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1. Li HM, Hsu SS, Wang JS, Weng MJ, Fu JH, Chen CK, Lai PH: Cerebral pilocytic astrocytoma with spontaneous intracranial hemorrhage in adults. J Chin Med Assoc; 2008 Nov;71(11):587-93
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  • [Title] Cerebral pilocytic astrocytoma with spontaneous intracranial hemorrhage in adults.
  • Pilocytic astrocytomas are found predominantly in the pediatric population; reports of these tumors are extremely rare in adults.
  • We report 2 cases of adult pilocytic astrocytoma with intracranial hemorrhage.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a well-enhanced and circumscribed cystic hemorrhagic tumor with mural nodule over the cerebral hemisphere region.
  • The measured relative cerebral blood volume ratios of the mural nodules in these 2 cases were, respectively, 1.34 and 2.81 when compared with normal white matter.
  • After surgical resection, microscopic examination of the lesions showed pilocytic astrocytomas.
  • Since pilocytic astrocytoma and other cystic tumors with mural nodule (such as hemangioblastoma) have similar findings on conventional CT and MRI, PWI is helpful in the differential diagnosis.
  • The literature on hemorrhagic pilocytic astrocytoma is also reviewed.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Cerebral Hemorrhage / etiology

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  • (PMID = 19015059.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
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2. Serafini S, Gururangan S, Friedman A, Haglund M: Identification of distinct and overlapping cortical areas for bilingual naming and reading using cortical stimulation. Case report. J Neurosurg Pediatr; 2008 Mar;1(3):247-54

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  • A bilingual pediatric patient who underwent tumor resection was mapped extraoperatively using cortical stimulation to preserve English and Hebrew languages.
  • Essential cortical sites for primary and secondary languages were compared, photographically recorded, and plotted onto a schematic brain of the patient.

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  • (PMID = 18352772.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS055142; United States / NINDS NIH HHS / NS / R01 NS055142-01A2; United States / NINDS NIH HHS / NS / 5 F32 NS43031-03; United States / NINDS NIH HHS / NS / F32 NS043031; United States / NINDS NIH HHS / NS / F32 NS043031-03; United States / NINDS NIH HHS / NS / NS055142-01A2; United States / NINDS NIH HHS / NS / NS043031-03
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS101380; NLM/ PMC2706700
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3. Ris MD, Beebe DW, Armstrong FD, Fontanesi J, Holmes E, Sanford RA, Wisoff JH, Children's Oncology Group: Cognitive and adaptive outcome in extracerebellar low-grade brain tumors in children: a report from the Children's Oncology Group. J Clin Oncol; 2008 Oct 10;26(29):4765-70
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  • [Title] Cognitive and adaptive outcome in extracerebellar low-grade brain tumors in children: a report from the Children's Oncology Group.
  • PURPOSE: To determine whether pediatric patients treated with surgery only for low-grade tumors in the cerebral hemispheres, supratentorial midline, and exophytic brainstem evidence neurocognitive, academic, adaptive, or emotional/behavioral sequelae.
  • PATIENTS AND METHODS: Ninety-three patients from a natural history study of low-grade astrocytomas were tested an average of 111 days after surgery.
  • CONCLUSION: After surgery for low-grade brain tumors, a significant number of patients was found to function below average, by as much as 55% compared with 25% in the normative population.
  • Moreover, these results suggest greater risk for patients with lesions situated in the left cerebral hemisphere.

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  • (PMID = 18779602.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2653141
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4. Grau E, Balaguer J, Canete A, Martinez F, Orellana C, Oltra S, Hernandez M, Castel V: Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. J Neurooncol; 2009 Jun;93(2):175-82
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  • [Title] Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma.
  • Astrocytic neoplasms are genetically heterogeneous; however a low frequency of genomic changes has been found in juvenile pilocytic astrocytoma (PA) in molecular studies.
  • We studied the subtelomeric regions of 19 primary astrocytoma tumors.
  • These genetic differences would likely contribute to the more favorable behavior of PXAs and may be helpful for molecular differential diagnosis of pediatric cerebral tumors.
  • [MeSH-major] Astrocytoma / genetics. Chromosomal Instability / genetics. Glioma / genetics. Telomere / genetics
  • [MeSH-minor] Brain Neoplasms / genetics. Child. Chromosome Aberrations. DNA, Neoplasm / genetics. DNA, Neoplasm / isolation & purification. Female. Humans. Loss of Heterozygosity. Male. Oligodendroglioma / genetics. Oligodendroglioma / pathology. Sequence Deletion. Spinal Cord Neoplasms / genetics

