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1
astrocytomas grade iii 2005:2010[pubdate] *count=100
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Items 1 to 100 of about 753
1.
Adam Y, Benezech J, Blanquet A, Fuentes JM, Bousigue JY, Debono B, Duplessis E, Espagno C, Plas JY, Lescure JP, Destandau J, Hladky JP, Grunewald P, Mahla K, Remond J, Louis E:
[Intramedullary tumors. Results of a national investigation in private neurosurgery].
Neurochirurgie
; 2010 Aug;56(4):344-9
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MATERIAL: Seventy-nine cases were distributed in the following manner: ependymomas, 38;
astrocytomas
, 22; oligodendrogliomas, four; gangliogliomas, two; hemangioblastomas, 10 (nine sporadic cases and one case of Von Hippel-Lindau disease); primitive melanoma, one; and intramedullary neurinomas, two.
Tumor
removal was complete in the cases of ependymoma and hemangioblastoma and subtotal in the cases of
astrocytoma
.
Astrocytomas
: 22 cases, with 14 cases of
astrocytoma
, two pilocytic
astrocytoma
, four
malignant astrocytoma
, and two glioblastoma.
Diagnostic delay:
malignant
tumors, one to nine months; low grades; three to six years (range, eight months to 25 years).
[MeSH-minor]
Adolescent. Adult. Aged. Delayed Diagnosis. Female. Follow-Up Studies. France / epidemiology. Humans. Magnetic Resonance Imaging. Male. Microsurgery. Middle Aged.
Neoplasm
Recurrence, Local. Neurosurgical Procedures. Treatment Outcome. Young Adult
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[Copyright]
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
(PMID = 20097390.001).
[ISSN]
1773-0619
[Journal-full-title]
Neuro-Chirurgie
[ISO-abbreviation]
Neurochirurgie
[Language]
fre
[Publication-type]
English Abstract; Journal Article
[Publication-country]
France
2.
Hernández-Hernández OT, RodrÃguez-Dorantes M, González-Arenas A, Camacho-Arroyo I:
Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines.
Endocrine
; 2010 Feb;37(1):194-200
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[Title]
Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human
astrocytoma
cell lines.
In this study, we determined progesterone and estrogen receptor isoform expression in two human
astrocytoma
cell lines with different evolution
grade
(U373,
grade III
; and D54,
grade
IV) by Western Blot.
Our data suggest that SRC-1 and SRC-3 expression is differentially regulated by sex steroid hormones in
astrocytomas
and that P(4) regulates SRC-1 expression depending on the evolution
grade
of human
astrocytoma
cells.
[MeSH-major]
Astrocytoma
/ metabolism. Estradiol / metabolism. Gene Expression Regulation, Neoplastic. Glioblastoma / metabolism. Nuclear Receptor Coactivator 1 / metabolism. Nuclear Receptor Coactivator 3 / metabolism. Progesterone / metabolism
[MeSH-minor]
Blotting, Western. Cell Line,
Tumor
. Humans. Protein Isoforms / metabolism. RNA, Messenger / metabolism. Receptors, Estradiol / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Time Factors
Hazardous Substances Data Bank.
ESTRADIOL
.
Hazardous Substances Data Bank.
PROGESTERONE
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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(PMID = 20963570.001).
[ISSN]
1559-0100
[Journal-full-title]
Endocrine
[ISO-abbreviation]
Endocrine
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Protein Isoforms; 0 / RNA, Messenger; 0 / Receptors, Estradiol; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 4G7DS2Q64Y / Progesterone; 4TI98Z838E / Estradiol; EC 2.3.1.48 / NCOA1 protein, human; EC 2.3.1.48 / NCOA3 protein, human; EC 2.3.1.48 / Nuclear Receptor Coactivator 1; EC 2.3.1.48 / Nuclear Receptor Coactivator 3
3.
Elsir T, Eriksson A, Orrego A, Lindström MS, Nistér M:
Expression of PROX1 Is a common feature of high-grade malignant astrocytic gliomas.
J Neuropathol Exp Neurol
; 2010 Feb;69(2):129-38
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[Title]
Expression of PROX1 Is a common feature of high-
grade
malignant astrocytic
gliomas.
PROX1 is a prospero-related transcription factor that plays a critical role in the development of various organs including the mammalian lymphatic and central nervous systems; it controls cell proliferation and differentiation through different transcription pathwaysand has both oncogenic and
tumor
-suppressive functions.
We investigated PROX1 expression patterns in 56 human
astrocytic
gliomas of different grades using immunohistochemistry.
An average of 79% of cells in World Health Organization
Grade
IV (glioblastoma, n = 15) and 57% of cells in World Health Organization
Grade III
(
anaplastic astrocytoma
, n = 13) were strongly PROX1 positive; low-
grade
diffuse
astrocytomas
(
Grade
II, n = 13) had 21% of cells that were strongly positive;
Grade
I tumors (n = 15) had 1.5%; and non-neoplastic brain tissue (n = 15) had 3.7% of cells that were PROX1 positive.
Analyses of coexpression with proliferation markers suggest that PROX1+ cells have a marginally lower rate of proliferation than other
tumor
cells but are still mitotically active.
We conclude that PROX1 may constitute a useful tool for the diagnosis and grading ofastrocytic gliomas and for distinguishing
Grade III
and
Grade
IV tumors from
Grade
I and
Grade
II tumors.
[MeSH-major]
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Homeodomain Proteins / metabolism.
Tumor
Suppressor Proteins / metabolism
MedlinePlus Health Information.
consumer health - Brain Tumors
.
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(PMID = 20084020.001).
[ISSN]
1554-6578
[Journal-full-title]
Journal of neuropathology and experimental neurology
[ISO-abbreviation]
J. Neuropathol. Exp. Neurol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Nuclear; 0 / Biomarkers; 0 / Homeodomain Proteins; 0 / MAP2 protein, human; 0 / Microtubule-Associated Proteins; 0 / Nerve Tissue Proteins; 0 / Tubulin; 0 / Tumor Suppressor Proteins; 0 / neuronal nuclear antigen NeuN, human; 0 / prospero-related homeobox 1 protein
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4.
Shirai K, Suzuki Y, Okamoto M, Wakatsuki M, Noda SE, Takahashi T, Ishiuchi S, Hasegawa M, Nakazato Y, Nakano T:
Influence of histological subtype on survival after combined therapy of surgery and radiation in WHO grade 3 glioma.
J Radiat Res
; 2010;51(5):589-94
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[Title]
Influence of histological subtype on survival after combined therapy of surgery and radiation in WHO
grade
3 glioma.
World Health Organization (WHO)
grade
3 glioma is one of the common brain tumors and has three main histological subtypes, including
anaplastic astrocytoma
(AA),
anaplastic
oligoastrocytoma (AOA) and
anaplastic
oligodendroglioma (AO).
In this study, 68 patients with histologically proven WHO
grade
3 glioma, consecutively received postoperative radiotherapy at the Gunma University Hospital, Japan, between 1983 and 2005, were investigated to assess the impact of histological subtype on the survival.
In our study, histological subtype was one of the most important prognostic factors of WHO
grade
3 glioma.
[MeSH-major]
Astrocytoma
/ radiotherapy. Brain Neoplasms / radiotherapy. Glioma / radiotherapy. Oligodendroglioma / radiotherapy
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(PMID = 20921826.001).
[ISSN]
1349-9157
[Journal-full-title]
Journal of radiation research
[ISO-abbreviation]
J. Radiat. Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Japan
5.
Faria MH, Khayat AS, Burbano RR, Rabenhorst SH:
c -MYC amplification and expression in astrocytic tumors.
Acta Neuropathol
; 2008 Jul;116(1):87-95
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[Title]
c -MYC amplification and expression in
astrocytic
tumors.
The aim of this study was to evaluate the nuclear and cytoplasmic expression of c-MYC protein in human
astrocytic
tumors of different histopathological grades and to determine whether its expression correlates with c-MYC gene amplification.
An immunohistochemical study of c-MYC protein was performed in 140 paraffin-embedded
astrocytic
tumors of different grades.
The distribution of the positive cases according to the
tumor
grade
increased in both nuclear and cytoplasmic staining with malignancy.
The median nuclear LI also increased with
tumor
grade
, with highest c-MYC nuclear expression in
grade III
.
The median cytoplasmic labeling scores showed a significant difference between
grade
I tumors and diffuse tumors, which presented high and similar median scores.
FISH results disclosed that the presence of two signals was inversely correlated with histopathological
grade
, while the presence of >/=5 signals increased according to degree of malignancy.
These results indicate that c-MYC expression in
astrocytic
tumors is strongly associated with increased c-MYC gene copy number and suggest that c-MYC plays a role in the early tumorigenesis of
astrocytomas
.
[MeSH-major]
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Genes, myc
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(PMID = 18369647.001).
[ISSN]
0001-6322
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
6.
Chamberlain MC, Wei-Tsao DD, Blumenthal DT, Glantz MJ:
Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory anaplastic astrocytoma.
Cancer
; 2008 May 1;112(9):2038-45
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[Title]
Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory
anaplastic astrocytoma
.
BACKGROUND: The primary objective of this prospective phase 2 study of CPT-11 in adult patients with recurrent temozolomide-refractory
anaplastic astrocytoma
(AA) was to evaluate 6-month progression-free survival (PFS).
The median time to
tumor
progression was 4.1 month.
[MeSH-major]
Antineoplastic Agents / therapeutic use.
Astrocytoma
/ drug therapy. Brain Neoplasms / drug therapy. Camptothecin / analogs & derivatives. Dacarbazine / analogs & derivatives.
Neoplasm
Recurrence, Local / drug therapy. Salvage Therapy / methods
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.
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.
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.
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DACARBAZINE
.
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(PMID = 18361434.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 7673326042 / irinotecan; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; XT3Z54Z28A / Camptothecin
7.
Lustig RA, Seiferheld W, Berkey B, Yung AW, Scarantino C, Movsas B, Jones CU, Simpson JR, Fishbach J, Curran WJ Jr:
Imaging response in malignant glioma, RTOG 90-06.
Am J Clin Oncol
; 2007 Feb;30(1):32-7
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[Title]
Imaging response in
malignant
glioma, RTOG 90-06.
OBJECTIVE: The purpose of this study was to determine if radiographic response correlates with survival for patients treated patients with
malignant
gliomas treated on Radiation Therapy Oncology Group (RTOG) protocol 90-06.
Histology included
anaplastic astrocytoma
(60) (AA), and glioblastoma multiforme (312) (GBM).
RESULTS: For patients with no
tumor
on the 4 month scan the median survival was 20.3 months and the 2 year survival 43%.
[MeSH-minor]
Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ drug therapy.
Astrocytoma
/ pathology.
Astrocytoma
/ radiography.
Astrocytoma
/ radiotherapy. Biopsy. Brain Neoplasms / drug therapy. Brain Neoplasms / mortality. Brain Neoplasms / pathology. Brain Neoplasms / radiography. Brain Neoplasms / radiotherapy. Carmustine / administration & dosage. Carmustine / therapeutic use. Disease Progression. Female. Glioblastoma / drug therapy. Glioblastoma / pathology. Glioblastoma / radiography. Glioblastoma / radiotherapy. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Survival Analysis. Tomography, X-Ray Computed
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(PMID = 17278892.001).
[ISSN]
1537-453X
[Journal-full-title]
American journal of clinical oncology
[ISO-abbreviation]
Am. J. Clin. Oncol.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / U10 CA 32115; United States / NCI NIH HHS / CA / U10 CA21661; United States / NCI NIH HHS / CA / U10 CA37422
[Publication-type]
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; U68WG3173Y / Carmustine
8.
Mutter N, Stupp R:
Temozolomide: a milestone in neuro-oncology and beyond?
Expert Rev Anticancer Ther
; 2006 Aug;6(8):1187-204
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Three pivotal Phase II trials showed modest activity in the treatment of recurrent
anaplastic astrocytoma
glioblastoma.
In 2005, the FDA and the European Agency for the Evaluation of Medicinal Products approved temozolomide for use in newly diagnosed glioblastoma, in conjunction with radiotherapy, based on an European Organisation for Research and Treatment of Cancer/National Cancer Institute of Canada Phase
III
trial.
Temozolomide is under investigation for other disease entities, in particular lower-
grade
glioma, brain metastases and melanoma.
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.
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.
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.
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.
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(PMID = 16925485.001).
[ISSN]
1744-8328
[Journal-full-title]
Expert review of anticancer therapy
[ISO-abbreviation]
Expert Rev Anticancer Ther
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
[Number-of-references]
143
9.
Attenello FJ, Mukherjee D, Datoo G, McGirt MJ, Bohan E, Weingart JD, Olivi A, Quinones-Hinojosa A, Brem H:
Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience.
Ann Surg Oncol
; 2008 Oct;15(10):2887-93
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[Title]
Use of Gliadel (BCNU) wafer in the surgical treatment of
malignant
glioma: a 10-year institutional experience.
BACKGROUND: Gliadel (polifeprosan 20 with carmustine [BCNU] implant) is commonly used for local delivery of BCNU to high-
grade
gliomas after resection and is associated with increased survival.
We set out to characterize Gliadel-associated morbidity in our 10-year experience with Gliadel wafers for treatment of
malignant
glioma.
METHODS: We retrospectively reviewed records of 1013 patients undergoing craniotomy for resection of
malignant
brain
astrocytoma
(World Health Organization
grade III
/IV disease).
RESULTS: A total of 1013 craniotomies were performed for
malignant
brain
astrocytoma
.
A total of 288 (28%) received Gliadel wafer (250 glioblastoma multiforme (GBM), 38
anaplastic astrocytoma
/
anaplastic
oligodendroglioma (AA/AO), 166 primary resection, 122 revision resection).
Patients in Gliadel versus non-Gliadel cohorts had similar incidences of perioperative surgical site infection (2.8% vs. 1.8%, P = .33), cerebrospinal fluid leak (2.8% vs. 1.8%, P = .33), meninigitis (.3% vs. .3%, P = 1.00), incisional wound healing difficulty (.7% vs. .4%, P = .63), symptomatic
malignant
edema (2.1% vs. 2.3%, P = 1.00), 3-month seizure incidence (14.6% vs. 15.7%, P = .65), deep-vein thrombosis (6.3% vs. 5.2%, P = .53), and pulmonary embolism (PE) (4.9% vs. 3.7%, P = .41).
CONCLUSION: In our experience, use of Gliadel wafer was not associated with an increase in perioperative morbidity after surgical treatment of
malignant astrocytoma
.
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(PMID = 18636295.001).
[ISSN]
1534-4681
[Journal-full-title]
Annals of surgical oncology
[ISO-abbreviation]
Ann. Surg. Oncol.
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0 / Biocompatible Materials; 0 / Decanoic Acids; 0 / Drug Carriers; 0 / Polyesters; 90409-78-2 / decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer; U68WG3173Y / Carmustine
10.
Braun K, Wiessler M, Ehemann V, Pipkorn R, Spring H, Debus J, Didinger B, Koch M, Muller G, Waldeck W:
Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistry.
Drug Des Devel Ther
; 2009;2:289-301
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Temozolomide (TMZ) was approved for second-line therapy of recurrent
anaplastic astrocytoma
.
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[ISSN]
1177-8881
[Journal-full-title]
Drug design, development and therapy
[ISO-abbreviation]
Drug Des Devel Ther
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
New Zealand
[Other-IDs]
NLM/ PMC2761188
[Keywords]
NOTNLM ; carrier molecules / drug delivery / facilitated transport / glioblastoma multiforme / temozolomide
11.
Hayatsu N, Kaneko MK, Mishima K, Nishikawa R, Matsutani M, Price JE, Kato Y:
Podocalyxin expression in malignant astrocytic tumors.
Biochem Biophys Res Commun
; 2008 Sep 19;374(2):394-8
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[Title]
Podocalyxin expression in
malignant astrocytic
tumors.
Recently, we revealed that highly sulfated KS or another mucin-like transmembrane sialoglycoprotein podoplanin/aggrus is upregulated in
malignant astrocytic
tumors.
The aim of this study is to examine the relationship between podocalyxin expression and
malignant
progression of
astrocytic
tumors.
In this study, 51
astrocytic
tumors were investigated for podocalyxin expression using immunohistochemistry, Western blot analysis, and quantitative real-time PCR.
Immunohistochemistry detected podocalyxin on the surface of
tumor
cells in six of 14
anaplastic
astrocytomas
(42.9%) and in 17 of 31 glioblastomas (54.8%), especially around proliferating endothelial cells.
In diffuse
astrocytoma
, podocalyxin expression was observed only in vascular endothelial cells.
Podocalyxin might be associated with the
malignant
progression of
astrocytic
tumors, and be a useful prognostic marker for
astrocytic
tumors.
[MeSH-major]
Astrocytoma
/ pathology. Biomarkers,
Tumor
/ analysis. Central Nervous System Neoplasms / pathology. Sialoglycoproteins / analysis
[MeSH-minor]
Blotting, Western. Humans. Immunohistochemistry. Polymerase Chain Reaction. Prognosis. RNA, Messenger / analysis. RNA, Messenger / biosynthesis. RNA, Messenger / genetics.
Tumor
Cells, Cultured
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(PMID = 18639524.001).
[ISSN]
1090-2104
[Journal-full-title]
Biochemical and biophysical research communications
[ISO-abbreviation]
Biochem. Biophys. Res. Commun.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Sialoglycoproteins; 0 / podocalyxin
12.
Schenka AA, Machado CM, Grippo MC, Queiroz LS, Schenka NG, Chagas CA, Verinaud L, Brousset P, Vassallo J:
Immunophenotypic and ultrastructural validation of a new human glioblastoma cell line.
Cell Mol Neurobiol
; 2005 Aug;25(5):929-41
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1. A human glioma cell line, NG97, was established by Grippo et al. in 2001 from tissue obtained from a
grade III
astrocytoma
(WHO, 2000).
The injection of NG97 cells into nude mice induced an aggressive
tumor
characterized by: severe cytological atypia, vascular proliferation and pseudopalisading necrosis (glioblastoma multiforme features).
2. The purpose of the present study was to characterize the immunophenotype and ultrastructural aspects of this cell line, using the parental
tumor
, cultured cells and the xenotransplant, in order to assess its glial nature and possible divergent differentiation.
GFAP was similarly expressed in the parental
tumor
and in the cells in culture, but decreased in the xenotransplant.
The xenotransplant's ultrastructural features were those of a highly undifferentiated
tumor
.
4. Thus, our data demonstrate that NG97 cells constitute a pure glial-committed cell line, which may prove useful as
a malignant
glioma model in studies addressing pathophysiological, diagnostic and therapeutic issues.
[MeSH-major]
Brain Neoplasms / pathology. Cell Culture Techniques / standards. Cell Line,
Tumor
. Glioblastoma / pathology
[MeSH-minor]
Animals. Biomarkers. Cell Differentiation. Humans. Immunophenotyping. Mice. Mice, Nude. Microscopy, Electron.
Neoplasm
Transplantation. Neuroglia / cytology. Reproducibility of Results. Transplantation, Heterologous
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]
[Cites]
J Neurooncol. 1996 Feb;27(2):141-7
[
8699236.001
]
[Cites]
Braz J Med Biol Res. 1998 Oct;31(10):1281-4
[
9876299.001
]
[Cites]
Braz J Med Biol Res. 2001 May;34(5):653-61
[
11323753.001
]
(PMID = 16133944.001).
[ISSN]
0272-4340
[Journal-full-title]
Cellular and molecular neurobiology
[ISO-abbreviation]
Cell. Mol. Neurobiol.
[Language]
eng
[Publication-type]
Journal Article; Validation Studies
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers
13.
Phi JH, Chung CK:
Brain tumors in the mesial temporal lobe: long-term oncological outcome.
Neurosurg Focus
; 2009 Aug;27(2):E5
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METHODS: Thirty-six patients with an MTL
tumor
were studied.
The tumors were confined to the MTL (Schramm
Type A
) in 25 patients (69%).
