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Items 1 to 100 of about 168
1. Pareés I, Alonso J, Rovira A, Martínez E, Montalban X: [Diffuse astrocytoma presenting as an optic-spinal syndrome]. Rev Neurol; 2009 Apr 1-15;48(7):354-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diffuse astrocytoma presenting as an optic-spinal syndrome].
  • [Transliterated title] Síndrome opticomedular como forma de presentación de un astrocitoma difuso.
  • INTRODUCTION: Spinal cord involvement is a rare presentation of grade II astrocytomas.
  • A patient with an optic-spinal syndrome due to a fibrillary astrocytoma is described.
  • A new MRI with spectroscopy revealed an infiltrative lesion involving the right frontal lobe, optic chiasm, internal capsule, brainstem and cervical spinal cord, which was suggestive of low-grade astrocytoma.
  • Brain biopsy confirmed the diagnosis of diffuse fibrillary astrocytoma.
  • [MeSH-major] Astrocytoma. Demyelinating Diseases. Optic Neuritis. Spinal Cord / pathology

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  • (PMID = 19319816.001).
  • [ISSN] 1576-6578
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Oligoclonal Bands
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2. D'Angelo A, Capucchio MT, Ferroglio E, Jaggy A: Astrocytoma in a chamois. Schweiz Arch Tierheilkd; 2005 Oct;147(10):453-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Astrocytoma in a chamois.
  • Astrocytomas represent the most common cerebral tumors in humans and in animals, and the fibrillary cytological subtype is the most frequently observed.
  • In this report and for the first time, a thalamic astrocytoma is described in a chamois showing depressed mentation, pleurothotonus and circling to the right side.
  • [MeSH-major] Astrocytoma / veterinary. Brain Neoplasms / veterinary. Goat Diseases / diagnosis. Rupicapra

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  • (PMID = 16259411.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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3. Inoue T, Ogasawara K, Kumabe T, Jokura H, Watanabe M, Ogawa A: Minute glioma identified by 3.0 Tesla magnetic resonance spectroscopy--case report. Neurol Med Chir (Tokyo); 2005 Feb;45(2):108-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The histological diagnosis was fibrillary astrocytoma.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Magnetic Resonance Spectroscopy

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  • (PMID = 15722611.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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4. Skardelly M, Armbruster FP, Meixensberger J, Hilbig H: Expression of Zonulin, c-kit, and Glial Fibrillary Acidic Protein in Human Gliomas. Transl Oncol; 2009 Aug 18;2(3):117-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Zonulin, c-kit, and Glial Fibrillary Acidic Protein in Human Gliomas.
  • We selected for histological examination five cases of glioblastoma WHO IV (nomenclature of the World Health Organization) and one case each from astrocytoma WHO III, meningioma WHO III, and meningioma WHO I as control samples.
  • The visualization of a newly designed antibody against human zonulin was studied in triple-labeling studies using fluorescence immunocytochemistry and compared with the expression of c-kit and glial fibrillary acidic protein in differently developed human gliomas.

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  • (PMID = 19701495.001).
  • [ISSN] 1936-5233
  • [Journal-full-title] Translational oncology
  • [ISO-abbreviation] Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2730142
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5. López JI, Scheithauer BW, Giannini C, Torp SH: Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum. Clin Neuropathol; 2010 Sep-Oct;29(5):301-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum.
  • OBJECTIVE: We report the clinicopathologic features of a solitary fibrous tumor (SFT) having undergone malignant transformation and being intimately associated with a WHO Grade II astrocytoma.
  • CONCLUSION: The biologic basis for the association of SFT and astrocytoma is unknown.
  • Lastly, induction of the glioma by the solitary fibrous tumor, a mechanism invoked to explain the poorly understood "sarcoglioma," deserves consideration.
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / epidemiology. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / epidemiology. Solitary Fibrous Tumors / diagnosis. Solitary Fibrous Tumors / epidemiology

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  • (PMID = 20860893.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Xu Y, Li WL, Fu L, Gu F, Ma YJ: Slit2/Robo1 signaling in glioma migration and invasion. Neurosci Bull; 2010 Dec;26(6):474-8
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  • The expression of Slit2 is at very low levels in pilocytic astrocytoma, fibrillary astrocytoma and glioblastoma, while Robo1 is highly expressed in different grades of gliomas at both mRNA and protein levels.

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  • (PMID = 21113198.001).
  • [ISSN] 1995-8218
  • [Journal-full-title] Neuroscience bulletin
  • [ISO-abbreviation] Neurosci Bull
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Nerve Tissue Proteins; 0 / Receptors, Immunologic; 0 / Slit homolog 2 protein; 0 / roundabout protein; EC 3.6.5.2 / cdc42 GTP-Binding Protein
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7. Zhang S, Wang X, Zhang Z, Chen Y: Tanycytic ependymoma arising from the right lateral ventricle: a case report and review of the literature. Neuropathology; 2008 Aug;28(4):427-32
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  • Histologically, the tumor composed of nuclear dense zones consisting of a cluster of spindle cells and fibrillary zones consisting of streaming of cell processes.
  • Histological differential diagnosis includes spindle-shaped neuroepithelial tumors, such as pilocytic astrocytoma, fibrillary astrocytoma and schwannoma.

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  • (PMID = 18312548.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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8. Bayrakli F, Dinçer A, Sav A, Vardareli E, Peker S: Late brain stem radionecrosis seventeen years after fractionated radiotherapy. Turk Neurosurg; 2009 Apr;19(2):182-5
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  • We present a 24-year-old patient who suffered from right-sided hemiparesis and ataxic gait with a history of an operation due to left frontoparieal grade II fibrillary astrocytoma and fractioned radiotherapy.
  • [MeSH-major] Astrocytoma / radiotherapy. Brain Neoplasms / radiotherapy. Brain Stem / pathology. Radiation Injuries / pathology

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  • (PMID = 19431132.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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9. Watanabe T, Katayama Y, Yoshino A, Yachi K, Ohta T, Ogino A, Komine C, Fukushima T: Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression. Brain Pathol; 2007 Jan;17(1):5-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression.
  • The aim of the present study was to elucidate genetic alterations that are critically involved in astrocytoma progression.
  • We characterized 27 World Health Organization grade II fibrillary astrocytomas which later underwent recurrence or progression, paying specific attention to the CpG island methylation status of critical growth regulatory genes. p14(ARF) and O(6)-methylguanine-DNA methyltransferase (MGMT) hypermethylation represented frequent events (26% and 63%, respectively), which were mutually exclusive except in one case, with alternate or simultaneous methylation of these two genes occurring in 85% of our tumor series.
  • Our findings suggest that p14(ARF) hypermethylation and MGMT hypermethylation constitute distinct molecular pathways of astrocytoma progression, which could differ in biological behavior and clinical outcome.
  • [MeSH-major] Astrocytoma / metabolism. Brain Neoplasms / metabolism. CpG Islands / physiology. Neoplasm Recurrence, Local / metabolism. O(6)-Methylguanine-DNA Methyltransferase / metabolism. Tumor Suppressor Protein p14ARF / metabolism

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  • (PMID = 17493032.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Protein p53; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
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10. Habek M, Brinar VV, Mubrin Z, Barun B, Zarković K: Bilateral thalamic astrocytoma. J Neurooncol; 2007 Sep;84(2):175-7
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  • [Title] Bilateral thalamic astrocytoma.
  • Brain MRI revealed tumor mass in both thalami and according to WHO classification, the tumor corresponded to diffuse fibrillary astrocytoma grade II.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Thalamus / pathology

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  • (PMID = 17522784.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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11. Mei H, Xing Y, Yang A, Wang J, Xu Y, Wang Z, Heiligenhaus A: Astrocytoma of the ciliary body. Ophthalmologica; 2009;223(1):72-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Astrocytoma of the ciliary body.
  • PURPOSE: To report the occurrence of an astrocytoma of the ciliary body.
  • Histopathology revealed a fibrillary astrocytoma.
  • Staining for glial fibrillary acidic protein yielded positive results and neuron-specific enolase yielded negative results.
  • CONCLUSIONS: We describe an astrocytoma of the ciliary body in a patient, which is an extremely rare ocular tumor.
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / surgery. Ciliary Body. Uveal Neoplasms / diagnosis. Uveal Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry / methods. Microscopy, Acoustic. Phosphopyruvate Hydratase / analysis. Staining and Labeling. Ultrasonography, Doppler, Color

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 19033704.001).
  • [ISSN] 1423-0267
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; EC 4.2.1.11 / Phosphopyruvate Hydratase
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12. Porter A, Lyons MK, Wingerchuk DM, Bosch EP: Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. Clin Neurol Neurosurg; 2006 Dec;108(8):787-9
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  • [Title] Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension.
  • Open biopsy confirmed a grade 3 fibrillary astrocytoma.
  • The suspected mechanisms of spinal tumors causing increased intracranial pressure are reviewed as well as three other cases of spinal astrocytomas previously reported in the literature that presented with papilledema and increased intracranial pressure without hydrocephalus.
  • [MeSH-major] Astrocytoma / diagnosis. Pseudotumor Cerebri / etiology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 16298472.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Yue WY, Chen ZP: Does vasculogenic mimicry exist in astrocytoma? J Histochem Cytochem; 2005 Aug;53(8):997-1002
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does vasculogenic mimicry exist in astrocytoma?
  • It is unknown whether a similar VM phenomenon exists in astrocytoma.
  • The present study was to examine 45 astrocytomas (including World Health Organization grade II 15 cases, grade III 15 cases, and grade IV 15 cases) by CD34 endothelial marker periodic acid-Schiff (PAS) dual staining to see if VM existing in these tumors.
  • PAS-positive pattern of VM was found in two grade IV astrocytomas.
  • Furthermore, in astrocytoma, especially glioblastoma, focus of anaplastic tumor cells appeared with CD34 expression, whereas some tumor cells lost glial fibrillary acid protein expression.
  • It is assumed that genetically deregulated tumor cells in astrocytoma could lose the astrocyte-specific protein and express inappropriate markers not expected in cells of astrocyte lineage.
  • The present results suggest that VM phenomenon exists in some malignant astrocytoma.
  • [MeSH-major] Astrocytoma / blood supply. Brain Neoplasms / blood supply

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  • (PMID = 15923371.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Coloring Agents; 0 / Schiff Bases; 10450-60-9 / Periodic Acid
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14. Mondal S, Dirks P, Rutka JT: Immunolocalization of fascin, an actin-bundling protein and glial fibrillary acidic protein in human astrocytoma cells. Brain Pathol; 2010 Jan;20(1):190-9
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  • [Title] Immunolocalization of fascin, an actin-bundling protein and glial fibrillary acidic protein in human astrocytoma cells.
  • In this report, we investigate fascin in astrocytomas.
  • We show that fascin is expressed in astrocytes and in a panel of human astrocytoma cell lines.
  • Immunofluorescence analysis demonstrates that fascin and the intermediate filament protein, glial fibrillary acidic protein (GFAP), are both expressed in the perinuclear region and within cytoplasmic processes of astrocytes and astrocytoma cells.
  • [MeSH-major] Astrocytoma / metabolism. Astrocytoma / ultrastructure. Carrier Proteins / metabolism. Glial Fibrillary Acidic Protein / metabolism. Microfilament Proteins / metabolism

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  • (PMID = 19170683.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Cytoskeletal Proteins; 0 / Fluorescent Dyes; 0 / Glial Fibrillary Acidic Protein; 0 / Indoles; 0 / Microfilament Proteins; 146808-54-0 / fascin; 47165-04-8 / DAPI
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15. Shi Y, Morgenstern N: Granular cell astrocytoma. Arch Pathol Lab Med; 2008 Dec;132(12):1946-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell astrocytoma.
  • Granular cell astrocytoma (GCA) is a rare type of malignant brain tumor with distinct morphologic features and aggressive clinical behavior.
  • The tumor cells are usually positive for glial fibrillary acidic protein, S100, CD68, and epithelial membrane antigen.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Granular Cell Tumor / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Astrocytes / metabolism. Astrocytes / pathology. Diagnosis, Differential. Glial Fibrillary Acidic Protein / metabolism. Humans. Middle Aged. S100 Proteins / metabolism

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  • (PMID = 19061297.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
  • [Number-of-references] 22
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16. Zhao YC, Li NY, Zhou XJ, Zhou HB, Ma HH, Zhang RS: [Clinicopathologic study of pilocytic astrocytoma]. Zhonghua Bing Li Xue Za Zhi; 2008 Sep;37(9):609-14
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  • [Title] [Clinicopathologic study of pilocytic astrocytoma].
  • OBJECTIVE: To study clinicopathologic features, treatment and prognosis of pilocytic astrocytoma (PA).
  • The tumor can be mistaken as higher-grade astrocytoma when involving the subarachnoid space, and with cytological atypia, leading to unnecessary radiotherapy after surgery.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Glial Fibrillary Acidic Protein / genetics. Recurrence

