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1. Hoyama E, Cruz AA, Colli BO, Matos JR, Chahud F: Isolated low grade pilocytic astrocytoma of the optic nerve in the elderly: case report. Arq Bras Oftalmol; 2008 Jan-Feb;71(1):97-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated low grade pilocytic astrocytoma of the optic nerve in the elderly: case report.
  • A 68-year-old man presented with a history of a right optic glioma.
  • Eighteen months ago he underwent a lateral orbitotomy at another institution for removal of an optic nerve mass.
  • At that time histology revealed that the tumor was an optic nerve glioma with a pilocytic pattern.
  • Magnetic resonance imaging of the orbit showed that his right orbit was almost completely filled with a mass which extended through the optic canal to the chiasma.
  • Histology proved that the neoplasm was a low grade pilocytic astrocytoma of the optic nerve.
  • [MeSH-major] Astrocytoma / diagnosis. Optic Nerve Neoplasms / diagnosis

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  • (PMID = 18408847.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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2. Miyamoto J, Tatsuzawa K, Owada K, Kawabe T, Sasajima H, Mineura K: Usefulness and limitations of fluorine-18-fluorodeoxyglucose positron emission tomography for the detection of malignancy of orbital tumors. Neurol Med Chir (Tokyo); 2008;48(11):495-9; discussion 499

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological examination identified 7 lesions as malignant: anaplastic astrocytoma of the optic nerve in 1 patient, which recurred as glioblastoma of the optic nerve, malignant lymphoma of mucosa-associated lymphoid tissue type in 1 patient, malignant melanoma in 1 patient, adenoid cystic carcinoma in 2 patients, and adenocarcinoma (unknown origin) in 1 patient.
  • [MeSH-major] Optic Nerve Neoplasms / radionuclide imaging. Orbital Neoplasms / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adolescent. Adult. Aged. Astrocytoma / radionuclide imaging. Carcinoma, Adenoid Cystic / radionuclide imaging. Diagnosis, Differential. Female. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Glioblastoma / radionuclide imaging. Hemangioma, Cavernous, Central Nervous System / radionuclide imaging. Humans. Lymphoma, B-Cell, Marginal Zone / radionuclide imaging. Male. Melanoma / radionuclide imaging. Middle Aged. Neurilemmoma / radionuclide imaging. Orbital Pseudotumor / radionuclide imaging. Radiopharmaceuticals. Young Adult

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  • (PMID = 19029776.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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3. Aguilar Moliner I, Costa Orvay JA, Juma K, Costa Clara JM, Cruz Martínez O, Pou Fernández J: [Optic pathway astrocytoma: an unusual cause of failure to thrive in infants]. An Pediatr (Barc); 2007 Jun;66(6):622-4
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  • [Title] [Optic pathway astrocytoma: an unusual cause of failure to thrive in infants].
  • We report a case of low-grade astrocytoma of the optic pathway in a 2-month-old child whose main symptoms at diagnosis were failure to thrive and anorexia.
  • [MeSH-major] Brain Neoplasms / diagnosis. Failure to Thrive / etiology. Optic Nerve Glioma / diagnosis

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  • (PMID = 17583627.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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4. Jeon YK, Cheon JE, Kim SK, Wang KC, Cho BK, Park SH: Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol; 2008 Nov;21(11):1345-56
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  • [Title] Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization.
  • Pilomyxoid astrocytoma is a recently identified variant of pilocytic astrocytoma.
  • In one patient, a tumor that recurred after initial surgery had changed from pure-form pilomyxoid astrocytoma to the mixed form.
  • Next, we compared the comprehensive genome copy number changes in the pilomyxoid astrocytoma (n=4) with those in pilocytic astrocytoma (n=6) cases by array-based comparative genomic hybridization.
  • The number of lost clones was larger in pilomyxoid astrocytoma than in pilocytic astrocytoma.
  • Clones located in chromosome 8q24.3 were frequently gained in pilocytic astrocytoma (four of six) and in pilomyxoid astrocytoma (one of four).
  • The frequency of copy number changes was significantly different between pilomyxoid astrocytoma and pilocytic astrocytoma in 47 (3.6%) clones, 20 of them having been located in 2p, 10 in 2q, and 11 in 3q.
  • An unsupervised hierarchical clustering analysis classified the cases into three clusters: one pilomyxoid astrocytoma patient into one cluster, two pilomyxoid astrocytoma patients into another cluster, and six pilocytic astrocytoma patients and one pilomyxoid astrocytoma patient into the third cluster.
  • In conclusion, the presence of mixed-form pilomyxoid astrocytoma, the acquisition of pilocytic astrocytoma features in a recurrent tumor in pure-form pilomyxoid astrocytoma, and the above results of the genome-wide gene copy number analysis suggest that pilomyxoid astrocytoma might be a pathologically and genetically related, aggressive variant of pilocytic astrocytoma with partially different genetic alterations.
  • [MeSH-major] Astrocytoma / pathology. Comparative Genomic Hybridization / methods. Gene Dosage. Hypothalamic Neoplasms / pathology. Hypothalamus, Anterior / pathology. Optic Nerve Neoplasms / pathology

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  • (PMID = 18622384.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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5. Viennet A, Nezzar H, Bonnin N, Sinardet D, Campagne D, Demeocq F, Kemeny JL, Bacin F: [An optic nerve glioma in a 4-month-old child]. J Fr Ophtalmol; 2008 Jun;31(6 Pt 1):618-21
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  • [Title] [An optic nerve glioma in a 4-month-old child].
  • The optic nerve glioma is a relatively rare pathology in children and only a few cases have been described in infants.
  • [MeSH-major] Astrocytoma / diagnosis. Optic Nerve Glioma / diagnosis

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  • (PMID = 18772815.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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6. Zhu Y, Harada T, Liu L, Lush ME, Guignard F, Harada C, Burns DK, Bajenaru ML, Gutmann DH, Parada LF: Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development; 2005 Dec;132(24):5577-88
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  • [Title] Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.
  • Children with this disease suffer a high incidence of optic gliomas, a benign but potentially debilitating tumor of the optic nerve; and an increased incidence of malignant astrocytoma, reactive astrogliosis and intellectual deficits.
  • Primary among these is a developmental defect resulting in global reactive astrogliosis in the adult brain and increased proliferation of glial progenitor cells leading to enlarged optic nerves.
  • As a consequence, all of the mutant optic nerves develop hyperplastic lesions, some of which progress to optic pathway gliomas.
  • These data point to hyperproliferative glial progenitors as the source of the optic tumors and provide a genetic model for NF1-associated astrogliosis and optic glioma.

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  • (PMID = 16314489.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS052606-01; United States / NINDS NIH HHS / NS / P50 NS052606; United States / NINDS NIH HHS / NS / P50 NS052606-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neurofibromin 1
  • [Other-IDs] NLM/ NIHMS149022; NLM/ PMC2760350
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7. Romano LM, Gaspari M, Guagnini M: [Bilateral malignant astrocytoma of the optic nerve in the adult]. Neurologia; 2007 Jul-Aug;22(6):389-90
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  • [Title] [Bilateral malignant astrocytoma of the optic nerve in the adult].
  • [MeSH-major] Magnetic Resonance Imaging. Optic Nerve Glioma / radiography

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  • (PMID = 17610167.001).
  • [ISSN] 0213-4853
  • [Journal-full-title] Neurología (Barcelona, Spain)
  • [ISO-abbreviation] Neurologia
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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8. Rodríguez-Francia P, Sánchez-Tocino H, García-Cantera M, Martín-Castillo J: [Optic nerve pilocytic astrocytoma with retinal involvement]. Arch Soc Esp Oftalmol; 2005 Dec;80(12):733-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Optic nerve pilocytic astrocytoma with retinal involvement].
  • INTRODUCTION: This is an atypical case of a pilocytic astrocytoma that involved the optic nerve (ON) and the retina.
  • The histopathological study after enucleation was pilocytic astrocytoma.
  • [MeSH-major] Optic Nerve Glioma / secondary. Optic Nerve Neoplasms / pathology. Retinal Neoplasms / secondary

