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1. Schittenhelm J, Psaras T, Meyermann R, Honegger J, Beschorner R: Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. Folia Neuropathol; 2010;48(2):75-80
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  • MATERIAL AND METHODS: We investigated CDX2 expression in 28 normal pituitary glands, 75 pituitary adenomas of varying hormonal activity (including 7 invasive adenomas and 7 atypical adenomas) and 23 craniopharyngiomas (17 adamantinous and 6 papillary) in tissue microarrays.

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  • (PMID = 20602288.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins
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2. Varoglu AO, Aksoy A, Varoglu E: Parathyroid adenoma presenting as tetraparesia. Neuro Endocrinol Lett; 2010;31(4):451-3
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  • [Title] Parathyroid adenoma presenting as tetraparesia.
  • CONCLUSION: We suggest that the physicians always keep in mind the primary hyperparathyroidism (HPT) and concomitant Vitamin D deficiency in the differential diagnosis of hypercalcemia when facing atypical neurological symptoms such as tetraparesia.
  • [MeSH-major] Adenoma / complications. Parathyroid Neoplasms / complications. Quadriplegia / etiology. Vitamin D Deficiency / complications

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  • (PMID = 20802446.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 1406-16-2 / Vitamin D
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3. Juhlin CC, Nilsson IL, Johansson K, Haglund F, Villablanca A, Höög A, Larsson C: Parafibromin and APC as screening markers for malignant potential in atypical parathyroid adenomas. Endocr Pathol; 2010 Sep;21(3):166-77
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  • [Title] Parafibromin and APC as screening markers for malignant potential in atypical parathyroid adenomas.
  • A dilemma arises when tumours present with atypical histopathological features but lack direct evidence of malignancy.
  • We report results from APC and parafibromin expression analyses by immunohistochemistry and Western blot in five cases of atypical adenoma, a single case of carcinoma and 54 adenomas without atypical features.
  • Complete loss of APC immunoreactivity and reduced expression of parafibromin was evident in two of the atypical adenomas and in the parathyroid carcinoma.
  • We conclude that loss of APC is a frequent molecular event in atypical adenomas and carcinomas, but not in adenomas.
  • Furthermore, the molecular resemblance of atypical adenomas with carcinoma concerning parafibromin and APC expression indicates that atypical adenomas should be subjects to watchful follow-up.
  • [MeSH-major] Adenoma / metabolism. Adenomatous Polyposis Coli Protein / biosynthesis. Biomarkers, Tumor / analysis. Parathyroid Neoplasms / metabolism. Tumor Suppressor Proteins / biosynthesis

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  • (PMID = 20473645.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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4. Freitas LL, Araújo VC, Martins MT, Chone C, Crespo A, Altemani A: Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. Int J Surg Pathol; 2005 Oct;13(4):337-42
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  • [Title] Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation.
  • Diagnostic criteria for intracapsular carcinoma ex pleomorphic adenoma (CXPA) are subjective and vary among authors.
  • Few benign myoepithelial cells were p53 positive. c-erbB-2 reactivity was strongly associated with atypical luminal cells.
  • In PA with atypical cells, evaluation of the expression of these 2 markers provides more objective criteria for the diagnosis of intracapsular CXPA.
  • [MeSH-major] Adenoma, Pleomorphic / chemistry. Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic. Parotid Neoplasms / chemistry. Submandibular Gland Neoplasms / chemistry

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  • (PMID = 16273189.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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5. Choi YJ, Yun JS, Kim DH: Clinical and ultrasound features of cytology diagnosed follicular neoplasm. Endocr J; 2009;56(3):383-9
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  • Benign included 78 FA, 8 atypical FA, and 3 Hurthle cell adenomas.
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adult. Aged. Female. Humans. Male. Middle Aged. Thyroid Gland / pathology. Thyroid Gland / ultrasonography. Ultrasonography, Doppler, Color

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  • (PMID = 19164864.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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6. Tátrai P, Somorácz A, Batmunkh E, Schirmacher P, Kiss A, Schaff Z, Nagy P, Kovalszky I: Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions. Am J Surg Pathol; 2009 Jun;33(6):874-85
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  • The majority of benign lesions were clearly agrin-negative, whereas the strength and extent of agrin IHC faithfully reflected dysplasia in "atypical" HCAs and in high-grade dysplastic nodules.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Agrin / biosynthesis. Antigens, CD34 / biosynthesis. Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 19194276.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Agrin; 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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7. Czarkowski M, Dabrowska J: [Transient hyponatremia the first symptome of multiple endocrine neoplasia type 1 (MEN 1)--case report]. Pol Arch Med Wewn; 2005 Aug;114(2):768-72
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  • Removal of pituitary adenoma was done.
  • Presented MEN 1 was atypical because: 1.


8. Katabi N, Gomez D, Klimstra DS, Carlson DL, Lee N, Ghossein R: Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases. Hum Pathol; 2010 Jul;41(7):927-34
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  • [Title] Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases.
  • Carcinoma ex pleomorphic adenoma is a rare salivary gland neoplasm, especially when the malignant component is only intracapsular/minimally invasive.
  • Moreover, only few studies have assessed the behavior of carcinoma ex pleomorphic adenoma according to the histologic subtype.
  • Forty-three cases of carcinoma ex pleomorphic adenoma were identified over a 27-year period and subjected to a detailed histopathologic analysis.
  • There was a trend toward a higher frequency of myoepithelial carcinomas in widely invasive tumors (13/30, 43%) than in intracapsular/minimally invasive (2/13, 15%) carcinoma ex pleomorphic adenoma (P = .095).
  • Vascular invasion and distant metastases correlated with decreased disease-free survival and disease-specific survival (P < .05), whereas the extent of invasion and the presence of a high mitotic rate or atypical mitoses correlated with decreased disease-free survival only (P < .05).
  • Within the intracapsular/minimally invasive carcinoma ex pleomorphic adenoma group, both myoepithelial carcinoma (2/2, 100%) had metastatic disease, whereas only 1 of 11 nonmyoepithelial carcinoma relapsed (P = .038).
  • Vascular invasion, high mitotic rate, and histologic subtype were found to correlate with recurrence in carcinoma ex pleomorphic adenoma.
  • Patients with intracapsular/minimally invasive tumor have a more favorable outcome than patients with widely invasive neoplasm, but intracapsular/minimally invasive carcinoma ex pleomorphic adenoma can recur and cause death.
  • The presence of myoepithelial carcinoma subtype increases the risk of recurrence in carcinoma ex pleomorphic adenoma, especially within the group of intracapsular/minimally invasive tumors.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Carcinoma / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20338616.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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9. Molinié V, Baumert H: [New markers in prostate biopsies]. Actas Urol Esp; 2007 Oct;31(9):1009-24
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  • This has been accompanied by a strong increase in the number of biopsies with ambiguous lesions, and an unequivocal diagnosis of malignancy is difficult to render, especially in the case of limited foci or in small atypical acinar lesions.
  • When assessing small foci of atypical glands upon needle biopsy, the pathologist searches for differences between the benign glands and atypical glands in terms of usual morphological features and in such cases, immunohistochemical stains for basal cell markers such as 34betaE12 antibody or antibodies directed against cytokeratin 5 and 6 and more recently p63 may be a useful adjuvant to identify basal cells which are typically present in benign glands but absent in prostatic carcinoma.
  • However several benign mimickers of prostate carcinoma, including atrophy, atypical adenomatous hyperplasia, nephrogenic adenoma can stain negatively with these antibodies and thus a negative basal cell marker immunostain alone does not exclude a diagnosis of benignancy.

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  • (PMID = 18257370.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
  • [Number-of-references] 53
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10. Zheng L, Wu PH, Shen JX, Mo YX, Xie CM, Ruan CM, Li L: [Typical and atypical features of focal nodular hyperplasia of the liver on helical CT images]. Ai Zheng; 2006 Jul;25(7):861-5
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  • [Title] [Typical and atypical features of focal nodular hyperplasia of the liver on helical CT images].
  • This study was to evaluate the typical and atypical features of FNH of the liver on helical computed tomography (CT) images to improve the diagnosis accuracy.
  • Atypical helical CT features of FNH include heterogeneous enhancement in hepatic arterial phase, absence of central scar, and presence of pseudocapsule.
  • [MeSH-minor] Adenoma / radiography. Adolescent. Adult. Aged. Carcinoma, Hepatocellular / radiography. Diagnosis, Differential. Female. Humans. Liver Neoplasms / radiography. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 16831278.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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11. Ide F, Kikuchi K, Kusama K, Kanazawa H: Sialadenoma papilliferum with potentially malignant features. J Clin Pathol; 2010 Apr;63(4):362-4
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  • Histological features were also atypical: surface verrucous hyperplasia and deeper florid cystic-duct adenoma.
  • [MeSH-major] Adenoma / diagnosis. Mandibular Neoplasms / diagnosis. Papilloma / diagnosis

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  • (PMID = 20354209.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Buecher B, Bezieau S, Dufilhol C, Cauchin E, Heymann MF, Mosnier JF: [Emerging concepts in colorectal serrated polyps]. Gastroenterol Clin Biol; 2007 Jan;31(1):39-54
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  • These atypical serrated polyps may occur either sporadically or in the context of colorectal polyposis.
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17273130.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 90
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13. Ranganathan S, Lynshue K, Hunt JL, Kane T, Jaffe R: Unusual adrenal cortical tumor of unknown biologic potential: a nodule in a nodule in a nodule. Pediatr Dev Pathol; 2005 Jul-Aug;8(4):483-8
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  • Recent molecular data suggest an adenoma-to-carcinoma progression sequence in adrenal cortical neoplasms.
  • The bulk of the tumor was a large, yellow mass with typical features of an adrenal cortical adenoma.
  • In the center was a well-circumscribed tan-brown nodule that was distinct from the adenoma and had oncocytic features.
  • A third minute focus (3.0 mm) was noted that was not circumscribed or encapsulated, but showed marked pleomorphism and abundant mitoses, including atypical forms and increased Ki67 compared with the outer 2 nodules.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology

