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1. Maria BL, Gupta N, Gilg AG, Abdel-Wahab M, Leonard AP, Slomiany M, Wheeler WG, Tolliver LB, Babcock MA, Lucas JT Jr, Toole BP: Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas. J Child Neurol; 2008 Oct;23(10):1214-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas.
  • Although significant advances have been made in treating malignant pediatric central nervous system tumors such as medulloblastoma, no effective therapy exists for diffuse pontine glioma or intramedullary spinal astrocytoma.
  • Biology of these 2 tumors is poorly understood, in part because diffuse pontine gliomas are not treated surgically, and tumor specimens from intramedullary spinal astrocytomas are rare and minuscule.
  • We review the clinical course of pediatric intramedullary spinal astrocytoma and diffuse pontine glioma, and show expression of membrane proteins that interact with hyaluronan: CD44, extracellular matrix metalloproteinase inducer, and breast cancer resistance protein (BCRP/ABCG2).

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  • (PMID = 18952588.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R13 NS040925; United States / NCI NIH HHS / CA / R01 CA073839; United States / NINDS NIH HHS / NS / 5R13NS040925-09; United States / NCRR NIH HHS / RR / C06RR015455; United States / NCI NIH HHS / CA / R01 CA082867; United States / NCI NIH HHS / CA / CA073839; United States / NCRR NIH HHS / RR / C06 RR015455; United States / NCI NIH HHS / CA / CA082867
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / Antigens, CD44; 0 / BSG protein, human; 0 / Neoplasm Proteins; 136894-56-9 / Antigens, CD147; 9004-61-9 / Hyaluronic Acid
  • [Number-of-references] 23
  • [Other-IDs] NLM/ NIHMS463105; NLM/ PMC3641563
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2. Yamagishi S, Koyama Y, Katayama T, Taniguchi M, Hitomi J, Kato M, Aoki M, Itoyama Y, Kato S, Tohyama M: An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation. PLoS One; 2007;2(10):e1030
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  • [Title] An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation.
  • Neuronal Lewy body-like hyaline inclusions (LBHI) and astrocytic hyaline inclusions (Ast-HI) containing mutant Cu/Zn superoxide dismutase 1 (SOD1) are morphological hallmarks of familial amyotrophic lateral sclerosis (FALS) associated with mutant SOD1.
  • Moreover, in spinal cord neurons of L84V SOD1 transgenic mice at presymptomatic stage, we observed aberrant aggregation of ER and numerous free ribosomes associated with abnormal inclusion-like structures, presumably early stage neuronal LBHI.
  • [MeSH-minor] Animals. Cell Line, Tumor. Golgi Apparatus / metabolism. Humans. In Vitro Techniques. Lysosomes / metabolism. Mice. Mice, Transgenic. Ribosomes / metabolism. Ubiquitin / chemistry

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  • (PMID = 17925878.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ubiquitin; EC 1.15.1.- / superoxide dismutase 1; EC 1.15.1.1 / Superoxide Dismutase
  • [Other-IDs] NLM/ PMC2000355
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3. Jang SY, Kong MH, Song KY, Frazee JG: Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult. J Korean Neurosurg Soc; 2009 Jun;45(6):381-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult.
  • The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report.
  • Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord.
  • The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II).
  • When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

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  • (PMID = 19609424.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2711238
  • [Keywords] NOTNLM ; Astrocytoma / Cranial metastases / Intramedullary / Spinal cord tumor
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4. Mendonça R, Lima LG, Fernandes LN, Ferreira NP, De Napoli G: [Primary connus medullaris glioblastoma: case report]. Arq Neuropsiquiatr; 2005 Jun;63(2B):539-42
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  • [Transliterated title] Glioblastoma primário de cone medula: relato de caso.
  • Glioblastomas are the most common type of brain tumors; astrocytic in their origin, they are anaplastic tumors, and are located mainly in the cerebral hemispheres.
  • Primary growth in the conus medullaris is very rare, and the assessment and prognosis of this kind of tumor are distinct and unique.
  • We present here the case of a 39 years-old man with an intramedullary tumor of the spinal cord, with an histo pathological diagnosis of glioblastoma, along with some therapeutic considerations.
  • [MeSH-major] Glioblastoma / diagnosis. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 16059615.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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5. Carmen J, Rothstein JD, Kerr DA: Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain Res; 2009 Mar 31;1263:143-54
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  • [Title] Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis.
  • Neuroadapted Sindbis virus (NSV) is a neuronotropic virus that causes a fulminant encephalomyelitis in susceptible mice due to death of motor neurons in the brain and spinal cord.
  • We and others have found that uninfected motor neurons die in response to NSV infection, at least in part due to disrupted astrocytic glutamate transport, resulting in excitotoxic motor neuron death.
  • Treatment of organotypic slice cultures with NSV results in viral replication, cell death, altered astrocyte morphology, and the downregulation of the astrocytic glutamate transporter, GLT-1.
  • Furthermore, TNF-alpha deficient mice infected with NSV exhibit neither GLT-1 downregulation nor neuronal death of brainstem and cervical spinal cord motor neurons and have markedly reduced mortality.

