgica B, Operé E, Vela AC, Ibañez T: Radial scars diagnosed at stereotactic core-needle biopsy: surgical biopsy findings. Eur Radiol; 2006 Aug;16(8):1803-10
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  • Of these 43 lesions, histopathological analysis of the surgical specimen yielded RS in 27 (63%), RS plus atypical ductal hyperplasia (ADH) in 8 (18%), RS plus carcinoma in five (12%), and only carcinoma in three (7%).
  • Carcinomas underestimated at SCNB (n=8) were two in situ carcinomas, two invasive ductal carcinomas not otherwise specified, and four tubular carcinomas.
  • The results suggest that the diagnosis of RS at 14-gauge SCNB of mammographically detected lesions is an indication for surgical biopsy because of the high prevalence of carcinoma in these lesions.
  • [MeSH-major] Biopsy. Breast Diseases / pathology
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Diagnosis, Differential. Female. Humans. Mammography. Middle Aged. Radiography, Interventional. Retrospective Studies. Stereotaxic Techniques. Ultrasonography, Interventional. Ultrasonography, Mammary

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  • (PMID = 16708220.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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8. Suzuki S, Goto M, Okamoto T, Tomita I, Murayama A, Sawa M, Noguchi Y, Hoshikawa Y, Shimizu A: [A case of small cell carcinoma of the esophagus with SIADH]. Gan To Kagaku Ryoho; 2010 Jan;37(1):123-6
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  • Under diagnosis of small cell carcinoma of the esophagus at Stage IVa, neoadjuvant chemotherapy with FP (5-FU+CDDP) was given.
  • Pathological examination with IHC demonstrated positive staining for CD56, NSE and synaptophysin but negative for ADH.
  • [MeSH-major] Carcinoma, Small Cell / complications. Esophageal Neoplasms / complications. Inappropriate ADH Syndrome / etiology

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  • (PMID = 20087045.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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9. Hameed O, Ghali VS, Tartter PI, Mizrachi H: Immunohistochemical staining for cyclin D1 and Ki-67 aids in the stratification of atypical ductal hyperplasia diagnosed on breast core biopsy. Am J Clin Pathol; 2005 Dec;124(6):862-72
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  • [Title] Immunohistochemical staining for cyclin D1 and Ki-67 aids in the stratification of atypical ductal hyperplasia diagnosed on breast core biopsy.
  • A diagnosis of atypical ductal hyperplasia (ADH) after breast core biopsy usually is followed by an excisional biopsy to exclude the presence of a more significant lesion.
  • To determine whether the immunohistochemical expression of cyclin D1 (CyD1) and Ki-67 can aid in case stratification for the likelihood of finding ductal carcinoma in situ (DCIS) on subsequent excision, we immunohistochemically stained 21 consecutive ADH cases diagnosed by core biopsy, and proliferation indices (PIs) were calculated for each case.
  • The number of cells with CCND1 amplification was higher in cases with DCIS or ADH on subsequent excision.
  • Immunostaining for CyD1 and Ki-67 might help stratify cases of ADH on core biopsy and identify patients unlikely to have DCIS found on excision.
  • [MeSH-minor] Aged. Breast Neoplasms / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Female. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Immunohistochemistry. In Situ Hybridization, Fluorescence. Middle Aged

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  • (PMID = 16416735.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 136601-57-5 / Cyclin D1
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10. Ogueta M, Cibik O, Eltrop R, Schneider A, Scholz H: The influence of Adh function on ethanol preference and tolerance in adult Drosophila melanogaster. Chem Senses; 2010 Nov;35(9):813-22
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  • [Title] The influence of Adh function on ethanol preference and tolerance in adult Drosophila melanogaster.
  • We also investigated whether Drosophila preference, sensitivity and tolerance to ethanol was related to the activity of alcohol dehydrogenase (Adh), the primary ethanol-metabolizing enzyme in D. melanogaster.
  • Impaired Adh function reduced ethanol preference in both D. melanogaster and a related species, D. sechellia.
  • Adh-impaired flies also displayed reduced aversion to high ethanol concentrations, increased sensitivity to the effects of ethanol on postural control, and negative tolerance/sensitization (i.e., a reduction of the increased resistance to ethanol's effects that normally occurs upon repeated exposure).
  • These data strongly indicate a linkage between ethanol-induced behavior and ethanol metabolism in adult fruit flies: Adh deficiency resulted in reduced preference to low ethanol concentrations and reduced aversion to high ones, despite recovery from ethanol being strongly impaired.

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  • (PMID = 20739429.001).
  • [ISSN] 1464-3553
  • [Journal-full-title] Chemical senses
  • [ISO-abbreviation] Chem. Senses
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alcohols; 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase
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11. Shafe S, Gilder DA, Montane-Jaime LK, Josephs R, Moore S, Crooks H, Ramcharam C, Ehler CL: Co-morbidity of alcohol dependence and select affective and anxiety disorders among individuals of East Indian and African ancestry in Trinidad and Tobago. West Indian Med J; 2009 Mar;58(2):164-72
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  • A blood sample was obtained and used to genotype for the presence of ADH and ALDH1 polymorphisms and serum levels of hepatic enzymes.
  • Co-morbidity of major depressive disorder with alcohol dependence is common in the two major ethnic groups in Trinidad and Tobago and appears to be as likely the consequence of drinking and/or drug use, as the cause.

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  • (PMID = 20953317.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / P50 AA006420; United States / NIAAA NIH HHS / AA / AA014370-03; United States / NIAAA NIH HHS / AA / R21 AA014370-03; United States / NIAAA NIH HHS / AA / AA006420; United States / NIAAA NIH HHS / AA / AA014370; United States / NIAAA NIH HHS / AA / P60 AA006420-250023; United States / NIAAA NIH HHS / AA / AA006420-250023; United States / NIAAA NIH HHS / AA / P60 AA006420; United States / NIAAA NIH HHS / AA / R21 AA014370
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Jamaica
  • [Chemical-registry-number] EC 1.4.1.1 / Alanine Dehydrogenase
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12. Fritzsche FR, Dietel M, Kristiansen G: [Flat epithelial neoplasia and other columnar cell lesions of the breast]. Pathologe; 2006 Sep;27(5):381-6
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  • [Title] [Flat epithelial neoplasia and other columnar cell lesions of the breast].
  • The entity of flat epithelial neoplasia remains a challenge for surgical pathologists due to its uncertain biological and clinical significance, inconsistent nomenclature, lack of prognostic data and the often unobtrusive and easily overlooked histological findings.
  • Because of its putative role as a precursor lesion and its many similarities to atypical ductal hyperplasia or ductal carcinoma in situ, differentiation from these lesions on the one hand and from columnar cell lesions without atypia on the other, is of importance and should result in different therapeutic recommendations depending on its presence in excisional or core needle biopsies.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Terminology as Topic

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  • (PMID = 16858557.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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13. Starek A, Szabla J, Starek-Swiechowicz B: Pyrazole and methylpyrazole for the treatment of 2-butoxyethanol poisoning. Acta Pol Pharm; 2007 Jan-Feb;64(1):93-100
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  • These data confirm the beneficial role of alcohol dehydrogenase (ADH) inhibitors in BE intoxication.

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  • (PMID = 17665857.001).
  • [ISSN] 0001-6837
  • [Journal-full-title] Acta poloniae pharmaceutica
  • [ISO-abbreviation] Acta Pol Pharm
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antidotes; 0 / Ethylene Glycols; 0 / Pyrazoles; 3QD5KJZ7ZJ / pyrazole; 83LCM6L2BY / fomepizole; EC 1.1.1.1 / Alcohol Dehydrogenase; I0P9XEZ9WV / n-butoxyethanol
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14. Pozzessere D, Zafarana E, Buccoliero AM, Pratesi C, Fargnoli R, Di Leo A: Gastric cancer metastatic to the pituitary gland: a case report. Tumori; 2007 Mar-Apr;93(2):217-9
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  • Basal endocrinological work-up showed corticotroph, gonadotroph, somatotroph and thyrotroph cell insufficiency; serum PRL was elevated and no deficit of the ADH level was observed.
  • After diagnosis the patient began thyroid and adrenal-replacement therapy and was referred to Radiotherapy Unit for treatment on the sellar and pituitary gland region.


15. Quigley R, Chu PY, Huang CL: Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability. J Membr Biol; 2005 Apr;204(3):109-16
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  • [Title] Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability.
  • The mammalian renal collecting duct increases its water permeability in response to antidiuretic hormone (ADH).
  • ADH causes cytoplasmic endosomes containing the water channel, aquaporin 2 (AQP 2), to fuse with the apical membrane so that the water permeability of the tubule increases many times above baseline.
  • In the present study, we examined the role of SNARE proteins in the insertion of water channels in the collecting-duct response to ADH by using botulinum toxins A, B and C.
  • ADH (200 pM) was then added to the bath after baseline measurements of osmotic water permeability (P(f)) and the change in P(f) was followed for one hour.
  • Thus, SNARE proteins are involved in the insertion of the water channels in the collecting duct.

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  • (PMID = 16245033.001).
  • [ISSN] 0022-2631
  • [Journal-full-title] The Journal of membrane biology
  • [ISO-abbreviation] J. Membr. Biol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK54368
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aquaporin 2; 0 / Aquaporins; 0 / SNARE Proteins; 0 / Vesicular Transport Proteins; 059QF0KO0R / Water; 11000-17-2 / Vasopressins; EC 3.4.24.69 / Botulinum Toxins
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16. Troxell ML, Levine J, Beadling C, Warrick A, Dunlap J, Presnell A, Patterson J, Shukla A, Olson NR, Heinrich MC, Corless CL: High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Mod Pathol; 2010 Jan;23(1):27-37
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  • [Title] High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast.
  • Papillary lesions of the breast have an uncertain relationship to the histogenesis of breast carcinoma, and are thus diagnostically and managerially challenging.
  • Molecular genetic studies have provided evidence that ductal carcinoma in situ and even atypical ductal hyperplasia are precursors of invasive carcinoma.
  • We screened papillary breast neoplasms for activating point mutations in PIK3CA, AKT1, and RAS protein-family members, which are common in invasive ductal carcinomas.
  • DNA extracts were prepared from sections of 89 papillary lesions, including 61 benign papillomas (28 without significant hyperplasia; 33 with moderate to florid hyperplasia), 11 papillomas with atypical ductal hyperplasia, 7 papillomas with carcinoma in situ, and 10 papillary carcinomas.
  • Papillomas had more mutations in AKT1 (54%) than in PIK3CA (21%), whereas papillomas with hyperplasia had more PIK3CA (42%) than AKT1 (15%) mutations, as did papillomas with atypical ductal hyperplasia (PIK3CA 45%, AKT1 27%, and NRAS 9%).
  • [MeSH-major] Breast Neoplasms / genetics. Carcinoma, Papillary / genetics. Phosphatidylinositol 3-Kinases / genetics. Proto-Oncogene Proteins c-akt / genetics


17. Otto B, Riepl RL, Otto C, Klose J, Enck P, Klosterhalfen S: mu-Opiate receptor agonists -- a new pharmacological approach to prevent motion sickness? Br J Clin Pharmacol; 2006 Jan;61(1):27-30
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  • Plasma antidiuretic hormone (ADH), adrenocorticotropic hormone (ACTH) and nausea ratings were investigated.
  • ACTH (P < 0.05) and ADH levels (P < 0.02) increased significantly in both settings, but were lower after loperamide.

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  • (PMID = 16390348.001).
  • [ISSN] 0306-5251
  • [Journal-full-title] British journal of clinical pharmacology
  • [ISO-abbreviation] Br J Clin Pharmacol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Opioid, mu; 11000-17-2 / Vasopressins; 6X9OC3H4II / Loperamide; 9002-60-2 / Adrenocorticotropic Hormone
  • [Other-IDs] NLM/ PMC1884979
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18. Manríquez D, El-Sharkawy I, Flores FB, El-Yahyaoui F, Regad F, Bouzayen M, Latché A, Pech JC: Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics. Plant Mol Biol; 2006 Jul;61(4-5):675-85
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  • Alcohol dehydrogenases (ADH) participate in the biosynthetic pathway of aroma volatiles in fruit by interconverting aldehydes to alcohols and providing substrates for the formation of esters.
  • Two highly divergent ADH genes (15% identity at the amino acid level) of Cantaloupe Charentais melon (Cucumis melo var.
  • Cm-ADH1 belongs to the medium-chain zinc-binding type of ADHs and is highly similar to all ADH genes expressed in fruit isolated so far.
  • Both Cm-ADH proteins are much more active as reductases with K (m)s 10-20 times lower for the conversion of aldehydes to alcohols than for the dehydrogenation of alcohols to aldehydes.
  • Both Cm-ADH genes are expressed specifically in fruit and up-regulated during ripening.
  • Gene expression as well as total ADH activity are strongly inhibited in antisense ACC oxidase melons and in melon fruit treated with the ethylene antagonist 1-methylcyclopropene (1-MCP), indicating a positive regulation by ethylene.
  • These data suggest that each of the Cm-ADH protein plays a specific role in the regulation of aroma biosynthesis in melon fruit.

