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1. Maria BL, Gupta N, Gilg AG, Abdel-Wahab M, Leonard AP, Slomiany M, Wheeler WG, Tolliver LB, Babcock MA, Lucas JT Jr, Toole BP: Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas. J Child Neurol; 2008 Oct;23(10):1214-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas.
  • Although significant advances have been made in treating malignant pediatric central nervous system tumors such as medulloblastoma, no effective therapy exists for diffuse pontine glioma or intramedullary spinal astrocytoma.
  • Biology of these 2 tumors is poorly understood, in part because diffuse pontine gliomas are not treated surgically, and tumor specimens from intramedullary spinal astrocytomas are rare and minuscule.
  • We review the clinical course of pediatric intramedullary spinal astrocytoma and diffuse pontine glioma, and show expression of membrane proteins that interact with hyaluronan: CD44, extracellular matrix metalloproteinase inducer, and breast cancer resistance protein (BCRP/ABCG2).

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  • (PMID = 18952588.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R13 NS040925; United States / NCI NIH HHS / CA / R01 CA073839; United States / NINDS NIH HHS / NS / 5R13NS040925-09; United States / NCRR NIH HHS / RR / C06RR015455; United States / NCI NIH HHS / CA / R01 CA082867; United States / NCI NIH HHS / CA / CA073839; United States / NCRR NIH HHS / RR / C06 RR015455; United States / NCI NIH HHS / CA / CA082867
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / Antigens, CD44; 0 / BSG protein, human; 0 / Neoplasm Proteins; 136894-56-9 / Antigens, CD147; 9004-61-9 / Hyaluronic Acid
  • [Number-of-references] 23
  • [Other-IDs] NLM/ NIHMS463105; NLM/ PMC3641563
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2. Jang SY, Kong MH, Song KY, Frazee JG: Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult. J Korean Neurosurg Soc; 2009 Jun;45(6):381-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult.
  • The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report.
  • Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord.
  • The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II).
  • When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

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  • (PMID = 19609424.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2711238
  • [Keywords] NOTNLM ; Astrocytoma / Cranial metastases / Intramedullary / Spinal cord tumor
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3. Jeong SM, Chung YG, Lee JB, Shin IY: Intracranial dissemination from spinal cord anaplastic astrocytoma. J Korean Neurosurg Soc; 2010 Jan;47(1):68-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial dissemination from spinal cord anaplastic astrocytoma.
  • We report a case of intracranial dissemination developing approximately 4 months after partial removal of a spinal cord anplastic astrocytoma in a 22-year-old male.
  • Spinal magnetic resonance (MR) images disclosed multiple intramedullary lesions at the T3-11.
  • The tumor was partially removed.
  • The final histologic diagnosis was anaplastic astrocytoma.
  • He underwent computed tomography-guided stereotactic biopsy and histological appearance was consistent with anaplastic astrocytoma.
  • The clinical course indicates that the tumor originated in the spinal cord and extended into the subarachnoid space, first the spinal canal and later intracranial.

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  • [Cites] Neuropathology. 2006 Dec;26(6):519-27 [17203587.001]
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  • (PMID = 20157383.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2817520
  • [Keywords] NOTNLM ; Anaplastic astrocytoma / Intracranial dissemination / Spinal cord
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4. Robinson CG, Prayson RA, Hahn JF, Kalfas IH, Whitfield MD, Lee SY, Suh JH: Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord. Int J Radiat Oncol Biol Phys; 2005 Sep 1;63(1):91-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord.
  • PURPOSE: To determine survival and changes in neurologic function and Karnofsky performance status (KPS) in a series of patients treated for low-grade astrocytoma of the spinal cord during the past two decades.
  • METHODS: This study consisted of 14 patients with pathologically confirmed low-grade astrocytoma of the spinal cord who were treated between 1980 and 2003.
  • Neither overall survival nor progression-free survival was clearly correlated with any patient, tumor, or treatment factors.
  • CONCLUSION: Patients who undergo gross total resection of their tumor may be followed closely.
  • [MeSH-major] Astrocytoma / mortality. Spinal Cord Neoplasms / mortality

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  • (PMID = 16111576.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Komotar RJ, Carson BS, Rao C, Chaffee S, Goldthwaite PT, Tihan T: Pilomyxoid Astrocytoma of the Spinal Cord: Report of Three Cases. Neurosurgery; 2005 Jan 01;56(1):E206-E210

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid Astrocytoma of the Spinal Cord: Report of Three Cases.

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  • (PMID = 28184642.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Tsutsumi S, Higo T, Kondo A, Abe Y, Yasumoto Y, Ito M: Atypical cervical astrocytoma manifesting as occipitalgia. Neurol Med Chir (Tokyo); 2007 Aug;47(8):371-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical cervical astrocytoma manifesting as occipitalgia.
  • Cervical MR imaging revealed a cervical intramedullary tumor.
  • Intraoperatively the subpial tumor was found to stretch the 3rd-5th dorsal nerve roots posteriorly, which was thought to cause the intolerable headache.
  • Total tumor resection was achieved without requiring myelotomy using electrophysiological monitoring with somatosensory and motor evoked potentials.
  • Histological examination identified diffuse astrocytoma.
  • Cervical astrocytoma of subpial location is a very rare cause of headache in adults.
  • [MeSH-major] Astrocytoma / complications. Astrocytoma / pathology. Headache / etiology. Spinal Cord / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Evoked Potentials / physiology. Female. Humans. Magnetic Resonance Imaging. Monitoring, Intraoperative. Neurosurgical Procedures. Pia Mater / pathology. Pia Mater / surgery. Spinal Nerve Roots / pathology. Spinal Nerve Roots / physiopathology. Subarachnoid Space / pathology. Subarachnoid Space / surgery. Treatment Outcome

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  • (PMID = 17721055.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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7. Matsuzaki K, Kageji T, Watanabe H, Hirose T, Nagahiro S: Pilomyxoid astrocytoma of the cervical spinal cord successfully treated with chemotherapy: case report. Neurol Med Chir (Tokyo); 2010;50(10):939-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid astrocytoma of the cervical spinal cord successfully treated with chemotherapy: case report.
  • A 15-month-old girl presented with a spinal pilomyxoid astrocytoma manifesting as a 3-month history of dysphagia.
  • Magnetic resonance imaging showed an intramedullary mass of the cervical spinal cord at C1-C6 with syringobulbia.
  • She underwent partial removal of the tumor and received postoperative chemotherapy with cisplatin and etoposide.
  • The tumor completely responded to the treatment and has not relapsed for 64 months.
  • Pilomyxoid astrocytoma frequently occurs in the opticohypothalamic regions but is rare in the spine.
  • The present case suggests that surgery followed by chemotherapy with cisplatin and etoposide may be an effective therapeutic option for pilomyxoid astrocytoma of the cervical spinal cord.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / therapy. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / therapy

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  • (PMID = 21030812.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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8. Pareés I, Alonso J, Rovira A, Martínez E, Montalban X: [Diffuse astrocytoma presenting as an optic-spinal syndrome]. Rev Neurol; 2009 Apr 1-15;48(7):354-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diffuse astrocytoma presenting as an optic-spinal syndrome].
  • [Transliterated title] Síndrome opticomedular como forma de presentación de un astrocitoma difuso.
  • INTRODUCTION: Spinal cord involvement is a rare presentation of grade II astrocytomas.
  • A patient with an optic-spinal syndrome due to a fibrillary astrocytoma is described.
  • CASE REPORT: A 32 years-old man was admitted to the hospital because of a subacute spinal cord syndrome.
  • Brain MRI showed no abnormalities, and spinal MRI disclosed a cervical cord lesion suggestive of myelitis.
  • A new MRI with spectroscopy revealed an infiltrative lesion involving the right frontal lobe, optic chiasm, internal capsule, brainstem and cervical spinal cord, which was suggestive of low-grade astrocytoma.
  • Brain biopsy confirmed the diagnosis of diffuse fibrillary astrocytoma.
  • [MeSH-major] Astrocytoma. Demyelinating Diseases. Optic Neuritis. Spinal Cord / pathology

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  • (PMID = 19319816.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Oligoclonal Bands
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9. Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP: Prognosis and treatment of spinal cord astrocytoma. Int J Radiat Oncol Biol Phys; 2009 Mar 1;73(3):727-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognosis and treatment of spinal cord astrocytoma.
  • PURPOSE: To identify the prognostic factors for spinal cord astrocytoma and determine the effects of surgery and radiotherapy on outcome.
  • METHODS AND MATERIALS: This retrospective study reviewed the cases of consecutive patients with spinal cord astrocytoma treated at Mayo Clinic Rochester between 1962 and 2005.
  • Of these 136 patients, 69 had pilocytic and 67 had infiltrative astrocytoma.
  • CONCLUSION: The results of our study have shown that histologic type is the most important prognostic variable affecting the outcome of spinal cord astrocytomas.
  • [MeSH-major] Astrocytoma / radiotherapy. Astrocytoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery

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  • (PMID = 18687533.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Komotar RJ, Carson BS, Rao C, Chaffee S, Goldthwaite PT, Tihan T: Pilomyxoid astrocytoma of the spinal cord: report of three cases. Neurosurgery; 2005;56(1):191
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  • [Title] Pilomyxoid astrocytoma of the spinal cord: report of three cases.
  • OBJECTIVE AND IMPORTANCE: Pilomyxoid astrocytoma (PMA) is a recently described, rare, circumscribed glioma similar to pilocytic astrocytoma.
  • Despite its circumscribed nature, PMA implies a worse overall outcome than typical pilocytic astrocytoma.
  • Since these original reports, we have encountered three tumors in the spinal cord with histological features identical to those of PMA.
  • INTERVENTION: The first patient's cervical and thoracic neoplasm was treated with subtotal resection and multiple laminectomies and spinal fusion for recurrence.
  • The neonate underwent laminectomy and biopsy of his holocord tumor.
  • The cases presented in this report suggest that PMA can occur at a later age and can involve the spinal cord.
  • [MeSH-major] Astrocytoma
  • [MeSH-minor] Child. Humans. Infant, Newborn. Male. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery

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  • (PMID = 15617606.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Larson DB, Hedlund GL: Non-enhancing pilocytic astrocytoma of the spinal cord. Pediatr Radiol; 2006 Dec;36(12):1312-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-enhancing pilocytic astrocytoma of the spinal cord.
  • Pilocytic astrocytomas are among the most common intramedullary spinal cord tumors in the pediatric age group.
  • The presence of contrast enhancement is a major factor used to distinguish these tumors from other spinal cord lesions.
  • We present a case of histologically proved non-enhancing intramedullary spinal cord pilocytic astrocytoma in a 12-year-old girl.
  • This case represents an exception to the conventional wisdom that pediatric spinal neoplasms enhance with administration of intravenous contrast material.
  • [MeSH-major] Astrocytoma / diagnosis. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 17021719.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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12. Sajadi A, Janzer RC, Lu TL, Duff JM: Pilomyxoid astrocytoma of the spinal cord in an adult. Acta Neurochir (Wien); 2008 Jul;150(7):729-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid astrocytoma of the spinal cord in an adult.
  • We report a 45-year old woman with a pilomyxoid astrocytoma (PMA) of the cervical spinal cord with a rapid clinical course and fatal outcome.
  • [MeSH-major] Astrocytoma / genetics. Spinal Cord Neoplasms / genetics

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  • (PMID = 18536992.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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13. Arulrajah S, Huisman TA: Pilomyxoid astrocytoma of the spinal cord with cerebrospinal fluid and peritoneal metastasis. Neuropediatrics; 2008 Aug;39(4):243-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid astrocytoma of the spinal cord with cerebrospinal fluid and peritoneal metastasis.
  • Pilomyxoid astrocytoma (PMA) is a recently described rare tumor which is a variant of pilocytic astrocytoma (PA).
  • Spinal cord PMA has been reported in two articles in the past and none of the reported case had extraneural metastasis.
  • We report on a female child with cervical cord PMA with diffuse leptomeningeal metastasis involving the brain and spinal cord.
  • Two years later she presented with peritoneal carcinomatoses which was consistent with metastatic tumor via a ventriculoperitoneal (VP) shunt.
  • [MeSH-major] Astrocytoma / cerebrospinal fluid. Astrocytoma / pathology. Carcinoma / secondary. Peritoneal Neoplasms / secondary. Spinal Cord Neoplasms / cerebrospinal fluid. Spinal Cord Neoplasms / pathology

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  • (PMID = 19165714.001).
  • [ISSN] 0174-304X
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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14. Vassilyadi M, Michaud J: Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread. Pediatr Neurosurg; 2005 Jan-Feb;41(1):29-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread.
  • The lesion was subtotally resected (70%) and diagnosed as an astrocytoma (mostly Kernohan grade 2 but with areas of grade 3).
  • Chemotherapy was administered and follow-up spine MRI at 2 months did not reveal any residual tumor, however, the leptomeningeal enhancement persisted.
  • This case illustrates how a spinal cord astrocytoma can metastasize via spinocranial dispersion and present early with hydrocephalus rather than myelopathy.
  • [MeSH-major] Astrocytoma / pathology. Hydrocephalus / etiology. Meningeal Neoplasms / complications. Meningeal Neoplasms / secondary. Neoplastic Cells, Circulating. Spinal Cord Neoplasms / pathology

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15886510.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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15. Hassan F, Paluzzi A, Kayello R, Bradey N, Strachan RD: Hydrocephalus as presenting feature of spinal astrocytoma in a adolescent patient. Br J Neurosurg; 2008 Jun;22(3):433-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hydrocephalus as presenting feature of spinal astrocytoma in a adolescent patient.
  • We report the case of an adolescent with a thoracic spine astrocytoma whose initial presentation was communicating hydrocephalus.
  • We speculate that the mechanism may be reduced meningeal compliance due to meningeal spread of the tumour.
  • [MeSH-major] Astrocytoma / complications. Hydrocephalus / etiology. Spinal Cord Neoplasms / complications