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  • (PMID = 16372218.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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9. Tibbetts KM, Emnett RJ, Gao F, Perry A, Gutmann DH, Leonard JR: Histopathologic predictors of pilocytic astrocytoma event-free survival. Acta Neuropathol; 2009 Jun;117(6):657-65
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  • [Title] Histopathologic predictors of pilocytic astrocytoma event-free survival.
  • Pilocytic astrocytoma (PA) is the most common pediatric brain tumor.
  • Most arise in the cerebellum, but they also can develop in the brainstem and optic nerve, where gross total resection (GTR) is not possible.
  • Similar to previous reports, we also found that PAs involving the optic pathway were associated with worse EFS compared with those arising in other locations.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology


10. Tumialán LM, Dhall SS, Biousse V, Newman NJ: Optic nerve glioma and optic neuritis mimicking one another: case report. Neurosurgery; 2005 Jul;57(1):E190; discussion E190
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  • [Title] Optic nerve glioma and optic neuritis mimicking one another: case report.
  • OBJECTIVE AND IMPORTANCE: The clinical and radiographic presentations of optic nerve gliomas and optic neuritis are for the most part distinct and their diagnoses straightforward.
  • We present two cases illustrating the occasional difficulty one can encounter in distinguishing neoplastic from inflammatory optic neuropathies.
  • INTERVENTION: Patient 1 was initially diagnosed with idiopathic retrobulbar optic neuritis.
  • Interval increase of the optic nerve on magnetic resonance imaging prompted a biopsy of the optic nerve, which revealed a pilocytic astrocytoma.
  • Patient 2 was found to have left optic nerve enhancement most consistent with an optic nerve glioma.
  • CONCLUSION: Differentiating between optic nerve neoplasm and inflammation may be difficult.
  • On occasion, the classic clinical finding of pain with eye movement and the radiographic finding of enlargement and enhancement of the optic nerve may be misleading.
  • Open biopsy of the optic nerve is indicated only after a completely negative metabolic, infectious, and inflammatory workup; interval increase of the optic nerve on magnetic resonance imaging; and failure of the patient to recover vision.
  • [MeSH-major] Optic Nerve Glioma / diagnosis. Optic Nerve Glioma / physiopathology. Optic Neuritis / diagnosis. Optic Neuritis / physiopathology

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  • (PMID = 15987555.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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11. Gündüz K, Catak E, Erden E: Optic nerve biopsy via a medial transconjunctival orbitotomy approach in the diagnosis of optic nerve and sheath tumors. Orbit; 2010 Aug;29(4):190-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optic nerve biopsy via a medial transconjunctival orbitotomy approach in the diagnosis of optic nerve and sheath tumors.
  • PURPOSE: To evaluate the role of optic nerve biopsy in the diagnosis and management of optic nerve and sheath tumors.
  • METHODS: Seven patients with progressive optic nerve and sheath tumors for whom treatment was deemed necessary were included in this study.
  • Optic nerve biopsy via a medial transconjunctival orbitotomy approach was performed in all patients RESULTS: There were no complications related to the surgical procedure.
  • Histopathological examination revealed that five patients had juvenile pilocytic astrocytoma (JPA) and two patients had optic nerve sheath meningioma (ONSM).
  • CONCLUSIONS: Many other benign and malignant optic nerve and sheath tumors have imaging features similar to those seen in JPA and ONSM.
  • Optic nerve biopsy via a transconjunctival orbitotomy procedure in seven patients yielded histopathologic confirmation of the existing pathology and was not associated with any complications in this series.
  • [MeSH-major] Biopsy, Needle / methods. Nerve Sheath Neoplasms / pathology. Optic Nerve / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Adolescent. Astrocytoma / pathology. Astrocytoma / surgery. Child. Child, Preschool. Conjunctiva / surgery. Female. Follow-Up Studies. Humans. Male. Meningioma / pathology. Meningioma / surgery. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Ophthalmologic Surgical Procedures / methods. Orbit / surgery. Sampling Studies

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  • (PMID = 20812834.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Chen L, Wang Y, Zhu XZ: [Pilomyxoid astrocytoma: a clinicopathologic study of three cases]. Zhonghua Bing Li Xue Za Zhi; 2006 Dec;35(12):727-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pilomyxoid astrocytoma: a clinicopathologic study of three cases].
  • OBJECTIVE: To study the clinicopathologic features of pilomyxoid astrocytoma (PmA).
  • Two cases were located in the third ventricle, while the remaining case was located at the optic pathway.
  • The biphasic pattern noted in a classic pilocytic astrocytoma was not found in PmA.
  • CONCLUSIONS: PmA is a distinctive variant of pilocytic astrocytoma with subtle histologic differences.
  • Compared with conventional pilocytic astrocytoma, PmA behaves more aggressively.
  • [MeSH-major] Astrocytoma / pathology. Cerebral Ventricle Neoplasms / pathology. Optic Nerve Glioma / pathology. Third Ventricle / pathology

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  • (PMID = 17374256.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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13. Yap L, Crooks D, Warnke P: Low grade astrocytoma of the pituitary stalk. Acta Neurochir (Wien); 2007 Mar;149(3):307-11; discussion 311-2
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  • [Title] Low grade astrocytoma of the pituitary stalk.
  • A case of low grade astrocytoma (WHO grade II) localised in the pituitary stalk is reported in a 46 year old female who presented with central diabetes insipidus.
  • [MeSH-major] Astrocytoma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Humans. Hypophysectomy. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Optic Nerve / pathology. Pituitary Gland / pathology. Pituitary Irradiation. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 17242848.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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14. Tchoghandjian A, Fernandez C, Colin C, El Ayachi I, Voutsinos-Porche B, Fina F, Scavarda D, Piercecchi-Marti MD, Intagliata D, Ouafik L, Fraslon-Vanhulle C, Figarella-Branger D: Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature. Brain; 2009 Jun;132(Pt 6):1523-35
Genetic Alliance. consumer health - Pilocytic astrocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature.
  • These tumours affect preferentially the cerebellum (benign clinical course) and the optic pathway, especially the hypothalamo-chiasmatic region (poor prognosis).
  • [MeSH-major] Astrocytoma / diagnosis. Optic Nerve Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Astrocytes / metabolism. Cell Proliferation. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / genetics. Cerebellar Neoplasms / pathology. Child. Child, Preschool. DNA, Neoplasm / genetics. Diagnosis, Differential. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic. Humans. Hypothalamus / metabolism. Infant. Middle Aged. Neoplastic Stem Cells / pathology. Neuroglia / pathology. Oligonucleotide Array Sequence Analysis / methods. Optic Chiasm / cytology. Optic Chiasm / embryology. Optic Chiasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Up-Regulation. Vimentin / metabolism. Young Adult

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  • (PMID = 19336457.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Vimentin
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15. Josan VA, Timms CD, Rickert C, Wallace D: Cerebellar astrocytoma presenting with precocious puberty in a girl. Case report. J Neurosurg; 2007 Jul;107(1 Suppl):66-8
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  • [Title] Cerebellar astrocytoma presenting with precocious puberty in a girl. Case report.
  • The common lesions are hypothalamic hamartomas, optic nerve gliomas, suprasellar arachnoid cysts, hydrocephalus, germinomas, and other sellar/suprasellar lesions.
  • Central precocious puberty secondary to a cerebellar astrocytoma is extremely rare.
  • [MeSH-major] Astrocytoma / diagnosis. Cerebellar Neoplasms / diagnosis. Puberty, Precocious / etiology