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  • (PMID = 16897483.001).
  • [ISSN] 0167-4412
  • [Journal-full-title] Plant molecular biology
  • [ISO-abbreviation] Plant Mol. Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ ABC02081/ ABC02082
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aldehydes; 0U46U6E8UK / NAD; 53-59-8 / NADP; EC 1.1.1.1 / Alcohol Dehydrogenase
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19. Chun J, Pocock B, Joseph KA, El-Tamer M, Klein L, Schnabel F: Breast cancer risk factors in younger and older women. Ann Surg Oncol; 2009 Jan;16(1):96-9
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  • [Title] Breast cancer risk factors in younger and older women.
  • Information is lacking regarding the interaction of established breast cancer risk factors and patient age.
  • Enrollment criteria included: strong family history of breast cancer (FHBC), and/or biopsy-proven history of atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), or lobular carcinoma in situ (LCIS).
  • Descriptive analyses and Fisher's exact tests were used to analyze these factors and to assess their influence on breast cancer development.
  • Of 195 women < or =35 years, 3 (1.5%) developed breast cancer.
  • Of 82 women > or =70 years, 6 (7.3%) developed breast cancer.
  • Fisher's tests demonstrated that ADH (p = 0.15), ALH (p = 1.0), LCIS (p = 1.0), and FHBC (p = 1.0) were not associated with breast cancer development in older women.
  • We conclude that, for women < or =35 years, a significant FHBC may be a stronger predictor for breast cancer development than high-risk lesions.
  • For women > or =70 years, FHBC and history of ADH, ALH, and LCIS were not predictors of breast cancer.
  • This study emphasizes the importance of defining age-appropriate recommendations for breast cancer risk management, including surveillance and chemoprevention.
  • [MeSH-major] Breast Neoplasms / etiology. Carcinoma in Situ / etiology. Carcinoma, Ductal, Breast / etiology. Carcinoma, Lobular / etiology. Hyperplasia / etiology

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  • (PMID = 18979140.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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20. Espinosa A, Perdrizet G, Paz-Y-Miño C G, Lanfranchi R, Phay M: Effects of iron depletion on Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) and trophozoite growth: implications for antiamoebic therapy. J Antimicrob Chemother; 2009 Apr;63(4):675-8
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  • Fe2+ is a cofactor for E. histolytica alcohol dehydrogenase 2 (EhADH2), an essential bifunctional enzyme [alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)] in the glycolytic pathway of E. histolytica.
  • METHODS: We tested the effects of iron depletion on trophozoite growth, the kinetics of iron binding to EhADH2, and the activities of ADH and ALDH.
  • RESULTS: Growth of E. histolytica trophozoites, and ADH and ALDH enzymatic activities were directly inhibited by iron chelation.
  • Kinetics of iron binding to EhADH2 reveals the differential iron affinity of ADH (higher) and ALDH (lower).

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  • (PMID = 19218278.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / 2 P20 RR16457-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iron Chelating Agents; E1UOL152H7 / Iron; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / Aldehyde Dehydrogenase
  • [Other-IDs] NLM/ PMC2721693
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21. Caseli L, Perinotto AC, Viitala T, Zucolotto V, Oliveira ON Jr: Immobilization of alcohol dehydrogenase in phospholipid Langmuir-Blodgett films to detect ethanol. Langmuir; 2009 Mar 3;25(5):3057-61
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  • Here we show that alcohol dehydrogenase (ADH) has high affinity toward a negatively charged phospholipid, dimyristoylphosphatidic acid (DMPA), which forms a Langmuir monolayer at an air-water interface.
  • Incorporation of ADH into the DMPA monolayer was monitored with surface pressure measurements and polarization-modulation infrared reflection absorption spectroscopy, with the alpha-helices from ADH being mainly oriented parallel to the water surface.
  • ADH remained at the interface even at high surface pressures, thus allowing deposition of Langmuir-Blodgett (LB) films from the DMPA-ADH film.
  • Indeed, interaction with DMPA enhances the transfer of ADH, where the mass transferred onto a solid support increased from 134 ng for ADH on a Gibbs monolayer to 178 ng for an LB film with DMPA.
  • With fluorescence spectroscopy it was possible to confirm that the ADH structure was preserved even after one month of the LB deposition.
  • ADH-containing films deposited onto gold-interdigitated electrodes were employed in a sensor array capable of detecting ethanol at concentrations down to 10 ppb (in volume), using impedance spectroscopy as the method of detection.

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  • (PMID = 19437773.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Buffers; 0 / Enzymes, Immobilized; 0 / Phospholipids; 059QF0KO0R / Water; 3K9958V90M / Ethanol; 701-56-4 / N,N-dimethyl-4-anisidine; EC 1.1.1.1 / Alcohol Dehydrogenase
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22. Eanes WF, Merritt TJ, Flowers JM, Kumagai S, Zhu CT: Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster. Genetics; 2009 Feb;181(2):607-14
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  • Many studies of alcohol adaptation in Drosophila melanogaster have focused on the Adh polymorphism, yet the metabolic elimination of alcohol should involve many enzymes and pathways.
  • We have created a set of P-element-excision-derived Gpdh, Mdh1, and Adh alleles that generate a range of activity phenotypes from full to zero activity.
  • Finally, we examine the interactions between activity genotypes for Gpdh, Mdh1, and Adh.
  • Observations on Mdh1 in both Gpdh and Adh backgrounds demonstrate significant increases in ethanol tolerance with partial reductions (50%) in cytosolic MDH activity.

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  • (PMID = 19033156.001).
  • [ISSN] 0016-6731
  • [Journal-full-title] Genetics
  • [ISO-abbreviation] Genetics
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM045247; United States / NIGMS NIH HHS / GM / GM-45247
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; EC 1.1.- / Glycerolphosphate Dehydrogenase; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.37 / Malate Dehydrogenase
  • [Other-IDs] NLM/ PMC2644950
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23. Dabbs DJ, Bhargava R, Chivukula M: Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin. Am J Surg Pathol; 2007 Mar;31(3):427-37
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  • [Title] Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin.
  • The distinction between lobular and ductal lesions of the breast is important in several circumstances.
  • Diagnostic reproducibility of lobular versus ductal lesions, based on histology alone, is less than optimal.
  • The proper distinction between atypical lobular hyperplasia, lobular carcinoma in situ and low-grade ductal carcinoma in situ is critical for patient management.
  • E-cadherin, a negative membrane marker for lobular neoplasia, is useful in the distinction of lobular versus ductal neoplasia, but as a negative marker, can be difficult to interpret in particularly challenging cases.
  • In this study, we surveyed primary and metastatic ductal lesions (62) and lobular lesions (64) of the breast to determine if P120 catenin is useful in the diagnostic distinction between lobular and ductal neoplasia.
  • Primary breast ductal and lobular preneoplastic and neoplastic lesions were immunostained with E-cadherin and P120ctn and independently classified as ductal or lobular lesions.
  • In addition, a wide array of carcinomas of different types were surveyed with P120ctn in tissue microarrays to ascertain whether the cytoplasmic P120ctn immunostaining pattern observed in lobular neoplasia was unique.
  • Accurate categorization of ductal versus lobular neoplasia in the breast with P120ctn immunostaining was effective in all cases.
  • Separation of low-grade ductal carcinoma in situ from lobular neoplasia was efficient.
  • Diagnostically, P120ctn was particularly useful in identifying early lesions of lobular neoplasia.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Lobular / diagnosis. Cell Adhesion Molecules / metabolism. Phosphoproteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cadherins / metabolism. Catenins. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Reproducibility of Results. Tissue Array Analysis

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  • (PMID = 17325485.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Catenins; 0 / Cell Adhesion Molecules; 0 / Phosphoproteins; 0 / delta catenin
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24. Li SY, Ren J: Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. J Mol Cell Cardiol; 2008 Jun;44(6):992-1001
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  • This study examined the impact of augmented acetaldehyde exposure on myocardial function, geometry, and insulin signaling via cardiac-specific overexpression of alcohol dehydrogenase (ADH).
  • ADH transgenic and wild-type FVB mice were placed on a 4% alcohol diet for 12 weeks.
  • Mice consuming alcohol exhibited glucose intolerance, dampened cardiac glucose uptake, cardiac hypertrophy and contractile dysfunction, all of which with the exception of whole body glucose tolerance were exaggerated by the ADH transgene.
  • ADH-augmented alcohol-induced effect of IRS-1 phosphorylation (tyrosine/serine).
  • Neither alcohol nor adh affected expression of insulin receptor and IRS-1.
  • Alcohol reduced phosphorylation of Akt and GSK-3beta as well as GSK-3beta expression and the effect was exaggerated by ADH.
  • The transcriptional factors GATA4, c-jun and c-jun phosphorylation were upregulated by alcohol, which was amplified by ADH.
  • Chronic alcohol intake upregulated expression of the endoplasmic reticulum stress markers eIF2alpha, IRE-1alpha, GRP78 and gadd153, the effect of which was exaggerated by ADH.
  • These data suggest that elevated cardiac acetaldehyde exposure via ADH may exacerbate alcohol-induced myocardial dysfunction, hypertrophy, insulin insensitivity and ER stress, indicating a key role of ADH gene in alcohol-induced cardiac dysfunction and insulin resistance.

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  • (PMID = 18377926.001).
  • [ISSN] 1095-8584
  • [Journal-full-title] Journal of molecular and cellular cardiology
  • [ISO-abbreviation] J. Mol. Cell. Cardiol.
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / R01 AA013412-03; United States / NIAAA NIH HHS / AA / AA013412-05; United States / NIAAA NIH HHS / AA / R01 AA013412-05; United States / NIAAA NIH HHS / AA / AA013412-02; United States / NCRR NIH HHS / RR / P20 RR016474-08; United States / NCRR NIH HHS / RR / P20 RR016474; United States / NIAAA NIH HHS / AA / R01 AA013412-02; United States / NCRR NIH HHS / RR / 5P20RR016474; United States / NIAAA NIH HHS / AA / R01 AA013412; United States / NIAAA NIH HHS / AA / AA013412-03; United States / NIAAA NIH HHS / AA / R01 AA013412-04; United States / NIAAA NIH HHS / AA / R01 AA013412-01A2; United States / NIAAA NIH HHS / AA / 1R01 AA013412; United States / NIAAA NIH HHS / AA / AA013412-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Central Nervous System Depressants; 0 / Ddit3 protein, mouse; 0 / Eukaryotic Initiation Factor-2; 0 / GATA4 Transcription Factor; 0 / Gata4 protein, mouse; 0 / Heat-Shock Proteins; 0 / Insulin; 0 / Insulin Receptor Substrate Proteins; 0 / Irs1 protein, mouse; 0 / Molecular Chaperones; 0 / molecular chaperone GRP78; 147336-12-7 / Transcription Factor CHOP; 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 2.7.11.1 / Ern1 protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3; EC 3.1.- / Endoribonucleases; GO1N1ZPR3B / Acetaldehyde; IY9XDZ35W2 / Glucose
  • [Other-IDs] NLM/ NIHMS56327; NLM/ PMC2501109
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25. Varret M, Abifadel M, Rabès JP, Boileau C: Genetic heterogeneity of autosomal dominant hypercholesterolemia. Clin Genet; 2008 Jan;73(1):1-13
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  • Autosomal dominant hypercholesterolemia (ADH) is characterized by isolated elevation of plasmatic low-density lipoprotein cholesterol associated with high risk of premature cardiovascular complications.
  • We have shown further heterogeneity with the discovery of missense mutations in the PCSK9 gene resulting in ADH.
  • Altogether, numerous reports give evidence for the existence of a greater level of genetic heterogeneity in ADH and the involvement of still unknown genes.

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  • (PMID = 18028451.001).
  • [ISSN] 1399-0004
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 3.4.- / Proprotein Convertases; EC 3.4.21.- / PCSK9 protein, human; EC 3.4.21.- / Serine Endopeptidases
  • [Number-of-references] 88
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26. Schlenke TA, McKean KA: A role for alcohol dehydrogenase in the Drosophila immune response? Insect Mol Biol; 2005 Apr;14(2):175-8
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  • The levels of several proteins, including alcohol dehydrogenase (ADH), increased in LPS-treated flies and were labelled as immune response proteins.
  • While ADH activity increased in larvae receiving 1% ethanol, it was not increased after LPS injection.
  • These results suggest that ADH plays no role in the Drosophila immune response, and that other proteins identified in the previous study may instead mediate ethanol tolerance in flies and other organisms.

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  • (PMID = 15796750.001).
  • [ISSN] 0962-1075
  • [Journal-full-title] Insect molecular biology
  • [ISO-abbreviation] Insect Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / F32 GM067504
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Insect Proteins; 0 / Lipopolysaccharides; 0U46U6E8UK / NAD; 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase
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27. van Bodegom PM, Sorrell BK, Oosthoek A, Bakker C, Aerts R: Separating the effects of partial submergence and soil oxygen demand on plant physiology. Ecology; 2008 Jan;89(1):193-204
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  • Increased SOD increased root oxygen deprivation, as indicated by either raised porosity or increased alcohol dehydrogenase (ADH) activity in roots of flood-intolerant species (Calamagrostis epigejos and Carex arenaria).
  • In contrast, the most flood-tolerant species (Juncus subnodulosus and Typha latifolia) were unaffected by any treatment and maintained high internal oxygen concentrations at the shoot : root junction and low root ADH activity in all treatments.

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  • (PMID = 18376561.001).
  • [ISSN] 0012-9658
  • [Journal-full-title] Ecology
  • [ISO-abbreviation] Ecology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Soil; 059QF0KO0R / Water; EC 1.1.1.1 / Alcohol Dehydrogenase; S88TT14065 / Oxygen
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28. Terry MB, Gammon MD, Zhang FF, Vaughan TL, Chow WH, Risch HA, Schoenberg JB, Mayne ST, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF Jr, Santella RM: Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas. Cancer Causes Control; 2007 Nov;18(9):1039-46
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  • RESULTS: Individuals homozygous for ADH ( 3 ) (1-1) had a higher risk of each tumor type compared to individuals who had ADH ( 3 ) (2-2) or ADH ( 3 ) (1-2) genotype (OR = 1.7, 95% CI = 1.0-2.9 for esophageal and gastric cardia adenocarcinomas; OR = 1.7, 95% CI = 0.7-4.3 for esophageal squamous cell carcinoma; and OR = 2.8, 95% CI = 1.5-5.1 for non-cardia gastric cancer).
  • The elevation in risk from homozygosity of the ADH ( 3 ) (1) allele was seen in drinkers and nondrinkers, although the risk estimate was only significant for drinkers, particularly of liquor.