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  • (PMID = 18568734.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Gibson CJ, Parry NM, Jakowski RM, Eshar D: Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris). Vet Pathol; 2008 Nov;45(6):934-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris).
  • Grossly, the bladder was large and flaccid and the cervical and lumbar spinal cord were regionally enlarged, light grey, and friable with multifocal hemorrhages.
  • The thoracic spinal cord was grossly normal.
  • Microscopically all regions of the spinal cord had similar changes, although the cervical and lumbar sections were most severely affected.
  • These regions were completely effaced by a moderately cellular infiltration of highly pleomorphic polygonal to spindle shaped cells, mineralization, and necrosis, which were most consistent with anaplastic astrocytoma.
  • The thoracic spinal cord white matter was similarly infiltrated by the neoplastic cells, with perivascular extension into the otherwise normal grey matter.
  • A diagnosis of anaplastic astrocytoma was confirmed using immunohistochemical stains that were positive for glial fibrillary acidic protein and S100.
  • [MeSH-major] Astrocytoma / veterinary. Hedgehogs. Spinal Cord Neoplasms / veterinary

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  • (PMID = 18984799.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Cuadrado-Pereira M, Rodriguez-Saenz J, Andujar-Felix J: Spinal cord high grade astrocytoma. Bol Asoc Med P R; 2007 Jan-Mar;99(1):60-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord high grade astrocytoma.
  • OBJECTIVES: To describe the medical history, psychosocial aspects and the rehabilitation management of a patient with a high-grade astrocytoma of the spinal cord.
  • To review the literature regarding the epidemiology, classification, treatment, prognosis, and outcomes of astrocytomas involving the spinal cord.
  • To discuss issues and controversies in the rehabilitation management of spinal cord high-grade astrocytomas.
  • SETTING: Inpatient Spinal Cord Injury Rehabilitation Unit of Veterans Affair Medical Center; San Juan, Puerto Rico.
  • RESULTS: Aggressive multimodality treatment including acute inpatient interdisciplinary rehabilitation approach provided excellent results exceeding survival time and functional expectations for a patientwith high-grade astrocytoma.
  • (1) the survival time of more than three years, which exceeded the expected survival time of ten months for a patient diagnosed with spinal cord high grade astrocytoma and (2) for the outcomes achieved through an intensive comprehensive acute inpatient interdisci-plinary rehabilitation program which helped the patient achieve previous premorbid functional goals.
  • [MeSH-major] Astrocytoma. Spinal Cord Neoplasms

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  • (PMID = 17616049.001).
  • [ISSN] 0004-4849
  • [Journal-full-title] Boletín de la Asociación Médica de Puerto Rico
  • [ISO-abbreviation] Bol Asoc Med P R
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Puerto Rico
  • [Number-of-references] 18
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18. Katoh N, Shirato H, Aoyama H, Onimaru R, Suzuki K, Hida K, Miyasaka K, Iwasaki Y: Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. J Neurooncol; 2006 May;78(1):63-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor.
  • PURPOSE: To retrospectively analyze the outcome of post-operative radiotherapy for spinal cord glioma with the emphasis on the hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumors.
  • MATERIALS AND METHODS: Forty-one patients with spinal cord glioma received post-operative radiotherapy between 1979 and 2003.
  • There were 12 low-grade astrocytic tumors, 11 high-grade astrocytic tumors, 16 low-grade ependymal tumors and 2 high-grade ependymal tumors.
  • Among 11 patients with high-grade astrocytic tumors, 5 with anaplastic astrocytoma and 1 with glioblastoma received hypofractionated radiotherapy boost for dose escalation.
  • RESULTS: The Kaplan-Meier survival rates at 10 years from the date of the first surgery were 64% for the entire group, 47% for the astrocytic tumors and 84% for the ependymal tumors, respectively (P=0.009).
  • Among 11 patients with high-grade astrocytic tumors, the actuarial survival rate at 10 years was 35%.
  • DISCUSSION: The results for ependymal tumors and low-grade astrocytic tumors were comparable to those reported in the literature.
  • Hypofractionated radiotherapy boost for dose escalation may help to prolong the survival of patients with high-grade astrocytic tumors.
  • [MeSH-major] Dose Fractionation. Glioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy

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  • (PMID = 16314938.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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19. Yoshino M, Morita A, Shibahara J, Kirino T: Radiation-induced spinal cord cavernous malformation. Case report. J Neurosurg; 2005 Jan;102(1 Suppl):101-4
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  • [Title] Radiation-induced spinal cord cavernous malformation. Case report.
  • The authors report a case of a 16-year-old girl who presented with progressive gait difficulty 8 years after undergoing spinal radiation therapy for spinal astrocytoma.
  • This is believed to be the third case of de novo formation of an intramedullary cavernous malformation following spinal radiation therapy.
  • [MeSH-major] Arteriovenous Malformations / etiology. Radiation Injuries / pathology. Spinal Cord Diseases / etiology
  • [MeSH-minor] Adolescent. Astrocytoma / radiotherapy. Female. Humans. Spinal Cord Neoplasms / radiotherapy. Time Factors

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  • (PMID = 16206743.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Kumandaş S, Per H, Gümüş H, Tucer B, Yikilmaz A, Kontaş O, Coşkun A, Kurtsoy A: Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature review. Neurosurg Rev; 2006 Oct;29(4):333-8; discussion 338
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  • [Title] Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature review.
  • Acquired torticollis is not a diagnosis but rather a sign of an underlying disorder.
  • The causes of acquired torticollis include ligamentous, muscular, osseous, ocular, psychiatric, and neurologic disorders and may be a symptom of significant abnormalities of the spinal cord and brain, such as spinal syrinx or central nervous system neoplasia.
  • Torticollis is rarely considered to be an initial clinical presentation of posterior fossa and cervical spinal cord tumors.
  • We report five cases of pediatric tumors with torticollis at the onset: an astrocytoma originating from the medulla oblongata, another presumptive astrocytoma of the spinal cord located between C1 and C6 cervical vertebrae (not operated), an ependymoma located throughout the whole cervical spinal cord extending into the bulbomedullary junction, an astrocytoma originating from the bulbus and extending into the posterior fossa, and another case of a eosinophilic granuloma located extradurally through the anterior and posterior portions of the vertebral bodies from C3 to C7 producing the collapse of the sixth cervical vertebra.
  • All these cases reflect the misinterpretation of this neurological sign and the lack of association with the possibility of spinal or posterior fossa tumor.
  • This delay in the diagnosis of these diseases led to progressive neurological deterioration and to the increase in the tumor size, which made surgical intervention difficult and the prognosis unfavorable.
  • [MeSH-major] Astrocytoma / complications. Eosinophilic Granuloma / complications. Ependymoma / complications. Infratentorial Neoplasms / complications. Spinal Cord Neoplasms / complications. Torticollis / etiology
  • [MeSH-minor] Child. Child, Preschool. Cranial Fossa, Posterior / pathology. Craniotomy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Spinal Cord / pathology. Tomography, X-Ray Computed

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  • (PMID = 16924460.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Porter A, Lyons MK, Wingerchuk DM, Bosch EP: Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. Clin Neurol Neurosurg; 2006 Dec;108(8):787-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension.
  • Increased intracranial pressure is rarely seen in association with spinal tumors.
  • The spinal MRI showed a low cervical-upper thoracic intramedullary tumor.
  • Open biopsy confirmed a grade 3 fibrillary astrocytoma.
  • The suspected mechanisms of spinal tumors causing increased intracranial pressure are reviewed as well as three other cases of spinal astrocytomas previously reported in the literature that presented with papilledema and increased intracranial pressure without hydrocephalus.
  • This case illustrates that increased intracranial pressure may in exceptional cases of spinal tumors precede the more typical myelopathic presentation by months and mimic idiopathic intracranial hypertension.
  • [MeSH-major] Astrocytoma / diagnosis. Pseudotumor Cerebri / etiology. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Disease Progression. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neurologic Examination. Papilledema / etiology. Spinal Cord / pathology. Tomography, X-Ray Computed. Vision Disorders / etiology

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  • (PMID = 16298472.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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22. Rovin RA, Winn R: Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report. J Neurosurg Spine; 2007 May;6(5):447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.
  • The authors report the case of a 28-year-old woman with a high-grade spinal cord astrocytoma.
  • Treatment using surgery, radiation, and temozolomide (TMZ) led to functional recovery and regression of the residual tumor as demonstrated on serial magnetic resonance images.
  • Genetic testing revealed that this tumor did not express the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).
  • This is the first report in the literature correlating MGMT expression with the clinical response of a high-grade spinal cord astrocytoma treated using TMZ.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Astrocytoma / drug therapy. Astrocytoma / metabolism. Dacarbazine / analogs & derivatives. O(6)-Methylguanine-DNA Methyltransferase / metabolism. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / metabolism

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  • (PMID = 17542512.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
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23. Mendiratta-Lala M, Kader Ellika S, Gutierrez JA, Patel SC, Jain R: Spinal cord pilomyxoid astrocytoma: an unusual tumor. J Neuroimaging; 2007 Oct;17(4):371-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord pilomyxoid astrocytoma: an unusual tumor.
  • We present the imaging findings of a case of spinal pilomyxoid astrocytoma in a 29-year-old woman with history of neck and back pain and weakness of bilateral upper extremities.
  • Spinal pilomyxoid astrocytoma is rare with only three reported cases in pediatric population in the literature.
  • This report illustrates the MR findings of an unusual case of intradural extramedullary spinal pilomyxoid tumor in an adult patient.
  • [MeSH-major] Astrocytoma / diagnosis. Magnetic Resonance Imaging. Myxoma / diagnosis. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 17894633.001).
  • [ISSN] 1051-2284
  • [Journal-full-title] Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • [ISO-abbreviation] J Neuroimaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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24. Magilner D: Localized cervical pruritus as the presenting symptom of a spinal cord tumor. Pediatr Emerg Care; 2006 Oct;22(10):746-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Localized cervical pruritus as the presenting symptom of a spinal cord tumor.
  • Intramedullary spinal cord tumors are rare in children.
  • We present an unusual case of a 6-year-old girl who had an intramedullary cervical spinal cord astrocytoma.
  • Pruritus as a symptom of spinal cord pathology is discussed.
  • [MeSH-major] Astrocytoma / diagnosis. Neck Pain / etiology. Pruritus / etiology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 17047476.001).
  • [ISSN] 1535-1815
  • [Journal-full-title] Pediatric emergency care
  • [ISO-abbreviation] Pediatr Emerg Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. O'Brien M, Curtis C, D'Hemecourt P, Proctor M: Case report: a case of persistent back pain and constipation in a 5-year-old boy. Phys Sportsmed; 2009 Apr;37(1):133-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pediatric intramedullary spinal cord tumors are rare and account for 3% to 6% of all central nervous system tumors.
  • We report a case of an intramedullary spinal cord astrocytoma in a 5-year-old boy with nonspecific mid-back pain for 3 months.
  • An urgent magnetic resonance imaging showed an intramedullary tumor in the mid-thoracic cord, confirmed by surgical excision.
  • Associated findings, including nocturnal pain and neurological symptoms may indicate a more serious underlying pathology such as a tumor.
  • [MeSH-major] Astrocytoma / complications. Back Pain / etiology. Constipation / etiology. Spinal Cord Neoplasms / complications

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  • (PMID = 20048499.001).
  • [ISSN] 0091-3847
  • [Journal-full-title] The Physician and sportsmedicine
  • [ISO-abbreviation] Phys Sportsmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Aloisio F, Levine JM, Edwards JF: Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. J Vet Diagn Invest; 2008 Nov;20(6):836-8
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  • [Title] Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma.
  • A gemistocytic astrocytoma is described in the spinal cord of a 3-year-old, spayed, female, Domestic Shorthair cat.
  • Only 1 p53-positive cell was found in the normal spinal cord.
  • The increased expression of p53 in the neoplasm was suggestive of an abnormal biological behavior of the p53 protein and its possible involvement in the neoplastic process of feline astrocytoma.
  • [MeSH-major] Astrocytoma / veterinary. Cat Diseases / pathology. Spinal Cord Neoplasms / veterinary
  • [MeSH-minor] Animals. Astrocytes / pathology. Cats. Euthanasia. Female. Spinal Cord / pathology

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  • (PMID = 18987242.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Hamir AN, Picton R, Blythe LL, Heidel JR: Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor). Vet Pathol; 2008 Nov;45(6):949-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor).
  • Described are clinical signs and pathologic and immunohistochemical findings in an adult female raccoon (Procyon lotor) with an astrocytoma that involved medulla, cervical spinal cord, and roots of the cervical spinal nerves.
  • This appears to be the only reported case of astrocytoma that involved multiple anatomic sites in the central nervous system of this raccoon.
  • [MeSH-major] Astrocytoma / veterinary. Central Nervous System Neoplasms / veterinary. Medulla Oblongata / pathology. Raccoons. Spinal Cord / pathology. Spinal Nerves / pathology