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  • (PMID = 19368827.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS052179; United States / NINDS NIH HHS / NS / NS052179-05; United States / NINDS NIH HHS / NS / R01 NS033958-09; United States / NINDS NIH HHS / NS / R01 NS033958; United States / NINDS NIH HHS / NS / R01 NS052179-05; United States / NINDS NIH HHS / NS / NS033958-09
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Transporter 2; 0 / Tumor Necrosis Factor-alpha; 3KX376GY7L / Glutamic Acid
  • [Other-IDs] NLM/ NIHMS135641; NLM/ PMC2952353
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6. Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T: Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation. Neuro Oncol; 2009 Aug;11(4):446-51
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic neoplasm of the brain.
  • A 47-year-old woman presented with an epileptic seizure due to a large tumor in the right frontal lobe.
  • The tumor was resected and diagnosed as PXA with anaplastic features.
  • Two years later, the patient developed a tumor nodule in the cervical spinal cord that histologically corresponded to a small-cell glioma with high cellularity and prominent MIB-1 (mindbomb homolog 1) labeling.
  • In the following months, multiple nodular lesions appeared throughout the CNS, and STI was performed six times for eight intracranial lesions using Gamma Knife and twice using a linear accelerator, for three spinal cord lesions in total.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Middle Aged. Prognosis

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  • (PMID = 19164434.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2743225
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7. Komotar RJ, Carson BS, Rao C, Chaffee S, Goldthwaite PT, Tihan T: Pilomyxoid Astrocytoma of the Spinal Cord: Report of Three Cases. Neurosurgery; 2005 Jan 01;56(1):E206-E210

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid Astrocytoma of the Spinal Cord: Report of Three Cases.

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  • (PMID = 28184642.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP: Prognosis and treatment of spinal cord astrocytoma. Int J Radiat Oncol Biol Phys; 2009 Mar 1;73(3):727-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognosis and treatment of spinal cord astrocytoma.
  • PURPOSE: To identify the prognostic factors for spinal cord astrocytoma and determine the effects of surgery and radiotherapy on outcome.
  • METHODS AND MATERIALS: This retrospective study reviewed the cases of consecutive patients with spinal cord astrocytoma treated at Mayo Clinic Rochester between 1962 and 2005.
  • Of these 136 patients, 69 had pilocytic and 67 had infiltrative astrocytoma.
  • CONCLUSION: The results of our study have shown that histologic type is the most important prognostic variable affecting the outcome of spinal cord astrocytomas.
  • [MeSH-major] Astrocytoma / radiotherapy. Astrocytoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery

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  • (PMID = 18687533.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Katoh N, Shirato H, Aoyama H, Onimaru R, Suzuki K, Hida K, Miyasaka K, Iwasaki Y: Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. J Neurooncol; 2006 May;78(1):63-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor.
  • PURPOSE: To retrospectively analyze the outcome of post-operative radiotherapy for spinal cord glioma with the emphasis on the hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumors.
  • MATERIALS AND METHODS: Forty-one patients with spinal cord glioma received post-operative radiotherapy between 1979 and 2003.
  • There were 12 low-grade astrocytic tumors, 11 high-grade astrocytic tumors, 16 low-grade ependymal tumors and 2 high-grade ependymal tumors.
  • Among 11 patients with high-grade astrocytic tumors, 5 with anaplastic astrocytoma and 1 with glioblastoma received hypofractionated radiotherapy boost for dose escalation.
  • RESULTS: The Kaplan-Meier survival rates at 10 years from the date of the first surgery were 64% for the entire group, 47% for the astrocytic tumors and 84% for the ependymal tumors, respectively (P=0.009).
  • Among 11 patients with high-grade astrocytic tumors, the actuarial survival rate at 10 years was 35%.
  • DISCUSSION: The results for ependymal tumors and low-grade astrocytic tumors were comparable to those reported in the literature.
  • Hypofractionated radiotherapy boost for dose escalation may help to prolong the survival of patients with high-grade astrocytic tumors.
  • [MeSH-major] Dose Fractionation. Glioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy

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  • (PMID = 16314938.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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10. Robinson CG, Prayson RA, Hahn JF, Kalfas IH, Whitfield MD, Lee SY, Suh JH: Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord. Int J Radiat Oncol Biol Phys; 2005 Sep 1;63(1):91-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord.
  • PURPOSE: To determine survival and changes in neurologic function and Karnofsky performance status (KPS) in a series of patients treated for low-grade astrocytoma of the spinal cord during the past two decades.
  • METHODS: This study consisted of 14 patients with pathologically confirmed low-grade astrocytoma of the spinal cord who were treated between 1980 and 2003.
  • Neither overall survival nor progression-free survival was clearly correlated with any patient, tumor, or treatment factors.
  • CONCLUSION: Patients who undergo gross total resection of their tumor may be followed closely.
  • [MeSH-major] Astrocytoma / mortality. Spinal Cord Neoplasms / mortality

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  • (PMID = 16111576.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Komotar RJ, Carson BS, Rao C, Chaffee S, Goldthwaite PT, Tihan T: Pilomyxoid astrocytoma of the spinal cord: report of three cases. Neurosurgery; 2005;56(1):191
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid astrocytoma of the spinal cord: report of three cases.
  • OBJECTIVE AND IMPORTANCE: Pilomyxoid astrocytoma (PMA) is a recently described, rare, circumscribed glioma similar to pilocytic astrocytoma.
  • Despite its circumscribed nature, PMA implies a worse overall outcome than typical pilocytic astrocytoma.
  • Since these original reports, we have encountered three tumors in the spinal cord with histological features identical to those of PMA.
  • INTERVENTION: The first patient's cervical and thoracic neoplasm was treated with subtotal resection and multiple laminectomies and spinal fusion for recurrence.
  • The neonate underwent laminectomy and biopsy of his holocord tumor.
  • The cases presented in this report suggest that PMA can occur at a later age and can involve the spinal cord.
  • [MeSH-major] Astrocytoma
  • [MeSH-minor] Child. Humans. Infant, Newborn. Male. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / surgery