Extension of the
tumor
into the fusiform gyrus (Schramm
Type
C) and temporal stem (Schramm
Type
D) was observed in 4 and 7 patients (11 and 19%), respectively.
There was a significant difference in the
tumor
size according to Schramm types (p = 0.001).
Complete
tumor
resection was achieved in 26 patients (72%).
All tumors were low-
grade
lesions except for 1
anaplastic astrocytoma
.
The degree of
tumor
resection was significantly related to the
tumor
control failure (p < 0.001) and
malignant
transformation of a low-
grade
tumor
(p < 0.001).
Univariate analyses using a Cox proportional hazards model showed that the following factors were significantly associated with a failure to control the
tumor
:.
1) extent of the
tumor
(Schramm
Type
D; p = 0.003, relative risk [RR] 12.04);.
2) size of the
tumor
(p = 0.033, RR 1.052/mm);.
Complete
tumor
resection is strongly recommended for long-term
tumor
control.
Older age, short duration of epilepsy, and
tumor
size are all associated with poor outcome.
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(PMID = 19645561.001).
[ISSN]
1092-0684
[Journal-full-title]
Neurosurgical focus
[ISO-abbreviation]
Neurosurg Focus
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
14.
Ashley DM, Riffkin CD, Muscat AM, Knight MJ, Kaye AH, Novak U, Hawkins CJ:
Caspase 8 is absent or low in many ex vivo gliomas.
Cancer
; 2005 Oct 1;104(7):1487-96
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BACKGROUND: Better treatments are required urgently for patients with
malignant
glioma, which currently is incurable.
Death ligands, such as
tumor
necrosis factor-related apoptosis-inducing ligand (TRAIL), may offer promise for the treatment high-
grade
glioma if such ligands induce apoptotic signaling in vivo in glioma cells.
It also may act as
a tumor
suppressor protein.
METHODS: Eleven glioblastomas, 5
anaplastic
astrocytomas
, and 3 low-
grade astrocytomas
were studied.
[MeSH-major]
Astrocytoma
/ pathology. Biomarkers,
Tumor
/ metabolism. Brain Neoplasms / pathology. Caspases / metabolism. Glioblastoma / pathology
[MeSH-minor]
Base Sequence. Blotting, Northern. Caspase 10. Caspase 8. DNA Methylation. DNA,
Neoplasm
/ analysis. Female. Humans. Male. Molecular Sequence Data. Probability. Reverse Transcriptase Polymerase Chain Reaction / methods. Risk Assessment. Sampling Studies. Sensitivity and Specificity. Statistics, Nonparametric. Tissue Culture Techniques
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(PMID = 16080161.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / CASP10 protein, human; 0 / DNA, Neoplasm; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 10; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases
15.
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD:
IDH1 and IDH2 mutations in gliomas.
N Engl J Med
; 2009 Feb 19;360(8):765-73
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BACKGROUND: A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO]
grade
IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-
grade
gliomas (secondary glioblastomas).
RESULTS: We identified mutations that affected amino acid 132 of IDH1 in more than 70% of WHO
grade
II and
III astrocytomas
and oligodendrogliomas and in glioblastomas that developed from these lower-
grade
lesions.
Tumors with IDH1 or IDH2 mutations had distinctive genetic and clinical characteristics, and patients with such tumors had a better outcome than those with wild-
type
IDH genes.
CONCLUSIONS: Mutations of NADP(+)-dependent isocitrate dehydrogenases encoded by IDH1 and IDH2 occur in a majority of several types of
malignant
gliomas.
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[Copyright]
2009 Massachusetts Medical Society
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N Engl J Med. 2009 Feb 19;360(8):813-5
[
19228626.001
]
(PMID = 19228619.001).
[ISSN]
1533-4406
[Journal-full-title]
The New England journal of medicine
[ISO-abbreviation]
N. Engl. J. Med.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA043460-27; United States / NCI NIH HHS / CA / CA57345; United States / NCI NIH HHS / CA / R01CA118822; United States / NCI NIH HHS / CA / R37 CA043460; United States / NCI NIH HHS / CA / R37 CA043460-27; United States / NCI NIH HHS / CA / P50 CA108786; United States / NINDS NIH HHS / NS / P50 NS020023; United States / NCI NIH HHS / CA / 2P30-CA-14236; United States / NCI NIH HHS / CA / 5P50-CA-108786; United States / NCI NIH HHS / CA / CA121113; United States / NCI NIH HHS / CA / CA062924-150012; United States / NCI NIH HHS / CA / R37 CA043460-26; United States / NCI NIH HHS / CA / 5R37-CA-11898; United States / NCI NIH HHS / CA / R37CA11898-34; United States / NCI NIH HHS / CA / R01 CA121113; United States / NCI NIH HHS / CA / R01 CA140316; United States / NCI NIH HHS / CA / CA43460; United States / NCI NIH HHS / CA / CA043460-26; United States / NCI NIH HHS / CA / R01 CA121113-04; United States / NINDS NIH HHS / NS / NS20023-21; United States / NCI NIH HHS / CA / CA057345-17; United States / NCI NIH HHS / CA / R37 CA057345-17; United States / NCI NIH HHS / CA / R37 CA057345; United States / NCI NIH HHS / CA / P30 CA014236; United States / NCI NIH HHS / CA / P50 CA062924-150012; United States / NCI NIH HHS / CA / R01 CA057345; United States / NCI NIH HHS / CA / R01 CA118822; United States / NINDS NIH HHS / NS / 5P50-NS-20023; United States / NCI NIH HHS / CA / R37 CA011898
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.41 / isocitrate dehydrogenase 2, human
[Other-IDs]
NLM/ NIHMS107443; NLM/ PMC2820383
16.
Kita D, Yonekawa Y, Weller M, Ohgaki H:
PIK3CA alterations in primary (de novo) and secondary glioblastomas.
Acta Neuropathol
; 2007 Mar;113(3):295-302
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[Title]
PIK3CA alterations in primary (
de
novo) and secondary glioblastomas.
We assessed alterations in the EGFR/PTEN/PI3K pathway in 107 primary (
de
novo) glioblastomas and 32 secondary glioblastomas that progressed from low-
grade
or
anaplastic
astrocytomas
.
Furthermore, this signaling pathway was altered by either PTEN mutations or PIK3CA amplification in 10 of 12 (83%)
malignant
glioma cell lines analyzed.
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(PMID = 17235514.001).
[ISSN]
0001-6322
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
17.
Khwaja FW, Reed MS, Olson JJ, Schmotzer BJ, Gillespie GY, Guha A, Groves MD, Kesari S, Pohl J, Van Meir EG:
Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients.
J Proteome Res
; 2007 Feb;6(2):559-70
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[Title]
Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of
astrocytoma
patients.
In this report, we used two proteomic techniques, two-dimensional gel electrophoresis (2-
DE
), and cleavable Isotope-Coded Affinity Tag (cICAT) to compare CSF proteomes to identify
tumor
- and
grade
-specific biomarkers in patients bearing brain tumors of differing histologies and grades.
Retrospective analyses were performed on 60 samples derived from
astrocytomas
WHO
grade
II,
III
, and IV, schwannomas, metastastic brain tumors, inflammatory samples, and non-neoplastic controls.
We identified 103 potential
tumor
-specific markers of which 20 were high-
grade
astrocytoma
-specific.
These investigations allowed us to identify a spectrum of signature proteins that could be used to distinguish CSF derived from control patients versus those with low- (AII) or high-
grade
(AIV)
astrocytoma
.
These candidate biomarkers may also have functional properties that play a critical role in the development and
malignant
progression of human
astrocytomas
, thus possibly representing novel therapeutic targets for this highly lethal disease.
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[ISSN]
1535-3893
[Journal-full-title]
Journal of proteome research
[ISO-abbreviation]
J. Proteome Res.
[Language]
ENG
[Grant]
United States / NCRR NIH HHS / RR / RR 02878; United States / NCI NIH HHS / CA / R01 CA086335; United States / NCI NIH HHS / CA / R01 CA086335-05; United States / NCRR NIH HHS / RR / M01 RR000039; United States / NCRR NIH HHS / RR / RR 12878; United States / NCRR NIH HHS / RR / M01 RR 00039; United States / NCRR NIH HHS / RR / RR 13948; United States / NCI NIH HHS / CA / CA 86335
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Affinity Labels; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / Proteome
[Other-IDs]
NLM/ NIHMS61862; NLM/ PMC2566942
18.
Marton E, Feletti A, Orvieto E, Longatti P:
Malignant progression in pleomorphic xanthoastrocytoma: personal experience and review of the literature.
J Neurol Sci
; 2007 Jan 31;252(2):144-53
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[Title]
Malignant
progression in pleomorphic xanthoastrocytoma: personal experience and review of the literature.
Pleomorphic xanthoastrocytoma (PXA) is a rare primary low-
grade
astrocytic tumor
, recently classified as a neuroglial
tumor
.
It generally occurs in children and young adults and shows benign behaviour (WHO II), although an
anaplastic
variant and
malignant
potential have been described.
Pleomorphic xanthoastrocytomas with
malignant
transformation have been reported in three out of eight patients operated on for this
type
of
tumor
in our department in the last 15 years.
Histological examination revealed simple PXA in two patients and a PXA with
anaplastic
foci in the other.
Mean recurrence time was 5.7 years, with the original xanthoastrocytoma evolving to glioblastoma in two cases and
anaplastic astrocytoma
in the third.
Two died from
tumor
progression and one from brain edema after intracerebral haemorrhage.
A review of the available PXA literature dating back to 1979 revealed 16 cases of primary
anaplastic astrocytoma
and 21 cases of PXA with
malignant
transformation.
Our experience adds three more cases of
malignant
transformations, outlining once again the potential malignancy of pleomorphic xanthoastrocytomas and the fact that prognosis in these cases is the same as for primary
anaplastic astrocytoma
and glioblastoma.
[MeSH-major]
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Glioblastoma / pathology
[MeSH-minor]
Adult. Cell Transformation, Neoplastic. Child. Disease Progression. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Middle Aged.
Neoplasm
Recurrence, Local / pathology. Tomography, X-Ray Computed
Genetic Alliance.
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.
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(PMID = 17189643.001).
[ISSN]
0022-510X
[Journal-full-title]
Journal of the neurological sciences
[ISO-abbreviation]
J. Neurol. Sci.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
Netherlands
[Number-of-references]
52
19.
Murakami R, Sugahara T, Nakamura H, Hirai T, Kitajima M, Hayashida Y, Baba Y, Oya N, Kuratsu J, Yamashita Y:
Malignant supratentorial astrocytoma treated with postoperative radiation therapy: prognostic value of pretreatment quantitative diffusion-weighted MR imaging.
Radiology
; 2007 May;243(2):493-9
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[Title]
Malignant
supratentorial
astrocytoma
treated with postoperative radiation therapy: prognostic value of pretreatment quantitative diffusion-weighted MR imaging.
PURPOSE: To retrospectively evaluate whether the minimum apparent diffusion coefficient (ADC) of the
tumor
seen on pretreatment magnetic resonance (MR) images is of prognostic value in patients with
malignant
supratentorial
astrocytoma
.
Between June 1996 and November 2003, 79 patients (44 male, 35 female; age range, 16-76 years) with
malignant
supratentorial
astrocytoma
underwent pretreatment MR imaging.
Patient age, symptom duration, neurologic function, mental status, Karnofsky performance scale (KPS) score, extent of surgery, histopathologic diagnosis,
tumor
component enhancement, and minimum ADC were assessed at factor analysis of survival.
RESULTS: Twenty-nine patients had
anaplastic astrocytoma
, and 50 had glioblastoma multiforme.
The minimum ADC was significantly lower in patients with glioblastoma multiforme than in those with
anaplastic astrocytoma
(P < .001).
CONCLUSION: The minimum ADC at pretreatment MR imaging is a useful clinical prognostic biomarker for survival in patients with
malignant
supratentorial
astrocytoma
.
[MeSH-major]
Astrocytoma
/ diagnosis. Diffusion Magnetic Resonance Imaging / methods. Radiotherapy, Adjuvant / methods. Supratentorial Neoplasms / diagnosis. Supratentorial Neoplasms / therapy
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(PMID = 17356177.001).
[ISSN]
0033-8419
[Journal-full-title]
Radiology
[ISO-abbreviation]
Radiology
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
United States
20.
Abou-Ghazal M, Yang DS, Qiao W, Reina-Ortiz C, Wei J, Kong LY, Fuller GN, Hiraoka N, Priebe W, Sawaya R, Heimberger AB:
The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas.
Clin Cancer Res
; 2008 Dec 15;14(24):8228-35
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[Title]
The incidence, correlation with
tumor
-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas.
We sought to determine the incidence of phosphorylated STAT3 (p-STAT3) expression in
malignant
gliomas of different pathologic types, whether p-STAT3 expression is a negative prognostic factor, and whether p-STAT3 expression influences the inflammatory response within gliomas.
RESULTS: We did not detect p-STAT3 expression in normal brain tissues or low-
grade astrocytomas
.
We observed significant differences in the incidence of p-STAT3 expression between the different grades of
astrocytomas
and different pathologic glioma types. p-STAT3 expression was associated with the population of
tumor
-infiltrating immune cells but not with that of T regulatory cells.
On univariate analysis, we found that p-STAT3 expression within
anaplastic
astrocytomas
was a negative prognostic factor.
CONCLUSIONS: p-STAT3 expression is common within gliomas of both the
astrocytic
and oligodendroglial lineages and portends poor survival in patients with
anaplastic
astrocytomas
. p-STAT3 expression differs significantly between gliomas of different pathologic types and grades and correlated with the degree of immune infiltration.
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12131365.001
]
(PMID = 19088040.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA120813-01A1; United States / NCI NIH HHS / CA / R01 CA120813; United States / NCI NIH HHS / CA / R01 CA120813-01A1
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / STAT3 Transcription Factor; 0 / STAT3 protein, human
[Other-IDs]
NLM/ NIHMS78715; NLM/ PMC2605668
21.
Guan X, Lai S, Lackey J, Shi J, Techavipoo U, Moulding HD, Flanders AE, Andrews DW:
Revisiting anaplastic astrocytomas II: further characterization of an expansive growth pattern with visually enhanced diffusion tensor imaging.
J Magn Reson Imaging
; 2008 Dec;28(6):1322-36
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[Title]
Revisiting
anaplastic
astrocytomas
II: further characterization of an expansive growth pattern with visually enhanced diffusion tensor imaging.
PURPOSE: To seek to distinguish and visualize the different magnetic resonance imaging (MRI) growth patterns among
malignant
gliomas utilizing visually enhanced diffusion tensor imaging (DTI).
MATERIALS AND METHODS: Nineteen consecutive patients undergoing image-guided resection of a newly diagnosed
malignant
glioma underwent add-on acquisition of DTI data based on an Institutional Review Board (IRB)-approved imaging protocol during preoperative MRI scans for routine intraoperative image guidance.
Tumor
growth patterns were assigned to expansive or mixed/infiltrative classes as described in the companion article (24).
Infiltrating tumors were WHO
Grade
IV
astrocytomas
and all expansive tumors were either WHO
Grade III astrocytomas
or WHO
Grade
II
astrocytomas
.
DTI-based white matter tractography was conducted and the DTI data were fused with anatomical images using an in-house software package we developed to enhance the visualization of the
tumor
/fiber interface.
RESULTS: Out of the 19
tumor
patients studied, 11 had infiltrative tumors and the other 8 had expansive tumors.
While less clear with 2D axial diffusion color maps, visually enhanced 3D reconstructions of the
tumor
/fiber interface successfully corroborated distinctive growth patterns.
This was particularly evident when viewed in 3D video loops of each
tumor
/fiber interface.
CONCLUSION: We have successfully developed software that visually enhances the anatomic details of the
tumor
/fiber interface in patients with
anaplastic
astrocytomas
.
These data support the existence of a subgroup of patients within the WHO
Grade III
classification with expansive tumors and a significantly better prognosis.
[MeSH-major]
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Diffusion Magnetic Resonance Imaging / methods. Image Enhancement / methods. Image Processing, Computer-Assisted
[MeSH-minor]
Adult. Aged. Female. Humans. Imaging, Three-Dimensional. Magnetic Resonance Imaging, Interventional. Male. Middle Aged.
Neoplasm
Staging
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[Copyright]
(c) 2008 Wiley-Liss, Inc.
(PMID = 19025901.001).
[ISSN]
1053-1807
[Journal-full-title]
Journal of magnetic resonance imaging : JMRI
[ISO-abbreviation]
J Magn Reson Imaging
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
22.
Greco Crasto S, Soffietti R, Rudà R, Cassoni P, Ducati A, Davini O, De Lucchi R, Rizzo L:
Diffusion-Weighted Magnetic Resonance Imaging and ADC Maps in the Diagnosis of Intracranial Cystic or Necrotic Lesions. A Retrospective Study on 49 Patients.
Neuroradiol J
; 2007 Dec 31;20(6):666-75
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Eleven tumours (11/44) appeared hyperintense on DWI: eight metastases from lung cancer (mean ADC value 0.86 mm(2)/s, range 0.75-1.2 mm(2)/s), two GBMs (mean 0.7 mm(2)/s, range 0.67-0.76 mm(2)/s) and one
anaplastic astrocytoma
(ADC value 1.24 mm(2)/s).
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(PMID = 24300002.001).
[ISSN]
1971-4009
[Journal-full-title]
The neuroradiology journal
[ISO-abbreviation]
Neuroradiol J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
23.
Gu J, Zhang C, Chen R, Pan J, Wang Y, Ming M, Gui W, Wang D:
Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas.
Eur J Pediatr
; 2009 Jun;168(6):705-10
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Extracellular matrix metalloproteinase inducer (EMMPRIN), a member of the immunoglobulin superfamily, is present on the surface of
tumor
cells where it stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPs).
The intensively positive expression rates of EMMPRIN (22/27) and MMP2 (21/27) in
anaplastic astrocytoma
and glioblastoma tissues were significantly higher than those in normal brain and low-
grade
astrocytoma
tissues (2/28 and (1/2)8, respectively).
The positive expression of EMMPRIN and MMP2 was associated with higher
grade
gliomas.
[MeSH-major]
Antigens, CD147 / metabolism.
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Brain Neoplasms / mortality. Matrix Metalloproteinase 2 / metabolism
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(PMID = 18795327.001).
[ISSN]
1432-1076
[Journal-full-title]
European journal of pediatrics
[ISO-abbreviation]
Eur. J. Pediatr.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / BSG protein, human; 136894-56-9 / Antigens, CD147; EC 3.4.24.24 / Matrix Metalloproteinase 2
24.
Nakagawa Y, Kageji T, Mizobuchi Y, Kumada H, Nakagawa Y:
Clinical results of BNCT for malignant brain tumors in children.
Appl Radiat Isot
; 2009 Jul;67(7-8 Suppl):S27-30
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[Title]
Clinical results of BNCT for
malignant
brain tumors in children.
It is very difficult to treat the patients with
malignant
brain
tumor
in children, especially under 3 years, because the conventional irradiation cannot be applied due to the damage of normal brain tissue.
However, boron neutron capture therapy (BNCT) has
tumor
selectivity such that it can make damage only in
tumor
cells.
We evaluated the clinical results and courses in patients with
malignant
glioma under 15 years.
There were 3 glioblastomas (GBM), 6
anaplastic
astrocytomas
(AAS), 7 primitive neuroectodermal tumors (PNET), 6 pontine gliomas and 1
anaplastic
ependymoma.
All GBM and PNET patients died due to CSF and/or CNS dissemination without local
tumor
regrowth.
All pontine glioma patients died due to regrowth of the
tumor
.
Four of 6
anaplastic astrocytoma
and 1
anaplastic
ependymoma patients alive without
tumor
recurrence.
BNCT can be applied to
malignant
brain tumors in children, especially under 3 years instead of conventional radiation.
[MeSH-minor]
Adolescent.
Astrocytoma
/ pathology.
Astrocytoma
/ radiotherapy. Child. Child, Preschool. Ependymoma / pathology. Ependymoma / radiotherapy. Fatal Outcome. Female. Glioblastoma / pathology. Glioblastoma / radiotherapy. Humans. Infant. Magnetic Resonance Angiography. Magnetic Resonance Imaging. Male.