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  • (PMID = 18984803.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Abel TJ, Chowdhary A, Thapa M, Rutledge JC, Geyer JR, Ojemann J, Avellino AM: Spinal cord pilocytic astrocytoma with leptomeningeal dissemination to the brain. Case report and review of the literature. J Neurosurg; 2006 Dec;105(6 Suppl):508-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord pilocytic astrocytoma with leptomeningeal dissemination to the brain. Case report and review of the literature.
  • Leptomeningeal dissemination of low-grade spinal cord gliomas is an uncommon event.
  • The authors report a unique case of leptomeningeal dissemination of a spinal cord pilocytic astrocytoma (PCA) to the intracranial cerebral subarachnoid spaces in a child.
  • An intradural intramedullary spinal cord tumor was identified, and the lesion was subtotally resected and diagnosed by the pathology department to be a PCA.
  • Subsequently, the patient had recurrences of the intradural intramedullary tumor at 6 months and 2 years after his original presentation.
  • He underwent a repeated resection of the recurrent tumor and fenestration of an associated syrinx on both occasions.
  • The pathological characteristics of the reresected tumor remained consistent with those of a PCA.
  • The patient then underwent chemotherapy, and total spine magnetic resonance (MR) imaging 2 months later demonstrated stability in the size of the spinal cord tumor and a decrease in the associated syrinx.
  • However, an MR image of the head demonstrated two new areas of supratentorial subarachnoid leptomeningeal spread of the primary spinal cord tumor at the 2-month follow-up examination.
  • This case illustrates a unique instance of supratentorial leptomeningeal dissemination of an intramedullary spinal cord PCA in a child.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / secondary. Meningeal Neoplasms / secondary. Spinal Cord Neoplasms / pathology


29. Rodriguez y Baena R, Di Ieva A, Colombo P, Collini P, Navarria P, Scorsetti M, Gaetani P, Santoro A: Intramedullary astrocytoma with granular cell differentiation. Neurosurg Rev; 2007 Oct;30(4):339-43; discussion 343

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary astrocytoma with granular cell differentiation.
  • Granular cell astrocytomas are uncommon tumors of the central nervous system (CNS) of which no cases have been documented in the spinal cord.
  • This variant of glioma should not be confused with benign granular cell tumor which, although rare, has been well characterized in the spinal cord.
  • We describe here the clinical, pathological, and radiological features of such an astrocytoma arising within the spinal cord at the dorsal level.
  • Magnetic resonance imaging (MRI) studies showed a 2-cm contrast-enhanced mass in the spinal cord at T6-T7, which had the appearance of an astrocytoma.
  • At surgery, the tumor was found to be infiltrating a posterior column with no dural attachment.
  • The histological diagnosis was astrocytoma with granular cell differentiation.
  • In addition to documenting a unique example of intramedullary granular cell astrocytoma, we review the literature to investigate differences from other tumors with granular changes described in the spinal cord.
  • [MeSH-major] Astrocytoma / diagnostic imaging. Astrocytoma / pathology. Spinal Cord Neoplasms / diagnostic imaging. Spinal Cord Neoplasms / pathology

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  • [Cites] Br J Neurosurg. 1997 Jun;11(3):257-9 [9231019.001]
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  • (PMID = 17483971.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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30. Milano MT, Johnson MD, Sul J, Mohile NA, Korones DN, Okunieff P, Walter KA: Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. J Neurooncol; 2010 May;98(1):83-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study.
  • To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE).
  • Smaller tumor size also improved survival.
  • Smaller tumor size did not confer a survival benefit.
  • Patients with resected grade 2 spinal cord glioma who did not receive radiotherapy fared well with respect to OS and CSS.
  • For patients with spinal cord glioma, the variables of histology, grade, age and undergoing resection are significant predictors of outcome.
  • [MeSH-major] Glioma / classification. Glioma / epidemiology. SEER Program. Spinal Cord Neoplasms / classification. Spinal Cord Neoplasms / epidemiology

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  • (PMID = 19898743.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Galarza M, Peretta P, Gazzeri R, Cinalli G, Forni M, Morra I, Ragazzi P, Sandri S: Spinal cord gliomas and hydrocephalus: utility of neuroendoscopy. Minim Invasive Neurosurg; 2006 Dec;49(6):347-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord gliomas and hydrocephalus: utility of neuroendoscopy.
  • OBJECTIVE: The aim of this study is to report on the role of neuroendoscopy during the management of hydrocephalus that led to the diagnosis of intracranial tumoral dissemination and the subsequent finding of a spinal cord glioma.
  • METHODS AND RESULTS: We present two children each with an intramedullary astrocytoma that presented initially with hydrocephalus without spinal cord symptoms.
  • The diagnosis of a cervical and a lower thoracic intramedullary tumor was made soon after on magnetic resonance imaging.
  • CONCLUSIONS: Spinal cord MRI with contrast should be considered initially in selected cases of hydrocephalus without evident diagnosis.
  • The intraoperative diagnosis of gliomatous dissemination and secondary hydrocephalus due to unrecognized spinal cord gliomas was possible, in our experience, with the routine use of the neuroendoscope.
  • [MeSH-major] Astrocytoma / surgery. Endoscopy. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Child, Preschool. Craniotomy. Humans. Hydrocephalus / diagnosis. Hydrocephalus / pathology. Hydrocephalus / surgery. Infant. Magnetic Resonance Imaging, Cine. Male. Meninges / pathology. Neoplasm Invasiveness / pathology. Pons / pathology. Spinal Cord / pathology. Spinal Cord / surgery. Third Ventricle / pathology. Tomography, X-Ray Computed. Ventriculoperitoneal Shunt. Ventriculostomy

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  • (PMID = 17323261.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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32. White JB, Miller GM, Layton KF, Krauss WE: Nonenhancing tumors of the spinal cord. J Neurosurg Spine; 2007 Oct;7(4):403-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonenhancing tumors of the spinal cord.
  • In the brain, the presence or absence of gadolinium enhancement is often an indicator of tumor invasiveness and/or grade.
  • In the spinal cord, however, contrast enhancement has been shown in all tumor types, regardless of grade.
  • In this study the authors explore the incidence of nonenhancing tumors of the spinal cord and the clinical course of patients with these lesions.
  • METHODS: A retrospective analysis was conducted in which investigators examined the patterns of enhancement of histologically proven intramedullary spinal cord tumors that had been evaluated at the Mayo Clinic between 1998 and 2002.
  • Histologically, a majority of tumors were astrocytomas (eight low-grade and two high-grade lesions); one tumor was a subependymoma.
  • Tumors spanned from two to seven levels and were located throughout the spinal cord (four cervical, three cervicothoracic, one thoracic, and three thoracolumbar).
  • CONCLUSIONS: A number of intramedullary spinal cord tumors will not enhance after addition of contrast agents.
  • The absence of enhancement does not imply the absence of tumor.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / radiography. Glioma, Subependymal / pathology. Glioma, Subependymal / radiography. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiography

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  • (PMID = 17933314.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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33. Crabtree KL, Arnold PM: Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously. Pediatr Neurosurg; 2010;46(1):66-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously.
  • Pilocytic astrocytoma (PA) is a slow-growing, well-circumscribed grade I glioma generally considered benign, with a low recurrence rate and an excellent prognosis following complete surgical resection.
  • Fifteen months after spinal PA resection, the patient is doing well, has regained the ability to stand independently, and has no evidence of any new or enlarging lesions.
  • To our knowledge, this is the longest time reported from initial tumor resection of leptomeningeal dissemination to the distal spinal cord.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Meningeal Neoplasms / secondary. Neoplasm Seeding. Spinal Cord Neoplasms / secondary

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20516744.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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34. Wilson PE, Oleszek JL, Clayton GH: Pediatric spinal cord tumors and masses. J Spinal Cord Med; 2007;30 Suppl 1:S15-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric spinal cord tumors and masses.
  • BACKGROUND/OBJECTIVE: Spinal cord tumors are a relatively rare diagnosis, accounting for 1% to 10% of all pediatric central nervous system tumors.
  • SUBJECTS: Thirty-five children with a final diagnosis of spinal cord tumor or mass, excluding dysraphism.
  • RESULTS: Neurodevelopmental tumors (dermoid tumors, epidermoid tumors, and teratomas) were the most common tumor type (31%), followed by astrocytomas (29%) and neuroblastomas (14%).
  • Mean age at diagnosis was 6.6 years (SD = 5.5 y) and did not vary significantly by tumor type except for children with neuroblastoma (mean = 0.4 y, SD = 0.5 y).
  • More boys (57%) were identified in the series than girls (43%); however, there was no association between tumor type and sex.
  • CONCLUSIONS: This study corroborates other studies indicating that intramedullary tumors are the predominant form of pediatric spinal cord tumor.
  • Although, in general, spinal cord tumors are relatively rare, this preliminary study supports the need to further evaluate associations between tumor type, presenting symptoms, treatment, and functional outcome in children with spinal cord tumors.
  • [MeSH-major] Pediatrics. Spinal Cord Neoplasms / epidemiology
  • [MeSH-minor] Astrocytoma. Child. Child, Preschool. Female. Humans. Infant. Male. Meningioma. Neurilemmoma. Neuroblastoma. Retrospective Studies. Risk Factors. Sex Factors

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  • (PMID = 17874681.001).
  • [ISSN] 1079-0268
  • [Journal-full-title] The journal of spinal cord medicine
  • [ISO-abbreviation] J Spinal Cord Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2031985
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35. Schittenhelm J, Ebner FH, Tatagiba M, Wolff M, Nägele T, Meyermann R, Mittelbronn M: Holocord pilocytic astrocytoma--case report and review of the literature. Clin Neurol Neurosurg; 2009 Feb;111(2):203-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Holocord pilocytic astrocytoma--case report and review of the literature.
  • Intramedullary glial neoplasms affecting the entire cord from the cervicomedullary junction to the conus are termed "holocord tumors" and those diagnosed as pilocytic astrocytoma are rare.
  • Herein, we present a 13-year-old girl with a tumor extending from the cervicomedullary junction to the conus which was partially resected in a four-stage approach.
  • Histopathological examination of all specimens resulted in diagnosis of a pilocytic astrocytoma.
  • Residual parts of the tumor showed progress making additional surgery necessary.
  • [MeSH-major] Astrocytoma / surgery. Spinal Cord / pathology. Spinal Cord Neoplasms / surgery

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  • (PMID = 18980798.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 38
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36. Andrychowski J, Taraszewska A, Czernicki Z, Jurkiewicz J, Netczuk T, Dabrowski P: Ten years observation and treatment of multifocal pilocytic astrocytoma. Folia Neuropathol; 2009;47(4):362-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ten years observation and treatment of multifocal pilocytic astrocytoma.
  • Pilocytic astrocytoma (PA) usually occurs in younger patients.
  • It is a benign, generally well-delineated, WHO grade I tumour with favorable prognosis, which makes it different from diffuse astrocytomas, classified as higher grades of malignancy.
  • A case study of PA was presented in a young female patient, observed and treated at the Neurosurgical Department for the period of 10 years, during which time she had frequent surgical procedures due to recurrence and dissemination of the tumour.
  • Neuroradiological study revealed cerebral tumour in the right temporal lobe, then the first temporal lobe surgery followed by re-operation and radiotherapy was performed.
  • After 5 years local recurrence of the tumour appeared in the right temporal region.
  • The patient was operated and the tumour was totally removed.
  • Initially, the histopathological diagnosis of ganglioglioma was suggested for primary tumour, finally the diagnosis of pilocytic astrocytoma for both recurrent and primary tumour was established.
  • Consecutive MRI studies revealed a spinal canal tumours localized at the thoracic level and next at sacral level.
  • The spinal tumour was surgically treated in both locations; the last operation was done 10 years after surgery of the primary temporal lobe tumour.
  • Histopathological examinations of the excised foci from spinal canal revealed neoplasm consistent with WHO grade I pilocytic astrocytoma.
  • The presented case indicates that despite the spread of the neoplastic process, a histopathologically benign tumour (WHO I grade) allows for long-term survival and observation period.
  • Unfortunately, multifocal tumour involving midline structures causes major neurological symptoms and deficits.

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  • (PMID = 20054789.001).
  • [ISSN] 1509-572X
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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37. Chamberlain MC: Temozolomide for recurrent low-grade spinal cord gliomas in adults. Cancer; 2008 Sep 1;113(5):1019-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temozolomide for recurrent low-grade spinal cord gliomas in adults.
  • BACKGROUND: There is no standard therapy for surgery- and radiotherapy-resistant, recurrent, low-grade spinal cord gliomas.
  • Therefore, a retrospective study of temozolomide (TMZ) in adults with recurrent low-grade spinal cord gliomas with a primary objective of determining progression-free survival (PFS) was performed.
  • METHODS: Twenty-two patients (11 men and 11 women) aged 20 years to 55 years (median, 35 years) with recurrent spinal cord gliomas (World Health Organization grade 2 astrocytoma in 19 patients and oligoastrocytoma in 3 patients) were treated.
  • Time to tumor progression ranged from 2 months to 28 months (median, 14.5 months).
  • CONCLUSIONS: TMZ demonstrated modest efficacy with acceptable toxicity in this cohort of adult patients with recurrent low-grade spinal cord gliomas.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Dacarbazine / analogs & derivatives. Glioma / drug therapy. Spinal Cord Neoplasms / drug therapy

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  • [Copyright] (c) 2008 American Cancer Society.
  • (PMID = 18615600.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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38. Anan M, Inoue R, Ishii K, Abe T, Fujiki M, Kobayashi H, Goya T, Nakazato Y: A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord. Hum Pathol; 2009 Jun;40(6):898-901

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord.
  • This report presents the first case of a rosette-forming glioneuronal tumors arising from the spinal cord.
  • Magnetic resonance imaging demonstrated a mass in the cervicothoracic spinal cord that suggested an intramedullary spinal tumor.
  • A total gross resection of the tumor was performed.
  • As is typical of rosette-forming glioneuronal tumors of the fourth ventricle, this spinal cord example manifested neurocytic and astrocytic components.
  • The astrocytic component showed characteristic features of a pilocytic astrocytoma, as is often the case in the fourth ventricle examples.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Astrocytoma / pathology. Female. Humans. Rosette Formation