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  • (PMID = 16010500.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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14. Ulu EM, Uyuşur A, Ekici Y, Hunca C, Coşkun M: Multidetector CT findings of spontaneous rupture of hepatic adenoma in a patient with hepatic adenomatosis. Diagn Interv Radiol; 2009 Jun;15(2):135-8
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  • [Title] Multidetector CT findings of spontaneous rupture of hepatic adenoma in a patient with hepatic adenomatosis.
  • We report the case of a 32-year-old woman who presented with a large intraparenchymal and subcapsular hematoma in the liver, and an underlying large adenoma with atypical radiologic characteristics detected with multidetector CT imaging.
  • On follow-up CT examination, a large adenoma was clearly visualized at the site of the previous hematoma.
  • [MeSH-major] Adenoma / diagnosis. Hematoma / diagnosis. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 19517384.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Contrast Media
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15. Lefèvre M, Couturier J, Sibony M, Bazille C, Boyer K, Callard P, Vieillefond A, Allory Y: Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases. Am J Surg Pathol; 2005 Dec;29(12):1576-81
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  • However, the cases were atypical for type 1 papillary carcinoma (due to oncocytic cells and absence of trisomy 17) and for type 2 (due to a good outcome).
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / pathology. Cytogenetics. Immunohistochemistry. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology

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  • (PMID = 16327429.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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16. Matsuno A: [Recent trends in the pathophysiology and treatment of pituitary adenomas]. Brain Nerve; 2009 Aug;61(8):957-62
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  • This finding indicates that the endogenous expression of hypothalamic hormones and their receptors in human pituitary adenoma cells has ample significance in the autocrine or paracrine regulation of pituitary hormone production and tumor extension induced by hypothalamic hormones produced by adenoma cells.
  • The frequently used dopamine agonist, cabergoline, is very effective for treating prolactin-producing adenoma.
  • Long-acting octreotide and pegvisomant are now available for the treatment of growth hormone producing adenoma.
  • Cabergoline is also used for growth hormone producing adenoma.
  • Temozolomide has recently been used for atypical adenomas or pituitary carcinomas.
  • [MeSH-major] Adenoma / etiology. Adenoma / therapy. Pituitary Neoplasms / etiology. Pituitary Neoplasms / therapy

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  • (PMID = 19697885.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ergolines; 0 / Hypothalamic Hormones; 0 / Receptors, Neuropeptide; 0 / Receptors, Pituitary Hormone-Regulating Hormone; 0 / pegvisomant; 0 / somatotropin releasing hormone receptor; 12629-01-5 / Human Growth Hormone; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; 9015-71-8 / Corticotropin-Releasing Hormone; 9034-39-3 / Growth Hormone-Releasing Hormone; LL60K9J05T / cabergoline; RWM8CCW8GP / Octreotide
  • [Number-of-references] 32
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17. Hameed O, Humphrey PA: Immunohistochemistry in diagnostic surgical pathology of the prostate. Semin Diagn Pathol; 2005 Feb;22(1):88-104
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  • However, several benign mimickers of PC, including atrophy, atypical adenomatous hyperplasia (AAH), nephrogenic adenoma, and mesonephric hyperplasia, can stain negatively with these markers, and thus, a negative basal cell marker immunostain alone does not exclude a diagnosis of benignancy.
  • Alpha-methylacyl-coenzyme-A racemase (AMACR) is a sensitive marker of PC (except for a few uncommon variants: atrophic, foamy gland, and pseudohyperplastic variants), and its detection by immunohistochemical staining in atypical prostatic lesions can be very useful in confirming an impression of adenocarcinoma.


18. Khadse P, Prabhash K, Pramesh CS, Chaturvedi P, Shet T: Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma. Diagn Cytopathol; 2009 Sep;37(9):680-5
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  • He had been operated 2 years before for a pleomorphic adenoma of the parotid and had a healthy scar at that site.
  • FNAC from the pleural lesions showed myxoid background substance with entrapped cuboidal epithelial cells with atypical nuclei, which were interpreted as mesothelial cells.
  • Both mesotheliomas and pleomorphic adenomas metastatic to the pleura are biphasic tumors, but in a patient with history of pleomorphic adenoma, the latter should be kept as a foremost possibility.

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19373913.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; Q20Q21Q62J / Cisplatin
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19. Mun M, Kohno T: Efficacy of thoracoscopic resection for multifocal bronchioloalveolar carcinoma showing pure ground-glass opacities of 20 mm or less in diameter. J Thorac Cardiovasc Surg; 2007 Oct;134(4):877-82
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  • Histologic diagnoses showed 62 bronchioloalveolar carcinoma type A lesions, 28 type B lesions, and 15 type C lesions according to Noguchi's classification, and atypical adenomatous hyperplasia in 43 lesions (13 patients).
  • Patients with new lesions had a higher incidence of bronchioloalveolar carcinoma lesions of 3 mm or less in diameter (P = .0254) and atypical adenomatous hyperplasia (P = .011).
  • [MeSH-minor] Adenoma / pathology. Adenoma / radiography. Adenoma / surgery. Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17903500.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Tronnier M, Vogelbruch M: Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31. J Cutan Pathol; 2007 Dec;34 Suppl 1:58-63
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  • [Title] Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31.
  • The occurrence of an atypical fibroxanthoma in association with a syringocystadenoma papilliferum is reported.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cystadenoma / pathology. Hamartoma / pathology. Sweat Gland Neoplasms / pathology. Xanthomatosis / pathology

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  • (PMID = 17997741.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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21. Cetani F, Pardi E, Ambrogini E, Banti C, Viacava P, Borsari S, Bilezikian JP, Pinchera A, Marcocci C: Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment. J Endocrinol Invest; 2008 Oct;31(10):900-4
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  • HRPT2 and parafibromin studies improved the diagnostic accuracy in two patients with primary hyperparathyroidism (PHPT) referred to us after surgery, in whom the clinical data were at variance with the pathological diagnosis of adenoma and carcinoma, respectively.
  • Patient #2, with severe PHPT, had had the removal of a 3.5-cm tumor described histologically as adenoma.
  • Re-review of the initial histology showed a trabecular pattern, fibrous bands, and atypical mitoses, suggesting an atypical adenoma.
  • Because of the suspicion that case #1 could be an atypical adenoma and case #2 a carcinoma further molecular studies were performed.
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Carcinoma / genetics. Carcinoma / pathology. Humans. Male. Middle Aged

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  • (PMID = 19092296.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK032333
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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22. Cetani F, Pardi E, Banti C, Collecchi P, Viacava P, Borsari S, Fanelli G, Naccarato AG, Saponaro F, Berti P, Miccoli P, Pinchera A, Marcocci C: Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas. Endocr Relat Cancer; 2010 Mar;17(1):1-6
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  • We studied 154 parathyroid tumors (18 carcinomas (13 with distant metastases), six atypical adenomas, and 130 adenomas).
  • Immunostaining of beta-catenin was performed in all carcinomas and in 66 adenomas (including three atypical).
  • [MeSH-major] Adenoma / physiopathology. Carcinoma / physiopathology. Neoplasm Proteins / physiology. Parathyroid Neoplasms / physiopathology. Signal Transduction / physiology. Wnt Proteins / physiology. beta Catenin / physiology

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  • (PMID = 19755524.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Wnt Proteins; 0 / beta Catenin
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23. Laumonier H, Frulio N, Laurent C, Balabaud C, Zucman-Rossi J, Bioulac-Sage P: Focal nodular hyperplasia with major sinusoidal dilatation: a misleading entity. BMJ Case Rep; 2010;2010
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  • Although the diagnosis of FNH and hepatocellular adenoma (HCA) has made great progress over the last few years using modern imaging techniques, there are still in daily practice some difficulties concerning some atypical nodules.
  • [MeSH-minor] Adenoma, Liver Cell / pathology. Biopsy, Needle. Diagnosis, Differential. Dilatation, Pathologic / pathology. Dilatation, Pathologic / surgery. Female. Humans. Image Enhancement. Liver Neoplasms / pathology. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 22798311.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029855
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24. Saeger W, Lüdecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S: Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol; 2007 Feb;156(2):203-16
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  • The adenomas (100%) were classified into densely granulated GH cell adenomas (9.2%), sparsely granulated GH cell adenomas (6.3%), sparsely granulated prolactin (PRL) cell adenomas (8.9%), densely granulated PRL cell adenomas (0.3%), mixed GH/PRL cell adenomas (5.2%), mammosomatotropic adenomas (1.1%), acidophilic stem cell adenomas (0.2%), densely granulated ACTH cell adenomas (7.2%), sparsely granulated ACTH cell adenomas (7.9%), Crooke cell adenomas (0.03%), TSH cell adenomas (1.5%), FSH/LH cell adenomas (24.8%), null cell adenomas (19.3%), null cell adenoma, oncocytic variant (5.8%), and plurihormonal adenomas (1.3%).
  • Following the WHO classification of 2004, the new entity 'atypical adenoma' was found in 12 cases in 2005.

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  • (PMID = 17287410.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 98
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25. Gupta R, Dinda AK, Singh MK, Misra MC: Macrocystic serous cystadenocarcinoma of the pancreas: the first report of a new pattern of pancreatic carcinoma. J Clin Pathol; 2008 Mar;61(3):396-8
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  • Cystic pancreatic neoplasms are rare and include mucinous and microcystic cystadenoma (carcinomas) and the recently described macrocystic adenoma.
  • Numerous microscopic sections revealed a serous neoplasm with atypical nuclear features and focal invasion of the cyst wall.

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  • (PMID = 18305183.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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26. Shields JA, Eagle RC Jr, Shields CL, Brown GC, Lally SE: Malignant transformation of congenital hypertrophy of the retinal pigment epithelium. Ophthalmology; 2009 Nov;116(11):2213-6
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  • It had features typical of CHRPE, but there was a small elevated nodule within the flat component, and the diagnosis was adenoma of the retinal pigment epithelium (RPE) arising from CHRPE.
  • RESULTS: Histopathologically, the mass was composed of a proliferation of atypical RPE cells with a marked infiltration of benign plasma cells.