Neoplasm
Invasiveness / pathology. Neuroectodermal Tumors, Primitive / pathology. Neuroectodermal Tumors, Primitive / radiotherapy
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(PMID = 19406652.001).
[ISSN]
1872-9800
[Journal-full-title]
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
[ISO-abbreviation]
Appl Radiat Isot
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
25.
Ren ZP, Olofsson T, Qu M, Hesselager G, Soussi T, Kalimo H, Smits A, Nistér M:
Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors.
J Neuropathol Exp Neurol
; 2007 Oct;66(10):944-54
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[Title]
Molecular genetic analysis of p53 intratumoral heterogeneity in human
astrocytic
brain tumors.
We investigated genetic heterogeneity of
astrocytic
gliomas using p53 gene mutations as a marker.
Different parts of morphologically heterogeneous
astrocytic
gliomas were microdissected, and direct DNA sequencing of p53 gene exons 5 through 8 was performed.
Thirty-five glioma samples and
tumor
-adjacent normal-appearing brain tissue from 11 patients were analyzed.
The mutations were present in
grade
II,
III
, and IV
astrocytic
glioma areas.
Both severe functionally dead mutants and mutants with remaining transcriptional activity could be observed in the same
tumor
.
Coexistence of p53 gene mutations and the locus of heterozygosity was common, at least in
astrocytomas grade III
and in glioblastomas, and also occurred in
astrocytoma
grade
II areas.
[MeSH-major]
Astrocytoma
/ genetics. Brain Neoplasms / genetics. Genes, p53 / genetics
[MeSH-minor]
Adult. Aged. DNA Primers. DNA,
Neoplasm
/ genetics. Female. Gene Frequency. Humans. Immunohistochemistry. Loss of Heterozygosity. Male. Microdissection. Middle Aged. Mutation / genetics. Mutation / physiology. Reverse Transcriptase Polymerase Chain Reaction
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(PMID = 17917588.001).
[ISSN]
0022-3069
[Journal-full-title]
Journal of neuropathology and experimental neurology
[ISO-abbreviation]
J. Neuropathol. Exp. Neurol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA Primers; 0 / DNA, Neoplasm
26.
Tuominen H, Lohi J, Maiche A, Törmänen J, Baumann P:
Mediastinal metastasis of glioblastoma multiforme evolving from anaplastic astrocytoma.
J Neurooncol
; 2005 Nov;75(2):225-6
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[Title]
Mediastinal metastasis of glioblastoma multiforme evolving from
anaplastic astrocytoma
.
[MeSH-major]
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Glioblastoma / pathology. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / secondary
[MeSH-minor]
Adult. Disease Progression. Fatal Outcome. Follow-Up Studies. Gene Deletion. Genes, p16. Glial Fibrillary Acidic Protein / metabolism. Homozygote. Humans. Male.
Neoplasm
Recurrence, Local / genetics.
Neoplasm
Recurrence, Local / pathology.
Neoplasm
Recurrence, Local / radiotherapy. Salvage Therapy. Survival Analysis. Time Factors. Tomography, X-Ray Computed
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6985826.001
]
[Cites]
J Am Acad Dermatol. 2002 Feb;46(2):297-300
[
11807444.001
]
[Cites]
J Neurosurg. 1969 Jul;31(1):50-8
[
4307543.001
]
[Cites]
J Neurooncol. 2001 Jun;53(2):107-14
[
11716064.001
]
[Cites]
J Neurosurg. 2000 Nov;93(5):887-90
[
11059674.001
]
(PMID = 16132499.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
United States
[Chemical-registry-number]
0 / Glial Fibrillary Acidic Protein
27.
Simon M, Neuloh G, von Lehe M, Meyer B, Schramm J:
Insular gliomas: the case for surgical management.
J Neurosurg
; 2009 Apr;110(4):685-95
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RESULTS: A > 90% resection was achieved in 42%, and 70-90%
tumor
removal was accomplished in 51% of cases.
For example, in neurologically intact patients < or = 40 years of age with WHO
Grade
I-
III
tumors, good outcomes (Karnofsky Performance Scale Score 80-100) were seen in 91% of cases.
Surprisingly good survival rates were seen after surgery for
anaplastic
gliomas.
The median survival for patients with
anaplastic
astrocytomas
(WHO
Grade III
) was 5 years, and the 5-year survival rate for those with
anaplastic
oligodendroglial tumors was 80%.
Independent predictors of survival included younger age, favorable histological features (WHO
Grade
I and oligodendroglial tumors), YaÅŸargil
Type
5A/B tumors with frontal extensions, and more extensive resections.
CONCLUSIONS: Insular
tumor
surgery carries substantial complication rates.
In view of the oncological benefits of resective surgery, our data would therefore argue for microsurgery as the primary treatment for most patients with a presumed WHO
Grade
I-
III
tumor
.
[MeSH-minor]
Adolescent. Adult. Age Factors. Aged.
Astrocytoma
/ surgery. Child. Female. Humans. Male. Middle Aged. Postoperative Complications. Survival Rate. Treatment Outcome
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(PMID = 19099379.001).
[ISSN]
0022-3085
[Journal-full-title]
Journal of neurosurgery
[ISO-abbreviation]
J. Neurosurg.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
28.
Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki SO, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, Sasaki T:
Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival.
Int J Cancer
; 2008 Aug 15;123(4):787-92
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We quantified Nox4 mRNA expression by real-time PCR in
tumor
specimens from 58 patients with
astrocytomas
and found that the expression levels of Nox4 mRNA in glioblastomas (WHO
grade
IV) were significantly higher than those in other
astrocytomas
(WHO
grade
II and
III
).
[MeSH-minor]
Apoptosis / physiology.
Astrocytoma
/ enzymology.
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Cell Growth Processes / physiology. Cell Line,
Tumor
. Cells, Cultured. Endothelial Cells / metabolism. Endothelial Cells / physiology. Gene Expression. Humans. Immunohistochemistry. RNA Interference. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Transfection
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[Copyright]
(c) 2008 Wiley-Liss, Inc.
(PMID = 18508317.001).
[ISSN]
1097-0215
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / RNA, Messenger; EC 1.6.3.- / NOX4 protein, human; EC 1.6.3.1 / NADPH Oxidase
29.
Mott RT, Murphy BA, Geisinger KR:
Ovarian malignant mixed mesodermal tumor with neuroectodermal differentiation: a multifaceted evaluation.
Int J Gynecol Pathol
; 2010 May;29(3):234-8
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[Title]
Ovarian
malignant
mixed mesodermal
tumor
with neuroectodermal differentiation: a multifaceted evaluation.
Malignant
mixed mesodermal tumors (MMMTs) of the ovary are rare, highly aggressive neoplasms that arise most commonly in postmenopausal women.
Histologically, they consist of a mixed population of
malignant
epithelial and mesenchymal elements.
Histologically, the
tumor
was composed of epithelial, mesenchymal, and neuroectodermal elements.
The neuroectodermal component was predominantly that of a medulloepithelioma, with scattered areas displaying features of an
anaplastic astrocytoma
, including rare ganglion cell differentiation.
DNA ploidy analysis was also performed on the various components of the
tumor
and compared with 3 additional cases of MMMT without neuroectodermal differentiation and 2 ovarian immature teratomas.
Our findings suggest that the neuroectodermal component may arise from a separate clone or at least evolves at an earlier stage of
tumor
development.
[MeSH-major]
Mixed
Tumor
, Mesodermal / pathology. Neuroectodermal Tumors / pathology. Ovarian Neoplasms / pathology
[MeSH-minor]
Aged. Cell Differentiation / physiology. DNA,
Neoplasm
/ genetics. Female. Humans. Immunohistochemistry. Microscopy, Electron, Transmission. Ploidies
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(PMID = 20407321.001).
[ISSN]
1538-7151
[Journal-full-title]
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
[ISO-abbreviation]
Int. J. Gynecol. Pathol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Neoplasm
30.
Giller CA, Berger BD, Pistenmaa DA, Sklar F, Weprin B, Shapiro K, Winick N, Mulne AF, Delp JL, Gilio JP, Gall KP, Dicke KA, Swift D, Sacco D, Harris-Henderson K, Bowers D:
Robotically guided radiosurgery for children.
Pediatr Blood Cancer
; 2005 Sep;45(3):304-10
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Three had pilocytic
astrocytomas
, two had
anaplastic
astrocytomas
, three had ependymomas (two
anaplastic
), four had medulloblastomas, three had atypical teratoid/rhabdoid tumors, three had craniopharyngiomas, and three had other pathologies.
RESULTS: Local control was achieved in the patients with pilocytic and
anaplastic astrocytoma
, three of the patients with medulloblastoma, and the three with craniopharyngioma, but not for those with ependymoma.
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[Copyright]
(c) 2004 Wiley-Liss, Inc.
(PMID = 15558704.001).
[ISSN]
1545-5009
[Journal-full-title]
Pediatric blood & cancer
[ISO-abbreviation]
Pediatr Blood Cancer
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
31.
Quaranta M, Divella R, Daniele A, Di Tardo S, Venneri MT, Lolli I, Troccoli G:
Epidermal growth factor receptor serum levels and prognostic value in malignant gliomas.
Tumori
; 2007 May-Jun;93(3):275-80
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[Title]
Epidermal growth factor receptor serum levels and prognostic value in
malignant
gliomas.
Increased EGFR expression might therefore be a strong prognostic feature in multiple
tumor
types, and inhibition of its cellular actions may have substantial therapeutic benefit.
METHODS AND STUDY DESIGN: Serum samples obtained from 50 healthy individuals and 65 brain cancer patients (35 glioblastoma multiforme and 30
anaplastic
astrocytomas
) were collected before and after treatment and assayed for EGFR extracellular domain serum concentrations by a sandwich ELISA.
There was a significant difference in the mean serum levels of EGFR between glioblastoma multiforme patients (96.2 +/- 12 ng/ml) and
anaplastic astrocytoma
patients (71.6 +/- 18 ng/ml, P = 0.04).
For all patients, median overall survival was 13 months (
anaplastic astrocytoma
, 18 months; glioblastoma multiforme, 12.5 months).
In 47 patients with high EGFR serum levels, overall survival was reduced (P = 0.01), with a median survival time corresponding to 11.5 months (
anaplastic astrocytoma
, 14.5 months; glioblastoma multiforme, 10.5 months).
[MeSH-major]
Biomarkers,
Tumor
/ blood. Brain Neoplasms / blood. Glioma / blood.
Neoplasm
Proteins / blood. Receptor, Epidermal Growth Factor / blood
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ blood.
Astrocytoma
/ drug therapy.
Astrocytoma
/ mortality.
Astrocytoma
/ radiotherapy.
Astrocytoma
/ surgery. Chemotherapy, Adjuvant. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Disease-Free Survival. Enzyme-Linked Immunosorbent Assay. Female. Follow-Up Studies. Glioblastoma / blood. Glioblastoma / drug therapy. Glioblastoma / mortality. Glioblastoma / radiotherapy. Glioblastoma / surgery. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Protein Structure, Tertiary. Radiotherapy, Adjuvant. Signal Transduction. Survival Analysis. Treatment Outcome
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(PMID = 17679463.001).
[ISSN]
0300-8916
[Journal-full-title]
Tumori
[ISO-abbreviation]
Tumori
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 7GR28W0FJI / Dacarbazine; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; YF1K15M17Y / temozolomide
32.
Benesch M, Windelberg M, Sauseng W, Witt V, Fleischhack G, Lackner H, Gadner H, Bode U, Urban C:
Compassionate use of bevacizumab (Avastin) in children and young adults with refractory or recurrent solid tumors.
Ann Oncol
; 2008 Apr;19(4):807-13
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PATIENTS AND METHODS: Fifteen patients (male: n = 8; female: n = 7; median age, 14.6 years) received bevacizumab for recurrent or progressive solid tumors (carcinoma: n = 3; neuroblastoma: n = 2;
astrocytoma
grade III
: n = 2; rhabdomyosarcoma: n = 2; nephroblastoma: n = 2; benign vascular tumors: n = 2; synovial sarcoma: n = 1; and
malignant
hemangiopericytoma: n = 1) on a compassionate basis.
Radiographic objective responses (partial responses) were observed in two patients with
astrocytoma
grade III
and in one patient each with neuroblastoma and pleomorphic rhabdomyosarcoma, respectively.
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(PMID = 18056650.001).
[ISSN]
1569-8041
[Journal-full-title]
Annals of oncology : official journal of the European Society for Medical Oncology
[ISO-abbreviation]
Ann. Oncol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab
33.
Antonelli M, Buttarelli FR, Arcella A, Nobusawa S, Donofrio V, Oghaki H, Giangaspero F:
Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas.
J Neurooncol
; 2010 Sep;99(2):209-15
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[Title]
Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-
grade
gliomas.
The objective of this study was to evaluate, in a series of 43 pediatric high-
grade
gliomas (21
anaplastic astrocytoma
WHO
grade III
and 22 glioblastoma WHO
grade
IV), the prognostic value of histological grading and expression of p53 and YKL-40.
The prognostic stratification for histological grading showed no difference in overall (OS) and progression-free survival (PFS) between glioblastomas and
anaplastic
astrocytomas
.
TP53 mutations were detected in five of 27 (18%) cases (four glioblastomas and one
anaplastic astrocytoma
).
Our results suggest that in pediatric high-
grade
gliomas: (i) histological grading does not have strong prognostic significance, (ii) YKL-40 overexpression is less frequent than adult high-
grade
gliomas and does not correlate with a more aggressive behavior, (
iii
) TP53 mutations but not p53 expression may correlate with a more aggressive behavior, and (iv) IDH1 mutations are absent.
These observations support the concept that, despite identical histological features, the biology of high-
grade
gliomas in children differs from that in adults, and therefore different prognostic factors are needed.
[MeSH-major]
Astrocytoma
/ genetics.
Astrocytoma
/ metabolism. Glycoproteins / metabolism. Isocitrate Dehydrogenase / genetics. Lectins / metabolism. Mutation / genetics.
Tumor
Suppressor Protein p53 / genetics
[MeSH-minor]
Adipokines. Adolescent. Adult. Brain Neoplasms / genetics. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Child. Child, Preschool. Chitinase-3-Like Protein 1. DNA,
Neoplasm
/ genetics. Female. Humans. Immunoenzyme Techniques. Infant. Infant, Newborn. Male.
Neoplasm
Staging. Polymerase Chain Reaction. Prognosis. Young Adult
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(PMID = 20174854.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Adipokines; 0 / CHI3L1 protein, human; 0 / Chitinase-3-Like Protein 1; 0 / DNA, Neoplasm; 0 / Glycoproteins; 0 / Lectins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42. / IDH1 protein, human
34.
Kirby S, Gertler SZ, Mason W, Watling C, Forsyth P, Aniagolu J, Stagg R, Wright M, Powers J, Eisenhauer EA:
Phase 2 study of T138067-sodium in patients with malignant glioma: Trial of the National Cancer Institute of Canada Clinical Trials Group.
Neuro Oncol
; 2005 Apr;7(2):183-8
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[Title]
Phase 2 study of T138067-sodium in patients with
malignant
glioma: Trial of the National Cancer Institute of Canada Clinical Trials Group.
We studied the activity of T138067-sodium in patients with
malignant
gliomas.
Patients with recurrent
anaplastic astrocytoma
or glioblastoma multiforme were treated intravenously with 330 mg/m(2) of T138067-sodium weekly.
There were two patients with
anaplastic astrocytoma
and 16 with glioblastoma multiforme.
Our results suggest that given in this dose and schedule T138067-sodium does not have activity in this population of
anaplastic astrocytoma
and glioblastoma multiforme.
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(PMID = 15831236.001).
[ISSN]
1522-8517
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
eng
[Publication-type]
Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Sulfonamides; T4NP8G3K6Q / batabulin
[Other-IDs]
NLM/ PMC1871890
35.
McGirt MJ, Mukherjee D, Chaichana KL, Than KD, Weingart JD, Quinones-Hinojosa A:
Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme.
Neurosurgery
; 2009 Sep;65(3):463-9; discussion 469-70
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OBJECTIVE: Balancing the benefits of extensive
tumor
resection with the consequence of potential postoperative deficits remains a challenge in
malignant astrocytoma
surgery.
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(PMID = 19687690.001).
[ISSN]
1524-4040
[Journal-full-title]
Neurosurgery
[ISO-abbreviation]
Neurosurgery
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
36.
Marko NF, Prayson RA, Barnett GH, Weil RJ:
Integrated molecular analysis suggests a three-class model for low-grade gliomas: a proof-of-concept study.
Genomics
; 2010 Jan;95(1):16-24
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[Title]
Integrated molecular analysis suggests a three-class model for low-
grade
gliomas: a proof-of-concept study.
INTRODUCTION: We used an integrated molecular analysis strategy to perform class discovery on a population of low-
grade
gliomas (
astrocytomas
, oligodendrogliomas, and mixed gliomas) to improve our understanding of the molecular relationships among these tumors and to reconcile genotypic relationships with current histologic and molecular strategies for
tumor
classification.
Unsupervised class discovery algorithms identified and validated
tumor
clusters with genotypic similarity, and these data were integrated with chromosomal copy number assays and RT-PCR data to define molecular
tumor
subclasses.
RESULTS: Molecular class discovery suggested a three-class model for low-
grade
gliomas.
One discrete cluster of gliomas identified the pilocytic
astrocytomas
, a second grouped the 1p/19q codeleted oligodendrogliomas, and the mixture of remaining 1p/19q intact gliomas, including
astrocytomas
, oligodendrogliomas, and oligoastrocytomas, formed a third cluster with a discrete pattern of expression.
CONCLUSIONS: Integration of genomic, transcriptomic, and
morphologic
data for class discovery suggests a three-class model for low-
grade
gliomas.
Class I represents tumors with molecular similarity to pilocytic
astrocytomas
, class II tumors are similar to 1p/19q codeleted oligodendrogliomas, and class
III
represents infiltrative low-
grade
gliomas.
This classification is similar to current clinical paradigms for low-
grade
gliomas; our work suggests a molecular basis for such models.
This classification may supplement or may serve as the basis for a molecular pathologic alternative to current grading schemes for low-
grade
gliomas and may highlight potential targets for future biologically based treatments or strategies for future clinical trials.
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(PMID = 19835948.001).
[ISSN]
1089-8646
[Journal-full-title]
Genomics
[ISO-abbreviation]
Genomics
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
63231-63-0 / RNA
37.
Hunter SB, Varma V, Shehata B, Nolen JD, Cohen C, Olson JJ, Ou CY:
Apolipoprotein D expression in primary brain tumors: analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue.
J Histochem Cytochem
; 2005 Aug;53(8):963-9
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Apolipoprotein D (apoD) expression has been shown to correlate both with cell cycle arrest and with prognosis in several types of malignancy, including central nervous system
astrocytomas
and medulloblastomas.
Sixteen poorly infiltrating WHO
grade
I glial neoplasms (i.e., pilocytic
astrocytomas
and gangliogliomas) showed an average 20-fold higher apoD expression level compared with the 20 diffusely infiltrating glial neoplasms (i.e., glioblastoma,
anaplastic astrocytoma
, oligodendrogliomas; p=0.00004).
Analyzed as individual
tumor
groups, poorly infiltrating
grade
I pilocytic
astrocytomas
and gangliogliomas differed significantly from each
tumor type
within the diffusely infiltrating higher-
grade
category (p<0.05 for each comparison) but not from each other (p>0.05).
Conversely, each individual
tumor type
within the diffusely infiltrating category differed significantly from both pilocytic
astrocytomas
and gangliogliomas (p<0.05) but did not vary from other infiltrating tumors (p>0.05).
Ependymomas, non-infiltrating
grade
II neoplasms, expressed levels of apoD similar to or lower than levels expressed by the diffusely infiltrating gliomas.