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  • (PMID = 19094585.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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17. Burel-Vandenbos F, Jouvet A, Chanalet S, Lonjon M, Cardot-Leccia N, Michiels JF: [An unusual and misleading form of pilocytic astrocytoma]. Ann Pathol; 2006 Apr;26(2):126-8
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  • [Title] [An unusual and misleading form of pilocytic astrocytoma].
  • [Transliterated title] Une forme rare et trompeuse d'astrocytome pilocytique.
  • Pilocytic astrocytoma is histologically characterized by a biphasic pattern.
  • We report a myxoid form of frontocallosal pilocytic astrocytoma in a 13-year-old girl.
  • Histological examination showed a monophasic tumor composed of piloid cells on a myxoid background corresponding to a pilomyxoid astrocytoma.
  • This unusual form of pilocytic astrocytoma can be mistaken for a high grade infiltrating glioma.
  • Pilomyxoid astrocytoma is more aggressive than classic pilocytic astrocytoma and has to be distinguished from it.
  • [MeSH-major] Astrocytoma / pathology
  • [MeSH-minor] Adolescent. Biomarkers. Diagnosis, Differential. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Magnetic Resonance Imaging. Treatment Outcome

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  • (PMID = 16791125.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Glial Fibrillary Acidic Protein
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18. Kam AY, Tse TT, Kwan DH, Wong YH: Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1alpha in human U87 astrocytoma cells. Cell Signal; 2007 Oct;19(10):2106-17
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  • [Title] Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1alpha in human U87 astrocytoma cells.
  • By using human U87 astrocytoma and transfected FPRL1/CHO cells, we have demonstrated that activation of FPRL1 with WKYMVM effectively phosphorylated JNK and ERK.
  • Importantly, WKYMVM-stimulated U87 cells triggered noticeable increases in glial fibrillary acidic protein (GFAP) and interleukin-1alpha (IL-1alpha), which are correlated with reactive astrocytosis.
  • [MeSH-major] Astrocytes / metabolism. Glial Fibrillary Acidic Protein / biosynthesis. Interleukin-1alpha / biosynthesis. MAP Kinase Signaling System. Mitogen-Activated Protein Kinases / metabolism. Receptors, Formyl Peptide / metabolism. Receptors, Lipoxin / metabolism
  • [MeSH-minor] Amyloid beta-Peptides / toxicity. Animals. Astrocytoma. CHO Cells. Cell Death. Cell Line, Tumor. Cricetinae. Cricetulus. Enzyme Inhibitors / pharmacology. GTP-Binding Protein alpha Subunits, Gi-Go / metabolism. Humans. Oligopeptides / pharmacology. Peptide Fragments / toxicity. Up-Regulation. src-Family Kinases / metabolism

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  • (PMID = 17643960.001).
  • [ISSN] 0898-6568
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Amyloid beta-Peptides; 0 / Enzyme Inhibitors; 0 / FPR2 protein, human; 0 / Glial Fibrillary Acidic Protein; 0 / Interleukin-1alpha; 0 / Oligopeptides; 0 / Peptide Fragments; 0 / Receptors, Formyl Peptide; 0 / Receptors, Lipoxin; 0 / Trp-Lys-Tyr-Met-Val-Met; 0 / amyloid beta-protein (1-42); EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gi-Go
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19. Wei LC, Shi M, Cao R, Chen LW, Chan YS: Nestin small interfering RNA (siRNA) reduces cell growth in cultured astrocytoma cells. Brain Res; 2008 Feb 27;1196:103-12
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  • [Title] Nestin small interfering RNA (siRNA) reduces cell growth in cultured astrocytoma cells.
  • In the present study, we have investigated the possible role of nestin expression in cell growth or survival of CNS tumor cells by using novel small interfering RNA (siRNA) method in cell culture of rat astrocytoma C6 cell line.
  • The nestin expression and cell growth of the cultured astrocytoma cells were examined after nestin siRNA duplex was delivered by cell transfection for 6 h and cell culture was maintained for 48 h.
  • It revealed an effective suppression influence of nestin siRNA on cell growth of cultured astrocytoma cells in a dose-dependent manner.
  • The nestin siRNA also suppressed expression of cellular glial fibrillary acid protein but showed no obvious influence on expression level of Ki-67 protein (a cell proliferation marker).
  • This study has provided in vitro evidence that nestin siRNA can effectively block nestin expression and reduce cell growth of the cultured C6 astrocytoma cells, strongly suggesting that nestin siRNA-induced suppression of tumor cell growth may provide a potential novel clinical therapy against CNS astroglioma events.
  • [MeSH-major] Astrocytoma / metabolism. Astrocytoma / physiopathology. Intermediate Filament Proteins / genetics. Nerve Tissue Proteins / genetics. RNA, Small Interfering / metabolism
  • [MeSH-minor] Analysis of Variance. Animals. Cell Count. Cell Line, Tumor. Dose-Response Relationship, Drug. Gene Expression Regulation / drug effects. Glial Fibrillary Acidic Protein / metabolism. Nestin. Rats

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  • (PMID = 18234160.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, rat; 0 / Nestin; 0 / RNA, Small Interfering
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20. Chen L, Wang Y, Zhu XZ: [Pilomyxoid astrocytoma: a clinicopathologic study of three cases]. Zhonghua Bing Li Xue Za Zhi; 2006 Dec;35(12):727-30

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  • [Title] [Pilomyxoid astrocytoma: a clinicopathologic study of three cases].
  • OBJECTIVE: To study the clinicopathologic features of pilomyxoid astrocytoma (PmA).
  • Immunohistochemical study for glial fibrillary acidic protein (GFAP), CD34 and Ki-67 was performed on paraffin-embedded sections by standard EnVision method.
  • The biphasic pattern noted in a classic pilocytic astrocytoma was not found in PmA.
  • CONCLUSIONS: PmA is a distinctive variant of pilocytic astrocytoma with subtle histologic differences.
  • Compared with conventional pilocytic astrocytoma, PmA behaves more aggressively.
  • [MeSH-major] Astrocytoma / pathology. Cerebral Ventricle Neoplasms / pathology. Optic Nerve Glioma / pathology. Third Ventricle / pathology
  • [MeSH-minor] Antigens, CD34 / metabolism. Child. Diagnosis, Differential. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Infant. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 17374256.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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21. Chen JH, Wu KY, Chiu IM, Tsou TC, Chou CC: Acrylamide-induced astrogliotic and apoptotic responses in human astrocytoma cells. Toxicol In Vitro; 2009 Aug;23(5):855-61
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  • [Title] Acrylamide-induced astrogliotic and apoptotic responses in human astrocytoma cells.
  • The increase of glial fibrillary acidic protein (GFAP) as a chemical-induced astrogliotic response was found to be associated with different ACR concentrations and exposure times, particularly at >or=48h of >or=2mM.
  • These results suggest that ACR exposure may lead to apoptotic and astrogliotic effects in human astrocytoma cells in vitro in a time- and dose-dependent manner.
  • [MeSH-minor] Astrocytoma / pathology. Cell Line, Tumor. Cell Survival / drug effects. Dose-Response Relationship, Drug. Glial Fibrillary Acidic Protein / drug effects. Humans. L-Lactate Dehydrogenase / metabolism. Phosphorylation / drug effects. Time Factors. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19426797.001).
  • [ISSN] 1879-3177
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Tumor Suppressor Protein p53; 20R035KLCI / Acrylamide; EC 1.1.1.27 / L-Lactate Dehydrogenase
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22. Tanaka Y, Sasaki A, Ishiuchi S, Nakazato Y: Diversity of glial cell components in pilocytic astrocytoma. Neuropathology; 2008 Aug;28(4):399-407
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  • [Title] Diversity of glial cell components in pilocytic astrocytoma.
  • To characterize the cellular density and proliferative activity of GFAP-negative cells in pilocytic astrocytoma (PA), surgically excised tissues of PAs (n=37) and diffuse astrocytomas (DAs) (n=11) were examined morphologically and immunohistochemically using antibodies against GFAP, Olig2, Iba1 and Ki-67 (MIB-1).
  • [MeSH-major] Astrocytoma / metabolism. Basic Helix-Loop-Helix Transcription Factors / biosynthesis. Biomarkers, Tumor / analysis. Brain Neoplasms / metabolism. Nerve Tissue Proteins / biosynthesis. Neuroglia / metabolism
  • [MeSH-minor] Adult. Aged. Child. Child, Preschool. DNA-Binding Proteins / biosynthesis. Diagnosis, Differential. Female. Glial Fibrillary Acidic Protein / biosynthesis. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Infant, Newborn. Ki-67 Antigen / biosynthesis. Male. Middle Aged

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  • (PMID = 18312545.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / AIF1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Nerve Tissue Proteins; 0 / OLIG2 protein, human
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23. Temel SG, Kahveci Z: Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. J Mol Histol; 2009 Oct;40(5-6):369-77
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  • [Title] Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma.
  • For this purpose we employed dual immunohistochemistry for cox-2 and GFAP (astrocyte) or LCA-MAC (microglia-macrophage) in archival formalin-fixed, paraffin embedded human tissue diagnosed as oligodendroglioma and/or astrocytoma.
  • [MeSH-major] Astrocytes / enzymology. Astrocytoma / enzymology. Cyclooxygenase 2 / metabolism. Microglia / enzymology. Oligodendroglioma / enzymology
  • [MeSH-minor] Antigens, CD45 / metabolism. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Staining and Labeling

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  • (PMID = 20052522.001).
  • [ISSN] 1567-2387
  • [Journal-full-title] Journal of molecular histology
  • [ISO-abbreviation] J. Mol. Histol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 3.1.3.48 / Antigens, CD45
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24. Reyaz N, Tayyab M, Khan SA, Siddique T: Correlation of glial fibrillary acidic protein (GFAP) with grading of the neuroglial tumours. J Coll Physicians Surg Pak; 2005 Aug;15(8):472-5
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  • [Title] Correlation of glial fibrillary acidic protein (GFAP) with grading of the neuroglial tumours.
  • OBJECTIVE: To determine the distribution of glial fibrillary acidic protein (GFAP) in human neuroglial tumours and its correlation with histologic grading.
  • RESULTS: In positive control only the cell process and perikaryons of fibrous astrocytes was stained.
  • The 35 cases of various grade astrocytoma showed a varying intensity of GFAP staining.
  • Similarly, 3 cases of glioblastoma multiforme, 2 cases of sub-ependymal giant cell astrocytoma, 2 cases of pleomorphic xanthoastrocytoma, 2 out of 4 cases of ependymoma and the case of oligoastrocytoma showed a positive reaction.
  • The stain was more intense over processes than in perikaryons, with the exception of gemistocytic astrocytomas and the giant cells in glioblastoma multiforme, which showed an equally intense stain over perikaryons and processes.
  • GFA protein is specific for glial cells and it is useful to diagnose those glial tumours which are difficult to be identified by heamatoxylin-eosin stain or due to rare or unusual site.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Glial Fibrillary Acidic Protein / metabolism. Glioma / metabolism. Glioma / pathology
  • [MeSH-minor] Astrocytoma / metabolism. Astrocytoma / pathology. Child. Female. Humans. Immunoenzyme Techniques. Immunohistochemistry. Male. Neuroglia / metabolism. Oligodendroglioma / metabolism

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  • (PMID = 16202357.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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25. Rodriguez FJ, Scheithauer BW, Burger PC, Jenkins S, Giannini C: Anaplasia in pilocytic astrocytoma predicts aggressive behavior. Am J Surg Pathol; 2010 Feb;34(2):147-60
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  • [Title] Anaplasia in pilocytic astrocytoma predicts aggressive behavior.
  • The clinical significance of anaplastic features, a rare event in pilocytic astrocytoma (PA), is not fully established.
  • The tumors either had a PA precursor, coexistent (n = 14) (41%) or documented by previous biopsy (n = 10) (29%), or exhibited typical pilocytic features in an otherwise anaplastic astrocytoma (n = 10) (29%).
  • Histologically, the anaplastic component was classified as pilocytic like (41%), small cell (32%), epithelioid (15%), or fibrillary (12%).
  • Overall and progression-free survivals were shorter in the setting of prior radiation for a PA precursor (P = 0.007, 0.028), increasing mitotic activity (P = 0.03, 0.02), and presence of necrosis (P = 0.02, 0.02), after adjusting for age and site.
  • The biologic behavior of PAs with high-mitotic rates and those with necrosis paralleled that of St Anne-Mayo grades 2 and 3 diffuse astrocytomas, respectively.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis

