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1. Yan B, Chour HH, Peh BK, Lim C, Salto-Tellez M: RhoA protein expression correlates positively with degree of malignancy in astrocytomas. Neurosci Lett; 2006 Oct 23;407(2):124-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] RhoA protein expression correlates positively with degree of malignancy in astrocytomas.
  • Astrocytic tumors are the most common intracranial neoplasms.
  • Based on direct analysis of clinical materials, our study demonstrates increased expression of RhoA in high-grade astrocytomas.
  • This observation may be relevant to astrocytoma biology and the development of potential therapeutics against high-grade astrocytomas.
  • Of more immediate consequence, utilization of this marker may aid in the routine pathological grading (and hence prognostication) of astrocytomas.
  • [MeSH-major] Astrocytoma / metabolism. Astrocytoma / pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. rhoA GTP-Binding Protein / biosynthesis

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  • (PMID = 16978776.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 3.6.5.2 / rhoA GTP-Binding Protein
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2. Kida Y, Yoshimoto M, Hasegawa T: Radiosurgery for intracranial gliomas. Prog Neurol Surg; 2009;22:122-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for intracranial gliomas.
  • Long-term results of radiosurgery for GI to GIV astrocytomas are described.
  • We have treated 172 astrocytoma cases in total, including 25 GI cases, 52 GII cases, 41 GIII cases and 54 GIV astrocytoma cases.
  • The maximum and marginal doses for GI astrocytomas were significantly lower than those for the other three grades due to their proximity to the optic nerves.
  • However, the response rates of GIII and GIV astrocytomas were very low.
  • [MeSH-major] Astrocytoma / mortality. Astrocytoma / surgery. Brain Neoplasms / mortality. Brain Neoplasms / surgery. Radiosurgery

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  • (PMID = 18948724.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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3. Jeong SM, Chung YG, Lee JB, Shin IY: Intracranial dissemination from spinal cord anaplastic astrocytoma. J Korean Neurosurg Soc; 2010 Jan;47(1):68-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial dissemination from spinal cord anaplastic astrocytoma.
  • We report a case of intracranial dissemination developing approximately 4 months after partial removal of a spinal cord anplastic astrocytoma in a 22-year-old male.
  • The final histologic diagnosis was anaplastic astrocytoma.
  • He underwent computed tomography-guided stereotactic biopsy and histological appearance was consistent with anaplastic astrocytoma.
  • The clinical course indicates that the tumor originated in the spinal cord and extended into the subarachnoid space, first the spinal canal and later intracranial.

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  • (PMID = 20157383.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2817520
  • [Keywords] NOTNLM ; Anaplastic astrocytoma / Intracranial dissemination / Spinal cord
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4. Gelabert-González M: [Delayed brain haematoma following stereotactic biopsy]. Neurocirugia (Astur); 2007 Feb;18(1):36-9
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  • The use of stereotactic biopsy sampling in the management of intracranial lesions has been well established; due to its minimally invasive nature, the potential risks associated to this procedure are sometimes understimated.
  • [MeSH-minor] Adult. Astrocytoma / diagnosis. Astrocytoma / pathology. Brain Neoplasms / diagnosis. Brain Neoplasms / pathology. Frontal Lobe / injuries. Headache / etiology. Humans. Male. Stereotaxic Techniques. Time Factors

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  • (PMID = 17393044.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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5. Jang SY, Kong MH, Song KY, Frazee JG: Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult. J Korean Neurosurg Soc; 2009 Jun;45(6):381-5
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  • [Title] Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult.
  • The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report.
  • Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord.
  • The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II).
  • When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

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  • (PMID = 19609424.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2711238
  • [Keywords] NOTNLM ; Astrocytoma / Cranial metastases / Intramedullary / Spinal cord tumor
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6. Distelmaier F, Janssen G, Mayatepek E, Schaper J, Göbel U, Rosenbaum T: Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay. J Neurooncol; 2006 Sep;79(2):197-201
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay.
  • In this report we present an unusual case of severe emaciation in a 4(9)/(12)-year-old girl with a juvenile pilocytic astrocytoma of the hypothalamic region and brain stem with neuroaxis dissemination.
  • This case illustrates the importance of considering intracranial mass-lesions in the differential diagnosis of weight loss, psychological disturbance and atypical eating disorder.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Emaciation / etiology. Feeding and Eating Disorders / etiology


7. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK: Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev; 2007 Nov 1;21(21):2683-710
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors.
  • [MeSH-major] Astrocytoma / genetics. Astrocytoma / pathology. Astrocytoma / therapy. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Brain Neoplasms / therapy

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  • (PMID = 17974913.001).
  • [ISSN] 0890-9369
  • [Journal-full-title] Genes & development
  • [ISO-abbreviation] Genes Dev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA099041; United States / NCI NIH HHS / CA / CA95616
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 306
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8. Blauwblomme T, Varlet P, Goodden JR, Cuny ML, Piana H, Roujeau T, Dirocco F, Grill J, Kieffer V, Boddaert N, Sainte-Rose C, Puget S: Forniceal glioma in children. Clinical article. J Neurosurg Pediatr; 2009 Sep;4(3):249-53
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  • Presenting features included intracranial hypertension (7 cases), hypothalamic dysfunction (2), and memory dysfunction (3).
  • On histological review, the tumors were confirmed as pilocytic astrocytoma (4 lesions), WHO Grade II astrocytoma (3), and ganglioglioma (1).

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  • (PMID = 19772409.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Berhouma M: Management of subependymal giant cell tumors in tuberous sclerosis complex: the neurosurgeon's perspective. World J Pediatr; 2010 May;6(2):103-10
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  • The data were collected after a bibliography made using PubMed/Medline with these terms: subependymal, subependymal giant cell astrocytoma, subependymal giant cell tumor, and tuberous sclerosis complex.
  • CONCLUSIONS: An earlier diagnosis of SGCT in neurologically asymptomatic children with TSC may allow a precocious surgical removal of the tumor before the installation of increased intracranial pressure signs, an attitude that is being progressively adopted to lessen the morbimortality rate.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Tuberous Sclerosis / complications
  • [MeSH-minor] Algorithms. Child. Humans. Hydrocephalus / etiology. Intracranial Hypertension / etiology. Mutation. Neurosurgical Procedures. Tumor Suppressor Proteins / genetics

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  • (PMID = 20490765.001).
  • [ISSN] 1867-0687
  • [Journal-full-title] World journal of pediatrics : WJP
  • [ISO-abbreviation] World J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; 4JG2LF96VF / tuberous sclerosis complex 2 protein
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10. Mehrazin M, Rahmat H, Yavari P: Epidemiology of primary intracranial tumors in Iran, 1978-2003. Asian Pac J Cancer Prev; 2006 Apr-Jun;7(2):283-8
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  • [Title] Epidemiology of primary intracranial tumors in Iran, 1978-2003.
  • The five most common histological types in both sexes were meningioma in 892 cases (26%) followed by astrocytoma in 805 cases (23.4%), pituitary adenoma in 488 cases (14.2%), glioblasomaoma in 278 cases (5.1%) and ependymoma in 166 cases (4.8%).
  • Male predominance was observed for the astrocytoma group, craniopharyngiomas, ependymomas, glioblastomas, medulloblastomas, and pituitary adenomas.

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  • (PMID = 16839224.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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11. Muzumdar D, Ventureyra EC: Tonsillar herniation and cervical syringomyelia in association with posterior fossa tumors in children: a case-based update. Childs Nerv Syst; 2006 May;22(5):454-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They frequently present with raised intracranial pressure and may have tonsillar herniation.
  • CASE REPORT: We describe a case of a pilocytic astrocytoma of the cerebellum in a 13-year-old girl who presented with clinical features of progressively worsening raised intracranial pressure and secondary tonsillar herniation and cervical syringomyelia.
  • CONCLUSIONS: The occurrence of tonsillar herniation and syringomyelia in association with a slow growing benign tumor like pilocytic astrocytoma of the cerebellum is uncommon.
  • [MeSH-major] Astrocytoma. Hernia / etiology. Infratentorial Neoplasms / complications. Palatine Tonsil / pathology. Syringomyelia / etiology

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  • (PMID = 16397818.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Ramírez-Zamora A, Biller J: Brainstem cavernous malformations: a review with two case reports. Arq Neuropsiquiatr; 2009 Sep;67(3B):917-21
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  • We present one case of 'de novo' brainstem cavernous malformation after radiation therapy adding to the increasing number of reported cases in the medical literature, and the case of a pregnant patient with symptomatic intracranial hemorrhage related to brainstem CMs to illustrate the complex nature in management of these patients, followed by a review of clinical and radiographic characteristics.
  • CMs account for 8-15% of all intracranial and intraspinal vascular malformations.
  • Although traditionally thought to be congenital in origin, CMs may present as acquired lesions particularly after intracranial radiation therapy.
  • [MeSH-major] Brain Stem. Cerebral Hemorrhage / etiology. Intracranial Arteriovenous Malformations / diagnosis. Pregnancy Complications, Cardiovascular / diagnosis
  • [MeSH-minor] Adult. Astrocytoma / radiotherapy. Cerebellar Neoplasms / radiotherapy. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Pregnancy. Radiotherapy / adverse effects

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  • (PMID = 19838533.001).
  • [ISSN] 1678-4227
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 40
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13. Gelabert-González M, Seramito-García R, Bandín-Diéguez J, Allut AG: [Bilateral thalamic tumours. Three case reports and a review of the literature]. Rev Neurol; 2007 Nov 16-30;45(10):599-603
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  • INTRODUCTION: Thalamic tumours account for approximately 1% to 5% of all brain tumours, and are usually unilateral astrocytoma and frequently affect children.
  • Symptoms of mental impairment were present in 13 cases (50%) and sings of intracranial hypertension in 7 (26.9%).

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  • (PMID = 18008265.001).
  • [ISSN] 0210-0010
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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14. López-Aguilar E, Sepúlveda-Vildósola AC, Betanzos-Cabrera Y, Rocha-Moreno YG, Gascón-Lastiri G, Rivera-Márquez H, Wanzke-del-Angel V, Cerecedo-Díaz F, de la Cruz-Yañez H: Phase II study of metronomic chemotherapy with thalidomide, carboplatin-vincristine-fluvastatin in the treatment of brain stem tumors in children. Arch Med Res; 2008 Oct;39(7):655-62
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  • BACKGROUND: Brain stem tumors (BST) constitute 20% of all intracranial tumors.
  • Five patients had low-grade astrocytomas, three patients had glioblastoma multiforme, and one patient presented high-grade astrocytoma.