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  • (PMID = 19744732.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Mattsson C, Young WF Jr: Primary aldosteronism: diagnostic and treatment strategies. Nat Clin Pract Nephrol; 2006 Apr;2(4):198-208; quiz, 1 p following 230
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  • Primary aldosteronism is caused by bilateral idiopathic hyperplasia in approximately two-thirds of cases and aldosterone-producing adenoma in one-third.
  • In the clinical setting of normokalemic hypertension, patients who have resistant hypertension and hypertensive patients with a family history atypical for polygenic hypertension should be tested for primary aldosteronism.
  • Optimal treatment for aldosterone-producing adenoma or unilateral hyperplasia is unilateral laparoscopic adrenalectomy.
  • [MeSH-minor] Adenoma / complications. Adrenal Gland Neoplasms / complications. Adrenal Glands / radiography. Adrenalectomy. Aldosterone / blood. Aldosterone / urine. Algorithms. Animals. Antihypertensive Agents / pharmacology. Captopril / pharmacology. Fludrocortisone / analogs & derivatives. Fludrocortisone / pharmacology. Humans. Hypokalemia / etiology. Mineralocorticoid Receptor Antagonists. Renin / blood. Tomography, X-Ray Computed

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  • (PMID = 16932426.001).
  • [ISSN] 1745-8323
  • [Journal-full-title] Nature clinical practice. Nephrology
  • [ISO-abbreviation] Nat Clin Pract Nephrol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Mineralocorticoid Receptor Antagonists; 4964P6T9RB / Aldosterone; 514-36-3 / fludrocortisone acetate; 9G64RSX1XD / Captopril; EC 3.4.23.15 / Renin; U0476M545B / Fludrocortisone
  • [Number-of-references] 91
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28. Terkivatan T, Hussain SM, De Man RA, Ijzermans JN: Diagnosis and treatment of benign focal liver lesions. Scand J Gastroenterol Suppl; 2006;(243):102-15
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  • RESULTS: Although atypical imaging features are the exception rather than the rule, it is sometimes difficult to differentiate between benign and malignant lesions, and knowledge of their imaging features is essential if unnecessary work-up is to be avoided.
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adenoma, Liver Cell / therapy. Angiomyolipoma / diagnosis. Angiomyolipoma / therapy. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / therapy. Echinococcosis, Hepatic / diagnosis. Echinococcosis, Hepatic / therapy. Embolization, Therapeutic. Hamartoma / diagnosis. Hamartoma / therapy. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / therapy. Hepatectomy. Humans

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  • (PMID = 16782629.001).
  • [ISSN] 0085-5928
  • [Journal-full-title] Scandinavian journal of gastroenterology. Supplement
  • [ISO-abbreviation] Scand. J. Gastroenterol. Suppl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 144
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29. Altemani A, Martins MT, Freitas L, Soares F, Araújo NS, Araújo VC: Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology; 2005 Jun;46(6):635-41
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  • [Title] Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression.
  • AIMS: To characterize the cellular component in pleomorphic adenoma (PA) that undergoes malignant transformation in carcinoma ex pleomorphic adenoma (CXPA).
  • CXPA with only epithelial differentiation showed two types of malignant areas in the part of the tumour that was confined by the PA capsule: (i) intraductal carcinoma areas characterized by ductal structures containing both benign myoepithelial cells positive for alpha-smooth muscle actin (alpha-SMA), vimentin and cytokeratin (CK)14 and proliferating atypical luminal cells reactive for CK7, CK8 and CK19, and (ii) carcinoma areas composed only of epithelial cells reactive for CK7, CK8 and CK19.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Biomarkers, Tumor / analysis

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  • (PMID = 15910594.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / KRT14 protein, human; 0 / KRT7 protein, human; 0 / Keratin-14; 0 / Keratin-7; 0 / Vimentin; 68238-35-7 / Keratins
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30. Hameed O, Humphrey PA: Pseudoneoplastic mimics of prostate and bladder carcinomas. Arch Pathol Lab Med; 2010 Mar;134(3):427-43
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  • CONCLUSIONS: Pseudoneoplastic lesions in the prostate include those of prostatic epithelial origin, the most common being atrophy, adenosis (atypical adenomatous hyperplasia), basal cell hyperplasia, and crowded benign glands, as well as those of nonprostatic origin, such as seminal vesicle epithelium.
  • Several lesions can mimic invasive urothelial carcinoma, including pseudocarcinomatous hyperplasia, von Brunn nests, and nephrogenic adenoma.

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  • (PMID = 20196670.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 83
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31. Losa M, Mazza E, Terreni MR, McCormack A, Gill AJ, Motta M, Cangi MG, Talarico A, Mortini P, Reni M: Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: experience in six cases. Eur J Endocrinol; 2010 Dec;163(6):843-51
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  • OBJECTIVE: The prognosis of either pituitary carcinoma or aggressive pituitary adenoma resistant to standard therapies is poor.
  • DESIGN: This was a 1-year prospective study of temozolomide therapy in six consecutive patients with pituitary carcinoma (one case) or atypical pituitary adenoma (five cases) resistant to standard therapies.
  • Temozolomide was given orally at a dose of 150-200 mg/m(2) per day for 5 days every 4 weeks for a maximum of 12 cycles.
  • CONCLUSIONS: Temozolomide treatment has a wide range of efficacy in patients with pituitary carcinoma or locally aggressive pituitary adenoma.

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  • (PMID = 20870708.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
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32. Choi JC, Baek YH, Jeong JS, Lee SW, Han SY, Cho JH: Discrete hypoechoic ring in hepatic cavernous hemangioma resembling a malignant tumor: correlation with histologic features. Gut Liver; 2009 Sep;3(3):226-30
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  • Differential diagnoses of hepatic nodules include hepatocellular carcinoma, focal nodular hyperplasia, hepatic adenoma, regenerative nodule, focal fatty changes, and hemangioma.
  • They also sometimes have atypical findings, for example an internal echogenicity including hypoechogenicity, heterogeneous echogenicity, hyperechoic rim, central hypoechogenicity due to various changes (e.g., internal hemorrhage, necrosis, thrombosis, myxomatous change, and fibrosis), and (rarely) calcification.
  • We report herein the case of an atypical hemangioma presenting with a hypoechoic peripheral ring, mimicking a hepatic malignancy.

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  • (PMID = 20431752.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852708
  • [Keywords] NOTNLM ; Hemangioma / Hepatic malignancy / Hypoechoic ring / Ultrasonography
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33. Wang LP, Yang GZ, Li L, Zhou ZY, Gao BL, Wang B, Han Y: [Clinicopathological and immunohistochemical features of colorectal sessile serrated adenoma]. Zhonghua Zhong Liu Za Zhi; 2009 Apr;31(4):269-73
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  • [Title] [Clinicopathological and immunohistochemical features of colorectal sessile serrated adenoma].
  • OBJECTIVE: To investigate the clinicopathological characteristics and expression status of Ki67, p53, CEA, CDX, CK7 in colorectal sessile serrated adenoma (SSA).
  • RESULTS: The major histological features in SSA were architectural abnormality in crypts, dilatation of serrated crypt bases like an inverted "T" or "L" shape adjacent to muscularis mucosa.
  • Atypical cells containing round to oval nuclei and nucleoli were also observed.
  • CONCLUSION: Morphological diagnosis of SSA was mainly based on crypt architectural and cellular abnormalities, and the crypt architectural abnormality may be more important than cellular features.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Ki-67 Antigen / metabolism. Rectal Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adenoma, Villous / metabolism. Adenoma, Villous / pathology. Adult. Aged. Carcinoembryonic Antigen / metabolism. Colonic Polyps / metabolism. Colonic Polyps / pathology. Diagnosis, Differential. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratin-7 / metabolism. Male. Middle Aged. Retrospective Studies. Trans-Activators / metabolism

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  • (PMID = 19615281.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Homeodomain Proteins; 0 / Keratin-7; 0 / Ki-67 Antigen; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 156560-97-3 / Cdx-2-3 protein
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34. Lim YJ, Lee SM, Shin JH, Koh HC, Lee YH: Virilizing adrenocortical oncocytoma in a child: a case report. J Korean Med Sci; 2010 Jul;25(7):1077-9
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  • The completely resected tumor composed predominantly of oncocytes without atypical mitosis and necrosis.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Adrenal Cortex Neoplasms / complications. Virilism / etiology

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  • (PMID = 20592902.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2890887
  • [Keywords] NOTNLM ; Adenoma, Oxyphilic / Adrenal Cortex Neoplasms / Child / Virilism
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35. Thomas AA, Rackley RR, Lee U, Goldman HB, Vasavada SP, Hansel DE: Urethral diverticula in 90 female patients: a study with emphasis on neoplastic alterations. J Urol; 2008 Dec;180(6):2463-7
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  • Superficial changes associated with invasive carcinoma included villous adenoma in 1 case, intestinal metaplasia in 2 and high grade dysplasia in 3.
  • Of the 90 patients the remaining 82 demonstrated benign findings, including nephrogenic adenoma in 10 (11%).
  • CONCLUSIONS: Although most cases of surgically resected diverticula demonstrate benign features, approximately 10% show atypical glandular findings, including invasive adenocarcinoma.

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  • (PMID = 18930487.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. Doraiswamy PM, Schott G, Star K, Edwards R, Mueller-Oerlinghausen B: Atypical antipsychotics and pituitary neoplasms in the WHO database. Psychopharmacol Bull; 2007;40(1):74-6
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  • [Title] Atypical antipsychotics and pituitary neoplasms in the WHO database.
  • Amisulpride and risperidone are potent dopamine D2 receptor blocking atypical antipsychotics that can cause hyperprolactinemia.
  • We conclude that there is a need for prospective studies to confirm causality and suggest that clinicians, until then, would consider a pituitary adenoma in patients experiencing severe hyperprolactinemia or associated symptoms when receiving potent D2 antagonists [corrected]
  • [MeSH-major] Adenoma / chemically induced. Antipsychotic Agents / adverse effects. Pituitary Neoplasms / chemically induced. Risperidone / adverse effects. Schizophrenia / drug therapy. Sulpiride / analogs & derivatives

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  • [ErratumIn] Psychopharmacol Bull. 2007;40(2):5
  • (PMID = 17285098.001).
  • [ISSN] 0048-5764
  • [Journal-full-title] Psychopharmacology bulletin
  • [ISO-abbreviation] Psychopharmacol Bull
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antipsychotic Agents; 7MNE9M8287 / Sulpiride; AA0G3TW31W / sultopride; L6UH7ZF8HC / Risperidone
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37. Zawiślak J, Polberg K, Remer M, Stepulak A: [The case of pleomorphic adenoma in inferior nasal concha]. Otolaryngol Pol; 2007;61(4):643-5
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  • [Title] [The case of pleomorphic adenoma in inferior nasal concha].
  • The tumor which turned out to be pleomorphic adenoma was detected accidentally at 28 years old patient with a nose injury.
  • This localisation of pleomorphic adenoma is extremely rare.
  • Reports of a literature of pleomorphic tumors located in atypical places were quoted.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Nose Neoplasms / diagnosis. Nose Neoplasms / surgery. Turbinates / surgery

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  • (PMID = 18260269.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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38. Wani S, Hao Z: Atypical cystic adenoma of the parathyroid gland: case report and review of literature. Endocr Pract; 2005 Nov-Dec;11(6):389-93
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  • [Title] Atypical cystic adenoma of the parathyroid gland: case report and review of literature.
  • OBJECTIVE: To describe the clinical course of a patient with atypical cystic parathyroid adenoma manifesting as hypercalcemic parathyroid crisis.
  • METHODS: We present a case report and review the relevant literature on parathyroid cysts and atypical cystic parathyroid adenomas.
  • The final pathologic diagnosis was an atypical cystic parathyroid adenoma.
  • Atypical cystic parathyroid adenomas are rare and have an unpredictable clinical course.