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  • (PMID = 17665311.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01-CA57923; United States / NCI NIH HHS / CA / U01-CA57983; United States / NCI NIH HHS / CN / N01-CN05230; United States / NCI NIH HHS / CA / U01-CA57949; United States / NCI NIH HHS / CP / N02-CP40501; United States / NIEHS NIH HHS / ES / P30-ES09089; United States / NIEHS NIH HHS / ES / P30-ES10126; United States / NIEHS NIH HHS / ES / P30 ES009089
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase
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29. Macgregor S, Lind PA, Bucholz KK, Hansell NK, Madden PA, Richter MM, Montgomery GW, Martin NG, Heath AC, Whitfield JB: Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet; 2009 Feb 1;18(3):580-93
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  • [Title] Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
  • Alcohol dependence (AD) is a complex disorder with environmental and genetic origins.
  • This study tested for associations between nine polymorphisms in ALDH2 and 41 in the seven ADH genes, and alcohol-related flushing, alcohol use and dependence symptom scores in 4597 Australian twins.

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  • (PMID = 18996923.001).
  • [ISSN] 1460-2083
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / AA13320; United States / NIAAA NIH HHS / AA / AA13321; United States / NIAAA NIH HHS / AA / AA013326; United States / NIAAA NIH HHS / AA / AA07728; United States / NIAAA NIH HHS / AA / AA11998; United States / NIAAA NIH HHS / AA / AA014041; United States / NIAAA NIH HHS / AA / AA07535
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / ALDH2 protein, human; EC 1.2.1.3 / Aldehyde Dehydrogenase
  • [Other-IDs] NLM/ PMC2722191
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30. Rahko E, Kauppila S, Pääkkö P, Blanco G, Apaja-Sarkkinen M, Talvensaari-Mattila A, Turpeenniemi-Hujanen T, Jukkola A: Immunohistochemical study of matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinase 1 in benign and malignant breast tissue--strong expression in intraductal carcinomas of the breast. Tumour Biol; 2009;30(5-6):257-64
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  • [Title] Immunohistochemical study of matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinase 1 in benign and malignant breast tissue--strong expression in intraductal carcinomas of the breast.
  • Only few data exist on MMP-9 or TIMP-1 expression in tissue samples of different breast histology.
  • METHODS: MMP-9 and TIMP-1 immunoreactivity was examined in a wide range of breast tissue samples differing in histology from usual ductal hyperplasia (UDH) to fully developed ductal breast carcinoma.
  • Immunohistochemical expression of MMP-9 was studied in 178 samples: 31 UDH samples, 29 atypical ductal hyperplasia (ADH) samples, 28 ductal carcinoma in situ (DCIS) samples and 90 ductal invasive carcinoma samples (30 samples of malignancy grades I, II and III, respectively).
  • TIMP-1 expression was also analyzed in 178 breast tissue samples: 41 UDH, 21 ADH and 34 DCIS lesions, and 82 invasive ductal breast carcinomas (25 in grade I, 30 in grade II and 27 in grade III).
  • Negative or weakly positive MMP-9 staining was the most prominent finding in UDH (71%), ADH (69%) as well as in invasive carcinoma samples (64.4%).
  • CONCLUSIONS: These results suggest that MMP-9 and TIMP-1 overexpression are early markers of breast carcinogenesis preceding tumor invasion.
  • [MeSH-major] Breast Neoplasms / enzymology. Breast Neoplasms / pathology. Matrix Metalloproteinase 9 / biosynthesis. Tissue Inhibitor of Metalloproteinase-1 / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / biosynthesis. Breast / enzymology. Breast / pathology. Carcinoma, Ductal, Breast / enzymology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / enzymology. Carcinoma, Intraductal, Noninfiltrating / pathology. Female. Humans. Hyperplasia. Immunohistochemistry

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  • [Copyright] (c) 2009 S. Karger AG, Basel.
  • (PMID = 19887890.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.35 / Matrix Metalloproteinase 9
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31. Haris A, Demeter P, Tóth I, Polner K: [Severe hyponatremia and comatose state during colonoscopy preparation]. Orv Hetil; 2010 May 16;151(20):828-31
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  • Hyponatremia was likely induced by stress provoked ADH secretion, due to the patients' fear for bowel cleansing and colonoscopy, and by large fluid intake consumed as "misunderstanding" of the instructions.
  • [MeSH-major] Colonoscopy. Coma / etiology. Drinking. Hyponatremia / etiology. Inappropriate ADH Syndrome / etiology

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  • (PMID = 20442054.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Laxatives; 0 / Phosphates; 9NEZ333N27 / Sodium; RWP5GA015D / Potassium; SE337SVY37 / sodium phosphate
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32. Ghosh S, Bierut LJ, Porjesz B, Edenberg HJ, Dick D, Goate A, Hesselbrock V, Nurnberger J Jr, Foroud T, Kramer J, Rice J, Begleiter H: A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs. Am J Med Genet B Neuropsychiatr Genet; 2008 Oct 5;147B(7):1301-5
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  • We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4.

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  • (PMID = 18454434.001).
  • [ISSN] 1552-485X
  • [Journal-full-title] American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • [ISO-abbreviation] Am. J. Med. Genet. B Neuropsychiatr. Genet.
  • [Language] ENG
  • [Grant] United States / FIC NIH HHS / TW / R01 TW006604; United States / FIC NIH HHS / TW / R01 TW006604-05; United States / FIC NIH HHS / TW / R01-TW-6604; United States / NIAAA NIH HHS / AA / U10AA08403
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ NIHMS203246; NLM/ PMC2879266
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33. Trivedi AH, Spiess AC, Daussmann T, Büchs J: Study on mesophilic and thermophilic alcohol dehydrogenases in gas-phase reaction. Biotechnol Prog; 2006 Mar-Apr;22(2):454-8
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  • The initial reaction rate and the thermostability of the mesophilic alcohol dehydrogenase (ADH) from Lactobacillus brevis (LBADH), and the thermophilic ADH from Thermoanaerobacter sp. (ADH T) in gas-phase reaction were compared.
  • An excellent optimal productivity of 1,000 g x L(-1) x d(-1) for LBADH and 600 g x L(-1) x d(-1)for ADH T was found at 60 degrees C, while the highest total turnover numbers with respect to the enzyme were achieved at 30 degrees C and amounted to 4.2 million for LBADH and 1.7 million for ADH T, respectively.
  • Interestingly, the ADH from the mesophilic L. brevisshowed the higher thermostability in the nonconventional medium gas phase.

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  • (PMID = 16599562.001).
  • [ISSN] 8756-7938
  • [Journal-full-title] Biotechnology progress
  • [ISO-abbreviation] Biotechnol. Prog.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzymes, Immobilized; 059QF0KO0R / Water; EC 1.1.1.1 / Alcohol Dehydrogenase
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34. Simpson PT, Reis-Filho JS, Gale T, Lakhani SR: Molecular evolution of breast cancer. J Pathol; 2005 Jan;205(2):248-54
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  • [Title] Molecular evolution of breast cancer.
  • Molecular analysis of invasive breast cancer and its precursors has furthered our understanding of breast cancer progression.
  • In the past few years, new multi-step pathways of breast cancer progression have been delineated through genotypic-phenotypic correlations.
  • Nuclear grade, more than any other pathological feature, is strongly associated with the number and pattern of molecular genetic abnormalities in breast cancer cells.
  • Thus, there are two distinct major pathways to the evolution of low- and high-grade invasive carcinomas: whilst the former consistently show oestrogen receptor (ER) and progesterone receptor (PgR) positivity and 16q loss, the latter are usually ER/PgR-negative and show Her-2 overexpression/amplification and complex karyotypes.
  • The boundaries between the evolutionary pathways of well-differentiated/low-grade ductal and lobular carcinomas have been blurred, with changes in E-cadherin expression being one of the few distinguishing features between the two.
  • In addition, lesions long thought to be precursors of breast carcinomas, such as hyperplasia of usual type, are currently considered mere risk indicators, whilst columnar cell lesions are now implicated as non-obligate precursors of atypical ductal hyperplasia (ADH) and well-differentiated ductal carcinoma in situ (DCIS).
  • [MeSH-major] Breast Neoplasms / genetics


35. García-Otín AL, Cofán M, Junyent M, Recalde D, Cenarro A, Pocoví M, Ros E, Civeira F: Increased intestinal cholesterol absorption in autosomal dominant hypercholesterolemia and no mutations in the low-density lipoprotein receptor or apolipoprotein B genes. J Clin Endocrinol Metab; 2007 Sep;92(9):3667-73
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  • CONTEXT: Autosomal dominant hypercholesterolemia (ADH) is frequently caused by functional mutations in the low-density lipoprotein receptor (LDLR) or apolipoprotein B-100 (APOB) genes, but approximately 40% of ADH subjects disclose no such molecular defects, possibly pointing to alternative genetic mechanisms.
  • OBJECTIVE: Our objective was to test the hypothesis that increased intestinal cholesterol absorption might play a role in the lipid abnormalities of subjects with ADH without identified genetic defects.
  • STUDY SUBJECTS: A total of 52 subjects with a clinical diagnosis of ADH were examined for molecular defects in LDLR and APOB.
  • Functional LDLR mutations occurred in 31 (60%) subjects, who received a diagnosis of familial hypercholesterolemia (FH).
  • Those for whom no mutations could be identified were labeled as non-FH ADH.
  • RESULTS: Adjusted campesterol to cholesterol ratios increased in the order non-FH ADH more than FH more than controls more than FCH, with mean values (95% confidence interval) in 10(2) mmol/mol cholesterol of 505 (424-600), 397 (345-458), 335 (294-382), and 284 (247-328), respectively.
  • Thus, cholesterol absorption was lowest in FCH and highest in non-FH ADH.
  • CONCLUSIONS: Increased intestinal cholesterol absorption may partially explain the high cholesterol levels of non-FH ADH subjects.
  • Serum noncholesterol sterols are a useful tool for the differential diagnosis of genetic hypercholesterolemias, especially FCH and ADH unrelated to LDLR or APOB defects.

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  • (PMID = 17566095.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins B; 0 / Receptors, LDL; 0 / Sterols; 97C5T2UQ7J / Cholesterol
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36. Campos FM, Liarte DB, Mortara RA, Romanha AJ, Murta SM: Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi. Acta Trop; 2009 Jul;111(1):56-63
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  • Alcohol dehydrogenases (ADH) are a class of oxidoreductases that catalyse the reversible oxidation of ethanol to acetaldehyde.

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  • (PMID = 19426664.001).
  • [ISSN] 1873-6254
  • [Journal-full-title] Acta tropica
  • [ISO-abbreviation] Acta Trop.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Protozoan; 0 / Nitroimidazoles; 0 / Protozoan Proteins; 0 / RNA, Messenger; 0 / RNA, Protozoan; 0 / Trypanocidal Agents; EC 1.1.1.1 / Alcohol Dehydrogenase; M84I3K7C2O / Nifurtimox; YC42NRJ1ZD / benzonidazole
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37. Trabold R, Krieg S, Schöller K, Plesnila N: Role of vasopressin V(1a) and V2 receptors for the development of secondary brain damage after traumatic brain injury in mice. J Neurotrauma; 2008 Dec;25(12):1459-65
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  • The goal of the current study was to investigate the role of arginine vasopressin (AVP), also known as antidiuretic hormone (ADH), an important regulator of tissue water homeostasis, for the formation of post-traumatic brain edema, intracranial pressure (ICP), brain damage, and functional deficits following brain trauma.

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  • (PMID = 19118456.001).
  • [ISSN] 0897-7151
  • [Journal-full-title] Journal of neurotrauma
  • [ISO-abbreviation] J. Neurotrauma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antidiuretic Hormone Receptor Antagonists; 0 / Receptors, Vasopressin; 113-79-1 / Arginine Vasopressin
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38. Zhang W, SLi, Visocchi M, Jiang J, Wang X: Natriuretic peptides, antidiuretic hormone and hyponatraemia after acute craniocerebral injury. J Int Med Res; 2008 Jul-Aug;36(4):648-55
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  • We measured blood concentrations of natriuretic peptides, antidiuretic hormone (ADH), and endogenous digitalis-like substance (EDLS), blood and urine sodium concentrations, and the plasma and urine osmolality in 68 patients with ACI and 24 healthy control subjects.
  • Blood concentrations of EDLS and ADH in hyponatraemic ACI patients were significantly higher compared with normonatraemic ACI patients and control subjects.

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  • (PMID = 18652759.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cardenolides; 0 / Natriuretic Peptides; 0 / Saponins; 0 / digoxin-like factors; 11000-17-2 / Vasopressins
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39. Montane-Jaime K, Moore S, Shafe S, Joseph R, Crooks H, Carr L, Ehlers CL: ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago. Alcohol; 2006 Jun;39(2):81-6
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  • Variants in alcohol dehydrogenase (ADH) genes differ between ethnic groups and have, in some studies, been found to be associated with alcohol dependence and alcoholic liver disease.
  • This study sought to determine whether an association exists between ADH (ADH1C previously ADH3, ADH1B*2 previously ADH2*2) genotypes, alcohol dependence, drinking history, and liver function tests in the two major ethnic groups of Trinidad and Tobago (TT).