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  • [CommentIn] Hum Pathol. 2009 Oct;40(10):1510; author reply 1510 [19616823.001]
  • (PMID = 19269010.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Ogden AT, Feldstein NA, McCormick PC: Anterior approach to cervical intramedullary pilocytic astrocytoma. Case report. J Neurosurg Spine; 2008 Sep;9(3):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anterior approach to cervical intramedullary pilocytic astrocytoma. Case report.
  • Although there has been considerable experience with anterior approaches to ventral intradural, extramedullary, and pial-based spinal lesions, there is no information in the literature regarding the safety and feasibility of the resection of an intramedullary tumor via an anterior approach.
  • The authors report on the gross-total resection of an intramedullary cervical pilocytic astrocytoma via a C-7 corpectomy and anterior myelotomy.
  • [MeSH-major] Astrocytoma / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 18928220.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Brinar M, Rados M, Habek M, Poser CM: Enlargement of the spinal cord: inflammation or neoplasm? Clin Neurol Neurosurg; 2006 Mar;108(3):284-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Enlargement of the spinal cord: inflammation or neoplasm?
  • Intramedullary spinal tumours are uncommon lesions that can cause significant difficulties in the differential diagnosis between inflammatory diseases such as multiple sclerosis and acute disseminated encephalomyelitis, and vascular malformations or neoplasms.
  • We report five cases in which the history and the clinical symptoms suggested an inflammatory process of the spinal cord but the MRI characteristics were those of neoplastic lesions.
  • [MeSH-major] Astrocytoma / diagnosis. Encephalomyelitis, Acute Disseminated / diagnosis. Multiple Sclerosis / diagnosis. Myelitis / etiology. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis

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  • [CommentIn] Clin Neurol Neurosurg. 2007 Dec;109(10):931-3 [17868981.001]
  • [CommentIn] Clin Neurol Neurosurg. 2006 Dec;108(8):811-2 [16793201.001]
  • (PMID = 16376015.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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41. Mueller-Mang C: [Imaging of demyelinating and neoplastic diseases of the spinal cord]. Radiologe; 2010 Dec;50(12):1073-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Imaging of demyelinating and neoplastic diseases of the spinal cord].
  • Demyelinating as well as neoplastic spinal cord diseases can cause paresthesia, progressive sensomotoric deficits and bowel and bladder dysfunction.
  • Although intramedullary neoplasms are far less common than demyelinating spinal cord diseases, radiologists should be familiar with the three most common entities, astrocytoma, ependymoma and hemangioblastoma, which represent over 70% of all spinal cord neoplasms.
  • An early diagnosis and therapy is essential with neoplastic and demyelinating spinal cord diseases to hold residual neurological deficits as low as possible.
  • [MeSH-major] Demyelinating Diseases / diagnosis. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Spinal Cord Diseases / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Astrocytoma / diagnosis. Ependymoma / diagnosis. HIV Infections / diagnosis. Hemangioblastoma / diagnosis. Humans. Multiple Sclerosis / diagnosis. Myelitis, Transverse / diagnosis. Sensitivity and Specificity. Spinal Cord / pathology

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  • (PMID = 20967416.001).
  • [ISSN] 1432-2102
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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42. Khongkhatithum C, Visudtibhan A, Chiemchanya S, Visudhiphan P, Sanvivad P, Larbcharoensub N, Phudhicharoenrat S: Multicentric anaplastic astrocytoma in a child. J Clin Neurosci; 2007 Feb;14(2):176-9
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  • [Title] Multicentric anaplastic astrocytoma in a child.
  • We report a rare case of anaplastic astrocytoma with multicentric central nervous system lesions in a 10-year-old girl presenting with a 1-month history of progressive headache and paraparesis.
  • Cranial and spinal magnetic resonance imaging revealed multiple tumour foci within the suprasellar region, cerebellar hemisphere, cervical and thoracic cords.
  • After an uneventful laminectomy and excision of the tumour at the T8-9 level, a significant improvement of motor function was observed.
  • The histological diagnosis was anaplastic astrocytoma based on the WHO classification.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 17161293.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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43. Matsuyama Y, Sakai Y, Katayama Y, Imagama S, Ito Z, Wakao N, Sato K, Kamiya M, Yukawa Y, Kanemura T, Yanase M, Ishiguro N: Surgical results of intramedullary spinal cord tumor with spinal cord monitoring to guide extent of resection. J Neurosurg Spine; 2009 May;10(5):404-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical results of intramedullary spinal cord tumor with spinal cord monitoring to guide extent of resection.
  • OBJECT: The authors investigated the outcome of intramedullary spinal cord tumor surgery, focusing on the effect of preoperative neurological status on postoperative mobility and the extent of tumor excision guided by intraoperative spinal cord monitoring prospectively.
  • METHODS: Intramedullary spinal cord tumor surgery was performed in 131 patients between 1997 and 2007.
  • The tumor types included astrocytoma (12 cases), ependymoma (46 cases), hemangioblastoma (16 cases), cavernous hemangioma (17 cases), and others (15 cases overall: gangliocytoma, 1; germ cell tumor, 1; lymphoma, 3; neurinoma, 1; meningioma, 1; oligodendroglioma, 1; sarcoidosis, 2; glioma, 1; and unknown, 4).
  • However, the rate of postoperative deterioration was 31.5%, which is relatively high, and patients should be fully informed of this concern prior to intramedullary spinal cord tumor surgery.
  • [MeSH-major] Monitoring, Intraoperative / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / surgery. Child. Ependymoma / surgery. Female. Follow-Up Studies. Hemangioblastoma / surgery. Hemangioma, Cavernous / surgery. Humans. Male. Middle Aged. Postoperative Complications. Prognosis. Prospective Studies. Walking

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  • (PMID = 19442001.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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44. Colnat-Coulbois S, Klein O, Braun M, Thouvenot P, Marchal JC: Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. Neurosurgery; 2010 May;66(5):E1023-4; discussion E1024
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  • [Title] Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report.
  • OBJECTIVE: We report a case of cystic spinal cord pilocytic astrocytoma treated with surgical resection and 2 intracavitary injections of rhenium.
  • Spinal cord magnetic resonance showed a large, cystic, intramedullary tumor extending from T9 to T12.
  • Pathological examination allowed the diagnosis of pilocytic astrocytoma.
  • CONCLUSION: Interstitial intracavitary rhenium brachytherapy of recurrent spinal cord cystic astrocytomas achieved excellent stabilization of the cyst with minor side-effects and dramatic improvement of neurological deficits.
  • [MeSH-major] Astrocytoma / radiotherapy. Brachytherapy / methods. Radioisotopes / therapeutic use. Rhenium / therapeutic use. Spinal Cord Neoplasms / radiotherapy

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  • (PMID = 20404673.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radioisotopes; 7440-15-5 / Rhenium
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45. Tendulkar RD, Pai Panandiker AS, Wu S, Kun LE, Broniscer A, Sanford RA, Merchant TE: Irradiation of pediatric high-grade spinal cord tumors. Int J Radiat Oncol Biol Phys; 2010 Dec 01;78(5):1451-6
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  • [Title] Irradiation of pediatric high-grade spinal cord tumors.
  • PURPOSE: To report the outcome using radiation therapy (RT) for pediatric patients with high-grade spinal cord tumors.
  • METHODS AND MATERIALS: A retrospective chart review was conducted that included 17 children with high-grade spinal cord tumors treated with RT at St. Jude Children's Research Hospital between 1981 and 2007.
  • The tumor diagnosis was glioblastoma multiforme (n = 7), anaplastic astrocytoma (n = 8), or anaplastic oligodendroglioma (n = 2).
  • Local tumor progression at 12 months (79% vs. 30%, p = 0.02) and median survival (13.1 vs. 27.2 months, p = 0.09) were worse for patients with glioblastoma multiforme compared with anaplastic astrocytoma or oligodendroglioma.
  • CONCLUSIONS: High-grade spinal cord primary tumors in children have a poor prognosis.
  • [MeSH-major] Astrocytoma / radiotherapy. Oligodendroglioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20346593.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Titlic M, Tonkic A, Jukic I, Buca A, Punda A: Leptomeningeal metastases of an astrocytoma of the conus medullaris: a case report. Acta Neurol Belg; 2008 Dec;108(4):170-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leptomeningeal metastases of an astrocytoma of the conus medullaris: a case report.
  • We describe a case of spinal leptomeningeal metastases of an astrocytoma of the conus medullaris that presented with quadriplegia.
  • The patient was a 50-year-old woman with a previously treated astrocytoma of the conus medullaris and a spinal cord metastasis at the Th2-L level.
  • Magnetic resonance imaging of the cervical spine showed an intradural extramedullary metastatic tumor deposit at the C3-C6 level.
  • Spinal leptomeningeal metastases need to be suspected in patients with a history of intramedullary astrocytoma.
  • [MeSH-major] Astrocytoma / secondary. Meningeal Neoplasms / secondary. Spinal Cord Neoplasms / pathology

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  • (PMID = 19239049.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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47. Gill M, Pathak HC, Madan R, Bhattacharya S, Choudhary GS: Primary spinal pleomorphic xanthoastrocytoma. Neurol India; 2010 Sep-Oct;58(5):771-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal pleomorphic xanthoastrocytoma.
  • Pleomorphic xanthochromic astrocytoma primarily of the spinal cord is a rare entity.
  • [MeSH-major] Astrocytoma / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Complex and Mixed. Spinal Cord Neoplasms / pathology

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  • (PMID = 21045509.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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48. Zorlu F, Selek U, Akyuz C, Ozturk A, Soylemezoglu F, Akalan N: Spinal seeding of a pilocytic astrocytoma following multiple subtotal resections. Pediatr Neurosurg; 2005 Sep-Oct;41(5):248-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal seeding of a pilocytic astrocytoma following multiple subtotal resections.
  • We report the case of a 4-year-old girl presenting with spinal and leptomeningeal dissemination following several subtotal resections of cerebellar pilocytic astrocytomas.
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Meningeal Neoplasms / secondary. Neoplasm Seeding. Neurosurgical Procedures / adverse effects. Spinal Cord Neoplasms / secondary

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 16195677.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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49. Kilinçer C, Oztürk L, Hamamcioglu MK, Altunrende E, Cobanoglu S: An upper thoracic spinal cord tumor presenting as hemifacial hyperhidrosis. Surg Neurol; 2007 Oct;68(4):461-3; discussion 463
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An upper thoracic spinal cord tumor presenting as hemifacial hyperhidrosis.
  • BACKGROUND: Hyperhidrosis as the sole presenting symptom of an upper thoracic intramedullary tumor has never been reported in the English literature.
  • The MRI revealed a large spinal cord tumor at the T1-T2 levels.
  • The patient underwent total excision of the intramedullary tumor via a posterior myelotomy.
  • The histopathological diagnosis was low-grade astrocytoma.
  • [MeSH-major] Astrocytoma / diagnosis. Hyperhidrosis / etiology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 17905075.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Hébert-Blouin MN, Bishop AT, Shin AY, Wetmore C, Spinner RJ: Tardy spinal cord tumor following avulsive brachial plexus injury: coincidental or causal? World Neurosurg; 2010 Aug-Sep;74(2-3):368-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tardy spinal cord tumor following avulsive brachial plexus injury: coincidental or causal?
  • RESULTS: Magnetic resonance imaging and computed tomography myelogram revealed spinal cord herniation at the same level of the previous nerve root avulsions.
  • Surgical open biopsy demonstrated a spinal cord anaplastic astrocytoma.
  • The probable coincidental versus possible causal interrelationship of these two processes (BPI and spinal cord tumor) is discussed, but no conclusions can be reached.
  • [MeSH-major] Astrocytoma / etiology. Brachial Plexus / injuries. Spinal Cord Neoplasms / etiology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] World Neurosurg. 2010 Aug-Sep;74(2-3):275-6 [21492559.001]
  • (PMID = 21492572.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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51. Nakamura M, Chiba K, Matsumoto M, Ikeda E, Toyama Y: Pleomorphic xanthoastrocytoma of the spinal cord. Case report. J Neurosurg Spine; 2006 Jul;5(1):72-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic xanthoastrocytoma of the spinal cord. Case report.
  • The authors present clinical, radiological, and pathological features in a patient with a pleomorphic xanthoastrocytoma (PXA) of the spinal cord.
  • To their knowledge, this is only the second report of a spinal cord PXA.
  • [MeSH-major] Astrocytoma / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 16850961.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Harrop JS, Ganju A, Groff M, Bilsky M: Primary intramedullary tumors of the spinal cord. Spine (Phila Pa 1976); 2009 Oct 15;34(22 Suppl):S69-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intramedullary tumors of the spinal cord.
  • OBJECTIVE: To define optimal clinical care for primary intramedullary spinal cord tumors using a systematic review with expert opinion.
  • METHODS: Focused questions on the treatment of primary intramedullary spinal cord tumors were refined by a panel of spine oncology surgeons, medical and radiation oncologist.
  • The subsequent search resulted in a return of: "spinal cord tumor" (5053), "ependymoma" (580), "astrocytoma" (420), and "glioma" (235) articles.
  • Seventeen articles referenced timing of surgical intervention and symptomatology for intramedullary spinal cord tumors.
  • One hundred fifty-eight chemotherapy and 183 radiation therapy articles for intramedullary spinal cord tumors were reviewed.
  • However, this must be taken in the context of the underlying tumor histology.
  • [MeSH-major] Glioma / radiotherapy. Glioma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery