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  • (PMID = 18760193.001).
  • [ISSN] 0188-4409
  • [Journal-full-title] Archives of medical research
  • [ISO-abbreviation] Arch. Med. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Fatty Acids, Monounsaturated; 0 / Indoles; 4L066368AS / fluvastatin; 4Z8R6ORS6L / Thalidomide; 5J49Q6B70F / Vincristine; BG3F62OND5 / Carboplatin
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15. Ramina R, Coelho Neto M, Fernandes YB, Borges G, Honorato DC, Arruda WO: Intrinsic tectal low grade astrocytomas: is surgical removal an alternative treatment? Long-term outcome of eight cases. Arq Neuropsiquiatr; 2005 Mar;63(1):40-5
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  • [Title] Intrinsic tectal low grade astrocytomas: is surgical removal an alternative treatment? Long-term outcome of eight cases.
  • Some authors propose only clinical observation until the patient present signs of increased intracranial pressure when a shunt with or without biopsy, is inserted; others recommend radiotherapy after stereotactic or open biopsy.
  • We present a retrospective analysis of eight patients (mean age 16.6 +/- 11.5 years-old) with low-grade astrocytoma of the tectal region operated on using an infratentorial/supracerebellar approach between 1981 and 2002.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery

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  • (PMID = 15830063.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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16. Maes L, Kalala JP, Cornelissen M, de Ridder L: Progression of astrocytomas and meningiomas: an evaluation in vitro. Cell Prolif; 2007 Feb;40(1):14-23
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  • [Title] Progression of astrocytomas and meningiomas: an evaluation in vitro.
  • By verifying the proliferation capacity, human telomerase reverse transcriptase (hTERT) expression and in vitro invasion, in a group of highly malignant glioblastomas, benign meningiomas and astrocytomas, at the initial stage of progression, we have analysed putative progression in vitro for proliferation and telomerase expression.
  • MATERIALS AND METHODS: The relative proliferation status (visualized with Ki-67 antibodies) and presence of hTERT protein was analysed in 27 intracranial tumours (6 astrocytomas, 8 glioblastomas and 13 meningiomas) by immunohistochemistry on paraffin-embedded biopsy tissue, as well as on primary tumour-derived cell cultures.
  • RESULTS: The mean proliferation indices were 22.3 (SD = 18.1) for glioblastomas and 2.1 (SD = 1.9) for low-grade (LG) astrocytomas.
  • Mean percentages of staining for hTERT varied between 36.5 (SD = 28.4) for glioblastomas and 10.2 (SD = 8.6) for LG astrocytomas.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cell Proliferation. Ki-67 Antigen / biosynthesis. Meningeal Neoplasms / pathology. Meningioma / pathology

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  • (PMID = 17227292.001).
  • [ISSN] 0960-7722
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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17. Mayes DA, Hu Y, Teng Y, Siegel E, Wu X, Panda K, Tan F, Yung WK, Zhou YH: PAX6 suppresses the invasiveness of glioblastoma cells and the expression of the matrix metalloproteinase-2 gene. Cancer Res; 2006 Oct 15;66(20):9809-17
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  • Using real-time quantitative reverse transcription-PCR (RT-PCR), gelatin zymography, and immunohistochemistry assays, the expression of the gene encoding matrix metalloproteinase-2 (MMP2) in GBM cell lines grown in vitro or in intracranial xenografts in nude mice was shown to be repressed by either stable or adenoviral-mediated overexpression of PAX6.
  • A significant reverse correlation (P < 0.05) occurred between PAX6 and MMP2 expression quantified by real-time quantitative RT-PCR in 41 GBMs, 43 anaplastic astrocytomas, and 7 adjacent normal tissues.
  • Interestingly, the degree and significance of the reverse correlation increased after excluding astrocytomas, whereas it became insignificant after excluding GBMs.
  • [MeSH-minor] Adenoviridae / genetics. Animals. Astrocytoma / enzymology. Astrocytoma / genetics. Astrocytoma / pathology. Cell Line, Tumor. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Mice. Mice, Nude. Neoplasm Invasiveness. Promoter Regions, Genetic. Transfection. Transplantation, Heterologous

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  • (PMID = 17047041.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / RR020146
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / Homeodomain Proteins; 0 / PAX6 protein; 0 / Paired Box Transcription Factors; 0 / Repressor Proteins; EC 3.4.24.24 / Matrix Metalloproteinase 2
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18. Porter A, Lyons MK, Wingerchuk DM, Bosch EP: Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. Clin Neurol Neurosurg; 2006 Dec;108(8):787-9
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  • [Title] Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension.
  • Increased intracranial pressure is rarely seen in association with spinal tumors.
  • We describe a young, non-obese man who presented with increased intracranial pressure, papilledema and visual obscuration.
  • Multiple cerebrospinal fluid (CSF) examinations with normal or minimally elevated CSF protein lead to the initial diagnosis of idiopathic intracranial hypertension.
  • Open biopsy confirmed a grade 3 fibrillary astrocytoma.
  • The suspected mechanisms of spinal tumors causing increased intracranial pressure are reviewed as well as three other cases of spinal astrocytomas previously reported in the literature that presented with papilledema and increased intracranial pressure without hydrocephalus.
  • This case illustrates that increased intracranial pressure may in exceptional cases of spinal tumors precede the more typical myelopathic presentation by months and mimic idiopathic intracranial hypertension.
  • [MeSH-major] Astrocytoma / diagnosis. Pseudotumor Cerebri / etiology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 16298472.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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19. Papavero L, Hagel C, Grzyska U, Fritsche E, Westphal M: August 2004: 64-year-old man with intermittent paresthesia of the abdomen and of the legs. Brain Pathol; 2005 Jan;15(1):91-2, 95
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  • The histologic examination confirmed the typical pattern of a pilocytic astrocytoma in all specimens.
  • In our surgical experience with 226 intramedullary tumors and with 117 patients affected by intracranial pilocytic astrocytoma this case is unique because of its combination of tumor location, growth pattern and age of the patient.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / physiopathology. Paresthesia / etiology. Spinal Cord Neoplasms / physiopathology

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  • (PMID = 15779244.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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20. Jang FF, Wei W, De WM: Vascular endothelial growth factor and basic fibroblast growth factor expression positively correlates with angiogenesis and peritumoural brain oedema in astrocytoma. J Ayub Med Coll Abbottabad; 2008 Apr-Jun;20(2):105-9
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  • [Title] Vascular endothelial growth factor and basic fibroblast growth factor expression positively correlates with angiogenesis and peritumoural brain oedema in astrocytoma.
  • BACKGROUND: Astrocytoma is the most malignant intracranial neoplasm and is characterized by high neovascularization and peritumoural brain oedema.
  • METHODS: The expression of two angiogenic growth factors, vascular endothelial growth factor and basic fibroblast growth factor were investigated using immunohistochemistry for astrocytoma from 82 patients and 11 normal human tissues.
  • RESULTS: The expression of vascular endothelial growth factor and basic fibroblast growth factor positively correlate with the pathological grade of astrocytoma, microvessel density numbers and brain oedema, which may be responsible for the increased tumour neovascularization and peritumoural brain oedema.
  • CONCLUSION: The results support the idea that inhibiting vascular endothelial growth factor and basic fibroblast growth factor are useful for the treatment of human astrocytoma and to improve patient's clinical outcomes and prognosis.
  • [MeSH-major] Astrocytoma / blood supply. Brain Edema / etiology. Brain Neoplasms / blood supply. Fibroblast Growth Factor 2 / biosynthesis. Neovascularization, Pathologic / metabolism. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 19385471.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2
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21. Greco Crasto S, Soffietti R, Rudà R, Cassoni P, Ducati A, Davini O, De Lucchi R, Rizzo L: Diffusion-Weighted Magnetic Resonance Imaging and ADC Maps in the Diagnosis of Intracranial Cystic or Necrotic Lesions. A Retrospective Study on 49 Patients. Neuroradiol J; 2007 Dec 31;20(6):666-75
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  • [Title] Diffusion-Weighted Magnetic Resonance Imaging and ADC Maps in the Diagnosis of Intracranial Cystic or Necrotic Lesions. A Retrospective Study on 49 Patients.
  • Eleven tumours (11/44) appeared hyperintense on DWI: eight metastases from lung cancer (mean ADC value 0.86 mm(2)/s, range 0.75-1.2 mm(2)/s), two GBMs (mean 0.7 mm(2)/s, range 0.67-0.76 mm(2)/s) and one anaplastic astrocytoma (ADC value 1.24 mm(2)/s).

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  • (PMID = 24300002.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Seddighi AS, Seddighi A: Extramedullary hematopoiesis presenting as a compressive cord and cerebral lesion in a patient without a significant hematologic disorder: a case report. J Med Case Rep; 2010;4:319
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  • INTRODUCTION: Intracranial or spinal compressive lesions due to extramedullary hematopoiesis have been reported in the medical literature.
  • Most of the reported cases are extradural lesions or, on rare occasions, foci within another neoplasm such as hemangioblastoma, meningioma or pilocytic astrocytoma.
  • CASE PRESENTATION: We report the case of a 43-year-old Iranian woman in whom extramedullary hematopoiesis presented as a compressive cord lesion and then later as an intracranial lesion.

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  • (PMID = 20939863.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2972301
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23. Grossman SA, Alavi JB, Supko JG, Carson KA, Priet R, Dorr FA, Grundy JS, Holmlund JT: Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas. Neuro Oncol; 2005 Jan;7(1):32-40
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  • [Title] Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas.
  • Their median age was 46 years (range, 28-68 years), median Karnofsky performance status was 80 (range, 60-100), median tumor volume was 58 cm3 (range, 16-254 cm3), and histology included glioblastoma multiforme (n = 16), anaplastic oligodendroglioma (n = 4), and anaplastic astrocytoma (n = 1).
  • Patients on this therapy rapidly developed symptoms of increased intracranial pressure with increased edema, enhancement, and mass effect on neuroimaging.

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  • (PMID = 15701280.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA062475; United States / NCI NIH HHS / CA / U01-CA-26406; United States / NCI NIH HHS / CA / UO1CA-62475
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oligonucleotides, Antisense; 0 / Phosphorothioate Oligonucleotides; EC 2.7.11.13 / PRKCA protein, human; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / Protein Kinase C-alpha; FMT95051CQ / aprinocarsen
  • [Other-IDs] NLM/ PMC1871621
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24. Sasayama T, Nishihara M, Tanaka K, Mizukawa K, Ehara K, Kanomata N, Kohmura E: Two metachronous tumors induced by radiation therapy: case report and review of the literature. J Neurooncol; 2008 Jul;88(3):315-20
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  • Various radiation-induced tumors, including meningioma, glioma, and sarcoma, have been reported; however, metachronous intracranial double tumors induced by radiation therapy are extremely rare.
  • The patient underwent stereotactic biopsy, and the tumor was found to be an anaplastic astrocytoma.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasms, Radiation-Induced / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 18373066.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Groves MD, Katz RL: Low grade astrocytoma presenting with visual loss. J Neurooncol; 2008 Aug;89(1):49-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low grade astrocytoma presenting with visual loss.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Optic Nerve Neoplasms / secondary. Spinal Cord Neoplasms / secondary. Thalamus / pathology. Vision, Low / etiology
  • [MeSH-minor] Adolescent. Antineoplastic Agents, Alkylating / pharmacology. Antineoplastic Agents, Alkylating / therapeutic use. Biomarkers, Tumor. Dacarbazine / analogs & derivatives. Dacarbazine / pharmacology. Dacarbazine / therapeutic use. Humans. Intracranial Hypertension / etiology. Intracranial Hypertension / physiopathology. Magnetic Resonance Imaging. Male. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Optic Nerve / pathology. Optic Nerve / physiopathology. PTEN Phosphohydrolase / genetics. Papilledema / etiology. Papilledema / physiopathology. Phosphatidylinositol 3-Kinases / genetics. Receptor, Epidermal Growth Factor / genetics. Subarachnoid Space / pathology. Subarachnoid Space / physiopathology

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  • (PMID = 18398571.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Biomarkers, Tumor; 7GR28W0FJI / Dacarbazine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.1.3.67 / PTEN protein, human; YF1K15M17Y / temozolomide
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26. Prothmann S, Puccini S, Dalitz B, Kühn A, Rödel L, Zimmer C, Kahn T: [Preoperative mapping of speech-eloquent areas with functional magnetic resonance imaging (fMRI): comparison of different task designs]. Rofo; 2005 Nov;177(11):1522-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Astrocytoma / physiopathology. Astrocytoma / surgery. Female. Functional Laterality. Glioblastoma / physiopathology. Glioblastoma / surgery. Glioma / physiopathology. Glioma / surgery. Humans. Intracranial Arteriovenous Malformations / physiopathology. Intracranial Arteriovenous Malformations / surgery. Linear Models. Male. Meningeal Neoplasms / physiopathology. Meningeal Neoplasms / surgery. Meningioma / physiopathology. Meningioma / surgery. Middle Aged