In addition, apoD expression was 5-fold higher in the slowly proliferating
grade
I glial neoplasms compared with non-proliferating normal brain tissue (p=0.01), suggesting that apoD expression is not simply an inverse measure of proliferation.
ApoD expression measured by quantitative RT-PCR may be useful in the differential diagnosis of primary brain tumors, particularly pilocytic
astrocytomas
and gangliogliomas.
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(PMID = 16055749.001).
[ISSN]
0022-1554
[Journal-full-title]
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
[ISO-abbreviation]
J. Histochem. Cytochem.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Apolipoproteins; 0 / Apolipoproteins D; 0 / Fixatives; 0 / Ki-67 Antigen; 1HG84L3525 / Formaldehyde; 8002-74-2 / Paraffin
38.
Paulino AC, Mai WY, Chintagumpala M, Taher A, Teh BS:
Radiation-induced malignant gliomas: is there a role for reirradiation?
Int J Radiat Oncol Biol Phys
; 2008 Aug 1;71(5):1381-7
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[Title]
Radiation-induced
malignant
gliomas: is there a role for reirradiation?
PURPOSE: To review the literature regarding the role of radiotherapy (RT) in the treatment of patients with radiation-induced
malignant
gliomas (RIMGs).
RESULTS: Initial
tumor
types treated with RT included brain
tumor
in 37 patients (40%), acute lymphoblastic leukemia in 33 (36%), benign disease in 11 (12%), and other in 11 (12%).
Type
of RIMG was glioblastoma in 69 (75%) and
anaplastic astrocytoma
in 23 (25%).
One-, 2-, and 5-year overall survival rates were 29.3%, 7.3%, and 0% for patients with glioblastoma and 59.7%, 30.3%, and 20.2% for patients with
anaplastic astrocytoma
.
[MeSH-minor]
Astrocytoma
/ radiotherapy. Glioblastoma / radiotherapy. Humans. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy. Retreatment. Survival Rate
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[CommentIn]
Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):304-5; author reply 305
[
18722290.001
]
(PMID = 18262733.001).
[ISSN]
0360-3016
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
62
39.
Tanaka S, Akimoto J, Kobayashi I, Oka H, Ujiie H:
Individual adjuvant therapy for malignant gliomas based on O6-methylguanine-DNA methyltransferase messenger RNA quantitation by real-time reverse-transcription polymerase chain-reaction.
Oncol Rep
; 2008 Jul;20(1):165-71
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[Title]
Individual adjuvant therapy for
malignant
gliomas based on O6-methylguanine-DNA methyltransferase messenger RNA quantitation by real-time reverse-transcription polymerase chain-reaction.
A new adjuvant therapy, individual adjuvant therapy (IAT), which is individualized according to the results of real-time reverse-transcription polymerase chain-reaction (RT-PCR) for O6-methylguanine-DNA methyltransferase (MGMT), was used to treat
malignant
gliomas.
Immediately after the operation, mRNA expression for drug-resistance genes was investigated in frozen samples of
malignant
gliomas from 55 patients (30 glioblastoma multiformes, 20
anaplastic
astrocytomas
and 5
anaplastic
oligodendroglial tumors) by real-time quantitative RT-PCR with specific primers for MGMT.
The response rate was 40.9% for glioblastoma multiformes, 60.0% for
anaplastic
astrocytomas
and 80.0% for
anaplastic
oligodendroglial tumors.
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(PMID = 18575733.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
0 / RNA, Messenger; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
40.
Walker DG, Laherty R, Tomlinson FH, Chuah T, Schmidt C:
Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy.
J Clin Neurosci
; 2008 Feb;15(2):114-21
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[Title]
Results of a phase I dendritic cell vaccine trial for
malignant astrocytoma
: potential interaction with adjuvant chemotherapy.
Dendritic cell vaccination has been applied to the treatment of a variety of cancers, including
malignant astrocytoma
.
We have treated 13 patients with
malignant astrocytoma
using dendritic cell vaccination and have shown that this treatment is safe and is likely to be effective in combination with standard adjuvant therapy.
[MeSH-major]
Astrocytoma
/ therapy. Brain Neoplasms / therapy. Cancer Vaccines / therapeutic use. Chemotherapy, Adjuvant / methods. Dendritic Cells / immunology. Immunotherapy, Active / methods
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(PMID = 18083572.001).
[ISSN]
0967-5868
[Journal-full-title]
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
[ISO-abbreviation]
J Clin Neurosci
[Language]
eng
[Publication-type]
Clinical Trial, Phase I; Journal Article
[Publication-country]
Scotland
[Chemical-registry-number]
0 / Antigens, CD8; 0 / Cancer Vaccines; EC 3.1.3.48 / Antigens, CD45
41.
Torii K, Tsuyuguchi N, Kawabe J, Sunada I, Hara M, Shiomi S:
Correlation of amino-acid uptake using methionine PET and histological classifications in various gliomas.
Ann Nucl Med
; 2005 Dec;19(8):677-83
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OBJECTIVE: The uptake of L-methyl-11C-methionine (MET) by gliomas is greater than that by intact tissue, making methionine very useful for evaluation of
tumor
extent.
Tumors included diffuse
astrocytoma
,
anaplastic astrocytoma
, glioblastoma, ependymoma, oligodendroglioma, medulloblastoma, dysembryoplastic neuroepithelial
tumor
, choroid plexus papilloma, central neurocytoma, optic glioma, gliomatosis cerebri, pleomorphic xanthoastrocytoma, and ganglioglioma.
Tumor
activity and degree of malignancy were evaluated using Ki-67LI (LI: labeling index) and Kaplan-Meier survival curves.
The correlations between methionine uptake and
tumor
proliferation (
tumor
versus contralateral gray matter ratio (T/N) and Ki-67LI) were determined for the group of all subjects.
The existence of significant correlations between T/N and Ki-67LI and between SUV and Ki-67LI was determined for
astrocytic
tumors.
Receiver operating characteristics (ROC) analysis of T/N and standardized uptake value (SUV) was performed for the group of
astrocytic
tumors.
Ki-67LI differed significantly between the high-
grade
group and low-
grade
group at T/N levels between 1.5 and 1.8 on analysis using
tumor
proliferative potential (p = 0.019-0.031).
The prognosis differed significantly between the high-
grade
and low-
grade
groups when T/N was in the range of 1.6-1.8 (p = 0.028-0.032).
CONCLUSIONS: When analysis was confined to cases of
astrocytic tumor
, a correlation was noted between methionine accumulation and Ki-67LI.
For the
astrocytic
tumors, T/N ratio seemed to be more useful as a diagnostic indicator than SUV.
The cut-off level of T/N ratio for distinction between high-
grade
and low-
grade
astrocytoma
appears to lie between 1.5 and 1.6.
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(PMID = 16444993.001).
[ISSN]
0914-7187
[Journal-full-title]
Annals of nuclear medicine
[ISO-abbreviation]
Ann Nucl Med
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Radiopharmaceuticals; 58576-49-1 / carbon-11 methionine; AE28F7PNPL / Methionine
42.
Sadones J, Michotte A, Veld P, Chaskis C, Sciot R, Menten J, Joossens EJ, Strauven T, D'Hondt LA, Sartenaer D, Califice SF, Bierau K, Svensson C, De Grève J, Neyns B:
MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.
Eur J Cancer
; 2009 Jan;45(1):146-53
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[Title]
MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent
anaplastic astrocytoma
but not glioblastoma.
AIMS: To investigate the correlation between O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and benefit from temozolomide in patients with recurrent high-
grade
glioma.
RESULTS: A subgroup of 38 patients who were chemotherapy-naive at recurrence was analysed (22 glioblastoma, 12
anaplastic astrocytoma
[AA] and 4
anaplastic
oligoastrocytoma [AOA]); none had 1p/19q loss.
By Cox multivariate analysis, tumour
grade
and MGMT promoter methylation correlated with time to progression (p<0.05); MGMT promoter methylation correlated with superior overall survival in AA/AOA but not in glioblastoma.
[MeSH-major]
Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ drug therapy. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. O(6)-Methylguanine-DNA Methyltransferase / genetics. Promoter Regions, Genetic
[MeSH-minor]
Adult. Aged. Aged, 80 and over. DNA Methylation. Female. Glioblastoma / drug therapy. Humans. Kaplan-Meier Estimate. Male. Middle Aged.
Neoplasm
Recurrence, Local / drug therapy.
Neoplasm
Recurrence, Local / mortality. Prognosis. Retrospective Studies. Survival Rate. Young Adult
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(PMID = 18945611.001).
[ISSN]
1879-0852
[Journal-full-title]
European journal of cancer (Oxford, England : 1990)
[ISO-abbreviation]
Eur. J. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
43.
Stettner MR, Wang W, Nabors LB, Bharara S, Flynn DC, Grammer JR, Gillespie GY, Gladson CL:
Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells.
Cancer Res
; 2005 Jul 1;65(13):5535-43
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[Title]
Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma
tumor
cells.
As we have found that Lyn, but not Fyn, activity promotes migration of glioblastoma cells in response to the cooperative signal generated by platelet-derived growth factor receptor beta and integrin alpha(v)beta3, we compared the activity and expression of Lyn and Fyn in glioblastoma (
grade
IV)
tumor
biopsy samples with that in
anaplastic astrocytoma
(
grade III
) tumors, nonneoplastic brain, and normal autopsy brain samples.
Lyn kinase activity was significantly elevated in glioblastoma
tumor
samples.
The levels of phosphorylation of the autophosphorylation site were consistent with significantly higher Lyn activity in glioblastoma
tumor
tissue than nonneoplastic brain.
Immunostaining revealed that Lyn is located primarily in the glioblastoma cells in the
tumor
biopsies.
These data indicate that Lyn kinase activity is significantly elevated in glioblastoma tumors and suggest that it is the Lyn activity that promotes the
malignant
phenotype in these tumors.
[MeSH-minor]
Astrocytoma
/ enzymology.
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Biopsy. Brain / enzymology. Endothelial Cells / enzymology. Humans. Immunohistochemistry. Phosphotransferases / genetics. Phosphotransferases / metabolism. Protein-Tyrosine Kinases. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-fyn. RNA, Messenger / genetics. RNA, Messenger / metabolism
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(PMID = 15994925.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA97110; United States / NCI NIH HHS / CA / P50 CA97247
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; EC 2.7.- / Phosphotransferases; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / CSK tyrosine-protein kinase; EC 2.7.10.2 / FYN protein, human; EC 2.7.10.2 / Proto-Oncogene Proteins c-fyn; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases
44.
Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M:
Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene.
Clin Cancer Res
; 2005 Feb 1;11(3):1119-28
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[Title]
Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate
tumor
suppressor gene.
PURPOSE: Allelic loss at 1p is seen in 70% to 85% of oligodendrogliomas (typically in association with 19q allelic loss) and 20-30% of
astrocytomas
.
Because most 1p deletions in gliomas involve almost the entire chromosome arm, narrowing the region of the putative
tumor
suppressor gene has been difficult.
The latter group included both low-
grade
tumors (oligodendroglioma, diffuse
astrocytoma
, and "oligoastrocytoma") and high-
grade
tumors (
anaplastic
oligodendrogliomas,
anaplastic
astrocytomas
,
anaplastic
oligoastrocytomas).
RESULTS: Allelic losses on 1p and 19q, either separately or combined, were more common in classic oligodendrogliomas than in either
astrocytomas
or oligoastrocytomas (P < 0.0001).
There was no significant difference in 1p/19q LOH status between low-
grade
and
anaplastic
oligodendrogliomas.
In contrast, no
astrocytomas
and only 6 of 30 (20%) oligoastrocytic tumors had combined 1p/19q loss.
Although rare, 1p deletions were more often segmental in
astrocytomas
(5 of 6, 83%) than in oligodendrogliomas (3 of 35, 9%; P = 0.006).
Eleven tumors (6 oligodendrogliomas or having oligodendroglial components, 5 purely
astrocytic
) with small segmental 1p losses underwent further detailed LOH mapping.
All informative tumors in the oligodendroglial group and 2 of 3 informative
astrocytomas
showed LOH at 1p36.23, with a 150-kb MDR located between D1S2694 and D1S2666, entirely within the CAMTA1 transcription factor gene.
[MeSH-minor]
Adult.
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Calcium-Binding Proteins / genetics. Chromosome Deletion. Chromosome Mapping. Expressed Sequence Tags. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Genes,
Tumor
Suppressor. Humans. Microsatellite Repeats. Mutation. Oligodendroglioma / genetics. Oligodendroglioma / pathology. Reverse Transcriptase Polymerase Chain Reaction. Trans-Activators / genetics
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(PMID = 15709179.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / CAMTA1 protein, human; 0 / Calcium-Binding Proteins; 0 / Trans-Activators
45.
Nano R, Capelli E, Facoetti A, Benericetti E:
Immunobiological and experimental aspects of malignant astrocytoma.
Anticancer Res
; 2009 Jul;29(7):2461-5
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[Title]
Immunobiological and experimental aspects of
malignant astrocytoma
.
Starting from 1992, the goal of our studies was to obtain new biological data on
malignant
astrocytomas
to better understand the basic biology of the tumour and these are reviewed here.
[MeSH-major]
Astrocytoma
/ immunology. Brain Neoplasms / immunology
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(PMID = 19596914.001).
[ISSN]
1791-7530
[Journal-full-title]
Anticancer research
[ISO-abbreviation]
Anticancer Res.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Greece
[Chemical-registry-number]
0 / Interleukin-2
[Number-of-references]
51
46.
Jeannin S, Lebrun C, Van Den Bos F, Olschwang S, Bourg V, Frenay M:
[Turcot's syndrome confirmed by molecular biological tests].
Rev Neurol (Paris)
; 2006 Jun;162(6-7):741-6
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[Transliterated title]
Syndrome
de
Turcot confirmé par biologie moléculaire.
INTRODUCTION: Turcot's syndrome is characterized clinically by the concurrence of a primary brain
tumor
and a familial adenomatous polyposis or a hereditary nonpolyposis colorectal cancer.
OBSERVATION: We report a case of a 45-year-old woman who underwent in 1995 neuro-oncological treatment for an
anaplastic astrocytoma
(
grade III
according to the World Health Organization classification).
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(PMID = 16840983.001).
[ISSN]
0035-3787
[Journal-full-title]
Revue neurologique
[ISO-abbreviation]
Rev. Neurol. (Paris)
[Language]
fre
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
France
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
47.
Chamberlain MC, Johnston S:
Salvage chemotherapy with bevacizumab for recurrent alkylator-refractory anaplastic astrocytoma.
J Neurooncol
; 2009 Feb;91(3):359-67
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[Title]
Salvage chemotherapy with bevacizumab for recurrent alkylator-refractory
anaplastic astrocytoma
.
A retrospective study of bevacizumab only in adults with recurrent temozolomide (TMZ)-refractory
anaplastic astrocytoma
(AA) with a primary objective of determining progression free survival (PFS).
Bevacizumab-related toxicity included fatigue (14 patients; 2
grade
3), leukopenia (7; 1
grade
3), deep vein thrombosis (5; 2
grade
3), hypertension (5; 1
grade
3), anemia (4; 0
grade
3) and wound dehiscence (1; 1
grade
3).
Time to
tumor
progression ranged from 1 to 20 months (median: 7).
[MeSH-major]
Angiogenesis Inhibitors / therapeutic use. Antibodies, Monoclonal / therapeutic use.
Astrocytoma
/ drug therapy.
Astrocytoma
/ mortality. Brain Neoplasms / drug therapy. Brain Neoplasms / mortality.
Neoplasm
Recurrence, Local
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J Clin Oncol. 2007 Oct 20;25(30):4714-21
[
17947718.001
]
(PMID = 18953491.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab
48.
Znidaric MT, Pucer A, Fatur T, Filipic M, Scancar J, Falnoga I:
Metal binding of metallothioneins in human astrocytomas (U87 MG, IPDDC-2A).
Biometals
; 2007 Oct;20(5):781-92
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[Title]
Metal binding of metallothioneins in human
astrocytomas
(U87 MG, IPDDC-2A).
For this reason astroglia cells possess high cytosolic levels of metallothioneins I, II and
III
(MT-I,II,
III
).
Our aim was to establish the inducibility and metal binding of MTs in two human
astrocytoma
cell lines, U87 MG (
astrocytoma
-glioblastoma,
grade
IV) and IPDDC-2A (
astrocytoma
,
grade
II), on exposure to cadmium chloride (1 microM).
We showed that MTs are constitutively expressed in both human
astrocytoma
cell lines.
In accordance with the higher malignancy
grade
of U87 MG, the amount of MTs was higher in U87 MG than in IPDDC-2A cells.
Isoform
III
(identified by chromatographic separation of isoform
III
from I/II) was present at all exposure times, but only in traces with respect to the prevailing amounts of MT-I/II isoforms.
[MeSH-major]
Astrocytoma
/ metabolism. Metallothionein / metabolism. Metals / metabolism
[MeSH-minor]
Cadmium Chloride / metabolism. Cadmium Chloride / pharmacology. Cadmium Chloride / toxicity. Cell Line,
Tumor
. Cell Survival / drug effects. Dose-Response Relationship, Drug. Humans. Protein Binding / physiology
Hazardous Substances Data Bank.
CADMIUM CHLORIDE
.
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(PMID = 17115260.001).
[ISSN]
0966-0844
[Journal-full-title]
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
[ISO-abbreviation]
Biometals
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Metals; 9038-94-2 / Metallothionein; J6K4F9V3BA / Cadmium Chloride
49.
Da Fonseca CO, Silva JT, Lins IR, Simão M, Arnobio A, Futuro D, Quirico-Santos T:
Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol.
Invest New Drugs
; 2009 Dec;27(6):557-64
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[Title]
Correlation of
tumor
topography and peritumoral edema of recurrent
malignant
gliomas with therapeutic response to intranasal administration of perillyl alcohol.
BACKGROUND: The aim of this study was to establish a correlation of
tumor
topography and peritumoral brain edema with the therapeutic response to intranasal administration of perillyl alcohol (POH) in a cohort of patients with recurrent
malignant
gliomas.
METHODS: The retrospective study reviewed clinical and neuroradiological data from patients with recurrent
malignant
gliomas who received intranasal daily administration of POH 440 mg.
The following parameters were assessed: demographic characteristics, initial symptoms, overall survival,
tumor
topography and
tumor
size, presence of midline shift and extent of peritumoral edema.
RESULTS: A cohort of 67 patients included 52 (78%) with glioblastoma (GBM), ten (15%) with
anaplastic astrocytoma
(AA) and five (7%) with
anaplastic
oligodendroglioma (AO).
Accordingly to
tumor
topography lobar localization was present in all (5/5) AO; eight (8/10) and 41 GBM patients whereas in the basal ganglia two AA and 11 GBM patients.
It was also observed a relation between the
tumor
size and area of peritumoral brain edema (PTBE).
Patients with good therapeutic response showed reduction of
tumor
size and PTBE area, but poor prognosis was associated with lack of response to treatment and persistence of high PTBE.
Patients with
tumor
in the basal ganglia survived significantly longer than those with lobar gliomas (log rank test, p = 0.0003).
(2) presence of PTBE contributes to symptoms, likely to be implicated in the morbidity and invading potential of
malignant
gliomas.
[MeSH-major]
Antineoplastic Agents / therapeutic use. Brain Edema / pathology. Brain Neoplasms / drug therapy. Glioma / drug therapy. Glioma / pathology. Monoterpenes / therapeutic use.
Neoplasm
Recurrence, Local / pathology
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[Cites]
Lancet Neurol. 2005 Jul;4(7):413-22
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(PMID = 19139816.001).
[ISSN]
1573-0646
[Journal-full-title]
Investigational new drugs
[ISO-abbreviation]
Invest New Drugs
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Monoterpenes; 319R5C7293 / perillyl alcohol
50.
Shukla B, Agarwal S, Suri V, Pathak P, Sharma MC, Gupta D, Sharma BS, Suri A, Halder A, Sarkar C:
Assessment of 1p/19q status by fluorescence in situ hybridization assay: A comparative study in oligodendroglial, mixed oligoastrocytic and astrocytic tumors.