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  • (PMID = 16638726.001).
  • [ISSN] 1530-891X
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  • [Number-of-references] 21
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39. Pino Rivero V, Pantoja Hernández CG, González Palomino A, Trinidad Ruíz G, Marcos García M, Keituqwa Yáñez T, Pardo Romero G, Blasco Huelva A: [Usefulness of computed tomography and magnetic resonance in the preoperative diagnosis for hyperparathyroidism]. An Otorrinolaringol Ibero Am; 2005;32(5):491-8
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  • We think both complementary explorations must not be solicited by routine but they can represent a help in the cases in that sonnography and scintigraphy are not able to show the possible adenoma or hiperplasia, particularly in recurrent hyperparathyroidisms, reinterventions or suspect of parathyroid glands in an atypical location.

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  • (PMID = 16318093.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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40. Lafferty FW, Hamlin CR, Corrado KR, Arnold A, Shuck JM: Primary hyperparathyroidism with a low-normal, atypical serum parathyroid hormone as shown by discordant immunoassay curves. J Clin Endocrinol Metab; 2006 Oct;91(10):3826-9
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  • [Title] Primary hyperparathyroidism with a low-normal, atypical serum parathyroid hormone as shown by discordant immunoassay curves.
  • After localization of a parathyroid adenoma by [(18)F]fluorodesoxyglucose positron emission tomography scanning, a 120-mg parathyroid adenoma was removed with the achievement of normocalcemia for the subsequent 2 yr.
  • PTH gene sequence analysis was performed from DNA extracted both from the parathyroid adenoma and the patient's peripheral blood leukocytes.
  • No intragenic mutations in the pre-pro-PTH coding region were found in either the parathyroid adenoma or matched blood DNA samples.
  • CONCLUSIONS: The discordant preoperative immunoassay curves with dilution could not be explained by the adenoma producing a mutated PTH.
  • Furthermore, an autoantibody against the PTH produced by the adenoma is ruled out by the prompt loss of the dilution effect in the three PTH assays within 1 wk of the adenoma's excision.
  • A posttranslational effect on the PTH molecule within the adenoma remains a possible explanation for the discordant immunoassay curves.
  • Repeated PTH measurements after serum dilution in suspected cases of PHP with low-normal PTH levels may be a useful method for detecting atypical forms of PTH.

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  • (PMID = 16849415.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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41. Kazakov DV, Mikyskova I, Kutzner H, Simpson RH, Hes O, Mukensnabl P, Bouda J, Zamecnik M, Kinkor Z, Michal M: Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus. Am J Dermatopathol; 2005 Apr;27(2):102-10
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  • Other histopathological findings observed in this series, analogous to benign breast disease, included sclerosing adenosis-like changes, atypical apocrine adenosis-like changes, changes corresponding to usual ductal epithelial hyperplasia, epitheliomatosis with a streaming growth pattern, lamprocyte-like changes, clear cell change of the myoepithelium, foamy histiocyte reaction, and stromal fibrosis.
  • Oxyphilic metaplasia, areas with solid growth, and changes simulating atypical apocrine adenosis are rare and poorly recognized in hidradenoma papilliferum and may cause diagnostic difficulties; in our cases several submitting pathologists suspected malignancy.
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Adult. Aged. Animals. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Papillomaviridae. Papillomavirus Infections / complications. Papillomavirus Infections / pathology. Polymerase Chain Reaction

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  • (PMID = 15798433.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Hard GC, Seely JC: Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN). Toxicol Pathol; 2005;33(6):641-9
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  • Criteria were developed to distinguish these CPN-associated lesions from atypical tubule hyperplasia, a precursor of adenoma, both of which were also represented in this survey of advanced CPN.
  • [MeSH-major] Adenoma / diagnosis. Aging / pathology. Carcinogens / toxicity. Kidney Diseases / diagnosis. Kidney Neoplasms / diagnosis. Kidney Tubules / pathology. Precancerous Conditions / diagnosis

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  • (PMID = 16207638.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens
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43. Okubo C, Morishita Y, Minami Y, Ishiyama T, Kano J, Iijima T, Noguchi M: Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Mol Carcinog; 2005 Feb;42(2):121-6
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  • [Title] Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
  • The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH).
  • The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in the adenoma tissue than in normal lung.
  • Previous studies of human adenocarcinomas have shown that the two proteins are expressed reciprocally; SP-A and lysozyme are differential markers of atypical adenomatous hyperplasia (AAH) and non-goblet cell type adenocarcinoma, and of goblet cell type adenocarcinoma, respectively.
  • Thus, the present results indicate that the phenotype of NNK-induced A/J mouse adenoma differs from that of AAH, which is thought to be a preinvasive lesion of human adenocarcinoma.
  • [MeSH-major] Adenoma / chemically induced. Adenoma / pathology. Carcinogens. Nitrosamines

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  • [Copyright] Copyright 2004 Wiley-Liss, Inc.
  • (PMID = 15584020.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoproteins; 0 / Carcinogens; 0 / DNA, Complementary; 0 / Nitrosamines; 0 / Pulmonary Surfactant-Associated Protein A; 0 / RNA, Messenger; 0 / Surface-Active Agents; 0 / Viral Proteins; 63231-63-0 / RNA; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; EC 2.7.7.- / bacteriophage T7 RNA polymerase; EC 2.7.7.6 / DNA-Directed RNA Polymerases; EC 3.2.1.17 / Muramidase
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44. Marucci G, Faustini-Fustini M, Righi A, Pasquini E, Frank G, Agati R, Foschini MP: Thyrotropin-secreting pituitary tumours: significance of "atypical adenomas" in a series of 10 patients and association with Hashimoto thyroiditis as a cause of delay in diagnosis. J Clin Pathol; 2009 May;62(5):455-9
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  • [Title] Thyrotropin-secreting pituitary tumours: significance of "atypical adenomas" in a series of 10 patients and association with Hashimoto thyroiditis as a cause of delay in diagnosis.
  • BACKGROUND: Thyrotropin-secreting adenomas (TSH-As) are rare and, according to the World Health Organization criteria (WHO 2004), a significant proportion of them present features of atypical adenomas at the time of diagnosis.
  • AIMS: To determine the frequency of "atypical adenomas" and the significance of this definition as regards follow-up.
  • Three cases met the criteria for classification as atypical.
  • In none of the cases, including the three "atypical adenomas", were clinical or radiological signs of recurrence observed.
  • CONCLUSIONS: The three cases with features of atypical adenoma did not recur or metastasise, suggesting that, at least in the present series, a strict relationship between the morphological criteria for diagnosing atypical adenomas and biological behaviour may be sometimes lacking.
  • [MeSH-major] Adenoma / diagnosis. Hashimoto Disease / complications. Pituitary Neoplasms / diagnosis. Thyrotropin / secretion


45. Rushing EJ, Bouffard JP, McCall S, Olsen C, Mena H, Sandberg GD, Thompson LD: Primary extracranial meningiomas: an analysis of 146 cases. Head Neck Pathol; 2009 Jun;3(2):116-30
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  • Histologically, the majority of tumors were meningothelial (77.4%), followed by atypical (7.5%), psammomatous (4.1%) and anaplastic (2.7%).
  • The differential diagnosis included a number of mesenchymal and epithelial tumors (paraganglioma, schwannoma, carcinoma, melanoma, neuroendocrine adenoma of the middle ear), depending on the anatomic site of involvement.

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  • (PMID = 19644540.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Keywords] NOTNLM ; Extracranial / Immunohistochemistry / Meningioma / Prognosis / Radiation / WHO classification
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46. Iacobone M, Masi G, Barzon L, Porzionato A, Macchi V, Ciarleglio FA, Palù G, De Caro R, Viel G, Favia G: Hyperparathyroidism-jaw tumor syndrome: a report of three large kindred. Langenbecks Arch Surg; 2009 Sep;394(5):817-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • HPT was diagnosed in virtually all affected patients, at a median age of 36.3 years (range 11-71).
  • Parathyroid carcinoma, atypical parathyroid adenoma, and jaw tumor occurred in one case; uterine involvement in 61.5% of women; other associated neoplasms were thyroid carcinoma (two cases) and renal and colon carcinoma (one case).
  • [MeSH-minor] Adenoma / genetics. Adolescent. Adult. Aged. Child. Female. Germ-Line Mutation. Heterozygote. Humans. Immunohistochemistry. Male. Middle Aged. Pedigree. Tumor Suppressor Proteins / analysis. Tumor Suppressor Proteins / genetics. Young Adult

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  • (PMID = 19529956.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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47. Ogawa Y, Watanabe M, Tominaga T: Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report. Endocr Pathol; 2010 Jun;21(2):130-4
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  • [Title] Somatostatin-producing atypical null cell adenoma manifesting as severe hypopituitarism and rapid deterioration--case report.
  • Atypical adenoma has an aggressive biological character, invades the surrounding structures, and grows rapidly.
  • Null cell adenoma generally grows slowly, but hormone secretion is little understood.
  • Atypical null cell adenoma is rare, and hormone production is unknown.
  • Histological examination showed atypical null cell adenoma with significant nuclear atypism and extensive necrosis.
  • Atypical null cell adenoma has an aggressive biological character, and immediate adjuvant treatment is essential.
  • [MeSH-major] Adenoma / pathology. Pituitary Neoplasms / pathology. Somatostatin / biosynthesis