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  • (PMID = 17134660.001).
  • [ISSN] 0741-8329
  • [Journal-full-title] Alcohol (Fayetteville, N.Y.)
  • [ISO-abbreviation] Alcohol
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / R21 AA014370; United States / PHS HHS / / 014370; United States / PHS HHS / / 06420; United States / NIAAA NIH HHS / AA / AA07611
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 2.3.2.2 / gamma-Glutamyltransferase; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase; EC 3.1.3.1 / Alkaline Phosphatase
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40. Alberti C: [Paraneoplastic syndromes associated with urogenital tumours: an up-to-date review]. G Chir; 2008 Oct;29(10):437-48
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  • On the basis of an up-to-date review of the literature, this article discusses pathogenetic mechanisms, diagnostic features and essential therapeutic measures concerning the syndromes of inappropriate ACTH/CRH, PTHrp, TRH/TSH, ADH and MSH secretion.

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  • (PMID = 18947470.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Cytokines; 0 / Intercellular Signaling Peptides and Proteins; 0 / Peptide Hormones; 333DO1RDJY / Serotonin
  • [Number-of-references] 89
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41. Theman TA, Collins MT, Dempster DW, Zhou H, Reynolds JC, Brahim JS, Roschger P, Klaushofer K, Winer KK: PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation. J Bone Miner Res; 2009 May;24(5):964-73
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  • Autosomal dominant hypocalcemia (ADH) is an inherited form of hypoparathyroidism caused by activating mutations in the calcium-sensing receptor (CaR).
  • The patient is a 20-yr-old female with ADH treated with PTH continuously since 6 yr and 2 mo of age.
  • Her data were compared with one age-, sex-, and length of hypoparathyroidism-matched control not on PTH and two sex-matched ADH controls before and after 1 yr of PTH.
  • Cancellous bone volume was dramatically elevated in the patient and in ADH controls after 1 yr of PTH.
  • BMD distribution (BMDD) by qBEI of the patient and ADH controls was strikingly shifted toward lower mineralization compared with the non-ADH control.
  • Moreover, the ADH controls exhibited a further reduction in mineralization after 1 yr of PTH.
  • In conclusion, long-term PTH replacement in a child with ADH was not unsafe, increased bone mass without negatively impacting mineralization, and improved serum mineral control but did not prevent nephrocalcinosis.

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  • (PMID = 19063686.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Receptors, Calcium-Sensing
  • [Other-IDs] NLM/ PMC2672210
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42. Chen HJ, Tian H, Edenberg HJ: Natural haplotypes in the regulatory sequences affect human alcohol dehydrogenase 1C (ADH1C) gene expression. Hum Mutat; 2005 Feb;25(2):150-5
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  • Human alcohol dehydrogenases (ADHs) play important roles in metabolizing alcohol, and several lines of evidence suggest that variations in ADH genes affect the risk for alcoholism.
  • Differences in regulatory sequences could affect the expression of ADH genes and thereby modify the risk for alcoholism.

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15643610.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Databank-accession-numbers] OMIM/ 103730
  • [Grant] United States / NIAAA NIH HHS / AA / R37-AA06460
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase
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43. Yu HS, Oyama T, Isse T, Kitagawa K, Pham TT, Tanaka M, Kawamoto T: Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. Chem Biol Interact; 2010 Dec 5;188(3):367-75
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  • Ingested ethanol is mainly oxidized by the enzymes alcohol dehydrogenase (ADH), cytochrome P-450 2E1 (CYP2E1), and catalase to form acetaldehyde, which is subsequently oxidized by aldehyde dehydrogenase 2 (ALDH2) to produce acetate.
  • ADH1B*2 allele (ADH1B, one of the enzyme in ADH family) is commonly observed in Asian population, has much higher enzymatic activity than ADH1B*1 allele.

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20813101.001).
  • [ISSN] 1872-7786
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Alcohols; 0 / DNA Adducts; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / Aldehyde Dehydrogenase; GO1N1ZPR3B / Acetaldehyde
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44. Belokon' MM, Belokon' IuS, Politov DV, Altukhov IuP: [Allozyme polymorphism of Swiss stone pine Pinus cembra L. in mountainous populations of the Alps and the Eastern Carpathians]. Genetika; 2005 Nov;41(11):1538-51
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  • The allele frequencies of 30 isozyme loci, coding for enzymes ADH, FDH, FEST, GDH, GOT, IDH, LAP, MNR, MDH, PEPCA, 6PGD, PGI, PGM, SDH, SKDH, SOD, were analyzed using cluster analysis and methods of principal components.
  • The main contribution to these differences were made by loci Adh-1, Adh-2, Fest-2, Lap-3, Mdh-4, and Sod-4.

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  • (PMID = 16358721.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Enzymes; 0 / Plant Proteins
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45. Charlot A, Heyraud A, Guenot P, Rinaudo M, Auzély-Velty R: Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules. Biomacromolecules; 2006 Mar;7(3):907-13
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  • This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a reductive amination-type reaction.

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  • (PMID = 16529430.001).
  • [ISSN] 1525-7797
  • [Journal-full-title] Biomacromolecules
  • [ISO-abbreviation] Biomacromolecules
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetates; 0 / Polymers; 0 / beta-Cyclodextrins; 9004-61-9 / Hyaluronic Acid; JV039JZZ3A / betadex; PJY633525U / Adamantane; WK2XYI10QM / Ibuprofen
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46. Defilippi BG, Dandekar AM, Kader AA: Relationship of ethylene biosynthesis to volatile production, related enzymes, and precursor availability in apple peel and flesh tissues. J Agric Food Chem; 2005 Apr 20;53(8):3133-41
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  • The study was focused at the level of the aroma volatile-related enzymes, including alcohol acyltransferase (AAT), alcohol dehydrogenase (ADH), and lipoxygenase (LOX) and at the level of amino acids and fatty acids as aroma volatile precursors in peel and flesh tissues.
  • Contrarily, ADH and LOX seem to be independent of ethylene modulation.

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  • (PMID = 15826070.001).
  • [ISSN] 0021-8561
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Ethylenes; 0 / Fatty Acids; 04Y7590D77 / Isoleucine; 91GW059KN7 / ethylene; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.13.11.12 / Lipoxygenase; EC 2.3.- / Acyltransferases
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47. Das S, Devi PG, Pal S, Dasgupta D: Effect of complex formation between Zn2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase. J Biol Inorg Chem; 2005 Jan;10(1):25-32
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  • In the second part, we have examined the effect of the association of Zn(2+) with MTR on the enzymatic activity of a typical zinc(II)-dependent alcohol dehydrogenase (ADH) from yeast.
  • We also observe a negative effect for the preincubation of ADH with MTR upon the enzymatic activity.

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  • [ISSN] 0949-8257
  • [Journal-full-title] Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
  • [ISO-abbreviation] J. Biol. Inorg. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
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48. Chae BJ, Lee A, Song BJ, Jung SS: Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy. World J Surg Oncol; 2009;7:77
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  • [Title] Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy.
  • BACKGROUND: Percutaneous core needle biopsy (CNB) is considered to be the standard technique for histological diagnosis of breast lesions.
  • But, it is less reliable for diagnosing atypical ductal hyperplasia (ADH).
  • The purpose of the present study was to predict, based on clinical and radiological findings, which cases of ADH diagnosed by CNB would be more likely to be associated with a more advanced lesion on subsequent surgical excision.
  • METHODS: Between February 2002 and December 2007, consecutive ultrasound-guided CNBs were performed on suspicious breast lesions at Seoul St. Mary's Hospital.
  • A total of 69 CNBs led to a diagnosis of ADH, and 45 patients underwent follow-up surgical excision.
  • RESULTS: Sixty-nine patients were diagnosed with ADH at CNB.
  • Of these patients, 45 underwent surgical excision and 10 (22.2%) were subsequently diagnosed with a malignancy (ductal carcinoma in situ, n = 8; invasive cancer, n = 2).
  • CONCLUSION: Age (>or= 50) at the time of biopsy is an independent predictive factor for breast cancer at surgical excision in patients with diagnosed ADH at CNB.
  • For patients diagnosed with ADH at CNB, only complete surgical excision is the suitable treatment option, because we could not find any combination of factors that can safely predict the absence of DCIS or invasive cancer in a case of ADH.
  • [MeSH-major] Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Hyperplasia / pathology
  • [MeSH-minor] Adult. Age Distribution. Biopsy, Fine-Needle / methods. Breast Diseases / diagnosis. Breast Diseases / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Forecasting. Humans. Middle Aged. Retrospective Studies. Ultrasonography, Interventional. Ultrasonography, Mammary. Vacuum

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  • (PMID = 19852801.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2771003
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49. Zhang H, Cui W, Wen J, Blankenship RE, Gross ML: Native electrospray and electron-capture dissociation in FTICR mass spectrometry provide top-down sequencing of a protein component in an intact protein assembly. J Am Soc Mass Spectrom; 2010 Dec;21(12):1966-8
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  • The intact yeast alcohol dehydrogenase (ADH) tetramer of 147 kDa was introduced into a FTICR mass spectrometer by native electrospray.
  • The results are in accord with the crystal structure of yeast ADH, which shows that the C-terminus is buried at the assembly interface, whereas the N-terminus is exposed, allowing ECD to occur.

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  • [Copyright] Copyright © 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20843701.001).
  • [ISSN] 1879-1123
  • [Journal-full-title] Journal of the American Society for Mass Spectrometry
  • [ISO-abbreviation] J. Am. Soc. Mass Spectrom.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / S10 RR025101-01; United States / NIGMS NIH HHS / GM / P41 GM103422; United States / NCRR NIH HHS / RR / S10 RR025101; United States / PHS HHS / / NCRR 1S10 025101; United States / NCRR NIH HHS / RR / P41 RR000954; United States / NCRR NIH HHS / RR / P41RR000954
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fungal Proteins; 0 / Protein Subunits; EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ NIHMS236365; NLM/ PMC2991543
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50. Arun B, Vogel KJ, Lopez A, Hernandez M, Atchley D, Broglio KR, Amos CI, Meric-Bernstam F, Kuerer H, Hortobagyi GN, Albarracin CT: High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast cancers. Cancer Prev Res (Phila); 2009 Feb;2(2):122-7
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  • [Title] High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast cancers.
  • Mutations in BRCA1 and BRCA2 increase a woman's lifetime risk of developing breast cancer by 43% to 84%.
  • It was originally postulated that BRCA1/2-associated breast cancers develop more rapidly than sporadic cancers and may lack preinvasive lesions.
  • More recent studies have found preinvasive lesions in prophylactic mastectomy specimens from mutation carriers; however, there is little information on the presence of preinvasive lesions in tissue adjacent to breast cancers.
  • Our aim is to investigate the role of preinvasive lesions in BRCA-associated breast carcinogenesis.
  • We retrospectively compared BRCA1/2-associated breast cancers and sporadic breast cancers for the prevalence of preinvasive lesions [ductal carcinoma in situ (DCIS), lobular carcinoma in situ, and atypical lobular hyperplasia] in tissue adjacent to invasive breast cancers.
  • Pathology was reviewed for 73 BRCA1/2-associated tumors from patients with breast cancer.
  • We selected 146 patients with mutation-negative breast cancer as age-matched controls.
  • Among the BRCA1/2-associated breast cancers, 59% had at least one associated preinvasive lesion compared with 75% of controls.
  • The most common preinvasive lesion in both groups was DCIS; 56% of BRCA1/2-associated breast cancers and 71% of the sporadic breast cancers had adjacent intraductal disease, respectively.
  • Preinvasive lesions, most notably DCIS, are common in BRCA1/2-associated breast cancers.
  • These findings suggest that BRCA1/2-associated breast cancers progress through the same intermediate steps as sporadic breast cancers, and that DCIS should be considered as a part of the BRCA1/2 tumor spectrum.
  • [MeSH-major] BRCA1 Protein / genetics. BRCA2 Protein / genetics. Breast Neoplasms / genetics. Carcinoma in Situ / genetics. Mutation / genetics
  • [MeSH-minor] Adult. Aged. Carcinoma, Ductal, Breast / genetics. Carcinoma, Ductal, Breast / pathology. Carcinoma, Lobular / genetics. Carcinoma, Lobular / pathology. Carcinoma, Medullary / genetics. Carcinoma, Medullary / pathology. Cross-Sectional Studies. Female. Humans. Middle Aged. Retrospective Studies

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  • [CommentIn] Cancer Prev Res (Phila). 2009 Feb;2(2):100-3 [19174575.001]
  • (PMID = 19174581.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BRCA1 Protein; 0 / BRCA2 Protein
  • [Other-IDs] NLM/ NIHMS660771; NLM/ PMC4520422
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51. Gao LB, Wang JZ, Zeng S: [Cloning, expression and the application of human, rat alcohol dehydrogenase and aldo-keto reductase]. Yao Xue Xue Bao; 2009 Jul;44(7):778-84
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  • This study is aimed to clone and express human, rat alcohol dehydrogenase (ADH) and aldo-keto reductase.
  • MA enantiomers were incubated with rat, human ADH and phenylglyoxylic acid (PGA) with AKR1A1, respectively.

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  • (PMID = 19806920.001).
  • [ISSN] 0513-4870
  • [Journal-full-title] Yao xue xue bao = Acta pharmaceutica Sinica
  • [ISO-abbreviation] Yao Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Recombinant Proteins; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.184 / carbonyl reductase (NADPH); EC 1.1.1.21 / Aldehyde Reductase
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52. Yamashita H, Ishimaru M, Yamaguchi H, Yamauchi H, Sugiura A, Kitayama J, Nagawa H: Massive postoperative polyuria following total gastrectomy for gastric cancer. J Anesth; 2006;20(1):36-9
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  • Several administrations of an antidiuretic hormone (ADH) analogue were ineffective in reducing urine output, suggesting a possible relationship of the massive polyuria to nephrogenic diabetes insipidus.