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  • (PMID = 20061938.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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26. de Chadarévian JP, Halligan GE, Reddy G, Bertrand L, Pascasio JM, Faerber EN, Katsetos CD: Glioneuronal phenotype in a diencephalic pilomyxoid astrocytoma. Pediatr Dev Pathol; 2006 Nov-Dec;9(6):480-7
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  • [Title] Glioneuronal phenotype in a diencephalic pilomyxoid astrocytoma.
  • We report the presence of divergent populations of cells in a hypothalamic/chiasmatic pilomyxoid astrocytoma of an 11-month-old male, exhibiting differential immunohistochemical localizations for glial fibrillary acidic protein (GFAP) and synaptophysin.
  • Our results indicate that a subset of the so-called pilomyxoid astrocytomas of the hypothalamic/chiasmatic region may represent phenotypically mixed glioneuronal neoplasms distinct from the pilocytic astrocytomas.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Ganglioglioma / pathology. Hypothalamus / pathology
  • [MeSH-minor] Astrocytes / ultrastructure. Glial Fibrillary Acidic Protein / analysis. Humans. Immunoenzyme Techniques. Infant. Magnetic Resonance Imaging. Male. Microscopy, Confocal. Microscopy, Electron, Transmission. Neurons / ultrastructure. Phenotype. Synaptophysin / analysis

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  • (PMID = 17163791.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Synaptophysin
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27. Nozaki M, Ohnishi A, Fujimaki T, Nagashima K, Cho K, Sawamura Y: Congenital gemistocytic astrocytoma in a fetus. Childs Nerv Syst; 2006 Feb;22(2):168-71
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  • [Title] Congenital gemistocytic astrocytoma in a fetus.
  • This report presents a case of a congenital gemistocytic astrocytoma diagnosed by antenatal intrauterine ultrasound.
  • The histological study revealed gemistocytic astrocytoma (WHO grade II).
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Fetus
  • [MeSH-minor] Adult. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry / methods. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging / methods. Pregnancy. Synaptophysin / metabolism. Tomography, X-Ray Computed / methods

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  • (PMID = 15864706.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Synaptophysin
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28. Yoshida T, Tomozawa Y, Arisato T, Okamoto Y, Hirano H, Nakagawa M: The functional alteration of mutant GFAP depends on the location of the domain: morphological and functional studies using astrocytoma-derived cells. J Hum Genet; 2007;52(4):362-9
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  • [Title] The functional alteration of mutant GFAP depends on the location of the domain: morphological and functional studies using astrocytoma-derived cells.
  • To clarify the functional effects of mutant glial fibrillary acidic protein (GFAP), we examined the expression patterns of mutant GFAPs (V87G, R88C, and R416W) in astrocytoma-derived cells and performed migration assay.
  • [MeSH-major] Alexander Disease / genetics. Gene Expression. Glial Fibrillary Acidic Protein / metabolism
  • [MeSH-minor] Astrocytes / chemistry. Astrocytes / cytology. Astrocytes / metabolism. Astrocytoma. Cell Line, Tumor. Cell Movement / genetics. Humans. Point Mutation. Protein Structure, Tertiary / genetics

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  • (PMID = 17318298.001).
  • [ISSN] 1434-5161
  • [Journal-full-title] Journal of human genetics
  • [ISO-abbreviation] J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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29. Henderson MA, Fakiris AJ, Timmerman RD, Worth RM, Lo SS, Witt TC: Gamma knife stereotactic radiosurgery for low-grade astrocytomas. Stereotact Funct Neurosurg; 2009;87(3):161-7
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  • [Title] Gamma knife stereotactic radiosurgery for low-grade astrocytomas.
  • Patients with low-grade astrocytoma (LGA; 8 pilocytic astrocytomas, 2 subependymal giant cell astrocytomas, 2 fibrillary astrocytomas) were selected for treatment with gamma knife stereotactic radiosurgery (GKSRS) based on having a demarcated appearance on CT or MRI and the possibility of dose sparing of adjacent eloquent structures.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Radiosurgery / methods

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  • [Copyright] 2009 S. Karger AG, Basel.
  • (PMID = 19321969.001).
  • [ISSN] 1423-0372
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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30. Yap L, Crooks D, Warnke P: Low grade astrocytoma of the pituitary stalk. Acta Neurochir (Wien); 2007 Mar;149(3):307-11; discussion 311-2
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  • [Title] Low grade astrocytoma of the pituitary stalk.
  • A case of low grade astrocytoma (WHO grade II) localised in the pituitary stalk is reported in a 46 year old female who presented with central diabetes insipidus.
  • [MeSH-major] Astrocytoma / surgery. Pituitary Neoplasms / surgery
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Humans. Hypophysectomy. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Optic Nerve / pathology. Pituitary Gland / pathology. Pituitary Irradiation. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 17242848.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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31. Saad A, Mo J, Miles L, Witte D: Granular cell astrocytoma of the cerebellum: report of the first case. Am J Clin Pathol; 2006 Oct;126(4):602-7

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  • [Title] Granular cell astrocytoma of the cerebellum: report of the first case.
  • Granular cell astrocytomas are an uncommon morphologic variant of infiltrating gliomas characterized by relatively large tumor cells with granular cytoplasm occupying variable proportions of the tumor.
  • These cells coexpressed glial fibrillary acidic protein and CD68.
  • Of the 49 cases of granular cell astrocytomas reported to date, none have involved the cerebellum.
  • The tumor described herein represents the first case of cerebellar granular cell astrocytoma.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 16938663.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Chen H, Sun XF, Wu JS: [Clinicopathologic study of subependymal giant cell astrocytoma]. Zhonghua Bing Li Xue Za Zhi; 2006 Nov;35(11):656-9
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  • [Title] [Clinicopathologic study of subependymal giant cell astrocytoma].
  • OBJECTIVE: To study the clinicopathologic features of subependymal giant cell astrocytoma.
  • METHODS: The clinical and pathologic characteristics of 18 cases of subependymal giant cell astrocytoma were retrospectively analyzed.
  • The spindle cells showed immunoreactivity for glial fibrillary acidic protein (18/18, 100%), while the gemistocytes and ganglion-like cells expressed synaptophysin (14/18, 77.8%).
  • CONCLUSIONS: Subependymal giant cell astrocytoma is a benign brain tumor with distinctive histopathologic features.
  • [MeSH-major] Astrocytoma / pathology. Cerebral Ventricle Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / biosynthesis. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Synaptophysin / biosynthesis. Tomography, X-Ray Computed. Tuberous Sclerosis / complications. Tuberous Sclerosis / metabolism. Tuberous Sclerosis / pathology. Young Adult

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  • (PMID = 17374208.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Synaptophysin
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33. Dmytrenko VV, Boĭko OI, Shostak KO, Bilets'kyĭ AV, Malysheva TA, Shamaiev MI, Kliuchka VM, Rozumenko VD, Zozulia IuP, Kavsan VM: [Expression of myelin basic protein and glial fibrillary acidic protein genes in human glial brain tumors]. Tsitol Genet; 2009 Jan-Feb;43(1):28-35
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  • [Title] [Expression of myelin basic protein and glial fibrillary acidic protein genes in human glial brain tumors].
  • Analysis of the expression of genes encoding myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) genes in human glial tumors was carried out for determination of the expression specificity of these genes according to tumor types and their malignancy.
  • Low levels of MBP mRNA in astrocytoma specimens of malignancy grades II-IV and significantly higher levels in perifocal zone adjacent to them have been determined by Northern hybridization.
  • Diffuse astrocytomas and anaplastic astrocytomas are characterized mostly by low level of MBP gene expression and high level of GFAP gene expression, but distinct subtypes of diffuse and anaplastic astrocytomas with high level of MBP gene and low level of GFAP gene expression can be also detected that may be the reflection of different oncogenic pathways.
  • [MeSH-major] Biomarkers, Tumor / genetics. Brain Neoplasms / genetics. Gene Expression. Glial Fibrillary Acidic Protein / genetics. Glioma / genetics. Myelin Basic Protein / genetics

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  • (PMID = 19663312.001).
  • [ISSN] 0564-3783
  • [Journal-full-title] T︠S︡itologii︠a︡ i genetika
  • [ISO-abbreviation] Tsitol. Genet.
  • [Language] ukr
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Genetic Markers; 0 / Glial Fibrillary Acidic Protein; 0 / Myelin Basic Protein; 0 / RNA, Messenger
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34. Holden LJ, Coleman MD: Assessment of the astrogliotic responses of three human astrocytoma cell lines to ethanol, trimethyltin chloride and acrylamide. Toxicology; 2007 Nov 20;241(1-2):75-83
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  • [Title] Assessment of the astrogliotic responses of three human astrocytoma cell lines to ethanol, trimethyltin chloride and acrylamide.
  • The astrogliotic responses of the CCF-STTG1, U251-MG, and U373-MG human astrocytoma lines were determined after exposure to ethanol, trimethyltin chloride (TMTC), and acrylamide over 4, 16, and 24h.
  • Basal glial fibrillary acidic protein (GFAP) expression in the U-251MG and U373-MG cells was 10-fold greater than the CCF-STGG1 line.
  • This study underlines the significance of period of exposure, as well as toxin concentration in astrocytoma cellular response to toxic pressure.
  • [MeSH-major] Acrylamide / toxicity. Astrocytoma / pathology. Brain Neoplasms / pathology. Central Nervous System Depressants / toxicity. Ethanol / toxicity. Gliosis / pathology. Trimethyltin Compounds / toxicity
  • [MeSH-minor] Cell Count. Cell Line, Tumor. Enzyme-Linked Immunosorbent Assay. Glial Fibrillary Acidic Protein / biosynthesis. Humans. Mitochondria / drug effects. Mitochondria / enzymology. Oxidoreductases / metabolism. Tetrazolium Salts. Thiazoles

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  • (PMID = 17875352.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Glial Fibrillary Acidic Protein; 0 / Tetrazolium Salts; 0 / Thiazoles; 0 / Trimethyltin Compounds; 20R035KLCI / Acrylamide; 298-93-1 / thiazolyl blue; 3K9958V90M / Ethanol; EC 1.- / Oxidoreductases
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35. McCarthy BJ, Propp JM, Davis FG, Burger PC: Time trends in oligodendroglial and astrocytic tumor incidence. Neuroepidemiology; 2008;30(1):34-44
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  • RESULTS: Using CBTRUS data, the incidences (per 100,000 person-years) of oligodendrogliomas (APC = 4.7), mixed gliomas (APC = 3.9) and anaplastic oligodendrogliomas (APC = 12.5) have all increased over time, while the incidences of astrocytoma not otherwise specified (APC = -8.1) and fibrillary astrocytoma (APC = -2.1) have decreased.
  • [MeSH-major] Astrocytoma / epidemiology. Brain Neoplasms / epidemiology. Glioma / epidemiology. Oligodendroglioma / epidemiology

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18259099.001).
  • [ISSN] 1423-0208
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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36. Stavrinou P, Spiliotopoulos A, Patsalas I, Balogiannis I, Karkavelas G, Polyzoidis K, Selviaridis P: Subependymal giant cell astrocytoma with intratumoral hemorrhage in the absence of tuberous sclerosis. J Clin Neurosci; 2008 Jun;15(6):704-6
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  • [Title] Subependymal giant cell astrocytoma with intratumoral hemorrhage in the absence of tuberous sclerosis.
  • Subependymal giant cell astrocytoma (SEGA) is an uncommon tumor that usually occurs in the setting of tuberous sclerosis (TS) syndrome.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Hemorrhage / etiology
  • [MeSH-minor] Adult. Glial Fibrillary Acidic Protein / metabolism. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 18395450.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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37. Momota H, Narita Y, Matsushita Y, Miyakita Y, Shibui S: p53 abnormality and tumor invasion in patients with malignant astrocytoma. Brain Tumor Pathol; 2010 Oct;27(2):95-101
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  • [Title] p53 abnormality and tumor invasion in patients with malignant astrocytoma.
  • Malignant astrocytomas are characterized by diffusely infiltrating nature, and the abnormality of p53 is a cytogenetic hallmark of astrocytic tumors.
  • To elucidate the relationship between p53 abnormality and invasiveness of the tumors, we studied mutation and protein expression of p53 in 48 consecutive patients with malignant astrocytoma (14 anaplastic astrocytomas and 34 glioblastoma multiformes).
  • As diffuse and multiple features on imaging modalities represent invasive characteristics of the tumors, p53 abnormalities may affect the invasive and aggressive nature of malignant astrocytomas.
  • [MeSH-major] Astrocytoma / genetics. Astrocytoma / pathology. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Genes, p53 / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. DNA, Neoplasm / genetics. Female. Glial Fibrillary Acidic Protein / genetics. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Mitotic Index. Mutation / genetics. Mutation / physiology. Neoplasm Invasiveness / genetics. Neoplasm Invasiveness / pathology. Survival Analysis. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Vascular Endothelial Growth Factor A / metabolism. Young Adult

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  • (PMID = 21046311.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Glial Fibrillary Acidic Protein; 0 / Tumor Suppressor Protein p53; 0 / Vascular Endothelial Growth Factor A
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38. Zhang L, Zhang WP, Hu H, Wang ML, Sheng WW, Yao HT, Ding W, Chen Z, Wei EQ: Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma. Neuropathology; 2006 Apr;26(2):99-106
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  • [Title] Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma.
  • However, there is still no information available for the expression patterns of 5-LOX in human brain following trauma or with astrocytomas.
  • Furthermore, 5-LOX expression increased and showed a granular pattern in high-grade (grade III/IV) astrocytoma.
  • [MeSH-major] Arachidonate 5-Lipoxygenase / biosynthesis. Astrocytoma / metabolism. Brain / metabolism. Brain Injuries / metabolism. Brain Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Neuroglia / metabolism. Neurons / metabolism

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  • (PMID = 16708542.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
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39. Terakawa Y, Morino M, Yamagata T, Ohata K: Extradural pneumatocele after temporal craniotomy: case report. Neurol Med Chir (Tokyo); 2008 Dec;48(12):576-7
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  • A 22-year-old female first presented with a fibrillary astrocytoma in the left temporal region manifesting as complex partial seizure.
  • [MeSH-minor] Arachnoid Cysts / complications. Arachnoid Cysts / surgery. Astrocytoma / complications. Astrocytoma / surgery. Brain Neoplasms / complications. Brain Neoplasms / surgery. Epilepsy, Complex Partial / etiology. Epilepsy, Temporal Lobe / etiology. Female. Humans. Pressure. Temporal Lobe / surgery. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19106498.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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40. Tian R, Gregor M, Wiche G, Goldman JE: Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. Am J Pathol; 2006 Mar;168(3):888-97
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  • [Title] Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease.
  • Alexander disease (AxD) is a rare but fatal neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP).
  • Compared to wild-type GFAP expression, RC GFAP expression lowered plectin levels in astrocytoma-derived stable transfectants and plectin-positive fibroblasts.