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  • [ErratumIn] Endocr Pathol. 2010 Dec;21(4):277
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  • (PMID = 20174891.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
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48. Guyader D, Latournerie M: [Incidental ultrasound finding of a 3 cm liver nodule in a 45-year-old woman taking hormonal substitution after hysterectomy performed for cervix carcinoma]. Gastroenterol Clin Biol; 2009 Oct;33(10-11 Suppl):F60-7
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  • If the non tumorous liver is normal, focal nodular hyperplasia and hepatocellular adenoma should be differentiated.
  • The distinction between these two tumors is important because only hepatic adenoma carries a significant risk of complications (bleeding or hepatocellular carcinoma) leading to surgical resection of lesions that do not regress after steroid withdrawal.
  • Contrast enhanced MRI and contrast ultrasound are most useful tools for the diagnosis of nodular regenerative hyperplasia but liver biopsy can be necessary in atypical forms.
  • In recent years, the understanding of molecular mechanisms associated with adenoma occurrence allowed for the proposal of a new classification already of practical interest in the management of patients.
  • [MeSH-major] Adenoma, Liver Cell / ultrasonography. Contrast Media. Liver Neoplasms / ultrasonography. Ultrasonography, Doppler, Color

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  • (PMID = 19766417.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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49. Kohno T, Kunitoh H, Suzuki K, Yamamoto S, Kuchiba A, Matsuno Y, Yanagitani N, Yokota J: Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias. Carcinogenesis; 2008 May;29(5):957-63
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  • [Title] Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias.
  • The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC).
  • All the ADC cases were subjected to lobectomy and subsequent pathological investigation of atypical adenomatous hyperplasia (AAH), a putative precursor for peripheral lung ADC, including bronchioloalveolar carcinoma, in the resected lobes.

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  • (PMID = 18299280.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Antigens, Nuclear; 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / PASD1 protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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50. Yener S, Saklamaz A, Demir T, Kebapcilar L, Bayraktar F, Canda S, Yesil S: Primary hyperparathyroidism due to atypical parathyroid adenoma presenting with peroneus brevis tendon rupture. J Endocrinol Invest; 2007 May;30(5):442-4
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  • [Title] Primary hyperparathyroidism due to atypical parathyroid adenoma presenting with peroneus brevis tendon rupture.
  • [MeSH-major] Adenoma / complications. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Tendon Injuries / etiology

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  • (PMID = 17598980.001).
  • [ISSN] 1720-8386
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51. Delbridge L: Solitary thyroid nodule: current management. ANZ J Surg; 2006 May;76(5):381-6
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  • An atypical fine needle biopsy mandates formal diagnostic excision.
  • Because it is not possible to distinguish a follicular carcinoma from a follicular adenoma on cytological grounds alone, this category must simply be interpreted as indicating a follicular tumour and up to 20% will be malignant.

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  • (PMID = 16768700.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 42
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52. Raica M, Cimpean AM, Ribatti D: Angiogenesis in pre-malignant conditions. Eur J Cancer; 2009 Jul;45(11):1924-34
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  • Additional evidences came from pre-malignant lesions of glandular epithelia, in which the angiogenic switch was demonstrated by the immunohistochemical expression of VEGF in gastric metaplasia and dysplasia, in atypical adenoma of the colon, atypical hyperplasia and carcinoma in situ of the breast and others.

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  • (PMID = 19406633.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers; 0 / Ki-67 Antigen; 0 / Vascular Endothelial Growth Factor A
  • [Number-of-references] 93
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53. Zhou JP, Yang ZL, Liu DC, Zhou JP: [Expression of galectin 3 and Sambucus nigra agglutinin and their clinicopathological significance in benign and malignant lesions of stomach]. Zhonghua Wei Chang Wai Ke Za Zhi; 2009 May;12(3):297-300
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  • The positive cases of gal-3 and/or SNA in peritumoral tissues and benign lesions showed mild- to severe-atypical hyperplasia of mucous epithelial cells.
  • [MeSH-minor] Adenoma / pathology. Adult. Aged. Female. Gastritis / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Polyps / pathology

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  • (PMID = 19434543.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Plant Lectins; 0 / Sambucus nigra lectins; EC 3.2.2.22 / Ribosome Inactivating Proteins
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54. Lautz TB, Finegold MJ, Chin AC, Superina RA: Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy. J Pediatr Surg; 2008 Apr;43(4):751-4
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  • [Title] Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy.
  • An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans.
  • [MeSH-major] Adenoma, Liver Cell / chemically induced. Anticonvulsants / adverse effects. Carbamazepine / analogs & derivatives. Liver Neoplasms / chemically induced

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  • (PMID = 18405728.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 33CM23913M / Carbamazepine; VZI5B1W380 / oxcarbazepine
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55. Somma J, Schlecht NF, Fink D, Khader SN, Smith RV, Cajigas A: Thyroid fine needle aspiration cytology: follicular lesions and the gray zone. Acta Cytol; 2010 Mar-Apr;54(2):123-31
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  • Based on our categorization scheme, which is directly comparable to the new system proposed by the National Cancer Institute (NCI), we quantitatively evaluated the cytomorphologic features of 99 "atypical" cases.
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Adult. Biopsy, Fine-Needle. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Multivariate Analysis

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  • (PMID = 20391966.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Cham E, Watkin W, Goldschmidt R, Liu L: Fine needle aspiration cytology of adrenocortical oncocytic neoplasm: a case report. Acta Cytol; 2010 Jul-Aug;54(4):627-34
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  • CONCLUSION: On FNA, cells from an AON can be hypercellular and cytologically atypical, which can be pitfalls for a malignant diagnosis.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Cortex Neoplasms / pathology

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  • (PMID = 20715669.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Zada G, Lin N, Laws ER Jr: Patterns of extrasellar extension in growth hormone-secreting and nonfunctional pituitary macroadenomas. Neurosurg Focus; 2010 Oct;29(4):E4
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  • Of the 13 GH-macroadenomas with isolated infrasellar extension, 5 (42%) met WHO criteria for atypical adenomas.
  • [MeSH-major] Adenoma / pathology. Growth Hormone-Secreting Pituitary Adenoma / pathology. Human Growth Hormone / secretion. Pituitary Neoplasms / pathology

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  • (PMID = 20887129.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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58. Gündüz K, Demirel S, Heper AO, Günalp I: A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature. Surv Ophthalmol; 2006 May-Jun;51(3):280-5
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  • [Title] A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature.
  • Histopathologic and immunohistochemical findings were consistent with atypical chondroid syringoma with eccrine differentiation.
  • The tumor can have benign, atypical, and malignant variants.
  • Our patient had the atypical variant, which is characterized by benign cytological features, as well as the presence of infiltrative margins and/or satellite nodules.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 16644368.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Reséndiz-Colosia JA, Alvarado-Cabrero I, Flores-Díaz R, Juan MH, Barroso-Bravo S, Gómez-Acosta F, Rodríguez-Cuevas SA: [Multiple maxillofacial brown tumors as primary hyperparathyroidism manifestation]. Gac Med Mex; 2008 Mar-Apr;144(2):155-60
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  • Using computed tomography, we noted a parathyroid tumor in an atypical location.
  • Surgical resection confirmed the presence of an adenoma.

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  • (PMID = 18590035.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 20
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60. Liu FH, Hsueh C, Chao TC, Lin JD: Neck nodule and thyroid cancer in young without radiation exposure history. Pediatr Surg Int; 2009 Sep;25(9):785-8
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  • RESULTS: Of the 234 cases, 187 (79.9%) were surgically confirmed to be benign lesions, including four cases that were diagnosed as atypical adenoma.
  • [MeSH-minor] Adenoma / pathology. Adolescent. Biopsy, Fine-Needle. Carcinoma / pathology. Child. Child, Preschool. Cysts / pathology. Female. Hemangioma, Capillary / pathology. Humans. Infant. Lymphoma / pathology. Male. Neck / diagnostic imaging. Neurofibroma / pathology. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity. Thyroiditis / pathology. Ultrasonography. Young Adult

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  • (PMID = 19629501.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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61. Simi M, Leardi S, Pietroletti R, Baschieri I, Catani M, Ronga G, Manili G, Capitano S: [Hyperthyroidism in the elderly]. Ann Ital Chir; 2005 Jan-Feb;76(1):19-22
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  • 26 presented a Multinodular Toxic Goiter (72.2%), whereas 9 patients complained of Plummer Adenoma (25%); only 1 patient showed Basedow disease (2.7%).
  • The remaining 9 patients (25%) were treated for the concomitance of atypical symptoms of hyperthyroidism.
  • We performed 15 total thyroidectomy, 7 "near totally", 8 sub-total, 6 hemithyroidectomy in case of Plummer adenoma.

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  • (PMID = 16035667.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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62. Yang GZ, Li J, Ding HY: [Nipple adenoma: report of 18 cases with review of literatures]. Zhonghua Bing Li Xue Za Zhi; 2009 Sep;38(9):614-6
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  • [Title] [Nipple adenoma: report of 18 cases with review of literatures].
  • OBJECTIVE: To investigate the clinicopathological and immunohistochemical features, diagnosis and differential diagnosis of nipple adenoma of the breast.
  • METHODS: Morphological observation and immunohistochemistry were applied to 18 cases of nipple adenoma with a review of the related literatures.
  • CONCLUSIONS: Nipple adenoma is an infrequent type of benign breast neoplasm, presenting as sclerosing papilloma, papillomatosis or florid sclerosing adenosis.
  • It is easily confused with atypical ductal hyperplasia/low grade ductal carcinoma in situ, invasive ductal carcinoma or low grade adenosquamous carcinoma.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Nipples / pathology

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  • (PMID = 20079190.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CK-34 beta E12; 0 / Keratin-5; 68238-35-7 / Keratins
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63. Aretz S, Uhlhaas S, Goergens H, Siberg K, Vogel M, Pagenstecher C, Mangold E, Caspari R, Propping P, Friedl W: MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype. Int J Cancer; 2006 Aug 15;119(4):807-14
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  • [Title] MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype.
  • Including 7 affected relatives, almost all MAP patients presented with either an attenuated (80%) or with an atypical phenotype (18%).
  • The phenotype of MAP is best characterised as attenuated or atypical, respectively.
  • [MeSH-minor] Adenoma / genetics. Adolescent. Adult. Aged. Child. Child, Preschool. Colorectal Neoplasms / genetics. Humans. Middle Aged. Phenotype