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  • (PMID = 19099200.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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5. Karami KJ, Poulik J, Rabah R, Krass J, Sood S: Simultaneous choroid plexus carcinoma and pilocytic astrocytoma in a pediatric patient. J Neurosurg Pediatr; 2010 Jan;5(1):104-12
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  • [Title] Simultaneous choroid plexus carcinoma and pilocytic astrocytoma in a pediatric patient.
  • Simultaneous primary brain tumors in pediatric patients without prior chemotherapy or radiotherapy, phacomatosis, or known familial history are a rare occurrence.
  • The authors report the case of a 4-year-old boy with simultaneous choroid plexus carcinoma and pilocytic astrocytoma with features of oligodendroglioma.
  • A multiple staged resection was carried out for each tumor and gross-total resection was achieved.
  • Upon gross inspection intraoperatively as well as postoperative histological analysis, 2 distinct simultaneous tumors were identified: choroid plexus carcinoma and pilocytic astrocytoma.
  • To the authors' knowledge this is the first case report published identifying 2 distinct tumor types with similar radiological appearances in a pediatric patient with no prior history of radiotherapy, chemotherapy, or phacomatosis.
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / surgery. Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Choroid Plexus Neoplasms / diagnosis. Choroid Plexus Neoplasms / surgery. Fourth Ventricle / surgery. Lateral Ventricles / surgery. Magnetic Resonance Imaging. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery. Neuronavigation. Thalamus / surgery. Tomography, X-Ray Computed
  • [MeSH-minor] Child, Preschool. Craniotomy. Humans. Male. Microsurgery. Reoperation


6. Lee CS, Huh JS, Sim KB, Kim YW: Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. Childs Nerv Syst; 2009 Jan;25(1):125-8
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  • [Title] Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma.
  • INTRODUCTION: Massive intracranial hemorrhage is a very rare initial presentation of cerebellar pilocytic astrocytomas.
  • There are no reports in the medical literature on a cerebellar pilocytic astrocytoma presenting with intratumor bleeding (ITB), subarachnoid hemorrhage (SAH), and subdural hematoma (SDH).
  • On incising the dura, we found SDH, the tumor was visible at the cerebellar cortex, and near total removal followed.
  • Microscopic examination of tissue sections revealed a pilocytic astrocytoma.
  • [MeSH-major] Astrocytoma / complications. Cerebellar Neoplasms / complications. Hematoma, Subdural / etiology. Subarachnoid Hemorrhage / etiology
  • [MeSH-minor] Cerebral Hemorrhage / etiology. Cerebral Hemorrhage / surgery. Diagnosis, Differential. Humans. Infant. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18629510.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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7. Khanani MF, Hawkins C, Shroff M, Dirks P, Capra M, Burger PC, Bouffet E: Pilomyxoid astrocytoma in a patient with neurofibromatosis. Pediatr Blood Cancer; 2006 Mar;46(3):377-80
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  • [Title] Pilomyxoid astrocytoma in a patient with neurofibromatosis.
  • Pilomyxoid astrocytoma (PMA), a recently described variant of low-grade astrocytoma is associated with a high rate of recurrence and a propensity for CSF seeding.
  • The first reportable case of PMA occurring in a child with neurofibromatosis type 1 (NF1) is described.
  • Following presentation with obstructive hydrocephalus, the patient underwent a partial resection of a third ventricular tumor.
  • The authors review the literature on PMA and discuss the specific issues associated with this diagnosis in the context of a child with neurofibromatosis.
  • [MeSH-major] Astrocytoma / surgery. Cerebral Ventricle Neoplasms / surgery. Neoplasms, Second Primary / surgery. Neurofibromatosis 1 / surgery
  • [MeSH-minor] Child. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / pathology. Hydrocephalus / surgery

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  • (PMID = 15800886.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Kondageski C, Pierre-Kahn A, Carbonne B, Brunelle F: Association of a fetal quadrigeminal cyst with a possibly congenital thalamic astrocytoma. Childs Nerv Syst; 2005 Apr;21(4):317-21
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  • [Title] Association of a fetal quadrigeminal cyst with a possibly congenital thalamic astrocytoma.
  • CASE REPORT: This article reports on the exceptional association of a fetal quadrigeminal malformative cyst with a possibly congenital pilocytic astrocytoma of the pulvinar.
  • Both the cyst and the tumor required treatment due to their postnatal growth.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Cerebral Aqueduct / pathology. Fetal Diseases / pathology. Pulvinar / pathology

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  • (PMID = 15459783.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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9. Kumar AJ, Leeds NE, Kumar VA, Fuller GN, Lang FF, Milas Z, Weinberg JS, Ater JL, Sawaya R: Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. J Comput Assist Tomogr; 2010 Jul;34(4):601-11
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  • [Title] Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas.
  • OBJECTIVE: The typical magnetic resonance/computed tomographic imaging appearance of pilocytic astrocytoma (PA) is that of a cyst with an intensely enhancing mural nodule.
  • METHODS: One hundred patients referred to the cancer center with brain tumors histologically proven to be PA were retrospectively reviewed (95 by magnetic resonance imaging and 5 by computed tomographic imaging) and analyzed.
  • RESULTS: The patient population includes 76 pediatric patients younger than 18 years and 24 adults ranging from 19 to 45 years old.
  • Tumor locations consisted of the following: optic chiasm (22), lateral ventricle (3), thalamus (12), basal ganglia (1), cerebral hemisphere (10), corpus callosum (2), brain stem (26), fourth ventricle (1), and cerebellum (23).
  • CONCLUSIONS: It is important to recognize the aggressive imaging appearance of PA (grade 1 astrocytoma) because it can be mistaken for high-grade gliomas and may thus lead to inappropriate therapy.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Glioma / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adult. Brain / pathology. Brain / radiography. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed / methods. Young Adult