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  • (PMID = 16507904.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS042803; United States / NINDS NIH HHS / NS / NS42803
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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41. Zou W, Wang Z, Liu Y, Fan Y, Zhou BY, Yang XF, He JJ: Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes. Glia; 2010 Oct;58(13):1640-8
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  • [Title] Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes.
  • One hallmark of HIV-1 infection of the central nervous system (CNS) is astrocytosis, which is characterized by elevated glial fibrillary acidic protein (GFAP) expression in astrocytes.
  • In this study, we reported concurrent up-regulation of adenovirus E1a-associated 300 kDa protein p300 and GFAP in Tat-expressing human astrocytoma cells and primary astrocytes.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20578042.001).
  • [ISSN] 1098-1136
  • [Journal-full-title] Glia
  • [ISO-abbreviation] Glia
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01NS039804; United States / NIDA NIH HHS / DA / R21 DA029428; United States / NINDS NIH HHS / NS / R01NS065785; United States / NIMH NIH HHS / MH / R01 MH092673; United States / NINDS NIH HHS / NS / R01 NS065785; United States / NINDS NIH HHS / NS / R01 NS039804
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EGR1 protein, human; 0 / Early Growth Response Protein 1; 0 / Glial Fibrillary Acidic Protein; 0 / RNA, Small Interfering; 0 / Tetrazolium Salts; 0 / Thiazoles; 0 / tat Gene Products, Human Immunodeficiency Virus; 10028-17-8 / Tritium; 147336-22-9 / Green Fluorescent Proteins; 298-93-1 / thiazolyl blue; EC 2.3.1.48 / E1A-Associated p300 Protein; EC 2.3.1.48 / EP300 protein, human; EC 3.2.1.23 / beta-Galactosidase; VC2W18DGKR / Thymidine
  • [Other-IDs] NLM/ NIHMS209233; NLM/ PMC2919602
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42. Inagawa H, Ishizawa K, Hirose T: Qualitative and quantitative analysis of cytologic assessment of astrocytoma, oligodendroglioma and oligoastrocytoma. Acta Cytol; 2007 Nov-Dec;51(6):900-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Qualitative and quantitative analysis of cytologic assessment of astrocytoma, oligodendroglioma and oligoastrocytoma.
  • OBJECTIVE: To evaluate the usefulness of intraoperative cytology for differential diagnoses of astrocytoma, oligodendroglioma and oligoastrocytoma.
  • RESULTS: Astrocytomas were characterized by many fibrillary cytoplasmic processes and large, irregular nuclei.
  • Oligoastrocytomas showed combined cytologic profiles of astrocytomas and oligodendrogliomas.
  • Quantitative studies suggested that nuclei of oligodendroglial tumors were significantly rounder than those of astrocytomas.
  • CONCLUSION; Cytologic evaluation using touch or squash preparations is of great help for intraoperative differential diagnosis of astrocytoma, oligodendroglioma and oligoastrocytoma.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Cytodiagnosis / methods. Oligodendroglioma / diagnosis


43. Bachetti T, Di Zanni E, Balbi P, Bocca P, Prigione I, Deiana GA, Rezzani A, Ceccherini I, Sechi G: In vitro treatments with ceftriaxone promote elimination of mutant glial fibrillary acidic protein and transcription down-regulation. Exp Cell Res; 2010 Aug 1;316(13):2152-65
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  • [Title] In vitro treatments with ceftriaxone promote elimination of mutant glial fibrillary acidic protein and transcription down-regulation.
  • Alexander disease is a rare, untreatable and usually fatal neurodegenerative disorder caused by heterozygous mutations of the glial fibrillary acidic protein (GFAP) gene which ultimately lead to formation of aggregates, containing also alphaB-Crystallin, HSP27, ubiquitin and proteasome components.
  • [MeSH-major] Anti-Bacterial Agents / pharmacology. Ceftriaxone / pharmacology. Gene Expression Regulation / drug effects. Glial Fibrillary Acidic Protein / genetics. HSP27 Heat-Shock Proteins / genetics. alpha-Crystallin B Chain / genetics
  • [MeSH-minor] Astrocytoma / drug therapy. Astrocytoma / metabolism. Autophagy. Blotting, Western. Brain Neoplasms / drug therapy. Brain Neoplasms / metabolism. Cell Proliferation. Fluorescent Antibody Technique. Humans. In Vitro Techniques. Luciferases / metabolism. Mutant Proteins / genetics. Mutant Proteins / metabolism. Promoter Regions, Genetic / genetics. Proteasome Endopeptidase Complex / drug effects. Protein Multimerization. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured / drug effects. Tumor Cells, Cultured / metabolism. Ubiquitin / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20471977.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Glial Fibrillary Acidic Protein; 0 / HSP27 Heat-Shock Proteins; 0 / Mutant Proteins; 0 / RNA, Messenger; 0 / Ubiquitin; 0 / alpha-Crystallin B Chain; 75J73V1629 / Ceftriaxone; EC 1.13.12.- / Luciferases; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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44. Choi KC, Kwak SE, Kim JE, Sheen SH, Kang TC: Enhanced glial fibrillary acidic protein-delta expression in human astrocytic tumor. Neurosci Lett; 2009 Oct 9;463(3):182-7
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  • [Title] Enhanced glial fibrillary acidic protein-delta expression in human astrocytic tumor.
  • Therefore, we evaluated glial fibrillary acidic protein (GFAP)-delta, a product of alternative splicing variants of GFAP-alpha, as a diagnostic marker.
  • [MeSH-major] Astrocytoma / metabolism. Biomarkers, Tumor / biosynthesis. Brain Neoplasms / metabolism. Glial Fibrillary Acidic Protein / biosynthesis

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  • (PMID = 19647039.001).
  • [ISSN] 1872-7972
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; EC 6.3.1.2 / Glutamate-Ammonia Ligase
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45. Phi JH, Park SH, Chae JH, Hong KH, Park SS, Kang JH, Jun JK, Cho BK, Wang KC, Kim SK: Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells. Childs Nerv Syst; 2008 Dec;24(12):1499-503
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  • [Title] Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells.
  • OBJECTS: Congenital Subependymal giant cell astrocytoma (SEGA), diagnosed in fetal and neonatal period, is extremely rare.
  • In double immunofluorescence, the prototype cells of SEGA expressed a variety of neural stem cell (nestin and Sox2) and radial glial cell markers (vimentin and brain lipid-binding protein), in addition to glutamate/aspartate transporter and glial fibrillary acidic protein.
  • [MeSH-major] Astrocytoma / surgery. Cerebral Ventricle Neoplasms / surgery. Fetal Diseases / surgery

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  • (PMID = 18629509.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / FABP7 protein, human; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / Tumor Suppressor Proteins; 0 / Vimentin
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46. Gibson CJ, Parry NM, Jakowski RM, Eshar D: Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris). Vet Pathol; 2008 Nov;45(6):934-8

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  • [Title] Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris).
  • These regions were completely effaced by a moderately cellular infiltration of highly pleomorphic polygonal to spindle shaped cells, mineralization, and necrosis, which were most consistent with anaplastic astrocytoma.
  • A diagnosis of anaplastic astrocytoma was confirmed using immunohistochemical stains that were positive for glial fibrillary acidic protein and S100.
  • [MeSH-major] Astrocytoma / veterinary. Hedgehogs. Spinal Cord Neoplasms / veterinary

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  • (PMID = 18984799.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Jin F, Zhao L, Zhao HY, Guo SG, Feng J, Jiang XB, Zhang SL, Wei YJ, Fu R, Zhao JS: Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes. Neuroscience; 2008 Jun 23;154(2):541-50
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  • [Title] Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes.
  • This study is to explore and compare the features of the cells and cancer stem-like cells (CSCs) isolated from both glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein (MRP) genes.
  • It is a rare report that glioma stem-like cells can be induced successfully from a grade 2-3 astrocytoma tissue.
  • The properties of glioblastoma and astrocytoma stem-like cells on anti-apoptotic and MRP genes are: anti-apoptotic gene livin and survivin are elevated in CSCs but are the most increased in just differentiated CSCs; MRP1 gene is significantly increased and MRP3 is decreased in CSCs, but when differentiating the MRP3 gene starts a remarkable increase in CSCs; the expression of anti-apoptotic and MRP genes shows no differences between the CSCs isolated from glioblastoma and astrocytoma tissues.
  • [MeSH-major] Apoptosis Regulatory Proteins / genetics. Astrocytoma / metabolism. Astrocytoma / pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Drug Resistance, Neoplasm / genetics. Glioblastoma / metabolism. Glioblastoma / pathology. Multidrug Resistance-Associated Proteins / genetics. Neoplastic Stem Cells / metabolism. Neoplastic Stem Cells / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Apoptosis / physiology. Cell Differentiation / physiology. Cell Line, Tumor. Fluorescent Antibody Technique. Glial Fibrillary Acidic Protein / biosynthesis. Glial Fibrillary Acidic Protein / genetics. Glycoproteins / metabolism. Humans. Indicators and Reagents. Intermediate Filament Proteins / biosynthesis. Intermediate Filament Proteins / genetics. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics. Nestin. Peptides / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tubulin / biosynthesis. Tubulin / genetics

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  • (PMID = 18462887.001).
  • [ISSN] 0306-4522
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Apoptosis Regulatory Proteins; 0 / Glial Fibrillary Acidic Protein; 0 / Glycoproteins; 0 / Indicators and Reagents; 0 / Intermediate Filament Proteins; 0 / Multidrug Resistance-Associated Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Peptides; 0 / Tubulin
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48. Wang M, Tihan T, Rojiani AM, Bodhireddy SR, Prayson RA, Iacuone JJ, Alles AJ, Donahue DJ, Hessler RB, Kim JH, Haas M, Rosenblum MK, Burger PC: Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. J Neuropathol Exp Neurol; 2005 Oct;64(10):875-81
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  • [Title] Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma.
  • We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / complications. Brain Neoplasms / pathology. Ependymoma / pathology. Epilepsy / etiology. Glioma / complications. Glioma / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Microscopy, Electron. Mucin-1 / metabolism


49. Takei H, Adesina AM, Powell SZ: Solitary subependymal giant cell astrocytoma incidentally found at autopsy in an elderly woman without tuberous sclerosis complex. Neuropathology; 2009 Apr;29(2):181-6
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  • [Title] Solitary subependymal giant cell astrocytoma incidentally found at autopsy in an elderly woman without tuberous sclerosis complex.
  • Subependymal giant cell astrocytoma (SEGA) is a benign, slowly growing tumor typically occurring in the setting of tuberous sclerosis complex (TSC).
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology
  • [MeSH-minor] Aged. Autopsy. Brain / pathology. Brain / physiopathology. Diagnosis, Differential. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Melanoma / pathology. Melanoma / physiopathology. Melanoma / secondary. Neoplasm Metastasis. Phosphopyruvate Hydratase / metabolism. S100 Proteins / metabolism