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  • (PMID = 17644924.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 4TI98Z838E / Estradiol
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16. Bosnjak R, Benedicic M: Direct epidural electrical stimulation of the optic nerve: a new method for intraoperative assessment of function. J Neurosurg; 2008 Oct;109(4):647-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Direct epidural electrical stimulation of the optic nerve: a new method for intraoperative assessment of function.
  • Intraoperative visual system monitoring of lesions with a close relationship to the optic apparatus by using light flashes reportedly is difficult to perform, and the results are too unreliable to interpret.
  • The authors used direct epidural electrical stimulation of the optic nerve (ON) during surgery instead of light flashes.
  • In 3 patients-1 each harboring a planum sphenoidale meningioma, a tuberculum sellae meningioma, and an intraorbital ON sheath meningioma-2 stimulating needle electrodes were placed on each side of the ON just anterior to the optic canal, before unroofing the optic canal and an extradural anterior clinoidectomy.
  • In the fourth patient, who harbored a frontotemporal astrocytoma, stimulation was applied at the exit of the ON from the canal.
  • In the patient with a symptomatic tuberculum sellae meningioma, the decompressive effect of opening the optic canal and the impact of manipulation during piecemeal tumor removal were detected by the eVEPs.
  • Epidural electrical stimulation of the ON is a safe means of providing a stable signal and real-time information on nerve conduction during surgery.
  • [MeSH-major] Electric Stimulation / methods. Evoked Potentials, Visual. Meningeal Neoplasms / surgery. Meningioma / surgery. Monitoring, Intraoperative / methods. Optic Nerve / physiology
  • [MeSH-minor] Aged. Astrocytoma / surgery. Brain Neoplasms / surgery. Electrodes. Feasibility Studies. Female. Humans. Male. Middle Aged. Optic Nerve Neoplasms / surgery. Pilot Projects. Postoperative Complications. Reproducibility of Results. Sella Turcica

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  • (PMID = 18826351.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Technical Report; Validation Studies
  • [Publication-country] United States
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17. Bohner G, Masuhr F, Distl R, Katchanov J, Klingebiel R, Zschenderlein R, von Deimling A, van Landeghem FK: Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. Acta Neuropathol; 2005 Sep;110(3):306-11
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  • [Title] Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature.
  • We describe a 25-year-old male patient with primary diffuse leptomeningeal gliomatosis (PDLG) presenting with gait ataxia, positive Lhermitte's sign, double vision, and right abducens nerve palsy.
  • Spinal leptomeningeal biopsy revealed a pilocytic astrocytoma WHO grade I.
  • A thorough autopsy showed no evidence for primary neoplasms in brain, spine and optic nerve.
  • Sequence analysis of tumor protein 53 gene (TP53) revealed a missense mutation in exon 5, and expression of phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) protein was not detected, which may have contributed to astrocytoma development.
  • To our knowledge, this is the first definitive case of pilocytic astrocytoma presenting as PDLG.
  • [MeSH-major] Astrocytoma / pathology. Meningeal Neoplasms / pathology. Meninges / pathology. Neoplasms, Neuroepithelial / pathology. Neoplasms, Unknown Primary / pathology. Subarachnoid Space / pathology

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  • (PMID = 16003541.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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18. Sparagana SP, Wilkes DC, Thompson CE, Bowers DC: Optic nerve tumor in tuberous sclerosis complex is not responsive to sirolimus. Pediatr Neurol; 2010 Jun;42(6):443-6
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  • [Title] Optic nerve tumor in tuberous sclerosis complex is not responsive to sirolimus.
  • A 12-year-old girl with clinically established tuberous sclerosis complex, and without signs of neurofibromatosis type 1, developed a right retro-ocular optic nerve tumor.
  • After rapid growth for 1 year after its discovery, the optic nerve tumor demonstrated modest progression.
  • Although her left ventricular subependymal giant cell tumor demonstrated a 49% reduction in volume, the optic nerve tumor did not respond, and even underwent slight (6%) growth during the 16-month treatment.
  • The quality of this child's vision has remained normal in both eyes, and she is otherwise asymptomatic with regard to the optic nerve tumor.
  • [MeSH-major] Astrocytoma / drug therapy. Brain Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy. Optic Nerve Neoplasms / drug therapy. Sirolimus / therapeutic use. Tuberous Sclerosis / complications

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20472200.001).
  • [ISSN] 1873-5150
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; W36ZG6FT64 / Sirolimus
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19. Tong Z, Wanibuchi M, Uede T, Tanabe S, Hashi K: Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report. Neurosurgery; 2006 Apr;58(4):E792; discussion E792
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  • [Title] Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report.
  • OBJECTIVE AND IMPORTANCE: Intracranial giant optic nerve gliomas, usually presumed as optic chiasmatic gliomas, are much less common.
  • The architectural tumor form of optic nerve glioma without neurofibromatosis type 1 is usually the expansile-intraneural pattern.
  • The exophytic optic nerve gliomas without neurofibromatosis type 1 are relatively uncommon.
  • Surgical decompression for intracranial optic gliomas frequently leads to clinical improvement, but obvious improvement of vision is rare.
  • We report a case that demonstrated significant recovery of visual function after removal of the intracranial giant optic nerve glioma, revealing exophytic growth.
  • On heavily T2-reversed MRIs, it was obvious that the intracranial portion of right optic nerve was enlarged, and optic tracts were shifted to the left by the tumor.
  • INTERVENTION: A right frontotemporal craniotomy for decompression of the optic apparatus was performed.
  • After the majority of the tumor was resected, it became clear that the tumor originated in the right optic nerve.
  • The tumor exophytically grew and dislocated the optic chiasma and optic tracts.
  • The histological diagnosis was pilocytic astrocytoma.
  • CONCLUSION: Giant exophytic gliomas without neurofibromatosis type 1 may arise from the intracranial portion of an isolated optic nerve.
  • Direct visualization of optic component by heavily T2-reversed MRI could more precisely delineate the relationship of the intracranial optic nerve glioma to the optic apparatus.
  • Surgery may be indicated in giant exophytic intracranial optic nerve gliomas and preoperative postulated optic chiasmatic gliomas.
  • [MeSH-major] Cell Proliferation. Optic Nerve Glioma / pathology. Optic Nerve Glioma / surgery. Vision Disorders / pathology. Vision Disorders / surgery

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  • (PMID = 16575300.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Shah M, Park HJ, Gohari AR, Bhatti MT: Loss of myelinated retinal nerve fibers from chronic papilledema. J Neuroophthalmol; 2008 Sep;28(3):219-21
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  • [Title] Loss of myelinated retinal nerve fibers from chronic papilledema.
  • An intracranial pilocytic astrocytoma was diagnosed in a 13-year-old boy after he presented with headaches and visual disturbances.
  • The initial ophthalmoscopic examination revealed papilledema bilaterally and myelinated retinal nerve fibers (MRNFs) in the left eye.
  • The disappearance of MRNFs has been described in the presence of ischemia, compression, glaucoma, and demyelinating disease of the optic nerve.
  • This patient demonstrates that loss of myelinated nerves fibers may also occur with the optic atrophy that may follow chronic papilledema.
  • [MeSH-major] Astrocytoma / complications. Hypothalamic Neoplasms / complications. Nerve Fibers, Myelinated / pathology. Optic Atrophy / etiology. Papilledema / complications
  • [MeSH-minor] Adolescent. Chronic Disease. Disease Progression. Humans. Male. Optic Disk / pathology. Optic Disk / physiopathology. Optic Nerve / pathology. Optic Nerve / physiopathology. Retinal Ganglion Cells / pathology. Vision, Low / etiology. Vision, Low / pathology. Vision, Low / physiopathology