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  • (PMID = 20657231.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Phi JH, Park SH, Chae JH, Hong KH, Park SS, Kang JH, Jun JK, Cho BK, Wang KC, Kim SK: Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells. Childs Nerv Syst; 2008 Dec;24(12):1499-503
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  • [Title] Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells.
  • OBJECTS: Congenital Subependymal giant cell astrocytoma (SEGA), diagnosed in fetal and neonatal period, is extremely rare.
  • We encountered a patient diagnosed as congenital SEGA and report the surgical outcome along with interesting immuno-phenotypes of giant tumor cells.
  • At postnatal 2 months, gross total resection of the tumor was achieved without complications.
  • The patient had been followed up for 1 year without tumor recurrence.
  • In double immunofluorescence, the prototype cells of SEGA expressed a variety of neural stem cell (nestin and Sox2) and radial glial cell markers (vimentin and brain lipid-binding protein), in addition to glutamate/aspartate transporter and glial fibrillary acidic protein.
  • Pathological findings support the concept that SEGA may originate from aberrant radial glial cells in the developing brain.
  • [MeSH-major] Astrocytoma / surgery. Cerebral Ventricle Neoplasms / surgery. Fetal Diseases / surgery
  • [MeSH-minor] Carrier Proteins / biosynthesis. Female. Fluorescent Antibody Technique / methods. Humans. Infant, Newborn. Intermediate Filament Proteins / biosynthesis. Male. Nerve Tissue Proteins / biosynthesis. Nestin. Pregnancy. Prenatal Diagnosis. SOXB1 Transcription Factors / biosynthesis. Tumor Suppressor Proteins / biosynthesis. Ultrasonography, Prenatal. Vimentin / biosynthesis

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  • (PMID = 18629509.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / FABP7 protein, human; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / Vimentin
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11. Klein O, Grignon Y, Civit T, Pinelli C, Auque J, Marchal JC: [Childhood diencephalic pilocytic astrocytoma. A review of seven observations]. Neurochirurgie; 2006 Feb;52(1):3-14
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  • [Title] [Childhood diencephalic pilocytic astrocytoma. A review of seven observations].
  • [Transliterated title] Les astrocytomes pilocytiques du diencephale de l'enfant. à propos de sept observations.
  • BACKGROUND AND PURPOSE: Pilocytic astrocytoma (PA) is a WHO grade I tumor of the central nervous system mostly arising in children and young adults.
  • MATERIALS AND METHODS: We retrospectively reviewed seven pediatric cases (female: 4, male: 3) of diencephalic PA.
  • Tumor locations were as followed: right thalamus: 2, both thalami: 1, hypothalamus: 3, and right basal ganglia: 1.
  • Three children died, two by tumor progression and one death related to late side-effects of RT.
  • We observed tumor regression in two patients at 1 and 17 years after the beginning of treatment.
  • The tumor can be controlled by a partial surgical removal, and a residual tumor can sometimes decrease in size after surgery.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Hypothalamic Neoplasms / surgery. Thalamic Diseases / surgery
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Dominance, Cerebral / physiology. Female. Follow-Up Studies. Humans. Hypothalamus / pathology. Hypothalamus / surgery. Infant. Magnetic Resonance Imaging. Male. Quality of Life. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Survival Rate. Thalamus / pathology. Thalamus / surgery. Tomography, X-Ray Computed

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  • (PMID = 16609655.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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12. Jea A, Coscarella E, Chintagumpala M, Bhattacharjee M, Whitehead WE, Curry DJ, Luerssen TG: Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. J Neurosurg Pediatr; 2010 Feb;5(2):149-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report.
  • Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type have been published in the adult and pediatric literature.
  • However, the simultaneous occurrence of multiple primary brain tumors with different cell types is rare.
  • Even more rare is the pediatric presentation of multiple primary brain tumors with different cell types.
  • Brain MR imaging demonstrated a heterogeneously enhancing mixed solid/cystic mass of the left cerebellar hemisphere and a larger, midline, more homogeneously enhancing lesion of the superior vermis.
  • Pathological examination revealed the left cerebellar and superior vermian lesions to be a juvenile pilocytic astrocytoma and a medulloblastoma, respectively.
  • To the best of the authors' knowledge, they describe the first known pediatric case in which a medulloblastoma and a juvenile pilocytic astrocytoma presented as synchronous primary brain tumors.
  • They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cerebellar Neoplasms / pathology. Medulloblastoma / pathology
  • [MeSH-minor] Cerebral Cortex / pathology. Cerebral Cortex / surgery. Child. Craniotomy. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Tomography, X-Ray Computed