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  • (PMID = 16421675.001).
  • [ISSN] 0913-8668
  • [Journal-full-title] Journal of anesthesia
  • [ISO-abbreviation] J Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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53. Lu RB, Ko HC, Lee JF, Lin WW, Huang SY, Wang TJ, Wu YS, Lu TE, Chou YH: No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. Alcohol Clin Exp Res; 2005 Dec;29(12):2101-7
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  • Most previous studies, however, have failed to separate the effects of antisocial personality disorder from those of alcoholism because of their high comorbidity.
  • To understand the relationship among alcoholism, antisocial personality disorder, and the protective effects of ADH and ALDH, it is necessary to recruit individuals with antisocial personality disorder but without alcoholism.
  • METHODS: We recruited 579 Han Chinese individuals in Taiwan, intending to examine the alcoholism-protection effects of different ADH1B and ALDH2 genotypes with or without antisocial personality disorder.
  • [MeSH-major] Alcohol Dehydrogenase / genetics. Alcoholism / epidemiology. Alcoholism / genetics. Antisocial Personality Disorder / epidemiology. Antisocial Personality Disorder / genetics

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  • (PMID = 16385179.001).
  • [ISSN] 0145-6008
  • [Journal-full-title] Alcoholism, clinical and experimental research
  • [ISO-abbreviation] Alcohol. Clin. Exp. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA; EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / Aldehyde Dehydrogenase
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54. Zuiani C, Londero V, Bestagno A, Puglisi F, Di Loreto C, Bazzocchi M: Proliferative high-risk lesions of the breast: contribution and limits of US-guided core biopsy. Radiol Med; 2005 Nov-Dec;110(5-6):589-602
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  • [Title] Proliferative high-risk lesions of the breast: contribution and limits of US-guided core biopsy.
  • PURPOSE: To retrospectively correlate high-risk proliferative breast lesions (radial scar, atypical lobular hyperplasia, lobular carcinoma in situ and papillary lesions) diagnosed on core biopsy with the definitive histopathological diagnosis obtained after surgical excision or with the follow-up, in order to assess the role of core biopsy in such lesions.
  • To discuss the management of the patient after a core biopsy diagnosis of high-risk proliferative breast lesion.
  • The histopathologic findings were as follows: 11 radial scars (RS), 3 atypical lobular hyperplasias (ALH), 3 lobular carcinomas in situ (LCIS), 57 benign papillary lesions.
  • All patients underwent bilateral mammography, whole-breast ultrasound with a linear-array broadband transducer, and core biopsy with a 14 Gauge needle and a mean number of samples of 5 (range 4-7).
  • Sixty-two of 67 patients, for a total of 69/74 lesions, underwent surgical biopsy despite benign histopathologic findings, mostly because of highly suspicious imaging for malignancy (BIRADS 4-5), whereas 5 patients refused surgery and have been followed up for a least 18 months and are still being followed up (2 with RS, 1 with ADH and 2 with papillary lesions).
  • RESULTS: Among the core biopsied lesions with a diagnosis of RS (n = 11) pathology revealed one ductal carcinoma in situ (DCIS) (this case was characterized by granular microcalcifications on mammography and by a mass with irregular margins on ultrasound).
  • Also in the group of ADH (n = 3) pathology revealed one DCIS (lesion not visible on mammography but depicted as a suspicious mass on US).
  • Altogether there were 10 false negative results (underestimation) out of 74 core biopsies with a diagnosis of high-risk proliferative breast lesions.
  • CONCLUSION: The high rate of histological underestimation after core biopsy (10/74) (13.5%) demands a very careful management of patents with a core biopsy diagnosis of high-risk proliferative breast lesions, especially in the case of RS, lobular neoplasia and papillary lesions.
  • [MeSH-major] Biopsy / methods. Breast Diseases / pathology

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  • (PMID = 16437044.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
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55. Yalcin-Cakmakli G, Karli Oguz K, Shorbagi A, Funda Bas D, Ergan-Arsava B, Kunt M, Topcuoglu MA: Hyponatremic encephalopathy after excessive water ingestion prior to pelvic ultrasound: neuroimaging findings. Intern Med; 2010;49(16):1807-11
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  • In addition to the first illustration of multimodality MR imaging features of water-intoxication, these two cases also highlight the need for standardized practice on the quantity of water intake recommended to distend the bladder for pelvic ultrasound, especially in patients at risk for serum inappropriate ADH syndrome-related hyponatremia.
  • [MeSH-major] Brain Edema / diagnosis. Hyponatremia / diagnosis. Pelvis / ultrasonography. Water Intoxication / diagnosis

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  • (PMID = 20720364.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Lee SM, Alam R, Ho CJ, Kim JH, Kang CW, Park JH, Lee MS: Involvement of p42/44 MAPK in the effects of ethanol on secretion of insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-1 in primary cultured rat hepatocytes. Int J Neurosci; 2007 Feb;117(2):187-201
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  • In addition, inhibition of p42/44 MAPK activity by ethanol occurs via the activity of ADH.

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  • (PMID = 17365107.001).
  • [ISSN] 0020-7454
  • [Journal-full-title] The International journal of neuroscience
  • [ISO-abbreviation] Int. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Enzyme Inhibitors; 0 / Insulin-Like Growth Factor Binding Protein 1; 3K9958V90M / Ethanol; 67763-96-6 / Insulin-Like Growth Factor I; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
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57. Chiang CP, Wu CW, Lee SP, Chung CC, Wang CW, Lee SL, Nieh S, Yin SJ: Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury. Alcohol Clin Exp Res; 2009 Jun;33(6):1059-68
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  • BACKGROUND: Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are major enzymes responsible for metabolism of ethanol.
  • The goal of this study was to determine the functional expressions and cellular localization of ADH and ALDH families in human pancreas.
  • The isozyme expression patterns of ADH/ALDH were identified by isoelectric focusing, and the activities were assayed spectrophotometrically.
  • The protein contents of ADH/ALDH isozymes were determined by immunoblotting, and the cellular localizations were detected by immunohistochemistry and histochemistry.

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  • (PMID = 19382905.001).
  • [ISSN] 1530-0277
  • [Journal-full-title] Alcoholism, clinical and experimental research
  • [ISO-abbreviation] Alcohol. Clin. Exp. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Isoenzymes; 3K9958V90M / Ethanol; EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / ALDH2 protein, human; EC 1.2.1.3 / Aldehyde Dehydrogenase
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58. Yeom J, Bhang SH, Kim BS, Seo MS, Hwang EJ, Cho IH, Park JK, Hahn SK: Effect of cross-linking reagents for hyaluronic acid hydrogel dermal fillers on tissue augmentation and regeneration. Bioconjug Chem; 2010 Feb 17;21(2):240-7
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  • Five kinds of samples, a normal control, a negative control, a positive control of Restylane, adipic acid dihydrazide grafted HA (HA-ADH) hydrogels, and HA-HMDA hydrogels, were subcutaneously injected to wrinkled model mice.

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  • (PMID = 20078098.001).
  • [ISSN] 1520-4812
  • [Journal-full-title] Bioconjugate chemistry
  • [ISO-abbreviation] Bioconjug. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Cross-Linking Reagents; 0 / Diamines; 0 / Hydrogels; 9004-61-9 / Hyaluronic Acid; 9007-34-5 / Collagen; ZRA5J5B2QW / 1,6-diaminohexane
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59. Dendorfer U, Mann J: [Drug-related disorders of water and electrolyte metabolism]. Internist (Berl); 2006 Nov;47(11):1121-2, 1124-6, 8
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  • Drug-induced disorders of Na+ concentration may usually be attributed to altered antidiuretic hormone (ADH) effects, either as diabetes insipidus or as the syndrome of inappropriate ADH secretion.

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  • (PMID = 16988802.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Antidiuretic Agents; 0 / Antihypertensive Agents; 0 / Gonadal Steroid Hormones
  • [Number-of-references] 24
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60. Chen YY, DeVries S, Anderson J, Lessing J, Swain R, Chin K, Shim V, Esserman LJ, Waldman FM, Hwang ES: Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ. BMC Cancer; 2009 Aug 18;9:285
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  • [Title] Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.
  • BACKGROUND: Endocrine therapy is commonly recommended in the adjuvant setting for patients as treatment for ductal carcinoma in situ (DCIS).
  • Following treatment, predominant morphologic changes included increased multinucleated histiocytes and degenerated cells, decreased duct extension, and prominent periductal fibrosis.
  • Two postmenopausal patients had ADH only with no residual DCIS at excision.
  • [MeSH-major] Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Estrogen Antagonists / therapeutic use. Hormone Replacement Therapy. Receptors, Estrogen / metabolism. Tamoxifen / therapeutic use
  • [MeSH-minor] Adult. Aged. Carcinoma, Ductal. Cohort Studies. Female. Gene Expression Regulation, Neoplastic. Humans. Middle Aged. Nitriles / therapeutic use. Triazoles / therapeutic use

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  • (PMID = 19689789.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00290745
  • [Grant] United States / NCI NIH HHS / CA / K23CA097181; United States / NCI NIH HHS / CA / P50 CA58207
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 0 / Nitriles; 0 / Receptors, Estrogen; 0 / Triazoles; 094ZI81Y45 / Tamoxifen; 7LKK855W8I / letrozole
  • [Other-IDs] NLM/ PMC2744704
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61. Zagouri F, Sergentanis TN, Nonni A, Koulocheri D, Fotou M, Panopoulou E, Panou M, Fotiadis C, Bramis J, Zografos GC: Vacuum-assisted breast biopsy: the value and limitations of cores with microcalcifications. Pathol Res Pract; 2007;203(8):563-6
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  • [Title] Vacuum-assisted breast biopsy: the value and limitations of cores with microcalcifications.
  • The aim of this study was to assess cores with microcalcifications (CM) and without microcalcifications (CWM) obtained from vacuum-assisted breast biopsy (VABB).
  • The study included 12 atypical ductal hyperplasias (ADH), 37 ductal carcinomas in situ (DCIS), and seven invasive ductal carcinomas (IDC) diagnosed by VABB (11G) on the Fischer's table.
  • CWM failed to make the diagnosis in 8.3% and 35.1% of ADH and DCIS, respectively.
  • In 28.6% of IDC, diagnosis was made through CWM.
  • The underestimation rate was 8.3% in ADH, and 10.8% in DCIS.
  • CMs are superior in DCIS/ADH diagnosis.
  • However, CWM may be valuable for the diagnosis of the invasive component.
  • [MeSH-major] Biopsy / methods. Breast Neoplasms / pathology. Breast Neoplasms / surgery. Calcinosis / pathology. Calcinosis / surgery

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  • (PMID = 17611039.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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62. Kristoffersen L, Skuterud B, Larssen BR, Skurtveit S, Smith-Kielland A: Fast quantification of ethanol in whole blood specimens by the enzymatic alcohol dehydrogenase method. Optimization by experimental design. J Anal Toxicol; 2005 Jan-Feb;29(1):66-70
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  • Alcohol dehydrogenase (ADH) oxidizes ethanol to acetaldehyde using the coenzyme nicotinamide adenine dinucleotide (NAD), which is concurrently reduced to form NADH.
  • Method development was performed with the aid of factorial design, varying pH, and concentrations of NAD+ and ADH.

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  • (PMID = 15808017.001).
  • [ISSN] 0146-4760
  • [Journal-full-title] Journal of analytical toxicology
  • [ISO-abbreviation] J Anal Toxicol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; EC 1.1.1.1 / Alcohol Dehydrogenase
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63. Putti TC, Pinder SE, Elston CW, Lee AH, Ellis IO: Breast pathology practice: most common problems in a consultation service. Histopathology; 2005 Nov;47(5):445-57
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  • [Title] Breast pathology practice: most common problems in a consultation service.
  • Considerable progress has been made in understanding breast lesions utilizing molecular methods, but conventional morphology, simple immunohistochemical stains and common sense still prevail in diagnosing the vast majority of breast disease.
  • The focus of this review is to identify the most common breast lesions sent to our consultation practice, and to reiterate salient diagnostic features, differential diagnoses and common pitfalls in identifying these lesions.
  • Separation of epithelial proliferative lesions and differentiation between usual epithelial hyperplasia (UEH) and atypical ductal hyperplasia (ADH) are the most common problems encountered in our Consultation practice.
  • Differentiation between UEH and ADH is based on the assumption that ADH is a clonal process, recognized by a uniform phenotype and more recently described immunohistochemical markers such as differential cytokeratin and also hormone receptor expression.
  • [MeSH-major] Breast Diseases / diagnosis. Mammary Glands, Human / pathology. Referral and Consultation
  • [MeSH-minor] Adult. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma in Situ / diagnosis. Carcinoma in Situ / pathology. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Fibrosis / diagnosis. Fibrosis / pathology. Humans. Hyperplasia / diagnosis. Hyperplasia / pathology. Middle Aged. Neoplasms, Fibroepithelial / diagnosis. Neoplasms, Fibroepithelial / pathology. Papilloma / diagnosis. Papilloma / pathology

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  • (PMID = 16241992.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 43
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64. Guth AA, Shanker BA, Roses DF, Axelrod D, Singh B, Toth H, Shapiro RL, Hiotis K, Diflo T, Cangiarella JF: A decade of change: an institutional experience with breast surgery in 1995 and 2005. Breast Cancer (Auckl); 2008;1:51-5
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  • [Title] A decade of change: an institutional experience with breast surgery in 1995 and 2005.
  • INTRODUCTION: With the adoption of routine screening mammography, breast cancers are being diagnosed at earlier stages, with DCIS now accouting for 22.5% of all newly diagnosed breast cancers.
  • This has been attributed to both increased breast cancer awareness and improvements in breast imaging techniques.
  • How have these changes, including the increased use of image-guided sampling techniques, influenced the clinical practice of breast surgery?
  • METHODS: The institutional pathology database was queried for all breast surgeries, including breast reconstruction, performed in 1995 and 2005.
  • ADH, and to a lesser extent, ALH, became indications for surgical excision.
  • Fewer surgical biopsies were performed for indeterminate abnormalities on breast imaging, due to the introduction of stereotactic large core biopsy.
  • While the rate of benign breast biopsies remained constant, there was a higher percentage of precancerous and DCIS cases in 2005.
  • CONCLUSIONS: While the rate of benign breast biopsies has remained constant over a recent 10-year period, fewer diagnostic surgical image-guided biopsies were performed in 2005.
  • A greater percentage of patients with breast cancer or preinvasive disease have these diagnoses determined before surgery.