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  • (PMID = 15617606.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Larson DB, Hedlund GL: Non-enhancing pilocytic astrocytoma of the spinal cord. Pediatr Radiol; 2006 Dec;36(12):1312-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-enhancing pilocytic astrocytoma of the spinal cord.
  • Pilocytic astrocytomas are among the most common intramedullary spinal cord tumors in the pediatric age group.
  • The presence of contrast enhancement is a major factor used to distinguish these tumors from other spinal cord lesions.
  • We present a case of histologically proved non-enhancing intramedullary spinal cord pilocytic astrocytoma in a 12-year-old girl.
  • This case represents an exception to the conventional wisdom that pediatric spinal neoplasms enhance with administration of intravenous contrast material.
  • [MeSH-major] Astrocytoma / diagnosis. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 17021719.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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13. Sajadi A, Janzer RC, Lu TL, Duff JM: Pilomyxoid astrocytoma of the spinal cord in an adult. Acta Neurochir (Wien); 2008 Jul;150(7):729-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid astrocytoma of the spinal cord in an adult.
  • We report a 45-year old woman with a pilomyxoid astrocytoma (PMA) of the cervical spinal cord with a rapid clinical course and fatal outcome.
  • [MeSH-major] Astrocytoma / genetics. Spinal Cord Neoplasms / genetics

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  • (PMID = 18536992.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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14. Arulrajah S, Huisman TA: Pilomyxoid astrocytoma of the spinal cord with cerebrospinal fluid and peritoneal metastasis. Neuropediatrics; 2008 Aug;39(4):243-5
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  • [Title] Pilomyxoid astrocytoma of the spinal cord with cerebrospinal fluid and peritoneal metastasis.
  • Pilomyxoid astrocytoma (PMA) is a recently described rare tumor which is a variant of pilocytic astrocytoma (PA).
  • Spinal cord PMA has been reported in two articles in the past and none of the reported case had extraneural metastasis.
  • We report on a female child with cervical cord PMA with diffuse leptomeningeal metastasis involving the brain and spinal cord.
  • Two years later she presented with peritoneal carcinomatoses which was consistent with metastatic tumor via a ventriculoperitoneal (VP) shunt.
  • [MeSH-major] Astrocytoma / cerebrospinal fluid. Astrocytoma / pathology. Carcinoma / secondary. Peritoneal Neoplasms / secondary. Spinal Cord Neoplasms / cerebrospinal fluid. Spinal Cord Neoplasms / pathology

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  • (PMID = 19165714.001).
  • [ISSN] 0174-304X
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Hassan F, Paluzzi A, Kayello R, Bradey N, Strachan RD: Hydrocephalus as presenting feature of spinal astrocytoma in a adolescent patient. Br J Neurosurg; 2008 Jun;22(3):433-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hydrocephalus as presenting feature of spinal astrocytoma in a adolescent patient.
  • We report the case of an adolescent with a thoracic spine astrocytoma whose initial presentation was communicating hydrocephalus.
  • We speculate that the mechanism may be reduced meningeal compliance due to meningeal spread of the tumour.
  • [MeSH-major] Astrocytoma / complications. Hydrocephalus / etiology. Spinal Cord Neoplasms / complications

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  • (PMID = 18568734.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Rothman SM, Winkelstein BA: Cytokine antagonism reduces pain and modulates spinal astrocytic reactivity after cervical nerve root compression. Ann Biomed Eng; 2010 Aug;38(8):2563-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokine antagonism reduces pain and modulates spinal astrocytic reactivity after cervical nerve root compression.
  • Relationships between nerve root compression, behavioral sensitivity, spinal cytokines, and glial reactivity are not fully defined for painful cervical nerve root compression.
  • Spinal cytokines were quantified after mechanical root compression (10gf), root exposure to inflammatory chromic gut material (chr), the combination of both insults together (10gf + chr) or sham.
  • Spinal astrocytic reactivity significantly decreased for both treatments after 10gf (p < 0.002); but, only IL-1ra following 10gf + chr significantly reduced astrocytic reactivity (p < 0.001).
  • Early increases in spinal TNFalpha, IL-1beta, and IL-1alpha may induce pain, affect spinal astrocytic responses, and appear to have differential effects in mediating the behavioral hypersensitivity produced by different types of painful cervical radicular injuries.
  • [MeSH-minor] Animals. Interleukin 1 Receptor Antagonist Protein. Interleukin-1. Interleukin-1beta / metabolism. Male. Neck Injuries / physiopathology. Neuroglia / metabolism. Rats. Rats, Sprague-Dawley. Spinal Cord Compression / physiopathology. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 20309734.001).
  • [ISSN] 1573-9686
  • [Journal-full-title] Annals of biomedical engineering
  • [ISO-abbreviation] Ann Biomed Eng
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin 1 Receptor Antagonist Protein; 0 / Interleukin-1; 0 / Interleukin-1beta; 0 / Tumor Necrosis Factor-alpha
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17. Gibson CJ, Parry NM, Jakowski RM, Eshar D: Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris). Vet Pathol; 2008 Nov;45(6):934-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris).
  • Grossly, the bladder was large and flaccid and the cervical and lumbar spinal cord were regionally enlarged, light grey, and friable with multifocal hemorrhages.
  • The thoracic spinal cord was grossly normal.
  • Microscopically all regions of the spinal cord had similar changes, although the cervical and lumbar sections were most severely affected.
  • These regions were completely effaced by a moderately cellular infiltration of highly pleomorphic polygonal to spindle shaped cells, mineralization, and necrosis, which were most consistent with anaplastic astrocytoma.
  • The thoracic spinal cord white matter was similarly infiltrated by the neoplastic cells, with perivascular extension into the otherwise normal grey matter.
  • A diagnosis of anaplastic astrocytoma was confirmed using immunohistochemical stains that were positive for glial fibrillary acidic protein and S100.
  • [MeSH-major] Astrocytoma / veterinary. Hedgehogs. Spinal Cord Neoplasms / veterinary