13. Markia B, Gyorsok Z, Kordás M, Bognár L: [Pediatric intraventricular tumors]. Ideggyogy Sz; 2008 Nov 30;61(11-12):371-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pediatric intraventricular tumors].
  • Pediatric intraventricular tumors present a well circumscribed group from surgical point of view.
  • These tumors growing in the ventricular system cause hydrocephalus in most of the cases, the presenting symptoms are the signs of raised intracranial pressure.
  • The mass lesion may remain silent for a long period, especially in infancy due to compensatory mechanisms, and the tumor might reach extreme size making the surgery a real challenge.
  • In this study we present the retrospective analysis of 55 patient operated for intraventricular tumor in the National Institute of Neurosurgery between 1991 and 2006.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Cerebral Ventricle Neoplasms / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Astrocytoma / diagnosis. Astrocytoma / surgery. Carcinoma / diagnosis. Carcinoma / surgery. Cerebrospinal Fluid Pressure. Child. Child, Preschool. Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Ependymoma / diagnosis. Ependymoma / surgery. Female. Glioma / diagnosis. Glioma / surgery. Humans. Hungary. Hydrocephalus / etiology. Hydrocephalus / physiopathology. Hydrocephalus / surgery. Infant. Magnetic Resonance Imaging. Male. Papilloma / diagnosis. Papilloma / surgery. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 19070311.001).
  • [ISSN] 0019-1442
  • [Journal-full-title] Ideggyógyászati szemle
  • [ISO-abbreviation] Ideggyogy Sz
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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14. De Sio L, Milano GM, Castellano A, Jenkner A, Fidani P, Dominici C, Donfrancesco A: Temozolomide in resistant or relapsed pediatric solid tumors. Pediatr Blood Cancer; 2006 Jul;47(1):30-6
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  • [Title] Temozolomide in resistant or relapsed pediatric solid tumors.
  • PURPOSE: We report the off-label study aimed at investigating the use of temozolomide (TMZ) as single agent in relapsed or resistant pediatric solid tumors.
  • Tumor types were: neuroblastoma (NB; n = 17), medulloblastoma (MB; 8), brain stem glioma (BSG; 8), extraosseous Ewing's sarcoma/peripheral neuroectodermal tumor (EOES; 4), Ewing's sarcoma (ES; 4), anaplastic astrocytoma (AA; 3), rhabdomyosarcoma (RMS; 2), ependymoma (EP; 2), cerebral primitive neuroectodermal tumor (cPNET; 2), hepatocarcinoma (HC; 1), and osteosarcoma (OS; 1).
  • CONCLUSION: Oral TMZ was well tolerated in children with resistant or relapsed solid tumors and showed activity in NB and CNS tumours refractory to standard chemotherapy.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Dose-Response Relationship, Drug. Female. Humans. Male. Survival Analysis

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • [ErratumIn] Pediatr Blood Cancer. 2006 Oct 15;47(5):647-8
  • (PMID = 16047361.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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15. Kim TW, Lee TK, Kim BS, Lee KS, Song IU, Kim JS: Diurnally fluctuating frontal dysequilibrium secondary to a pineal pilocytic astrocytoma: is this symptom associated with a check-valve mechanism in a pineal region tumor? Childs Nerv Syst; 2009 Mar;25(3):367-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diurnally fluctuating frontal dysequilibrium secondary to a pineal pilocytic astrocytoma: is this symptom associated with a check-valve mechanism in a pineal region tumor?
  • CASE REPORT: A 14-year-old boy presented with diurnally fluctuating dysarthria, dysequilibrium of the gait, and retropulsion, probably due to transient obstruction by a tumor at the entrance of the cerebral aqueduct of the pineal region.
  • CONCLUSION: This result suggests that the symptoms of hydrocephalus are possibly associated with a check-valve mechanism of the pineal tumor and may be related to transient compression of the basal ganglia and frontal lobes.
  • [MeSH-major] Astrocytoma / complications. Hydrocephalus / etiology. Hydrocephalus / physiopathology. Pineal Gland / pathology. Pinealoma / complications. Supratentorial Neoplasms / complications

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  • (PMID = 18972117.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Okamoto H, Mineta T, Ueda S, Nakahara Y, Shiraishi T, Tamiya T, Tabuchi K: Detection of JC virus DNA sequences in brain tumors in pediatric patients. J Neurosurg; 2005 Apr;102(3 Suppl):294-8
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  • [Title] Detection of JC virus DNA sequences in brain tumors in pediatric patients.
  • Several recent reports have indicated a possible association between the JC virus and the development of various human brain tumors.
  • The authors examined the presence of JC virus DNA sequences in primary brain tumors in pediatric patients to evaluate the hypothesis that particular brain tumors can arise in the pediatric population as a consequence of infection with the JC virus.
  • METHODS: Genomic DNA sequences were isolated from 62 brain tumors (32 medulloblastomas, 18 ependymomas, five choroid plexus papillomas, and seven pilocytic astrocytomas) and analyzed for the presence of JC virus DNA by Southern blot hybridization and direct sequencing.
  • None of the medulloblastomas or pilocytic astrocytomas contained JC virus DNA.
  • [MeSH-major] Brain Neoplasms / virology. DNA, Viral / genetics. Genome, Viral. JC Virus / genetics. Leukoencephalopathy, Progressive Multifocal / virology
  • [MeSH-minor] Antigens, Viral, Tumor / genetics. Astrocytoma / pathology. Astrocytoma / virology. Base Sequence. Blotting, Southern. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / virology. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / virology. Child. Child, Preschool. Ependymoma / pathology. Ependymoma / virology. Female. Humans. Infant. Male. Medulloblastoma / pathology. Medulloblastoma / virology. Papilloma, Choroid Plexus / pathology. Papilloma, Choroid Plexus / virology. Polymerase Chain Reaction. Supratentorial Neoplasms / pathology. Supratentorial Neoplasms / virology