Neurol India
; 2009 Sep-Oct;57(5):559-66
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[Title]
Assessment of 1p/19q status by fluorescence in situ hybridization assay: A comparative study in oligodendroglial, mixed oligoastrocytic and
astrocytic
tumors.
Astrocytomas
and the
astrocytic
component of oligoastrocytomas showed a diffuse fibrillary
type
of staining.
None of the
astrocytomas
including two pediatric cases showed this alteration (P < 0.05).
p53 was expressed in 57.1% of
astrocytomas
(8/14), 33% of mixed oligoastrocytomas (3/9) and 10% of oligodendrogliomas (2/20).
In contrast, all
astrocytomas
(
Grade
II and
III
) were EGFR negative.
CONCLUSION: Loss of 1p/19q is strongly associated with oligodendroglial phenotype, while
astrocytic
tumors are more likely to show p53 over-expression. p53 expression and 1p/19q status appear to be mutually exclusive.
[MeSH-major]
Astrocytoma
/ genetics. Brain Neoplasms / genetics. Chromosomes, Human, Pair 19. In Situ Hybridization, Fluorescence / methods. Oligodendroglioma / genetics
[MeSH-minor]
Adolescent. Adult. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Male. Middle Aged. Receptor, Epidermal Growth Factor / metabolism. Retrospective Studies.
Tumor
Suppressor Protein p53 / metabolism. Young Adult
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(PMID = 19934553.001).
[ISSN]
0028-3886
[Journal-full-title]
Neurology India
[ISO-abbreviation]
Neurol India
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
India
[Chemical-registry-number]
0 / Glial Fibrillary Acidic Protein; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
51.
Raza SM, Garzon-Muvdi T, Boaehene K, Olivi A, Gallia G, Lim M, Subramanian P, Quinones-Hinojosa A:
The supraorbital craniotomy for access to the skull base and intraaxial lesions: a technique in evolution.
Minim Invasive Neurosurg
; 2010 Feb;53(1):1-8
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Intra-axial pathology ranged from
anaplastic astrocytoma
to metastasis while extra-axial lesions included meningiomas and skull-based metastases.
[MeSH-minor]
Adenoma / surgery.
Astrocytoma
/ surgery. Breast Neoplasms / surgery. Craniopharyngioma / surgery. Esthetics. Eyebrows. Eyelids. Female. Follow-Up Studies. Frontal Lobe / surgery. Humans. Male. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Pituitary Neoplasms / surgery. Postoperative Complications / etiology. Treatment Outcome
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[Copyright]
(c) Georg Thieme Verlag KG Stuttgart . New York.
(PMID = 20376737.001).
[ISSN]
1439-2291
[Journal-full-title]
Minimally invasive neurosurgery : MIN
[ISO-abbreviation]
Minim Invasive Neurosurg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
52.
Kim JH, Choi C, Benveniste EN, Kwon D:
TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells.
Biochem Biophys Res Commun
; 2008 Dec 5;377(1):195-9
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[Title]
TRAIL induces MMP-9 expression via ERK activation in human
astrocytoma
cells.
Matrix metalloproteinase-9 (MMP-9) is an important angiogenic and prognostic factor in
malignant
tumors.
Tumor
necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known as the death ligand, which induces preferential apoptosis of transformed
tumor
cells.
We demonstrated that TRAIL induces MMP-9 expression in human
astrocytoma
cells, which is preceded by activation of extracellular signal-regulated protein kinase (ERK).
These findings indicate that TRAIL treatment in human
astrocytoma
cells leads to the activation of NF-kappaB and subsequent expression of MMP-9, which are dependent on ERK activation.
Collectively, these results suggest that TRAIL has alternative biological functions in addition to its role in inducing apoptosis in human
malignant astrocytoma
cells.
[MeSH-major]
Astrocytoma
/ enzymology. Extracellular Signal-Regulated MAP Kinases / metabolism. Matrix Metalloproteinase 9 / biosynthesis. TNF-Related Apoptosis-Inducing Ligand / physiology
[MeSH-minor]
Butadienes / pharmacology. Cell Line,
Tumor
. Enzyme Activation. Humans. NF-kappa B / metabolism. Nitriles / pharmacology. Protein Kinase Inhibitors
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(PMID = 18834856.001).
[ISSN]
1090-2104
[Journal-full-title]
Biochemical and biophysical research communications
[ISO-abbreviation]
Biochem. Biophys. Res. Commun.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Butadienes; 0 / NF-kappa B; 0 / Nitriles; 0 / Protein Kinase Inhibitors; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / U 0126; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.4.24.35 / Matrix Metalloproteinase 9
53.
Tanaka S, Kobayashi I, Utsuki S, Iwamoto K, Takanashi J:
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report.
Neurol Med Chir (Tokyo)
; 2005 Jan;45(1):49-55
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Partial resection of the
tumor
was safely performed, with slight temporary neurological worsening.
The histological diagnosis was
anaplastic astrocytoma
.
Individual adjuvant therapy based on the results of real-time reverse transcription-polymerase chain reaction of O6-methylguanine-deoxyribonucleic acid methyltransferase achieved an almost complete
tumor
response.
[MeSH-major]
Astrocytoma
/ surgery. Brain Mapping. Brain Stem Neoplasms / surgery. Evoked Potentials, Motor. Mesencephalon / physiopathology. Neurosurgical Procedures / methods
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(PMID = 15699622.001).
[ISSN]
0470-8105
[Journal-full-title]
Neurologia medico-chirurgica
[ISO-abbreviation]
Neurol. Med. Chir. (Tokyo)
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
54.
Compostella A, Tosoni A, Blatt V, Franceschi E, Brandes AA:
Prognostic factors for anaplastic astrocytomas.
J Neurooncol
; 2007 Feb;81(3):295-303
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[Title]
Prognostic factors for
anaplastic
astrocytomas
.
Anaplastic
astrocytomas
(WHO
grade III
) constitute about 10% of all gliomas.
Definitive data on predictive and prognostic factors are lacking for these neoplasms that are considered the most enigmatic entity among the whole spectrum of
astrocytic
tumors because of their unclear biologic behavior and variable clinical outcome.
Currently, only few factors have been identified as useful for prognosis of
anaplastic astrocytoma
: age and Karnofsky Performance Status.
Potential prognostic biomarkers concern
tumor
suppressor genes on chromosome 9q that are involved in the RB1 pathway; PTEN, the PI3k/Akt/p70s6k cascade, survivin gene, Formylpeptide receptor, minichromosome maintenance protein 3 and genes on chromosome 7.
The state of the art pictured here underlie the recent interest on gene expression profile to identify aberrations useful to understand the biologic behavior of
astrocytic
tumors.
[MeSH-major]
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Biomarkers,
Tumor
/ analysis. Brain Neoplasms / genetics. Brain Neoplasms / pathology
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0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Number-of-references]
55
55.
Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S:
FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells.
Cancer Res
; 2008 Nov 1;68(21):8733-42
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We previously found that FoxM1B is overexpressed in human glioblastomas and that forced FoxM1B expression in
anaplastic astrocytoma
cells leads to the formation of highly angiogenic glioblastoma in nude mice.
Our findings provide both clinical and mechanistic evidence that FoxM1 contributes to glioma progression by enhancing VEGF gene transcription and thus
tumor
angiogenesis.
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]
(PMID = 18974115.001).
[ISSN]
1538-7445
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA-16672; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / R01 CA116528-03; United States / NCI NIH HHS / CA / CA116528-03; United States / NCI NIH HHS / CA / R01-CA-116528; United States / NCI NIH HHS / CA / R01 CA116528; United States / NCI NIH HHS / CA / R01 CA116528-02; United States / NCI NIH HHS / CA / CA116528-02
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA Primers; 0 / FOXM1 protein, human; 0 / Forkhead Transcription Factors; 0 / Vascular Endothelial Growth Factor A
[Other-IDs]
NLM/ NIHMS67455; NLM/ PMC2597644
56.
Vlodavsky E, Soustiel JF:
Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival.
J Neurooncol
; 2007 Jan;81(1):1-7
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[Title]
Immunohistochemical expression of peripheral benzodiazepine receptors in human
astrocytomas
and its correlation with
grade
of malignancy, proliferation, apoptosis and survival.
It has been established that the expression of PBR in
astrocytomas
is higher than in the normal brain.
The goal of this study was to explore the correlation of the immunohistochemical expression of PBR in
astrocytomas
with the
grade
of malignancy and rates of apoptosis, proliferation and survival.
In 130 cases of
astrocytomas
(25
grade
I, 25
grade
II, 20
grade III
, 60
grade
IV), paraffin sections were stained immunohistochemically for PBR and MIB-1(Ki-67).
It was found that the intensity and extent of staining for PBR had a strong direct correlation with the
grade
of malignancy of the
tumor
, along with proliferative and apoptotic indices.
The highest expression of PBR was in glioblastomas
grade
IV, especially around areas of necrosis.
The results of this study may be applied in the pathological diagnosis of
astrocytomas
as an additional clue in establishing
tumor
grade
; they may be used in the imaging of
astrocytomas
, both for diagnosis and follow-up, by the application of positron emission tomography scanning with PBR specific ligands.
Targeting of PBR in high-
grade
gliomas may be a promising approach, achieving more specific anti-
tumor
effect.
[MeSH-major]
Apoptosis / physiology.
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Glioblastoma / metabolism. Receptors, GABA / metabolism
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J Pathol. 2001 Mar;193(3):377-82
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11241419.001
]
(PMID = 16868661.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Ki-67 Antigen; 0 / Receptors, GABA; 0 / TSPO protein, human
57.
Waha A, Felsberg J, Hartmann W, von dem Knesebeck A, Mikeska T, Joos S, Wolter M, Koch A, Yan PS, Endl E, Wiestler OD, Reifenberger G, Pietsch T, Waha A:
Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells.
Cancer Res
; 2010 Feb 15;70(4):1689-99
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Critical
tumor
suppression pathways in brain tumors have yet to be fully defined.
In 83
astrocytic
gliomas and 5 glioma cell lines examined, hypermethylation of the MKP-2 promoter was found to occur relatively more frequently in diffuse or
anaplastic
astrocytomas
and secondary glioblastomas relative to primary glioblastomas.
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Cell Line,
Tumor
. DNA Methylation. Down-Regulation / physiology. Female. Gene Expression Regulation, Neoplastic / physiology. Gene Silencing / physiology. Genes,
Tumor
Suppressor / physiology. Humans. Male. Middle Aged
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(PMID = 20124482.001).
[ISSN]
1538-7445
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
EC 3.1.3.- / Mitogen-Activated Protein Kinase Phosphatases; EC 3.1.3.48 / DUSP4 protein, human; EC 3.1.3.48 / Dual-Specificity Phosphatases
58.
Kinjo S, Hirato J, Nakazato Y:
Low grade diffuse gliomas: shared cellular composition and morphometric differences.
Neuropathology
; 2008 Oct;28(5):455-65
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[Title]
Low
grade
diffuse gliomas: shared cellular composition and morphometric differences.
Low
grade
diffuse gliomas arising in the brain are challenging to treat because of their ability to infiltrate adjacent tissue.
We attempted to clarify the cellular composition and histopathological features of low
grade
gliomas by utilizing morphometric and immunohistochemical analyses.
Seventy-eight cases of low
grade
gliomas were examined including 21 diffuse
astrocytomas
(DA), 36 oligodendrogliomas (OL), and 21 oligoastrocytomas (OA), based on the WHO classification system.
Moreover, OL were subdivided into three types based on the morphological characteristics advocated by Daumas-Duport et al.: OL
type
I, OL
type
II, and OL
type
III
.
Morphometric data indicated that the cellularity of OL
type
II was significantly higher than that of DA, and that the conditional entropy of OL
type
III
was significantly lower than that of DA.
We conclude that each glioma include cells expressing GFAP, cells expressing nestin, and cells expressing Olig2 in a characteristic proportion for each
tumor type
.
[MeSH-minor]
Basic Helix-Loop-Helix Transcription Factors / biosynthesis. Fluorescent Antibody Technique. Glial Fibrillary Acidic Protein / biosynthesis. Humans. Image Interpretation, Computer-Assisted. Immunohistochemistry. Intermediate Filament Proteins / biosynthesis. Nerve Tissue Proteins / biosynthesis. Nestin.
Tumor
Suppressor Protein p53 / biosynthesis
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(PMID = 18282166.001).
[ISSN]
1440-1789
[Journal-full-title]
Neuropathology : official journal of the Japanese Society of Neuropathology
[ISO-abbreviation]
Neuropathology
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Australia
[Chemical-registry-number]
0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / OLIG2 protein, human; 0 / Tumor Suppressor Protein p53
59.
Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A, Felsberg J, Wolter M, Mawrin C, Wick W, Weller M, Herold-Mende C, Unterberg A, Jeuken JW, Wesseling P, Reifenberger G, von Deimling A:
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.
Acta Neuropathol
; 2009 Oct;118(4):469-74
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[Title]
Type
and frequency of IDH1 and IDH2 mutations are related to
astrocytic
and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.
Somatic mutations in the IDH1 gene encoding cytosolic NADP+-dependent isocitrate dehydrogenase have been shown in the majority of
astrocytomas
, oligodendrogliomas and oligoastrocytomas of WHO grades II and
III
.
Preliminary data suggest an importance of IDH1 mutation for prognosis showing that patients with
anaplastic
astrocytomas
, oligodendrogliomas and oligoastrocytomas harboring IDH1 mutations seem to fare much better than patients without this mutation in their tumors.
We found 165 IDH1 (72.7%) and 2 IDH2 mutations (0.9%) in 227 diffuse
astrocytomas
WHO
grade
II, 146 IDH1 (64.0%) and 2 IDH2 mutations (0.9%) in 228
anaplastic
astrocytomas
WHO
grade III
, 105 IDH1 (82.0%) and 6 IDH2 mutations (4.7%) in 128 oligodendrogliomas WHO
grade
II, 121 IDH1 (69.5%) and 9 IDH2 mutations (5.2%) in 174
anaplastic
oligodendrogliomas WHO
grade III
, 62 IDH1 (81.6%) and 1 IDH2 mutations (1.3%) in 76 oligoastrocytomas WHO
grade
II and 117 IDH1 (66.1%) and 11 IDH2 mutations (6.2%) in 177
anaplastic
oligoastrocytomas WHO
grade III
.
We report on an inverse association of IDH1 and IDH2 mutations in these gliomas and a non-random distribution of the mutation types within the
tumor
entities.
IDH1 mutations of the R132C
type
are strongly associated with
astrocytoma
, while IDH2 mutations predominantly occur in oligodendroglial tumors.
In addition, patients with
anaplastic
glioma harboring IDH1 mutations were on average 6 years younger than those without these alterations.
[MeSH-minor]
Adult. Age Factors. Brain / pathology. Cell Differentiation. DNA Mutational Analysis. Female. Humans. Male. Middle Aged. Mutation. Prognosis.
Tumor
Cells, Cultured
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(PMID = 19554337.001).
[ISSN]
1432-0533
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
EC 1.1.1.41 / Isocitrate Dehydrogenase
60.
Raco A, Piccirilli M, Landi A, Lenzi J, Delfini R, Cantore G:
High-grade intramedullary astrocytomas: 30 years' experience at the Neurosurgery Department of the University of Rome "Sapienza".
J Neurosurg Spine
; 2010 Feb;12(2):144-53
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[Title]
High-
grade
intramedullary
astrocytomas
: 30 years' experience at the Neurosurgery Department of the University of Rome "Sapienza".
OBJECT: The goal in this study was to review a series of patients who underwent surgical removal of intramedullary high-
grade
gliomas, focusing on the functional outcome, recurrence rates, and technical problems continually debated in neurosurgical practice.
METHODS: Between December 1976 and December 2006, 22 patients underwent removal of intramedullary high-
grade
gliomas.
RESULTS: Histological examinations showed 10
Grade III astrocytomas
and 12 glioblastomas.
Only 2 of the 22 high-
grade astrocytomas
could be completely removed.
In this series, multimodality treatment of intramedullary high-
grade astrocytomas
has been shown to increase length of survival without improving the neurological status.
[MeSH-major]
Astrocytoma
/ surgery. Spinal Cord Neoplasms / surgery
[MeSH-minor]
Adolescent. Adult. Cervical Vertebrae. Child. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged.
Neoplasm
Recurrence, Local. Neurosurgical Procedures / methods. Neurosurgical Procedures / mortality. Rome. Spinal Cord / pathology. Spinal Cord / surgery. Thoracic Vertebrae. Time Factors. Treatment Outcome. Young Adult
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[CommentIn]
J Neurosurg Spine. 2010 Feb;12(2):141-2; discussion 142-3
[
20121347.001
]
(PMID = 20121348.001).
[ISSN]
1547-5646
[Journal-full-title]
Journal of neurosurgery. Spine
[ISO-abbreviation]
J Neurosurg Spine
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
61.
Pavlisa G, Rados M, Pavlisa G, Pavic L, Potocki K, Mayer D:
The differences of water diffusion between brain tissue infiltrated by tumor and peritumoral vasogenic edema.
Clin Imaging
; 2009 Mar-Apr;33(2):96-101
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[Title]
The differences of water diffusion between brain tissue infiltrated by
tumor
and peritumoral vasogenic edema.
The differences between peritumoral brain tissue infiltrated by
tumor
and vasogenic edema were prospectively evaluated by comparing the apparent diffusion coefficient (ADC) of peritumoral areas of infiltrative tumors (
anaplastic
astrocytomas
and glioblastomas) to that of peritumoral areas of noninfiltrative tumors (metastatic carcinomas) on 54 patients.
Peritumoral ADCs indicated the possibility of differentiation between
tumor
infiltration and vasogenic edema, as well as between primary gliomas and metastases.
[MeSH-minor]
Astrocytoma
/ diagnosis.
Astrocytoma
/ pathology. Female. Glioblastoma / diagnosis. Glioblastoma / pathology. Humans. Male. Middle Aged
Genetic Alliance.
consumer health - Edema
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
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(PMID = 19237051.001).
[ISSN]
1873-4499
[Journal-full-title]
Clinical imaging
[ISO-abbreviation]
Clin Imaging
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
62.
Omar AI, Mason WP:
Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas.
Core Evid
; 2010 Jun 15;4:93-111
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[Title]
Temozolomide: The evidence for its therapeutic efficacy in
malignant
astrocytomas
.
INTRODUCTION:
Malignant
gliomas are a heterogeneous group of primary central nervous system neoplasms that represent less than 2% of all cancers yet carry a significant burden to society.
Temozolomide (TMZ) is a new second generation DNA alkylating agent that has become part of
malignant astrocytoma
management paradigms because of its proven efficacy, ease of administration, and favorable toxicity profile.
AIMS: To review the role of TMZ in the management of
malignant
astrocytomas
(World Health Organization grades
III
and IV) including newly diagnosed (n) and recurrent (r)
anaplastic
astrocytomas
(AA) and glioblastomas.
EVIDENCE REVIEW: A series of pivotal clinical trials have established a role for TMZ in the treatment of
malignant
astrocytomas
.
A recent large prospective randomized phase
III
trial showed that the addition of TMZ during and after radiation therapy (RT) in newly diagnosed (nGBM) patients prolonged median overall survival by 2.5 months; perhaps more importantly, the 2-year survival rate for patients receiving TMZ and RT was 26% compared with 10% for those receiving RT alone.
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(PMID = 20694068.001).
[ISSN]
1555-175X
[Journal-full-title]
Core evidence
[ISO-abbreviation]
Core Evid
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
New Zealand
[Other-IDs]
NLM/ PMC2899776
[Keywords]
NOTNLM ; anaplastic astrocytoma / evidence / glioblastoma / glioma / malignant astrocytoma / temozolomide
63.
Murakami H, Sawa H, Kamada H:
[Expression of cyclooxygenase (COX)-2 in astrocytic tumors and anti-tumor effects of selective COX-2 inhibitors].
