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1. Kelly TG, Shattuck TM, Reyes-Mugica M, Stewart AF, Simonds WF, Udelsman R, Arnold A, Carpenter TO: Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. J Bone Miner Res; 2006 Oct;21(10):1666-71
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  • [Title] Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation.
  • Histologic features typical of a benign adenoma were evident after surgical extirpation of the gland.
  • He was found to have a PT adenoma with aggressive features.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma / diagnosis. Germ-Line Mutation. Hyperparathyroidism, Primary / genetics. Parathyroid Neoplasms / diagnosis. Tumor Suppressor Proteins / genetics

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  • (PMID = 16995822.001).
  • [ISSN] 0884-0431
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K24-HD01288; United States / NCRR NIH HHS / RR / M01-RR000125
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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2. Fernandez-Ranvier GG, Khanafshar E, Jensen K, Zarnegar R, Lee J, Kebebew E, Duh QY, Clark OH: Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis? Cancer; 2007 Jul 15;110(2):255-64
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  • [Title] Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?
  • BACKGROUND: Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical parathyroid adenomas, but distinguishing them from each other is more difficult.
  • METHODS: A retrospective study of 28 consecutive patients with parathyroid carcinoma, 7 patients with atypical parathyroid adenoma, and 13 patients with parathyromatosis who were treated at the University of California at San Francisco Medical Center between 1966 and 2005 was performed.
  • RESULTS: Parathyroid carcinoma (19 of 28 patients) and atypical adenoma (4 of 7 patients) were significantly more common in men, whereas parathyromatosis was more common in women (10 of 13 patients) (P = .02).
  • Prior to the first parathyroid surgery, patients with parathyroid carcinoma were found to have higher blood calcium levels (>/=14 mg/dL in 16 of 26 patients [62%]), whereas only 1 of 6 patients with atypical adenoma (17%) and no patients with parathyromatosis were found to have profound hypercalcemia (P < .01).
  • Intraoperatively, patients with parathyroid carcinoma and atypical adenoma presented with single lesions, whereas patients with parathyromatosis had multiple small lesions.
  • CONCLUSIONS: Patients with parathyroid carcinoma often differ from those with atypical parathyroid adenoma or parathyromatosis at the time of presentation because patients with parathyroid carcinoma have more profound hypercalcemia as well as invasive tumors.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Hyperparathyroidism / pathology. Parathyroid Neoplasms / pathology

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  • (PMID = 17559137.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Cetani F, Pardi E, Ambrogini E, Banti C, Viacava P, Borsari S, Bilezikian JP, Pinchera A, Marcocci C: Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment. J Endocrinol Invest; 2008 Oct;31(10):900-4
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  • HRPT2 and parafibromin studies improved the diagnostic accuracy in two patients with primary hyperparathyroidism (PHPT) referred to us after surgery, in whom the clinical data were at variance with the pathological diagnosis of adenoma and carcinoma, respectively.
  • Patient #2, with severe PHPT, had had the removal of a 3.5-cm tumor described histologically as adenoma.
  • Re-review of the initial histology showed a trabecular pattern, fibrous bands, and atypical mitoses, suggesting an atypical adenoma.
  • Because of the suspicion that case #1 could be an atypical adenoma and case #2 a carcinoma further molecular studies were performed.
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Carcinoma / genetics. Carcinoma / pathology. Humans. Male. Middle Aged

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  • (PMID = 19092296.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK032333
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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4. Montenegro FL, Tavares MR, Durazzo MD, Cernea CR, Cordeiro AC, Ferraz AR: Clinical suspicion and parathyroid carcinoma management. Sao Paulo Med J; 2006 Jan 5;124(1):42-4
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  • One atypical adenoma was observed.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Hyperparathyroidism / surgery. Parathyroid Neoplasms / pathology

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  • (PMID = 16612462.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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5. Okamoto T, Iihara M, Obara T, Tsukada T: Parathyroid carcinoma: etiology, diagnosis, and treatment. World J Surg; 2009 Nov;33(11):2343-54
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  • The distinction between unequivocal and equivocal carcinoma (or atypical adenoma) was not always made for the study populations.
  • None of the patients with "atypical adenoma" developed recurrence, whereas 25% of those with "equivocal carcinoma" did.
  • [MeSH-minor] Adenoma. Humans. Mutation. Odds Ratio. Prognosis. Risk Factors. Sensitivity and Specificity. Survival Analysis