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  • (PMID = 18673443.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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50. Hamir AN, Picton R, Blythe LL, Heidel JR: Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor). Vet Pathol; 2008 Nov;45(6):949-51
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  • [Title] Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor).
  • Described are clinical signs and pathologic and immunohistochemical findings in an adult female raccoon (Procyon lotor) with an astrocytoma that involved medulla, cervical spinal cord, and roots of the cervical spinal nerves.
  • Glial fibrillary acidic protein was demonstrated within the neoplastic cells by immunohistochemistry.
  • This appears to be the only reported case of astrocytoma that involved multiple anatomic sites in the central nervous system of this raccoon.
  • [MeSH-major] Astrocytoma / veterinary. Central Nervous System Neoplasms / veterinary. Medulla Oblongata / pathology. Raccoons. Spinal Cord / pathology. Spinal Nerves / pathology

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  • (PMID = 18984803.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Yoshida T, Sasayama H, Nakagawa M: The process of inducing GFAP aggregates in astrocytoma-derived cells is different between R239C and R416W mutant GFAP. A time-lapse recording study. Neurosci Lett; 2009 Jul 10;458(1):11-4
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  • [Title] The process of inducing GFAP aggregates in astrocytoma-derived cells is different between R239C and R416W mutant GFAP. A time-lapse recording study.
  • Alexander disease (ALX) is a rare neurodegenerative disease caused by the gene mutations encoding glial fibrillary acidic protein (GFAP).
  • R239C and R416W GFAP mutations located in the rod domain and tail domain, respectively, were transfected into astrocytoma-derived cells, and their real-time dynamics were observed using time-lapse recording.
  • [MeSH-major] Amino Acids / genetics. Astrocytoma / metabolism. Glial Fibrillary Acidic Protein / genetics. Glial Fibrillary Acidic Protein / metabolism. Point Mutation / physiology

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  • (PMID = 19379794.001).
  • [ISSN] 1872-7972
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Glial Fibrillary Acidic Protein; 147336-22-9 / Green Fluorescent Proteins; 8DUH1N11BX / Tryptophan; 94ZLA3W45F / Arginine; K848JZ4886 / Cysteine
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52. Guo XL, Zhong YF, Sun YH, Liu HH, Jin B, Liang W, Li XS: [Muscle atrophy of hand as an initial sign in a patient with protoplasmic astrocytoma: a case report and literature review]. Beijing Da Xue Xue Bao; 2008 Dec 18;40(6):649-51
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  • [Title] [Muscle atrophy of hand as an initial sign in a patient with protoplasmic astrocytoma: a case report and literature review].
  • We reported a rare case of protoplasmic astrocytoma presenting small muscle atrophy of the right hand as an initial sign.
  • The patient underwent surgical excision and pathological report was protoplasmic astrocytoma, with glial fibrillary acidic protein (GFAP, +++) of immunohistochemical method.
  • We reviewed clinical features, radiological manifestations and pathology of protoplasmic astrocytoma with medical literature documents.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Muscular Atrophy / complications

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  • (PMID = 19088841.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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53. Scarabino T, Giannatempo GM, Nemore F, Popolizio T, Stranieri A: Supratentorial low-grade gliomas. Neuroradiology. J Neurosurg Sci; 2005 Sep;49(3):73-6
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  • In this paper we will illustrate morphological aspects of low-grade supratentorial neoplasms, including tumors of neuroepithelial tissue, such as low-grade diffuse fibrillary astrocytomas, and circumscribed astrocytic lesions (pilocytic astrocytoma, pleomorphic xantoastrocytoma and subependymal giant cell astrocytoma).

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  • (PMID = 16288189.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 14
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54. Kamnasaran D, Qian B, Hawkins C, Stanford WL, Guha A: GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model. Proc Natl Acad Sci U S A; 2007 May 8;104(19):8053-8
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  • [Title] GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model.
  • Malignant astrocytomas are the most common and lethal adult primary brain tumor.
  • Retroviral gene trapping of nontransformed neonatal astrocytes from a glial fibrillary acidic protein (GFAP):(V12)Ha-Ras murine astrocytoma model led to isolation of the transcription factor Gata6.
  • Human malignant astrocytoma cell lines, explant xenografts, and operative specimens demonstrated loss of GATA6 expression.
  • Loss-of-function GATA6 mutations with loss of heterozygosity of the GATA6 locus were found in human malignant astrocytoma specimens but not in lower-grade astrocytomas or normal adult astrocytes.
  • Knockin GATA6 expression in human malignant astrocytoma cells reduced their tumorgenic growth with decreased VEGF expression.
  • Collectively, these data demonstrate that GATA6, isolated from a murine astrocytoma model, is a novel tumor suppressor gene that is a direct target of mutations during malignant progression of murine and human astrocytomas.
  • [MeSH-major] Astrocytoma / genetics. GATA6 Transcription Factor / genetics. Genes, Tumor Suppressor. Glioma / genetics

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  • (PMID = 17463088.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GATA6 Transcription Factor; 0 / GATA6 protein, human; 0 / Gata6 protein, mouse
  • [Other-IDs] NLM/ PMC1876570
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55. Chen AY, Lee H, Hartman J, Greco C, Ryu JK, O'Donnell R, Boggan J: Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma. AJNR Am J Neuroradiol; 2005 Jan;26(1):160-2
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  • [Title] Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma.
  • We report a case of a supratentorial primitive neuroectodermal tumor (PNET) that occurred 12 years after cranial irradiation for a grade II astrocytoma.
  • [MeSH-major] Astrocytoma / radiotherapy. Brain Neoplasms / radiotherapy. Cranial Irradiation. Frontal Lobe. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Second Primary / diagnosis. Neuroectodermal Tumors, Primitive / diagnosis. Supratentorial Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Humans. Radiotherapy, Adjuvant. Synaptophysin / analysis


56. Niranjan R, Kamat PK, Nath C, Shukla R: Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). J Ethnopharmacol; 2010 Feb 17;127(3):625-30

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  • [Title] Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6).
  • AIM OF THE STUDY: The present study was designed to investigate effect of guggulipid, a drug developed by CDRI and nimesulide on LPS stimulated neuroinflammatory changes in rat astrocytoma cell line (C6).
  • MATERIALS AND METHODS: Rat astrocytoma cells (C6) were stimulated with LPS (10 microg/ml) alone and in combinations with different concentrations of guggulipid or nimesulide for 24h of incubation.
  • [MeSH-major] Anti-Inflammatory Agents / pharmacology. Astrocytoma / metabolism. Glial Fibrillary Acidic Protein / metabolism. Inflammation / prevention & control. Inflammation Mediators / metabolism. Plant Extracts / pharmacology. Plant Gums / pharmacology. Sulfonamides / therapeutic use

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20018235.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antioxidants; 0 / Glial Fibrillary Acidic Protein; 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Nitrites; 0 / Plant Extracts; 0 / Plant Gums; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0 / Sulfonamides; 0 / Tumor Necrosis Factor-alpha; 0 / guggulu extract; EC 1.14.99.1 / Cyclooxygenase 2; V4TKW1454M / nimesulide
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57. Shannon P, Sabha N, Lau N, Kamnasaran D, Gutmann DH, Guha A: Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. Am J Pathol; 2005 Sep;167(3):859-67
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  • [Title] Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.
  • We previously characterized a genetically engineered mouse astrocytoma model with embryonic astrocyte-specific, activated (12)V-Ha-RAS (GFAP-RAS) transgenesis.
  • The GFAP-RAS line Ras-B8 appears normal at birth, but 50% of mice die by 4 months from low- and high-grade astrocytomas.
  • We examined the development and progression of astrocytomas in the Ras-B8 genetically engineered mouse.
  • From 3 to 8 weeks the incidence of low-grade astrocytomas progressively increased with 85% of 12-week-old mice harboring low- or high-grade astrocytomas, the latter characterized by increased proliferation, nuclear atypia, and angiogenesis.
  • Tp 53 mutations were detected in both astrocytoma grades, with high-grade astrocytomas expressing elevated levels of epidermal growth factor receptor and vascular endothelial growth factor, plus decreased levels of PTEN and p16, similar to human astrocytomas.
  • Of interest, many of these acquired alterations occur in human astrocytomas, further validating GFAP-RAS as a useful model for studying astrocytoma development and progression.

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  • (PMID = 16127163.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS041097; United States / NINDS NIH HHS / NS / NS41097
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Growth Substances; 0 / Nerve Tissue Proteins; 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC1698742
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58. Ohgaki H, Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol; 2005 Jun;64(6):479-89
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  • While survival rates for pilocytic astrocytomas were excellent (96% at 10 years), the prognosis of diffusely infiltrating gliomas was poorer, with median survival times (MST) of 5.6 years for low-grade astrocytoma WHO grade II, 1.6 years for anaplastic astrocytoma grade III, and 0.4 years for glioblastoma.
  • TP53 mutations were most frequent in gemistocytic astrocytomas (88%), followed by fibrillary astrocytomas (53%) and oligoastrocytomas (44%), but infrequent (13%) in oligodendrogliomas.
  • LOH 1p/19q typically occurred in tumors without TP53 mutations and were most frequent in oligodendrogliomas (69%), followed by oligoastrocytomas (45%), but were rare in fibrillary astrocytomas (7%) and absent in gemistocytic astrocytomas.
  • [MeSH-major] Astrocytoma. Brain Neoplasms. Loss of Heterozygosity. Oligodendroglioma. Tumor Suppressor Protein p53 / genetics


59. Chaichana KL, McGirt MJ, Laterra J, Olivi A, Quiñones-Hinojosa A: Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas. J Neurosurg; 2010 Jan;112(1):10-7
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  • RESULTS: Of the 191 consecutive patients with low-grade gliomas in this series (89 fibrillary astrocytomas, 89 oligodendrogliomas, and 13 mixed gliomas), 83 (43%) and 44 (23%) experienced tumor recurrence and malignant degeneration at last follow-up, respectively.
  • Independent factors associated with malignant degeneration were fibrillary astrocytoma pathology (RR 1.800, 95% CI 1.008-4.928, p = 0.04), tumor size (RR 1.086, 95% CI 1.044-1.358, p = 0.04), and gross-total resection (RR 0.526, 95% CI 0.221-1.007, p = 0.05).
  • [MeSH-minor] Adult. Astrocytoma / pathology. Astrocytoma / surgery. Disease Progression. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Multivariate Analysis. Neoplasm Staging. Oligodendroglioma / pathology. Oligodendroglioma / surgery. Proportional Hazards Models. Retrospective Studies. Risk Factors. Time Factors. Treatment Outcome

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  • (PMID = 19361270.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Yoshida H, Imaizumi T, Lee SJ, Tanji K, Sakaki H, Matsumiya T, Ishikawa A, Taima K, Yuzawa E, Mori F, Wakabayashi K, Kimura H, Satoh K: Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA. Neurosci Res; 2007 Jun;58(2):199-206
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  • [Title] Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA.
  • In the present study, we demonstrated that poly IC enhances the expression of RIG-I in U373MG human astrocytoma cells.
  • [MeSH-major] Astrocytoma / metabolism. Chemokine CCL5 / metabolism. Gene Expression / drug effects. RNA, Double-Stranded / pharmacology. Transcription Factors / metabolism
  • [MeSH-minor] Cell Line, Tumor. Dose-Response Relationship, Drug. Drug Interactions. Enzyme Inhibitors / pharmacology. Enzyme-Linked Immunosorbent Assay. Gene Expression Regulation, Neoplastic / drug effects. Glial Fibrillary Acidic Protein / metabolism. Humans. Imidazoles / pharmacology. Interferon Inducers / pharmacology. Poly I-C / pharmacology. Pyridines / pharmacology. Time Factors

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  • (PMID = 17395328.001).
  • [ISSN] 0168-0102
  • [Journal-full-title] Neuroscience research
  • [ISO-abbreviation] Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Chemokine CCL5; 0 / Enzyme Inhibitors; 0 / Glial Fibrillary Acidic Protein; 0 / Imidazoles; 0 / Interferon Inducers; 0 / Pyridines; 0 / RAI1 protein, human; 0 / RNA, Double-Stranded; 0 / SB 203580; 0 / Transcription Factors; 24939-03-5 / Poly I-C
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61. Odreman F, Vindigni M, Gonzales ML, Niccolini B, Candiano G, Zanotti B, Skrap M, Pizzolitto S, Stanta G, Vindigni A: Proteomic studies on low- and high-grade human brain astrocytomas. J Proteome Res; 2005 May-Jun;4(3):698-708
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  • [Title] Proteomic studies on low- and high-grade human brain astrocytomas.
  • Human brain astrocytomas range from the indolent low-grade to the highly infiltrating and aggressive high-grade form, also known as glioblastoma multiforme.
  • In this study, we compared the protein pattern of low-grade fibrillary astrocytomas to that of glioblastoma multiforme by 2D electrophoresis.
  • Among the proteins more highly expressed in glioblastoma multiforme, we found peroxiredoxin 1 and 6, the transcription factor BTF3, and alpha-B-crystallin, whereas protein disulfide isomerase A3, the catalytic subunit of the cAMP-dependent protein kinase, and the glial fibrillary acidic protein are increased in low-grade astrocytomas.
  • Our findings contribute to deepening our knowledge of the factors that characterize this class of tumors and, at the same time, can be applied toward the development of novel molecular biomakers potentially useful for an accurate classification of the grade of astrocytomas.
  • [MeSH-major] Astrocytoma / chemistry. Neoplasm Proteins / analysis. Proteomics