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  • (PMID = 18984799.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Anan M, Inoue R, Ishii K, Abe T, Fujiki M, Kobayashi H, Goya T, Nakazato Y: A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord. Hum Pathol; 2009 Jun;40(6):898-901

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rosette-forming glioneuronal tumor of the spinal cord: the first case of a rosette-forming glioneuronal tumor originating from the spinal cord.
  • This report presents the first case of a rosette-forming glioneuronal tumors arising from the spinal cord.
  • Magnetic resonance imaging demonstrated a mass in the cervicothoracic spinal cord that suggested an intramedullary spinal tumor.
  • A total gross resection of the tumor was performed.
  • As is typical of rosette-forming glioneuronal tumors of the fourth ventricle, this spinal cord example manifested neurocytic and astrocytic components.
  • The astrocytic component showed characteristic features of a pilocytic astrocytoma, as is often the case in the fourth ventricle examples.
  • [MeSH-major] Cerebral Ventricle Neoplasms / pathology. Fourth Ventricle / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adult. Astrocytoma / pathology. Female. Humans. Rosette Formation

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  • [CommentIn] Hum Pathol. 2009 Oct;40(10):1510; author reply 1510 [19616823.001]
  • (PMID = 19269010.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Vassilyadi M, Michaud J: Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread. Pediatr Neurosurg; 2005 Jan-Feb;41(1):29-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread.
  • The lesion was subtotally resected (70%) and diagnosed as an astrocytoma (mostly Kernohan grade 2 but with areas of grade 3).
  • Chemotherapy was administered and follow-up spine MRI at 2 months did not reveal any residual tumor, however, the leptomeningeal enhancement persisted.
  • This case illustrates how a spinal cord astrocytoma can metastasize via spinocranial dispersion and present early with hydrocephalus rather than myelopathy.
  • [MeSH-major] Astrocytoma / pathology. Hydrocephalus / etiology. Meningeal Neoplasms / complications. Meningeal Neoplasms / secondary. Neoplastic Cells, Circulating. Spinal Cord Neoplasms / pathology

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15886510.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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20. Yoshino M, Morita A, Shibahara J, Kirino T: Radiation-induced spinal cord cavernous malformation. Case report. J Neurosurg; 2005 Jan;102(1 Suppl):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation-induced spinal cord cavernous malformation. Case report.
  • The authors report a case of a 16-year-old girl who presented with progressive gait difficulty 8 years after undergoing spinal radiation therapy for spinal astrocytoma.
  • This is believed to be the third case of de novo formation of an intramedullary cavernous malformation following spinal radiation therapy.
  • [MeSH-major] Arteriovenous Malformations / etiology. Radiation Injuries / pathology. Spinal Cord Diseases / etiology
  • [MeSH-minor] Adolescent. Astrocytoma / radiotherapy. Female. Humans. Spinal Cord Neoplasms / radiotherapy. Time Factors

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  • (PMID = 16206743.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Aoyama T, Hida K, Ishii N, Seki T, Ikeda J, Iwasaki Y: Intramedullary spinal cord germinoma--2 case reports. Surg Neurol; 2007 Feb;67(2):177-83; discussion 183
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord germinoma--2 case reports.
  • BACKGROUND: Primary intramedullary spinal cord germinoma is very rare.
  • We encountered 2 patients with primary intramedullary spinal cord germinoma.
  • We describe herein our comprehensive management system for CNS germinoma, including intramedullary spinal cord germinoma, along with a review of the literature.
  • Magnetic resonance imaging demonstrated marked cord swelling between T9 and T12, with slight enhancement in the spinal cord.
  • Astrocytic tumor was initially suspected, and partial removal was performed.
  • Magnetic resonance imaging demonstrated cord swelling between T8 and T10, with slight Gd-DTPA enhancement.
  • Because the lesion did not respond to steroid pulse therapy, spinal cord tumor was suspected and biopsy was performed.
  • CONCLUSION: Correct diagnosis of very rare primary intramedullary spinal cord germinoma is important, because these patients can be treated successfully using chemo- and radiotherapy without neurologic deterioration.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / therapy. Spinal Cord / pathology. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Chorionic Gonadotropin, beta Subunit, Human / analysis. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures. Paraparesis / etiology. Radiotherapy. Treatment Outcome. Urination Disorders / etiology