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  • (PMID = 19350316.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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6. Smolka W, Eggensperger N, Stauffer-Brauch EJ, von Bredow F, Lizuka T: Pleomorphic adenoma in an atypical location near the temporomandibular joint: a case report. Quintessence Int; 2007 May;38(5):417-21
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  • [Title] Pleomorphic adenoma in an atypical location near the temporomandibular joint: a case report.
  • In this report, a pleomorphic adenoma in an atypical location--the region of the temporomandibular joint (TMJ)--is presented.
  • This report shows that pleomorphic adenoma can be a possible diagnosis for lesions at the joint capsule.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Temporomandibular Joint / pathology. Temporomandibular Joint Disorders / pathology

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  • (PMID = 17568841.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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7. Di Carlo I, Pulvirenti E, Toro A, Priolo GD: Adenoma or atypical hepatic focal nodular hyperplasia: role of preoperative imaging and laparoscopic treatment. Surg Laparosc Endosc Percutan Tech; 2010 Jun;20(3):e105-9
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  • [Title] Adenoma or atypical hepatic focal nodular hyperplasia: role of preoperative imaging and laparoscopic treatment.
  • Differentiation of focal nodular hyperplasia (FNH) and other hypervascular liver lesions, such as hepatocellular adenoma (HCA), is important because of the drastically different therapeutic approach.
  • However, FNH can be well distinguished only if it shows a typical aspect; alternatively, in the case of atypical FNH, imaging findings are not specific enough to provide a secure diagnosis and histologic verification of the lesion is required.
  • The pathologic examination diagnosed an atypical FNH nodule.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Focal Nodular Hyperplasia / diagnosis. Laparoscopy. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery

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  • (PMID = 20551788.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Saeger W, Lüdecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S: Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol; 2007 Feb;156(2):203-16
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  • The adenomas (100%) were classified into densely granulated GH cell adenomas (9.2%), sparsely granulated GH cell adenomas (6.3%), sparsely granulated prolactin (PRL) cell adenomas (8.9%), densely granulated PRL cell adenomas (0.3%), mixed GH/PRL cell adenomas (5.2%), mammosomatotropic adenomas (1.1%), acidophilic stem cell adenomas (0.2%), densely granulated ACTH cell adenomas (7.2%), sparsely granulated ACTH cell adenomas (7.9%), Crooke cell adenomas (0.03%), TSH cell adenomas (1.5%), FSH/LH cell adenomas (24.8%), null cell adenomas (19.3%), null cell adenoma, oncocytic variant (5.8%), and plurihormonal adenomas (1.3%).
  • Following the WHO classification of 2004, the new entity 'atypical adenoma' was found in 12 cases in 2005.

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  • (PMID = 17287410.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 98
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9. Lautz TB, Finegold MJ, Chin AC, Superina RA: Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy. J Pediatr Surg; 2008 Apr;43(4):751-4
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  • [Title] Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy.
  • An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans.
  • [MeSH-major] Adenoma, Liver Cell / chemically induced. Anticonvulsants / adverse effects. Carbamazepine / analogs & derivatives. Liver Neoplasms / chemically induced

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  • (PMID = 18405728.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 33CM23913M / Carbamazepine; VZI5B1W380 / oxcarbazepine
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10. Bondarenko VO, Depiui TI, Magomedov RB, Shapiro NA: [The role of urgent intraoperative morphological investigation in differential diagnostics of pretumor lesions and tumors of the thyroid]. Vestn Khir Im I I Grek; 2010;169(2):42-7
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  • It was shown that the data of intraoperative cytological and histological diagnostics were comparable, the cytological diagnosis of atypical adenoma being an indication to urgent histological investigation.