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  • (PMID = 15952716.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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62. Frenay MP, Fontaine D, Vandenbos F, Lebrun C: First-line nitrosourea-based chemotherapy in symptomatic non-resectable supratentorial pure low-grade astrocytomas. Eur J Neurol; 2005 Sep;12(9):685-90
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  • [Title] First-line nitrosourea-based chemotherapy in symptomatic non-resectable supratentorial pure low-grade astrocytomas.
  • At the present time, there are no proven beneficial effects of chemotherapy (CT) for the treatment of pure low-grade astrocytomas.
  • Brain radiotherapy (RT) still remains the standard treatment in order to reduce or delay tumor progression or symptoms, despite possible long-term neurologic complications.
  • We report 10 patients, with histologically proven pure low-grade fibrillary astrocytomas, to which we administered a first-line nitrosourea-based CT.
  • These results demonstrate that some patients with symptomatic non-resectable fibrillary low-grade astrocytomas can be treated with up-front CT to improve their neurologic status.
  • This report suggests that benefits of CT on symptoms, survival, and quality of life should be prospectively compared with RT.
  • [MeSH-major] Astrocytoma / therapy. Brain Neoplasms / therapy. Drug Therapy / methods. Nitrosourea Compounds / therapeutic use

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  • (PMID = 16128869.001).
  • [ISSN] 1351-5101
  • [Journal-full-title] European journal of neurology
  • [ISO-abbreviation] Eur. J. Neurol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nitrosourea Compounds
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63. Mishra MK, Kumawat KL, Basu A: Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines. Cell Biol Int; 2008 Dec;32(12):1506-13
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  • [Title] Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines.
  • The expression of different proteins such as astrocyte-specific glial fibrillary acidic protein (GFAP), the glutamate aspartate transporter/essential amino acid transporter-1 (GLAST/EAAT-1), glutamate transporter-1/essential amino acid transporter-2 (GLT-1/EAAT-2), Ceruloplasmin and Thioredoxin (TRX) expression level also differ in different human astrocyte cell-lines following infection.
  • [MeSH-minor] Animals. Animals, Newborn. Astrocytoma / immunology. Brain Neoplasms / immunology. Cell Line, Transformed. Cell Line, Tumor. Ceruloplasmin / immunology. Ceruloplasmin / metabolism. Chemokines / immunology. Chemokines / metabolism. Cytokines / immunology. Cytokines / metabolism. Encephalitis Virus, Japanese / immunology. Humans. Mice. Mice, Inbred BALB C. Reactive Oxygen Species / immunology. Reactive Oxygen Species / metabolism. Thioredoxins / immunology. Thioredoxins / metabolism. Vesicular Glutamate Transport Proteins / immunology. Vesicular Glutamate Transport Proteins / metabolism

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  • (PMID = 18801452.001).
  • [ISSN] 1095-8355
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chemokines; 0 / Cytokines; 0 / Reactive Oxygen Species; 0 / Vesicular Glutamate Transport Proteins; 52500-60-4 / Thioredoxins; EC 1.16.3.1 / Ceruloplasmin
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64. Gupta M, Djalilvand A, Brat DJ: Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma. Am J Clin Pathol; 2005 Nov;124(5):755-68
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  • [Title] Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma.
  • Diffuse gliomas are the most common brain tumors and include astrocytomas, oligodendrogliomas, and oligoastrocytomas.
  • Interobserver variability in the diagnosis of diffuse gliomas has been high owing to subjective diagnostic criteria, overlapping morphologic features, and variations in training and practice among pathologists.
  • Combined loss of chromosomes 1p and 19q is a genetic signature of oligodendrogliomas, whereas gains of chromosome 7 in the setting of intact 1p/19q are more typical of astrocytomas.
  • Detection of amplified epidermal growth factor receptor favors the diagnosis of high-grade astrocytomas over anaplastic oligodendroglioma, which is especially relevant for small cell astrocytomas.
  • Strong nuclear staining for p53 often reflects TP53 mutation and is typical of low-grade astrocytomas.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Oligodendroglioma / pathology
  • [MeSH-minor] Biomarkers, Tumor. Genes, p53. Genetic Markers. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Loss of Heterozygosity. Mutation. Receptor, Epidermal Growth Factor / genetics


65. Gururangan S, Fisher MJ, Allen JC, Herndon JE 2nd, Quinn JA, Reardon DA, Vredenburgh JJ, Desjardins A, Phillips PC, Watral MA, Krauser JM, Friedman AH, Friedman HS: Temozolomide in children with progressive low-grade glioma. Neuro Oncol; 2007 Apr;9(2):161-8
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  • Best responses in the 26 patients (86%) with optic pathway glioma (OPG)/pilocytic astrocytoma (PA) included partial response in 3 patients (11%), minor response in 1 (4%), stable disease in 10 (38%), and progressive disease in 12 (46%).
  • Only one of four patients with fibrillary astrocytoma had stable disease for 29 months after TMZ.

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  • (PMID = 17347491.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
  • [Other-IDs] NLM/ PMC1871667
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66. Stokland T, Liu JF, Ironside JW, Ellison DW, Taylor R, Robinson KJ, Picton SV, Walker DA: A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702). Neuro Oncol; 2010 Dec;12(12):1257-68
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  • From the cohort of 798 patients, 639 patients were eligible, with a median age 6.71 years (0.26-16.75 years); 49% were males; 15.9% had neurofibromatosis type 1, 63.7% pilocytic astrocytoma, 5.9% fibrillary astrocytoma, 4.2% mixed neuronal-glial tumors, and 3.6% others; 21.1% were diagnosed clinically.
  • There was a significant association between age and site (P < .001) and extent of tumor resection and site (P < .001).
  • Multivariate analysis identified young age, fibrillary astrocytoma, and extent of surgical resection as significant independent risk factors for progression.
  • In conclusion, the influence of age and anatomical site upon the risk of tumor progression suggests that these factors strongly influence tumor behavior for the majority of pilocytic tumors.
  • Age <1 year and 1-5 years, fibrillary histology, completeness of resection, and chiasmatic location are candidates for stratification in future studies.

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  • (PMID = 20861086.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3018938
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67. Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F: A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma. J Neurooncol; 2010 Oct;100(1):65-71
Hazardous Substances Data Bank. ETOPOSIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diagnoses were clinical in 13 cases and histological in 24, and comprised: pilocytic astrocytoma (17), ganglioglioma (3), pilomyxoid astrocytoma (2), and fibrillary astrocytoma (2).


68. Oshiro S, Tsugu H, Komatsu F, Abe H, Onishi H, Ohmura T, Iwaasa M, Sakamoto S, Fukushima T: Quantitative assessment of gliomas by proton magnetic resonance spectroscopy. Anticancer Res; 2007 Nov-Dec;27(6A):3757-63
MedlinePlus Health Information. consumer health - Brain Tumors.

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  • PATIENTS AND METHODS: Eight patients with histologically verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM, grade 4), 5 cases with anaplastic oligodendroglioma (AO, grade 3; high-grade glioma), and 1 case with fibrillary astrocytoma (FA, grade 2; low-grade glioma) were evaluated using the 1H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively.

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  • (PMID = 17970039.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Protons
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69. Mertsch S, Schmitz N, Jeibmann A, Geng JG, Paulus W, Senner V: Slit2 involvement in glioma cell migration is mediated by Robo1 receptor. J Neurooncol; 2008 Mar;87(1):1-7
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  • Because similar molecular mechanisms may be utilized in glioma cell invasion and neuroblast migration, we studied the expression of Slit2 and its transmembrane receptor Robo1 as well as their functional role in migration in glioma cells. qRT-PCR and immunohistochemistry of human specimens revealed that Slit2 was distinctly expressed by non-neoplastic neurons, but at only very low levels in fibrillary astrocytoma and glioblastoma.

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  • (PMID = 17968499.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Nerve Tissue Proteins; 0 / RNA, Small Interfering; 0 / Receptors, Immunologic; 0 / Slit homolog 2 protein; 0 / roundabout protein
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70. Pipp I, Wagner L, Rössler K, Budka H, Preusser M: Secretagogin expression in tumours of the human brain and its coverings. APMIS; 2007 Apr;115(4):319-26
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  • We detected no secretagogin expression in fibrillary astrocytoma, pilocytic astrocytoma, DNT, pineocytoma, pineoblastoma, subependymal giant cell astrocytoma (SEGA), atypical teratoid/rhabdoid tumour (AT/RT), or primary central nervous system lymphoma (PCNSL).

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  • (PMID = 17504298.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calcium-Binding Proteins; 0 / SCGN protein, human; 0 / Secretagogins
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71. Tchoghandjian A, Fernandez C, Colin C, El Ayachi I, Voutsinos-Porche B, Fina F, Scavarda D, Piercecchi-Marti MD, Intagliata D, Ouafik L, Fraslon-Vanhulle C, Figarella-Branger D: Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature. Brain; 2009 Jun;132(Pt 6):1523-35
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  • [Title] Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature.
  • Pilocytic astrocytomas are WHO grade I gliomas that occur predominantly in childhood.
  • Understanding the molecular basis responsible for the aggressive behaviour of hypothalamo-chiasmatic pilocytic astrocytomas is a prerequisite to setting up new molecular targeted therapies.
  • We used the microarray technique to compare the transcriptional profiles of five hypothalamo-chiasmatic and six cerebellar pilocytic astrocytomas.
  • Results demonstrate that cerebellar and hypothalamo-chiasmatic pilocytic astrocytomas are two genetically distinct and topography-dependent entities.
  • Numerous genes upregulated in hypothalamo-chiasmatic pilocytic astrocytomas also increased in the developing chiasm, suggesting that developmental genes mirror the cell of origin whereas migrative, adhesive and proliferative genes reflect infiltrative properties of these tumours.
  • Of particular interest, NOTCH2, a gene expressed in radial glia and involved in gliomagenesis, was upregulated in hypothalamo-chiasmatic pilocytic astrocytomas.
  • In order to find progenitor cells that could give rise to hypothalamo-chiasmatic pilocytic astrocytomas, we performed a morphological study of the hypothalamo-chiasmatic region and identified, in the floor of the third ventricle, a unique population of vimentin- and glial fibrillary acidic protein-positive cells highly suggestive of radial glia cells.
  • Therefore, pilocytic astrocytomas of the hypothalamo-chiasmatic region should be considered as a distinct entity which probably originates from a unique population of cells with radial glia phenotype.
  • [MeSH-major] Astrocytoma / diagnosis. Optic Nerve Neoplasms / diagnosis

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  • (PMID = 19336457.001).
  • [ISSN] 1460-2156
  • [Journal-full-title] Brain : a journal of neurology
  • [ISO-abbreviation] Brain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Vimentin
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72. Yeaney GA, O'Connor SM, Jankowitz BT, Hamilton RL: A 16-year-old male with a cerebellar mass. Brain Pathol; 2009 Jan;19(1):167-70

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  • An infiltrating component resembling diffuse astrocytoma could be found in areas.
  • Glial fibrillary acidic protein and vimentin were strongly expressed in many cells, while synaptophysin and neurofilament protein were not.
  • [MeSH-major] Astrocytoma / diagnosis. Cerebellar Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Reticulin / metabolism. Vimentin / metabolism

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  • (PMID = 19076785.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Reticulin; 0 / Vimentin
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73. Lymbouridou R, Soufla G, Chatzinikola AM, Vakis A, Spandidos DA: Down-regulation of K-ras and H-ras in human brain gliomas. Eur J Cancer; 2009 May;45(7):1294-303
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  • We evaluated the mutational, mRNA and protein expression profile of the ras genes in 21 glioblastomas multiforme (grade IV), four fibrillary astrocytoma (grade II), four anaplastic astrocytoma (grade III) and 15 normal specimens.
  • K-, H- and N-ras transcript levels were determined by real-time RT-PCR and mutational status by PCR-restriction fragment length polymorphism (RFLP) and direct sequencing. p21 protein was evaluated by Western blot analysis.
  • [MeSH-minor] Adult. Aged. Astrocytoma / genetics. Astrocytoma / metabolism. Astrocytoma / mortality. Blotting, Western / methods. Case-Control Studies. Codon. Female. Gene Expression. Glioblastoma / genetics. Glioblastoma / metabolism. Glioblastoma / mortality. Humans. Male. Middle Aged. Oncogene Protein p21(ras) / analysis. Oncogene Protein p21(ras) / metabolism. Polymorphism, Restriction Fragment Length. Reverse Transcriptase Polymerase Chain Reaction / methods. Statistics, Nonparametric. Survival Rate

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  • (PMID = 19179066.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Codon; EC 3.6.5.2 / Oncogene Protein p21(ras)
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74. Menon G, Nair S, Sudhir J, Rao BR, Krishnakumar K: Bilateral thalamic lesions. Br J Neurosurg; 2010 Oct;24(5):566-71
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  • Biopsy confirmation was possible in six patients and histopathology was suggestive of low grade fibrillary astrocytoma in all six patients.