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16557584.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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64. Xie CM, Kubba H: Parotidectomy in children: indications and complications. J Laryngol Otol; 2010 Dec;124(12):1289-93
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  • The following pathology was encountered: atypical mycobacterial infection (8.38 per cent), pleomorphic adenoma (4.19 per cent), lymphatic malformation (2.10 per cent), haemangioma (2 per cent), first branchial cleft anomaly (2 per cent), follicular non-Hodgkin's lymphoma (2 per cent) and lipoblastoma (1.5 per cent).
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Mycobacterium Infections, Nontuberculous / surgery. Neoplasm Recurrence, Local / surgery. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 20519039.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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65. Papotti M, Volante M, Duregon E, Delsedime L, Terzolo M, Berruti A, Rosai J: Adrenocortical tumors with myxoid features: a distinct morphologic and phenotypical variant exhibiting malignant behavior. Am J Surg Pathol; 2010 Jul;34(7):973-83
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  • [Title] Adrenocortical tumors with myxoid features: a distinct morphologic and phenotypical variant exhibiting malignant behavior.
  • The recent observation by our group of an adrenal myxoid tumor with morphologically borderline features, but aggressive clinical behavior prompted us to review a series of 196 adrenocortical lesions, comprising 122 carcinomas and 74 adenomas, to define the morphologic, phenotypical and clinical characteristics of adrenocortical tumors with myxoid features.
  • Fourteen cases, including 12 carcinomas and 2 borderline tumors, formed the basis of this report, and were characterized by a variably abundant myxoid component (from 5% to 90% of tumor) and 2 distinct cellular growth patterns: the first (10 cases), mostly associated with a predominant myxoid stromal component, was made of small cells with mild atypia arranged in cords and microcysts; the second (4 cases) was characterized by focal myxoid changes in tumors otherwise similar to conventional adrenocortical carcinoma, with large atypical cells having an eosinophilic cytoplasm and a diffuse or nodular architecture.
  • Myxoid adrenocortical tumors probably represent a rare but histologically and phenotipically distinct entity and, although rare cases of benign lesions are on record, they seem to be generally associated to morphologic and clinical features of malignancy.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Adrenocortical Carcinoma / secondary. Mucins / metabolism

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  • (PMID = 20534995.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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66. Lin JD, Chao TC, Huang BY, Chen ST, Chang HY, Hsueh C: Thyroid cancer in the thyroid nodules evaluated by ultrasonography and fine-needle aspiration cytology. Thyroid; 2005 Jul;15(7):708-17
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  • Of patients undergoing surgical treatment, 2761 (76.1%) patients were diagnosed with benign nodules, 858 (23.6%) with malignant nodules, and 10 (0.3%) with atypical adenoma (7 follicular and 3 Hürthle cells).

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  • (PMID = 16053388.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, Price RE, Hittelman WN, Wistuba II, Kurie JM: Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res; 2005 Apr 15;65(8):3226-35
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  • Here, we report that mTOR inhibition blocked malignant progression in K-ras(LA1) mice, which undergo somatic activation of the K-ras oncogene and display morphologic changes in alveolar epithelial cells that recapitulate those of precursors of human lung adenocarcinoma.
  • Atypical alveolar hyperplasia, an early neoplastic change, was prominently associated with macrophages and expressed high levels of phospho-S6(Ser236/235).
  • mTOR inhibition in K-ras(LA1) mice by treatment with the rapamycin analogue CCI-779 reduced the size and number of early epithelial neoplastic lesions (atypical alveolar hyperplasia and adenomas) and induced apoptosis of intraepithelial macrophages.
  • [MeSH-minor] Adenoma / drug therapy. Adenoma / enzymology. Adenoma / genetics. Adenoma / pathology. Animals. Cell Line, Tumor. Cell Transformation, Neoplastic / drug effects. Cell Transformation, Neoplastic / metabolism. Disease Progression. Enzyme Activation. Hyperplasia. Macrophages, Alveolar / drug effects. Macrophages, Alveolar / enzymology. Macrophages, Alveolar / pathology. Mice. Mutation. Protein-Serine-Threonine Kinases / metabolism. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-akt. Ribosomal Protein S6 Kinases / biosynthesis. TOR Serine-Threonine Kinases

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  • (PMID = 15833854.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / P50 CA070907; United States / NCI NIH HHS / CA / R01 CA105155
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Proto-Oncogene Proteins; 624KN6GM2T / temsirolimus; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases; W36ZG6FT64 / Sirolimus
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68. Cabral ES, Auerbach A, Killian JK, Barrett TL, Cassarino DS: Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry. Am J Dermatopathol; 2006 Dec;28(6):465-71
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  • The histologic distinction between sebaceous adenomas and carcinomas may be challenging, especially in cases showing atypical features and in small or partial biopsies.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / chemistry. Adenoma / chemistry. Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p21 / analysis. Female. Humans. Hyperplasia. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptor, ErbB-2 / analysis. Tumor Suppressor Protein p53 / analysis


69. Logasundaram R, Amarawickrama H, Premachandra D, Hellquist H: Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1563-6
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  • [Title] Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features.
  • Carcinoma ex pleomorphic adenoma poses a challenge to diagnosis and treatment.
  • Herein we describe an extremely unusual case, which presented initially as an intracapsular carcinoma ex pleomorphic adenoma in the right parotid gland.
  • No ductal carcinoma as seen in the initial intracapsular carcinoma ex pleomorphic adenoma was identified.
  • This case report elucidates the atypical clinical behaviour and interesting histological features encountered within this group of salivary neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Myoepithelioma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18288478.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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70. Kelly TG, Shattuck TM, Reyes-Mugica M, Stewart AF, Simonds WF, Udelsman R, Arnold A, Carpenter TO: Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. J Bone Miner Res; 2006 Oct;21(10):1666-71
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  • [Title] Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation.
  • Histologic features typical of a benign adenoma were evident after surgical extirpation of the gland.
  • He was found to have a PT adenoma with aggressive features.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma / diagnosis. Germ-Line Mutation. Hyperparathyroidism, Primary / genetics. Parathyroid Neoplasms / diagnosis. Tumor Suppressor Proteins / genetics

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  • (PMID = 16995822.001).
  • [ISSN] 0884-0431
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K24-HD01288; United States / NCRR NIH HHS / RR / M01-RR000125
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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71. Nirenberg MS, Carroll MC: Atypical gout in the foot and ankle secondary to primary hyperparathyroidism. J Am Podiatr Med Assoc; 2007 May-Jun;97(3):245-7
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  • [Title] Atypical gout in the foot and ankle secondary to primary hyperparathyroidism.
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adenoma / surgery. Adult. Humans. Male. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17507538.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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72. Di Carlo I, Pulvirenti E, Toro A, Priolo GD: Adenoma or atypical hepatic focal nodular hyperplasia: role of preoperative imaging and laparoscopic treatment. Surg Laparosc Endosc Percutan Tech; 2010 Jun;20(3):e105-9
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  • [Title] Adenoma or atypical hepatic focal nodular hyperplasia: role of preoperative imaging and laparoscopic treatment.
  • Differentiation of focal nodular hyperplasia (FNH) and other hypervascular liver lesions, such as hepatocellular adenoma (HCA), is important because of the drastically different therapeutic approach.
  • However, FNH can be well distinguished only if it shows a typical aspect; alternatively, in the case of atypical FNH, imaging findings are not specific enough to provide a secure diagnosis and histologic verification of the lesion is required.
  • The pathologic examination diagnosed an atypical FNH nodule.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Focal Nodular Hyperplasia / diagnosis. Laparoscopy. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery

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  • (PMID = 20551788.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Kawashima ST, Usui T, Sano T, Iogawa H, Hagiwara H, Tamanaha T, Tagami T, Naruse M, Hojo M, Takahashi JA, Shimatsu A: P53 gene mutation in an atypical corticotroph adenoma with Cushing's disease. Clin Endocrinol (Oxf); 2009 Apr;70(4):656-7
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  • [Title] P53 gene mutation in an atypical corticotroph adenoma with Cushing's disease.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / complications. ACTH-Secreting Pituitary Adenoma / genetics. Adenoma / genetics. Mutation / genetics. Pituitary ACTH Hypersecretion / etiology. Pituitary Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 18771563.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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74. Guarnieri V, Scillitani A, Muscarella LA, Battista C, Bonfitto N, Bisceglia M, Minisola S, Mascia ML, D'Agruma L, Cole DE: Diagnosis of parathyroid tumors in familial isolated hyperparathyroidism with HRPT2 mutation: implications for cancer surveillance. J Clin Endocrinol Metab; 2006 Aug;91(8):2827-32
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  • PATIENTS, METHODS, AND RESULTS: In a 40-yr-old male previously treated for parathyroid atypical adenoma, we screened the 17 translated HRPT2 exons and their exon-intron boundaries and found a germline frameshift mutation in exon 7 (685delAGAG) predicting a premature stop codon at nucleotides 767-769.
  • Biochemical and ultrasonographic evaluation uncovered a 27-yr-old hypercalcemic carrier niece with an atypical parathyroid adenoma, and a 43-yr-old normocalcemic carrier sister was found by ultrasonography to have an extrathyroidal nodule, which proved to be parathyroid carcinoma.
  • The index case, 12 yr after surgery, was normocalcemic, but ultrasonography revealed an extrathyroidal nodule in the contralateral hemithyroid tissue that proved to be atypical adenoma.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / genetics. Adenoma / surgery. Adult. Aged. Calcium / blood. Chromatography, High Pressure Liquid. Female. Heterozygote. Humans. Male. Middle Aged. Pedigree. Polymerase Chain Reaction. Sensitivity and Specificity

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  • [CommentIn] J Clin Endocrinol Metab. 2006 Aug;91(8):2861-3 [16894022.001]
  • (PMID = 16720667.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins; SY7Q814VUP / Calcium
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75. Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC Jr, Hoang MP: Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol; 2009 Apr;22(4):600-10
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  • [Title] Atypical and malignant hidradenomas: a histological and immunohistochemical study.
  • The histological features of atypical hidradenoma are worrisome for increased risk of recurrence and possible malignant potential; however, earlier studies with immunohistochemistry or patient follow-up have not been reported.
  • We compare the histological features and Ki-67, phosphorylated histone H3, epidermal growth factor receptor, and Her2/neu expression profiles of 15 atypical and 15 malignant hidradenomas with those of benign hidradenoma and metastasizing adnexal carcinomas.
  • Significant difference in mean Ki-67% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.002), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (0.002).
  • Significant difference in mean phosphorylated histone H3% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.003), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (P<0.001).
  • Mean epidermal growth factor receptor total score was significantly different in benign and atypical hidradenoma when compared with that in metastasizing adnexal carcinoma (P=0.014 and 0.019, respectively).
  • Receiver operating characteristic curve analysis for Ki-67 and phosphorylated histone H3% positivity reveals statistically significant criterion values of >11.425 and >0.7, respectively, for distinguishing malignant hidradenomas from atypical hidradenomas.
  • Despite the presence of some worrisome histological features, the significantly different immunoprofile from the malignant counterpart suggests that atypical hidradenomas are likely to recur but are unlikely to metastasize.
  • A tumor with Ki-67>11% and/or phosphorylated histone H3>0.7% would likely be a malignant rather than an atypical hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Biomarkers, Tumor / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 19252473.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Histones; 0 / Ki-67 Antigen; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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76. Hari Kumar K, Jha S, Jha R, Modi KD: Conns' syndrome - atypical presentations. Saudi J Kidney Dis Transpl; 2009 Mar;20(2):278-81
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  • [Title] Conns' syndrome - atypical presentations.
  • Atypical presentations like normo-tension, normokalemia and neurological ailments are described in few cases.
  • Both the patients had a characteristic biochemical and imaging profile consistent with primary hyperaldosteronism and responded to surgical resection of adrenal adenoma.