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  • (PMID = 20552789.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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11. Guarnieri V, Scillitani A, Muscarella LA, Battista C, Bonfitto N, Bisceglia M, Minisola S, Mascia ML, D'Agruma L, Cole DE: Diagnosis of parathyroid tumors in familial isolated hyperparathyroidism with HRPT2 mutation: implications for cancer surveillance. J Clin Endocrinol Metab; 2006 Aug;91(8):2827-32
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  • PATIENTS, METHODS, AND RESULTS: In a 40-yr-old male previously treated for parathyroid atypical adenoma, we screened the 17 translated HRPT2 exons and their exon-intron boundaries and found a germline frameshift mutation in exon 7 (685delAGAG) predicting a premature stop codon at nucleotides 767-769.
  • Biochemical and ultrasonographic evaluation uncovered a 27-yr-old hypercalcemic carrier niece with an atypical parathyroid adenoma, and a 43-yr-old normocalcemic carrier sister was found by ultrasonography to have an extrathyroidal nodule, which proved to be parathyroid carcinoma.
  • The index case, 12 yr after surgery, was normocalcemic, but ultrasonography revealed an extrathyroidal nodule in the contralateral hemithyroid tissue that proved to be atypical adenoma.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / genetics. Adenoma / surgery. Adult. Aged. Calcium / blood. Chromatography, High Pressure Liquid. Female. Heterozygote. Humans. Male. Middle Aged. Pedigree. Polymerase Chain Reaction. Sensitivity and Specificity

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  • [CommentIn] J Clin Endocrinol Metab. 2006 Aug;91(8):2861-3 [16894022.001]
  • (PMID = 16720667.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins; SY7Q814VUP / Calcium
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12. Dinleyici EC, Dogruel N, Acikalin MF, Tokar B, Oztelcan B, Ilhan H: An additional child case of an aldosterone-producing adenoma with an atypical presentation of peripheral paralysis due to hypokalemia. J Endocrinol Invest; 2007 Nov;30(10):870-2
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  • [Title] An additional child case of an aldosterone-producing adenoma with an atypical presentation of peripheral paralysis due to hypokalemia.
  • Aldosterone-producing adenoma, which is characterized by hypertension, hypokalemia, and elevated aldosterone levels with suppressed plasma renin activity, is a rare condition during childhood and is also potentially curable.
  • To the best of our knowledge, nearly 25 cases of childhood aldosterone-secreting adenoma have been reported in the literature to date.
  • Here we describe a 13-yr-old girl with primary hyperaldosteronism secondary to aldosterone-secreting adenoma.
  • Laparoscopic adrenalectomy was performed and histopathological examinations showed benign adrenal adenoma.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Hyperaldosteronism / etiology. Hypokalemia / etiology. Paralysis / etiology

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  • (PMID = 18075291.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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13. Juhlin CC, Nilsson IL, Johansson K, Haglund F, Villablanca A, Höög A, Larsson C: Parafibromin and APC as screening markers for malignant potential in atypical parathyroid adenomas. Endocr Pathol; 2010 Sep;21(3):166-77

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  • [Title] Parafibromin and APC as screening markers for malignant potential in atypical parathyroid adenomas.
  • A dilemma arises when tumours present with atypical histopathological features but lack direct evidence of malignancy.
  • We report results from APC and parafibromin expression analyses by immunohistochemistry and Western blot in five cases of atypical adenoma, a single case of carcinoma and 54 adenomas without atypical features.
  • Complete loss of APC immunoreactivity and reduced expression of parafibromin was evident in two of the atypical adenomas and in the parathyroid carcinoma.
  • We conclude that loss of APC is a frequent molecular event in atypical adenomas and carcinomas, but not in adenomas.
  • Furthermore, the molecular resemblance of atypical adenomas with carcinoma concerning parafibromin and APC expression indicates that atypical adenomas should be subjects to watchful follow-up.
  • [MeSH-major] Adenoma / metabolism. Adenomatous Polyposis Coli Protein / biosynthesis. Biomarkers, Tumor / analysis. Parathyroid Neoplasms / metabolism. Tumor Suppressor Proteins / biosynthesis

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  • (PMID = 20473645.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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14. Schittenhelm J, Psaras T, Honegger J, Trautmann K, Meyermann R, Beschorner R: No evidence for WT1 involvement in a beta-catenin-independent activation of the Wnt signaling pathway in pituitary adenomas. Endocr Pathol; 2009;20(3):158-62
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  • We investigated WT1 expression in 90 paraffin-embedded pituitary adenomas, including eight atypical adenomas, and in 28 nontumorous pituitary glands by immunohistochemistry.
  • Only two GHomas (including one atypical adenoma) and one gonadotropin-producing adenoma expressed WT1 in the cytoplasm of single tumor cells without nuclear staining.
  • [MeSH-major] Adenoma / metabolism. Pituitary Neoplasms / metabolism. Signal Transduction / physiology. WT1 Proteins / biosynthesis. beta Catenin / metabolism