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  • (PMID = 18769289.001).
  • [ISSN] 1536-5166
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Liang CL, Lu K, Liliang PC, Chen HJ: Gamma Knife surgery for optic glioma. Report of 2 cases. J Neurosurg; 2010 Dec;113 Suppl:44-7
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  • [Title] Gamma Knife surgery for optic glioma. Report of 2 cases.
  • Optic pathway/hypothalamic gliomas represent approximately 2%-5% of brain tumors in children.
  • In this article the authors discuss the results of Gamma Knife surgery (GKS) for optic gliomas in 2 children.
  • Two pediatric patients, a boy and a girl, underwent GKS for optic gliomas at our hospital between March 2005 and August 2005.
  • The histological diagnosis was confirmed to be pilocytic astrocytoma in both cases.
  • The tumor involved the optic chiasm in 1 patient and the right optic nerve in the other patient.
  • Treatments were planned with the prescription of 11 Gy to the 50% isodose line for the optic chiasm glioma and 15 Gy to the 50% isodose line for the optic nerve glioma.
  • Gamma Knife surgery permits treatment of optic glioma with good tumor control and no clinically relevant morbidity.
  • With the ability to deliver a high dose to the tumor while sparing normal brain tissue, especially the optic nerve, optic chiasm, and pituitary gland, GKS should be the choice of treatment for optic gliomas.
  • [MeSH-major] Astrocytoma / surgery. Optic Nerve / surgery. Optic Nerve Glioma / surgery. Radiosurgery / instrumentation

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  • (PMID = 21121786.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Bajenaru ML, Garbow JR, Perry A, Hernandez MR, Gutmann DH: Natural history of neurofibromatosis 1-associated optic nerve glioma in mice. Ann Neurol; 2005 Jan;57(1):119-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history of neurofibromatosis 1-associated optic nerve glioma in mice.
  • Children affected with the inherited tumor predisposition syndrome, neurofibromatosis 1 (NF1), are prone to the development of low-grade astrocytic optic pathway tumors (optic pathway glioma [OPG]).
  • Previously, we developed a model of NF1-associated astrocytoma (GFAPCre; Nf1(flox/mut) mice) in which mice develop optic nerve and chiasm glioma.
  • We observed that whereas astrocyte hyperplasia is present in the optic nerves associated with gross optic nerve thickening at 3 weeks of age, overt neoplastic changes were not seen until 2 months of age.
  • [MeSH-major] Glioma / complications. Neurofibromatosis 1 / complications. Optic Nerve Neoplasms / complications
  • [MeSH-minor] Age Factors. Animals. Animals, Newborn. Antigens / metabolism. Blood Vessels / physiology. Disease Models, Animal. Glial Fibrillary Acidic Protein / metabolism. Immunohistochemistry / methods. Indoles / metabolism. Intermediate Filament Proteins / metabolism. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging / methods. Mice. Mice, Transgenic. Nerve Tissue Proteins / metabolism. Nestin. Staining and Labeling / methods. von Willebrand Factor / immunology

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  • (PMID = 15622533.001).
  • [ISSN] 0364-5134
  • [Journal-full-title] Annals of neurology
  • [ISO-abbreviation] Ann. Neurol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R24 CA 83060; United States / NEI NIH HHS / EY / 5T32 EY 13360-03; United States / NINDS NIH HHS / NS / NS 36996; United States / NCI NIH HHS / CA / P30 CA 91842
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Glial Fibrillary Acidic Protein; 0 / Indoles; 0 / Intermediate Filament Proteins; 0 / Ki-67 Antigen; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / Von Willebrand antigen; 0 / von Willebrand Factor; 47165-04-8 / DAPI
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23. Hsu TR, Wong TT, Chang FC, Ho DM, Tang RB, Thien PF, Chang KP: Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children. Childs Nerv Syst; 2008 Dec;24(12):1457-61
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  • [Title] Responsiveness of progressive optic pathway tumors to cisplatin-based chemotherapy in children.
  • BACKGROUND: Though the pathology of optic pathway tumor is mostly pilocytic astrocytoma, the benign tumor behaves like malignant tumor because total resection is not feasible.
  • We evaluate the responsiveness of optic pathway tumor to cisplatin-based chemotherapy.
  • METHODS: Patients with unresectable and progressive optic pathway tumors received conventional chemotherapy including cisplatin, etoposide, and vinblastine were enrolled in this study from 1992 to 2007.
  • The pathology showed pilocytic astrocytomas in 11 patients, astrocytoma in one patient, and anaplastic astrocytomas in two patients.
  • CONCLUSION: Cisplatin-based chemotherapy is an effective regimen for control of progressive optic pathway tumors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / drug therapy. Optic Nerve Neoplasms / drug therapy

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  • (PMID = 18769928.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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24. Catrambone JE, He W, Prestigiacomo CJ, Carmel PW: Monitoring papilledema in a patient with pineal pilocytic astrocytoma by using Heidelberg Retina Tomograph II. Case report. J Neurosurg; 2007 Aug;107(2 Suppl):163-6
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  • [Title] Monitoring papilledema in a patient with pineal pilocytic astrocytoma by using Heidelberg Retina Tomograph II. Case report.
  • The Heidelberg Retina Tomograph (HRT) II is a confocal scanning laser device used to acquire images of the optic nerve head.
  • In this paper the authors report a novel use of this device in the assessment of papilledema in a patient with pilocytic astrocytoma of the pineal region.
  • They also present a new technique to objectively produce 3D data of the optic nerve head.
  • The authors analyzed the height variation of the retinal surface along the vertical and horizontal cross-lines passing the center of the optic nerve head.
  • The height variation of the retinal surface along the contour line created by the software demonstrated that elevation of the optic nerve head became depressed due to resolved swelling.
  • Initial data suggest that changes in the optic nerve head topography after surgical decompression can be quantitatively documented by 3D data from the HRT II.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Microscopy, Confocal / instrumentation. Papilledema / pathology. Pineal Gland. Tomography / instrumentation

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  • (PMID = 18459891.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. Sawamura Y, Kamada K, Kamoshima Y, Yamaguchi S, Tajima T, Tsubaki J, Fujimaki T: Role of surgery for optic pathway/hypothalamic astrocytomas in children. Neuro Oncol; 2008 Oct;10(5):725-33

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of surgery for optic pathway/hypothalamic astrocytomas in children.
  • Optic pathway/hypothalamic pilocytic astrocytomas in children are usually treated with chemotherapy following a surgical biopsy.
  • The 11 open biopsies revealed pilocytic astrocytoma; however, noticeable complications occurred in five children after the biopsies.
  • Review of preoperative MRIs showed that all had typical findings indicating pilocytic astrocytoma.
  • [MeSH-major] Astrocytoma / surgery. Hypothalamic Neoplasms / surgery. Optic Nerve Neoplasms / surgery