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  • (PMID = 20536292.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Jalali R, Dutta D, Kamble R, Gupta T, Munshi A, Sarin R, Dinshaw K: Prospective assessment of activities of daily living using modified Barthel's Index in children and young adults with low-grade gliomas treated with stereotactic conformal radiotherapy. J Neurooncol; 2008 Dec;90(3):321-8
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

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  • RESULT: The patient population consisted of 38 patients (male 29, female 9) with a diagnosis of residual or progressive low-grade glioma (pilocytic astrocytoma in 27, fibrillary astrocytoma in 5, ependymoma in 4, and oligodendroglioma and pleomorphic xanthoastrocytoma in 1 each).

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  • (PMID = 18704269.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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76. Wojdas A, Kosek J, Patera J, Jurkiewicz D: [The rare case of nasal glioma]. Otolaryngol Pol; 2005;59(4):617-21
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  • Histopathologic studies confirmed neuroglial tissue--Astrocytoma fibrillare.
  • These tumor cells were immunohistochemically positive for glial fibrillary acidic protein as well as for S-100 protein and vimentin.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. S100 Proteins / analysis. Tomography, X-Ray Computed. Treatment Outcome. Vimentin / analysis

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  • (PMID = 16273873.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Vimentin
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77. Miyata S, Gomi A, Yamaguchi T, Tanaka Y, Watanabe E, Tanaka A: Case of unclassified, radiosensitive, malignant neuroepithelial tumor in the temporal lobe of a child. Brain Tumor Pathol; 2010 Apr;27(1):45-50
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  • On immunohistochemistry, the tumor cells were negative for glial fibrillary acidic protein (GFAP) and synaptophysin and positive for Olig2.
  • The part invading into the surrounding brain showed similarities in form to a highly anaplastic astrocytoma.
  • [MeSH-minor] Astrocytoma. Basic Helix-Loop-Helix Transcription Factors / analysis. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Glial Fibrillary Acidic Protein / analysis. Humans. Ki-67 Antigen / analysis. Neoplasm, Residual. Nerve Tissue Proteins / analysis. Radiotherapy Dosage. Synaptophysin / analysis. Treatment Outcome

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  • (PMID = 20425048.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Nerve Tissue Proteins; 0 / OLIG2 protein, human; 0 / Synaptophysin
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78. Shukla B, Agarwal S, Suri V, Pathak P, Sharma MC, Gupta D, Sharma BS, Suri A, Halder A, Sarkar C: Assessment of 1p/19q status by fluorescence in situ hybridization assay: A comparative study in oligodendroglial, mixed oligoastrocytic and astrocytic tumors. Neurol India; 2009 Sep-Oct;57(5):559-66
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  • Glial fibrillary acidic protein (GFAP), EGFR and p53 were assessed by immunohistochemistry.
  • RESULTS: Glial fibrillary acidic protein immunopositivity was observed in oligodendrogliomas within minigemistocytes and gliofibrillary oligodendrocytes as perinuclear homogenous blobs.
  • Astrocytomas and the astrocytic component of oligoastrocytomas showed a diffuse fibrillary type of staining.
  • None of the astrocytomas including two pediatric cases showed this alteration (P < 0.05).
  • p53 was expressed in 57.1% of astrocytomas (8/14), 33% of mixed oligoastrocytomas (3/9) and 10% of oligodendrogliomas (2/20).
  • In contrast, all astrocytomas (Grade II and III) were EGFR negative.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Chromosomes, Human, Pair 19. In Situ Hybridization, Fluorescence / methods. Oligodendroglioma / genetics
  • [MeSH-minor] Adolescent. Adult. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Male. Middle Aged. Receptor, Epidermal Growth Factor / metabolism. Retrospective Studies. Tumor Suppressor Protein p53 / metabolism. Young Adult

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  • (PMID = 19934553.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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79. Kano T, Ikota H, Wada H, Iwasa S, Kurosaki S: A case of an anaplastic ependymoma with gliosarcomatous components. Brain Tumor Pathol; 2009;26(1):11-7
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  • The tumor was removed, and pathological studies revealed a cerebellar astrocytoma corresponding to World Health Organization grade II.
  • Immunohistochemical findings showed some parts of the sarcomatous components to stain positively for glial fibrillary acidic protein and, as a result, these sarcomatous components were diagnosed to be gliosarcoma.
  • [MeSH-minor] Adult. Astrocytoma / pathology. Astrocytoma / surgery. Female. Glial Fibrillary Acidic Protein / metabolism. Headache / etiology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Paraffin Embedding. Tomography, X-Ray Computed

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  • (PMID = 19408092.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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80. Benesch M, Eder HG, Sovinz P, Raith J, Lackner H, Moser A, Urban C: Residual or recurrent cerebellar low-grade glioma in children after tumor resection: is re-treatment needed? A single center experience from 1983 to 2003. Pediatr Neurosurg; 2006;42(3):159-64
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  • RESULTS: Of 289 patients with CNS tumors referred between 1983 and 2003, 28 (9.7%) (15 male, 13 female; median age at diagnosis: 71 months) had cerebellar LGG (pilocytic astrocytoma grade I: n = 21; fibrillary astrocytoma grade II: n = 5; mixed hamartoma/pilocytic astrocytoma: n = 1; radiographic diagnosis: n = 1).
  • [MeSH-major] Astrocytoma / surgery. Cerebellar Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery

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  • [Copyright] Copyright 2006 S. Karger AG, Basel
  • (PMID = 16636617.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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81. Gill M, Pathak HC, Madan R, Bhattacharya S, Choudhary GS: Primary spinal pleomorphic xanthoastrocytoma. Neurol India; 2010 Sep-Oct;58(5):771-3
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  • Pleomorphic xanthochromic astrocytoma primarily of the spinal cord is a rare entity.
  • [MeSH-major] Astrocytoma / pathology. Neoplasm Recurrence, Local / pathology. Neoplasms, Complex and Mixed. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Magnetic Resonance Imaging. Young Adult

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  • (PMID = 21045509.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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82. Azzalin A, Del Vecchio I, Chiarelli LR, Valentini G, Comincini S, Ferretti L: Absence of interaction between doppel and GFAP, Grb2, PrPc proteins in human tumor astrocytic cells. Anticancer Res; 2005 Nov-Dec;25(6B):4369-74
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  • Recently, Dpl was shown to be aberrantly expressed in astrocytic tumor specimens and in astrocytoma-derived cell lines, showing a peculiar cytoplasmic localization.
  • Our findings provided evidence that, in our astrocytoma cell-based model, Dpl does not share with PrP(C) the ability to interact with GFAP and Grb2.
  • CONCLUSION: Identifying Dpl ligands may provide new insights into the involvement of Dpl in astrocytoma tumor progression.
  • [MeSH-major] Astrocytoma / metabolism. GRB2 Adaptor Protein / metabolism. Glial Fibrillary Acidic Protein / metabolism. PrPC Proteins / metabolism. Prions / metabolism

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  • (PMID = 16309242.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / GRB2 Adaptor Protein; 0 / GRB2 protein, human; 0 / Glial Fibrillary Acidic Protein; 0 / PRND protein, human; 0 / PrPC Proteins; 0 / Prions
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83. Shibahara J, Fukayama M: Secondary glioblastoma with advanced neuronal immunophenotype. Virchows Arch; 2005 Sep;447(3):665-8
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  • We describe an unusual progression of astrocytoma into secondary glioblastoma exhibiting advanced neuronal immunophenotype.
  • A tumor of the left frontal lobe of a 35-year-old man was diagnosed as astrocytoma.
  • Unexpectedly, most of the tumor cells were positive for neuronal markers (synaptophysin and NeuN), but not for glial fibrillary acidic protein (GFAP).
  • This way of malignant progression of astrocytoma was quite unusual.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Glioblastoma / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 15968544.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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84. Gelpi E, Popovic M, Preusser M, Budka H, Hainfellner J: Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis. Neuropathology; 2005 Sep;25(3):241-6
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  • In these cases, the differential diagnosis needs to exclude other malignancies, for example, glioblastoma or malignant fibrous histiocytoma.
  • [MeSH-major] Astrocytoma / pathology. Biomarkers, Tumor / analysis. Brain Neoplasms / pathology. Glial Fibrillary Acidic Protein / metabolism

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  • (PMID = 16193842.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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85. Hlobilkova A, Ehrmann J, Sedlakova E, Krejci V, Knizetova P, Fiuraskova M, Kala M, Kalita O, Kolar Z: Could changes in the regulation of the PI3K/PKB/Akt signaling pathway and cell cycle be involved in astrocytic tumor pathogenesis and progression? Neoplasma; 2007;54(4):334-41
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  • The most frequent alterations found in astrocytomas are two major groups of signaling proteins: the cell cycle and the growth factor-regulated signaling pathways.
  • The aim of our study was to detect changes in expression of the following proteins: the tumor suppressors PTEN, p53, and p21Waf1/Cip1, glial fibrillary acidic protein (GFAP, as a marker of astroglial differentiation), the phosphorylated form of protein kinase B/Akt (PKB/Akt), which is downstream to the epidermal growth factor receptor (EGFR), and MDM2, which degrades p53.
  • Paraffin-embedded astrocytoma tissue samples from 89 patients were divided into low grade (grade I-II; 42 samples) and high grade astrocytomas (grade III-IV; 47 samples).
  • EGFR protein was detected in 29 % of low grade and in 60 % of high grade astrocytomas.
  • The expression of phosphorylated PKB/Akt was found in roughly the same proportions: in 86% of low grade and in 79% of high grade astrocytomas.
  • PTEN was not found in most of astrocytomas, 64% of low grade and 74% of high grade tumors showed no PTEN staining.
  • Overexpression of the mutated form of p53 or loss of p53 expression, however, was found in about 63% in both groups of astrocytomas with no differences between them.
  • GFAP positive tumor cells were detected in only 50% of low grade, and 32% of high grade astrocytomas.
  • We conclude that EGFR expression increases with astrocytoma grading.
  • The alteration of p53 supports the finding that the cell cycle regulation is also disrupted during development of astrocytomas.
  • EGFR is one of the factors, which drives the progression of astrocytomas from low to high grade stage.
  • [MeSH-major] Astrocytoma / metabolism. Cell Cycle. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Signal Transduction
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Glial Fibrillary Acidic Protein / metabolism. Humans. Male. Middle Aged. Mutation / genetics. Oligodendroglioma / metabolism. Oligodendroglioma / pathology. PTEN Phosphohydrolase / metabolism. Phosphorylation. Proto-Oncogene Proteins c-mdm2 / metabolism. Receptor, Epidermal Growth Factor / metabolism. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17822324.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Glial Fibrillary Acidic Protein; 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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86. Mennel HD, Lell B: Ganglioside (GD2) expression and intermediary filaments in astrocytic tumors. Clin Neuropathol; 2005 Jan-Feb;24(1):13-8
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  • The potency of the expression of GD2 is calculated and plotted against the expression of two markers of intermediate glial filaments, namely GFAP (glial fibrillary acid protein) and vimentine.
  • [MeSH-major] Astrocytoma / metabolism. Brain Neoplasms / metabolism. Gangliosides / metabolism. Intermediate Filaments / metabolism
  • [MeSH-minor] Aged. Astrocytes / metabolism. Astrocytes / pathology. Child. Cytoplasm / metabolism. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Male. Middle Aged. Regression Analysis. Tissue Distribution. Vimentin / metabolism

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  • (PMID = 15696779.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Gangliosides; 0 / Glial Fibrillary Acidic Protein; 0 / Vimentin; 65988-71-8 / ganglioside, GD2
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87. Ide T, Miyoshi N, Ochiai K, Yasuda N: Oligoastrocytoma of the brain in a hooded crane (Grus monacha). Vet Pathol; 2009 Mar;46(2):309-12

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  • On histologic examination, the tumor was mainly composed of 2 discrete components that resembled oligodendroglioma and astrocytoma.
  • Immunohistochemistry revealed that the oligodendrogliomatous component cells were partially immunoreactive for vimentin and myelin basic protein, and the astrogliomatous component cells were immunoreactive for vimentin, S-100, and glial fibrillary acidic protein.
  • [MeSH-major] Astrocytoma / veterinary. Bird Diseases / pathology