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  • (PMID = 19829279.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 75
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53. Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M, Toyama Y, Chiba K: Surgical treatment of intramedullary spinal cord tumors: prognosis and complications. Spinal Cord; 2008 Apr;46(4):282-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of intramedullary spinal cord tumors: prognosis and complications.
  • OBJECTIVE: To evaluate our recent treatment strategy for intramedullary spinal cord tumors.
  • METHODS: We reviewed 68 cases of intramedullary tumors (ependymoma, 33; astrocytoma, 23; hemangioblastoma, 12), treated surgically between 1994 and 2003.
  • The tumor malignancy grade according to the WHO classification was astrocytoma grade I, 3; grade II, 8 (low-grade: 11 cases); grade III, 10; grade IV, 2 (high-grade: 12 cases).
  • Cordotomy should be considered in patients with a thoracic high-grade astrocytoma.
  • CONCLUSIONS: Predictors of good surgical outcome for intramedullary spinal cord tumors were histological grades of the tumors, surgical margins, and neurological status of the patient before surgery.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 17909556.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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54. Kothbauer KF: Neurosurgical management of intramedullary spinal cord tumors in children. Pediatr Neurosurg; 2007;43(3):222-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurosurgical management of intramedullary spinal cord tumors in children.
  • The majority of intramedullary spinal cord tumors in children are low-grade glial tumors.
  • They become symptomatic with pain, neurologic deficits or spinal deformity.
  • In case of a low-grade tumor or a vascular lesion such as hemangioblastoma or cavernoma, a total or near-total resection is attempted.
  • [MeSH-major] Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Astrocytoma / diagnosis. Astrocytoma / mortality. Astrocytoma / surgery. Child. Disease-Free Survival. Ependymoma / diagnosis. Ependymoma / mortality. Ependymoma / surgery. Follow-Up Studies. Ganglioglioma / diagnosis. Ganglioglioma / mortality. Ganglioglioma / surgery. Hemangioblastoma / diagnosis. Hemangioblastoma / mortality. Hemangioblastoma / surgery. Humans. Magnetic Resonance Imaging. Monitoring, Intraoperative. Postoperative Complications / diagnosis. Postoperative Complications / etiology. Prognosis

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  • (PMID = 17409792.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 98
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55. Marchan EM, Sekula RF Jr, Jannetta PJ, Quigley MR: Long-term survival enhanced by cordectomy in a patient with a spinal glioblastoma multiforme and paraplegia. Case report. J Neurosurg Spine; 2007 Dec;7(6):656-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival enhanced by cordectomy in a patient with a spinal glioblastoma multiforme and paraplegia. Case report.
  • Spinal glioblastomas multiforme (GBMs) are rare lesions of the central nervous system with a prognosis as poor as that of their intracranial counterpart.
  • The authors present a case of a 50-year-old man with a GBM of the spinal cord treated with surgical removal of the mass and cordectomy after the onset of paraplegia.
  • Although intracranial dissemination of spinal GBMs has been reported, this case illustrates the longest reported interval between the occurrence of a spinal GBM and its intracranial dissemination.
  • Thus, cordectomy should be considered as a reasonable alternative in patients with complete loss of neurological function at and below the level where they harbor a malignant spinal cord astrocytoma.
  • [MeSH-major] Glioblastoma / complications. Glioblastoma / surgery. Neurosurgical Procedures. Paraplegia / etiology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Antiviral Agents / therapeutic use. Cerebellar Neoplasms / secondary. Fatal Outcome. Hepatitis C / complications. Hepatitis C / drug therapy. Humans. Interferon-alpha / therapeutic use. Magnetic Resonance Imaging. Male. Middle Aged. Polyethylene Glycols. Recombinant Proteins. Spinal Cord / surgery. Survival Analysis

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  • (PMID = 18074692.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 99210-65-8 / interferon alfa-2b
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56. Vargas MI, Delavelle J, Jlassi H, Rilliet B, Viallon M, Becker CD, Lövblad KO: Clinical applications of diffusion tensor tractography of the spinal cord. Neuroradiology; 2008 Jan;50(1):25-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical applications of diffusion tensor tractography of the spinal cord.
  • The aim of this study was to assess the clinical utility of DTI in patients with diseases of the spinal cord.
  • Preliminary diagnosis of the patients suggested traumatic, tumorous, ischemic or inflammatory lesions of the spinal cord.
  • Diffusion tensor imaging showed a clear displacement and deformation of the white matter tracts at the level of the pathological lesions in the spinal cord.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Image Enhancement. Image Processing, Computer-Assisted. Nerve Fibers / pathology. Spinal Cord / pathology. Spinal Cord Diseases / diagnosis
  • [MeSH-minor] Adolescent. Adult. Anisotropy. Astrocytoma / diagnosis. Cervical Vertebrae. Ependymoma / diagnosis. Female. Humans. Intervertebral Disc Displacement. Male. Middle Aged. Multiple Myeloma / diagnosis. Neuromyelitis Optica / diagnosis. Spinal Cord Injuries / diagnosis. Spinal Cord Ischemia / diagnosis. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / secondary

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  • [Cites] AJNR Am J Neuroradiol. 2006 Jan;27(1):214-6 [16418387.001]
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  • (PMID = 17909776.001).
  • [ISSN] 1432-1920
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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57. Marinovic T, Grahovac G, Habek M, Lambasa S, Tomac D: Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient. Clin Neuropathol; 2009 May-Jun;28(3):173-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient.
  • We report a patient who had pilocytic astrocytoma in the cerebellum and ependymoma in the cauda equina region, occurring simultaneously.
  • The suggested mechanism of this association is that primitive multipotent cells might have been displaced in the different CNS areas and developed in different tumor cells.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Ependymoma / pathology. Neoplasms, Multiple Primary / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 19537133.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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58. Grau E, Balaguer J, Canete A, Martinez F, Orellana C, Oltra S, Hernandez M, Castel V: Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. J Neurooncol; 2009 Jun;93(2):175-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma.
  • Astrocytic neoplasms are genetically heterogeneous; however a low frequency of genomic changes has been found in juvenile pilocytic astrocytoma (PA) in molecular studies.
  • We studied the subtelomeric regions of 19 primary astrocytoma tumors.
  • Our results indicate that the chromosomal and genetic aberrations in PXAs differed from those typically associated with the diffusely infiltrating astrocytic and oligodendroglial gliomas.
  • [MeSH-major] Astrocytoma / genetics. Chromosomal Instability / genetics. Glioma / genetics. Telomere / genetics
  • [MeSH-minor] Brain Neoplasms / genetics. Child. Chromosome Aberrations. DNA, Neoplasm / genetics. DNA, Neoplasm / isolation & purification. Female. Humans. Loss of Heterozygosity. Male. Oligodendroglioma / genetics. Oligodendroglioma / pathology. Sequence Deletion. Spinal Cord Neoplasms / genetics

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  • (PMID = 19099200.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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59. Zorlu F, Ozyigit G, Gurkaynak M, Soylemezoglu F, Akyol F, Lale Atahan I: Postoperative radiotherapy results in primary spinal cord astrocytomas. Radiother Oncol; 2005 Jan;74(1):45-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postoperative radiotherapy results in primary spinal cord astrocytomas.
  • BACKGROUND AND PURPOSE: We retrospectively evaluated the therapeutic outcomes of patients with primary spinal cord astrocytomas treated with conventional radiotherapy at our institute.
  • PATIENTS AND METHODS: Between May 1975 and December 1997, 26 patients with histologically proven spinal cord astrocytomas were treated with conventional radiotherapy, and twenty-four eligible patients were evaluated.
  • Patients were treated with 1-2 Gy daily fractions, and given to a median total dose of 49.5 Gy (range 35-60 Gy) external radiotherapy to primary tumor.
  • [MeSH-major] Astrocytoma / radiotherapy. Spinal Cord Neoplasms / radiotherapy

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  • (PMID = 15683668.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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60. Tobias ME, McGirt MJ, Chaichana KL, Goldstein IM, Kothbauer KF, Epstein F, Jallo GI: Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst; 2008 Feb;24(2):219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of long intramedullary spinal cord tumors.
  • OBJECT: Spinal cord tumors represent approximately 10-20% of primary central nervous system tumors.
  • MATERIALS AND METHODS: We retrospectively reviewed all patients undergoing surgical resection of longitudinally extensive intramedullary spinal cord tumors involving the majority of the spinal cord between 1990 and 2002.
  • Pathology revealed astrocytoma in six cases (two pilocytic, four grade II), gangliogliomas in four cases, oligodendroglioma in two cases (one anaplastic), and lipoma in one case.
  • One (8%) patient died from progression of anaplastic oligodendroglioma, and two (15%) underwent reoperation for recurrent tumor (ganglioglioma, grade II astrocytoma).
  • Five (38%) patients required fusion for progressive spinal deformity.
  • CONCLUSION: Gross total resection of holocord and longitudinally extensive intramedullary spinal cord tumors can be achieved with preservation of long-term neurological function in many cases.
  • Serial imaging is recommended to guide subsequent resection for tumor recurrence and stabilization of progressive spinal deformity.
  • [MeSH-major] Spinal Cord Neoplasms / surgery

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  • [Cites] Acta Neurochir (Wien). 1984;73(3-4):243-50 [6516922.001]
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  • (PMID = 17639420.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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61. Bapuraj JR, Parmar HA, Blaivas M, Muraszko KM: Imaging features of clear-cell ependymoma of the spinal cord. Pediatr Radiol; 2007 Apr;37(4):384-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging features of clear-cell ependymoma of the spinal cord.
  • MRI demonstrated a large, intramedullary tumor at the level of the conus.
  • The imaging findings were unlike those of a classic ependymoma or astrocytoma.
  • We found three cases of clear-cell ependymoma of the spinal cord reported in the literature.
  • Clear-cell ependymoma of the spinal cord can be resected completely and needs to be recognized for its imaging features, benign course and favorable prognosis.
  • [MeSH-major] Ependymoma / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Child. Contrast Media. Female. Follow-Up Studies. Humans. Lumbar Vertebrae / pathology. Magnetic Resonance Imaging. Spinal Canal / pathology

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  • (PMID = 17279401.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 8
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62. Nakamura M, Chiba K, Ishii K, Ogawa Y, Takaishi H, Matsumoto M, Toyama Y: Surgical outcomes of spinal cord astrocytomas. Spinal Cord; 2006 Dec;44(12):740-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcomes of spinal cord astrocytomas.
  • OBJECTIVES: To analyze prognostic factors for patients with spinal cord astrocytomas.
  • Impacts of the tumor histological grade, the level of the tumor, the types of surgical interventions, and the use of adjuvant radiotherapies on the survival and functional outcomes of 30 patients (18 in low-grade and 12 high-grade malignancy tumors) were analyzed.
  • CONCLUSIONS: The tumor grade and the extent of tumor resection were significant prognostic factors for survival rate.
  • [MeSH-major] Astrocytoma / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 16670687.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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63. Scheinemann K, Bartels U, Huang A, Hawkins C, Kulkarni AV, Bouffet E, Tabori U: Survival and functional outcome of childhood spinal cord low-grade gliomas. Clinical article. J Neurosurg Pediatr; 2009 Sep;4(3):254-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival and functional outcome of childhood spinal cord low-grade gliomas. Clinical article.
  • OBJECT: Intramedullary spinal cord low-grade gliomas (LGGs) are rare CNS neoplasms in pediatric patients, and there is little information on therapy for and outcome of these tumors in this population.
  • To clarify these issues, the authors performed a regional population-based study of spinal cord LGGs in pediatric patients.
  • RESULTS: Spinal cord LGGs in pediatric patients constituted 29 (4.6%) of 635 LGGs.
  • Epidemiological and clinical data in this cohort were different than in patients with other spinal tumors and strikingly similar to data from pediatric patients with intracranial LGGs.
  • Histological testing revealed a Grade I astrocytoma in 86% of tumors.
  • Chemotherapy and radiation therapy showed similar efficacy, achieving sustained tumor control in most patients.
  • CONCLUSIONS: This study provides basic data on the incidence, clinical course, and outcome of spinal cord LGGs in pediatric patients.
  • The similarities between spinal and intracranial LGGs in pediatric patients showing excellent survival but high morbidity suggest that a less aggressive approach may be the preferable treatment option for these patients.
  • [MeSH-major] Glioma / mortality. Glioma / therapy. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / therapy

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  • (PMID = 19772410.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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64. Yang S, Yang X, Hong G: Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors. Spine (Phila Pa 1976); 2009 Nov 15;34(24):2705-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of one hundred seventy-four intramedullary spinal cord tumors.
  • STUDY DESIGN: A retrospective study of microsurgical treatment of intramedullary spinal cord tumors (IMSCT) was conducted.
  • The optimum treatment of those tumors is controversial, with the recent advance, the operation of IMSCTs has became safer and total resection of most those tumor is possible.
  • METHODS: Data from 174 IMSCTs operated on in the last 20 years are analyzed retrospectively by the tumors' anatomic locations, histologic types, symptoms and signs, tumor removal rate, and operative outcomes.
  • RESULTS: In this group ependymoma was the commonest tumor (48.9%), the second most often seen being astrocytoma (35.6%).
  • Total resection of the tumor was possible in 60.9% of patients, subtotal resection in 17.2%, and partial resection in 13.8%.
  • In low grade astrocytoma total resection was possible in 41.1%, subtotal in 35.1%, and partial resection in 23.2%.
  • On long-term follow-up there was improvement in 70.2%, no change in 19.5%, deterioration in 4%, tumor recurrence in 6.9%, with 6.3% of patients dying.
  • CONCLUSION: Most intramedullary spinal cord tumors need operative treatment as early as possible.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery