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  • (PMID = 19237819.001).
  • [ISSN] 1319-2442
  • [Journal-full-title] Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • [ISO-abbreviation] Saudi J Kidney Dis Transpl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Mineralocorticoid Receptor Antagonists; 0 / Potassium Compounds; 27O7W4T232 / Spironolactone; RWP5GA015D / Potassium
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77. Demasi AP, Furuse C, Altemani A, Junqueira JL, Oliveira PR, Araújo VC: Peroxiredoxin I is overexpressed in oncocytic lesions of salivary glands. J Oral Pathol Med; 2009 Jul;38(6):514-7
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  • BACKGROUND: Oncocytic lesions, particularly frequent in the salivary glands, are characterized by cells with an atypical accumulation of mitochondria.
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Adenolymphoma / enzymology. Adenolymphoma / pathology. Adenoma, Oxyphilic / enzymology. Adenoma, Oxyphilic / pathology. Antioxidants / analysis. Biomarkers / analysis. Carcinoma, Mucoepidermoid / enzymology. Carcinoma, Mucoepidermoid / pathology. Free Radical Scavengers / analysis. Gene Expression Regulation, Enzymologic. Granular Cell Tumor / enzymology. Granular Cell Tumor / pathology. Humans. Hydrogen Peroxide / analysis. Hyperplasia. Lysosomes / pathology. Metaplasia. Mitochondria / pathology. Reactive Oxygen Species / analysis. Salivary Gland Neoplasms / enzymology. Salivary Gland Neoplasms / pathology. Thyroid Gland / pathology

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  • (PMID = 19298244.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Biomarkers; 0 / Free Radical Scavengers; 0 / Reactive Oxygen Species; BBX060AN9V / Hydrogen Peroxide; EC 1.11.1.15 / Peroxiredoxins
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78. Behzatoglu K, Bahadir B, Huq GE, Kaplan HH: Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review. Diagn Cytopathol; 2005 Jun;32(6):367-9
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  • [Title] Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review.
  • Although infarction of parotid gland pleomorphic adenoma (PA) following fine-needle aspiration (FNA) has been well-documented, spontaneous infarction of PA has remained as an uncommon entity in the literature.
  • Smears revealed abundant necrotic debris, atypical squamous cells, and small cells with dark nuclei suggestive of a carcinoma.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Adenoma, Pleomorphic / pathology. Infarction / pathology. Parotid Neoplasms / blood supply. Parotid Neoplasms / pathology

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  • (PMID = 15880698.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Ohtake H, Kawamura H, Matsuzaki M, Yokoyama E, Kitajima M, Onizuka S, Yamakawa M: Oncocytic adrenocortical carcinoma. Ann Diagn Pathol; 2010 Jun;14(3):204-8
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  • Nuclear atypia with atypical mitotic figures and capsular and sinusoidal invasions were observed.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adrenal Cortex Neoplasms / pathology. Adrenocortical Carcinoma / pathology

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  • (PMID = 20471567.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Biomarkers, Tumor
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80. Strehl MA, Scheich M, Ott I, Müller-Hermelink HK, Hagen R, Völker HU: [Middle ear adenoma/middle ear carcinoid--an unproblematic tumor?]. Laryngorhinootologie; 2009 Mar;88(3):186-90
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  • [Title] [Middle ear adenoma/middle ear carcinoid--an unproblematic tumor?].
  • The terms adenoma and carcinoid tumor of the middle ear can be used as synonyms, with the WHO favouring the term middle ear adenoma (MEA).
  • The histological differential diagnosis can also be problematic; in one case with a highly atypical morphology it was impossible to arrive at a definite diagnosis during the analysis of a frozen section.
  • [MeSH-major] Adenoma / diagnosis. Carcinoid Tumor / diagnosis. Ear Neoplasms / diagnosis. Ear, Middle

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  • (PMID = 19065497.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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81. Agha A, Carpenter R, Bhattacharya S, Edmonson SJ, Carlsen E, Monson JP: Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: two case reports of an unrecognised entity. J Endocrinol Invest; 2007 Feb;30(2):145-9
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  • Remarkably, she also reported primary amenorrhea and was found to have an invasive pituitary lactotroph adenoma, which was treated with cabergoline and external beam radiotherapy.
  • One of the parathyroid glands contained a tumor with fibrous banding, atypical mitoses, extra-capsular extension and moderate Ki 67 staining; features which are highly suggestive of carcinoma.


82. Salgado LR, Machado MC, Cukiert A, Liberman B, Kanamura CT, Alves VA: Cushing's disease arising from a clinically nonfunctioning pituitary adenoma. Endocr Pathol; 2006;17(2):191-9
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  • [Title] Cushing's disease arising from a clinically nonfunctioning pituitary adenoma.
  • A 49-yr-old woman with a large pituitary tumor leading to visual loss and galactorrhea- amenorrhea was submitted to transcranial pituitary surgery, when a clinically nonfunctioning pituitary adenoma was partially removed.
  • Histopathology and immunohistochemistry confirmed the diagnosis of "non-secreting atypical adenoma."
  • [MeSH-major] Adenoma / complications. Adenoma / pathology. Pituitary ACTH Hypersecretion / etiology. Pituitary Neoplasms / complications. Pituitary Neoplasms / pathology

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  • (PMID = 17159252.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Buła G, Waler J, Niemiec A, Koziołek H, Bichalski W, Gawrychowski J: Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy. Endokrynol Pol; 2010 Sep-Oct;61(5):427-9
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  • RESULTS: Among 7 patients with thyroid metastases from renal clear cell carcinoma, as diagnosed postoperatively, cytology of the thyroid material obtained through FNA revealed follicular tumour in 3 (43%) patients, tumour cells in 2 (28.5%) and atypical cells in the other 2 (28.5%).
  • Intraoperative histopathology confirmed the presence of metastasis from renal clear cell carcinoma (1) and indicated thyroid medullary cancer (1), follicular tumour (4), or trabecular adenoma with necrosis (1).
  • [MeSH-minor] Adenoma / pathology. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Neuroendocrine. Female. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Middle Aged. Monitoring, Intraoperative / methods

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  • (PMID = 21049452.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Thyroid cancer, medullary
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84. Shah SS, Chandan VS, Wilbur DC, Khurana KK: Glial fibrillary acidic protein and CD57 immunolocalization in cell block preparations is a useful adjunct in the diagnosis of pleomorphic adenoma. Arch Pathol Lab Med; 2007 Sep;131(9):1373-7
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  • [Title] Glial fibrillary acidic protein and CD57 immunolocalization in cell block preparations is a useful adjunct in the diagnosis of pleomorphic adenoma.
  • CONTEXT: The cytologic distinction between pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) can be diagnostically challenging in aspirate smears.
  • Hence a cytologic diagnosis of "atypical cytology" with a differential diagnosis including PA and ACC is occasionally rendered in a subset of salivary gland fine-needle aspirations.
  • (2) atypical cytology, cannot exclude ACC (8 cases); and (3) ACC (8 cases).
  • Of the 8 cases with diagnoses of atypical cytology, 4 (50%) were negative and 4 (50%) were positive for both GFAP and CD57.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Antigens, CD57 / metabolism. Glial Fibrillary Acidic Protein / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17824792.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Glial Fibrillary Acidic Protein
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85. Ippolito G, Palazzo FF, Sebag F, De Micco C, Henry JF: Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma. Br J Surg; 2007 May;94(5):566-70
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  • [Title] Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma.
  • BACKGROUND: Distinction of parathyroid cancer from atypical parathyroid adenoma (APA) at operation is difficult.
  • No recurrences were observed in the other seven patients in group 1 at a median follow-up of 65 months.
  • In group 2, eight patients had en bloc resection and eight had parathyroidectomy; no patient had recurrence at a median follow-up of 91 months.
  • [MeSH-major] Adenoma / diagnosis. Parathyroid Neoplasms / diagnosis. Parathyroidectomy / methods

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  • [CommentIn] Br J Surg. 2007 Aug;94(8):1043; author reply 1043-4 [17636522.001]
  • [CommentIn] Br J Surg. 2007 Aug;94(8):1042-3; author reply 1043-4 [17636521.001]
  • (PMID = 17380564.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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86. Arias D, Castellano VM, Córdoba S, Miñano R, Martínez D, Borbujo JM: [Atypical presentation of syringocystoadenoma papilliferum]. Actas Dermosifiliogr; 2006 Dec;97(10):647-9
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  • [Title] [Atypical presentation of syringocystoadenoma papilliferum].
  • We report a case of syringocystoadenoma papilliferum with an atypical presentation given its location in the thigh and the peculiar histologic features, unrepresentative of this entity.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Neoplasms, Second Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17173827.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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87. Heikkilä A, Siironen P, Hagström J, Heiskanen I, Sankila R, Louhimo J, Haglund C, Arola J: Follicular thyroid neoplasm: clinicopathologic features suggesting malignancy. APMIS; 2010 Nov;118(11):846-54
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  • All follicular carcinomas (n=39), atypical adenomas (n=6), and oxyphilic adenomas (n=15) were included in the study, as well as 30 consecutive conventional follicular adenomas.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma, Oxyphilic / pathology. Thyroid Neoplasms / pathology

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  • [Copyright] © 2010 The Authors. Journal Compilation © 2010 APMIS.
  • (PMID = 20955457.001).
  • [ISSN] 1600-0463
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CCND1 protein, human; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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88. Alba García JR, Armengot Carceller M, Zapater Latorre E, Pérez Valles A, Basterra Alegría A: Malignant fibrohistiocytoma of the parotid region. Report of a case. Med Oral Patol Oral Cir Bucal; 2008 Feb;13(2):E148-50
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  • We present a case of malignant fibrohistiocytoma with atypical features due to its location (in the parotid region), size and rapid growth.
  • Due to the low frequency of such lesions and their clinical behavior, the imaging study and fine-needle aspiration biopsy findings tend to diagnose them as pleomorphic adenoma.