No To Shinkei
; 2006 Jan;58(1):43-9
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[Title]
[Expression of cyclooxygenase (COX)-2 in
astrocytic
tumors and anti-
tumor
effects of selective COX-2 inhibitors].
Cyclooxygenase (COX)-2 of
astrocytic
tumors was studied by immunohistochemistry.
COX-2 was expressed in 8 of 12 (75%) glioblastoma multiforme, 1 of 7 (14%)
anaplastic astrocytoma
, but none in
astrocytoma
.
The result showed that COX-2 expression may be related with histological grades and COX-2 inhibitors will be one of promising therapeutic tools in human
astrocytic
tumors.
[MeSH-major]
Astrocytoma
/ enzymology. Cyclooxygenase 2 / analysis. Cyclooxygenase 2 Inhibitors / therapeutic use
[MeSH-minor]
Adult. Aged. Etodolac / pharmacology. Female. Glioblastoma / drug therapy. Glioblastoma / enzymology. Humans. Immunoblotting. Immunohistochemistry. Male. Middle Aged. Nitrobenzenes / pharmacology. Sulfonamides / pharmacology.
Tumor
Cells, Cultured
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(PMID = 16482921.001).
[ISSN]
0006-8969
[Journal-full-title]
Nō to shinkei = Brain and nerve
[ISO-abbreviation]
No To Shinkei
[Language]
jpn
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Cyclooxygenase 2 Inhibitors; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; 2M36281008 / Etodolac; EC 1.14.99.1 / Cyclooxygenase 2
64.
Jang FF, Wei W, De WM:
Vascular endothelial growth factor and basic fibroblast growth factor expression positively correlates with angiogenesis and peritumoural brain oedema in astrocytoma.
J Ayub Med Coll Abbottabad
; 2008 Apr-Jun;20(2):105-9
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[Title]
Vascular endothelial growth factor and basic fibroblast growth factor expression positively correlates with angiogenesis and peritumoural brain oedema in
astrocytoma
.
BACKGROUND:
Astrocytoma
is the most
malignant
intracranial
neoplasm
and is characterized by high neovascularization and peritumoural brain oedema.
METHODS: The expression of two angiogenic growth factors, vascular endothelial growth factor and basic fibroblast growth factor were investigated using immunohistochemistry for
astrocytoma
from 82 patients and 11 normal human tissues.
RESULTS: The expression of vascular endothelial growth factor and basic fibroblast growth factor positively correlate with the pathological
grade
of
astrocytoma
, microvessel density numbers and brain oedema, which may be responsible for the increased tumour neovascularization and peritumoural brain oedema.
CONCLUSION: The results support the idea that inhibiting vascular endothelial growth factor and basic fibroblast growth factor are useful for the treatment of human
astrocytoma
and to improve patient's clinical outcomes and prognosis.
[MeSH-major]
Astrocytoma
/ blood supply. Brain Edema / etiology. Brain Neoplasms / blood supply. Fibroblast Growth Factor 2 / biosynthesis. Neovascularization, Pathologic / metabolism. Vascular Endothelial Growth Factor A / biosynthesis
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(PMID = 19385471.001).
[ISSN]
1025-9589
[Journal-full-title]
Journal of Ayub Medical College, Abbottabad : JAMC
[ISO-abbreviation]
J Ayub Med Coll Abbottabad
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Pakistan
[Chemical-registry-number]
0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
65.
Reddy PS, Umesh S, Thota B, Tandon A, Pandey P, Hegde AS, Balasubramaniam A, Chandramouli BA, Santosh V, Rao MR, Kondaiah P, Somasundaram K:
PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value.
Cancer Biol Ther
; 2008 May;7(5):663-8
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[Title]
PBEF1/NAmPRTase/Visfatin: a potential
malignant astrocytoma
/glioblastoma serum marker with prognostic value.
Malignant
astrocytomas
comprise
anaplastic astrocytoma
(AA;
grade III
) and Glioblastoma (GBM;
grade
IV).
GBM is the most
malignant
with a median survival of 10-12 months in patients.
Using cDNA microarray based expression profiling of different grades of
astrocytomas
, we identified several fold increased levels of PBEF1 transcripts in GBM samples.
Further validation using real time RT-qPCR on an independent set of
tumor
samples (n=91) and normal brain samples (n=9), GBM specific higher expression of PBEF1 was confirmed.
We carried out ELISA analysis on serum samples of
astrocytoma
patients to determine whether this protein levels would correlate with the presence of
tumor
and
tumor
grade
.
Statistical analysis of these data indicates that in patients with
astrocytoma
, serum PBEF1 levels correlate with
tumor
grade
and is highest in GBM.
Immunohistochemical analysis of an independent set of 51 retrospective GBM cases with known survival data revealed that PBEF1 expression in the
tumor
tissue along with its co-expression with p53 was associated with poor survival.
Thus, we have identified PBEF1 as a potential
malignant astrocytoma
serum marker and prognostic indicator among GBMs.
[MeSH-major]
Astrocytoma
/ metabolism. Biomarkers,
Tumor
. Brain / metabolism. Brain Neoplasms / metabolism. Cytokines / physiology. Gene Expression Regulation, Neoplastic. Glioblastoma / metabolism. Nicotinamide Phosphoribosyltransferase / metabolism
[MeSH-minor]
Enzyme-Linked Immunosorbent Assay. Humans. Immunohistochemistry / methods. Oligonucleotide Array Sequence Analysis. Prognosis. Reverse Transcriptase Polymerase Chain Reaction.
Tumor
Suppressor Protein p53 / metabolism
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(PMID = 18728403.001).
[ISSN]
1555-8576
[Journal-full-title]
Cancer biology & therapy
[ISO-abbreviation]
Cancer Biol. Ther.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cytokines; 0 / Tumor Suppressor Protein p53; EC 2.4.2.12 / Nicotinamide Phosphoribosyltransferase; EC 2.4.2.12 / nicotinamide phosphoribosyltransferase, human
66.
Körner M, Reubi JC:
Neuropeptide Y receptors in primary human brain tumors: overexpression in high-grade tumors.
J Neuropathol Exp Neurol
; 2008 Aug;67(8):741-9
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[Title]
Neuropeptide Y receptors in primary human brain tumors: overexpression in high-
grade
tumors.
World Health Organization
Grade
IV glioblastomas showed a remarkably high expression of the NPY receptor subtype Y2 with respect to both incidence (83%) and density (mean, 4,886 dpm/mg tissue);
astrocytomas
World Health Organization Grades I to
III
and oligodendrogliomas also exhibited high Y2 incidences but low Y2 densities.
In conclusion, Y2 receptors in glioblastomas that are activated by NPY originating from intratumoral nerve fibers might mediate functional effects on the
tumor
cells.
Moreover, identification of the high expression of NPY receptors in high-
grade
gliomas and embryonal brain tumors provides the basis for in vivo targeting.
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(PMID = 18648328.001).
[ISSN]
0022-3069
[Journal-full-title]
Journal of neuropathology and experimental neurology
[ISO-abbreviation]
J. Neuropathol. Exp. Neurol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / BIIE 0246; 0 / Benzazepines; 0 / Iodine Radioisotopes; 0 / Peptides; 0 / Receptors, Neuropeptide Y; 37589-80-3 / Guanosine 5'-O-(3-Thiotriphosphate); 94ZLA3W45F / Arginine
67.
Wick W, Weller M:
[Anaplastic glioma. Neuropathology, molecular diagnostics and current study concepts].
Nervenarzt
; 2010 Aug;81(8):928-30, 932-5
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[Title]
[
Anaplastic
glioma. Neuropathology, molecular diagnostics and current study concepts].
According to the current WHO classification
anaplastic
gliomas comprise pure
astrocytomas
and oligodendrogliomas and mixed tumors.
This review summarizes findings, discusses problems and defines new questions from the phase
III
trials on
anaplastic
gliomas.
Therefore, marker profiles should be included into the next WHO brain
tumor
classification.
The current standard of care for first-line treatment in
anaplastic
gliomas is radiotherapy or chemotherapy.
Inclusion in this trial is already based on the WHO
grade
and the 1p/19q status and not on the histopathological subtype.
Furthermore,
anaplastic
gliomas are an important group of brain tumors for developing future molecular targeted therapies and should therefore be in the main focus of academic and industrial drug development, which aims at improved efficacy and avoiding long-term side-effects.
[MeSH-major]
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Oligodendroglioma / pathology
[MeSH-minor]
Antineoplastic Agents, Alkylating / therapeutic use. Brain / pathology. Chromosome Deletion. Clinical Trials as Topic. Clinical Trials, Phase
III
as Topic. Combined Modality Therapy. Cranial Irradiation. DNA Modification Methylases / genetics. DNA Mutational Analysis. DNA Repair Enzymes / genetics. Disease-Free Survival. Humans. Isocitrate Dehydrogenase / genetics. Promoter Regions, Genetic / genetics. Survival Rate.
Tumor
Suppressor Proteins / genetics
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Neurology. 2006 Jan 24;66(2):239-42
[
16434662.001
]
(PMID = 20635074.001).
[ISSN]
1433-0407
[Journal-full-title]
Der Nervenarzt
[ISO-abbreviation]
Nervenarzt
[Language]
ger
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0 / Tumor Suppressor Proteins; EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42. / IDH1 protein, human; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
68.
Tilleul P, Brignone M, Hassani Y, Taillandier L, Taillibert S, Cartalat-Carel S, Borget I, Chinot O:
[Prescription guidebook for temozolomide usage in brain tumors].
Bull Cancer
; 2009 May;96(5):579-89
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[Transliterated title]
Guide
de
prescription et
de
bon usage du témozolomide dans les tumeurs cérébrales.
Malignant
gliomas are the most frequent primary brain tumors in adults.
Temozolomide is an oral alkylating cytotoxic agent of second generation, used in the treatment of high-
grade
gliomas.
It is indicated in newly diagnosed glioblastoma multiform as well as in recurrent or progressive
malignant
gliomas, such as glioblastoma multiform or
anaplastic astrocytoma
.
The literature review was analysed by experts who determined the evidence level (A to E) according to the scale of recommendations adopted by the "Haute Autorité
de
santé--HAS--(French National Authority for Health)".
For high-
grade
and low-
grade
gliomas, based on the level of evidence from the literature, the use of temozolomide can be justified, with a B2 score attributed to these indications.
[MeSH-minor]
Age Factors.
Astrocytoma
/ drug therapy. Drug Administration Schedule. Drug Labeling. Glioblastoma / drug therapy. Humans
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(PMID = 19467988.001).
[ISSN]
1769-6917
[Journal-full-title]
Bulletin du cancer
[ISO-abbreviation]
Bull Cancer
[Language]
fre
[Publication-type]
English Abstract; Journal Article; Practice Guideline; Review
[Publication-country]
France
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
[Number-of-references]
55
69.
Yang SH, Hong YK, Yoon SC, Kim BS, Lee YS, Lee TK, Lee KS, Jeun SS, Kim MC, Park CK:
Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant glioma.
Oncol Rep
; 2007 Jun;17(6):1359-64
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[Title]
Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with
malignant
glioma.
We analyzed the clinical efficacy and toxicity of concurrent therapy as a first line modality for
malignant
glioma patients.
From 1998 to 2004, 39 patients, 22 with glioblastoma (GM), nine with
anaplastic astrocytoma
(AA), 7 with
anaplastic
oligodendroglioma (AO) and 1 with
anaplastic
oligodendro-
astrocytoma
(AOA) were enrolled in this study.
Grade III
/IV hematological toxicity was reduced from 25.6 to 13% after reduction of the dose of CCNU (75 mg/m(2)).
Modified concurrent chemoradiotherapy may be a feasible option for treating
malignant
glioma with acceptable toxicity.
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.
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VINCRISTINE
.
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.
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(PMID = 17487391.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine
70.
Ray WZ, Blackburn SL, Casavilca-Zambrano S, Barrionuevo C, Orrego JE, Heinicke H, Dowling JL, Perry A:
Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature.
J Neurooncol
; 2009 Sep;94(2):283-92
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[Title]
Clinicopathologic features of recurrent dysembryoplastic neuroepithelial
tumor
and rare
malignant
transformation: a report of 5 cases and review of the literature.
More recently, case reports have described
malignant
gliomas arising after irradiation and recurrences following subtotal or even gross total resection.
Nonetheless, a probably radiation induced
anaplastic astrocytoma
was encountered in one case 7 years after therapy.
These findings suggest that these patients may need closer follow-up than initially suggested, lending further support to the notion that this
tumor
behaves more like a benign
neoplasm
, rather than a dysplastic or hamartomatous lesion.
[MeSH-major]
Brain Neoplasms / pathology. Cell Transformation, Neoplastic / pathology.
Neoplasm
Recurrence, Local / diagnosis. Neoplasms, Neuroepithelial / pathology
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.
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[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
United States
[Number-of-references]
25
71.
Anselmo NP, Rey JA, Almeida LO, Custódio AC, Almeida JR, Clara CA, Santos MJ, Casartelli C:
Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma.
Genet Mol Res
; 2009;8(4):1257-63
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[Title]
Concurrent sequence variation of TP53 and TP73 genes in
anaplastic astrocytoma
.
Disruption or loss of
tumor
suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies.
Using PCR-SSCP and gene sequencing, we analyzed the TP53 and TP73 genes in a case of a
grade III
anaplastic astrocytoma
that progressed to glioblastoma.
The mutation found at exon 6 of the gene TP53 could be associated with the rapid tumoral progression found in this case, since the mutated p53 may inactivate the wild-
type
p53 and the p73alpha protein, which was conserved here, leading to an increase in cellular instability.
[MeSH-major]
Astrocytoma
/ genetics. Brain Neoplasms / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics.
Tumor
Suppressor Protein p53 / genetics.
Tumor
Suppressor Proteins / genetics
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(PMID = 19876867.001).
[ISSN]
1676-5680
[Journal-full-title]
Genetics and molecular research : GMR
[ISO-abbreviation]
Genet. Mol. Res.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Brazil
[Chemical-registry-number]
0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
72.
Jager B, Schuhmann MU, Schober R, Kortmann RD, Meixensberger J:
Induction of gliosarcoma and atypical meningioma 13 years after radiotherapy of residual pilocytic astrocytoma in childhood.
Pediatr Neurosurg
; 2008;44(2):153-8
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[Title]
Induction of gliosarcoma and atypical meningioma 13 years after radiotherapy of residual pilocytic
astrocytoma
in childhood.
BACKGROUND:
Malignant
transformation of pilocytic
astrocytomas
in children is rare and often linked to previous radiotherapy.
METHODS AND RESULTS: We report a patient who underwent subtotal resection of a right temporal and insular pilocytic
astrocytoma
at age 8 in 1988 followed by high-dose radiation therapy.
A local recurrence,
grade
WHO
III
, with signs of focal sarcomatous transformation, was subtotally resected 13 years later in 2001.
A new and fast growing right frontal meningioma,
grade
WHO II, was removed in 2003.
Another
tumor
mass reduction in 2005 was followed by stereotactic radiotherapy.
CONCLUSION: Most of the reported cases of
malignant
transformation of pilocytic
astrocytomas
received radiation therapy beforehand.
Irradiation-induced meningiomas in children are known to occur, however not following radiotherapy of low-
grade
hemispheric gliomas.
The presented case illustrates why adjuvant radiotherapy of residual pilocytic
astrocytoma
in children is not recommended anymore.
[MeSH-major]
Astrocytoma
/ radiotherapy. Gliosarcoma / etiology. Meningeal Neoplasms / etiology. Meningioma / etiology. Neoplasms, Radiation-Induced / etiology
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(PMID = 18230932.001).
[ISSN]
1423-0305
[Journal-full-title]
Pediatric neurosurgery
[ISO-abbreviation]
Pediatr Neurosurg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Switzerland
73.
Dreyfuss JM, Johnson MD, Park PJ:
Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers.
Mol Cancer
; 2009 Sep 04;8:71
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[Title]
Meta-analysis of glioblastoma multiforme versus
anaplastic astrocytoma
identifies robust gene markers.
BACKGROUND:
Anaplastic astrocytoma
(AA) and its more aggressive counterpart, glioblastoma multiforme (GBM), are the most common intrinsic brain tumors in adults and are almost universally fatal.
A deeper understanding of the molecular relationship of these
tumor
types is necessary to derive insights into the diagnosis, prognosis, and treatment of gliomas.
Although genomewide profiling of expression levels with microarrays can be used to identify differentially expressed genes between these
tumor
types, comparative studies so far have resulted in gene lists that show little overlap.
CONCLUSION: We have performed a meta-analysis of genome-scale mRNA expression data for 289 human
malignant
gliomas and have identified a list of >900 probe sets and >20 pathways that are significantly different between GBM and AA.
These feature lists could be utilized to aid in diagnosis, prognosis, and
grade
reduction of high-
grade
gliomas and to identify genes that were not previously suspected of playing an important role in glioma biology.
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Ann Vasc Surg. 2008 Mar;22(2):273-84
[
18346582.001
]
(PMID = 19732454.001).
[ISSN]
1476-4598
[Journal-full-title]
Molecular cancer
[ISO-abbreviation]
Mol. Cancer
[Language]
ENG
[Grant]
United States / NIGMS NIH HHS / GM / R01 GM082798; United States / NIH HHS / OD / DP2 OD002319; United States / NIH HHS / OD / DP2OD002319; United States / NLM NIH HHS / LM / U54 LM008748; United States / NLM NIH HHS / LM / U54LM008748
[Publication-type]
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
[Other-IDs]
NLM/ PMC2743637
74.
Zhang K, Li C, Liu Y, Li L, Ma X, Meng X, Feng D:
Evaluation of invasiveness of astrocytoma using 1H-magnetic resonance spectroscopy: correlation with expression of matrix metalloproteinase-2.
Neuroradiology
; 2007 Nov;49(11):913-9
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[Title]
Evaluation of invasiveness of
astrocytoma
using 1H-magnetic resonance spectroscopy: correlation with expression of matrix metalloproteinase-2.
INTRODUCTION: Even low-
grade astrocytomas
infiltrate the entire brain, a feature that precludes their successful therapy.
So to assess the invasive potential of
astrocytoma
is very important.
The aim of this study was determine whether there is a significant correlation between the results of (1)H-magnetic resonance spectroscopy ((1)H-MRS) and
tumor
invasive potential of
astrocytoma
, which is reflected by expression of matrix metalloproteinase-2 (MMP-2).
METHODS: The (1)H-MRS spectra of 41 histologically verified
astrocytomas
were obtained on
a 3
-T MR scanner.
According to the World Health Organization classification criteria for central nervous system tumors, there were 16 low-
grade astrocytomas
(2 pilocytic
astrocytomas
, 14
grade
II
astrocytomas
) and 25 high-
grade astrocytomas
(5
anaplastic
astrocytomas
, 20 glioblastomas).The choline/N-acetylaspartate (Cho/NAA) and choline/creatine (Cho/Cr) ratios were calculated.
Of the 41
astrocytomas
, 19 (8 low-
grade
and 11 high-
grade
) were analyzed immunohistochemically.
The correlations between metabolite ratios and the quantitative data from the immunohistochemical tests in the 19
astrocytomas
were determined.
RESULTS: The Cho/NAA and Cho/Cr ratios of high-
grade
astrocytoma
were both significantly greater than those of low-
grade
astrocytoma
(t = -6.222, P = 0.000; t = -6.533, P = 0.000, respectively).
MMP-2 COD values of high-
grade astrocytomas
were also significantly greater than those of low-
grade astrocytomas
(t = -5.892, P = 0.000).
CONCLUSION: (1)H-MRS is helpful in evaluating the invasiveness of
astrocytomas
and predicting prognosis preoperatively by determining the Cho/NAA and Cho/Cr ratios.
[MeSH-major]
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Magnetic Resonance Spectroscopy. Matrix Metalloproteinase 2 / metabolism
[MeSH-minor]
Adolescent. Adult. Aged. Aspartic Acid / analogs & derivatives. Aspartic Acid / metabolism. Choline / metabolism. Creatine / metabolism. Female. Humans. Male. Middle Aged.