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  • (PMID = 18612049.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ PMC2666249
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26. Bommakanti K, Panigrahi M, Yarlagadda R, Sundaram C, Uppin MS, Purohit AK: Optic chiasmatic-hypothalamic gliomas: is tissue diagnosis essential? Neurol India; 2010 Nov-Dec;58(6):833-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optic chiasmatic-hypothalamic gliomas: is tissue diagnosis essential?
  • BACKGROUND: Optic chiasmatic-hypothalamic gliomas are sellar-suprasellar lesions with variable radiological features.
  • However, in developing countries, like India infective granulomas (tuberculomas) in the suprasellar region radiologically can mimic optic chiasmatic-hypothalamic gliomas.
  • PATIENTS AND METHODS: The magnetic resonance imaging (MRI) characteristics of 24 patients with either histologically proven optic chiasmatic "pilocytic astrocytoma" or radiologically suspected optic chiasmatic-hypothalamic gliomas were analyzed.
  • RESULTS: The three radiological groups were: Group-1 solid tumors with or without microcysts in 9 patients (histology: 8 pilocystic astrocytomas and 1 tuberculoma); Group-2 mixed tumors with solid and cystic components in 9 patients (histology: 7 pilocytic astrocytomas and 2 craniopharyngiomas); Group-3 ring enhancing lesions in 6 patients (all the 6 patients initially received antituberculous treatment, in 3 patients the lesion resolved and in the remaining 3 patients the lesion was subjected to biopsy as it did not resolve, the biopsy was suggestive of pilocytic astrocytoma).
  • Thus, MRI was shown to have a sensitivity of 83.33% and a specificity of 50% for diagnosing optic chiasmatic-hypothalamic gliomas.
  • CONCLUSIONS: Various lesions like craniopharyngiomas, tuberculomas can mimic optic chiasmatic-hypothalamic gliomas radiologically, and it is not possible to diagnose them with certainty on the basis of radiological findings alone.
  • Biopsy and tissue diagnosis should always be sought before instituting radiotherapy or chemotherapy for optic chiasmatic-hypothalamic gliomas.
  • [MeSH-major] Glioma / diagnosis. Hypothalamic Neoplasms / diagnosis. Optic Chiasm / pathology. Optic Nerve Neoplasms / diagnosis

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  • [CommentIn] Neurol India. 2011 Jan-Feb;59(1):144 [21339694.001]
  • (PMID = 21150045.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Contrast Media
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27. Suárez JC, Viano JC, Zunino S, Herrera EJ, Gomez J, Tramunt B, Marengo I, Hiramatzu E, Miras M, Pena M, Sonzini Astudillo B: Management of child optic pathway gliomas: new therapeutical option. Childs Nerv Syst; 2006 Jul;22(7):679-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of child optic pathway gliomas: new therapeutical option.
  • OBJECTIVE: To present our experience in the treatment of child optic pathway gliomas in the last 25 years.
  • Diagnosed using computed tomography or/and magnetic resonance imaging, histological studies showed pilocytic astrocytomas in 13 cases and a fibrillary astrocytoma grade II in 1 case.
  • [MeSH-major] Glioma / therapy. Optic Nerve Glioma / therapy. Optic Nerve Neoplasms / therapy

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  • (PMID = 16389565.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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28. Zoeller GK, Brathwaite CD, Sandberg DI: Malignant transformation of an optic pathway glioma without prior radiation therapy. J Neurosurg Pediatr; 2010 May;5(5):507-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of an optic pathway glioma without prior radiation therapy.
  • Optic pathway gliomas (OPGs) arise from the optic nerves, optic chiasm, and/or hypothalamus and most commonly occur in childhood.
  • The authors report the first case in the English literature of an OPG that transformed from a low-grade astrocytoma, with features most consistent with a pilocytic astrocytoma, to a malignant glioma without any exposure to radiation therapy.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Optic Nerve Glioma / pathology
  • [MeSH-minor] Antineoplastic Agents, Alkylating / therapeutic use. Chemotherapy, Adjuvant. Child, Preschool. Combined Modality Therapy. Cranial Irradiation. Craniotomy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Fatal Outcome. Humans. Hypothalamus / pathology. Hypothalamus / surgery. Magnetic Resonance Imaging. Male. Neoplasms, Radiation-Induced / pathology. Optic Chiasm / pathology. Optic Chiasm / surgery. Optic Nerve / pathology. Optic Nerve / surgery. Radiotherapy, Adjuvant

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  • (PMID = 20433265.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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29. Jaing TH, Lin KL, Tsay PK, Hsueh C, Hung PC, Wu CT, Tseng CK: Treatment of optic pathway hypothalamic gliomas in childhood: experience with 18 consecutive cases. J Pediatr Hematol Oncol; 2008 Mar;30(3):222-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of optic pathway hypothalamic gliomas in childhood: experience with 18 consecutive cases.
  • The aim of this study was to present our 17-year experience (1989 to 2006) in the treatment of optic pathway/hypothalamic gliomas (OPHG) in 18 children younger than 17 years (median age, 66 mo).
  • Histologic studies showed low-grade astrocytoma (WHO grade I or II) in 16 cases, anaplastic astrocytoma in 1, and oligoastrocytoma (WHO grade III) in 1.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hypothalamic Neoplasms / therapy. Optic Nerve Glioma / therapy. Visual Pathways / pathology

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  • (PMID = 18376285.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Roselli F, Pisciotta NM, Aniello MS, Niccoli-Asabella A, Defazio G, Livrea P, Rubini G: Brain F-18 Fluorocholine PET/CT for the assessment of optic pathway glioma in neurofibromatosis-1. Clin Nucl Med; 2010 Oct;35(10):838-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain F-18 Fluorocholine PET/CT for the assessment of optic pathway glioma in neurofibromatosis-1.
  • Magnetic resonance imaging, magnetic resonance spectroscopy (MRS), and F-18 fluorocholine revealed a splenial mass with imaging features compatible with malignant astrocytoma.
  • Molecular imaging of optic pathway gliomas may be a valuable tool in the selection of therapeutic options.
  • [MeSH-major] Brain. Choline / analogs & derivatives. Glioma / diagnosis. Neurofibromatosis 1 / diagnosis. Optic Nerve. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20838306.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / fluorocholine; N91BDP6H0X / Choline
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31. Scheithauer BW, Silva AI, Ketterling RP, Pula JH, Lininger JF, Krinock MJ: Rosette-forming glioneuronal tumor: report of a chiasmal-optic nerve example in neurofibromatosis type 1: special pathology report. Neurosurgery; 2009 Apr;64(4):E771-2; discussion E772
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rosette-forming glioneuronal tumor: report of a chiasmal-optic nerve example in neurofibromatosis type 1: special pathology report.
  • OBJECTIVE: Rosette-forming glioneuronal tumor is a rare, rather recently described tumor featuring a highly distinctive, biphasic histological pattern, including a cytologically uniform neuronal component of Homer-Wright type pseudorosettes and an accompanying astrocytic element resembling pilocytic astrocytoma.
  • [MeSH-major] Neurofibromatosis 1 / pathology. Optic Chiasm / pathology. Optic Nerve Neoplasms / pathology
  • [MeSH-minor] Astrocytoma / pathology. Humans. Magnetic Resonance Imaging / methods. Male. Young Adult

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  • (PMID = 19349806.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Ganesh S, Gupta A, Sharma M, Bhuttan S: A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course. Indian J Ophthalmol; 2008 Mar-Apr;56(2):161-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course.
  • Optic pathway glioma associated with neurofibromatosis 1 has a classically indolent course.
  • However, involvement of the optic radiations is relatively rare and is associated with a more aggressive course.
  • A three-year-old girl presented with strabismus and loss of vision in the left eye with relative afferent pupillary defect and optic disc pallor.
  • Visually evoked potential was suggestive of an optic nerve conduction defect and magnetic resonance imaging of the brain was suggestive of an optic pathway glioma involving the optic nerves, the optic chiasma and the optic tracts.
  • The optic radiations and the dendate nuclei had hamartomas.
  • Optic nerve biopsy confirmed pilocytic astrocytoma.
  • This case report aims to highlight the involvement of the optic radiations and the unusually aggressive clinical course in this case.
  • [MeSH-major] Neurofibromatosis 1 / pathology. Optic Chiasm / pathology. Optic Nerve Glioma / pathology. Optic Nerve Neoplasms / pathology