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  • (PMID = 21655372.001).
  • [Journal-full-title] Breast cancer : basic and clinical research
  • [ISO-abbreviation] Breast Cancer (Auckl)
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3091402
  • [Keywords] NOTNLM ; breast cancer / breast cancer trends / breast radiology / breast surgery / sentinel nodes
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65. Balasundaram B, Harrison ST: Disruption of Brewers' yeast by hydrodynamic cavitation: Process variables and their influence on selective release. Biotechnol Bioeng; 2006 Jun 5;94(2):303-11
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  • The release profile of the enzymes studied include alpha-glucosidase (periplasmic), invertase (cell wall bound), alcohol dehydrogenase (ADH; cytoplasmic) and glucose-6-phosphate dehydrogenase (G6PDH; cytoplasmic).

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  • [Copyright] Copyright 2006 Wiley Periodicals, Inc.
  • (PMID = 16570316.001).
  • [ISSN] 0006-3592
  • [Journal-full-title] Biotechnology and bioengineering
  • [ISO-abbreviation] Biotechnol. Bioeng.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase; EC 3.2.1.- / Glycoside Hydrolases
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66. Atsumi S, Wu TY, Eckl EM, Hawkins SD, Buelter T, Liao JC: Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes. Appl Microbiol Biotechnol; 2010 Jan;85(3):651-7
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  • Here, we have compared the effect of various alcohol dehydrogenases (ADH) for the last step of the isobutanol production. E. coli has the yqhD gene which encodes a broad-range ADH.
  • The adh genes of two bacteria and one yeast were also compared in E. coli harboring the isobutanol synthesis pathway.

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  • (PMID = 19609521.001).
  • [ISSN] 1432-0614
  • [Journal-full-title] Applied microbiology and biotechnology
  • [ISO-abbreviation] Appl. Microbiol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Butanols; 0 / Escherichia coli Proteins; 0 / Fungal Proteins; 0 / Recombinant Proteins; 56F9Z98TEM / isobutyl alcohol; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.1.1.21 / Aldehyde Reductase
  • [Other-IDs] NLM/ PMC2802489
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67. Yeh IT, Mies C: Application of immunohistochemistry to breast lesions. Arch Pathol Lab Med; 2008 Mar;132(3):349-58
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  • [Title] Application of immunohistochemistry to breast lesions.
  • CONTEXT: Immunohistochemistry has an expanding role in mammary pathology that has been facilitated by a growing list of available antibodies and a better understanding of biology.
  • OBJECTIVE: To explore the key role of immunohistochemistry in guiding adjuvant therapy decisions and sentinel node staging in breast cancer, as well as the role of immunohistochemistry as an aid to distinguishing usual ductal hyperplasia from atypical ductal hyperplasia/low-grade carcinoma in situ; subtyping a carcinoma as ductal or lobular, basal or luminal; ruling out microinvasion in extensive intraductal carcinoma; distinguishing invasive carcinoma from mimics; and establishing that a metastatic carcinoma of unknown primary site has originated in the breast.
  • CONCLUSIONS: As new, targeted treatments for breast cancer are developed, pathologists can expect additional immunohistochemistry applications in the future.
  • [MeSH-major] Biomarkers, Tumor / analysis. Breast Neoplasms / diagnosis. Immunohistochemistry

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  • (PMID = 18318578.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 97
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68. Yang Z, Lu CD: Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa. J Bacteriol; 2007 Jun;189(11):3945-53
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  • While most of the genes involved in arginine uptake, regulation, and metabolism have been identified as members of the ArgR (arginine-responsive regulatory protein) regulon in our previous study, they did not include any genes of the arginine dehydrogenase (ADH) pathway.
  • In this study, 18 putative transcriptional units of 38 genes, including the two known genes of the ADH pathway, kauB and gbuA, were found to be inducible by exogenous L-arginine in the absence of ArgR.
  • To identify the missing genes that encode enzymes for the initial steps of the ADH pathway, the potential physiological functions of those candidate genes in arginine utilization were studied by growth phenotype analysis of knockout mutants.

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 17416670.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Recombinant Fusion Proteins; 94ZLA3W45F / Arginine; EC 2.3.- / Acyltransferases; EC 2.3.1.- / arginine succinyltransferase; EC 2.6.1.- / Transaminases; EC 4.1.1.- / Carboxy-Lyases
  • [Other-IDs] NLM/ PMC1913404
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69. Jelski W, Chrostek L, Laszewicz W, Szmitkowski M: Alcohol dehydrogenase (ADH) isoenzyme activity in the sera of patients with Helicobacter pylori infection. Dig Dis Sci; 2007 Jun;52(6):1513-6
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  • [Title] Alcohol dehydrogenase (ADH) isoenzyme activity in the sera of patients with Helicobacter pylori infection.
  • Human gastric mucosa contains three classes of alcohol dehydrogenase (ADH) isoenzymes: I, III, and IV.
  • Various factors have been found to influence gastric ADH activity.
  • One of them is Helicobacter pylori infection, which is associated with gastric mucosal injury and leads to a decrease in gastric ADH activity.
  • The aim of the study was to assess the effect of H. pylori infection on the serum activity of ADH isoenzymes.
  • The activities of class III and IV ADH isoenzymes were measured by the photometric method with formaldehyde and with m-nitrobenzaldehyde as substrate, respectively.
  • Total activity of ADH was measured by a photometric method with p-nitrosodimethylaniline.
  • The total activities of ADH and class IV isoenzyme were significantly higher in sera of patients with H. pylori infection compared to healthy subjects.
  • The serum activity of other tested isoenzymes of ADH did not differ significantly between infected and noninfected groups.
  • We conclude that H. pylori infection of gastric mucosa is reflected in the serum by a significant increase in class IV and total ADH activity.

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  • (PMID = 17404875.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 1.1.1.1 / Alcohol Dehydrogenase
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70. Peña-Fronteras JT, Villalobos MC, Baltazar AM, Merca FE, Ismail AM, Johnson DE: Adaptation to flooding in upland and lowland ecotypes of Cyperus rotundus, a troublesome sedge weed of rice: tuber morphology and carbohydrate metabolism. Ann Bot; 2009 Jan;103(2):295-302
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  • METHODS: Upland and lowland ecotypes of C. rotundus were compared in terms of growth habit, carbohydrate reserves and metabolism, and activities of enzymes involved in alcoholic fermentation - alcohol dehydrogenase (ADH) and pyruvate decarboxylase (PDC).
  • At 24 h after germination in hypoxic conditions, PDC and ADH activities in the lowland plants increased, before decreasing at 48 h following germination.
  • In contrast, ADH and PDC activities in the upland plants increased from 24 to 48 h after germination.
  • This is coupled with the modulation of ADH and PDC activities during germination, possibly to control the use of carbohydrate reserves and sustain substrate supply in order to avoid starvation and death of seedlings with prolonged flooding.

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  • (PMID = 18515404.001).
  • [ISSN] 1095-8290
  • [Journal-full-title] Annals of botany
  • [ISO-abbreviation] Ann. Bot.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9005-25-8 / Starch; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 3.2.1.- / Amylases; EC 4.1.1.1 / Pyruvate Decarboxylase
  • [Other-IDs] NLM/ PMC2707299
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71. Hanai T, Atsumi S, Liao JC: Engineered synthetic pathway for isopropanol production in Escherichia coli. Appl Environ Microbiol; 2007 Dec;73(24):7814-8
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  • The strain with the combination of C. acetobutylicum thl (acetyl-coenzyme A [CoA] acetyltransferase), E. coli atoAD (acetoacetyl-CoA transferase), C. acetobutylicum adc (acetoacetate decarboxylase), and C. beijerinckii adh (secondary alcohol dehydrogenase) achieved the highest titer.

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  • (PMID = 17933911.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.1.80 / isopropanol dehydrogenase (NADP); EC 2.3.1.9 / Acetyl-CoA C-Acetyltransferase; EC 4.1.1.- / Carboxy-Lyases; EC 4.1.1.4 / acetoacetate decarboxylase; ND2M416302 / 2-Propanol
  • [Other-IDs] NLM/ PMC2168132
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72. Campbell CT: Transition metal oxides: extra thermodynamic stability as thin films. Phys Rev Lett; 2006 Feb 17;96(6):066106
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  • The adhesion energy at this interface (E(adh,ox/m)) provides extra stabilization, which lowers the O2 pressure required for oxide stability as a thin film below that required for bulk-oxide stability by the factor exp[(2gamma(g/ox) - E(adh,ox/m))/(tN(ox)RT)], where gamma(g/ox) is the surface energy of the oxide, t is the oxide film thickness, and N(ox) is the oxygen concentration in the bulk oxide (moles O2 per volume).

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  • (PMID = 16606017.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. Lührs AK, Guhr S, Schilke R, Borchers L, Geurtsen W, Günay H: Shear bond strength of self-etch adhesives to enamel with additional phosphoric acid etching. Oper Dent; 2008 Mar-Apr;33(2):155-62
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  • In half of each test group, ground enamel surfaces were coated with the self-etch adhesives AdheSe (ADH), Xeno III (XE) or Futurabond NR (FNR).

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  • (PMID = 18435189.001).
  • [ISSN] 0361-7734
  • [Journal-full-title] Operative dentistry
  • [ISO-abbreviation] Oper Dent
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / AdheSE cement; 0 / CeramX; 0 / Composite Resins; 0 / Dentin-Bonding Agents; 0 / Methacrylates; 0 / Phosphoric Acids; 0 / Resin Cements; 0 / Syntac dentine adhesive; 0 / Tetric EvoCeram; 0 / Xeno III; 0 / futurabond NR; 059QF0KO0R / Water; E4GA8884NN / phosphoric acid
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74. Sasano H, Miki Y, Shibuya R, Suzuki T: Aromatase and in situ estrogen production in DCIS (ductal carcinoma in situ) of human breast. J Steroid Biochem Mol Biol; 2010 Feb 28;118(4-5):242-5
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  • [Title] Aromatase and in situ estrogen production in DCIS (ductal carcinoma in situ) of human breast.
  • Ductal carcinoma in situ or DCIS belongs to intraductal proliferative lesions, which are a group of cytologically and architecturally diverse ductal proliferations, typically originating from the terminal duct-lobular units.
  • In these intraductal proliferative diseases, estrogens are considered to be involved in the progression of the disease especially from ductal non-neoplastic hyperplasia to DCIS and possibly development of invasive carcinoma from DCIS.
  • Estrogen receptor (ER) alpha is abundantly expressed in atypical ductal hyperplasia and low grade DCIS.
  • Intratumoral estrogen concentration in DCIS determined by liquid chromatography/electrospray tandem mass spectrometry is significantly higher than that in non-neoplastic breast tissues with statistically not lower than that in invasive carcinoma.
  • Aromatase mRNA expression in both stromal and parenchymal cells of DCIS determined by quantitative RT-PCR following laser capture microdissection was also much higher than that in non-neoplastic breast, although lower than that in invasive carcinoma.
  • Aromatase is overexpressed in noninvasive breast malignancies including DCIS and results in elevated concentrations of intratumoral estradiol.
  • [MeSH-major] Aromatase / metabolism. Carcinoma, Ductal / enzymology. Carcinoma, Ductal, Breast / enzymology. Estrogens / metabolism

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19782135.001).
  • [ISSN] 1879-1220
  • [Journal-full-title] The Journal of steroid biochemistry and molecular biology
  • [ISO-abbreviation] J. Steroid Biochem. Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogens; EC 1.14.14.1 / Aromatase
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75. Graesslin O, Antoine M, Chopier J, Seror JY, Flahault A, Callard P, Daraï E, Uzan S: Histology after lumpectomy in women with epithelial atypia on stereotactic vacuum-assisted breast biopsy. Eur J Surg Oncol; 2010 Feb;36(2):170-5
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  • [Title] Histology after lumpectomy in women with epithelial atypia on stereotactic vacuum-assisted breast biopsy.
  • BACKGROUND: Large-core needle biopsy of the breast (LCNB) and vacuum-assisted breast biopsy (VABB) are widely used as alternatives to open surgical biopsy (OSB) for initial diagnosis of mammographic abnormalities.
  • Between 18% and 80% of cases in which such specimens show atypical lobular hyperplasia (ALH) or atypical ductal hyperplasia (ADH) are found to be malignant at surgery.
  • DESIGN: From 1999 to 2005, 68 women with mammographic abnormalities were sampled by stereotactic VABB and presented atypical epithelial hyperplasia.
  • RESULTS: VABB initially showed 28 cases of ADH, 32 cases of ALH, one case of flat epithelial atypia, five cases of mixed atypia, and two cases of Lobular Carcinoma In Situ (LCIS).
  • After slide review with immunohistochemical staining, two cases of ADH were reclassified as simple hyperplasia and two cases of ALH were reclassified as mixed atypia.
  • Seven lesions (10.3%) that appeared to be benign on VABB were found to be malignant on OSB (Ductal Carcinoma In Situ (DCIS) in six cases and invasive ductal carcinoma in one case).
  • ADH was the only predictive factor of malignancy on OSB (p=0.04 versus ALH).
  • CONCLUSION: ADH diagnosed by vacuum-assisted breast biopsy frequently corresponds to cancer on open surgical biopsy.
  • Surgical excision of all breast lesions containing atypical hyperplasia on percutaneous biopsy can be recommended.
  • [MeSH-major] Biopsy, Needle. Breast Neoplasms / pathology. Mastectomy, Segmental
  • [MeSH-minor] Adult. Aged. Cadherins / analysis. Epithelium / pathology. Female. Humans. Hyperplasia. Immunohistochemistry. Keratin-5 / analysis. Keratin-6 / analysis. Middle Aged. Stereotaxic Techniques

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19811884.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Keratin-5; 0 / Keratin-6
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76. Rao R, Zhang MZ, Zhao M, Cai H, Harris RC, Breyer MD, Hao CM: Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol; 2005 Apr;288(4):F642-9
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  • Lithium also induced renal medullary COX2 protein expression in congenitally polyuric antidiuretic hormone (AHD)-deficient rats, demonstrating that lithium-induced COX2 protein expression is not secondary to altered ADH levels or polyuria.