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  • (PMID = 19437143.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transcription Factor Pit-1; 0 / WT1 Proteins; 0 / beta Catenin
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15. Marucci G, Faustini-Fustini M, Righi A, Pasquini E, Frank G, Agati R, Foschini MP: Thyrotropin-secreting pituitary tumours: significance of "atypical adenomas" in a series of 10 patients and association with Hashimoto thyroiditis as a cause of delay in diagnosis. J Clin Pathol; 2009 May;62(5):455-9
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  • [Title] Thyrotropin-secreting pituitary tumours: significance of "atypical adenomas" in a series of 10 patients and association with Hashimoto thyroiditis as a cause of delay in diagnosis.
  • BACKGROUND: Thyrotropin-secreting adenomas (TSH-As) are rare and, according to the World Health Organization criteria (WHO 2004), a significant proportion of them present features of atypical adenomas at the time of diagnosis.
  • AIMS: To determine the frequency of "atypical adenomas" and the significance of this definition as regards follow-up.
  • Three cases met the criteria for classification as atypical.
  • In none of the cases, including the three "atypical adenomas", were clinical or radiological signs of recurrence observed.
  • CONCLUSIONS: The three cases with features of atypical adenoma did not recur or metastasise, suggesting that, at least in the present series, a strict relationship between the morphological criteria for diagnosing atypical adenomas and biological behaviour may be sometimes lacking.
  • [MeSH-major] Adenoma / diagnosis. Hashimoto Disease / complications. Pituitary Neoplasms / diagnosis. Thyrotropin / secretion

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  • (PMID = 19098060.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9002-71-5 / Thyrotropin
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16. Liu FH, Hsueh C, Chao TC, Lin JD: Neck nodule and thyroid cancer in young without radiation exposure history. Pediatr Surg Int; 2009 Sep;25(9):785-8
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  • RESULTS: Of the 234 cases, 187 (79.9%) were surgically confirmed to be benign lesions, including four cases that were diagnosed as atypical adenoma.
  • [MeSH-minor] Adenoma / pathology. Adolescent. Biopsy, Fine-Needle. Carcinoma / pathology. Child. Child, Preschool. Cysts / pathology. Female. Hemangioma, Capillary / pathology. Humans. Infant. Lymphoma / pathology. Male. Neck / ultrasonography. Neurofibroma / pathology. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Thyroiditis / pathology. Young Adult

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  • (PMID = 19629501.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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17. Ogawa Y, Watanabe M, Tominaga T: Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report. Endocr Pathol; 2010 Jun;21(2):130-4
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  • [Title] Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report.
  • Atypical adenoma has an aggressive biological character, invades the surrounding structures, and grows rapidly.
  • Null cell adenoma generally grows slowly, but hormone secretion is little understood.
  • Atypical null cell adenoma is rare, and hormone production is unknown.
  • Histological examination showed atypical null cell adenoma with significant nuclear atypism and extensive necrosis.
  • Atypical null cell adenoma has an aggressive biological character, and immediate adjuvant treatment is essential.
  • [MeSH-major] Adenoma / pathology. Pituitary Neoplasms / pathology. Somatostatin / biosynthesis

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  • [ErratumIn] Endocr Pathol. 2010 Dec;21(4):277
  • (PMID = 20174891.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
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18. Raica M, Cimpean AM, Ribatti D: Angiogenesis in pre-malignant conditions. Eur J Cancer; 2009 Jul;45(11):1924-34
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  • Additional evidences came from pre-malignant lesions of glandular epithelia, in which the angiogenic switch was demonstrated by the immunohistochemical expression of VEGF in gastric metaplasia and dysplasia, in atypical adenoma of the colon, atypical hyperplasia and carcinoma in situ of the breast and others.