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  • (PMID = 16302133.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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27. Kaptigau WM, Ke L: Space-occupying lesions in Papua New Guinea--the CT era. P N G Med J; 2007 Mar-Jun;50(1-2):33-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: There were 42 SOL cases affecting the intracranial space and the spine.
  • There were 6 astrocytomas and 3 meningiomas followed by secondaries, pilocytic astrocytoma and medulloblastoma with 2 cases each.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Astrocytoma / radiography. Child. Child, Preschool. Female. Humans. Infant. Male. Meningioma / radiography. Middle Aged. Papua New Guinea. Sex Distribution. Tomography, X-Ray Computed. Young Adult


28. White JB, Piepgras DG, Scheithauer BW, Parisi JE: Rate of spontaneous hemorrhage in histologically proven cases of pilocytic astrocytoma. J Neurosurg; 2008 Feb;108(2):223-6
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  • [Title] Rate of spontaneous hemorrhage in histologically proven cases of pilocytic astrocytoma.
  • The rate of tumor-related intracranial hemorrhage is variably reported from <1 to 14.6%.
  • Hemorrhage in primary gliomas occurs in 3.7-7.2% of gliomas, mainly in glioblastoma muliforme and oligodendroglioma with low-grade astrocytomas accounting for <1%.
  • Hemorrhage associated with pilocytic astrocytomas (PAs) is only sporadically reported.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Cerebral Hemorrhage / etiology


29. Zadeh G, Reti R, Koushan K, Baoping Q, Shannon P, Guha A: Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1. Neoplasia; 2005 Dec;7(12):1081-90
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  • [Title] Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1.
  • Malignant astrocytomas are the most common and highly vascularized of all primary adult brain tumors.
  • The histopathological hallmarks of malignant astrocytomas are microvascular proliferation and formation of vascular entities, which are referred to as "glomeruloid bodies."
  • The significance of glomeruloid bodies and the molecular mechanisms driving the abnormal vascular architecture in malignant astrocytomas are not understood.
  • We have observed that overexpression of angiopoietin-1 (Ang1) in both subcutaneous and intracranial xenograft models of malignant astrocytomas reproduces many of the vascular features of these tumors, including glomeruloid bodies.
  • Collectively, these results support our hypothesis that Ang1 is a key molecular regulator of pathological vascularization characteristic of malignant astrocytomas.
  • [MeSH-major] Angiopoietin-1 / metabolism. Astrocytoma / metabolism. Brain Neoplasms / metabolism. Neovascularization, Pathologic / metabolism

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  • (PMID = 16354591.001).
  • [ISSN] 1522-8002
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Angiopoietin-1; 0 / Protein Synthesis Inhibitors; 0 / Vascular Endothelial Growth Factor A; 0 / vascular endothelial growth factor A, mouse; EC 2.7.10.1 / Receptor, TIE-2; F8VB5M810T / Tetracycline
  • [Other-IDs] NLM/ PMC1501179
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30. Hall WA, Doolittle ND, Daman M, Bruns PK, Muldoon L, Fortin D, Neuwelt EA: Osmotic blood-brain barrier disruption chemotherapy for diffuse pontine gliomas. J Neurooncol; 2006 May;77(3):279-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients presented for a median duration of 6 weeks with increased intracranial pressure, long tract signs, diplopia, ataxia, and nausea/vomiting.
  • Two patients had biopsies that showed an astrocytoma and an anaplastic astrocytoma.

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  • (PMID = 16314949.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS33618; United States / NINDS NIH HHS / NS / NS34608; United States / NINDS NIH HHS / NS / NS44687
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; YL5FZ2Y5U1 / Methotrexate
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31. Popple RA, Griffith HR, Sawrie SM, Fiveash JB, Brezovich IA: Implementation of talairach atlas based automated brain segmentation for radiation therapy dosimetry. Technol Cancer Res Treat; 2006 Feb;5(1):15-21
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  • We demonstrated the utility of Brains2DICOM using a test case, a 34-year-old man with diffuse astrocytoma treated with three-dimensional conformal radiotherapy.
  • This method will facilitate the acquisition of data necessary for the development of normal tissue complication probability (NTCP) models that assess the probability of cognitive complications secondary to radiotherapy for intracranial and head and neck neoplasms.
  • [MeSH-minor] Adult. Anatomy, Artistic. Astrocytoma / radiotherapy. Humans. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Male. Medical Illustration. Neural Networks (Computer). Software

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  • (PMID = 16417398.001).
  • [ISSN] 1533-0346
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Markia B, Gyorsok Z, Kordás M, Bognár L: [Pediatric intraventricular tumors]. Ideggyogy Sz; 2008 Nov 30;61(11-12):371-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These tumors growing in the ventricular system cause hydrocephalus in most of the cases, the presenting symptoms are the signs of raised intracranial pressure.
  • [MeSH-minor] Adolescent. Astrocytoma / diagnosis. Astrocytoma / surgery. Carcinoma / diagnosis. Carcinoma / surgery. Cerebrospinal Fluid Pressure. Child. Child, Preschool. Craniopharyngioma / diagnosis. Craniopharyngioma / surgery. Ependymoma / diagnosis. Ependymoma / surgery. Female. Glioma / diagnosis. Glioma / surgery. Humans. Hungary. Hydrocephalus / etiology. Hydrocephalus / physiopathology. Hydrocephalus / surgery. Infant. Magnetic Resonance Imaging. Male. Papilloma / diagnosis. Papilloma / surgery. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 19070311.001).
  • [ISSN] 0019-1442
  • [Journal-full-title] Ideggyógyászati szemle
  • [ISO-abbreviation] Ideggyogy Sz
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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33. Salunke P, Badhe P, Sharma A: Cerebellar glioblastoma multiforme with non-contiguous grade 2 astrocytoma of the temporal lobe in the same individual. Neurol India; 2010 Jul-Aug;58(4):651-3
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  • [Title] Cerebellar glioblastoma multiforme with non-contiguous grade 2 astrocytoma of the temporal lobe in the same individual.
  • We report a unique occurrence of such a combination in a 50-year-old man who presented with features of elevated intracranial pressure, ataxia and vertigo.
  • Histopathology revealed grade II astrocytoma in the temporal lobe and glioblastoma multiforme in the cerebellum.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Glioblastoma / complications. Temporal Lobe / pathology

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  • (PMID = 20739816.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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34. Grahovac G, Tomac D, Lambasa S, Zoric A, Habek M: Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir (Wien); 2009 Jun;151(6):653-7
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  • Most result from de-differentiation from low grade astrocytoma (secondary glioblastoma) or can develop de novo (primary glioblastoma).
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Cerebellum / pathology. Cerebellum / radiography. Cerebellum / surgery. Fatal Outcome. Female. Fourth Ventricle / pathology. Fourth Ventricle / surgery. Headache / etiology. Humans. Hydrocephalus / etiology. Intracranial Hypertension / etiology. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Neurosurgical Procedures / methods. Reoperation. Tomography, X-Ray Computed. Vomiting / etiology

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  • (PMID = 19319469.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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35. Essig M, Rohrer M, Giesel F, Tüttenberg J, Weber MA, Michaely H, Gerigk L, Voth M: Human brain tumor imaging with a protein-binding MR contrast agent: initial experience. Eur Radiol; 2010 Jan;20(1):218-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this report we present the first clinical experience with gadofosveset in enhancing intracranial tumors.
  • Ten patients with different intracranial tumors were examined with a standard dose (0.03 mmol/kg) of gadofosveset compared with a standard dose (0.1 mmol/kg) of conventional GBCA.
  • In one nonenhancing low grade astrocytoma an enhancing nodule became visible only 5 h after gadofosvesest injection.
  • As shown in this initial report, contrast-enhanced intracranial tumor imaging is possible with the protein-binding blood pool agent gadofosveset.

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  • [Cites] Curr Rheumatol Rep. 2006 Apr;8(2):151-7 [16569375.001]
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  • (PMID = 19672603.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Contrast Media; 0 / Organometallic Compounds; AU0V1LM3JT / Gadolinium; XM33Q67UVH / gadofosveset trisodium
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36. Hon SF, Wong GK, Zhu XL, Ng HK, Sin NC, Poon WS: Surgical treatment of a neonate with refractory seizures secondary to congenital giant cell astrocytoma: case report and literature review. Hong Kong Med J; 2006 Jun;12(3):222-4
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  • [Title] Surgical treatment of a neonate with refractory seizures secondary to congenital giant cell astrocytoma: case report and literature review.
  • They account for 0.5% to 1.9% of intracranial tumours in childhood and have an incidence of 0.34 per million live births.
  • Most congenital brain tumours are neuro-ectodermal tumours and medulloblastomas; giant cell astrocytoma and other tuberous sclerosis-related tumours are rare.
  • Surgical resection was performed successfully and pathology revealed the tumour to be a giant cell astrocytoma.

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  • (PMID = 16760552.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anticonvulsants
  • [Number-of-references] 8
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37. Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA: Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res; 2006 Sep 15;66(18):9054-64
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  • We studied vasculogenic and nonvasculogenic intracranial murine gliomas.
  • Hypoxia, observed with ectopic s.c. murine tumors at levels approximating that of intracranial human glioblastoma, interacted with tumor-secreted SDF-1 to expand engrafted vascular progenitor differentiated phenotypes to include pericytes as well as endothelium.
  • In contrast, less hypoxic orthotopic intracranial murine gliomas contained only marrow-derived endothelium without marrow-derived pericytes.
  • [MeSH-minor] Animals. Astrocytoma / blood supply. Astrocytoma / metabolism. Astrocytoma / secretion. Bone Marrow Cells / pathology. Chemokine CXCL12. Endothelial Cells / metabolism. Endothelial Cells / pathology. Mice. Mice, Inbred C57BL. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / pathology. Receptor, Epidermal Growth Factor / metabolism. Stem Cells / pathology. Vascular Endothelial Growth Factor A / biosynthesis. Vascular Endothelial Growth Factor A / secretion

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  • (PMID = 16982747.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / K08 HL071938; United States / NINDS NIH HHS / NS / NS41571; United States / NCI NIH HHS / CA / P01 CA69246; United States / NCI NIH HHS / CA / R01 CA85139
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CXCL12 protein, human; 0 / Chemokine CXCL12; 0 / Chemokines, CXC; 0 / Cxcl12 protein, mouse; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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38. Sharma MS, Kondziolka D, Khan A, Kano H, Niranjan A, Flickinger JC, Lunsford LD: Radiation tolerance limits of the brainstem. Neurosurgery; 2008 Oct;63(4):728-32; discussion 732-3
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  • METHODS: Thirty-eight patients (39 lesions) with intra-axial brainstem astrocytomas or vascular malformations underwent gamma knife surgery during a 6-year interval.
  • [MeSH-major] Astrocytoma / surgery. Brain Stem / radiation effects. Brain Stem Neoplasms / surgery. Ganglioglioma / surgery. Nervous System Diseases / etiology. Radiation Injuries / etiology. Radiosurgery / adverse effects
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Child, Preschool. Dose-Response Relationship, Radiation. Female. Humans. Intracranial Arteriovenous Malformations / surgery. Male. Middle Aged. Retrospective Studies. Time Factors. Young Adult

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  • (PMID = 18981883.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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39. Makidono A, Kobayashi N, Saida Y, Manabe A, Kawamori J, Suzuki K: Metachronous gliomas following cranial irradiation for mixed germ cell tumors. Childs Nerv Syst; 2009 Jun;25(6):713-8
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  • However, metachronous intracranial double tumors induced by radiation therapy are extremely rare.
  • In here, we report a case of metachronous different gliomas including astrocytoma and glioblastoma following irradiation therapy after 41 and 46 months, respectively.
  • [MeSH-major] Astrocytoma / etiology. Brain Neoplasms / radiotherapy. Cranial Irradiation / adverse effects. Glioblastoma / etiology. Neoplasms, Germ Cell and Embryonal / radiotherapy. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 19247675.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Neuloh G, Schramm J: Are there false-negative results of motor evoked potential monitoring in brain surgery? Cent Eur Neurosurg; 2009 Nov;70(4):171-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / pathology. Astrocytoma / surgery. Brain Edema / etiology. Child. Child, Preschool. Electric Stimulation. Female. Glioblastoma / pathology. Glioblastoma / surgery. Hemispherectomy. Humans. Male. Middle Aged. Paresis / etiology. Postoperative Complications / etiology. Prospective Studies. Treatment Outcome. Vasospasm, Intracranial / complications. Young Adult

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  • [Copyright] Georg Thieme Verlag KG Stuttgart * New York.
  • (PMID = 19851956.001).
  • [ISSN] 1868-4912
  • [Journal-full-title] Central European neurosurgery
  • [ISO-abbreviation] Cent Eur Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article
  • [Publication-country] Germany
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41. Raz E, Antonelli M, Pichierri A, Consoli A, Giangaspero F, Fiorelli M: 35 year-old man with falcine tumor. Brain Pathol; 2010 Sep;20(5):987-8
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  • Given the localization, microscopic features were diagnostic of primary intracranial solitary leptomeningeal astrocytoma (PLA), WHO grade 3.