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  • (PMID = 17254883.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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22. Ricci-Vitiani L, Casalbore P, Petrucci G, Lauretti L, Montano N, Larocca LM, Falchetti ML, Lombardi DG, Gerevini VD, Cenciarelli C, D'Alessandris QG, Fernandez E, De Maria R, Maira G, Peschle C, Parati E, Pallini R: Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord. Neurol Res; 2006 Jul;28(5):488-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord.
  • These features make NSCs suitable for spinal cord (SC) reconstruction.
  • However, in vivo experiments have demonstrated that in the injured SC transplanted NSCs either remain undifferentiated or differentiate into the astrocytic phenotype.
  • METHODS: As the first step, we used immunohistochemistry to analyse the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interferon (IFN)-gamma in the normal SC of mice and following traumatic injury.
  • In culture, exposure of proliferating NSCs to a combination of TNF-alpha, IL-1beta and IFN-gamma was per se sufficient to induce the astrocytic differentiation of these cells even in the absence of serum.
  • CONCLUSIONS: In the traumatically injured SC, differentiation of engrafted NSCs is restricted towards the astrocytic lineage because of the inflammatory environment.
  • [MeSH-major] Cytokines / metabolism. Neurons / transplantation. Spinal Cord Injuries / therapy. Stem Cell Transplantation
  • [MeSH-minor] Animals. Astrocytes / cytology. Astrocytes / drug effects. Cell Differentiation / drug effects. Cell Differentiation / physiology. Female. Immunohistochemistry. Interferon-gamma / metabolism. Interferon-gamma / pharmacology. Interleukin-1 / metabolism. Interleukin-1 / pharmacology. Mice. Tumor Necrosis Factor-alpha / metabolism. Tumor Necrosis Factor-alpha / pharmacology

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  • (PMID = 16808877.001).
  • [ISSN] 0161-6412
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-1; 0 / Tumor Necrosis Factor-alpha; 82115-62-6 / Interferon-gamma
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23. O'Brien M, Curtis C, D'Hemecourt P, Proctor M: Case report: a case of persistent back pain and constipation in a 5-year-old boy. Phys Sportsmed; 2009 Apr;37(1):133-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pediatric intramedullary spinal cord tumors are rare and account for 3% to 6% of all central nervous system tumors.
  • We report a case of an intramedullary spinal cord astrocytoma in a 5-year-old boy with nonspecific mid-back pain for 3 months.
  • An urgent magnetic resonance imaging showed an intramedullary tumor in the mid-thoracic cord, confirmed by surgical excision.
  • Associated findings, including nocturnal pain and neurological symptoms may indicate a more serious underlying pathology such as a tumor.
  • [MeSH-major] Astrocytoma / complications. Back Pain / etiology. Constipation / etiology. Spinal Cord Neoplasms / complications

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  • (PMID = 20048499.001).
  • [ISSN] 0091-3847
  • [Journal-full-title] The Physician and sportsmedicine
  • [ISO-abbreviation] Phys Sportsmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Cuadrado-Pereira M, Rodriguez-Saenz J, Andujar-Felix J: Spinal cord high grade astrocytoma. Bol Asoc Med P R; 2007 Jan-Mar;99(1):60-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord high grade astrocytoma.
  • OBJECTIVES: To describe the medical history, psychosocial aspects and the rehabilitation management of a patient with a high-grade astrocytoma of the spinal cord.
  • To review the literature regarding the epidemiology, classification, treatment, prognosis, and outcomes of astrocytomas involving the spinal cord.
  • To discuss issues and controversies in the rehabilitation management of spinal cord high-grade astrocytomas.
  • SETTING: Inpatient Spinal Cord Injury Rehabilitation Unit of Veterans Affair Medical Center; San Juan, Puerto Rico.
  • RESULTS: Aggressive multimodality treatment including acute inpatient interdisciplinary rehabilitation approach provided excellent results exceeding survival time and functional expectations for a patientwith high-grade astrocytoma.
  • (1) the survival time of more than three years, which exceeded the expected survival time of ten months for a patient diagnosed with spinal cord high grade astrocytoma and (2) for the outcomes achieved through an intensive comprehensive acute inpatient interdisci-plinary rehabilitation program which helped the patient achieve previous premorbid functional goals.
  • [MeSH-major] Astrocytoma. Spinal Cord Neoplasms

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  • (PMID = 17616049.001).
  • [ISSN] 0004-4849
  • [Journal-full-title] Boletín de la Asociación Médica de Puerto Rico
  • [ISO-abbreviation] Bol Asoc Med P R
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Puerto Rico
  • [Number-of-references] 18
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25. Kumandaş S, Per H, Gümüş H, Tucer B, Yikilmaz A, Kontaş O, Coşkun A, Kurtsoy A: Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature review. Neurosurg Rev; 2006 Oct;29(4):333-8; discussion 338
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  • [Title] Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature review.
  • Acquired torticollis is not a diagnosis but rather a sign of an underlying disorder.
  • The causes of acquired torticollis include ligamentous, muscular, osseous, ocular, psychiatric, and neurologic disorders and may be a symptom of significant abnormalities of the spinal cord and brain, such as spinal syrinx or central nervous system neoplasia.
  • Torticollis is rarely considered to be an initial clinical presentation of posterior fossa and cervical spinal cord tumors.
  • We report five cases of pediatric tumors with torticollis at the onset: an astrocytoma originating from the medulla oblongata, another presumptive astrocytoma of the spinal cord located between C1 and C6 cervical vertebrae (not operated), an ependymoma located throughout the whole cervical spinal cord extending into the bulbomedullary junction, an astrocytoma originating from the bulbus and extending into the posterior fossa, and another case of a eosinophilic granuloma located extradurally through the anterior and posterior portions of the vertebral bodies from C3 to C7 producing the collapse of the sixth cervical vertebra.
  • All these cases reflect the misinterpretation of this neurological sign and the lack of association with the possibility of spinal or posterior fossa tumor.
  • This delay in the diagnosis of these diseases led to progressive neurological deterioration and to the increase in the tumor size, which made surgical intervention difficult and the prognosis unfavorable.
  • [MeSH-major] Astrocytoma / complications. Eosinophilic Granuloma / complications. Ependymoma / complications. Infratentorial Neoplasms / complications. Spinal Cord Neoplasms / complications. Torticollis / etiology
  • [MeSH-minor] Child. Child, Preschool. Cranial Fossa, Posterior / pathology. Craniotomy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Spinal Cord / pathology. Tomography, X-Ray Computed