Neoplasm
Invasiveness. Predictive Value of Tests. Treatment Outcome
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.
Hazardous Substances Data Bank.
(L)-ASPARTIC ACID
.
Hazardous Substances Data Bank.
CREATINE
.
Hazardous Substances Data Bank.
CHOLINE CHLORIDE
.
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(PMID = 17763847.001).
[ISSN]
0028-3940
[Journal-full-title]
Neuroradiology
[ISO-abbreviation]
Neuroradiology
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; EC 3.4.24.24 / Matrix Metalloproteinase 2; MU72812GK0 / Creatine; N91BDP6H0X / Choline
75.
Shrivastava RK, Epstein FJ, Perin NI, Post KD, Jallo GI:
Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis.
J Neurosurg Spine
; 2005 Mar;2(3):249-55
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Ependymoma was the most common
tumor
(83%), and 55% were located in the thoracic spine.
There were two deaths due
tumor
progression (both
malignant
tumors) and one recurrence (
anaplastic astrocytoma
).
All three patients in whom
malignant
astrocytomas
were diagnosed underwent postoperative radiation therapy.
The authors recommend motor evoked potential-guided aggressive microsurgical resection, because the long-term outcome of benign lesions is excellent (good functional recovery and no
tumor
recurrence).
[MeSH-minor]
Aged.
Astrocytoma
/ surgery. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Quality of Life. Retrospective Studies. Survival Rate. Treatment Outcome
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(PMID = 15796348.001).
[ISSN]
1547-5654
[Journal-full-title]
Journal of neurosurgery. Spine
[ISO-abbreviation]
J Neurosurg Spine
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
76.
Serrano J, Rayo JI, Infante JR, DomÃnguez L, GarcÃa-Bernardo L, Durán C, Fernández Portales I, Cabezudo JM:
Radioguided surgery in brain tumors with thallium-201.
Clin Nucl Med
; 2008 Dec;33(12):838-40
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RATIONALE:
Malignant
astrocytomas
show thallium uptake with a high target-to-background ratio, allowing the use of radioguided surgery.
METHOD: We report on 6 patients (3 men) diagnosed with
malignant astrocytoma
.
With the gamma probe we confirmed the
tumor
uptake, and a biopsy sample was taken.
After conventional
tumor
resection, we scanned the surgical bed with the gamma probe.
RESULTS: In all patients the biopsy confirmed a high-
grade
astrocytoma
.
In all cases we found residual uptake in the surgical bed that was confirmed as residual
tumor
by pathologic examination.
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(PMID = 19033782.001).
[ISSN]
1536-0229
[Journal-full-title]
Clinical nuclear medicine
[ISO-abbreviation]
Clin Nucl Med
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Thallium Radioisotopes
77.
Cabrera-Muñoz E, González-Arenas A, Saqui-Salces M, Camacho J, Larrea F, GarcÃa-Becerra R, Camacho-Arroyo I:
Regulation of progesterone receptor isoforms content in human astrocytoma cell lines.
J Steroid Biochem Mol Biol
; 2009 Jan;113(1-2):80-4
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[Title]
Regulation of progesterone receptor isoforms content in human
astrocytoma
cell lines.
Both PR isoforms have been detected in human
astrocytomas
, the most common and aggressive primary brain tumours, but their regulation and function are unknown.
We studied the effects of estradiol, progesterone and their receptor antagonists (ICI 182,780 and RU 486) on PR isoforms content in U373 and D54 human
astrocytoma
cell lines, respectively derived from grades
III
and IV
astrocytomas
, by Western blot analysis.
Our results suggest a differential PR isoforms regulation depending on the evolution
grade
of human
astrocytoma
cells, and an inhibitory role of PR-A on progesterone effects on
astrocytomas
cell growth.
[MeSH-major]
Astrocytoma
/ metabolism. Receptors, Progesterone / metabolism
[MeSH-minor]
Cell Line,
Tumor
. Cell Proliferation. Humans. Protein Isoforms / metabolism. Transfection
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(PMID = 19095059.001).
[ISSN]
0960-0760
[Journal-full-title]
The Journal of steroid biochemistry and molecular biology
[ISO-abbreviation]
J. Steroid Biochem. Mol. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Protein Isoforms; 0 / Receptors, Progesterone
78.
Xiang C, Sarid R, Cazacu S, Finniss S, Lee HK, Ziv-Av A, Mikkelsen T, Brodie C:
Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells.
Biochem Biophys Res Commun
; 2007 Oct 26;362(3):612-8
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In contrast, RTVP-1 and RTVP-1b showed similar patterns of expression in
astrocytic
tumors; highly expressed in glioblastomas as compared to normal brains, low-
grade astrocytomas
and
anaplastic
oligodendrogliomas.
[MeSH-major]
Brain Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Glioma / metabolism.
Neoplasm
Proteins / biosynthesis.
Neoplasm
Proteins / genetics. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics
[MeSH-minor]
Alternative Splicing. Amino Acid Sequence. Base Sequence. Cell Line,
Tumor
. Cell Movement. Cell Proliferation. Cloning, Molecular. Humans. Molecular Sequence Data. Protein Isoforms. Tissue Distribution
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(PMID = 17825796.001).
[ISSN]
0006-291X
[Journal-full-title]
Biochemical and biophysical research communications
[ISO-abbreviation]
Biochem. Biophys. Res. Commun.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA-R21-96965; United States / NCI NIH HHS / CA / R24 CA095809
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / GLIPR1 protein, human; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Protein Isoforms
79.
Argyriou AA, Giannopoulou E, Kalofonos HP:
Angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas.
Oncology
; 2009;77(1):1-11
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[Title]
Angiogenesis and anti-angiogenic molecularly targeted therapies in
malignant
gliomas.
Angiogenesis is considered to be a regulating factor of vascular development and growth for
malignant
gliomas, including glioblastoma multiforme (GBM) and
anaplastic
astrocytomas
.
The VEGF/VEGFR-2 is the predominant angiogenic signalling pathway in
malignant
gliomas.
Our aim is to review current knowledge on angiogenesis as a molecular pathogenetic mechanism of
malignant
gliomas and to critically look at and discuss antiangiogenic molecularly targeted therapies for these brain malignancies.
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[Copyright]
Copyright 2009 S. Karger AG, Basel.
(PMID = 19439998.001).
[ISSN]
1423-0232
[Journal-full-title]
Oncology
[ISO-abbreviation]
Oncology
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Angiogenesis Inhibitors
[Number-of-references]
98
80.
Arakawa Y, Tachibana O, Hasegawa M, Miyamori T, Yamashita J, Hayashi Y:
Frequent gene amplification and overexpression of decoy receptor 3 in glioblastoma.
Acta Neuropathol
; 2005 Mar;109(3):294-8
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DcR3 has been demonstrated to produce a secreted member of the
tumor
necrosis factor receptor superfamily that negatively regulates Fas-mediated apoptosis.
In this study we examined DcR3 gene amplification, DcR3 mRNA expression, and DcR3 protein expression in 46 human
astrocytic
brain tumors by quantitative genomic PCR, quantitative reverse transcription-PCR, and immunohistochemistry, respectively.
The DcR3 gene amplification was detected in none of 6 (0%) low-
grade astrocytomas
, 1 of 16 (6%)
anaplastic
astrocytomas
, and 6 of 24 ( 25%) glioblastomas.
We thus concluded that high DcR3 mRNA expression and protein expression may be positively related to the gene amplification in
astrocytic
brain tumors, especially glioblastomas.
Further, we speculated that the DcR3 gene amplification with overexpression may be responsible for
malignant
features in glioblastomas.
[MeSH-minor]
Adolescent. Adult. Aged. Child. Female. Humans. Immunohistochemistry / methods. Male. Middle Aged. RNA, Messenger / biosynthesis. Receptors,
Tumor
Necrosis Factor. Receptors,
Tumor
Necrosis Factor, Member 6b. Reverse Transcriptase Polymerase Chain Reaction / methods
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(PMID = 15627206.001).
[ISSN]
0001-6322
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Membrane Glycoproteins; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Receptors, Tumor Necrosis Factor; 0 / Receptors, Tumor Necrosis Factor, Member 6b; 0 / TNFRSF6B protein, human
81.
Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, Tamgüney T, Baumber R, Parsons R, Lamborn KR, Berger MS, Wrensch MR, Haas-Kogan DA, Stokoe D:
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma.
Neuro Oncol
; 2007 Jul;9(3):271-9
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[Title]
Methylation of the PTEN promoter defines low-
grade
gliomas and secondary glioblastoma.
Glioblastoma multiforme (GBM) can present as either
de
novo or secondary tumors arising from previously diagnosed low-
grade
gliomas.
Although these
tumor
types are phenotypically indistinguishable,
de
novo and secondary GBMs are associated with distinct genetic characteristics.
PTEN mutations, which result in activation of the phosphoinositide 3-kinase (PI3K) signal transduction pathway, are frequent in
de
novo but not in secondary GBMs or their antecedent low-
grade
tumors.
Results we present here show that
grade
II
astrocytomas
, oligodendrogliomas, and oligoastrocytomas commonly display methylation of the PTEN promoter, a finding that is absent in nontumor brain specimens and rare in
de
novo GBMs.
Our results also demonstrate frequent methylation of the PTEN promoter in
grade III astrocytomas
and secondary GBMs, consistent with the hypothesis that these tumors arise from lower
grade
precursors.
PTEN methylation is rare in
de
novo GBMs and is mutually exclusive with PTEN mutations.
We conclude that methylation of the PTEN promoter may represent an alternate mechanism by which PI3K signaling is increased in
grade
II and
III
gliomas as well as secondary GBMs, a finding that offers new therapeutic approaches in these patients.
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(PMID = 17504928.001).
[ISSN]
1522-8517
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P50 CA97257; United States / NCI NIH HHS / CA / R01 CA52689; United States / NCI NIH HHS / CA / P50 CA097257; United States / NCI NIH HHS / CA / R01 CA082783-06; United States / NCI NIH HHS / CA / R01 CA082783; United States / NCI NIH HHS / CA / CA082783-06; United States / NCI NIH HHS / CA / R01 CA052689
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Genetic Markers; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
[Other-IDs]
NLM/ PMC1907411
82.
Khalatbari M, Borghei-Razavi H, Shayanfar N, Behzadi AH, Sepehrnia A:
Collision tumor of meningioma and malignant astrocytoma.
Pediatr Neurosurg
; 2010;46(5):357-61
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[Title]
Collision
tumor
of meningioma and
malignant astrocytoma
.
The pathology of tumors reported collision tumors composed of meningioma and
malignant astrocytoma
.
[MeSH-major]
Astrocytoma
/ surgery. Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery
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[Copyright]
Copyright © 2011 S. Karger AG, Basel.
(PMID = 21389747.001).
[ISSN]
1423-0305
[Journal-full-title]
Pediatric neurosurgery
[ISO-abbreviation]
Pediatr Neurosurg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Switzerland
83.
Pavon LF, Marti LC, Sibov TT, Malheiros SM, Oliveira DM, Guilhen DD, Camargo-Mathias MI, Amaro Junior E, Gamarra LF:
The ultrastructural study of tumorigenic cells using nanobiomarkers.
Cancer Biother Radiopharm
; 2010 Jun;25(3):289-98
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Despite recent advances, patients with
malignant
brain tumors still have a poor prognosis.
Glioblastoma (WHO
grade
4
astrocytoma
), the most
malignant
brain
tumor
, represents 50% of all
astrocytomas
, with a median survival rate of <1 year.
The process of
tumor
cell labeling using nanoparticles can successfully contribute to the identification of tumorigenic cells and consequently for better understanding of glioblastoma genesis and recurrence.
In addition, this method may help further studies in
tumor
imaging, diagnosis, and prognostic markers detection.
[MeSH-minor]
Antibodies, Monoclonal / chemistry. Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / metabolism. Antigens, CD / immunology. Antigens, CD / metabolism. Antigens, CD29 / immunology. Antigens, CD29 / metabolism. Antigens, CD44 / immunology. Antigens, CD44 / metabolism. Biomarkers / analysis. Biomarkers / chemistry. Cell Line,
Tumor
. Cell Membrane / metabolism. Cell Nucleus / metabolism. Cytoplasm / metabolism. Cytoplasmic Vesicles / metabolism. Endocytosis / immunology. Flow Cytometry. Forkhead Transcription Factors / chemistry. Forkhead Transcription Factors / metabolism. Glycoproteins / immunology. Glycoproteins / metabolism. Humans. Immunophenotyping. Magnetite Nanoparticles / chemistry. Microscopy, Electron, Transmission. Nanomedicine / methods. Peptides / immunology. Peptides / metabolism. Quantum Dots. Receptors, Cell Surface / immunology. Receptors, Cell Surface / metabolism.
Tumor
Cells, Cultured
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 20578834.001).
[ISSN]
1557-8852
[Journal-full-title]
Cancer biotherapy & radiopharmaceuticals
[ISO-abbreviation]
Cancer Biother. Radiopharm.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / AC133 antigen; 0 / Antibodies, Monoclonal; 0 / Antigens, CD; 0 / Antigens, CD29; 0 / Antigens, CD44; 0 / Biomarkers; 0 / CD44 protein, human; 0 / ENG protein, human; 0 / FOXM1 protein, human; 0 / Forkhead Transcription Factors; 0 / Glycoproteins; 0 / Magnetite Nanoparticles; 0 / Peptides; 0 / Receptors, Cell Surface
84.
Frenay MP, Fontaine D, Vandenbos F, Lebrun C:
First-line nitrosourea-based chemotherapy in symptomatic non-resectable supratentorial pure low-grade astrocytomas.
Eur J Neurol
; 2005 Sep;12(9):685-90
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[Title]
First-line nitrosourea-based chemotherapy in symptomatic non-resectable supratentorial pure low-
grade astrocytomas
.
At the present time, there are no proven beneficial effects of chemotherapy (CT) for the treatment of pure low-
grade astrocytomas
.
Brain radiotherapy (RT) still remains the standard treatment in order to reduce or delay
tumor
progression or symptoms, despite possible long-term neurologic complications.
We report 10 patients, with histologically proven pure low-
grade
fibrillary
astrocytomas
, to which we administered a first-line nitrosourea-based CT.
CT was well tolerated; all patients developed myelosuppression with 40% of
grade III
/IV hematotoxicity.
These results demonstrate that some patients with symptomatic non-resectable fibrillary low-
grade astrocytomas
can be treated with up-front CT to improve their neurologic status.
[MeSH-major]
Astrocytoma
/ therapy. Brain Neoplasms / therapy. Drug Therapy / methods. Nitrosourea Compounds / therapeutic use
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(PMID = 16128869.001).
[ISSN]
1351-5101
[Journal-full-title]
European journal of neurology
[ISO-abbreviation]
Eur. J. Neurol.
[Language]
eng
[Publication-type]
Clinical Trial; Comparative Study; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Nitrosourea Compounds
85.
Krzyszkowski T, Dziedzic T, Czepko R, Szczudlik A:
Decreased levels of interleukin-10 and transforming growth factor-beta 2 in cerebrospinal fluid of patients with high grade astrocytoma.
Neurol Res
; 2008 Apr;30(3):294-6
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[Title]
Decreased levels of interleukin-10 and transforming growth factor-beta 2 in cerebrospinal fluid of patients with high
grade
astrocytoma
.
It is unknown if production of these cytokines is limited to the site of
tumor
or these molecules are also released to cerebrospinal fluid and blood.
The goal of our study was to determine if patients with
astrocytoma
have increased levels of IL-10 and TGF-beta 2 in cerebrospinal fluid (CSF) and serum.
METHODS: CSF and serum samples were taken from 16 patients with
astrocytoma
of
grade III
or
grade
IV according to the WHO classification and from 28 age- and gender-matched controls (patients with normal pressure hydrocephalus or with lumbar disk herniation).
Patients with
astrocytoma
had decreased levels of IL-10 (0.9 +/- 1.2 versus 3.5 +/- 9.2 pg/ml, p=0.01) and TGF-beta 2 (0.0 +/- 0.0 versus 5.4 +/- 9.4 pg/ml, p=0.05) in CSF compared to controls.
Because serum IL-10 and TGF-beta 2 levels are similar in patients with
astrocytoma
and in controls, these cytokines are probably not directly involved in peripheral monocyte and T cell deactivation.
[MeSH-major]
Astrocytoma
/ blood.
Astrocytoma
/ cerebrospinal fluid. Interleukin-10 / blood. Interleukin-10 / cerebrospinal fluid. Transforming Growth Factor beta2 / blood. Transforming Growth Factor beta2 / cerebrospinal fluid
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(PMID = 17848206.001).
[ISSN]
0161-6412
[Journal-full-title]
Neurological research
[ISO-abbreviation]
Neurol. Res.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Transforming Growth Factor beta2; 130068-27-8 / Interleukin-10
86.
Wagner S, Csatary CM, Gosztonyi G, Koch HC, Hartmann C, Peters O, Hernáiz-Driever P, Théallier-Janko A, Zintl F, Längler A, Wolff JE, Csatary LK:
Combined treatment of pediatric high-grade glioma with the oncolytic viral strain MTH-68/H and oral valproic acid.
APMIS
; 2006 Oct;114(10):731-43
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[Title]
Combined treatment of pediatric high-
grade
glioma with the oncolytic viral strain MTH-68/H and oral valproic acid.
The case of a 12-year-old boy with
anaplastic astrocytoma
of the left thalamus is reported.
Postoperative irradiation and chemotherapy could not repress
tumor
progression; therefore, treatment was undertaken with an oncolytic virus, MTH-68/H, an attenuated strain of Newcastle disease virus (NDV), and valproic acid (VPA), an antiepileptic drug, which also has antineoplastic properties.
This treatment resulted in a far-reaching regression of the thalamic glioma, but 4 months later a new
tumor
manifestation, an extension of the thalamic
tumor
, appeared in the wall of the IVth ventricle, which required a second neurosurgical intervention.
Under continuous MTH-68/H - VPA administration the thalamic
tumor
remained under control, but the rhombencephalic one progressed relentlessly and led to the fatal outcome.
In the final stage, a third
tumor
manifestation appeared in the left temporal lobe.
The possible reasons for the antagonistic behavior of the three manifestations of the same
type
of glioma to the initially most successful therapy are discussed.
The comparative histological study of the thalamic and rhombencephalic
tumor
manifestations revealed that MTH-68/H treatment induces, similar to in vitro observations, a massive apoptotic
tumor
cell decline.
In the rhombencephalic
tumor
, in and around the declining
tumor
cells, NDV antigen could be demonstrated immunohistochemically, and virus particles have been found in the cytoplasm of
tumor
cells at electron microscopic investigation.
[MeSH-major]
Anticonvulsants / therapeutic use.
Astrocytoma
/ drug therapy.
Astrocytoma
/ therapy. Brain Neoplasms / therapy. Valproic Acid / therapeutic use. Viral Vaccines / therapeutic use
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.
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Hazardous Substances Data Bank.
VALPROIC ACID
.
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.
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(PMID = 17004977.001).
[ISSN]
0903-4641
[Journal-full-title]
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
[ISO-abbreviation]
APMIS
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Denmark
[Chemical-registry-number]
0 / Anticonvulsants; 0 / Antigens, Viral; 0 / Newcastle disease virus vaccine MTH-68-H; 0 / Viral Vaccines; 614OI1Z5WI / Valproic Acid
87.
Ehling R, Sterlacci W, Maier H, Berger T:
A 45-year old male with left-sided hemihypesthesia.
Brain Pathol
; 2010 Mar;20(2):515-8
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Extensive immunological and radiological investigations were not able to differentiate between an intrinsic brain
tumor
and a demyelinating disease.
Stereotactic biopsies of the brainstem were performed; the findings of abundant Rosenthal fibers, interjacent spindle-shaped and gemistocytic cells partially with dark and irregularly formed nuclei favored primarily the diagnosis of
a malignant astrocytoma
, although a demyelinating disease could not be definitely excluded.
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(PMID = 20438473.001).
[ISSN]
1750-3639
[Journal-full-title]
Brain pathology (Zurich, Switzerland)
[ISO-abbreviation]
Brain Pathol.