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  • (PMID = 20695870.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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42. Howes TL, Buatti JM, Kirby PA, Carlisle TL, Ryken TC: Radiation induced adult medulloblastoma: a case report. J Neurooncol; 2006 Nov;80(2):191-4
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  • Adult medulloblastoma is a rare intracranial tumor.
  • Our patient is a 61 year old woman treated with cranial irradiation 15 years previously for a low grade astrocytoma in the left posterior temporal lobe that was recently diagnosed with medulloblastoma in the right cerebellum.
  • [MeSH-minor] Astrocytoma / radiotherapy. Brain Neoplasms / radiotherapy. Craniotomy. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Temporal Lobe / pathology

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  • (PMID = 16710747.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Biyani N, Silbiger A, Ben-Ari J, Constantini S: Postoperative brain stem tension pneumocephalus causing transient locked-in syndrome. Pediatr Neurosurg; 2007;43(5):414-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, transformation of postoperative pneumocephalus into tension pneumocephalus (symptomatic intracranial air) is a rather rare phenomenon.
  • We hereby report on a patient who developed brain-stem tension pneumocephalus in the early postoperative period after posterior fossa craniotomy for an exophytic brainstem astrocytoma, operated in the prone position.

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17786010.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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44. Makino K, Nakamura H, Yano S, Kuratsu J, Kumamoto Brain Tumor Group: Population-based epidemiological study of primary intracranial tumors in childhood. Childs Nerv Syst; 2010 Aug;26(8):1029-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Population-based epidemiological study of primary intracranial tumors in childhood.
  • The aim of this study was to determine the epidemiology of childhood primary intracranial tumors in Kumamoto Prefecture, Japan.
  • METHODS: We surveyed 210 patients younger than 15 years who were diagnosed with primary intracranial tumors between 1989 and 2008; 159 (75.7%) of the tumors were confirmed microscopically.
  • The most common tumor was astrocytoma (35.7%) with an annual incidence rate of 13.2 per million, followed by germ cell tumor (14.3%, 5.0 per million), craniopharyngioma (10.5%, 3.8 per million), medulloblastoma (10.0%, 3.7 per million), and ependymoma (4.8%, 1.5 per million).
  • CONCLUSIONS: In this Kumamoto survey, the incidence rate of primary intracranial tumors in children was similar to that in Western countries.

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  • (PMID = 20349186.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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45. Maeda M, Namikawa K, Kobayashi I, Ohba N, Takahara Y, Kadono C, Tanaka A, Kiyama H: Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system. Brain Res; 2006 Apr 7;1081(1):34-43
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  • [Title] Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system.
  • The aim of this study was to establish a novel adenovirus-based gene therapy system targeting astrocytoma.
  • For this purpose, the Cre recombinase (Cre)/loxP system together with the astrocytoma-specific promoter for GFAP were used.
  • Furthermore, a combination of AxGFAPNCre/AxCALGLTK and intraperitoneal GCV injection significantly regressed intracranial C6 gliomas in the rat striatum and prolonged the survival time compared with control rats.
  • The present results indicate that this cell-type-specific gene therapy using a Cre/loxP adenovirus system is both operational and effective, at least against astrocytoma.
  • [MeSH-major] Astrocytoma / therapy. Extracellular Matrix Proteins / therapeutic use. Genetic Therapy. Integrases / therapeutic use. Protein-Lysine 6-Oxidase / therapeutic use. Viral Proteins / therapeutic use

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  • (PMID = 16529724.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / Viral Proteins; 149137-54-2 / Lox protein, mouse; EC 1.4.3.13 / Protein-Lysine 6-Oxidase; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases
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46. Miura FK, Alves MJ, Rocha MC, da Silva R, Oba-Shinjo SM, Marie SK: Xenograft transplantation of human malignant astrocytoma cells into immunodeficient rats: an experimental model of glioblastoma. Clinics (Sao Paulo); 2010 Mar;65(3):305-9
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  • [Title] Xenograft transplantation of human malignant astrocytoma cells into immunodeficient rats: an experimental model of glioblastoma.
  • INTRODUCTION: Astrocytic gliomas are the most common intracranial central nervous system neoplasias, accounting for about 60% of all primary central nervous system tumors.
  • OBJECTIVE: To develop an experimental malignant astrocytoma model with the characteristics of the human tumor.
  • METHOD: Primary cells from subcutaneous xenograft tumors produced with malignant astrocytoma U87MG cells were inoculated intracerebrally by stereotaxis into immunosuppressed (athymic) Rowett rats.
  • CONCLUSION: A malignant astrocytoma intracerebral xenograft model with poorly invasive behavior was achieved in athymic Rowett rats.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Glioblastoma / pathology. Immunocompromised Host

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  • (PMID = 20360922.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC2845772
  • [Keywords] NOTNLM ; Athymic Rowett rats / Brain tumor / Experimental model / U87MG cells
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47. Isaacs H: Fetal brain tumors: a review of 154 cases. Am J Perinatol; 2009 Jun;26(6):453-66
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  • Next was astrocytoma followed by craniopharyngioma, primitive neuroectodermal tumor, choroid plexus papilloma, meningeal tumors, and ependymoma.
  • The most common presenting findings were macrocephaly and an intracranial mass.
  • Many tumors were inoperable as they occupied much of the intracranial cavity and involved large areas of the brain.
  • [MeSH-minor] Astrocytoma / epidemiology. Craniopharyngioma / epidemiology. Ependymoma / epidemiology. Female. Humans. Meningioma / epidemiology. Neuroectodermal Tumors, Primitive / epidemiology. Papilloma, Choroid Plexus / epidemiology. Pregnancy. Retrospective Studies. Stillbirth / epidemiology. Survival Rate. Teratoma / epidemiology

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  • (PMID = 19396744.001).
  • [ISSN] 1098-8785
  • [Journal-full-title] American journal of perinatology
  • [ISO-abbreviation] Am J Perinatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 101
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48. Ferroir JP, Marro B, Belkacemi Y, Stilhart B, Schlienger M: [Cerebral infarction related to intracranial radiation arteritis twenty-four years after encephalic radiation therapy]. Rev Neurol (Paris); 2007 Jan;163(1):96-8
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  • [Title] [Cerebral infarction related to intracranial radiation arteritis twenty-four years after encephalic radiation therapy].
  • We report a case of a resolutive late cerebral ischemic event, related to radiation induced vasculopathy of the left posterior cerebral artery, documented by MRI, situated in the irradiated volume 24 years before, for an astrocytome with malignant potential.
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / radiotherapy. Brain Neoplasms / radiotherapy. Humans. Male. Radiotherapy / adverse effects. Time Factors

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  • (PMID = 17304179.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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49. Della Puppa A, Zustovich F, Gardiman M, Manara R, Cecchin D, Scienza R: Haemorrhagic presentation of low-grade glioma in adults. Acta Neurochir (Wien); 2007 Nov;149(11):1151-5; discussion 1155
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  • Intracranial bleeding is rare in patients with low-grade gliomas, above all in adult population.
  • [MeSH-major] Astrocytoma / diagnosis. Basal Ganglia Diseases / diagnosis. Basal Ganglia Hemorrhage / etiology. Brain Neoplasms / diagnosis. Magnetic Resonance Imaging. Positron-Emission Tomography. Putaminal Hemorrhage / etiology. Tomography, X-Ray Computed

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  • (PMID = 17676407.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 22
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50. Ilhan A, Gartner W, Neziri D, Czech T, Base W, Hörl WH, Wagner L: Angiogenic factors in plasma of brain tumour patients. Anticancer Res; 2009 Feb;29(2):731-6
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  • BACKGROUND: Angiopoiesis and angiopoietic growth factors are of considerable importance in the development and progression of intracranial tumours.
  • PATIENTS AND METHODS: Plasma samples of 78 patients suffering from various types of intracranial tumours (glioblastoma multiforme, GBM, n = 22; astrocytoma, n = 12; meningioma, n = 16; and intracranial metastasis, n = 28) were analysed.
  • RESULTS: Ang-2 plasma concentration in GBM patients was significantly lower when compared with that in patients with meningioma and intracranial metastasis.
  • Interestingly, VEGF plasma levels depended on the number of intracranial lesions, with significantly higher concentrations in patients with 3 or more lesions when compared with those with 2 or fewer lesions.
  • [MeSH-minor] Adult. Aged. Angiopoietin-2 / blood. Astrocytoma / blood. Astrocytoma / pathology. Enzyme-Linked Immunosorbent Assay. Female. Glioblastoma / blood. Glioblastoma / pathology. Humans. Male. Meningioma / blood. Meningioma / pathology. Middle Aged. Platelet-Derived Growth Factor / metabolism. Proto-Oncogene Proteins c-sis. Vascular Endothelial Growth Factor A / blood

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  • (PMID = 19331229.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Angiogenic Proteins; 0 / Angiopoietin-2; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / platelet-derived growth factor BB
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51. Müller-Forell W: [Neuroradiology of the intracranial visual pathway. Part II]. Radiologe; 2005 Nov;45(11):1043-55
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  • [Title] [Neuroradiology of the intracranial visual pathway. Part II].
  • Part 2 mainly presents intrinsic lesions as the most common brain tumors (astrocytoma of all grades, ependymoma), arising in the region of the visual pathway.
  • [MeSH-minor] Adult. Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Child. Ependymoma / diagnosis. Female. Hemangioma, Cavernous / diagnosis. Humans. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Middle Aged. Multiple Sclerosis / diagnosis. Sarcoidosis / diagnosis. Sturge-Weber Syndrome / diagnosis