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  • (PMID = 15881753.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
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17. Gaetz W, Scantlebury N, Widjaja E, Rutka J, Bouffet E, Rockel C, Dockstader C, Mabbott D: Mapping of the cortical spinal tracts using magnetoencephalography and diffusion tensor tractography in pediatric brain tumor patients. Childs Nerv Syst; 2010 Nov;26(11):1639-45
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  • [Title] Mapping of the cortical spinal tracts using magnetoencephalography and diffusion tensor tractography in pediatric brain tumor patients.
  • Prior to resection of a cerebral brain tumor, mapping of the functional and structural anatomy of the adjacent tissue is essential to reduce the risk of damage to descending and ascending pathways.
  • We investigated the effectiveness of concurrent magnetoencephalography (MEG) and diffusion tensor imaging (DTI) tractography to delineate the motor cortex and associated corticospinal tract (CST) in a case series of children with brain tumors seen for pre-surgical evaluation.
  • Our findings suggest that the use of concurrent MEG and DTI may be an effective tool in the pre-surgical evaluation of eloquent cortex and associated white matter tracts in pediatric brain tumor patients.
  • [MeSH-major] Brain Mapping / methods. Brain Neoplasms / diagnosis. Brain Neoplasms / pathology. Brain Neoplasms / physiopathology. Brain Neoplasms / surgery. Diffusion Magnetic Resonance Imaging. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetoencephalography. Motor Cortex / pathology. Motor Cortex / physiopathology. Pyramidal Tracts / pathology. Pyramidal Tracts / physiopathology
  • [MeSH-minor] Adolescent. Astrocytoma / pathology. Astrocytoma / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Child. Dominance, Cerebral / physiology. Electromyography. Female. Glioma / pathology. Glioma / surgery. Humans. Male. Muscle, Skeletal / innervation. Sensitivity and Specificity

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  • (PMID = 20532785.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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18. Jiménez R, Casado-Flores J, Nieto M, García-Teresa MA: Cerebral salt wasting syndrome in children with acute central nervous system injury. Pediatr Neurol; 2006 Oct;35(4):261-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebral salt wasting syndrome in children with acute central nervous system injury.
  • The purpose of this investigation was to describe the causes, clinical pattern, and treatment of cerebral salt wasting syndrome in children with acute central nervous system injury.
  • This retrospective study focused on patients<or=15 years old diagnosed with cerebral salt wasting syndrome, over a period of 7 years, in the pediatric intensive care unit of a tertiary care hospital.
  • Fourteen patients were identified with cerebral salt wasting syndrome, 12 after a neurosurgical procedure (8 brain tumor, 4 hydrocephalus) and 2 after severe brain trauma.
  • In 11 patients the cerebral salt wasting syndrome was diagnosed during the first 48 hours of admission.
  • Prevalence of cerebral salt wasting syndrome in neurosurgical children was 11.3/1000 surgical procedures.
  • The mean duration of cerebral salt wasting syndrome was 6+/-5 days (range 1-9).
  • In conclusion, cerebral salt wasting syndrome can complicate the postoperative course of children with brain injury; it is frequently present after surgery for brain tumors and hydrocephalus and in patients with severe head trauma.
  • [MeSH-major] Astrocytoma / surgery. Brain Injuries / surgery. Brain Neoplasms / surgery. Choroid Plexus Neoplasms / surgery. Craniopharyngioma / surgery. Hydrocephalus / surgery. Hyponatremia / diagnosis. Inappropriate ADH Syndrome / diagnosis. Pituitary Neoplasms / surgery. Postoperative Complications / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Intensive Care Units, Pediatric. Male. Prognosis


19. Dunn IF, Woodworth GF, Siddiqui AH, Smith ER, Vates GE, Day AL, Goumnerova LC: Traumatic pericallosal artery aneurysm: a rare complication of transcallosal surgery. Case report. J Neurosurg; 2007 Feb;106(2 Suppl):153-7
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  • Traumatic intracranial aneurysms are rare in adults but account for up to 33% of all aneurysms encountered in a pediatric population.
  • The most common location of such lesions in children is the pericallosal or adjacent branch of the anterior cerebral artery, where a head impact exerts sudden decelerating shearing forces on the arteries tethered on the brain surface against an immobile falx cerebri, weakening the arterial wall.
  • This 6-year-old boy underwent resection of a hypothalamic pilocytic astrocytoma, which was approached via the transcallosal corridor.
  • A follow-up magnetic resonance image obtained within 1 year of surgery disclosed a small flow void off the right pericallosal artery, which was initially interpreted as residual tumor.
  • [MeSH-major] Astrocytoma / surgery. Corpus Callosum / blood supply. Hypothalamic Neoplasms / surgery. Intracranial Aneurysm / etiology. Intraoperative Complications
  • [MeSH-minor] Angiography, Digital Subtraction. Arteries / injuries. Cerebrovascular Circulation / physiology. Child. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neoplasm, Residual / diagnosis. Temporal Arteries / transplantation