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  • (PMID = 19406633.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A
  • [Number-of-references] 93
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19. Ogawa Y, Tominaga T: A case of atypical thyrotroph cell adenoma, which re-grew within 3 months after surgery and required multimodal treatment. J Neurooncol; 2008 Mar;87(1):91-5
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  • [Title] A case of atypical thyrotroph cell adenoma, which re-grew within 3 months after surgery and required multimodal treatment.
  • OBJECTIVE AND IMPORTANCE: Thyrotroph cell adenoma accounts for only 1% of all pituitary adenomas.
  • Atypical adenoma has an aggressive biological character, invades the surrounding structures, and grows rapidly.
  • Atypical thyrotroph cell adenoma is extremely rare.
  • Histological examination showed atypical thyrotroph cell adenoma.
  • CONCLUSION: Atypical thyrotroph cell adenoma has an aggressive biological character and grows rapidly.
  • [MeSH-major] Adenoma / therapy. Neoplasm Recurrence, Local / therapy. Pituitary Neoplasms / therapy. Thyrotrophs / pathology

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  • (PMID = 17987261.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; RWM8CCW8GP / Octreotide
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20. Fernandez-Ranvier GG, Khanafshar E, Tacha D, Wong M, Kebebew E, Duh QY, Clark OH: Defining a molecular phenotype for benign and malignant parathyroid tumors. Cancer; 2009 Jan 15;115(2):334-44
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  • BACKGROUND: It is frequently difficult to establish histologically whether a parathyroid tumor is a parathyroid carcinoma, parathyromatosis, or an atypical adenoma.
  • METHODS: Samples of parathyroid carcinoma, atypical adenoma, parathyromatosis, parathyroid adenoma, and hyperplasia were obtained for tissue microarray studies.
  • RESULTS: Complete loss of parafibromin expression was seen in 5 of 16 (31.3%) parathyroid carcinomas; all parathyromatosis, atypical adenomas, adenomas, and hyperplasia stained positive for parafibromin.
  • Loss of Rb expression was seen in 5 (33.3%) of 15 parathyroid carcinomas and 1 (7.1%) of 14 parathyroid hyperplasias; all parathyromatosis, atypical adenomas, and adenomas stained positive.
  • Galectin-3 stained strongly positive in 14 (93.3%) of 15 parathyroid carcinomas, and positive in 3 (18.7%) of 16 cases of parathyromatosis, 2 (100%) of 2 atypical adenomas, 1 (5.6%) of 18 adenomas, and 2 (14.3%) of 14 hyperplasias.
  • The Ki-67 proliferative index was high in 9 (60%) of 15 parathyroid carcinomas, 1 (6.7%) of 15 cases of parathyromatosis, 1 (5.6%) of 18 adenomas, and no atypical adenomas or hyperplasia.
  • [MeSH-minor] Adenoma / diagnosis. Carcinoma / diagnosis. Female. Galectin 3 / analysis. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Parathyroid Diseases / diagnosis. Phenotype. Tissue Array Analysis. Tumor Suppressor Proteins / analysis

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  • [Copyright] Copyright (c) 2009 American Cancer Society.
  • (PMID = 19107770.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDC73 protein, human; 0 / Galectin 3; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Proteins
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21. Ogawa Y, Ikeda H, Tominaga T: Clinicopathological study of prognostic factors in patients with pituitary adenomas and Ki-67 labeling index of more than 3%. J Endocrinol Invest; 2009 Jul;32(7):581-4
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  • BACKGROUND: Pituitary adenoma is generally indolent, but an aggressive subtype including atypical adenoma has uncertain prognosis, and an unclear relationship between prognosis and morphology.
  • SUBJECTS AND METHODS: Patients with surgically treated pituitary adenomas with Ki-67 labeling index of more than 3% were retrospectively identified as 13 males and 20 females aged from 15 to 73 yr (mean 47.2 yr) among 527 patients with pituitary adenoma treated at the Department of Neurosurgery, Tohoku University and Department of Neurosurgery, Kohnan Hospital between January 2001 and December 2007.
  • CONCLUSIONS: Gross total removal is the most important prognostic factor in patients with adenoma with Ki-67 labeling index of more than 3%.
  • In contrast, giant adenoma carries higher risk of recurrence and/or re-growth.