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  • (PMID = 16924460.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Plumb J, Cross AK, Surr J, Haddock G, Smith T, Bunning RA, Woodroofe MN: ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. J Neuroimmunol; 2005 Jul;164(1-2):1-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis.
  • Tumour necrosis factor (TNF) is a major immunomodulatory and proinflammatory cytokine implicated in the pathogenesis of multiple sclerosis (MS) and the animal model experimental autoimmune encephalomyelitis (EAE).
  • The distribution and level of ADAM-17 expression within spinal cords of Lewis rats with EAE was investigated.
  • ADAM-17 was associated with endothelial cells in the naïve and pre-disease spinal cords.
  • In peak disease astrocytic and inflammatory cells expressed ADAM-17.
  • [MeSH-major] Encephalomyelitis, Autoimmune, Experimental / metabolism. Gene Expression Regulation / physiology. Metalloendopeptidases / metabolism. Spinal Cord / metabolism. Tissue Inhibitor of Metalloproteinase-3 / metabolism

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  • (PMID = 15878627.001).
  • [ISSN] 0165-5728
  • [Journal-full-title] Journal of neuroimmunology
  • [ISO-abbreviation] J. Neuroimmunol.
  • [Language] eng
  • [Grant] United Kingdom / Multiple Sclerosis Society / / MSS/ 672
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens; 0 / Ectodysplasins; 0 / Glial Fibrillary Acidic Protein; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / Von Willebrand antigen; 0 / von Willebrand Factor; EC 3.4.24.- / ADAM Proteins; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.86 / ADAM17 Protein; EC 3.4.24.86 / Adam17 protein, rat
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27. Rovin RA, Winn R: Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report. J Neurosurg Spine; 2007 May;6(5):447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.
  • The authors report the case of a 28-year-old woman with a high-grade spinal cord astrocytoma.
  • Treatment using surgery, radiation, and temozolomide (TMZ) led to functional recovery and regression of the residual tumor as demonstrated on serial magnetic resonance images.
  • Genetic testing revealed that this tumor did not express the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).
  • This is the first report in the literature correlating MGMT expression with the clinical response of a high-grade spinal cord astrocytoma treated using TMZ.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Astrocytoma / drug therapy. Astrocytoma / metabolism. Dacarbazine / analogs & derivatives. O(6)-Methylguanine-DNA Methyltransferase / metabolism. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / metabolism

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  • (PMID = 17542512.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
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28. Rollins KE, Kleinschmidt-DeMasters BK, Corboy JR, Damek DM, Filley CM: Lymphomatosis cerebri as a cause of white matter dementia. Hum Pathol; 2005 Mar;36(3):282-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microglial and astrocytic reactions, but only subtle myelin pallor, were evident as individual tumor cells permeated the entire brain and spinal cord, albeit with considerable variation in cell density.
  • Individual tumor cells could be identified from the optic nerve to spinal cord, documenting the "whole-brain" nature of the disease.
  • [MeSH-minor] Aged. Aged, 80 and over. Astrocytes / pathology. Biopsy. Brain / pathology. Dementia, Vascular / etiology. Dementia, Vascular / pathology. Fatal Outcome. Female. Humans. Lymphoma, B-Cell / complications. Lymphoma, B-Cell / pathology. Lymphoma, Large B-Cell, Diffuse / complications. Lymphoma, Large B-Cell, Diffuse / pathology. Magnetic Resonance Imaging. Male. Microglia / pathology. Middle Aged. Optic Nerve / pathology. Spinal Cord / pathology

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  • (PMID = 15791573.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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29. Porter A, Lyons MK, Wingerchuk DM, Bosch EP: Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. Clin Neurol Neurosurg; 2006 Dec;108(8):787-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension.
  • Increased intracranial pressure is rarely seen in association with spinal tumors.
  • The spinal MRI showed a low cervical-upper thoracic intramedullary tumor.
  • Open biopsy confirmed a grade 3 fibrillary astrocytoma.
  • The suspected mechanisms of spinal tumors causing increased intracranial pressure are reviewed as well as three other cases of spinal astrocytomas previously reported in the literature that presented with papilledema and increased intracranial pressure without hydrocephalus.
  • This case illustrates that increased intracranial pressure may in exceptional cases of spinal tumors precede the more typical myelopathic presentation by months and mimic idiopathic intracranial hypertension.
  • [MeSH-major] Astrocytoma / diagnosis. Pseudotumor Cerebri / etiology. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Disease Progression. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Neurologic Examination. Papilledema / etiology. Spinal Cord / pathology. Tomography, X-Ray Computed. Vision Disorders / etiology