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  • [CommentIn] J Neurosurg Pediatr. 2009 Jun;3(6):542; author reply 542 [19485744.001]
  • (PMID = 17330545.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Dunn IF, Agarwalla PK, Papanastassiou AM, Butler WE, Smith ER: Multiple pilocytic astrocytomas of the cerebellum in a 17-year-old patient with neurofibromatosis type I. Childs Nerv Syst; 2007 Oct;23(10):1191-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple pilocytic astrocytomas of the cerebellum in a 17-year-old patient with neurofibromatosis type I.
  • OBJECTIVE: Approximately 10% of patients with neurofibromatosis I (NFI) patients will have central nervous system (CNS) tumors.
  • The most common of these are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas.
  • While isolated pilocytic astrocytomas in NFI are well described, the appearance of multiple pilocytic astrocytomas in an individual patient is less common.
  • The most frequent combination in NFI patients with more than one pilocytic astrocytoma is optic tract/hypothalamic and brainstem.
  • Other combinations are exceedingly rare; multiple pilocytic astrocytomas have only been reported once in the cerebral hemispheres in a patient with NFI.
  • This report presents the first documented case, to our knowledge, of multiple pilocytic astrocytomas in the cerebellum of a patient with NF1.
  • CONCLUSION: The finding of multiple cerebellar pilocytic astrocytomas in a patient with NF1 is important because it expands the spectrum of presentations for patients with NF1 and also highlights specific diagnostic and therapeutic challenges faced by the treating physicians.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Neurofibromatosis 1 / pathology
  • [MeSH-minor] Adolescent. Cerebral Angiography. Humans. Hydrocephalus / etiology. Hydrocephalus / surgery. Magnetic Resonance Angiography. Male. Tomography, X-Ray Computed

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  • (PMID = 17457593.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Cai R, Di X: Combined intra- and extra-endoscopic techniques for aggressive resection of subependymal giant cell astrocytomas. World Neurosurg; 2010 Jun;73(6):713-8
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  • [Title] Combined intra- and extra-endoscopic techniques for aggressive resection of subependymal giant cell astrocytomas.
  • We report two cases of combined intra-/extra-axial endoscopic procedures--intraventricular solid tumor resection for subependymal giant cell astrocytoma.
  • METHODS: In 2007, two patients with subependymal giant cell astrocytoma with a long history of tuberous sclerosis underwent solely endoscopic, minimally invasive intraventricular tumor resection.
  • Pathologic diagnoses were subependymal giant cell astrocytoma.
  • EMIN is a completive, safe procedure for intraventricular subependymal giant cell astrocytoma.
  • [MeSH-major] Astrocytoma / surgery. Cerebral Ventricle Neoplasms / surgery. Endoscopy / methods. Frontal Lobe / surgery. Lateral Ventricles / surgery. Neurosurgical Procedures / methods

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20934162.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Benesch M, Eder HG, Sovinz P, Raith J, Lackner H, Moser A, Urban C: Residual or recurrent cerebellar low-grade glioma in children after tumor resection: is re-treatment needed? A single center experience from 1983 to 2003. Pediatr Neurosurg; 2006;42(3):159-64
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  • [Title] Residual or recurrent cerebellar low-grade glioma in children after tumor resection: is re-treatment needed? A single center experience from 1983 to 2003.
  • PURPOSE: The aim of this study was to report on children with cerebellar low-grade glioma (LGG), who were found to have progressive or nonprogresssive residual tumors or tumor recurrence after tumor resection.
  • RESULTS: Of 289 patients with CNS tumors referred between 1983 and 2003, 28 (9.7%) (15 male, 13 female; median age at diagnosis: 71 months) had cerebellar LGG (pilocytic astrocytoma grade I: n = 21; fibrillary astrocytoma grade II: n = 5; mixed hamartoma/pilocytic astrocytoma: n = 1; radiographic diagnosis: n = 1).
  • Three patients died, 2 due to symptoms related to brain stem compression/infiltration and 1 patient due to postoperative cerebral edema.
  • CONCLUSIONS: A 'wait and see' strategy is justified in patients with nonprogressive recurrent or residual cerebellar LGG after primary tumor resection.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Postoperative Complications / diagnosis. Postoperative Complications / mortality. Postoperative Complications / surgery. Reoperation. Retrospective Studies. Survival Rate

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  • [Copyright] Copyright 2006 S. Karger AG, Basel
  • (PMID = 16636617.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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23. Rønning C, Sundet K, Due-Tønnessen B, Lundar T, Helseth E: Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood. Pediatr Neurosurg; 2005 Jan-Feb;41(1):15-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood.
  • Traditionally, the cerebral hemispheres have been regarded as the region of the brain responsible for cognitive functions, while the cerebellum has been considered to be primarily involved in motor functions.
  • The aim of this study was to determine the neuropsychological profile of young adults treated for a posterior fossa tumor in childhood and look for possible support for the presence of the so-called 'cerebellar cognitive affective syndrome' in these patients.
  • The astrocytoma group (n = 12) had been treated for a low-grade cerebellar astrocytoma with surgery alone (mean age at surgery was 8.6 years and mean age at neuropsychological testing was 23.5 years).
  • Nonetheless, the astrocytoma group also had impaired scores compared with standard norms on measures of motor speed, attention and executive function.
  • No significant correlation between age at time of treatment and grade of neuropsychological impairment was found in the astrocytoma group, though there was a tendency that young age at time of treatment correlated with better outcome on IQ measures.
  • CONCLUSIONS: Persistent cognitive dysfunction was detected in patients treated for posterior fossa medulloblastoma and cerebellar astrocytoma.
  • The astrocytoma group was treated with surgery alone, indicating that a cerebellar lesion can result in cognitive dysfunction.
  • Follow-up of all patients treated for posterior fossa tumor in childhood should include an extensive neuropsychological testing at regular intervals.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Cerebellum / physiopathology. Cerebellum / surgery. Cognition Disorders / etiology. Medulloblastoma / surgery
  • [MeSH-minor] Adolescent. Attention / physiology. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Infant. Intelligence / physiology. Male. Memory / physiology. Neuropsychological Tests. Postoperative Complications. Psychomotor Performance / physiology