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  • [Cites] Am J Ophthalmol. 2001 Apr;131(4):442-5 [11292406.001]
  • [Cites] Arch Pediatr. 2002 Jan;9(1):49-60 [11865551.001]
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  • (PMID = 18292634.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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33. Pascual-Castroviejo I, Pascual-Pascual SI, Velázquez-Fragua R, Viaño J, García-Segura JM, Botella MP: [Neurofibromatosis type 1 and optic pathway gliomas. A series of 80 patients]. Rev Neurol; 2008 May 1-15;46(9):530-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neurofibromatosis type 1 and optic pathway gliomas. A series of 80 patients].
  • PATIENTS AND METHODS: From a series of 530 patients with neurofibromatosis type 1 (NF1), we performed a retrospective assessment of the long-term neurologic, visual, neuroimaging and evolution of 80 patients (15%) with optic pathway gliomas (OPG).
  • RESULTS: Image studies showed the distribution of the lesions among optic nerves, chiasm, tracts and radiations demonstrated that only 25% of the tumors involved only one optic nerve and 11.5% were located only in the chiasm, while 40% involved one or both optic nerves and chiasm, tracts and radiations.
  • Two patients showed pilocytic astrocytoma in the histological study.
  • Despite the apparent tumoral agressivity of the magnetic resonance and magnetic resonance spectroscopy images, histological findings corresponded to benign pilocytic astrocytoma.
  • [MeSH-major] Neoplasms, Multiple Primary / diagnosis. Neurofibromatosis 1 / diagnosis. Optic Nerve Glioma / diagnosis

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  • (PMID = 18446694.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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34. Warrington NM, Woerner BM, Daginakatte GC, Dasgupta B, Perry A, Gutmann DH, Rubin JB: Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1. Cancer Res; 2007 Sep 15;67(18):8588-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.
  • Astrocytoma (glioma) formation in neurofibromatosis type 1 (NF1) occurs preferentially along the optic pathway during the first decade of life.
  • Previous studies in mouse Nf1 optic glioma models suggest that this patterning results from cooperative effects of Nf1 loss in glial cells and the action of factors derived from the surrounding Nf1+/- brain.
  • In support of an instructive role for CXCL12 in facilitating optic glioma growth, we also show that CXCL12 expression along the optic pathway is higher in infant children and young mice and is associated with low levels of cAMP.
  • [MeSH-major] Brain Neoplasms / pathology. Chemokine CXCL12 / biosynthesis. Cyclic AMP / metabolism. Neurofibromatosis 1 / pathology. Optic Nerve Glioma / pathology


35. Marec-Berard P, Szathmari A, Conter C, Mottolese C, Berlier P, Frappaz D: Improvement of diencephalic syndrome after partial surgery of optic chiasm glioma. Pediatr Blood Cancer; 2009 Sep;53(3):502-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improvement of diencephalic syndrome after partial surgery of optic chiasm glioma.
  • Pathological examination revealed a pilocytic astrocytoma.
  • [MeSH-major] Hypothalamic Diseases / etiology. Optic Chiasm. Optic Nerve Glioma / complications. Optic Nerve Glioma / surgery

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  • [Copyright] (c) 2009 Wiley-Liss,
  • (PMID = 19489055.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Scheithauer BW, Erdogan S, Rodriguez FJ, Burger PC, Woodruff JM, Kros JM, Gokden M, Spinner RJ: Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: a clinicopathologic study of 17 cases. Am J Surg Pathol; 2009 Mar;33(3):325-38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: a clinicopathologic study of 17 cases.
  • Malignant peripheral nerve sheath tumors (MPNSTs) arising from cranial nerves or their branches are very uncommon.
  • In addition, 1 tumor involved the optic chiasm (n=1).
  • Four patients had postirradiation malignant peripheral nerve sheath tumors, 2 having been treated for optic chiasm glioma, both being NF1 affected.
  • One patient was irradiated for hypothalamic pilocytic astrocytoma and another for cervical Hodgkin disease.
  • Malignant cranial nerve sheath tumors are rare and are associated with the same poor prognosis as those of spinal nerves at other sites.
  • [MeSH-major] Brain Neoplasms / pathology. Cranial Nerve Neoplasms / pathology. Nerve Sheath Neoplasms / pathology

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  • (PMID = 19065105.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Trivin C, Couto-Silva AC, Sainte-Rose C, Chemaitilly W, Kalifa C, Doz F, Zerah M, Brauner R: Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin Endocrinol (Oxf); 2006 Aug;65(2):239-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These were optic glioma or astrocytoma (n = 45), hydrocephalus (n = 22), hypothalamic hamartoma (n = 15), suprasellar arachnoid cyst (n = 10) and others (n = 8).
  • The boys with hamartoma were significantly taller and had greater bone age advance, LH peak and testosterone than boys with optic glioma.
  • All patients treated for optic glioma had hypothalamic-pituitary deficiencies, including GH (100%), thyrotrophin (71.4%), corticotrophin (12.5%) and pubertal (34.3%) deficiencies.
  • [MeSH-minor] Adolescent. Adult. Arachnoid Cysts / blood. Arachnoid Cysts / complications. Astrocytoma / blood. Astrocytoma / complications. Body Height. Child. Child, Preschool. Female. Follicle Stimulating Hormone / blood. Gonadal Steroid Hormones / blood. Growth Hormone / blood. Growth Hormone-Releasing Hormone. Hamartoma / blood. Hamartoma / complications. Humans. Hydrocephalus / blood. Hydrocephalus / complications. Hydrocortisone / blood. Hypothalamic Neoplasms / blood. Hypothalamic Neoplasms / complications. Luteinizing Hormone / blood. Male. Meningomyelocele / blood. Meningomyelocele / complications. Optic Nerve Glioma / blood. Optic Nerve Glioma / complications. Statistics, Nonparametric


38. Huber J, Sovinz P, Lackner H, Mokry M, Eder H, Urban C: Diencephalic syndrome: a frequently delayed diagnosis in failure to thrive. Klin Padiatr; 2007 Mar-Apr;219(2):91-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is associated with neoplastic lesions of the hypothalamic-optic chiasmatic region.
  • Imaging of the brain showed a suprasellar mass, identified histologically as low grade pilocytic astrocytoma.
  • CONCLUSIONS: Diencephalic syndrome caused by a hypothalamic/chiasmatic astrocytoma is a rare cause of failure to thrive in children so that diagnosis is frequently delayed.
  • [MeSH-major] Astrocytoma / diagnosis. Failure to Thrive / etiology. Hypothalamic Diseases / diagnosis. Hypothalamic Neoplasms / diagnosis. Optic Chiasm. Optic Nerve Neoplasms / diagnosis

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  • (PMID = 17405074.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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39. Jalali R, Deopujari CE, Bhutani R, Suhas U, Rajasekharan P, Kane SV, Gupta T: Suprasellar ganglioglioma with unusual diffuse involvement of the entire optico-chiasmal hypothalamic pathway. J Cancer Res Ther; 2008 Jul-Sep;4(3):140-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Magnetic resonance imaging (MRI) of the brain revealed an intensely enhancing mass lesion with calcification in the sellar and suprasellar region involving the optic chiasm and the left optic nerve.
  • The mass showed almost bilaterally symmetrical diffuse spread along the optic tracts posteriorly and hypothalamus, temporal lobes, thalami and the basal ganglia.
  • The lesion was radiologically indistinguishable from chiasmatic astrocytoma or a germ cell tumor but histopathological features were of a ganglioglioma.
  • While a few optic apparatus gangliogliomas have been reported in the literature, such widespread diffuse involvement of the entire optico-chiasmal hypothalamic pathway is unusual.
  • [MeSH-major] Brain Neoplasms / pathology. Ganglioglioma / pathology. Hypothalamus / pathology. Optic Chiasm / pathology. Visual Pathways / pathology