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  • (PMID = 19261644.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Assimakopoulou M, Kondyli M, Gatzounis G, Maraziotis T, Varakis J: Neurotrophin receptors expression and JNK pathway activation in human astrocytomas. BMC Cancer; 2007;7:202
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  • [Title] Neurotrophin receptors expression and JNK pathway activation in human astrocytomas.
  • The aim of this exploratory study was to investigate the expression levels of neurotrophin receptors, Trks and p75NTR, and the activation of JNK pathway in human astrocytomas and in adjacent non-neoplastic brain tissue.
  • METHODS: Formalin-fixed paraffin-embedded serial sections from 33 supratentorial astrocytomas (5 diffuse fibrillary astrocytomas, WHO grade II; 6 anaplastic astrocytomas, WHO grade III; 22 glioblastomas multiforme, WHO grade IV) were immunostained following microwave pretreatment.
  • CONCLUSION: In the context of astrocytomas, Trk receptors (TrkA, TrkB, TrkC) expression may promote tumor growth independently of grade.
  • Considering the fact that regional tumor heterogeneity may be a limiting factor for immunohistochemical studies, the significance of the reverse relationship between Trk receptors and pc-Jun/pJNK LIs with respect to biological behavior of human astrocytomas requires further evaluation.
  • [MeSH-major] Astrocytoma / metabolism. Brain Neoplasms / metabolism. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. MAP Kinase Kinase 4 / metabolism. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics. Receptors, Nerve Growth Factor / biosynthesis. Receptors, Nerve Growth Factor / genetics

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  • (PMID = 17971243.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / NGFR protein, human; 0 / Nerve Tissue Proteins; 0 / Receptors, Nerve Growth Factor; 0 / bcl-2-Associated X Protein; EC 2.7.10.1 / Receptor, trkA; EC 2.7.10.1 / Receptor, trkB; EC 2.7.10.1 / Receptor, trkC; EC 2.7.12.2 / MAP Kinase Kinase 4
  • [Other-IDs] NLM/ PMC2180182
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89. Takei H, Goodman JC, Tanaka S, Bhattacharjee MB, Bahrami A, Powell SZ: Pituicytoma incidentally found at autopsy. Pathol Int; 2005 Nov;55(11):745-9
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  • Microscopically, whole-mounted sections revealed a well-circumscribed nodule with no fibrous capsule, located mainly in the neurohypophysis and partially compressing the adenohypophysis.
  • The tumor was composed primarily of bipolar, occasionally unipolar, cells with syncytial fibrillary cytoplasm, arranged in short curvilinear fascicles and/or storiform patterns.
  • Immunohistochemically, the tumor showed diffuse strong expression of glial fibrillary acidic protein, S-100 protein, and vimentin.
  • Distinction from other intrasellar tumors (granular cell tumor and pilocytic astrocytoma) is important.
  • [MeSH-minor] Antigens, CD56 / analysis. Antigens, CD56 / immunology. Autopsy. Female. Glial Fibrillary Acidic Protein / analysis. Glial Fibrillary Acidic Protein / immunology. Humans. Immunohistochemistry. Middle Aged. Mucin-1 / analysis. Mucin-1 / immunology. Pituitary Gland, Posterior / chemistry. Pituitary Gland, Posterior / pathology. S100 Proteins / analysis. S100 Proteins / immunology. Vimentin / analysis. Vimentin / immunology

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  • (PMID = 16271088.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin
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90. Pérez-Gómez JL, Rodríguez-Alvarez CA, Marhx-Bracho A, Rueda-Franco F: Stereotactic biopsy for brainstem tumors in pediatric patients. Childs Nerv Syst; 2010 Jan;26(1):29-34
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  • The histopathology was anaplastic astrocytoma (30%), followed by fibrillary and pilocytic types (25% each), low-grade astrocytoma (5%), high-grade astrocytoma (5%), and normal tissue (10%).
  • [MeSH-major] Astrocytoma / pathology. Biopsy / methods. Brain Stem / pathology. Brain Stem Neoplasms / pathology. Stereotaxic Techniques

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  • (PMID = 19784659.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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91. Parwani AV, Baisden BL, Erozan YS, Burger PC, Ali SZ: Pineal gland lesions: a cytopathologic study of 20 specimens. Cancer; 2005 Apr 25;105(2):80-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The 20 specimens include pineoblastoma (five specimens), pineocytoma (four specimens), astrocytoma (three specimens), germ cell tumor (three specimens), meningioma (one specimen), epidermoid cyst (three specimens), and pineal cyst (one specimen).
  • In selected specimens, immunoperoxidase (IPOX) stains were performed on cell block sections using synaptophysin, neuron-specific enolase, placental alkaline phosphatase, glial fibrillary acidic protein, leukocyte common antigen, cytokeratins, and human chorionic gonadotropin antibodies.
  • The unique features included the following: small, hyperchromatic, round to oval cells with frequent rosetting (pineocytoma), with a few specimens in addition showing hypercellularity, crowding, mitoses, and necrosis (pineoblastoma); pleomorphic round cells in a fibrillary background (astrocytoma); large polygonal cells with prominent nucleoli and clear cytoplasm (germ cell tumor); spindled fibroblastic cells (meningioma); anucleate squames and mature squamous cells (epidermoid cyst); and small uniform polygonal cells (pineal cyst).
  • When necessary, IPOX studies supported the morphologic diagnoses.
  • [MeSH-minor] Adolescent. Adult. Astrocytoma / pathology. Biopsy, Fine-Needle. Child. Child, Preschool. Diagnosis, Differential. Epidermal Cyst / pathology. Female. Germinoma / pathology. Humans. Infant. Male. Middle Aged

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  • [Copyright] 2005 American Cancer Society.
  • (PMID = 15662708.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Lee FY, Jan YJ, Wen MC, Li MC, Wang J, Wen-Hsien C: A 32-year-old man with a fourth ventricular mass. Brain Pathol; 2009 Apr;19(2):333-6

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  • The features noted are suggestive of a probable better prognosis in this variant of low-grade astrocytoma.
  • [MeSH-major] Astrocytoma / pathology. Cerebral Ventricle Neoplasms / pathology
  • [MeSH-minor] Adult. Glial Fibrillary Acidic Protein / metabolism. Humans. Magnetic Resonance Imaging. Male. S100 Proteins / metabolism

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  • (PMID = 19291000.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
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93. Naranjo C, Schobert C, Dubielzig R: Canine ocular gliomas: a retrospective study. Vet Ophthalmol; 2008 Nov-Dec;11(6):356-62
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  • Immunohistochemistry for Glial Fibrillary Acidic Protein (GFAP) was performed in all cases.
  • One neoplasm was classified as low-grade astrocytoma, 5 tumors as medium-grade astrocytoma, 11 tumors as high grade-astrocytoma and 1 tumor as oligodendroglioma.
  • [MeSH-minor] Animals. Brain Neoplasms / secondary. Diagnosis, Differential. Dogs. Eye Enucleation / veterinary. Female. Glial Fibrillary Acidic Protein / immunology. Immunohistochemistry / veterinary. Male. Neoplasm Invasiveness. Prognosis. Retrospective Studies. Risk Factors

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  • (PMID = 19046275.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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94. Lacoste-Collin L, d'Aure D, Aziza J, Quintyn ML, Uro-Coste E, Courtade-Saïdi M: Cerebrospinal fluid cytologic findings of a pleomorphic xanthoastrocytoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):871-4
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  • Characteristic histologic features include pleomorphic tumor cells and lipidized cells expressing glial fibrillary acidic protein (GFAP), corresponding to a World Health Organization grade 2 tumor.
  • [MeSH-major] Astrocytoma / cerebrospinal fluid. Astrocytoma / pathology. Brain Neoplasms / cerebrospinal fluid. Brain Neoplasms / pathology

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  • (PMID = 21053559.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Maramattom BV, Giannini C, Manno EM, Wijdicks EF, Campeau NG: Gliomatosis cerebri angiographically mimicking central nervous system angiitis: case report. Neurosurgery; 2006 Jun;58(6):E1209; discussion E1209
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  • The biopsy revealed a Grade 2 fibrillary astrocytoma consistent with gliomatosis cerebri.

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  • (PMID = 16723870.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Porto L, Kieslich M, Franz K, Lehrbecher T, Pilatus U, Hattingen E: Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas. Brain Tumor Pathol; 2010 Oct;27(2):65-70
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  • Our purpose was to investigate whether in vivo proton magnetic resonance spectroscopic imaging, using normalized concentrations of total choline (tCho) and total creatine (tCr), can differentiate between WHO grade I pilocytic astrocytoma (PA) and diffuse, fibrillary WHO grade II astrocytoma (DA) in children.
  • Data from 16 children with astrocytomas (11 children with PA and 5 children with DA) were evaluated retrospectively.
  • MRS was performed before treatment in all patients with histologically proven low-grade astrocytomas.
  • We concluded that choline as a single parameter is not reliable in the differential diagnosis of low-grade astrocytomas in children.
  • [MeSH-minor] Adolescent. Astrocytoma / diagnosis. Astrocytoma / metabolism. Astrocytoma / pathology. Brain / pathology. Child. Child, Preschool. Choline / metabolism. Creatine / metabolism. Diagnosis, Differential. Female. Humans. Infant. Infratentorial Neoplasms / metabolism. Infratentorial Neoplasms / pathology. Magnetic Resonance Spectroscopy. Male. Supratentorial Neoplasms / metabolism. Supratentorial Neoplasms / pathology

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  • (PMID = 21046307.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] MU72812GK0 / Creatine; N91BDP6H0X / Choline
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97. Rogério F, Queiroz Lde S, de Lima MS, Kaleff PR, Vargas AA: Temporal pleomorphic xanthoastrocytoma with glycogen accumulation--case report. Clin Neuropathol; 2008 Jul-Aug;27(4):234-40
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  • The tumor was immunoreactive for glial fibrillary acidic protein and vimentin.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Glycogen / metabolism. Inclusion Bodies / pathology
  • [MeSH-minor] Adolescent. Antigens, CD34 / metabolism. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Seizures / etiology. Tomography, X-Ray Computed. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18666439.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Glial Fibrillary Acidic Protein; 0 / Tumor Suppressor Protein p53; 9005-79-2 / Glycogen
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98. Lee D, Suh YL, Nam DH: Cerebral granular cell tumor. Neuropathology; 2008 Aug;28(4):417-21
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  • Despite these wide immunoexpressions and the lack of any association with astrocytoma, the histogenesis of cerebral GCTs is still suggested to be of a glial origin, based on the tumor location, the GFAP positivity and the ultrastructural findings, of which the latter showed intermediate filaments, and these are reminiscent of neoplastic astrocytes.
  • [MeSH-minor] Astrocytoma / pathology. Diagnosis, Differential. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged

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  • (PMID = 18466222.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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99. Zeng Y, Yang Z, Xu JG, Yang MS, Zeng ZX, You C: Differentially expressed genes from the glioblastoma cell line SHG-44 treated with all-trans retinoic acid in vitro. J Clin Neurosci; 2009 Feb;16(2):285-94
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  • Morphology, immunocytochemistry, growth curve assay, and flow cytometry were used to investigate the effects of all-trans retinoic acid (RA) on cell proliferation, cell cycle progression and differentiation of the astrocytoma cell line SHG-44 from glioblastoma multiforme (World Health Organization grade IV).
  • The expression of glial fibrillary acidic protein (GFAP) was markedly increased in RA-treated SHG-44 cells.
  • [MeSH-minor] Cell Cycle / drug effects. Cell Line, Tumor. Cell Proliferation / drug effects. Flow Cytometry / methods. Glial Fibrillary Acidic Protein / metabolism. Glioblastoma / pathology. Glioblastoma / physiopathology. Humans. Oligonucleotide Array Sequence Analysis / methods

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  • (PMID = 19091570.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Glial Fibrillary Acidic Protein; 5688UTC01R / Tretinoin
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100. Shostak KO, Dmitrenko VV, Vudmaska MI, Naidenov VG, Beletskii AV, Malisheva TA, Semenova VM, Zozulya YP, Demotes-Mainard J, Kavsan VM: Patterns of expression of TSC-22 protein in astrocytic gliomas. Exp Oncol; 2005 Dec;27(4):314-8
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  • RESULTS: Immunohistochemical analysis has shown that the number of cells expressing TSC-22 was significantly lower in glioblastoma tissues than that in diffuse astrocytoma.
  • [MeSH-major] Astrocytoma / metabolism. Brain Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Repressor Proteins / biosynthesis
  • [MeSH-minor] Amino Acid Sequence. Astrocytes / metabolism. Base Sequence. Biomarkers, Tumor / analysis. Gene Expression Profiling. Glial Fibrillary Acidic Protein / biosynthesis. Humans. Immunohistochemistry. Microglia / metabolism. Molecular Sequence Data. Recombinant Proteins / biosynthesis. Recombinant Proteins / genetics

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  • (PMID = 16404353.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Recombinant Proteins; 0 / Repressor Proteins; 0 / TSC22D1 protein, human
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