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  • (PMID = 19910775.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. McGirt MJ, Chaichana KL, Atiba A, Attenello F, Woodworth GF, Jallo GI: Neurological outcome after resection of intramedullary spinal cord tumors in children. Childs Nerv Syst; 2008 Jan;24(1):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurological outcome after resection of intramedullary spinal cord tumors in children.
  • OBJECTIVE: With modern surgical advances, radical resection of pediatric intramedullary spinal cord tumors (IMSCT) can be achieved with preservation of long-term neurological function.
  • Pathology revealed astrocytoma in 12 cases (three pilocytic, four grade II, three grade III, two GBM), gangliogliomas in two, ependymoma in one, and gliosis in one case.
  • Preoperative steroid use (odds ratio, OR [95% confidence interval, CI] = 18.0 [1.24-260.1], p = 0.03) and cystic tumor (OR [95%CI] = 18.0 [1.24-260.1], p = 0.03) predicted neurological improvement after surgery.
  • [MeSH-major] Postoperative Complications / physiopathology. Recovery of Function / physiology. Sensory Deprivation / physiology. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Astrocytoma / complications. Astrocytoma / surgery. Cervical Vertebrae / pathology. Child. Child, Preschool. Ependymoma / complications. Ependymoma / surgery. Female. Ganglioglioma / complications. Ganglioglioma / surgery. Humans. Magnetic Resonance Imaging / methods. Male. Prospective Studies. Quality of Life. Thoracic Vertebrae / pathology. Treatment Outcome

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  • (PMID = 17665203.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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66. Bohner G, Masuhr F, Distl R, Katchanov J, Klingebiel R, Zschenderlein R, von Deimling A, van Landeghem FK: Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. Acta Neuropathol; 2005 Sep;110(3):306-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature.
  • Spinal magnetic resonance imaging showed extended intradural, extramedullary, contrast-enhancing masses with compression of the myelon.
  • Spinal leptomeningeal biopsy revealed a pilocytic astrocytoma WHO grade I.
  • Sequence analysis of tumor protein 53 gene (TP53) revealed a missense mutation in exon 5, and expression of phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) protein was not detected, which may have contributed to astrocytoma development.
  • To our knowledge, this is the first definitive case of pilocytic astrocytoma presenting as PDLG.
  • [MeSH-major] Astrocytoma / pathology. Meningeal Neoplasms / pathology. Meninges / pathology. Neoplasms, Neuroepithelial / pathology. Neoplasms, Unknown Primary / pathology. Subarachnoid Space / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / genetics. Brain / pathology. Brain / physiopathology. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Mutation / genetics. Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 16003541.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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67. Oake C, Borg MF, Hanieh A, Byard RW: Childhood glioblastoma multiforme of the spinal cord. Australas Radiol; 2006 Aug;50(4):360-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood glioblastoma multiforme of the spinal cord.
  • Astrocytoma accounts for more than 50% of all central nervous system tumours diagnosed, with particular prevalence in the 15- to 34-year-old age bracket, rarely arising in younger children.
  • The patient proceeded to biopsy and partial excision of the tumour through laminectomy, histology confirming an anaplastic astrocytoma (glioblastoma multiforme), St Anne Mayo grade 4.
  • This report highlights the efficacy of combined surgery and radiation therapy in the management of spinal cord glioblastoma multiforme in preventing tumour recurrence, with acceptable morbidity.
  • [MeSH-major] Glioblastoma / radiotherapy. Glioblastoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery

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  • (PMID = 16884424.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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68. Yanni DS, Ulkatan S, Deletis V, Barrenechea IJ, Sen C, Perin NI: Utility of neurophysiological monitoring using dorsal column mapping in intramedullary spinal cord surgery. J Neurosurg Spine; 2010 Jun;12(6):623-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Utility of neurophysiological monitoring using dorsal column mapping in intramedullary spinal cord surgery.
  • OBJECT: Intramedullary spinal cord tumors can displace the surrounding neural tissue, causing enlargement and distortion of the normal cord anatomy.
  • Standard anatomical landmarks may be misleading in patients with intramedullary spinal cord tumors due to cord rotation, edema, neovascularization, or local scar formation.
  • METHODS: A group of 10 patients with cervical and thoracic intramedullary spinal cord lesions underwent dorsal column mapping in which a strip electrode was used to define the midline.
  • After the laminectomy and durotomy, a custom-designed multielectrode grid was placed on the exposed dorsal surface of the spinal cord.
  • This strip electrode maps the amplitude gradient of conducted spinal somatosensory evoked potentials elicited by bilateral tibial nerve stimulation.
  • There were 4 ependymomas, 1 subependymoma, 1 gangliocytoma, 1 anaplastic astrocytoma, 1 cavernous malformation, and 2 symptomatic syringes requiring shunting.
  • CONCLUSIONS: Dorsal column mapping is a useful technique for guiding the surgeon in locating the midline for myelotomy in intramedullary spinal cord surgery.
  • [MeSH-major] Evoked Potentials, Somatosensory / physiology. Monitoring, Intraoperative. Spinal Cord / physiopathology. Spinal Cord Neoplasms / surgery

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  • (PMID = 20515347.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Pennant WA, Sciubba DM, Noggle JC, Tyler BM, Tamargo RJ, Jallo GI: Microsurgical removal of intramedullary spinal cord gliomas in a rat spinal cord decreases onset to paresis, an animal model for intramedullary tumor treatment. Childs Nerv Syst; 2008 Aug;24(8):901-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical removal of intramedullary spinal cord gliomas in a rat spinal cord decreases onset to paresis, an animal model for intramedullary tumor treatment.
  • OBJECTIVE: Intramedullary spinal cord tumors (IMSCT) pose significant challenges given their recurrence rate and limited treatment options.
  • Using our previously described rat model of IMSCT, we describe a technique for microsurgical tumor resection and present the functional and histopathological analysis of tumor progression.
  • Group 1 continued with daily assessments using the BBB scale following tumor implantation, but received no further treatment.
  • Group 2 underwent surgical removal of intramedullary tumor on postoperative day five.
  • Hematoxylin-eosin cross-sections confirmed the presence of intramedullary 9L tumor invading the spinal cord in both groups.
  • [MeSH-major] Disease Models, Animal. Gliosarcoma / surgery. Neurosurgical Procedures / methods. Paralysis / prevention & control. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Animals. Astrocytoma / complications. Astrocytoma / pathology. Astrocytoma / surgery. Female. Kaplan-Meier Estimate. Microsurgery / methods. Neoplasms, Experimental. Random Allocation. Rats. Rats, Inbred F344. Reproducibility of Results. Statistics, Nonparametric

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  • (PMID = 18317780.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Germany
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70. Ducreux D, Lepeintre JF, Fillard P, Loureiro C, Tadié M, Lasjaunias P: MR diffusion tensor imaging and fiber tracking in 5 spinal cord astrocytomas. AJNR Am J Neuroradiol; 2006 Jan;27(1):214-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR diffusion tensor imaging and fiber tracking in 5 spinal cord astrocytomas.
  • Spinal cord astrocytomas are rare neoplasms that can result in alteration of the spinal cord structural integrity, which can be assessed by using diffusion tensor imaging methods.
  • Our objective was to visualize the deformation of the posterior spinal cord lemniscal and corticospinal tracts in 5 patients with low-grade astrocytomas compared with 10 healthy volunteers by using 3D fiber-tracking reconstructions.
  • [MeSH-major] Astrocytoma / diagnosis. Diffusion Magnetic Resonance Imaging. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 16418387.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Abdel-Wahab M, Etuk B, Palermo J, Shirato H, Kresl J, Yapicier O, Walker G, Scheithauer BW, Shaw E, Lee C, Curran W, Thomas T, Markoe A: Spinal cord gliomas: A multi-institutional retrospective analysis. Int J Radiat Oncol Biol Phys; 2006 Mar 15;64(4):1060-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord gliomas: A multi-institutional retrospective analysis.
  • PURPOSE: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas.
  • PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01).
  • [MeSH-major] Glioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Astrocytoma / mortality. Astrocytoma / radiotherapy. Astrocytoma / surgery. Child. Child, Preschool. Disease Progression. Ependymoma / mortality. Ependymoma / radiotherapy. Ependymoma / surgery. Female. Humans. Male. Middle Aged. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 16373081.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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72. Marrufo M, Politsky J, Mehta S, Morgan JC, Sethi KD: Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma. Mov Disord; 2007 Sep 15;22(12):1801-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma.
  • He was subsequently diagnosed with a cervical cord anaplastic astrocytoma on MRI.
  • We could not identify previous reports of paroxysmal myoclonus secondary to a spinal cord neoplasm.
  • [MeSH-major] Glioma / complications. Myoclonus / etiology. Spinal Cord Neoplasms / complications

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  • [Copyright] (c) 2007 Movement Disorder Society.
  • (PMID = 17595044.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Hida K, Iwasaki Y, Seki T, Yano S: two-stage operation for resection of spinal cord astrocytomas: technical case report of three cases. Neurosurgery; 2006 Apr;58(4 Suppl 2):ONS-E373; discussion ONS-E373

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] two-stage operation for resection of spinal cord astrocytomas: technical case report of three cases.
  • OBJECTIVE AND IMPORTANCE: Surgery for excision of intramedullary spinal cord tumors without increasing neurological deficit is one of the more difficult operations in spinal surgery.
  • In particular, infiltrating astrocytomas without a clear cleavage between the tumor and normal spinal cord parenchyma are difficult to remove totally without producing additional neurological impairment.
  • CLINICAL PRESENTATION: Three cases of spinal cord astrocytomas were treated using a two-staged method.
  • A thin expanded polytetrafluoroethylene sheet was placed between the dorsal surface of the spinal cord and dura mater to prevent adhesions.
  • Two or 3 weeks after surgery, a second surgery was performed to remove the now exophytic tumor.
  • RESULTS: Magnetic resonance imaging scans showed exophytic extrusion of the tumor in all three cases before the second operation.
  • All three patients remain neurologically stable without evidence of tumor recurrence more than 3 years after surgery.
  • CONCLUSION: A two-stage operation may enhance the surgeon's ability to completely resect extensive low-grade spinal cord astrocytomas and, at the same time preserve neurological function.
  • [MeSH-major] Astrocytoma / surgery. Laminectomy / methods. Spinal Cord Neoplasms / surgery

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  • (PMID = 16575295.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Willems WF, Wieringa JW, Vermeulen RJ, Veenhoven RH: [Limping in toddlers due to disorders of the spine and spinal cord]. Ned Tijdschr Geneeskd; 2007 Oct 20;151(42):2297-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Limping in toddlers due to disorders of the spine and spinal cord].
  • [Transliterated title] Mank lopen bij peuters door afwijkingen aan de wervelkolom en het ruggenmerg.
  • The authors describe three cases of limping in toddlers caused by infrequent spinal diseases.
  • In the last patient, a 19-month-old girl, the limping was caused by an intraspinal intramedullary astrocytoma.
  • She recovered after partial resection of the tumour.
  • [MeSH-major] Astrocytoma / diagnosis. Bone Neoplasms / secondary. Discitis / diagnosis. Neuroblastoma / pathology. Spinal Diseases / diagnosis

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  • (PMID = 18064928.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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75. Do-Dai DD, Brooks MK, Goldkamp A, Erbay S, Bhadelia RA: Magnetic resonance imaging of intramedullary spinal cord lesions: a pictorial review. Curr Probl Diagn Radiol; 2010 Jul-Aug;39(4):160-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging of intramedullary spinal cord lesions: a pictorial review.
  • Magnetic resonance imaging is the current imaging modality of choice in the evaluation of patients presenting with myelopathic symptoms in the search for spinal cord lesions.
  • It is important for the radiologist to recognize and differentiate nonneoplastic from the neoplastic process of the spinal cord as the differentiation of the 2 entities is extremely crucial to the neurosurgeon.
  • This article presents a broad spectrum of benign intramedullary spinal abnormalities including syrinx, contusion, abscess, infarction, myelitis, multiple sclerosis, sarcoid, cavernoma, and arteriovenous malformation.
  • Rare intramedullary neoplasms including dermoid tumor, astrocytoma, ependymoma, hemangioblastoma, lymphoma, ganglioneuroblastoma, and metastases are also illustrated.
  • The potential pitfalls in the differentiation of tumors from nonneoplastic disease of the spinal cord are also elucidated.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Spinal Cord / pathology. Spinal Cord Diseases / diagnosis
  • [MeSH-minor] Female. Humans. Male. Sensitivity and Specificity. Spinal Cord Injuries / diagnosis. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 20510754.001).
  • [ISSN] 1535-6302
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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76. Klase D, Gottschalk S, Reusche E, Hagel C, Goebel E, Tronnier V, Giese A: Lumbosacral glioblastoma and leptomeningeal gliomatosis complicating the course of a cervicothoracic astrocytoma WHO grade II. Childs Nerv Syst; 2007 Aug;23(8):907-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lumbosacral glioblastoma and leptomeningeal gliomatosis complicating the course of a cervicothoracic astrocytoma WHO grade II.
  • CASE REPORT: The reported female patient underwent sub-total resection of an intra-medullary cervicothoracic astrocytoma classified as WHO grade II in 1984 at the age of 18 months and received local irradiation.
  • Sixteen years later, a small recurrent cervicothoracic tumour was found and spinal seeding to the equine nerve roots and the left cerebellar cortex was apparent on MRI.
  • The patient was implanted with a ventriculoperitoneal shunt for a pseudo-tumour cerebri producing papilloedema, which eventually lead to amaurosis.
  • After an extended biopsy, the invasive lumbosacral tumour was classified as glioblastoma multiforme.
  • DISCUSSION AND CONCLUSION: Anaplastic progression and dissemination of spinal astrocytomas even two decades after initial diagnosis and treatment are rare.
  • [MeSH-major] Astrocytoma / complications. Glioblastoma / complications. Meningeal Neoplasms / complications. Spinal Cord Neoplasms / complications