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  • [Cites] Eur J Radiol. 2004 Feb;49(2):143-78 [14746935.001]
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  • [Cites] Radiologe. 2000 Nov;40(11):1090-7 [11147324.001]
  • (PMID = 16228165.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 17
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52. Romeike BF, Böckeler A, Kremmer E, Sommer P, Krick C, Grässer F: Immunohistochemical detection of dUTPase in intracranial tumors. Pathol Res Pract; 2005;201(11):727-32
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  • [Title] Immunohistochemical detection of dUTPase in intracranial tumors.
  • A hundred and twenty-seven human intracranial tumors, including 56 astrocytomas, 12 oligodendrogliomas, 8 oligoastrocytomas, 34 meningiomas, 7 ependymomas, and 10 metastatic carcinomas, were stained using the monoclonal rat anti-human dUTPase antibody (clone 3E6) with formalin-fixed and paraffin-embedded tissue.
  • Labeling indices for dUTPase, but not for Ki-67, showed significant differences between all 3 WHO grades of diffuse astrocytomas.
  • It proved particularly useful for the evaluation of diffuse astrocytomas.
  • [MeSH-minor] Astrocytoma / enzymology. Astrocytoma / immunology. Astrocytoma / pathology. Cell Nucleus / enzymology. Cell Nucleus / immunology. Cell Proliferation. Ependymoma / enzymology. Ependymoma / immunology. Ependymoma / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Meningioma / enzymology. Meningioma / immunology. Meningioma / pathology. Oligodendroglioma / enzymology. Oligodendroglioma / immunology. Oligodendroglioma / pathology. Paraffin Embedding. World Health Organization

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [ErratumIn] Pathol Res Pract. 2006;202(1):65
  • (PMID = 16325515.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; EC 3.6.1.- / Pyrophosphatases; EC 3.6.1.23 / dUTP pyrophosphatase
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53. Dashti SR, Robinson S, Rodgers M, Cohen AR: Pineal region giant cell astrocytoma associated with tuberous sclerosis: case report. J Neurosurg; 2005 Apr;102(3 Suppl):322-5
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  • [Title] Pineal region giant cell astrocytoma associated with tuberous sclerosis: case report.
  • Cortical tubers and subependymal nodules are the characteristic intracranial lesions of tuberous sclerosis.
  • Subependymal giant cell astrocytomas, typically located adjacent to the foramen of Monro, can enlarge and cause symptomatic ventricular obstruction.
  • Pathological examination showed a giant cell astrocytoma.
  • To the authors' knowledge, this is the first reported case of tuberous sclerosis associated with a giant cell astrocytoma of the pineal region.
  • [MeSH-major] Astrocytoma / complications. Astrocytoma / surgery. Pinealoma / complications. Pinealoma / surgery. Tuberous Sclerosis / complications

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  • (PMID = 15881760.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Fernandez A, Karavitaki N, Ansorge O, Fazal-Sanderson V, Wass JA: Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? Pituitary; 2008;11(3):325-30
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  • [Title] Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation?
  • Insulin-like growth factor type I (IGF-I) is an important promoter in the tumorigenesis of several extracranial and intracranial neoplasms.
  • We report the case of a 28-year-old man who presented simultaneously with acromegaly and an anaplastic astrocytoma, which had rapidly progressed from a low-grade astrocytoma.
  • The coexistence of systemic IGF-I hypersecretion with a quick progression in the histopathological grade of the astrocytoma raises the compelling question of whether the clinical behavior of the astrocytic tumor was influenced by the acromegalic status.
  • The role of IGF-I signaling in the pathogenesis of astrocytic-cell tumors and the experience with therapeutic strategies addressing this pathway in astrocytomas are also discussed.
  • [MeSH-major] Acromegaly / complications. Astrocytoma / complications. Brain Neoplasms / complications

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  • (PMID = 18000757.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ergolines; 0 / Peptides, Cyclic; 0G3DE8943Y / lanreotide; 51110-01-1 / Somatostatin; 67763-96-6 / Insulin-Like Growth Factor I; LL60K9J05T / cabergoline
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55. Di X: Multiple brain tumor nodule resections under direct visualization of a neuronavigated endoscope. Minim Invasive Neurosurg; 2007 Aug;50(4):227-32
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  • METHODS: A 0-degree, 4-mm rigid endoscopes (DCI; Storz and Co., Tuttlingen, Germany) and Voyager SX navigation system by Z-KAT (Marconi, USA) were used for both cases, a 32-year-old woman with multiple hemangioblastomas and a 46-year-old man with two recurrent astrocytomas.
  • For both posterior fossa tumors, an entry point on the skull was identified using "virtual endoscopy" to visualize the intracranial anatomy and lesions.
  • CONCLUSION: The neuronavigated endoscope coordinates of the tip of endoscope, and the trajectory of targets, provide both 3D orientation and direct endoscopic visualization simultaneously, and present with the unique feature for solely endoscopic minimally invasive procedures, especially for multiple intracranial lesions.
  • [MeSH-minor] Adult. Astrocytoma / pathology. Astrocytoma / surgery. Cerebellum / pathology. Cerebellum / physiopathology. Cerebellum / surgery. Endoscopes / standards. Female. Hemangioblastoma / pathology. Hemangioblastoma / surgery. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures / instrumentation. Minimally Invasive Surgical Procedures / methods. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Treatment Outcome

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  • (PMID = 17948182.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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56. Maranhão ET, Maranhão-Filho P, Lima MA, Vincent MB: Can clinical tests detect early signs of monohemispheric brain tumors? J Neurol Phys Ther; 2010 Sep;34(3):145-9
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  • Despite the availability of sophisticated neuroimaging methods, to identify intracranial tumors the clinical recognition of associated subtle motor deficits is important for practice.
  • Even without apparent motor deficits, when present, these signs suggest that comprehensive investigation for intracranial neoplams should be undertaken.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Glioblastoma / diagnosis. Neurologic Examination / methods

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  • (PMID = 20799429.001).
  • [ISSN] 1557-0584
  • [Journal-full-title] Journal of neurologic physical therapy : JNPT
  • [ISO-abbreviation] J Neurol Phys Ther
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / / ; United Kingdom / Wellcome Trust / /
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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57. Scheinemann K, Bartels U, Huang A, Hawkins C, Kulkarni AV, Bouffet E, Tabori U: Survival and functional outcome of childhood spinal cord low-grade gliomas. Clinical article. J Neurosurg Pediatr; 2009 Sep;4(3):254-61
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  • Epidemiological and clinical data in this cohort were different than in patients with other spinal tumors and strikingly similar to data from pediatric patients with intracranial LGGs.
  • Histological testing revealed a Grade I astrocytoma in 86% of tumors.
  • The similarities between spinal and intracranial LGGs in pediatric patients showing excellent survival but high morbidity suggest that a less aggressive approach may be the preferable treatment option for these patients.

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  • (PMID = 19772410.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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58. Lyons MK: Pilocytic astrocytoma with spontaneous intracranial hemorrhages in an elderly adult. Clin Neurol Neurosurg; 2007 Jan;109(1):76-80
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  • [Title] Pilocytic astrocytoma with spontaneous intracranial hemorrhages in an elderly adult.
  • Pilocytic astrocytomas are relatively uncommon tumors found predominantly in the pediatric population.
  • This is a report of a 75-year-old man presenting with two spontaneous intracranial hemorrhages and subsequent resection of a pilocytic astrocytoma.
  • A review of the literature summarizes the current field of knowledge of adult pilocytic astrocytomas in the setting of intracranial hemorrhage.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Intracranial Hemorrhages / etiology

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  • (PMID = 16621238.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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59. Beetz C, Bergner S, Brodoehl S, Brodhun M, Ewald C, Kalff R, Krüger J, Patt S, Kiehntopf M, Deufel T: Outcome-based profiling of astrocytic tumours identifies prognostic gene expression signatures which link molecular and morphology-based pathology. Int J Oncol; 2006 Nov;29(5):1183-91
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  • Astrocytomas are intracranial malignancies for which invasive growth and high motility of tumour cells preclude total resection; the tumours usually recur in a more aggressive and, eventually, lethal form.
  • [MeSH-major] Astrocytoma / mortality. Biomarkers, Tumor / analysis. Brain Neoplasms / mortality. Gene Expression Profiling. Genes, Neoplasm / genetics

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  • (PMID = 17016650.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Neoplasm
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60. Shah M, Park HJ, Gohari AR, Bhatti MT: Loss of myelinated retinal nerve fibers from chronic papilledema. J Neuroophthalmol; 2008 Sep;28(3):219-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An intracranial pilocytic astrocytoma was diagnosed in a 13-year-old boy after he presented with headaches and visual disturbances.
  • [MeSH-major] Astrocytoma / complications. Hypothalamic Neoplasms / complications. Nerve Fibers, Myelinated / pathology. Optic Atrophy / etiology. Papilledema / complications

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  • (PMID = 18769289.001).
  • [ISSN] 1536-5166
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Lee CS, Huh JS, Sim KB, Kim YW: Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. Childs Nerv Syst; 2009 Jan;25(1):125-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma.
  • INTRODUCTION: Massive intracranial hemorrhage is a very rare initial presentation of cerebellar pilocytic astrocytomas.
  • There are no reports in the medical literature on a cerebellar pilocytic astrocytoma presenting with intratumor bleeding (ITB), subarachnoid hemorrhage (SAH), and subdural hematoma (SDH).
  • Microscopic examination of tissue sections revealed a pilocytic astrocytoma.
  • [MeSH-major] Astrocytoma / complications. Cerebellar Neoplasms / complications. Hematoma, Subdural / etiology. Subarachnoid Hemorrhage / etiology

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  • (PMID = 18629510.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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62. El-Gaidi MA, Eissa EM: Infantile intracranial neoplasms: characteristics and surgical outcomes of a contemporary series of 21 cases in an Egyptian referral center. Pediatr Neurosurg; 2010;46(4):272-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infantile intracranial neoplasms: characteristics and surgical outcomes of a contemporary series of 21 cases in an Egyptian referral center.
  • OBJECTIVE: To investigate the demographic, clinical, radiological, pathological and surgical features and outcomes of infantile intracranial neoplasms, the second most common neoplasm in infants.
  • RESULTS: Out of 451 patients with primary intracranial neoplasms (age 0-14 years), 21 infants (<1 year) underwent surgery, representing 4.7% of total cases.
  • The most common tumor was choroid plexus papilloma (23.8%), followed by teratoma (19%) then astrocytoma and ependymoma (14.3% each).
  • CONCLUSION: Although the prognosis for infantile intracranial neoplasms is worse than for older children, an overall promising outcome with low operative morbidity and mortality was achieved using gross total excision and appropriate adjuvant chemotherapy as part of a multidisciplinary approach.
  • [MeSH-minor] Adolescent. Astrocytoma / drug therapy. Astrocytoma / mortality. Astrocytoma / surgery. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Egypt / epidemiology. Ependymoma / drug therapy. Ependymoma / mortality. Ependymoma / surgery. Female. Humans. Infant. Infant, Newborn. Male. Medulloblastoma / drug therapy. Medulloblastoma / mortality. Medulloblastoma / surgery. Morbidity. Neurilemmoma / drug therapy. Neurilemmoma / mortality. Neurilemmoma / surgery. Prognosis. Quality of Life. Referral and Consultation / statistics & numerical data. Retrospective Studies. Teratoma / drug therapy. Teratoma / mortality. Teratoma / surgery