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  • (PMID = 16298472.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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30. Magilner D: Localized cervical pruritus as the presenting symptom of a spinal cord tumor. Pediatr Emerg Care; 2006 Oct;22(10):746-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Localized cervical pruritus as the presenting symptom of a spinal cord tumor.
  • Intramedullary spinal cord tumors are rare in children.
  • We present an unusual case of a 6-year-old girl who had an intramedullary cervical spinal cord astrocytoma.
  • Pruritus as a symptom of spinal cord pathology is discussed.
  • [MeSH-major] Astrocytoma / diagnosis. Neck Pain / etiology. Pruritus / etiology. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 17047476.001).
  • [ISSN] 1535-1815
  • [Journal-full-title] Pediatric emergency care
  • [ISO-abbreviation] Pediatr Emerg Care
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Milano MT, Johnson MD, Sul J, Mohile NA, Korones DN, Okunieff P, Walter KA: Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. J Neurooncol; 2010 May;98(1):83-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study.
  • To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE).
  • Smaller tumor size also improved survival.
  • Smaller tumor size did not confer a survival benefit.
  • Patients with resected grade 2 spinal cord glioma who did not receive radiotherapy fared well with respect to OS and CSS.
  • For patients with spinal cord glioma, the variables of histology, grade, age and undergoing resection are significant predictors of outcome.
  • [MeSH-major] Glioma / classification. Glioma / epidemiology. SEER Program. Spinal Cord Neoplasms / classification. Spinal Cord Neoplasms / epidemiology

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  • (PMID = 19898743.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Yorgancılar E, Yıldırım M, Gün R, Büyükbayram H, Meriç F: Ganglioglioma in the nasal cavity: a case report. Kulak Burun Bogaz Ihtis Derg; 2010 Sep-Oct;20(5):267-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ganglioglioma is a tumor containing both astrocytic and neuronal components.
  • It may occur any where in the central nervous system and spinal cord but is only encountered rarely.

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  • (PMID = 20815807.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / S100 Proteins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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33. Choi YL, Kim CJ, Matsuo T, Gaetano C, Falconi R, Suh YL, Kim SH, Shin YK, Park SH, Chi JG, Thiele CJ: HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. J Neurooncol; 2005 May;73(1):19-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • HUlip is highly expressed only in the fetal brain and spinal cord, and is undetected in the adult brain.
  • Ten human brains at different developmental stages and 118 cases of nervous system tumor tissues were examined by immunohistochemistry.
  • Twelve related tumor cell lines were also analyzed by northern blotting and immunoblotting.
  • Among tumors, hUlip expression was easily detected in tumor cells undergoing neuronal differentiation such as ganglioneuroblastomas and ganglioneuromas.
  • Furthermore, hUlip immunoreactivity was also found in various brain tumors showing neuronal differentiation: central neurocytomas (6 of 6 cases were positive), medulloblastomas (5/11), atypical teratoid rhabdoid tumor (1/1) and gangliogliomas (4/7).
  • Some astrocytic tumors also showed weak positivity: astrocytomas (1 of 5 cases), anaplastic astrocytomas (2/5), and glioblastomas (3/11).
  • [MeSH-minor] Astrocytes / cytology. Astrocytes / metabolism. Cell Differentiation / genetics. Cell Differentiation / physiology. Cell Line, Tumor. Female. Gestational Age. Humans. Immunohistochemistry. Male. Neuroblastoma / genetics. Neuroblastoma / metabolism. Neurons / cytology. Neurons / metabolism

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  • (PMID = 15933812.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DPYSL3 protein, human; 0 / Muscle Proteins
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34. Chio CC, Lin JW, Chang MW, Wang CC, Kuo JR, Yang CZ, Chang CP: Therapeutic evaluation of etanercept in a model of traumatic brain injury. J Neurochem; 2010 Nov;115(4):921-9
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  • Antagonism of tumor necrosis factor-alpha with etanercept has proved to be effective in the treatment of spinal cord injury and centrally endotoxin-induced brain injury.
  • TBI-induced neuronal apoptosis (e.g., increased numbers of terminal deoxynucleotidyl transferase αUTP nick-end labeling and neuronal-specific nuclear protein double-positive cells), glial apoptosis (e.g., increased numbers of terminal deoxynucleotidyl transferase αUTP nick-end labeling and glial fibrillary acidic protein double-positive cells), astrocytic (e.g., increased numbers of glial fibrillary acidic protein positive cells) and microglial (e.g., increased numbers of ionized calcium-binding adapter molecule 1-positive cells) activation and activated inflammation (e.g., increased levels of tumor necrosis factor-alpha, interleukin-1β and interleukin-6) were all significantly reduced by etanercept treatment.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Brain Injuries / drug therapy. Disease Models, Animal. Immunoglobulin G / therapeutic use. Receptors, Tumor Necrosis Factor / therapeutic use
  • [MeSH-minor] Animals. Drug Evaluation, Preclinical / methods. Etanercept. Hippocampus / metabolism. Hippocampus / pathology. Male. Random Allocation. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / antagonists & inhibitors. Tumor Necrosis Factor-alpha / metabolism