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  • (PMID = 17440736.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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77. Garcés-Ambrossi GL, McGirt MJ, Mehta VA, Sciubba DM, Witham TF, Bydon A, Wolinksy JP, Jallo GI, Gokaslan ZL: Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases. J Neurosurg Spine; 2009 Nov;11(5):591-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases.
  • OBJECT: With the introduction of electrophysiological spinal cord monitoring, surgeons have been able to perform radical resection of intramedullary spinal cord tumors (IMSCTs).
  • However, factors associated with tumor resectability, tumor recurrence, and long-term neurological outcome are poorly understood.
  • Pathological type included ependymoma in 51 cases, hemangioblastoma in 15, pilocytic astrocytoma in 16, WHO Grade II astrocytoma in 10, and malignant astrocytoma in 9.
  • Independent of histological tumor type, an intraoperatively identifiable tumor plane (OR 25.3, p < 0.0001) and decreasing tumor size (OR 1.2, p = 0.05) were associated with GTR.
  • In 31 patients (31%) tumor progression developed by last follow-up (mean 19 months).
  • Tumor histology (p < 0.0001) and the presence of an intraoperatively identified tumor plane (hazard ratio [HR] 0.44, p = 0.027) correlated with improved PFS.
  • A GTR resulted in improved PFS for hemangioblastoma (HR 0.004, p = 0.04) and ependymoma (HR 0.2, p = 0.02), but not astrocytoma.
  • The presence of an identifiable tumor plane (HR 3.1, p = 0.0004) and improvement in neurological symptoms before discharge (HR 2.3, p = 0.004) were associated with overall neurological improvement by last follow-up (mean 19 months).
  • A GTR should be attempted for ependymoma and hemangioblastoma, but it may not affect PFS for astrocytoma.
  • For all tumors, the intraoperative finding of a clear tumor plane of resection carries positive prognostic significance across all pathological types.
  • [MeSH-major] Hemangioblastoma / mortality. Hemangioblastoma / surgery. Neurosurgical Procedures. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / mortality. Astrocytoma / pathology. Astrocytoma / surgery. Disease Progression. Disease-Free Survival. Ependymoma / mortality. Ependymoma / pathology. Ependymoma / surgery. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Predictive Value of Tests. Prognosis. Recovery of Function. Retrospective Studies. Risk Factors. Therapeutics. Young Adult

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  • [CommentIn] J Neurosurg Spine. 2009 Nov;11(5):588-9; discussion 590 [19929362.001]
  • (PMID = 19929363.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. McGirt MJ, Goldstein IM, Chaichana KL, Tobias ME, Kothbauer KF, Jallo GI: Extent of surgical resection of malignant astrocytomas of the spinal cord: outcome analysis of 35 patients. Neurosurgery; 2008 Jul;63(1):55-60; discussion 60-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extent of surgical resection of malignant astrocytomas of the spinal cord: outcome analysis of 35 patients.
  • OBJECTIVE: The optimal management of malignant intramedullary spinal cord astrocytomas remains controversial.
  • We report the outcomes of the surgical management of 35 malignant spinal cord astrocytomas and assess the association of extent of resection with survival after aggressive resection of these tumors.
  • METHODS: An institutional intramedullary spinal cord tumor database (1990-2002) was reviewed to identify all patients treated for malignant astrocytomas of the spinal cord (anaplastic astrocytoma [AA] or glioblastoma multiforme [GBM]).
  • Tumor involved six +/- four vertebral levels.
  • Postoperative tumor dissemination was associated with decreased survival (P = 0.004).
  • CONCLUSION: Neurological function can be preserved with aggressive resection of malignant intramedullary spinal astrocytomas; however, motor decline may be observed in many cases.
  • Biopsy alone may not provide the best outcomes for patients with malignant spinal cord tumors.
  • [MeSH-major] Astrocytoma / surgery. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery

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  • (PMID = 18728568.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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79. Chamoun RB, Alaraj AM, Al Kutoubi AO, Abboud MR, Haddad GF: Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients. Acta Neurochir (Wien); 2006 Feb;148(2):175-9; discussion 180
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  • [Title] Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients.
  • BACKGROUND: The optimal treatment of low grade intramedullary spinal cord tumours remains controversial.
  • Temozolomide is widely used for brain gliomas, yet its role in the management of spinal cord tumours has not been reported.
  • PROCEDURE: Two paediatric patients with low grade spinal cord astrocytomas were diagnosed to have progression of the tumour in spite of surgery and radiotherapy.
  • RESULTS: Stabilization of the spinal tumour in both patients was observed at 18 months of follow-up.
  • CONCLUSION: Based on our findings in two paediatric patients, temozolomide may be a useful agent in the management of progressive recurrent low grade spinal cord astrocytomas.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Astrocytoma / therapy. Dacarbazine / analogs & derivatives. Spinal Cord / pathology. Spinal Cord Neoplasms / therapy

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  • (PMID = 16374565.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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80. Sqalli Houssaini A, Ouazzani A, El Abdi B, Benchaaboune H, El Hassani M, Chakir N, Belfquih H, Arkha Y, Derraz S, El Ouahabi A, El Khamlichi A, Jiddane M: Magnetic resonance imaging for spinal cord tumors. A report of twenty cases. Neuroradiol J; 2010 Sep;23(4):484-95

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging for spinal cord tumors. A report of twenty cases.
  • This paper discusses spinal cord tumors including imaging characteristics with emphasis on magnetic resonance imaging and advances in treatment.
  • This is a retrospective study of 20 cases patients with neoplasms arising from the spinal cord.
  • Astrocytoma was noted in five cases.
  • In MRI most tumors are isointense or slightly hypointense compared to the normal cord signal with homogenous or irregular enhancement.
  • We describe the characteristic magnetic resonance findings and differential diagnosis of spinal cord tumors.
  • Spinal cord lesions comprise approximately 2-4% of all central nervous system neoplasms.
  • Magnetic resonance imaging plays a central role in the imaging of spinal cord neoplasms.

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  • (PMID = 24148644.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Sun J, Wang Z, Li Z, Liu B: Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors. J Clin Neurosci; 2009 May;16(5):666-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical treatment and functional outcomes of multi-segment intramedullary spinal cord tumors.
  • We aimed to prospectively analyze correlations between clinical features and histological classification of multi-segment intramedullary spinal cord tumors (MSICTs), and the extent of microsurgical resection and functional outcomes.
  • Fifty-six patients with MSICTs underwent microsurgery for tumor removal using a posterior approach.
  • The tumor was exposed through a dorsal myelotomy.
  • Correlation analyses were performed between functional outcome (IJOA score) and histological features, age, tumor location, and the longitudinal extent of spinal cord involvement.
  • Ependymoma was the most frequent MSICT type, seen in 22 of 56 patients (39%), followed by low grade astrocytoma (17 patients, 30%) and glioblastoma multiforme (3 patients, 5%).
  • Gross total tumor removal was achieved in 33 cases (58%), subtotal resection in 4 (7%), and partial resection in 16 (28%).
  • The histological classification of the tumor was the most important factor influencing the extent of surgical removal (chi2=22.17, p=0.00).
  • Thus, MSICTs were most commonly seen in the medullo cervical and cervicothoracic regions, with ependymoma and low grade astrocytoma the most common tumour types.
  • [MeSH-major] Laminectomy / methods. Microsurgery / methods. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neurologic Examination / methods. Outcome Assessment (Health Care). Prospective Studies. Spinal Cord / pathology. Spinal Cord / surgery. Young Adult

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  • (PMID = 19303302.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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82. Shrivastava RK, Epstein FJ, Perin NI, Post KD, Jallo GI: Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis. J Neurosurg Spine; 2005 Mar;2(3):249-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis.
  • OBJECT: Intramedullary spinal cord tumors (IMSCTs) in the older-age adult population pose complex management issues regarding the extent of resection and functional outcome, especially in terms of quality of life.
  • Ependymoma was the most common tumor (83%), and 55% were located in the thoracic spine.
  • There were two deaths due tumor progression (both malignant tumors) and one recurrence (anaplastic astrocytoma).
  • The authors recommend motor evoked potential-guided aggressive microsurgical resection, because the long-term outcome of benign lesions is excellent (good functional recovery and no tumor recurrence).
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Aged. Astrocytoma / surgery. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Quality of Life. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 15796348.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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83. Mora J, Cruz O, Gala S, Navarro R: Successful treatment of childhood intramedullary spinal cord astrocytomas with irinotecan and cisplatin. Neuro Oncol; 2007 Jan;9(1):39-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of childhood intramedullary spinal cord astrocytomas with irinotecan and cisplatin.
  • Childhood spinal cord astrocytomas are rare diseases, and their management is controversial.
  • The first patient was a 16-month-old girl who presented with a grade III intramedullary astrocytoma that rapidly progressed after surgery and adjuvant chemotherapy.
  • The second patient was a 19-month-old boy with a C3-T4 grade II intramedullary astrocytoma who received up-front vincristine and carboplatin for two months but remained clinically symptomatic.
  • A followup MRI showed a larger tumor, and the patient was switched to the I/C regimen.
  • The third patient was a 10-month-old girl with a C2-T3 grade II intramedullary astrocytoma.
  • MRI at the end of therapy showed a significant reduction in tumor size, and one year after diagnosis the patient remains symptom free.
  • Using this I/C regimen for childhood intramedullary astrocytoma, we obtained remarkable clinicoradiological responses while avoiding the use of radiotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / drug therapy. Spinal Cord Neoplasms / drug therapy

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  • (PMID = 17108066.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
  • [Other-IDs] NLM/ PMC1828108
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84. Jiménez L, Correa-Rivas M, Colón-Castillo L, Rivera-Zengotita M, Colón G, Vigo J, McBurney E: Pilomyxoid astrocytoma in unusual location in a child with neurofibromatosis type 1: case report and review of the literature. P R Health Sci J; 2010 Jun;29(2):123-6
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  • [Title] Pilomyxoid astrocytoma in unusual location in a child with neurofibromatosis type 1: case report and review of the literature.
  • Pilomyxoid astrocytoma (PMA) is a recently defined brain tumor believed to be a variant of pilocytic astrocytoma (PA), but with a more aggressive course.
  • Most PMAs occur in the optic-chiasmatic/hypothalamic (OCH) region but they have also been described in the posterior fossa, temporal lobe, and in the spinal cord.
  • Despite the fact that most of PMAs occur in the hypothalamic region, high awareness should be given to lesions in unusual locations, thus expanding the current epidemiologically known locations for this tumor.
  • [MeSH-major] Astrocytoma / diagnosis. Cerebral Ventricle Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neurofibromatosis 1

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  • (PMID = 20496528.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Puerto Rico
  • [Number-of-references] 27
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85. Huang JG, Kavar B, Smith PD: Intradural extramedullary spinal spread of oligoastrocytoma. J Clin Neurosci; 2007 Sep;14(9):879-82
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  • [Title] Intradural extramedullary spinal spread of oligoastrocytoma.
  • Spinal involvement from supratentorial oligoastrocytoma is rare, with only five previous case reports.
  • We report a patient with a past history of a frontal oligoastrocytoma who presented 26 months post-primary resection with posterior fossa disease and spinal extension, in the absence of local recurrence or malignant transformation.
  • [MeSH-major] Astrocytoma / secondary. Cranial Fossa, Posterior / pathology. Neoplasm Seeding. Spinal Cord Neoplasms / secondary

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  • (PMID = 17582770.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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86. Sandalcioglu IE, Gasser T, Asgari S, Lazorisak A, Engelhorn T, Egelhof T, Stolke D, Wiedemayer H: Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients. Spinal Cord; 2005 Jan;43(1):34-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients.
  • OBJECTIVE: To analyze factors with impact on the functional outcome for patients with surgically treated intramedullary spinal cord tumors (IMSCT) and to point out characteristics of the different histological entities.
  • Functional outcome was analyzed depending on histological features, age, tumor localization and the extension of involved spinal segments.
  • Complete tumor removal was achieved in 65 cases (83.3%) and subtotal resection in nine cases.
  • Although there was no outcome difference with respect to the age and tumor extension, thoracically located IMSCTs proved to harbor an increased risk of postoperative surgical morbidity.
  • [MeSH-major] Astrocytoma / surgery. Dermoid Cyst / surgery. Ependymoma / surgery. Hemangioblastoma / surgery. Outcome Assessment (Health Care). Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cervical Vertebrae / surgery. Child. Child, Preschool. Female. Germany. Humans. Infant. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis / pathology. Postoperative Complications / pathology. Postoperative Complications / physiopathology. Prevalence. Risk Factors. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Thoracic Vertebrae / surgery

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  • (PMID = 15326473.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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87. Raco A, Esposito V, Lenzi J, Piccirilli M, Delfini R, Cantore G: Long-term follow-up of intramedullary spinal cord tumors: a series of 202 cases. Neurosurgery; 2005 May;56(5):972-81; discussion 972-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up of intramedullary spinal cord tumors: a series of 202 cases.
  • OBJECTIVE: To review a series of patients who underwent surgical removal of intramedullary spinal cord tumors, focusing on the long-term functional outcome, recurrence rates for the various tumors, and technical problems continually debated in neurosurgical practice.
  • Lesions were located in the cervical spinal cord in 61 patients (30%), at a dorsal site in 60 (29%), at a cervicodorsal site in 51 (25%), and in the medullary cone in 30 (15%).
  • The most frequent histological tumor types were astrocytomas (86 patients, 42%) and ependymomas (68 patients, 34%).
  • CONCLUSION: Determinant predictors of a good outcome after surgery for intramedullary spinal cord tumors are histological type of lesion, complete removal of the lesion, and a satisfactory neurological status before surgery.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Astrocytoma / surgery. Brain Neoplasms / surgery. Ependymoma / surgery. Follow-Up Studies. Humans. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 15854245.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Lim BS, Park SQ, Chang UK, Kim MS: Spinal cord tanycytic ependymoma associated with neurofibromatosis type 2. J Clin Neurosci; 2010 Jul;17(7):922-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord tanycytic ependymoma associated with neurofibromatosis type 2.
  • Reports of this tumor in neurofibromatosis type 2 (NF-2) are rare.
  • MRI revealed an intramedullary lesion within the upper cervical spinal cord, which was removed surgically.
  • This rare morphology of tanycytic ependymoma could be misinterpreted as pilocytic astrocytoma or other tumor types that exhibit elongated cells.
  • [MeSH-major] Ependymoma / radiography. Neurofibromatosis 2 / radiography. Spinal Cord Neoplasms / radiography