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21160236.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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63. Zhi F, Chen X, Wang S, Xia X, Shi Y, Guan W, Shao N, Qu H, Yang C, Zhang Y, Wang Q, Wang R, Zen K, Zhang CY, Zhang J, Yang Y: The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma. Eur J Cancer; 2010 Jun;46(9):1640-9
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  • [Title] The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma.
  • In the present study, the miRNA expression profile was examined in astrocytoma, a malignant and prevalent intracranial tumour in adults.
  • METHODS: We screened the expression profile of 200 miRNAs in a training sample set consisting of 84 astrocytoma samples and 20 normal adjacent tissue (NAT) samples using the method of stem-loop quantitative RT-PCR.
  • The significantly altered miRNAs were validated in another independent sample set consisting of 40 astrocytoma samples and 40 NAT samples.
  • The correlation of the miRNA levels with survival in astrocytoma samples was estimated by performing Kaplan-Meier survival analysis and univariate/multivariate Cox proportional hazard regression analysis.
  • RESULTS: After a two-phase selection and validation process, seven miRNAs were found to have a significantly different expression profile in astrocytoma samples upon comparison to the NAT samples.
  • The down-regulation of hsa-miR-137 in astrocytomas was shown to be associated with advanced clinical stages of this disease.
  • CONCLUSIONS: Our results suggest a great potential for the use of miRNA profiling as a powerful diagnostic and prognostic marker in defining the signature of astrocytomas and in predicting the post-surgical outcome.
  • [MeSH-major] Astrocytoma / metabolism. Biomarkers, Tumor / metabolism. Brain Neoplasms / metabolism. MicroRNAs / metabolism

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20219352.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MIRN106 microRNA, human; 0 / MIRN21 microRNA, human; 0 / MIrn181 microRNA, human; 0 / MicroRNAs
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64. Eyenga VC, Ngah JE, Atangana R, Etom E, Ngowe MN, Bassong Y, Oyono JL, Sosso M: [Central nervous system tumours in Cameroon: histopathology and demography]. Sante; 2008 Jan-Mar;18(1):39-42
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  • In all, 74.9% (n=173) of the tumours were intracranial and 25.1% (n=58) spinal; 167 (72.3%) were the primary site and 64 (27.7%) metastatic.
  • Meningiomas were the most frequent tumours in our series, with 56 (24.2%) cases, followed by 42 astrocytomas (18.1%).
  • Meningiomas were the most frequent tumors in adults while astrocytomas were more prevalent in children.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Astrocytoma / epidemiology. Astrocytoma / pathology. Brain / pathology. Cameroon. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Meninges / pathology. Middle Aged. Neoplasm Staging

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  • (PMID = 18684690.001).
  • [ISSN] 1157-5999
  • [Journal-full-title] Santé (Montrouge, France)
  • [ISO-abbreviation] Sante
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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65. Kitagawa M, Sato T, Ishizaki R, Saiki M: [Resolution of migraine with aura by removing pilocytic astrocytoma of the occipital lobe]. No Shinkei Geka; 2006 Jan;34(1):59-64
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  • [Title] [Resolution of migraine with aura by removing pilocytic astrocytoma of the occipital lobe].
  • Here we report a case of pilocytic astrocytoma in the right occipital lobe presenting as migraine with aura.
  • Total removal of the tumor (pilocytic astrocytoma, WHO grade 1) relieved her migraine completely.
  • But this is the first report of occipital pilocytic astrocytoma presenting as migraine with aura.
  • As for other brain tumors manifesting migraine, all of them had focal neurological deficits or symptoms associated with increased intracranial pressure (ICP).
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Migraine with Aura / etiology. Occipital Lobe
  • [MeSH-minor] Adult. Female. Humans. Intracranial Hypertension / etiology


66. Goswami C, Chatterjee U, Sen S, Chatterjee S, Sarkar S: Expression of cytokeratins in gliomas. Indian J Pathol Microbiol; 2007 Jul;50(3):478-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All the cases were diagnosed as primary or metastatic intracranial tumors.
  • [MeSH-minor] Astrocytoma / diagnosis. Astrocytoma / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Glial Fibrillary Acidic Protein / metabolism. Glioblastoma / diagnosis. Glioblastoma / metabolism. Humans. Immunohistochemistry. Oligodendroglioma / diagnosis. Oligodendroglioma / metabolism

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  • (PMID = 17883112.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 68238-35-7 / Keratins
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67. Yoshikawa G, Kawamoto S, Yakou K, Tsutsumi K: Massive intracranial hemorrhage associated with pleomorphic xanthoastrocytoma--case report. Neurol Med Chir (Tokyo); 2010;50(3):220-3
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  • [Title] Massive intracranial hemorrhage associated with pleomorphic xanthoastrocytoma--case report.
  • A 60-year-old woman with a history of intermittent headaches and frequent seizures for 30 years presented with a massive intracranial hematoma in the left medial temporal lobe with thick subarachnoid hemorrhage.
  • [MeSH-major] Aneurysm, False / etiology. Aneurysm, Ruptured / etiology. Astrocytoma / complications. Brain Neoplasms / complications. Hematoma, Subdural, Intracranial / etiology. Subarachnoid Hemorrhage / etiology

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  • (PMID = 20339272.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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68. Mehrazin M, Yavari P: Morphological pattern and frequency of intracranial tumors in children. Childs Nerv Syst; 2007 Feb;23(2):157-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphological pattern and frequency of intracranial tumors in children.
  • OBJECTIVE: To determine the age, sex, location, and histologic diagnosis of intracranial tumors in children less than 15 years of age.
  • The mixed five most common histological diagnoses in patients were astrocytoma (40.4%), followed by medulloblastoma (18.4%), ependymoma (10.5%), craniopharyngioma (8.8%), and meningioma (4.2%).
  • Astrocytoma occurred mostly in children aged 5-15 years (87%).
  • Astrocytoma was the first most common brain tumor in all age groups.

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  • (PMID = 16953459.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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69. Raju GP, Urion DK, Sahin M: Neonatal subependymal giant cell astrocytoma: new case and review of literature. Pediatr Neurol; 2007 Feb;36(2):128-31
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  • [Title] Neonatal subependymal giant cell astrocytoma: new case and review of literature.
  • Subependymal giant cell astrocytomas are one of the three major intracranial lesions found in tuberous sclerosis complex.
  • Subependymal giant cell astrocytomas are typically slow-growing tumors of mixed glioneuronal lineage which can become aggressive and cause obstructive hydrocephalus usually in older children and adolescents.
  • Neonatal subependymal giant cell astrocytomas are extremely rare, and their natural history and prognosis are poorly understood.
  • This report investigates an extremely large neonatal subependymal giant cell astrocytoma which was initially identified in utero at 19 weeks of gestation in a high-risk pregnancy with no family history of tuberous sclerosis complex.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Magnetic Resonance Imaging


70. Oka F, Yamashita Y, Kumabe T, Tominaga T: Total resection of a hemorrhagic tectal pilocytic astrocytoma--case report. Neurol Med Chir (Tokyo); 2007 May;47(5):219-21
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  • [Title] Total resection of a hemorrhagic tectal pilocytic astrocytoma--case report.
  • A 21-year-old man presented with a hemorrhagic pilocytic astrocytoma of the tectal plate manifesting as sudden onset of severe headache, vertigo, nausea, and vomiting.
  • The histological diagnosis was pilocytic astrocytoma.
  • Tectal plate pilocytic astrocytoma is rarely associated with hemorrhage but should be considered in the differential diagnosis of intracranial hemorrhage with acute presentation.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / surgery. Brain Neoplasms / pathology. Brain Neoplasms / surgery. Intracranial Hemorrhages / etiology. Tectum Mesencephali

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  • (PMID = 17527049.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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71. Shibahara I, Kanamori M, Kumabe T, Endo H, Sonoda Y, Ogawa Y, Watanabe M, Tominaga T: Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma. Brain Tumor Pathol; 2009;26(1):1-5
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  • [Title] Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma.
  • The incidence of hemorrhagic onset in pilocytic astrocytoma and pilomyxoid astrocytoma, and the clinical and histological characteristics, were compared to other types of neuroepithelial tumors or nonhemorrhagic pilocytic astrocytoma by retrospective review of 445 consecutive neuroepithelial tumors treated at our institute.
  • Hemorrhagic onset was observed in 4 of 35 (11.4%) patients with pilocytic astrocytoma and pilomyxoid astrocytoma, with higher incidence than in glioblastoma (3.9%), anaplastic oligodendroglioma (7.7%), and anaplastic ependymoma (7.1%).
  • The hemorrhagic onset occurred in 2 patients with sporadic pilocytic astrocytoma, 1 with pilocytic astrocytoma associated with neurofibromatosis type 1, and 1 with pilomyxoid astrocytoma.
  • Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma is not as uncommon as was previously thought, so pilocytic astrocytoma or pilomyxoid astrocytoma should be considered in the differential diagnosis of patients with brain tumors manifesting as hemorrhagic onset.
  • [MeSH-major] Astrocytoma / complications. Astrocytoma / pathology. Brain Neoplasms / complications. Brain Neoplasms / pathology. Intracranial Hemorrhages / etiology. Intracranial Hemorrhages / pathology


72. Polin RS, Marko NF, Ammerman MD, Shaffrey ME, Huang W, Anderson FA Jr, Caputy AJ, Laws ER: Functional outcomes and survival in patients with high-grade gliomas in dominant and nondominant hemispheres. J Neurosurg; 2005 Feb;102(2):276-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: The goal of this study was to investigate survival and functional outcomes in patients with high-grade intracranial astrocytomas as a function of the location of the lesion in the dominant or nondominant hemisphere (DH and NDH, respectively), and to suggest management strategies for such patients based on these data.
  • METHODS: Data were collected from the Glioma Outcomes Project database, a longitudinal database of demographic, clinical, and outcome data for patients with high-grade intracranial gliomas.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Glioblastoma / surgery. Karnofsky Performance Status. Postoperative Complications / diagnosis

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  • (PMID = 15739555.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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73. Wang LW, Shiau CY, Chung WY, Wu HM, Guo WY, Liu KD, Ho DM, Wong TT, Pan DH: Gamma Knife surgery for low-grade astrocytomas: evaluation of long-term outcome based on a 10-year experience. J Neurosurg; 2006 Dec;105 Suppl:127-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma Knife surgery for low-grade astrocytomas: evaluation of long-term outcome based on a 10-year experience.
  • OBJECT: The authors report the long-term treatment results of Gamma Knife surgery (GKS) for patients with low-grade astrocytomas who underwent surgery at a single institution.
  • METHODS: A series of 21 patients (median age 20 years) with 25 intracranial low-grade astrocytomas (World Health Organization Grades I and II) were treated with GKS between 1993 and 2003.
  • CONCLUSIONS: Gamma Knife surgery provides durable long-term local tumor control with acceptable toxicity for some patients with highly selected low-grade astrocytomas.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / surgery. Brain Neoplasms / pathology. Brain Neoplasms / surgery. Radiosurgery

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  • (PMID = 18503345.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Blouw B, Haase VH, Song H, Bergers G, Johnson RS: Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene; 2007 Jul 5;26(31):4531-40
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  • We created malignant astrocytes with genetic deletions of the VHL gene and implanted them in subcutaneous and intracranial sites; these sites are respectively vessel poor and vessel-rich tissues.
  • However, when the same cells are grown in the vessel-rich intracranial environment, loss of VEGF expression reduces vascularization, but does not affect tumor growth.

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  • (PMID = 17297464.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA 100787; United States / NCI NIH HHS / CA / R01 CA100787; United States / NIDDK NIH HHS / DK / R03 DK062060; United States / NCI NIH HHS / CA / CA082515; United States / NIDDK NIH HHS / DK / K08 DK002668
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Vascular Endothelial Growth Factor A; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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75. Bellil S, Limaiem F, Mahfoudhi H, Bellil K, Chelly I, Mekni A, Jemel H, Khaldi M, Haouet S, Zitouna M, Kchir N: Descriptive epidemiology of childhood central nervous system tumours in Tunisia. experience of a single institution over a 15-year period (1990-2004). Pediatr Neurosurg; 2008;44(5):382-7
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  • RESULTS: There were 488 primary and 4 secondary tumours; 426 (86.6%) were intracranial and 66 (13.4%) were intraspinal.
  • Of the 426 intracranial tumours, 214 (50.24%) were supratentorial and 212 (49.76%) were infratentorial.
  • The most common tumour found in our series was astrocytoma (38%), followed by medulloblastoma (16.2%), then ependymoma (6.9%), cystic tumours (6.3%) and craniopharyngioma (5.3%).