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  • (PMID = 19509474.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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22. Sahli R, Christ ER, Seiler R, Kappeler A, Vajtai I: Clinicopathologic correlations of silent corticotroph adenomas of the pituitary: report of four cases and literature review. Pathol Res Pract; 2006;202(6):457-64
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  • With MIB-1 labeling indices of 1-3%, none of the tumors qualified as atypical adenoma.
  • Subtle morphologic evidence of corticotroph suppression in residual pituitary adjacent to tumor lends further support to literature data indicating minimal or intermittent functional activity in this tumor type.
  • [MeSH-major] Adenoma / pathology. Adrenocorticotropic Hormone / metabolism. Pituitary Gland, Anterior / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 16497445.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
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23. Lin JD, Chao TC, Huang BY, Chen ST, Chang HY, Hsueh C: Thyroid cancer in the thyroid nodules evaluated by ultrasonography and fine-needle aspiration cytology. Thyroid; 2005 Jul;15(7):708-17
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  • Of patients undergoing surgical treatment, 2761 (76.1%) patients were diagnosed with benign nodules, 858 (23.6%) with malignant nodules, and 10 (0.3%) with atypical adenoma (7 follicular and 3 Hürthle cells).

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  • (PMID = 16053388.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Ulu EM, Uyuşur A, Ekici Y, Hunca C, Coşkun M: Multidetector CT findings of spontaneous rupture of hepatic adenoma in a patient with hepatic adenomatosis. Diagn Interv Radiol; 2009 Jun;15(2):135-8
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  • [Title] Multidetector CT findings of spontaneous rupture of hepatic adenoma in a patient with hepatic adenomatosis.
  • We report the case of a 32-year-old woman who presented with a large intraparenchymal and subcapsular hematoma in the liver, and an underlying large adenoma with atypical radiologic characteristics detected with multidetector CT imaging.
  • On follow-up CT examination, a large adenoma was clearly visualized at the site of the previous hematoma.
  • [MeSH-major] Adenoma / diagnosis. Hematoma / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 19517384.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Contrast Media
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25. Santagata S, Hornick JL, Ligon KL: Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG. Am J Surg Pathol; 2006 Dec;30(12):1613-8
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  • NANOG was not detected in tumor types frequently considered in the differential diagnosis of CNS germinoma: pineoblastoma, primitive neuroectodermal tumors, medulloblastoma, lymphoma, pituitary adenoma, atypical teratoid/rhabdoid tumor, Langerhans cell histiocytosis, and gliomas.

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  • (PMID = 17122519.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS047213
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / HMGB Proteins; 0 / Homeodomain Proteins; 0 / Isoenzymes; 0 / NANOG protein, human; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / Transcription Factors; 0 / germ-cell AP isoenzyme; EC 3.1.3.1 / Alkaline Phosphatase
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26. Salgado LR, Machado MC, Cukiert A, Liberman B, Kanamura CT, Alves VA: Cushing's disease arising from a clinically nonfunctioning pituitary adenoma. Endocr Pathol; 2006;17(2):191-9
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  • [Title] Cushing's disease arising from a clinically nonfunctioning pituitary adenoma.
  • A 49-yr-old woman with a large pituitary tumor leading to visual loss and galactorrhea- amenorrhea was submitted to transcranial pituitary surgery, when a clinically nonfunctioning pituitary adenoma was partially removed.
  • Histopathology and immunohistochemistry confirmed the diagnosis of "non-secreting atypical adenoma."
  • [MeSH-major] Adenoma / complications. Adenoma / pathology. Pituitary ACTH Hypersecretion / etiology. Pituitary Neoplasms / complications. Pituitary Neoplasms / pathology

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  • (PMID = 17159252.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Osawa N, Onoda N, Kawajiri H, Tezuka K, Takashima T, Ishikawa T, Miyauchi A, Hirokawa M, Wakasa K, Hirakawa K: Diagnosis of parathyroid carcinoma using immunohistochemical staining against hTERT. Int J Mol Med; 2009 Dec;24(6):733-41
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  • The differential diagnosis of parathyroid carcinoma from benign adenoma is often difficult when its typical clinicopathological features are absent, even with the aid of various molecular markers.
  • In contrast, one atypical adenoma stained positively and homogeneously, and the disease recurred three times clinically.

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  • (PMID = 19885612.001).
  • [ISSN] 1791-244X
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / nucleolin; EC 2.7.7.49 / Telomerase
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28. Orfanos NF, Mariolis-Sapsakos T, Orfanos FN, Goutas N, Vlachodimitropoulos D, Antoniou AG: Giant parathyroid adenoma with atypical ultrasonographic image. Clin Nucl Med; 2007 Mar;32(3):239-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant parathyroid adenoma with atypical ultrasonographic image.
  • [MeSH-major] Adenoma / radionuclide imaging. Adenoma / ultrasonography. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / ultrasonography

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  • (PMID = 17314610.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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