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  • [Copyright] © 2010 The Authors. Journal of Neurochemistry © 2010 International Society for Neurochemistry.
  • (PMID = 20796174.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factor-alpha; OP401G7OJC / Etanercept
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35. Sharma S, Free A, Mei Y, Peiper SC, Wang Z, Cowell JK: Distinct molecular signatures in pediatric infratentorial glioblastomas defined by aCGH. Exp Mol Pathol; 2010 Oct;89(2):169-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Glioblastomas (GBM) are rare in children, but reportedly have more varied outcome which suggests differences in tumor etiology compared to typical GBM of adults.
  • Two of these tumors occurred in the brainstem and one in the spinal cord.
  • While histologically typical, one brainstem tumor showed mainly pleomorphic astrocytic cells, whereas the other brainstem and spinal tumors showed a GFAP positive small cell component.
  • The spinal GBM showed a relatively stable karyotype with a unique loss of Chr19;32848902-qter.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20621092.001).
  • [ISSN] 1096-0945
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Marchan EM, Sekula RF Jr, Jannetta PJ, Quigley MR: Long-term survival enhanced by cordectomy in a patient with a spinal glioblastoma multiforme and paraplegia. Case report. J Neurosurg Spine; 2007 Dec;7(6):656-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival enhanced by cordectomy in a patient with a spinal glioblastoma multiforme and paraplegia. Case report.
  • Spinal glioblastomas multiforme (GBMs) are rare lesions of the central nervous system with a prognosis as poor as that of their intracranial counterpart.
  • The authors present a case of a 50-year-old man with a GBM of the spinal cord treated with surgical removal of the mass and cordectomy after the onset of paraplegia.
  • Although intracranial dissemination of spinal GBMs has been reported, this case illustrates the longest reported interval between the occurrence of a spinal GBM and its intracranial dissemination.
  • Thus, cordectomy should be considered as a reasonable alternative in patients with complete loss of neurological function at and below the level where they harbor a malignant spinal cord astrocytoma.
  • [MeSH-major] Glioblastoma / complications. Glioblastoma / surgery. Neurosurgical Procedures. Paraplegia / etiology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Antiviral Agents / therapeutic use. Cerebellar Neoplasms / secondary. Fatal Outcome. Hepatitis C / complications. Hepatitis C / drug therapy. Humans. Interferon-alpha / therapeutic use. Magnetic Resonance Imaging. Male. Middle Aged. Polyethylene Glycols. Recombinant Proteins. Spinal Cord / surgery. Survival Analysis

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  • (PMID = 18074692.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 99210-65-8 / interferon alfa-2b
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37. Giraud SN, Caron CM, Pham-Dinh D, Kitabgi P, Nicot AB: Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes. Proc Natl Acad Sci U S A; 2010 May 4;107(18):8416-21
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  • Using mouse experimental allergic encephalomyelitis (EAE) as a model of chronic neuroinflammation, we report that implants reproducing pregnancy levels of 17beta-estradiol (E2) alleviate ongoing disease and decrease astrocytic production of CCL2, a proinflammatory chemokine that drives the local recruitment of inflammatory myeloid cells.
  • Immunohistochemistry and confocal imaging reveal that, in spinal cord white matter EAE lesions, reactive astrocytes express estrogen receptor (ER)alpha (and to a lesser extent ERbeta) with a preferential nuclear localization, whereas other cells including infiltrated leukocytes express ERs only in their membranes or cytosol.
  • These data uncover reactive astrocytes as an important target for nuclear ERalpha inhibitory action on chemokine expression and suggest that targeting astrocytic nuclear NFkappaB activation with estrogen receptor alpha modulators may improve therapies of chronic neurodegenerative disorders involving astroglial neuroinflammation.
  • [MeSH-minor] Active Transport, Cell Nucleus. Animals. Cells, Cultured. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / metabolism. Female. Leukocytes / metabolism. Mice. Mice, Inbred C57BL. Rats. Spinal Cord / metabolism. Transcription, Genetic. Tumor Necrosis Factor-alpha / metabolism

  • Hazardous Substances Data Bank. ESTRADIOL .
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
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  • (PMID = 20404154.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ccl2 protein, mouse; 0 / Chemokine CCL2; 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / NF-kappa B; 0 / Tumor Necrosis Factor-alpha; 4TI98Z838E / Estradiol
  • [Other-IDs] NLM/ PMC2889572
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38. Zhou D, Zhang Y, Liu H, Luo S, Luo L, Dai K: Epidemiology of nervous system tumors in children: a survey of 1,485 cases in Beijing Tiantan Hospital from 2001 to 2005. Pediatr Neurosurg; 2008;44(2):97-103

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: During a 5-year period, from January 2001 to December 2005, 1,485 primary brain and spinal tumors in children up to 17 years of age were diagnosed histopathologically according to the World Health Organization 2000 nervous system tumor classification.
  • The sex predilection, tumor location, and histological grade in relation to age were investigated, and the epidemiological characteristics of the 5 most common brain tumors are discussed.
  • RESULT: Of the 1,485 cases evaluated, brain and spinal tumors comprised 92.3% (1,371) and 7.7% (114), respectively, with a predominance of low-grade tumors (65.1 and 78.9% for brain and spinal cord, respectively).
  • The 5 most common brain tumors were astrocytic tumors (30.5%), craniopharyngiomas (18.4%), medulloblastomas (14.6%), germ cell tumors (GCTs, 7.9%) and ependymal tumors (5.6%).
  • The most common types of spinal tumors were ependymal tumors (19.3%), neurilemmomas (16.7%) and astrocytomas (14.9%).

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  • (PMID = 18230922.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
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39. Saad A, Tuli S, Ali EN, Houtchens M, Delalle I, Kesari S: Pilocytic astrocytoma of the spinal cord in an adult. J Neurooncol; 2008 Jun;88(2):189-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilocytic astrocytoma of the spinal cord in an adult.
  • [MeSH-major] Astrocytoma. Spinal Cord Neoplasms

  • Genetic Alliance. consumer health - Pilocytic astrocytoma.
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  • (PMID = 18340405.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein
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40. Cathebras P, Koenig M: Spinal cord astrocytoma mistaken for conversion disorder. Psychosomatics; 2005 Mar-Apr;46(2):187-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal cord astrocytoma mistaken for conversion disorder.
  • [MeSH-major] Astrocytoma / diagnosis. Conversion Disorder / diagnosis. Diagnostic Errors. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 15774957.001).
  • [ISSN] 0033-3182
  • [Journal-full-title] Psychosomatics
  • [ISO-abbreviation] Psychosomatics
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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