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  • (PMID = 15585669.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / 2P50-DK-39261; United States / NIDDK NIH HHS / DK / DK-065024
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 1.14.99.1 / Ptgs1 protein, mouse; EC 1.14.99.1 / Ptgs1 protein, rat; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3; G4962QA067 / Lithium Chloride; K7Q1JQR04M / Dinoprostone
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77. Crichton PG, Affourtit C, Moore AL: Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism. Biochem J; 2007 Jan 15;401(2):459-64
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  • In the present study we have shown that mitochondria isolated from Schizosaccharomyces pombe exhibit antimycin A-sensitive oxygen uptake activity that is exclusively dependent on ethanol and is inhibited by trifluoroethanol, a potent inhibitor of ADH (alcohol dehydrogenase).
  • Ethanol-dependent respiratory activity has, to our knowledge, not been reported in S. pombe mitochondria to date, which is surprising as it has been concluded previously that only one ADH gene, encoding a cytosolic enzyme, occurs in this yeast.
  • Spectrophotometric enzyme assays reveal that ADH activity in isolated mitochondria is increased approximately 16-fold by Triton X-100, which demonstrates that the enzyme is located in the matrix.
  • Using genetic knockouts, we show conclusively that the novel mitochondrial ADH is encoded by adh4 and, as such, is unrelated to ADH isoenzymes found in mitochondria of other yeasts.

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  • (PMID = 16999687.001).
  • [ISSN] 1470-8728
  • [Journal-full-title] The Biochemical journal
  • [ISO-abbreviation] Biochem. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isoenzymes; EC 1.1.1.1 / Alcohol Dehydrogenase
  • [Other-IDs] NLM/ PMC1820810
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78. Powers RH, Dean DE: Evaluation of potential lactate/lactate dehydrogenase interference with an enzymatic alcohol analysis. J Anal Toxicol; 2009 Oct;33(8):561-3
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  • The Connecticut Department of Public Safety laboratory recently addressed a legal challenge to a hospital alcohol dehydrogenase (ADH)-based serum ethanol determination based on the suggestion of interference by lactate dehydrogenase (LDH)-catalyzed oxidation of lactate.
  • Both ADH- and LDH-oxidations require NAD(+) (present in excess in the assay).
  • Calculation of the amount of LDH and ADH present in the ethanol assay suggest an ADH/LDH ratio of 200:1.

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  • (PMID = 19874670.001).
  • [ISSN] 1945-2403
  • [Journal-full-title] Journal of analytical toxicology
  • [ISO-abbreviation] J Anal Toxicol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Reagent Kits, Diagnostic; 33X04XA5AT / Lactic Acid; 3K9958V90M / Ethanol; EC 1.1.- / Lactate Dehydrogenases; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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79. Kazakov DV, Suster S, LeBoit PE, Calonje E, Bisceglia M, Kutzner H, Rütten A, Mentzel T, Schaller J, Zelger B, Baltaci M, Leivo I, Rose C, Fukunaga M, Simpson RH, Yang Y, Carlson JA, Cavazza A, Hes O, Mukensnabl P, Vanecek T, Fidalgo A, Pizinger K, Michal M: Mucinous carcinoma of the skin, primary, and secondary: a clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: homologies with mucinous lesions in the breast. Am J Surg Pathol; 2005 Jun;29(6):764-82
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  • [Title] Mucinous carcinoma of the skin, primary, and secondary: a clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: homologies with mucinous lesions in the breast.
  • Our aim was fully to characterize the clinicopathologic spectrum and compare it with that seen in the breast.
  • We demonstrate that primary cutaneous mucinous carcinomas span a morphologic spectrum compatible to their mammary counterparts.
  • Most lesions seem to originate from in situ lesions that may represent, using mammary pathology terminology, ductal hyperplasia, atypical ductal hyperplasia, or ductal carcinoma in situ or a combination of the three.
  • Inverse cell polarity appears to facilitate the progression of the changes similar to lesions in the breast.
  • The presence of an in situ component defines the neoplasm as primary cutaneous, but its absence does not exclude the diagnosis; although for such neoplasms, full clinical assessment is essential.
  • Mammary mucinous carcinoma involving the skin: all patients presented with lesions on chest wall, breast, axilla, and these locations can serve as clue to the breast origin.
  • Microscopically, cutaneous lesions were of both pure and mixed type, and this correlated with the primary in the breast.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Breast Neoplasms / pathology. Intestinal Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast Neoplasms, Male / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 15897743.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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80. Montjoy CA, Rahman A, Teba L: Ethylene glycol and methanol poisonings: case series and review. W V Med J; 2010 Sep-Oct;106(6):17-23
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  • MATERIALS AND METHODS: A retrospective chart review of all adult patients admitted to our institution with a diagnosis of EG or MTH intoxication during a 15-year period was done.
  • Age, sex, EG and MTH levels, degree of acidosis, initial anion and osmolar gaps, renal dysfunction, length of stay in the hospital, need for dialysis, and ADH (alcohol dehydrogenase) blockade treatment were recorded.
  • One must rely on laboratory data for clues in making a diagnosis of intoxication.
  • [MeSH-minor] Acidosis / diagnosis. Adult. Female. Humans. Male. Middle Aged. Poisoning / diagnosis. Poisoning / physiopathology. Retrospective Studies

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  • (PMID = 21928557.001).
  • [ISSN] 0043-3284
  • [Journal-full-title] The West Virginia medical journal
  • [ISO-abbreviation] W V Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Solvents; FC72KVT52F / Ethylene Glycol; Y4S76JWI15 / Methanol
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81. Larriba MJ, Valle N, Pálmer HG, Ordóñez-Morán P, Alvarez-Díaz S, Becker KF, Gamallo C, de Herreros AG, González-Sancho JM, Muñoz A: The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. Endocr Relat Cancer; 2007 Mar;14(1):141-51
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  • The transcription factor Snail1 represses VDR expression and we demonstrate here that Snail1 also abolishes the nuclear export of beta-catenin induced by 1,25(OH)(2)D(3) in SW480-ADH cells.

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  • (PMID = 17395983.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Microfilament Proteins; 0 / Neuropeptides; 0 / Nuclear Proteins; 0 / Receptors, Calcitriol; 0 / Transcription Factors; 0 / Wnt Proteins; 0 / beta Catenin; 0 / dihydroxy-vitamin D3; 0 / ectodermal-neural cortex 1 protein; 0 / snail family transcription factors; 1406-16-2 / Vitamin D; FXC9231JVH / Calcitriol; Q0OZ0D9223 / seocalcitol
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82. Toyama H, Chen ZW, Fukumoto M, Adachi O, Matsushita K, Mathews FS: Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5. J Mol Biol; 2005 Sep 9;352(1):91-104
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  • [Title] Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5.
  • Depending on the alcohols used as growth substrates, Pseudomonas putida HK5 produces two distinct quinohemoprotein alcohol dehydrogenases, ADH-IIB and ADH-IIG, both of which contain pyrroloquinoline quinone (PQQ) and heme c as the prosthetic groups but show different substrate specificities, especially for diol substrates.
  • Molecular cloning of the gene of ADH-IIB and its crystal structure are already reported.
  • Here, molecular cloning of the gene, qgdA, and solution of the three-dimensional structure of ADH-IIG are reported.
  • The crystal structure of ADH-IIG, determined at 2.2A resolution, shows that the overall structure and the amino acid residues involved in PQQ binding are quite similar to ADH-IIB and to another quinohemoprotein ADH, qhEDH from Comamonas testosteroni.
  • Apart from ADH-IIB and qhEDH, ADH-IIG has an extra 12-residue helix within loop 3 in the PQQ domain and an extra 3(10) helix in the C terminus of the cytochrome domain, and both helices appear parallel and linked by a hydrogen bond.
  • In the crystal structure of ADH-IIG with 1,2-propanediol, one of the hydroxyl groups of the substrate forms a hydrogen bond with O5 of PQQ and OD1 of Asp300, and the other interacts with a water molecule and with NE2 of Trp386, the corresponding residue of which is not found in ADH-IIB and qhEDH, and might be the residue responsible for making ADH-IIG prefer diol substrates.

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  • (PMID = 16061256.001).
  • [ISSN] 0022-2836
  • [Journal-full-title] Journal of molecular biology
  • [ISO-abbreviation] J. Mol. Biol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AB204833
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Isoenzymes; 9007-43-6 / Cytochromes c; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.2.8 / alcohol dehydrogenase (acceptor)
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83. Edenberg HJ, Xuei X, Chen HJ, Tian H, Wetherill LF, Dick DM, Almasy L, Bierut L, Bucholz KK, Goate A, Hesselbrock V, Kuperman S, Nurnberger J, Porjesz B, Rice J, Schuckit M, Tischfield J, Begleiter H, Foroud T: Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet; 2006 May 1;15(9):1539-49
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  • Linkage evidence indicated that gene(s) located on chromosome 4q, in the region of the alcohol dehydrogenase (ADH) genes, affected risk for alcoholism.
  • We genotyped 110 single nucleotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism in a set of families with multiple alcoholic members, using the pedigree disequilibrium test.

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  • (PMID = 16571603.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / U10AA008401
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
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84. Mossé IB, Mikhaĭlova ME, Glushkova IV, Kasinskaia SI, Anoshenko IP, Aksiutik TV, Tikhanovich NI, Kamysh NA: [Genetic monitoring of natural Drosophila populations in radiation contaminated regions of Belarus]. Radiats Biol Radioecol; 2006 May-Jun;46(3):287-95
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  • The dominant and recessive lethal mutation levels and genetic structure of the populations were analyzed for frequencies of F- and S-alleles of Adh (alcohol dehydrogenase) of Gpdh (glycerinophosphate dehydrogenase) and Sod (superoxide dismutase) loci.

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  • (PMID = 16869160.001).
  • [ISSN] 0869-8031
  • [Journal-full-title] Radiatsionnaia biologiia, radioecologiia
  • [ISO-abbreviation] Radiats Biol Radioecol
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Drosophila Proteins; 0 / Radioactive Pollutants; EC 1.1.- / Alcohol Oxidoreductases; EC 1.1.- / Glycerolphosphate Dehydrogenase; EC 1.1.1.1 / ADH protein, Drosophila; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.15.1.1 / Superoxide Dismutase
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85. Lutz P, Maring D, Tschampa HJ, Sauerbruch T: [A 25-year-old patient with colonic pseudo-obstruction, hyponatremia, hypertension, and diffuse pain]. Med Klin (Munich); 2010 Apr;105(4):267-72
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  • Shortly after admission, she developed generalized seizures while hyponatremia increased compatible with SIADH (syndrome of inadequate ADH secretion).
  • Since porphobilinogen deaminase activity was clearly decreased, diagnosis of acute intermittent porphyria could be confirmed.
  • CONCLUSION: This case shows how definite diagnosis of this illness is often delayed because of its rarity and the variety of its possible symptoms and signs.
  • [MeSH-major] Colonic Pseudo-Obstruction / etiology. Hypertension / etiology. Hyponatremia / etiology. Pain / etiology. Porphyria, Acute Intermittent / diagnosis
  • [MeSH-minor] Adult. Delayed Diagnosis. Diagnosis, Differential. Epilepsy, Generalized / etiology. Female. Humans. Hydroxymethylbilane Synthase. Inappropriate ADH Syndrome / diagnosis

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  • (PMID = 20455047.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.5.1.61 / Hydroxymethylbilane Synthase
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86. Wiratkapun C, Wibulpholprasert B, Wongwaisayawan S, Pulpinyo K: Nondiagnostic core needle biopsy of the breast under imaging guidance: result of rebiopsy. J Med Assoc Thai; 2005 Mar;88(3):350-7
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  • [Title] Nondiagnostic core needle biopsy of the breast under imaging guidance: result of rebiopsy.
  • MATERIAL AND METHOD: A retrospective review was performed in 1,306 consecutive women who underwent core needle biopsy under imaging guidance at the breast diagnostic center, the Faculty of Medicine, Ramathibodi Hospital from October 1997 to March 2004.
  • The three most common reasons for recommendation of rebiopsy were discordant imaging and pathology, atypical ductal hyperplasia and inadequate specimen.
  • [MeSH-major] Biopsy, Needle / methods. Breast / pathology. Breast Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Breast Diseases / pathology. Female. Humans. Middle Aged. Reoperation. Retrospective Studies

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  • (PMID = 15962643.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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87. Guo Y, Wu XQ, Zhang C, Liao ZX, Wu Y, Xia ZY, Wang H: Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices. Clin Exp Pharmacol Physiol; 2010 Dec;37(12):1107-13
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  • In I3C groups, cytochrome P450 (CYP) 2E1 activities were inhibited by 40.9-51.8%, whereas alcohol dehydrogenase (ADH) activity was enhanced 1.6-fold compared with the ethanol-treated group.