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  • (PMID = 18923209.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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40. Hawes JJ, Reilly KM: Bioluminescent approaches for measuring tumor growth in a mouse model of neurofibromatosis. Toxicol Pathol; 2010 Jan;38(1):123-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibomatosis (NF1) patients are susceptible to multiple tumors of the nervous system including neurofibromas, optic glioma, malignant peripheral nerve sheath tumors (MPNSTs), and astrocytoma.
  • The Nf1+/-;Trp53+/- (NPcis) mouse model of NF1 spontaneously develops astrocytoma and MPNSTs that are very similar to human NF1 tumors.
  • [MeSH-minor] Animals. Astrocytoma / pathology. Cytomegalovirus / genetics. Genes, p53. Humans. Magnetic Resonance Imaging. Mice. Mice, Inbred C57BL. Nerve Sheath Neoplasms / pathology. Promoter Regions, Genetic

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  • (PMID = 20176786.001).
  • [ISSN] 1533-1601
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Grant] United States / PHS HHS / / HHSN261200800001E; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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41. Jalali R, Mallick I, Dutta D, Goswami S, Gupta T, Munshi A, Deshpande D, Sarin R: Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys; 2010 Jul 15;77(4):974-9
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  • METHODS AND MATERIALS: Twenty-eight patients (median age, 13 years) with residual/progressive brain tumors (10 craniopharyngioma, 8 cerebellar astrocytoma, 6 optic pathway glioma and 4 cerebral low-grade glioma) were treated with SCRT to a dose of 54 Gy in 30 fractions over 6 weeks.
  • [MeSH-minor] Adolescent. Astrocytoma / radiotherapy. Cerebellar Neoplasms / psychology. Cerebellar Neoplasms / radiotherapy. Child. Cognition / radiation effects. Craniopharyngioma / psychology. Craniopharyngioma / radiotherapy. Female. Humans. Male. Optic Nerve Glioma / radiotherapy. Prospective Studies. Radiotherapy, Conformal / methods. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19864079.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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42. Solivera J, Navarro R, Costa JM: Orbital emphysema after endoscopic third ventriculostomy and posterior fossa surgery in the sitting position. Childs Nerv Syst; 2007 Jan;23(1):27-9
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  • INTRODUCTION: Orbital emphysema can be associated with optic nerve and vascular compromise, with subsequent potentially irreversible visual loss.
  • MATERIALS AND METHODS: We report a 4-year-old girl who presented right orbital emphysema after posterior fossa surgery for pilocytic astrocytoma resection in the sitting position.
  • [MeSH-major] Astrocytoma / surgery. Hydrocephalus / surgery. Neurosurgical Procedures / adverse effects. Orbital Diseases / etiology. Posture. Ventriculostomy

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  • (PMID = 17089169.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. Naranjo C, Schobert C, Dubielzig R: Canine ocular gliomas: a retrospective study. Vet Ophthalmol; 2008 Nov-Dec;11(6):356-62
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  • OBJECTIVE: The purpose of this paper is to classify glial tumors observed in the canine retina and optic nerve, describe the histopathological features and provide prognostic information on these neoplasms.
  • In 6 of the 8 dogs that had died during this stud), tumor extended to the margin where the optic nerve had been sectioned.
  • Light microscopic examination of the optic nerve of the affected eyes of four dogs that were still alive during this study revealed no tumor at this surgical margin.
  • One neoplasm was classified as low-grade astrocytoma, 5 tumors as medium-grade astrocytoma, 11 tumors as high grade-astrocytoma and 1 tumor as oligodendroglioma.
  • CONCLUSION: Retinal and optic nerve gliomas may be considered as differential diagnoses of intraocular and orbital masses.
  • [MeSH-major] Dog Diseases / pathology. Eye Neoplasms / veterinary. Optic Nerve Glioma / veterinary. Retinal Neoplasms / veterinary. Retinoblastoma / veterinary

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  • (PMID = 19046275.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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44. Wu-Chen WY, Jacobs DA, Volpe NJ, Dalmau JO, Moster ML: Intracranial malignancies occurring more than 20 years after radiation therapy for pituitary adenoma. J Neuroophthalmol; 2009 Dec;29(4):289-95
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  • A 37-year-old woman developed a left third cranial nerve palsy 28 years after radiation for a nonsecreting pituitary adenoma.
  • A 63-year-old man developed a malignant astrocytoma of the left optic nerve and chiasm 23 years after partial excision and radiation of a nonsecreting pituitary adenoma.
  • [MeSH-major] Adenoma / radiotherapy. Brain Stem Neoplasms / etiology. Glioma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Optic Nerve Neoplasms / etiology. Pituitary Neoplasms / radiotherapy

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  • (PMID = 19952902.001).
  • [ISSN] 1536-5166
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Syrbe S, Eberle K, Strenge S, Bernhard MK, Herbertz S, Bierbach U, Hirsch W, Froster UG, Kiess W, Merkenschlager A: [Neurofibromatosis type 1 and associated clinical abnormalities in 27 children]. Klin Padiatr; 2007 Nov-Dec;219(6):326-32
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  • Besides the classic criteria café-au-lait spots (100%), freckling (48,1%), positive family history (44,1%), neurofibromas (40,7%), Lisch nodules (22,2%) and optic pathway tumors (22,2%) there were developmental delay (40,7%), macrocephaly (33,3%), strabism (29,6%), scoliosis (18,5%), epilepsy (14,8%), pubertal anomalies (14,8%), short stature (11,1%) and tics.
  • Regular screening of optic glioma with MRI had no clinical significance.
  • In contrast to other authors, one of our patients with optic glioma showed clinical progress after twelve years of age.
  • [MeSH-minor] Adolescent. Age Factors. Astrocytoma / diagnosis. Astrocytoma / etiology. Brain Neoplasms / diagnosis. Brain Neoplasms / etiology. Cardiovascular Diseases / etiology. Child. Child, Preschool. Diagnosis, Differential. Female. Genes, Neurofibromatosis 1. Genotype. Hamartoma / diagnosis. Hamartoma / etiology. Humans. Infant. Magnetic Resonance Imaging. Male. Mutation. Optic Nerve Glioma / diagnosis. Optic Nerve Glioma / etiology. Phenotype. Temporal Lobe. Xanthogranuloma, Juvenile / diagnosis. Xanthogranuloma, Juvenile / etiology

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  • (PMID = 18183640.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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46. Jallo GI, Bognár L: Eyebrow surgery: the supraciliary craniotomy: technical note. Neurosurgery; 2006 Jul;59(1 Suppl 1):ONSE157-8; discussion ONSE157-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Astrocytoma / surgery. Cranial Fossa, Anterior / surgery. Craniotomy / methods. Frontal Bone / surgery. Minimally Invasive Surgical Procedures / methods. Optic Nerve Neoplasms / surgery. Sella Turcica / surgery
  • [MeSH-minor] Adolescent. Bone Plates / standards. Cerebral Arteries / anatomy & histology. Cerebral Arteries / surgery. Dura Mater / anatomy & histology. Dura Mater / surgery. Eyebrows / anatomy & histology. Female. Frontal Lobe / anatomy & histology. Frontal Lobe / surgery. Humans. Intraoperative Complications / prevention & control. Magnetic Resonance Imaging. Medical Illustration. Optic Chiasm / anatomy & histology. Optic Chiasm / pathology. Optic Chiasm / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Subarachnoid Space / anatomy & histology. Subarachnoid Space / surgery. Treatment Outcome