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18703884.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
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76. Niculescu CE, Stănescu L, Popescu M, Niculescu D: Supratentorial pilocytic astrocytoma in children. Rom J Morphol Embryol; 2010;51(3):577-80
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  • [Title] Supratentorial pilocytic astrocytoma in children.
  • The authors describe the case of a child aged 2 years and 4 months with increased intracranial pressure, symptomatology accompanied by rapid deterioration of general condition.
  • Histopathological examination revealed the typical grade I pilocytic astrocytoma.
  • [MeSH-major] Astrocytoma / pathology. Supratentorial Neoplasms / pathology

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  • (PMID = 20809042.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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77. Bodey B, Bodey V, Siegel SE: Expression in childhood primary brain tumors of NY-ESO-1, a cancer/testis antigen: an immunohistochemical study. In Vivo; 2008 Jan-Feb;22(1):83-7
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  • The expression of NY-ESO-1 in intracranial brain tumors including astrocytomas (ASTRs) and medulloblastomas (MEDs)/primitive neuroectodermal tumors (PNETs) was examined since the expression of NY-ESO-1 has only previously been explored in depth in neuroblastomas.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Astrocytoma / metabolism. Biomarkers, Tumor / metabolism. Brain Neoplasms / metabolism. Medulloblastoma / metabolism. Membrane Proteins / metabolism


78. Chumbalkar VC, Subhashini C, Dhople VM, Sundaram CS, Jagannadham MV, Kumar KN, Srinivas PN, Mythili R, Rao MK, Kulkarni MJ, Hegde S, Hegde AS, Samual C, Santosh V, Singh L, Sirdeshmukh R: Differential protein expression in human gliomas and molecular insights. Proteomics; 2005 Mar;5(4):1167-77
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  • Gliomas are the most common of the primary intracranial tumors with astrocytomas constituting about 40%.
  • Using clinically and histologically assessed astrocytomas, we have studied their protein profiles using a two-dimensional gel electrophoresis-mass spectrometry approach and identified differentially expressed proteins which may be useful molecular indicators to understand these tumors.
  • Examination of the protein profiles of 27 astrocytoma samples of different grades revealed 72 distinct, differentially expressed proteins belonging to various functional groups such as cytoskeleton and intermediate filament proteins, heat shock proteins (HSPs), enzymes and regulatory proteins.
  • Based on the consistency of their differential expression, 29 distinct proteins could be short-listed and may have a role in the pathology of astrocytomas.
  • Some were found to be differentially expressed in both Grade III and IV astrocytomas while others were associated with a particular grade.
  • [MeSH-major] Astrocytoma / metabolism. Electrophoresis, Gel, Two-Dimensional / methods. Gene Expression Regulation, Neoplastic. Glioma / metabolism. Proteomics / methods

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  • (PMID = 15759318.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Molecular Chaperones; EC 3.4.21.4 / Trypsin
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79. Guo XL, Zhong YF, Sun YH, Liu HH, Jin B, Liang W, Li XS: [Muscle atrophy of hand as an initial sign in a patient with protoplasmic astrocytoma: a case report and literature review]. Beijing Da Xue Xue Bao; 2008 Dec 18;40(6):649-51
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  • [Title] [Muscle atrophy of hand as an initial sign in a patient with protoplasmic astrocytoma: a case report and literature review].
  • We reported a rare case of protoplasmic astrocytoma presenting small muscle atrophy of the right hand as an initial sign.
  • CT and MRI revealed multiply expansive intracranial lesion in left hemisphere, which was highly suspected of cerebral echinococcus or Balo disease.
  • The patient underwent surgical excision and pathological report was protoplasmic astrocytoma, with glial fibrillary acidic protein (GFAP, +++) of immunohistochemical method.
  • We reviewed clinical features, radiological manifestations and pathology of protoplasmic astrocytoma with medical literature documents.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Muscular Atrophy / complications

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  • (PMID = 19088841.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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80. Li HM, Hsu SS, Wang JS, Weng MJ, Fu JH, Chen CK, Lai PH: Cerebral pilocytic astrocytoma with spontaneous intracranial hemorrhage in adults. J Chin Med Assoc; 2008 Nov;71(11):587-93
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  • [Title] Cerebral pilocytic astrocytoma with spontaneous intracranial hemorrhage in adults.
  • Pilocytic astrocytomas are found predominantly in the pediatric population; reports of these tumors are extremely rare in adults.
  • We report 2 cases of adult pilocytic astrocytoma with intracranial hemorrhage.
  • After surgical resection, microscopic examination of the lesions showed pilocytic astrocytomas.
  • Since pilocytic astrocytoma and other cystic tumors with mural nodule (such as hemangioblastoma) have similar findings on conventional CT and MRI, PWI is helpful in the differential diagnosis.
  • The literature on hemorrhagic pilocytic astrocytoma is also reviewed.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Cerebral Hemorrhage / etiology

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  • (PMID = 19015059.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
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81. Nguyen C, Borruat FX: Bilateral peripapillary subretinal neovessel membrane associated with chronic papilledema: report of two cases. Klin Monbl Augenheilkd; 2005 Mar;222(3):275-8
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  • BACKGROUND: Increased intracranial pressure (ICP) usually results in headaches and papilledema with infrequent loss of visual acuity.
  • Cerebral imaging revealed a pilocytic astrocytoma and hydrocephaly.
  • Severe papilledema and PSNVM were present in both eyes due to idiopathic intracranial hypertension.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Hydrocephalus / complications. Intracranial Hypertension / complications. Optic Disk / blood supply. Papilledema / complications. Retinal Neovascularization / complications. Vision Disorders / etiology


82. Koga N, Ishikawa H: [Clinical evaluation of primary position upbeat nystagmus]. Nippon Ganka Gakkai Zasshi; 2005 Apr;109(4):205-9
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  • In 7 out of 11 patients, intracranial lesions were identified by computed tomography and magnetic resonance imaging.
  • They were located in the median portion of the cerebellum and medulla oblongata except for one adult patient with astrocytoma.
  • The etiologies were 4 tumors, 3 intracranial vascular disorders, 2 Wernicke encephalopathies, 1 congenital anomaly, and 1 inflammation.
  • [MeSH-minor] Adult. Aged. Astrocytoma / complications. Brain Neoplasms / complications. Cerebellum / pathology. Cerebrovascular Disorders / complications. Child. Child, Preschool. Female. Humans. Male. Medulla Oblongata / pathology. Middle Aged

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  • (PMID = 15859150.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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83. Pascual-Castroviejo I, Pascual-Pascual SI, Velázquez-Fragua R, Viaño J, Carceller F, Hernández-Moneo JL, Gutiérrez-Molina M, Morales C: [Subependymal giant cell astrocytoma in tuberous sclerosis complex. A presentation of eight paediatric patients]. Neurologia; 2010 Jun;25(5):314-21
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  • [Title] [Subependymal giant cell astrocytoma in tuberous sclerosis complex. A presentation of eight paediatric patients].
  • [Transliterated title] Astrocitoma subependimario de células gigantes en el complejo de esclerosis tuberosa. Presentación de ocho pacientes infantiles.
  • OBJECTIVE: Presentation of 8 patients with subependymal giant-cell astrocytomas (SGCA) associated with tuberous sclerosis complex (TSC).
  • Three of the patients were admitted urgently due to blindness and increased intracranial pressure.
  • [MeSH-major] Astrocytoma / etiology. Astrocytoma / pathology. Brain Neoplasms / etiology. Brain Neoplasms / pathology. Tuberous Sclerosis


84. Hicdonmez T, Kilincer C, Hamamcioglu MK, Cobanoglu S: Paraplegia due to spinal subdural hematoma as a complication of posterior fossa surgery: Case report and review of the literature. Clin Neurol Neurosurg; 2006 Sep;108(6):590-4
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  • Although blood contamination of cerebrospinal fluid (CSF) after an intracranial operation is possible, development of a symptomatic spinal hematoma after a posterior fossa surgery has never been reported.
  • [MeSH-major] Astrocytoma / surgery. Hematoma, Subdural, Spinal / etiology. Infratentorial Neoplasms / surgery. Paraplegia / etiology. Postoperative Complications

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  • (PMID = 15890442.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 15
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85. Parlato C, Barbarisi M, Moraci M, Moraci A: Surgery, radiotherapy and temozolomide in treating high-grade gliomas. Front Biosci; 2006;11:1280-3
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  • Twelve patients with newly diagnosed glioblastoma (GBM), and anaplastic astrocytoma (AA) were studied.
  • Surgery allows to establish a histopathological diagnosis, to improve signs and symptoms which are attributable to intracranial hypertension or tumour topography, and to reduce the number of target cells for adjunctive therapies.
  • [MeSH-minor] Adult. Astrocytoma / therapy. Clinical Trials as Topic. Disease Progression. Disease-Free Survival. Female. Glioblastoma / therapy. Humans. Male. Middle Aged. Quality of Life. Radiotherapy. Time Factors. Treatment Outcome

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  • (PMID = 16368514.001).
  • [ISSN] 1093-9946
  • [Journal-full-title] Frontiers in bioscience : a journal and virtual library
  • [ISO-abbreviation] Front. Biosci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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86. Gupta B, Torchilin VP: Monoclonal antibody 2C5-modified doxorubicin-loaded liposomes with significantly enhanced therapeutic activity against intracranial human brain U-87 MG tumor xenografts in nude mice. Cancer Immunol Immunother; 2007 Aug;56(8):1215-23
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  • [Title] Monoclonal antibody 2C5-modified doxorubicin-loaded liposomes with significantly enhanced therapeutic activity against intracranial human brain U-87 MG tumor xenografts in nude mice.
  • Here, we investigate the therapeutic efficacy of monoclonal anticancer antibody 2C5-modified long-circulating liposomes (LCL) loaded with doxorubicin (2C5-DoxLCL) for the treatment of U-87 MG human brain tumors in an intracranial model in nude mice.
  • The treatment of intracranial U-87 MG brain tumors in nude mice with 2C5-DoxLCL provides a significant therapeutic benefit over control formulations, substantially reducing the tumor size and almost doubling the survival time.
  • Thus, monoclonal antibody 2C5-modified LCL can specifically target the anticancer drugs to brain tumors, leading to improved therapeutic treatment of brain tumor in an intracranial model, in vivo.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Astrocytoma / drug therapy. Brain Neoplasms / drug therapy. Doxorubicin / therapeutic use. Immunoconjugates / therapeutic use

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  • (PMID = 17219149.001).
  • [ISSN] 0340-7004
  • [Journal-full-title] Cancer immunology, immunotherapy : CII
  • [ISO-abbreviation] Cancer Immunol. Immunother.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL55519
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Immunoconjugates; 0 / Liposomes; 0 / Nucleosomes; 30IQX730WE / Polyethylene Glycols; 80168379AG / Doxorubicin
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87. Morris BS, Nagar AM, Morani AC, Chaudhary RK, Garg PA, Chudgar PD, Raut AA: Blood-fluid levels in the brain. Br J Radiol; 2007 Jun;80(954):488-98
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  • 17 cases reviewed prospectively over a period of 4 months highlight the varied appearance of blood-fluid levels in intracranial cystic lesions of different aetiologies; a finding which has not featured significantly in the medical literature.
  • Four types of intracranial cysts demonstrating blood-fluid levels have been categorised according to the nature of the pathology, i.e. primary neoplasms of the brain, metastatic deposits to the brain in cases of extraneural malignancies, lesions of vascular aetiology and intraparenchymal bleeds secondary to trauma.
  • The group of four primary intracranial neoplasms lists an oligodendroglioma, a recurrent tumour in a case of Von Hippel-Lindau syndrome, a Grade 3 astrocytoma and an acoustic schwannoma.
  • Intracranial cysts within tumours have been postulated to occur secondary to a breakdown of the blood-brain barrier (BBB) rather than as a result of tumoural degeneration, as was thought probable earlier.