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15886508.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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24. Schiffman JD, Chun N, Fisher PG, Dahl GV, Ford JM, Eggerding FA: Identification of a novel p53 in-frame deletion in a Li-Fraumeni-like family. Pediatr Blood Cancer; 2008 Apr;50(4):914-6
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  • We describe a 2-year-old female with a completely resected cerebral pilocytic astrocytoma who subsequently developed B-progenitor acute lymphoblastic leukemia (ALL).
  • [MeSH-major] Li-Fraumeni Syndrome / genetics. Sequence Deletion / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Astrocytoma / genetics. Base Sequence. Brain Neoplasms / genetics. Child, Preschool. DNA Mutational Analysis. Female. Germ-Line Mutation. Humans. Male. Middle Aged. Pedigree. Polymerase Chain Reaction. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 17554785.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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25. Tirakotai W, Hellwig D, Bertalanffy H, Riegel T: The role of neuroendoscopy in the management of solid or solid-cystic intra- and periventricular tumours. Childs Nerv Syst; 2007 Jun;23(6):653-8
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  • The majority of pathological examinations revealed astrocytoma (23), craniopharygioma (7) and metastasis (2).
  • [MeSH-major] Cerebral Ventricle Neoplasms / complications. Hydrocephalus / surgery. Neuroendoscopy / methods. Third Ventricle / surgery. Ventriculostomy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / complications. Astrocytoma / surgery. Child. Craniopharyngioma / complications. Craniopharyngioma / surgery. Female. Humans. Male. Middle Aged

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  • (PMID = 17387489.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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26. Hsu TR, Wong TT, Chang FC, Ho DM, Tang RB, Thien PF, Chang KP: Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children. Childs Nerv Syst; 2008 Dec;24(12):1457-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Though the pathology of optic pathway tumor is mostly pilocytic astrocytoma, the benign tumor behaves like malignant tumor because total resection is not feasible.
  • We evaluate the responsiveness of optic pathway tumor to cisplatin-based chemotherapy.
  • Brain MRI was performed every 3 months to evaluate the objective response to chemotherapy.
  • The pathology showed pilocytic astrocytomas in 11 patients, astrocytoma in one patient, and anaplastic astrocytomas in two patients.
  • The toxicity of the cisplatin-based chemotherapy showed mild bone marrow suppression in 13 patients (81.3%), infection in nine patients (56.3%), gastrointestinal discomfort in seven patients (43.8%), renal insufficiency in two patient (12.5%), cerebral salt wasting syndrome with hyponatremia in one patient (6.25%) and high pitch hearing loss in two patients (12.5%).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / drug therapy. Optic Nerve Neoplasms / drug therapy
  • [MeSH-minor] Bone Marrow Diseases / chemically induced. Child. Child, Preschool. Cisplatin / administration & dosage. Cisplatin / adverse effects. Disease-Free Survival. Drug Administration Schedule. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Gastrointestinal Diseases / chemically induced. Humans. Infection / chemically induced. Magnetic Resonance Imaging. Male. Treatment Outcome. Vinblastine / administration & dosage. Vinblastine / adverse effects

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  • (PMID = 18769928.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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27. Nilsson D, Rutka JT, Snead OC 3rd, Raybaud CR, Widjaja E: Preserved structural integrity of white matter adjacent to low-grade tumors. Childs Nerv Syst; 2008 Mar;24(3):313-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND PURPOSE: Brain tumors may dislocate, infiltrate, or disrupt the adjacent fiber tracts.
  • We examined (1) microstructural changes of white matter (WM) adjacent to supratentorial low grade tumors in children and (2) WM tracts of the affected hemisphere using diffusion tensor imaging (DTI).
  • Regions of interest were placed in the tumor, in WM adjacent to tumor, and on the normal contralateral side.
  • RESULTS: There were no significant differences in FA, trace, and eigenvalues between WM adjacent to tumor and the contralateral side.
  • [MeSH-major] Astrocytoma / pathology. Brain Mapping. Ganglioglioma / pathology. Nerve Fibers, Myelinated / pathology. Neural Pathways / pathology. Supratentorial Neoplasms / pathology
  • [MeSH-minor] Adolescent. Anisotropy. Cerebral Cortex / pathology. Child. Child, Preschool. Diffusion Magnetic Resonance Imaging. Female. Follow-Up Studies. Functional Laterality. Humans. Male