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
Switzerland
[Chemical-registry-number]
0Z5B2CJX4D / Fluorodeoxyglucose F18
88.
Capper D, Weissert S, Balss J, Habel A, Meyer J, Jäger D, Ackermann U, Tessmer C, Korshunov A, Zentgraf H, Hartmann C, von Deimling A:
Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors.
Brain Pathol
; 2010 Jan;20(1):245-54
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Heterozygous point mutations of isocitrate dehydrogenase (IDH)1 codon 132 are frequent in
grade
II and
III
gliomas.
Here we investigate the capability of this antibody to differentiate wild
type
and mutated IDH1 protein in central nervous system (CNS) tumors by Western blot and immunohistochemistry.
Intriguing is the ability of mIDH1R132H to detect single infiltrating
tumor
cells.
The very high frequency and the distribution of this mutation among specific brain
tumor
entities allow the highly sensitive and specific discrimination of various tumors by immunohistochemistry, such as
anaplastic astrocytoma
from primary glioblastoma or diffuse
astrocytoma
World Health Organization (WHO)
grade
II from pilocytic
astrocytoma
or ependymoma.
[MeSH-major]
Astrocytoma
/ genetics. Brain Neoplasms / enzymology. Brain Neoplasms / genetics. Ependymoma / genetics. Glioma / enzymology. Glioma / genetics. Isocitrate Dehydrogenase / genetics. Isocitrate Dehydrogenase / immunology
[MeSH-minor]
Adolescent. Adult. Aged. Antigen-Antibody Reactions. Blotting, Western. Child. Child, Preschool. Cloning, Molecular. DNA,
Neoplasm
/ biosynthesis. DNA,
Neoplasm
/ genetics. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Mutation / genetics. Mutation / physiology. Protein Biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Young Adult
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(PMID = 19903171.001).
[ISSN]
1750-3639
[Journal-full-title]
Brain pathology (Zurich, Switzerland)
[ISO-abbreviation]
Brain Pathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / DNA, Neoplasm; EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42. / IDH1 protein, human
89.
Schittenhelm J, Mittelbronn M, Nguyen TD, Meyermann R, Beschorner R:
WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes.
Brain Pathol
; 2008 Jul;18(3):344-53
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[Title]
WT1 expression distinguishes
astrocytic tumor
cells from normal and reactive astrocytes.
Particularly in small brain biopsies, it might be difficult to distinguish reactive astrogliosis from low-
grade
or infiltration zones of high-
grade astrocytomas
.
Recently, the over-expression of Wilms'
tumor
gene product WT1 was reported in
astrocytic tumor
cells.
Therefore, we investigated WT1 expression in paraffin-embedded brain sections from 28 controls, 48 cases with astrogliosis of various etiology and 219
astrocytomas
[World Health Organization (WHO) grades I-IV] by immunohistochemistry.
In
astrocytomas
, WT1-positive
tumor
cells were found in pilocytic
astrocytomas
(66.7% of cases), diffuse
astrocytomas
(52.7%) WHO
grade
II (52.7%),
anaplastic
astrocytomas
(83.4%) and glioblastomas (98.1%).
Overall, the majority of all
astrocytic
neoplasms (84.5%) expressed WT1.
Establishing a cut-off value of 0% immunoreactive
tumor
cells served to recognize neoplastic astrocytes with 100% specificity and 68% sensitivity and was associated with positive and negative predictive values of 1 and 0.68, respectively.
[MeSH-major]
Astrocytes / metabolism.
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Gliosis / metabolism. WT1 Proteins / biosynthesis
[MeSH-minor]
Adult. Aged. Biomarkers,
Tumor
/ analysis. Endothelial Cells / metabolism. Female. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged
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(PMID = 18371184.001).
[ISSN]
1015-6305
[Journal-full-title]
Brain pathology (Zurich, Switzerland)
[ISO-abbreviation]
Brain Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / WT1 Proteins
90.
Niizuma K, Fujimura M, Kumabe T, Tominaga T:
Malignant transformation of high-grade astrocytoma associated with neurocysticercosis in a patient with Turcot syndrome.
J Clin Neurosci
; 2007 Jan;14(1):53-5
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[Title]
Malignant
transformation of high-
grade
astrocytoma
associated with neurocysticercosis in a patient with Turcot syndrome.
A 45-year-old woman with
anaplastic astrocytoma
was clinically diagnosed with Turcot syndrome, and subsequently developed simultaneous neurocysticercosis and
malignant
transformation to glioblastoma.
The clinical course and histological findings suggest that the parasitic infection and/or genetic changes contributed to the
malignant
transformation of the
astrocytic
tumour.
[MeSH-major]
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Glioblastoma / pathology. Neurocysticercosis / pathology
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(PMID = 17138070.001).
[ISSN]
0967-5868
[Journal-full-title]
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
[ISO-abbreviation]
J Clin Neurosci
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Scotland
91.
Calli C, Kitis O, Yunten N, Yurtseven T, Islekel S, Akalin T:
Perfusion and diffusion MR imaging in enhancing malignant cerebral tumors.
Eur J Radiol
; 2006 Jun;58(3):394-403
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[Title]
Perfusion and diffusion MR imaging in enhancing
malignant
cerebral tumors.
OBJECTIVE: Common contrast-enhancing
malignant
tumors of the brain are glioblastoma multiforme (GBMs),
anaplastic
astrocytomas
(AAs), metastases, and lymphomas, all of which have sometimes similar conventional MRI findings.
Our aim was to evaluate the role of perfusion MR imaging (PWI) and diffusion-weighted imaging (DWI) in the differentiation of these contrast-enhancing
malignant
cerebral tumors.
Minimum ADC values (ADC(min)) of each
tumor
was later calculated from ADC map images.
PWI was applied using dynamic susceptibility contrast technique and maximum relative cerebral blood volume (rCBV(max)) was calculated from each
tumor
, given in ratio with contralateral normal white matter.
CONCLUSION: Combination of DWI and PWI, with ADC(min) and rCBV(max) calculations, may aid routine MR imaging in the differentiation of common cerebral contrast-enhancing
malignant
tumors.
[MeSH-major]
Astrocytoma
/ diagnosis. Brain Neoplasms / diagnosis. Diffusion Magnetic Resonance Imaging / methods. Glioblastoma / diagnosis. Image Enhancement / methods. Lymphoma / diagnosis. Magnetic Resonance Angiography / methods
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(PMID = 16527438.001).
[ISSN]
0720-048X
[Journal-full-title]
European journal of radiology
[ISO-abbreviation]
Eur J Radiol
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Contrast Media
92.
Doherty MJ, Hampson NB:
Partial seizure provoked by hyperbaric oxygen therapy: possible mechanisms and implications.
Epilepsia
; 2005 Jun;46(6):974-6
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We report a patient after resection of
anaplastic astrocytoma
and 5,580 cGy of total external-beam radiation treatments with brain radiation necrosis who underwent HBO2 therapy and developed a partial seizure during treatment.
[MeSH-minor]
Astrocytoma
/ radiotherapy.
Astrocytoma
/ surgery. Brain Neoplasms / radiotherapy. Brain Neoplasms / surgery. Combined Modality Therapy. Humans. Male. Middle Aged. Necrosis / etiology. Necrosis / pathology. Necrosis / therapy. Radiotherapy, Conformal / adverse effects
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(PMID = 15946345.001).
[ISSN]
0013-9580
[Journal-full-title]
Epilepsia
[ISO-abbreviation]
Epilepsia
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
93.
Stupp R, Reni M, Gatta G, Mazza E, Vecht C:
Anaplastic astrocytoma in adults.
Crit Rev Oncol Hematol
; 2007 Jul;63(1):72-80
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[Title]
Anaplastic astrocytoma
in adults.
Anaplastic astrocytoma
is an uncommon disease in the adult population.
Based on randomized data available, chemotherapy has consistently failed to improve the outcome of patients with
anaplastic astrocytoma
, while a meta-analysis showed a small, but significant improvement in survival favouring the use of chemotherapy.
In recurrent disease, chemotherapy with temozolomide has been proven to be active and well-tolerated in phase II trials, but no comparative phase
III
trials of other cytotoxic drugs have been conducted.
[MeSH-major]
Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ drug therapy. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives
[MeSH-minor]
Adolescent. Adult. Aged. Clinical Trials as Topic. Clinical Trials, Phase II as Topic. Female. Humans. Incidence. Male. Middle Aged.
Neoplasm
Recurrence, Local / drug therapy. Prognosis. Risk Factors. Survival Analysis
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.
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The Weizmann Institute of Science GeneCards and MalaCards databases.
gene/protein/disease-specific - MalaCards for anaplastic astrocytoma
.
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DACARBAZINE
.
The Lens.
Cited by Patents in
.
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(PMID = 17478095.001).
[ISSN]
1040-8428
[Journal-full-title]
Critical reviews in oncology/hematology
[ISO-abbreviation]
Crit. Rev. Oncol. Hematol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Review
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
[Number-of-references]
69
94.
Das A, Simmons C, Danielpour M:
A congenital brain tumor associated with assisted in vitro fertilization. Case report.
J Neurosurg
; 2005 Nov;103(5 Suppl):451-3
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[Title]
A congenital brain
tumor
associated with assisted in vitro fertilization. Case report.
In this report the authors describe the clinical features of a rare neonatal
anaplastic astrocytoma
in the setting of in vitro fertilization (IVF).
Grosstotal resection of an
anaplastic astrocytoma
was followed by chemotherapy with temozolomide and vincristine.
[MeSH-major]
Astrocytoma
/ congenital. Brain Neoplasms / congenital. Fertilization in Vitro / adverse effects
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.
Hazardous Substances Data Bank.
DACARBAZINE
.
Hazardous Substances Data Bank.
VINCRISTINE
.
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[CommentIn]
J Neurosurg. 2007 May;106(5 Suppl):418; author reply 418-9
[
17566216.001
]
(PMID = 16302619.001).
[ISSN]
0022-3085
[Journal-full-title]
Journal of neurosurgery
[ISO-abbreviation]
J. Neurosurg.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
5J49Q6B70F / Vincristine; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
95.
Gururangan S, Frankel W, Broaddus R, Clendenning M, Senter L, McDonald M, Eastwood J, Reardon D, Vredenburgh J, Quinn J, Friedman HS:
Multifocal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS2 mutation.
Neuro Oncol
; 2008 Feb;10(1):93-7
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[Title]
Multifocal
anaplastic astrocytoma
in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS2 mutation.
We describe the case of a patient with transcobalamin II deficiency, hypogammaglobulinemia, absent corpus callosum, and mental retardation who presented at an early age with colorectal cancer and multifocal
anaplastic astrocytoma
.
He was found to have a possible germline mutation of the PMS2 gene, as evidenced by absent protein expression in both normal and
tumor
tissues.
[MeSH-major]
Abnormalities, Multiple / genetics. Adenosine Triphosphatases / genetics.
Astrocytoma
/ genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. DNA Repair Enzymes / genetics. DNA-Binding Proteins / genetics
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.
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.
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.
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[Cites]
Vitam Horm. 2000;59:337-66
[
10714245.001
]
[Cites]
Oncogene. 2000 Mar 23;19(13):1719-23
[
10763829.001
]
[Cites]
Am J Pathol. 2002 Jun;160(6):1953-8
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12057899.001
]
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N Engl J Med. 2003 Mar 6;348(10):919-32
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Am J Hum Genet. 2004 May;74(5):954-64
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Cancer Res. 2004 Jul 15;64(14):4721-7
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Cancer Res. 2006 Aug 1;66(15):7810-7
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Nature. 1994 Sep 1;371(6492):75-80
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8072530.001
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7661930.001
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Arch Dis Child. 1995 Mar;72(3):237-8
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Curr Probl Surg. 2005 Apr;42(4):195-256
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[
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]
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Hum Mutat. 2006 May;27(5):490-5
[
16619239.001
]
[Cites]
Br J Haematol. 1992 Jan;80(1):117-20
[
1536799.001
]
(PMID = 17993636.001).
[ISSN]
1522-8517
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA-Binding Proteins; 0 / Transcobalamins; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / PMS2 protein, human; EC 6.5.1.- / DNA Repair Enzymes
[Other-IDs]
NLM/ PMC2600843
96.
Lee EJ, Lee SK, Agid R, Bae JM, Keller A, Terbrugge K:
Preoperative grading of presumptive low-grade astrocytomas on MR imaging: diagnostic value of minimum apparent diffusion coefficient.
AJNR Am J Neuroradiol
; 2008 Nov;29(10):1872-7
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[Title]
Preoperative grading of presumptive low-
grade astrocytomas
on MR imaging: diagnostic value of minimum apparent diffusion coefficient.
BACKGROUND AND PURPOSE: Histopathologic
grade
of glial tumors is inversely correlated with the minimum apparent diffusion coefficient (ADC).
We assessed the diagnostic values of minimum ADC for preoperative grading of supratentorial
astrocytomas
that were diagnosed as low-
grade astrocytomas
on conventional MR imaging.
MATERIALS AND METHODS: Among 118 patients with
astrocytomas
(WHO grades II-IV), 16 who showed typical MR imaging findings of low-
grade
supratentorial
astrocytomas
on conventional MR imaging were included.
The minimum ADC value of each
tumor
was determined from several regions of interest in the
tumor
on ADC maps.
To assess the relationship between the minimum ADC and
tumor
grade
, we performed the Mann-Whitney U test.
A receiver operating characteristic (ROC) analysis was used to determine the cutoff value of the minimum ADC that had the best combination of sensitivity and specificity for distinguishing low- and high-
grade astrocytomas
.
RESULTS: Eight of the 16 patients (50%) were confirmed as having high-
grade astrocytomas
(WHO grades
III
and IV), and the other 8 patients were confirmed as having low-
grade astrocytomas
(WHO
grade
II).
The median minimum ADC of the high-
grade
astrocytoma
(1.035 x 10(-3) mm(2) .
sec(-1)) group was significantly lower than that of the low-
grade
astrocytoma
group (1.19 x 10(-3) mm(2) .
CONCLUSION: Measuring minimum ADC can provide valuable diagnostic information for the preoperative grading of presumptive low-
grade
supratentorial
astrocytomas
.
[MeSH-major]
Algorithms.
Astrocytoma
/ diagnosis. Brain Neoplasms / diagnosis. Image Interpretation, Computer-Assisted / methods. Magnetic Resonance Imaging / methods
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.
MedlinePlus Health Information.
consumer health - MRI Scans
.
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(PMID = 18719036.001).
[ISSN]
1936-959X
[Journal-full-title]
AJNR. American journal of neuroradiology
[ISO-abbreviation]
AJNR Am J Neuroradiol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
97.
Roselli F, Pisciotta NM, Aniello MS, Niccoli-Asabella A, Defazio G, Livrea P, Rubini G:
Brain F-18 Fluorocholine PET/CT for the assessment of optic pathway glioma in neurofibromatosis-1.
Clin Nucl Med
; 2010 Oct;35(10):838-9
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Magnetic resonance imaging, magnetic resonance spectroscopy (MRS), and F-18 fluorocholine revealed a splenial mass with imaging features compatible with
malignant astrocytoma
.
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.
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(PMID = 20838306.001).
[ISSN]
1536-0229
[Journal-full-title]
Clinical nuclear medicine
[ISO-abbreviation]
Clin Nucl Med
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / fluorocholine; N91BDP6H0X / Choline
98.
Terasaki M, Bouffet E, Katsuki H, Fukushima S, Shigemori M:
Pilot trial of the rate of response, safety, and tolerability of temozolomide and oral VP-16 in patients with recurrent or treatment-induced malignant central nervous system tumors.
Surg Neurol
; 2008 Jan;69(1):46-50
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[Title]
Pilot trial of the rate of response, safety, and tolerability of temozolomide and oral VP-16 in patients with recurrent or treatment-induced
malignant
central nervous system tumors.
METHODS: Eleven patients with recurrent or treatment-induced
malignant
CNS tumors, including treatment-induced PNET (in 1 patient), brainstem glioma (in 3 patients; 1 with treatment-induced, 2 with recurrence), recurrent
anaplastic astrocytoma
(in 3 patients), and recurrent glioblastoma (in 4 patients) were evaluated in a pilot study of TMZ and oral VP-16 chemotherapy.
The histologic subtype of the
tumor
, its location, and its maximum response to chemotherapy did not have an impact on the duration of disease control.
CONCLUSION: This limited pilot study confirms the innocuousness and the activity of the combination of TMZ and oral VP-16 in recurrent
malignant
brain tumors.
This promising activity warrants further investigation of this combination in larger phase II or
III
studies.
[MeSH-major]
Antineoplastic Agents / administration & dosage. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Etoposide / administration & dosage.
Neoplasm
Recurrence, Local / drug therapy. Neoplasms, Neuroepithelial / drug therapy. Neoplasms, Second Primary / drug therapy
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.
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ETOPOSIDE
.
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DACARBAZINE
.
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(PMID = 18054615.001).
[ISSN]
0090-3019
[Journal-full-title]
Surgical neurology
[ISO-abbreviation]
Surg Neurol
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 6PLQ3CP4P3 / Etoposide; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
99.
Zarkovic K, Juric G, Waeg G, Kolenc D, Zarkovic N:
Immunohistochemical appearance of HNE-protein conjugates in human astrocytomas.
Biofactors
; 2005;24(1-4):33-40
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[Title]
Immunohistochemical appearance of HNE-protein conjugates in human
astrocytomas
.
Those of
astrocytic
origin are the most widespread of primary brain tumors and account for more then 60% of all CNS neoplasms.
The current state of knowledge on the associations between
tumor
etiology and oxidative stress suggests that environmental factors that cause oxidative stress could also induce and promote cancer, especially in case of hereditary predisposition.
The aim of present study was to investigate by immunohistochemistry the presence of HNE-modified proteins in different types of
astrocytoma
.
Our study comprised 45
astrocytic
tumors.
These tumors were graded in accordance with the WHO classification as diffuse
astrocytomas
(DA),
anaplastic
astrocytomas
(AA) and glioblastomas (GB), while each group comprised 15 tumors.
Slides of paraffin-embedded
tumor
tissue were stained with hematoxylin-eosin or were prepared for immunohistochemistry with monoclonal antibodies to HNE-histidine conjugate.
HNE positivity was proportional with malignancy of
astrocytomas
.
Lowest intensity of HNE immunopositivity was present in
tumor
cells of almost all DA, predominantly around blood vessels.
In
malignant
variants of
astrocytoma
, AA and GB, HNE positivity was moderate to strong, and diffusely distributed in all tumors.
[MeSH-major]
Aldehydes / analysis. Aldehydes / metabolism.
Astrocytoma
/ chemistry. Immunohistochemistry. Proteins / analysis. Proteins / metabolism
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(PMID = 16403961.001).
[ISSN]
0951-6433
[Journal-full-title]
BioFactors (Oxford, England)
[ISO-abbreviation]
Biofactors
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Aldehydes; 0 / Antibodies, Monoclonal; 0 / Proteins; 29343-52-0 / 4-hydroxy-2-nonenal
100.
Shirahata M, Oba S, Iwao-Koizumi K, Saito S, Ueno N, Oda M, Hashimoto N, Ishii S, Takahashi JA, Kato K:
Using gene expression profiling to identify a prognostic molecular spectrum in gliomas.
Cancer Sci
; 2009 Jan;100(1):165-72
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The expression levels of these genes in 152 gliomas (100 glioblastomas, 21
anaplastic
astrocytomas
, 19 diffuse
astrocytomas
, and 12
anaplastic
oligodendrogliomas) were measured using adapter-tagged competitive polymerase chain reaction, a high-throughput reverse transcription-polymerase chain reaction technique.
The gene expression profiling identified clinically informative prognostic molecular features in
astrocytic
and oligodendroglial tumors that were more reliable than the traditional histological classification scheme.
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(PMID = 19038000.001).
[ISSN]
1349-7006
[Journal-full-title]
Cancer science
[ISO-abbreviation]
Cancer Sci.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
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