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  • (PMID = 16888559.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Dasgupta B, Yi Y, Hegedus B, Weber JD, Gutmann DH: Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma. Cancer Res; 2005 Nov 1;65(21):9843-50
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  • Individuals affected with the neurofibromatosis 1 (NF1) tumor predisposition syndrome are prone to the development of multiple nervous system tumors, including optic pathway gliomas (OPG).
  • As part of a larger effort to identify protein markers for NF1-associated astrocytomas that could be exploited for therapeutic drug design, we did an objective proteomic analysis of the cerebrospinal fluid from genetically engineered Nf1 mice with optic glioma.
  • [MeSH-major] Aminopeptidases / cerebrospinal fluid. Glioma / cerebrospinal fluid. Metalloendopeptidases / cerebrospinal fluid. Neurofibromatosis 1 / cerebrospinal fluid. Optic Nerve Neoplasms / cerebrospinal fluid
  • [MeSH-minor] Amino Acid Sequence. Animals. Astrocytes / cytology. Astrocytes / drug effects. Astrocytes / pathology. Astrocytoma / cerebrospinal fluid. Astrocytoma / complications. Astrocytoma / enzymology. Astrocytoma / genetics. Cell Growth Processes / drug effects. Cyclohexanes. Fatty Acids, Unsaturated / pharmacology. Gene Silencing. Glycoproteins / antagonists & inhibitors. Glycoproteins / biosynthesis. Glycoproteins / cerebrospinal fluid. Glycoproteins / genetics. Humans. Mice. Mice, Transgenic. Molecular Sequence Data. Neurofibromin 1 / deficiency. Neurofibromin 1 / genetics. Proteomics. Sesquiterpenes. Tumor Suppressor Proteins / genetics

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  • (PMID = 16267007.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclohexanes; 0 / Fatty Acids, Unsaturated; 0 / Glycoproteins; 0 / Neurofibromin 1; 0 / Sesquiterpenes; 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 7OW73204U1 / fumagillin; EC 3.4.11.- / Aminopeptidases; EC 3.4.11.18 / Metap2 protein, mouse; EC 3.4.11.18 / methionine aminopeptidase 2; EC 3.4.24.- / Metalloendopeptidases
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48. Akiyama H, Nakamizo S, Kawamura A, Nagashima T, Takeda H, Hasegawa D, Kosaka Y, Yoshida M: [Management of chiasmatic-hypothalamic gliomas in children: report of nine pediatric cases]. No Shinkei Geka; 2007 Nov;35(11):1079-85
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  • Pathological examination revealed pilocytic astrocytomas in 7 patients, low grade astrocytoma in 1 and anaplastic astrocytoma in 1.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Glioma / surgery. Hypothalamic Neoplasms / surgery. Optic Chiasm. Optic Nerve Glioma / surgery

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  • (PMID = 18044225.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin
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49. Paixão Becker A, de Oliveira RS, Saggioro FP, Neder L, Chimelli LM, Machado HR: In pursuit of prognostic factors in children with pilocytic astrocytomas. Childs Nerv Syst; 2010 Jan;26(1):19-28
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  • The most common site of tumor formation was the cerebellum (17), followed by brainstem (4), optic chiasmatic hypothalamic region (4), cerebral hemisphere (3), cervical spinal cord (2), and optic nerve (1).
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 19823847.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Ki-67 Antigen
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50. Dasgupta B, Yi Y, Chen DY, Weber JD, Gutmann DH: Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors. Cancer Res; 2005 Apr 1;65(7):2755-60
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  • This mTOR pathway hyperactivation was reflected by high levels of ribosomal S6 activation in both Nf1 mutant mouse optic nerve gliomas and in human NF1-associated pilocytic astrocytoma tumors.

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  • (PMID = 15805275.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 1; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 90-kDa; W36ZG6FT64 / Sirolimus
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51. Staubach F, Pieh C, Maier P, Lagrèze WA: Relative afferent pupillary defect with normal vision and vertical strabismus--implications for pupillary pathway anatomy. Graefes Arch Clin Exp Ophthalmol; 2007 Feb;245(2):321-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Nerve Compression Syndromes / etiology. Optic Nerve Diseases / etiology. Pupil Disorders / etiology. Strabismus / etiology. Visual Pathways / pathology

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  • (PMID = 16552531.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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52. Stokland T, Liu JF, Ironside JW, Ellison DW, Taylor R, Robinson KJ, Picton SV, Walker DA: A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702). Neuro Oncol; 2010 Dec;12(12):1257-68
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  • From the cohort of 798 patients, 639 patients were eligible, with a median age 6.71 years (0.26-16.75 years); 49% were males; 15.9% had neurofibromatosis type 1, 63.7% pilocytic astrocytoma, 5.9% fibrillary astrocytoma, 4.2% mixed neuronal-glial tumors, and 3.6% others; 21.1% were diagnosed clinically.
  • Anatomically implicated were 31.6% cerebellum, 24.6% chiasma/hypothalamus, 16.0% cerebral hemispheres, 9.9% brain stem, 6.1% other supratentorial midline structures, 5.9% optic nerve only, 4.5% spinal cord, and 1.4% others.
  • Multivariate analysis identified young age, fibrillary astrocytoma, and extent of surgical resection as significant independent risk factors for progression.

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  • (PMID = 20861086.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3018938
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53. Perry A, Lusis EA, Gutmann DH: Meningothelial hyperplasia: a detailed clinicopathologic, immunohistochemical and genetic study of 11 cases. Brain Pathol; 2005 Apr;15(2):109-15
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  • All cases had at least one putative predisposing factor, including hemorrhage (7), chronic renal disease (5), old age (5), trauma (1), and an adjacent optic nerve pilocytic astrocytoma (1).

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  • (PMID = 15912882.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS41520
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers
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54. Avery RA, Liu GT: Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. Arch Pediatr Adolesc Med; 2010 May;164(5):489-90
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  • [Title] Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1.
  • [MeSH-minor] Astrocytoma / diagnosis. Astrocytoma / etiology. Attention Deficit Disorder with Hyperactivity / complications. Child. Diagnosis, Differential. Ectropion / diagnosis. Ectropion / etiology. Hamartoma / diagnosis. Hamartoma / etiology. Humans. Iris Neoplasms / diagnosis. Iris Neoplasms / etiology. Male. Optic Nerve Glioma / diagnosis. Optic Nerve Glioma / etiology


55. Groves MD, Katz RL: Low grade astrocytoma presenting with visual loss. J Neurooncol; 2008 Aug;89(1):49-50
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  • [Title] Low grade astrocytoma presenting with visual loss.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Optic Nerve Neoplasms / secondary. Spinal Cord Neoplasms / secondary. Thalamus / pathology. Vision, Low / etiology
  • [MeSH-minor] Adolescent. Antineoplastic Agents, Alkylating / pharmacology. Antineoplastic Agents, Alkylating / therapeutic use. Biomarkers, Tumor. Dacarbazine / analogs & derivatives. Dacarbazine / pharmacology. Dacarbazine / therapeutic use. Humans. Intracranial Hypertension / etiology. Intracranial Hypertension / physiopathology. Magnetic Resonance Imaging. Male. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Optic Nerve / pathology. Optic Nerve / physiopathology. PTEN Phosphohydrolase / genetics. Papilledema / etiology. Papilledema / physiopathology. Phosphatidylinositol 3-Kinases / genetics. Receptor, Epidermal Growth Factor / genetics. Subarachnoid Space / pathology. Subarachnoid Space / physiopathology

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  • (PMID = 18398571.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Biomarkers, Tumor; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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56. Pasol J, Sternau L, Luetmer P, Giannini C: Rapid progressive unilateral visual loss in an elderly man. J Neuroophthalmol; 2010 Jun;30(2):188-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Astrocytoma / diagnosis. Optic Nerve / pathology. Optic Nerve Neoplasms / diagnosis. Vision, Low / etiology
  • [MeSH-minor] Acute Disease. Aged. Biopsy. Blindness / etiology. Craniotomy. Diabetes Mellitus. Diagnosis, Differential. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Methylprednisolone / therapeutic use. Optic Neuritis / diagnosis. Optic Neuritis / physiopathology. Optic Neuropathy, Ischemic / diagnosis. Optic Neuropathy, Ischemic / physiopathology. Papilledema / etiology. Radiotherapy / standards

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  • (PMID = 20523195.001).
  • [ISSN] 1536-5166
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] X4W7ZR7023 / Methylprednisolone
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