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  • [Copyright] © 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd.
  • [CommentIn] Clin Exp Pharmacol Physiol. 2012 Jul;39(7):642 [22738366.001]
  • (PMID = 20880187.001).
  • [ISSN] 1440-1681
  • [Journal-full-title] Clinical and experimental pharmacology & physiology
  • [ISO-abbreviation] Clin. Exp. Pharmacol. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Actins; 0 / Indoles; 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / Transforming Growth Factor beta1; 0 / smooth muscle actin, rat; 3K9958V90M / Ethanol; 9007-34-5 / Collagen; C11E72455F / indole-3-carbinol; EC 3.4.24.7 / Matrix Metalloproteinase 1; GO1N1ZPR3B / Acetaldehyde
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88. Lysak MA, Koch MA, Beaulieu JM, Meister A, Leitch IJ: The dynamic ups and downs of genome size evolution in Brassicaceae. Mol Biol Evol; 2009 Jan;26(1):85-98
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  • Evolution of GS was analyzed within a phylogenetic framework based on gene trees built from five data sets (matK, chs, adh, trnLF, and ITS).

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  • (PMID = 18842687.001).
  • [ISSN] 1537-1719
  • [Journal-full-title] Molecular biology and evolution
  • [ISO-abbreviation] Mol. Biol. Evol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Robinson D: Nocturia in women. Int J Clin Pract Suppl; 2007 Sep;(155):23-31
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  • When evaluating women complaining of nocturia a urinary diary and clinical examination is integral to making the diagnosis prior to commencing treatment.
  • Should this conservative approach fail then treatment with antimuscarinic agents or desmopressin, a nona-peptide analogue of anti-diuretic hormone (ADH) is often helpful.

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  • (PMID = 17727576.001).
  • [ISSN] 1368-504X
  • [Journal-full-title] International journal of clinical practice. Supplement
  • [ISO-abbreviation] Int J Clin Pract Suppl
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 58
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90. Thompson CE, Fernandes CL, de Souza ON, de Freitas LB, Salzano FM: Evaluation of the impact of functional diversification on Poaceae, Brassicaceae, Fabaceae, and Pinaceae alcohol dehydrogenase enzymes. J Mol Model; 2010 May;16(5):919-28
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  • Several studies point to functional diversification of the ADH, with evidence of its importance, in different organisms, in the ethanol, norepinephrine, dopamine, serotonin, and bile acid metabolism.
  • The main objective of this article is to establish a correlation between the functional diversification occurring in the plant alcohol dehydrogenase family and the three-dimensional structures predicted for 17 ADH belonging to Poaceae, Brassicaceae, Fabaceae, and Pinaceae botanical families.

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  • (PMID = 19834749.001).
  • [ISSN] 0948-5023
  • [Journal-full-title] Journal of molecular modeling
  • [ISO-abbreviation] J Mol Model
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase
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91. Emerson RO, Sage EH, Ghosh JG, Clark JI: Chaperone-like activity revealed in the matricellular protein SPARC. J Cell Biochem; 2006 Jul 1;98(4):701-5
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  • Unfolding and aggregation of the chaperone target protein, alcohol dehydrogenase (ADH), were initiated at 50 degrees C.
  • SPARC inhibited the thermal aggregation of ADH in a concentration-dependent manner, with maximal inhibition at a 1:4 molar ratio of SPARC:ADH.

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16598771.001).
  • [ISSN] 0730-2312
  • [Journal-full-title] Journal of cellular biochemistry
  • [ISO-abbreviation] J. Cell. Biochem.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY004542; United States / NEI NIH HHS / EY / EY13180; United States / NIGMS NIH HHS / GM / GM40711
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Molecular Chaperones; 0 / Osteonectin; 0 / alpha-Crystallins; 0 / beta-Crystallins; EC 1.1.1.1 / Alcohol Dehydrogenase
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92. Birley AJ, Whitfield JB, Neale MC, Duffy DL, Heath AC, Boomsma DI, Martin NG: Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. Behav Genet; 2005 Sep;35(5):509-24
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  • Nearly all participants were subsequently genotyped on two polymorphic SNPs in the ADH1B and ADH1C loci known to affect in vitro ADH activity.
  • In the DZ pairs, 14 microsatellite markers covering a 20.5 cM region on chromosome 4 that includes the ADH gene family were assessed, Variation in the timed series of autocorrelated blood and breath alcohol readings was studied using a bivariate simplex design.
  • The contribution of a quantitative trait locus (QTL) or QTL's linked to the ADH region was estimated via a mixture of likelihoods weighted by identity-by-descent probabilities.
  • This implies that there is a major determinant of variation for in vivo alcohol metabolism in the ADH region that is not accounted for by these polymorphisms.

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  • (PMID = 16184481.001).
  • [ISSN] 0001-8244
  • [Journal-full-title] Behavior genetics
  • [ISO-abbreviation] Behav. Genet.
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / AA013321; United States / NIAAA NIH HHS / AA / AA013326; United States / NIAAA NIH HHS / AA / AA014041; United States / NIAAA NIH HHS / AA / AA077281; United States / NIMH NIH HHS / MH / MH-65322
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; EC 1.1.1.1 / ADH1B protein, human; EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase
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93. Fukuhara K, Omura T, Katsuragi K, Osugi H, Lee S, Kishida S: [A case of severe electrolytic disorder after adjuvant chemotherapy for esophageal cancer]. Gan To Kagaku Ryoho; 2009 Aug;36(8):1359-61
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  • [Title] [A case of severe electrolytic disorder after adjuvant chemotherapy for esophageal cancer].
  • An electrolytic disorder was found on day 2, and her consciousness became unclear on 5 day (respective Na, K and Cl values of 113, 2.2 and 67 mEq/L in blood).
  • As the b2-microglobulin level was high in urine and the ADH level in blood was normal, cisplatinum nephrotoxicity was thought to make this accident.
  • Electrolytes should be checked carefully for disorder during chemotherapy.


94. Ichihara S, Fujimoto T, Hashimoto K, Moritani S, Hasegawa M, Yokoi T: Double immunostaining with p63 and high-molecular-weight cytokeratins distinguishes borderline papillary lesions of the breast. Pathol Int; 2007 Mar;57(3):126-32
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  • [Title] Double immunostaining with p63 and high-molecular-weight cytokeratins distinguishes borderline papillary lesions of the breast.
  • Papillary breast lesions remain a source of diagnostic confusion because the full range of epithelial proliferations may arise within, or secondarily involve, papilloma.
  • The expression of p63 and high-molecular-weight cytokeratins (HMWCK) was studied simultaneously in 33 papillary lesions including intraductal papilloma (IP, n = 10), atypical papilloma (AP, n = 8) and intraductal papillary carcinoma (IPC, n = 15) by double immunostaining.
  • The myoepithelial cell nuclei were stained dark brown whereas the cytoplasms of usual ductal hyperplasia (UDH) and myoepithelium were stained purple.
  • The present data suggest that the double immunostaining with the two popular antibodies p63 and HMWCK is a useful tool for reproducible classification of papillary breast lesions.
  • [MeSH-major] Breast Neoplasms / metabolism. Carcinoma, Papillary / metabolism. DNA-Binding Proteins / metabolism. Keratins / metabolism. Mammary Glands, Human / metabolism. Papilloma, Intraductal / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / pathology. Female. Fluorescent Antibody Technique, Direct. Humans. Hyperplasia / metabolism. Hyperplasia / pathology. Immunoenzyme Techniques. Middle Aged. Molecular Weight. Retrospective Studies. Transcription Factors

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  • (PMID = 17295644.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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95. Zhang L, Xu Z, Sun X, Dong S: A novel alcohol dehydrogenase biosensor based on solid-state electrogenerated chemiluminescence by assembling dehydrogenase to Ru(bpy)(3)2+-Au nanoparticles aggregates. Biosens Bioelectron; 2007 Jan 15;22(6):1097-100
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  • Based on electrogenerated chemiluminescence (ECL), a novel method for fabrication of alcohol dehydrogenase (ADH) biosensor by self-assembling ADH to Ru(bpy)(3)(2+)-AuNPs aggregates (Ru-AuNPs) on indium tin oxide (ITO) electrode surface has been developed.

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  • (PMID = 16815003.001).
  • [ISSN] 0956-5663
  • [Journal-full-title] Biosensors & bioelectronics
  • [ISO-abbreviation] Biosens Bioelectron
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzymes, Immobilized; 3K9958V90M / Ethanol; 7440-57-5 / Gold; EC 1.1.1.1 / Alcohol Dehydrogenase; MLT4718TJW / Rubidium
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96. Moncrief RM, Nayar R, Diaz LK, Staradub VL, Morrow M, Khan SA: A comparison of ductoscopy-guided and conventional surgical excision in women with spontaneous nipple discharge. Ann Surg; 2005 Apr;241(4):575-81
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  • INTRODUCTION: Radiologic imaging is routinely used to evaluate women with spontaneous nipple discharge (SND), but definitive diagnosis is usually only achieved by surgical terminal duct excision (TDE).
  • MATERIALS AND METHODS: We conducted a retrospective review of the records of 117 consecutive women who underwent ductoscopy to guide ductal excision (scope-DE) or received conventional TDE without ductoscopy.
  • Two women had atypical ductal lavage cytology and the remainder presented with SND from 1 or more duct.
  • RESULTS: Fifty-nine women underwent scope-DE, and 58 underwent conventional TDE.
  • The proportion of women with intraductal neoplasia was slightly greater in the group undergoing scope-DE (88% vs. 81%, P = 0.2).
  • In the conventional TDE group, 8.5% were found to have atypical hyperplasia or duct carcinoma in situ compared with 18.6% in the scope-DE group.

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  • (PMID = 15798458.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA089018; United States / NCI NIH HHS / CA / P50 CA89018
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1357060
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97. Renshaw AA, Derhagopian RP, Martinez P, Gould EW: Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision. Am J Clin Pathol; 2006 Aug;126(2):310-3
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  • [Title] Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision.
  • To address the significance of lobular neoplasia (LN) in breast core needle biopsy specimens, we prospectively obtained LN cases and correlated results of subsequent tissue sampling.
  • LN was diagnosed by core needle biopsy in 467 women; in 101 (21.6%), invasive carcinoma (IC) or ductal carcinoma in situ (DCIS) was diagnosed concurrently.
  • Two patients (0.4%) had previous diagnoses of IC or DCIS, and 17 (3.6%) had a concurrent diagnosis of contralateral IC or DCIS.
  • Of 366 patients without a concurrent diagnosis of IC or DCIS, subsequent tissue diagnoses were available for 156 cases (42.6%).
  • Of 60 cases of LN and atypical ductal hyperplasia on the biopsy, 5 had IC and 10 had DCIS on the excision (total, 25%).
  • [MeSH-major] Biopsy, Needle. Breast / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Lobular / pathology


98. Wills SM, Zekman R, Bestul D, Kuwajerwala N, Decker D: Tamoxifen malabsorption after Roux-en-Y gastric bypass surgery: case series and review of the literature. Pharmacotherapy; 2010 Feb;30(2):217
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  • Two years later, she developed estrogen receptor-positive ductal carcinoma in situ of the breast, underwent lumpectomy and irradiation, and tamoxifen was started.
  • The second patient was a 51-year-old woman who sought medical advice on risk reduction for breast cancer after receiving a diagnosis of atypical ductal hyperplasia of the breast.
  • Tamoxifen was started to reduce her risk of breast cancer; her plasma tamoxifen level was subtherapeutic at 14 ng/ml.
  • The third patient was a 53-year-old woman with estrogen receptor-positive breast cancer who underwent lumpectomy and was prescribed anastrozole, an aromatase inhibitor.

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  • (PMID = 20099995.001).
  • [ISSN] 1875-9114
  • [Journal-full-title] Pharmacotherapy
  • [ISO-abbreviation] Pharmacotherapy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen
  • [Number-of-references] 30
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99. Monkenbusch M, Richter D, Biehl R: Observation of protein domain motions by neutron spectroscopy. Chemphyschem; 2010 Apr 26;11(6):1188-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The NSE experiment on alcohol dehydrogenase (ADH) is used as example to illustrate the general principles of the method.

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  • (PMID = 19924753.001).
  • [ISSN] 1439-7641
  • [Journal-full-title] Chemphyschem : a European journal of chemical physics and physical chemistry
  • [ISO-abbreviation] Chemphyschem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0U46U6E8UK / NAD; EC 1.1.1.1 / Alcohol Dehydrogenase
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100. Emery LA, Tripathi A, King C, Kavanah M, Mendez J, Stone MD, de las Morenas A, Sebastiani P, Rosenberg CL: Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression. Am J Pathol; 2009 Sep;175(3):1292-302
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression.
  • Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer.
  • To better understand the relationship of breast lesions to more advanced disease, we used microdissection and DNA microarrays to profile the gene expression of patient-matched histologically normal (HN), ADH, and DCIS from 12 patients with estrogen receptor positive sporadic breast cancer.
  • We found 837 differentially expressed genes between DCIS-HN and 447 between ADH-HN, with >90% of the ADH-HN genes also present among the DCIS-HN genes.
  • Only 61 genes were identified between ADH-DCIS.
  • Many breast cancer-related genes and pathways were dysregulated in ADH and maintained in DCIS.
  • We conclude that ADH and DCIS share highly similar gene expression and are distinct from HN.
  • These data provide genetic evidence that ADH (but not SH) are often precursors to cancer and suggest cancer-related genetic changes, particularly adhesion and extracellular matrix pathways, are dysregulated before invasion and even before malignancy is apparent.