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  • (PMID = 17960393.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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28. Miyata S, Gomi A, Yamaguchi T, Tanaka Y, Watanabe E, Tanaka A: Case of unclassified, radiosensitive, malignant neuroepithelial tumor in the temporal lobe of a child. Brain Tumor Pathol; 2010 Apr;27(1):45-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case of unclassified, radiosensitive, malignant neuroepithelial tumor in the temporal lobe of a child.
  • A case of unclassified, pediatric cerebral neuroepithelial tumor in a 10-year-old girl that showed remarkable radiosensitivity is reported.
  • MRI revealed a brain tumor of mixed intensity with heterogeneous enhancement in the medial temporal lobe, extending to the basal ganglia.
  • The tumor was partially removed.
  • On pathology, the main part of the tumor showed immature features: the tumor cells had a chromatin-rich large nucleus and less cytoplasm, and mitoses and fragmentation of the nuclei were frequent.
  • On immunohistochemistry, the tumor cells were negative for glial fibrillary acidic protein (GFAP) and synaptophysin and positive for Olig2.
  • The part invading into the surrounding brain showed similarities in form to a highly anaplastic astrocytoma.
  • The infiltrating tumor cells were positive for GFAP and less positive for Olig2.
  • After 40 Gy radiation, the residual tumor was markedly reduced.
  • Neuroepithelial tumors rarely show such high radiosensitivity, and the reason for the radiosensitivity in the present case may have been the immaturity of the tumor cells.
  • [MeSH-major] Brain Neoplasms / therapy. Neoplasms, Neuroepithelial / therapy. Radiation Tolerance. Temporal Lobe
  • [MeSH-minor] Astrocytoma. Basic Helix-Loop-Helix Transcription Factors / analysis. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Ki-67 Antigen / analysis. Neoplasm, Residual. Nerve Tissue Proteins / analysis. Radiotherapy Dosage. Synaptophysin / analysis. Treatment Outcome

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  • (PMID = 20425048.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Nerve Tissue Proteins; 0 / OLIG2 protein, human; 0 / Synaptophysin
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29. Pinto Gama HP, da Rocha AJ, Braga FT, da Silva CJ, Maia AC Jr, de Campos Meirelles RG, Mendonça do Rego JI, Lederman HM: Comparative analysis of MR sequences to detect structural brain lesions in tuberous sclerosis. Pediatr Radiol; 2006 Feb;36(2):119-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of MR sequences to detect structural brain lesions in tuberous sclerosis.
  • MR is the imaging method of choice to demonstrate structural brain lesions in TS.
  • OBJECTIVE: To compare MR sequences and determine which is most useful for the demonstration of each type of brain lesion in TS patients.
  • MATERIALS AND METHODS: We reviewed MR scans of 18 TS patients for the presence of cortical tubers, white matter lesions (radial bands), subependymal nodules, and subependymal giant cell astrocytoma (SGCA) on the following sequences:.
  • CONCLUSION: We demonstrated the importance of appropriate MRI sequences for diagnosis of the most frequent brain lesions in TS.
  • [MeSH-major] Brain / pathology. Cerebral Cortex / pathology. Magnetic Resonance Imaging. Tuberous Sclerosis / diagnosis
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Male. Reproducibility of Results. Retrospective Studies

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  • (PMID = 16283285.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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30. Paixão Becker A, de Oliveira RS, Saggioro FP, Neder L, Chimelli LM, Machado HR: In pursuit of prognostic factors in children with pilocytic astrocytomas. Childs Nerv Syst; 2010 Jan;26(1):19-28
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In pursuit of prognostic factors in children with pilocytic astrocytomas.
  • OBJECTIVE: This study described a 23-year experience in the treatment of children with pilocytic astrocytomas (piloA) with the aim of identifying putative clinical, histopathological, and/or immunohistochemical features that could be related to the outcome of these patients.
  • The most common site of tumor formation was the cerebellum (17), followed by brainstem (4), optic chiasmatic hypothalamic region (4), cerebral hemisphere (3), cervical spinal cord (2), and optic nerve (1).
  • Gross total resection (GTR) was achieved in 23 (74.1%), mainly in those with tumors located in the cerebellum and cerebral hemispheres (P = 0.02).
  • In all cases, Gal-3 expression in tumor cells was observed with variable staining pattern.
  • Tumor recurrence or progression of the residual lesion should be strictly observed.
  • In some aspects, childhood piloA remains an enigmatic tumor.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Brain / pathology. Brain / radiography. Brain / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Galectin 3 / metabolism. Humans. Infant. Ki-67 Antigen / metabolism. Male. Prognosis. Spinal Cord / pathology. Spinal Cord / radiography. Spinal Cord / surgery. Treatment Outcome

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  • (PMID = 19823847.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Ki-67 Antigen
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31. Roopesh Kumar SV, Mohanty A, Santosh V, Satish S, Devi BI, Praharaj SS, Kolluri SV: Endoscopic options in management of posterior third ventricular tumors. Childs Nerv Syst; 2007 Oct;23(10):1135-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A positive biopsy was obtained in all the patients (pinealocytoma 4, pinealoblastoma 10, embryonal cell carcinoma 1, germinoma 2, oligodendroglioma 1, astrocytoma 2, tuberculoma 4).
  • One patient with a tumor bed hematoma required clot evacuation.
  • Two patients died, one during hospital stay with a tumor bed hematoma and another at 6 months follow-up due to extensive leptomeningeal spread.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Endoscopy. Neurosurgical Procedures. Third Ventricle / pathology
  • [MeSH-minor] Adolescent. Adult. Biopsy. Brain / pathology. Child. Craniotomy. Decompression, Surgical. Female. Humans. Hydrocephalus / diagnosis. Hydrocephalus / etiology. Hydrocephalus / surgery. Infant. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17541605.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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