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  • (PMID = 20403699.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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89. Sala F, Palandri G, Basso E, Lanteri P, Deletis V, Faccioli F, Bricolo A: Motor evoked potential monitoring improves outcome after surgery for intramedullary spinal cord tumors: a historical control study. Neurosurgery; 2006 Jun;58(6):1129-43; discussion 1129-43

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Motor evoked potential monitoring improves outcome after surgery for intramedullary spinal cord tumors: a historical control study.
  • OBJECTIVE: The value of intraoperative neurophysiological monitoring (INM) during intramedullary spinal cord tumor surgery remains debated.
  • The historical control group consisted of 50 patients selected from among 301 patients who underwent intramedullary spinal cord tumor surgery, previously operated on by the same team without INM.
  • Matching by preoperative neurological status (McCormick scale), histological findings, tumor location, and extent of removal were blind to outcome.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Evoked Potentials, Motor. Monitoring, Intraoperative. Spinal Cord Neoplasms / surgery

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  • (PMID = 16723892.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Distelmaier F, Janssen G, Mayatepek E, Schaper J, Göbel U, Rosenbaum T: Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay. J Neurooncol; 2006 Sep;79(2):197-201
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  • [Title] Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay.
  • In this report we present an unusual case of severe emaciation in a 4(9)/(12)-year-old girl with a juvenile pilocytic astrocytoma of the hypothalamic region and brain stem with neuroaxis dissemination.
  • This case illustrates the importance of considering intracranial mass-lesions in the differential diagnosis of weight loss, psychological disturbance and atypical eating disorder.
  • We discuss the importance of tumor multifocality and the role of patient age in the clinical presentation with reference to the literature.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Emaciation / etiology. Feeding and Eating Disorders / etiology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Stem / pathology. Child, Preschool. Diagnosis, Differential. Feeding and Eating Disorders of Childhood / diagnosis. Female. Humans. Hypothalamus / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / secondary. Treatment Outcome


91. Simal-Julián JA, Sanchis-Martín R, Prat-Acín R, Miranda-Lloret P, Conde-Sardón R, Cárdenas-Ruiz-Valdepeñas E, Beltrán-Giner A: [Spinal pleomorphic xantoastrocytoma. Case report]. Neurocirugia (Astur); 2010 Oct;21(5):390-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal pleomorphic xantoastrocytoma. Case report].
  • [Transliterated title] Xantoastrocitoma pleomórfico espinal. Caso clínico.
  • INTRODUCTION: we report the clinical, radiological and pathological features of a spinal pleomorphic xanthoastrocytoma, an unusual neoplastic entity in a really rare location, establish an appropriated management of these lesions and review the short available english literature.
  • The differential imagine diagnosis was established between intramedullary astrocytoma and ependimoma.
  • DISCUSSION AND CONCLUSION: comparing to published cases about intracranial pleomorphic xanthoastrocytomas, spinal pleomorphic xanthoastrocytomas (SPXA) present different epidemiological characteristics.
  • The hypothesis about a more aggressive behaviour of PXA in spinal cord may be corroborated after literature review.
  • Removal extension is crucial in the prevention of tumour recurrence.
  • Adyuvant radiotherapy should only be considered when there is postoperative residual tumour and/or anaplastic features.
  • [MeSH-major] Astrocytoma. Spinal Cord Neoplasms

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  • (PMID = 21042690.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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92. Abel TJ, Chowdhary A, Jallo G, Wang PP, Burger P, Avellino AM: Thoracic spinal cord compression by intramedullary hamartomatous tissue in a young boy: case report. Neurosurgery; 2008 Jun;62(6):E1380-1; discussion E1381
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thoracic spinal cord compression by intramedullary hamartomatous tissue in a young boy: case report.
  • OBJECTIVE: Spinal cord hamartomas are a rare occurrence characterized by well- differentiated mature elements located in an irregular position in the spinal cord.
  • CLINICAL PRESENTATION: The authors present the unique case of a 12-year-old boy who originally presented to our center for treatment of a right thalamic astrocytoma.
  • Spinal magnetic resonance imaging performed at this time revealed an intramedullary spinal cord lesion from T4 to T8, which was later found to be composed of hamartomatous tissue.
  • CONCLUSION: Although typically described in the literature as spinal cord hamartomas because of their histological composition, these rare hamartomatous lesions may be the result of a neurulation defect rather than true hamartomas.
  • [MeSH-major] Hamartoma / pathology. Spinal Cord Compression / etiology

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  • (PMID = 18824961.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. O'Shaughnessy J, Bussières A: Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. J Can Chiropr Assoc; 2006 Dec;50(4):244-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report.
  • Cervical, thoracic and lumbar spinal radiographs were deemed unremarkable.
  • A magnetic resonance imaging (MRI) study was performed and revealed an expansive intramedullary lesion between C6 and T1 suggesting a differential diagnosis of spinal cord ependymoma or astrocytoma.
  • The patient underwent surgical excision of the tumour.
  • In the presence of subtle clinical signs, clinicians should keep a high index of suspicion for spinal cord tumours.

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  • [Cites] Spinal Cord. 1999 Nov;37(11):753-9 [10578245.001]
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  • (PMID = 17549184.001).
  • [ISSN] 0008-3194
  • [Journal-full-title] The Journal of the Canadian Chiropractic Association
  • [ISO-abbreviation] J Can Chiropr Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC1840009
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94. Eroes CA, Zausinger S, Kreth FW, Goldbrunner R, Tonn JC: Intramedullary low grade astrocytoma and ependymoma. Surgical results and predicting factors for clinical outcome. Acta Neurochir (Wien); 2010 Apr;152(4):611-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary low grade astrocytoma and ependymoma. Surgical results and predicting factors for clinical outcome.
  • INTRODUCTION: The optimal time point for surgery of intramedullary spinal astrocytomas and ependymomas is often debated on, as predicting factors are poorly defined.
  • Complete tumor resection was achieved in 79% of ependymomas, 50% of astrocytomas WHO grade I, and 14% of astrocytomas WHO grade II (significantly more often in ependymomas than in astrocytomas, p < 0.05).
  • Preoperative MCS <3 and extent of tumor <5 levels were significantly (p = 0.01 and p < 0.05) associated with a favorable outcome (MCS <3) in early and late follow-up.
  • CONCLUSION: An MCS of less than 3 and a tumor extent of less than 5 levels are the most important factors for a favorable postoperative functional outcome.
  • Therefore, surgery should be initiated before significant clinical symptomatology or substantial tumor growth occurs.
  • [MeSH-major] Astrocytoma / surgery. Ependymoma / surgery. Spinal Cord Neoplasms / surgery

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  • (PMID = 20119838.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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95. Kim NR, Chung DH, Lee SK, Ha SY: Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings. J Korean Med Sci; 2007 Sep;22 Suppl:S149-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings.
  • Clear cell ependymoma was included in the World Health Organization classification of the nervous system in 1993, and all the reported cases, except for two in the spinal cord, were located in the brain, mainly in the supratentorial compartment.
  • Astrocytomas outnumber ependymomas in the spinal cord, and the two entities partly share cytologic findings such as long, bipolar glial processes and oval to round nuclei resembling those seen in pilocytic astrocytoma.
  • Here, we report the first Korean case of intramedullary clear cell ependymoma of the spinal cord, which is the third case situated in the spinal cord in the literature.
  • On hematoxylin-eosin stain, oval to round tumor cells had large central nuclei with indistinct nucleoli and a moderate amount of clear cytoplasm, i.e. perinuclear halo, mimicking oligodendroglioma.
  • [MeSH-major] Ependymoma / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 17923743.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2694393
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96. Munshi A, Talapatra K, Ramadwar M, Jalali R: Spinal epidermoid cyst with sudden onset of paraplegia. J Cancer Res Ther; 2009 Oct-Dec;5(4):290-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal epidermoid cyst with sudden onset of paraplegia.
  • Spinal epidermoid cysts, whether congenital or iatrogenic, are relatively uncommon in the spinal cord.
  • We describe an unusual presentation in a 3-year-old male child which mimicked astrocytoma clinicoradiologically.
  • [MeSH-major] Epidermal Cyst / complications. Epidermal Cyst / pathology. Paraplegia / etiology. Spinal Diseases / complications. Spinal Diseases / pathology

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  • (PMID = 20160364.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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97. Loh JK, Lin CK, Hwang YF, Hwang SL, Kwan AL, Howng SL: Primary spinal tumors in children. J Clin Neurosci; 2005 Apr;12(3):246-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal tumors in children.
  • Nine patients, 16 years of age or younger with primary spinal cord tumors, diagnosed between 1991 and 2003 at The Kaohsiung University Hospital, were reviewed retrospectively.
  • Two tumors were located primarily in the cervical cord (1 meningioma, 1 neurofibroma), five were predominantly thoracic (1 lymphoma, 1 meningioma, 1 astrocytoma, 1 fibrosarcoma and 1 osteoblastoma), one lumbar (ependymoma), and one sacral (Ewing's sarcoma).
  • Radical surgery should be considered in benign primary spinal cord tumors.
  • [MeSH-major] Spinal Neoplasms / pathology. Spinal Neoplasms / therapy

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  • (PMID = 15851074.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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98. MacDonald TJ, Arenson EB, Ater J, Sposto R, Bevan HE, Bruner J, Deutsch M, Kurczynski E, Luerssen T, McGuire-Cullen P, O'Brien R, Shah N, Steinbok P, Strain J, Thomson J, Holmes E, Vezina G, Yates A, Phillips P, Packer R: Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933. Cancer; 2005 Dec 15;104(12):2862-71
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  • [Title] Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933.
  • The authors conclude that these commonly used HDCT regimens provide no additional clinical benefit to conventional treatment in HGA, regardless of the amount of measurable residual tumor.
  • [MeSH-minor] Adolescent. Adult. Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / mortality. Brain Stem Neoplasms / pathology. Brain Stem Neoplasms / radiotherapy. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Humans. Male. Neoplasm Staging. Probability. Prognosis. Prospective Studies. Radiotherapy, High-Energy. Reference Values. Risk Assessment. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiotherapy. Survival Analysis. Time Factors. Treatment Outcome

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  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 16315242.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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99. Hicdonmez T, Kilincer C, Hamamcioglu MK, Cobanoglu S: Paraplegia due to spinal subdural hematoma as a complication of posterior fossa surgery: Case report and review of the literature. Clin Neurol Neurosurg; 2006 Sep;108(6):590-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraplegia due to spinal subdural hematoma as a complication of posterior fossa surgery: Case report and review of the literature.
  • Although blood contamination of cerebrospinal fluid (CSF) after an intracranial operation is possible, development of a symptomatic spinal hematoma after a posterior fossa surgery has never been reported.
  • A 43-year-old woman underwent a posterior fossa tumor removal in the prone position with no intraoperative difficulty.
  • On the second postoperative day, she complained of severe epigastric pain and developed a rapid onset of paraplegia with anesthesia below the thoracic 5 spinal level.
  • The emergency cranial and spinal MRIs revealed a spinal extramedullary hemorrhage spreading to the whole spinal regions, just sparing the cauda equina area.
  • There was a prominent localized hematoma formation surrounding and compressing the spinal cord at the upper thoracic levels, which was evacuated via an urgent laminectomy.
  • Development of the spinal hematoma was explained by the movement of blood from the tumor bed into the spinal canal under the effect of gravity, during or after the operation.
  • We conclusively suggest that a spinal hematoma should be taken into consideration as a rare but potentially severe complication of a posterior fossa surgery.
  • Meticulous hemostasis and isolation of the surgical area from the spinal spaces are essential.
  • Postoperatively, patients should be monitored for spinal findings as well as cranial signs.
  • [MeSH-major] Astrocytoma / surgery. Hematoma, Subdural, Spinal / etiology. Infratentorial Neoplasms / surgery. Paraplegia / etiology. Postoperative Complications

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  • (PMID = 15890442.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 15
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100. Papavero L, Hagel C, Grzyska U, Fritsche E, Westphal M: August 2004: 64-year-old man with intermittent paresthesia of the abdomen and of the legs. Brain Pathol; 2005 Jan;15(1):91-2, 95

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Additional slowly rising symptoms, such as tingling of the legs, mild gait ataxia and painful micturition, led to MRI investigation of the spinal cord.
  • A fusiform enlargement of the cord extending from T5 to T8 was shown.
  • The space occupying lesion infiltrated diffusely the spinal cord.
  • A contrast medium enhancing exophytic tumor pellet was approached via a 2-level laminoplasty and resected.
  • Biopsies were taken from different exophytic tumor areas whereas the intramedullary part was spared.
  • The histologic examination confirmed the typical pattern of a pilocytic astrocytoma in all specimens.
  • In our surgical experience with 226 intramedullary tumors and with 117 patients affected by intracranial pilocytic astrocytoma this case is unique because of its combination of tumor location, growth pattern and age of the patient.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / physiopathology. Paresthesia / etiology. Spinal Cord Neoplasms / physiopathology

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  • (PMID = 15779244.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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