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  • (PMID = 18223534.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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89. Inoue K, Yoshida M, Takahashi M, Shibutani M, Takagi H, Hirose M, Nishikawa A: Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study. Food Chem Toxicol; 2009 Jan;47(1):184-91
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  • Histopathologically, karyomegaly and atypical tubules/hyperplasias, as well as renal cell adenomas and carcinomas were significantly increased in treated groups of both sexes with dose-dependence.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Animals. Carcinoma / chemically induced. Carcinoma / pathology. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Kidney / pathology. Liver / pathology. Lymph Nodes / pathology. Male. Rats. Rats, Inbred F344. Sex Characteristics

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  • [ErratumIn] Food Chem Toxicol. 2009 Jun;47(6):1400
  • (PMID = 19032970.001).
  • [ISSN] 1873-6351
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Food Additives; 0 / Plant Extracts; 0 / madder color
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90. Sundaram SS, Gomez M, Harindra V: An unusual case of vulval lump: tumour of anogenital mammary-like glands. Int J STD AIDS; 2009 Jan;20(1):61-2
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  • Our case highlights the importance of having a low threshold for biopsy of atypical vulval lesions.
  • [MeSH-major] Adenoma / pathology. Mammary Glands, Human / pathology. Vulva / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19103898.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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91. Bonanomi G, Mandalà L, Maruzzelli L: Laparoscopic staged adjustable gastric banding and liver resection in morbidly obese patient. Obes Surg; 2010 Aug;20(8):1186-90
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  • The intraoperative biopsy was suggestive for a benign lesion of hepatocellular origin but could not make the differential diagnosis between focal nodular hyperplasia and adenoma.
  • The neoplasm had atypical features on postoperative magnetic resonance imaging and was suggestive of liver adenoma.
  • Atypical liver neoplasms are subject to potential degeneration, rupture, and bleeding; therefore, they should be treated surgically to allow final diagnosis and potential cure of the disease.

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  • (PMID = 18830783.001).
  • [ISSN] 1708-0428
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Xing B, Deng K, Ren ZY, Su CB, Wang RZ, Yang Y, Ma WB, Li YN: Magnetic resonance imaging characteristics and surgical results of adrenocorticotropin-secreting pituitary adenomas. Chin Med Sci J; 2008 Mar;23(1):44-8
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  • RESULTS: Preoperative MRI revealed normal results in 41 (15.4%) cases, microadenoma in 179 (67.3%), macroadenoma in 42 (15.8%), and huge adenoma in 4 (1.5%).
  • Preoperative endocrinological tests of 199 cases supported the diagnosis of typical Cushing's disease, while the other 67 cases had atypical endocrinological results.

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  • (PMID = 18437910.001).
  • [ISSN] 1001-9294
  • [Journal-full-title] Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
  • [ISO-abbreviation] Chin. Med. Sci. J.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone
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93. Merritt JL 2nd, Davis DM, Pittelkow MR, Babovic-Vuksanovic D: Extensive acrochordons and pancreatic islet-cell tumors in tuberous sclerosis associated with TSC2 mutations. Am J Med Genet A; 2006 Aug 1;140(15):1669-72
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  • Acrochordons are a common skin lesion, but when presenting in an atypical manner or unusual number may be a sign of TSC and underlying occult pathology thereby warranting evaluation of TSC2.
  • [MeSH-major] Adenoma, Islet Cell / genetics. Adenoma, Islet Cell / pathology. Mutation. Pancreatic Neoplasms / genetics. Pancreatic Neoplasms / pathology. Skin Diseases / genetics. Tuberous Sclerosis / genetics. Tumor Suppressor Proteins / genetics


94. Osawa N, Onoda N, Kawajiri H, Tezuka K, Takashima T, Ishikawa T, Miyauchi A, Hirokawa M, Wakasa K, Hirakawa K: Diagnosis of parathyroid carcinoma using immunohistochemical staining against hTERT. Int J Mol Med; 2009 Dec;24(6):733-41
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  • The differential diagnosis of parathyroid carcinoma from benign adenoma is often difficult when its typical clinicopathological features are absent, even with the aid of various molecular markers.
  • In contrast, one atypical adenoma stained positively and homogeneously, and the disease recurred three times clinically.

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  • (PMID = 19885612.001).
  • [ISSN] 1791-244X
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Phosphoproteins; 0 / RNA-Binding Proteins; 0 / nucleolin; EC 2.7.7.49 / Telomerase
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95. Cetani F, Ambrogini E, Viacava P, Pardi E, Fanelli G, Naccarato AG, Borsari S, Lemmi M, Berti P, Miccoli P, Pinchera A, Marcocci C: Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma? Eur J Endocrinol; 2007 May;156(5):547-54
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  • DESIGN AND PATIENTS: We performed parafibromin and cyclin D1 immunostaining and HRPT2 gene analysis using loss of heterozygosity studies and sequencing analysis in parathyroid specimens from 11 patients with carcinoma (eleven primary tumors, one skin, and four lung metastases), 22 with sporadic adenomas, and 4 with atypical adenomas.
  • Two atypical adenomas were positive and two negative with parafibromin staining.

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  • (PMID = 17468190.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Proteins; 136601-57-5 / Cyclin D1
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96. Nakanishi K, Kumaki F, Hiroi S, Mukai M, Ikeda E, Kawai T: Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Arch Pathol Lab Med; 2006 Sep;130(9):1330-4
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  • [Title] Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  • OBJECTIVE: To investigate Mre11 in atypical adenomatous hyperplasia (AAH) and nonmucinous bronchioloalveolar carcinoma (NMBAC), an issue not previously explored.
  • CONCLUSIONS: On this basis, we suggest that the part played by Mre11 in telomere maintenance may not be important for the progression of the adenoma-carcinoma (AAH-NMBAC) sequence in the lung, although some role for it in carcinogenesis cannot be completely ruled out.

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  • (PMID = 16948520.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / MRE11A protein, human; 0 / RNA, Messenger
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97. Fulciniti F, Losito NS, Botti G, Manola M, Ionna F: Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample. Diagn Cytopathol; 2010 Jun;38(6):430-4
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  • [Title] Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.
  • One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy.
  • The cytopathologic picture showed a quizzical mixture of necrosis and inflammation coupled to hyperplastic changes of the acinar cells, oncocytic metaplasia, and atypical squamous metaplasia of extreme degree simulating high-grade epidermoid- or mucoepidermoid carcinoma.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Adenoma, Pleomorphic / pathology. Infarction / pathology. Parotid Neoplasms / blood supply. Parotid Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19894261.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Jass JR: Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat Clin Pract Oncol; 2005 Aug;2(8):398-405
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  • [Title] Serrated adenoma of the colorectum and the DNA-methylator phenotype.
  • HP and SA are related lesions and there is now strong evidence for a 'serrated-polyp pathway' to colorectal cancer (CRC) that is largely independent of the classic adenoma-to-carcinoma sequence.
  • A recently recognized lesion in this pathway is a HP variant characterized by relatively large size, atypical histology and proximal location in the colorectum.
  • Because this lesion lacks the traditional cytology of colorectal adenoma and in order to avoid confusion with SA, it is referred to in this review as sessile serrated polyp.
  • [MeSH-major] Adenoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA Methylation


99. Kajor M, Ziaja J, Król R, Ciupińska-Kajor M, Dobrosz Z, Heitzman M, Cierpka L: [Analysis of adrenocortical tumors morphology as regards their structure and potential malignancy]. Endokrynol Pol; 2006 Mar-Apr;57(2):136-42
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  • RESULTS: In routine histopatological examination ACC was diagnosed in 6 tumours (5.4%), adrenocortical adenoma (ACA) in 92 (83.6%) and adrenocortical hyperplasia in 12 (10.9%).
  • Nuclear grade III or IV was observed in 8 tumours (7.3%), mitotic rate > 5/50 high power fields in 6 (5.4%), atypical mitoses in 5 (4.5%), clear cells constituting < 25% of the tumour in 10 (9.1%), diffuse architecture in 8 (7.3%), necrosis in 16 (14.5%), veins infiltration in 4 (3.6%), sinusoids infiltration in 7 (6.3%), and tumour capsule infiltration in 5 (4.5%).
  • CONCLUSION: The structure and cell arrangement in adrenocortical adenoma are heterogeneous.
  • Application of criteria proposed by Weiss in histopathological examination of adrenocortical tumours can be useful in differentiating adrenocortical adenoma from carcinoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / ultrastructure. Adrenocortical Adenoma / ultrastructure. Adrenocortical Carcinoma / ultrastructure. Biomarkers, Tumor / analysis. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / ultrastructure

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  • (PMID = 16773589.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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100. Angadi PV, Rekha K, Shetty SR: "An exophytic mandibular brown tumor": an unusual presentation of primary hyperparathyroidism. Oral Maxillofac Surg; 2010 Mar;14(1):67-9
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  • CASE REPORT: A case of 35-year-old male patient with previously undiagnosed primary hyperparathyroidism who presented with an atypical exophytic mandibular swelling is reported.
  • [MeSH-major] Adenoma / diagnosis. Hyperparathyroidism, Primary / diagnosis. Magnetic Resonance Imaging. Mandibular Diseases / diagnosis. Osteitis Fibrosa Cystica / diagnosis. Parathyroid Neoplasms / diagnosis. Radiography, Panoramic

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  • (PMID = 19943073.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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