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  • (PMID = 17684079.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 20
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88. Maes L, Van Neste L, Van Damme K, Kalala JP, De Ridder L, Bekaert S, Cornelissen M: Relation between telomerase activity, hTERT and telomere length for intracranial tumours. Oncol Rep; 2007 Dec;18(6):1571-6
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  • [Title] Relation between telomerase activity, hTERT and telomere length for intracranial tumours.
  • For gliomas, no active telomerase was detected in 2 low-grade astrocytomas, whereas three of the four screened glioblastomas were positive for telomerase activity.
  • The only hTERT protein positive astrocytoma had a mean labelling index of 9.0%.
  • The two low-grade astrocytomas had a telomere length of 14.310 and 9.236 kb.
  • The anaplastic astrocytoma had a telomere length of 4.903 kb and the glioblastomas 5.767 kb (SD=2.042).
  • [MeSH-minor] Astrocytoma / enzymology. Astrocytoma / genetics. Astrocytoma / pathology. Biopsy. Glioblastoma / enzymology. Glioblastoma / genetics. Glioblastoma / pathology. Humans

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  • (PMID = 17982646.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.7.49 / Telomerase
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89. Jha B, Kothari M: Pearls & oy-sters: hyperdense or pseudohyperdense MCA sign: a Damocles sword? Neurology; 2009 Jun 9;72(23):e116-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Astrocytoma / radiography. Brain / radiography. Brain Neoplasms / radiography. Diagnostic Errors / prevention & control. Hypoxia-Ischemia, Brain / radiography. Infarction, Middle Cerebral Artery / radiography
  • [MeSH-minor] Biomarkers / analysis. Calcinosis / pathology. Calcinosis / physiopathology. Calcinosis / radiography. Diagnosis, Differential. Disease Progression. Humans. Intracranial Thrombosis / pathology. Intracranial Thrombosis / physiopathology. Intracranial Thrombosis / radiography. Magnetic Resonance Angiography / methods. Male. Middle Aged. Middle Cerebral Artery / pathology. Middle Cerebral Artery / physiopathology. Middle Cerebral Artery / radiography. Predictive Value of Tests. Tomography, X-Ray Computed / methods

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  • (PMID = 19506216.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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90. Debono B, Derrey S, Rabehenoina C, Proust F, Freger P, Laquerrière A: Primary diffuse multinodular leptomeningeal gliomatosis: case report and review of the literature. Surg Neurol; 2006 Mar;65(3):273-82; discussion 282
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  • Histological examination revealed an anaplastic astrocytoma.
  • [MeSH-major] Astrocytoma / surgery. Meningeal Neoplasms / surgery. Neoplasms, Neuroepithelial / surgery. Peripheral Nervous System Neoplasms / surgery. Spinal Nerve Roots / surgery
  • [MeSH-minor] Brain / pathology. Cerebellum / pathology. Diagnosis, Differential. Fatal Outcome. Humans. Intracranial Pressure / physiology. Male. Meninges / pathology. Middle Aged. Neoplasm Invasiveness / pathology. Neurologic Examination. Prognosis

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  • (PMID = 16488248.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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91. Boss A, Bisdas S, Kolb A, Hofmann M, Ernemann U, Claussen CD, Pfannenberg C, Pichler BJ, Reimold M, Stegger L: Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT. J Nucl Med; 2010 Aug;51(8):1198-205
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  • [Title] Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT.
  • In a pilot study of 10 patients with intracranial masses, the feasibility of tumor assessment using a PET/MRI system comprising lutetium oxyorthosilicate scintillators coupled to avalanche photodiodes was evaluated, and quantification accuracy was compared with conventional PET/CT datasets.
  • Diagnoses at the time of referral were low-grade astrocytoma (n = 2), suspicion of low-grade astrocytoma (n = 1), anaplastic astrocytoma (World Health Organization grade III; n = 1), glioblastoma (n = 2), atypical neurocytoma (n = 1), and meningioma (n = 3).

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  • (PMID = 20660388.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gallium Radioisotopes; 0 / Radiopharmaceuticals; AE28F7PNPL / Methionine; RWM8CCW8GP / Octreotide; U194AS08HZ / Edotreotide
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92. French PJ, Barlow A, Barlow P, Jampana RV, Stewart W: A case of pilomyxoid astrocytoma presenting with CSF rhinorrhoea in a 15-year-old. Br J Neurosurg; 2009;23(5):545-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pilomyxoid astrocytoma presenting with CSF rhinorrhoea in a 15-year-old.
  • We report a pilomyxoid astrocytoma (PMA) presenting with CSF rhinorrhoea in a 15-year-old.
  • This uncommon, recently described entity typically presents in infancy with focal neurological or endocrine symptoms, has distinctive histologic features and displays a more aggressive behaviour than pilocytic astrocytoma (PA) with which it was previously classified.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Cerebrospinal Fluid Rhinorrhea / etiology
  • [MeSH-minor] Adolescent. Humans. Intracranial Hypertension / etiology. Male

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  • (PMID = 19718549.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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93. Menkü A, Oktem IS, Kontaş O, Akdemir H: Atypical intracerebral schwannoma mimicking glial tumor: case report. Turk Neurosurg; 2009 Jan;19(1):82-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The initial diagnosis being considered was primary intracranial tumor, including high-grade astrocytoma, metastasis or lymphoma Histopathological examination revealed schwannoma.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Epilepsy / pathology. Magnetic Resonance Imaging. Neurilemmoma / pathology


94. Eskandary H, Sabba M, Khajehpour F, Eskandari M: Incidental findings in brain computed tomography scans of 3000 head trauma patients. Surg Neurol; 2005 Jun;63(6):550-3; discussion 553
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Limited reports exist about intracranial incidental findings on computed tomography (CT) imaging.
  • RESULTS: In this study we found 30 incidental abnormalities that include 8 cases of tumor: 3 meningioma, 2 craniopharyngioma, 1 oligodendroglioma, 1 low-grade astrocytoma, and 1 medulloblastoma.


95. Ng WH, Lim T, Yeo TT: Pleomorphic xanthoastrocytoma in elderly patients may portend a poor prognosis. J Clin Neurosci; 2008 Apr;15(4):476-8
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  • Rarely, in older patients, PXA may have a poor prognosis as these patients tend to have intracranial hypertension and focal deficits, as well as histological features of mitosis, increased cellularity and necrosis.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis

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  • (PMID = 18255294.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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96. Tong Z, Wanibuchi M, Uede T, Tanabe S, Hashi K: Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report. Neurosurgery; 2006 Apr;58(4):E792; discussion E792
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  • [Title] Significant improvement of visual functions after removal of an intracranial giant optic nerve glioma revealing exophytic growth: case report.
  • OBJECTIVE AND IMPORTANCE: Intracranial giant optic nerve gliomas, usually presumed as optic chiasmatic gliomas, are much less common.
  • Surgical decompression for intracranial optic gliomas frequently leads to clinical improvement, but obvious improvement of vision is rare.
  • We report a case that demonstrated significant recovery of visual function after removal of the intracranial giant optic nerve glioma, revealing exophytic growth.
  • On heavily T2-reversed MRIs, it was obvious that the intracranial portion of right optic nerve was enlarged, and optic tracts were shifted to the left by the tumor.
  • The histological diagnosis was pilocytic astrocytoma.
  • CONCLUSION: Giant exophytic gliomas without neurofibromatosis type 1 may arise from the intracranial portion of an isolated optic nerve.
  • Direct visualization of optic component by heavily T2-reversed MRI could more precisely delineate the relationship of the intracranial optic nerve glioma to the optic apparatus.
  • Surgery may be indicated in giant exophytic intracranial optic nerve gliomas and preoperative postulated optic chiasmatic gliomas.

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  • (PMID = 16575300.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Madhankumar AB, Slagle-Webb B, Wang X, Yang QX, Antonetti DA, Miller PA, Sheehan JM, Connor JR: Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model. Mol Cancer Ther; 2009 Mar;8(3):648-54
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  • [Title] Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model.
  • Based on this observation, we developed an intracranial brain tumor model in nude mice using human U87 glioma cells.
  • Mice receiving weekly i.p. injections of 15 mg/kg of doxorubicin encapsulated in IL-13-conjugated liposomes had a 5-fold reduction in the intracranial tumor volume over 6 weeks and four of seven animals survived >200 days after tumor implantation.
  • Finally, a model of the blood-brain barrier was used to show that the nanovesicles do not harm the endothelial cells yet maintain their toxicity to astrocytoma cells.
  • [MeSH-major] Astrocytoma / drug therapy. Brain Neoplasms / drug therapy. Doxorubicin / administration & dosage. Receptors, Interleukin-13 / antagonists & inhibitors

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  • (PMID = 19276162.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Liposomes; 0 / Receptors, Interleukin-13; 80168379AG / Doxorubicin
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98. Ho BL, Lieu AS, Hsu CY: Hemiparkinsonism secondary to an infiltrative astrocytoma. Neurologist; 2008 Jul;14(4):258-61
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  • [Title] Hemiparkinsonism secondary to an infiltrative astrocytoma.
  • Brain computed tomography failed to reveal an intracranial lesion.
  • Histopathologic findings confirmed the diagnosis of high-grade astrocytoma.
  • [MeSH-major] Astrocytoma / complications. Astrocytoma / pathology. Brain Neoplasms / complications. Brain Neoplasms / pathology. Parkinsonian Disorders / etiology

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  • (PMID = 18617854.001).
  • [ISSN] 1074-7931
  • [Journal-full-title] The neurologist
  • [ISO-abbreviation] Neurologist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Murai N, Kaneko T: [Case of jugular foramen schwannoma associated with tuberous sclerosis]. No Shinkei Geka; 2007 Oct;35(10):1007-11
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  • Her tuberous sclerosis was diagnosed at the age of 9, when she developed hydrocephalus caused by subependymal giant cell astrocytoma near the foramen of Monro, which was treated by surgical resection and VP shunt placement followed by radiation and chemotherapy.
  • Intracranial schwannoma complicating tuberous sclerosis is very rare.
  • [MeSH-minor] Adult. Astrocytoma / etiology. Astrocytoma / therapy. Cerebral Ventricle Neoplasms / etiology. Cerebral Ventricle Neoplasms / therapy. Cerebral Ventricles. Female. Humans. Hydrocephalus / etiology. Treatment Outcome

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  • (PMID = 17969337.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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100. Hocwald O, McFadden D, Osiovich H, Dunham C: Congenital gliosarcoma: detailed clinicopathologic documentation of a rare neoplasm. Pediatr Dev Pathol; 2009 Sep-Oct;12(5):398-403
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  • Teratomas and astrocytomas appear to be the most common congenital neoplasms.
  • Amongst the latter, all grades and many subtypes are represented in the congenital time period, including the diffusely infiltrative forms of astrocytoma.
  • Gliosarcoma is currently considered a variant of glioblastoma (i.e., astrocytoma, World Health Organization grade IV) that exhibits genetically similar yet phenotypically separate histologic regions of high-grade astrocytoma and sarcoma.
  • We detail the case of a 1-day-old term male who presented with macrocrania, hydrocephalus, and signs of increased intracranial pressure.

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  • (PMID = 19883237.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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