[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 2723
1. Azzalin A, Del Vecchio I, Chiarelli LR, Valentini G, Comincini S, Ferretti L: Absence of interaction between doppel and GFAP, Grb2, PrPc proteins in human tumor astrocytic cells. Anticancer Res; 2005 Nov-Dec;25(6B):4369-74
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of interaction between doppel and GFAP, Grb2, PrPc proteins in human tumor astrocytic cells.
  • Recently, Dpl was shown to be aberrantly expressed in astrocytic tumor specimens and in astrocytoma-derived cell lines, showing a peculiar cytoplasmic localization.
  • In particular, whether the tumor astrocytic environment is suitable for doppel interaction with GFAP and Grb2 proteins, as well as with the PrPC protein itself was investigated.
  • Our findings provided evidence that, in our astrocytoma cell-based model, Dpl does not share with PrP(C) the ability to interact with GFAP and Grb2.
  • CONCLUSION: Identifying Dpl ligands may provide new insights into the involvement of Dpl in astrocytoma tumor progression.
  • [MeSH-major] Astrocytoma / metabolism. GRB2 Adaptor Protein / metabolism. Glial Fibrillary Acidic Protein / metabolism. PrPC Proteins / metabolism. Prions / metabolism

  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16309242.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / GRB2 Adaptor Protein; 0 / GRB2 protein, human; 0 / Glial Fibrillary Acidic Protein; 0 / PRND protein, human; 0 / PrPC Proteins; 0 / Prions
  •  go-up   go-down


2. Sekula RF Jr, Marchan EM, Quigley MR, Frederickson AM, Pu C: A case of an elderly adult presenting with obstructive hydrocephalus secondary to a rare hemorrhagic suprasellar pilocytic astrocytoma. Clin Neuropathol; 2008 Nov-Dec;27(6):396-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of an elderly adult presenting with obstructive hydrocephalus secondary to a rare hemorrhagic suprasellar pilocytic astrocytoma.
  • Urgent surgery was performed and final pathology eventuated a pilocytic astrocytoma.
  • Although rare cases of suprasellar pilocytic astrocytoma in children and adults have been reported, we report an interesting case of a hemorrhagic suprasellar pilocytic astrocytoma in an elderly adult (without prior anticoagulant use) causing impending brain herniation secondary to obstructive hydrocephalus.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Cerebral Hemorrhage / etiology. Hydrocephalus / etiology


3. Zhao YC, Li NY, Zhou XJ: [Updates on clinicopathologic researches of pilocytic astrocytoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Dec;36(12):846-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Updates on clinicopathologic researches of pilocytic astrocytoma].
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / pathology

  • Genetic Alliance. consumer health - Pilocytic astrocytoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18346360.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 25
  •  go-up   go-down


Advertisement
4. Hu W, Shen F, Chen G, Shen G, Liu W, Zhou J: Possible involvement of brain tumour stem cells in the emergence of a fast-growing malignant meningioma after surgical resection and radiotherapy of high-grade astrocytoma: case report and preliminary laboratory investigation. J Int Med Res; 2009 Jan-Feb;37(1):240-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Possible involvement of brain tumour stem cells in the emergence of a fast-growing malignant meningioma after surgical resection and radiotherapy of high-grade astrocytoma: case report and preliminary laboratory investigation.
  • The case of a 62-year old man diagnosed with radiation-induced meningioma (RIM) after treatment for astrocytoma with an unusually short latency period of 7 months is reported.
  • Gross total resection was performed and the tumour was confirmed to be an astrocytoma.
  • A rare fraction of brain tumour stem cells (BTSC) was isolated from the primary astrocytoma using a serum-free culture system, suggesting that BTSC may have been involved in the rapid emergence of RIM after resection and radiation of the primary astrocytoma.
  • [MeSH-major] Astrocytoma / radiotherapy. Astrocytoma / surgery. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Meningioma / pathology. Meningioma / secondary. Neoplastic Stem Cells / pathology
  • [MeSH-minor] Combined Modality Therapy. Disease Progression. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Time Factors. Tumor Cells, Cultured

  • Genetic Alliance. consumer health - Meningioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19215696.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  •  go-up   go-down


5. Huang CX, Liu YS, Hou YH: [Detection and clinical significance of urinary epidermal growth factor in brain tumor patients]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2006 Apr;31(2):268-70
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Detection and clinical significance of urinary epidermal growth factor in brain tumor patients].
  • METHODS: The levels of EGF in urine samples collected from 20 patients (9 low grade astrocytomas, 6 anaplastic astrocytomas, and 5 meningiomas) and 5 healthy individuals were determined.
  • RESULTS: Preoperative urinary EGF levels of astrocytoma patients were statistically higher than those of meningioma patients and the controls (P < 0.01).
  • Preoperative urinary EGF levels showed a positive correlation with the degree of malignance in the astrocytoma patients (P < 0.05).
  • A significant decrease of the postoperative levels of EGF was observed in the astrocytoma patients who underwent gross total resection (P < 0.01).
  • CONCLUSION: The urinary EGF levels of astrocytoma patients correlate with the WHO grade of malignance and significantly decrease after gross total removal.
  • Urinary EGF may be of practical value in diagnosing and evaluating the surgical efficacy of astrocytomas.
  • [MeSH-major] Astrocytoma / urine. Biomarkers, Tumor / urine. Brain Neoplasms / urine. Epidermal Growth Factor / urine

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16706130.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 62229-50-9 / Epidermal Growth Factor
  •  go-up   go-down


6. Marsh J, Mukherjee P, Seyfried TN: Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma. Clin Cancer Res; 2008 Dec 1;14(23):7751-62
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma.
  • PURPOSE: Malignant astrocytomas exhibit constitutive Akt phosphorylation due to reduced phosphatase and tensin homologue (PTEN) tumor suppressor expression or to increased growth factor receptor tyrosine kinase activation.
  • Many astrocytomas are also tuberous sclerosis complex 2 (TSC2) protein deficient and exhibit constitutive mammalian target of rapamycin (mTOR) activity.
  • Astrocytomas harboring PTEN/Akt/TSC2 pathway mutations are dependent on glycolysis to satisfy their bioenergetic requirements.
  • Therapies that disrupt energy homeostasis can potentially manage astrocytoma growth and progression.
  • Although dietary restriction (DR) reduces glycolysis and manages early-stage astrocytoma growth, no prior studies have identified the mechanisms involved or determined if DR can also manage late-stage tumor growth.
  • EXPERIMENTAL DESIGN: The effects of a late-onset intermittent DR feeding paradigm were examined in adult C57BL/6J mice bearing the syngeneic CT-2A malignant astrocytoma grown orthotopically or subcutaneously.
  • DR initiated 10 to 14 days after tumor implantation (late onset) reduced CT-2A growth, delayed malignant progression, and significantly extended survival.
  • CONCLUSIONS: Our findings indicate that IGF-I/Akt signaling is associated with the antiapoptotic and glycolytic phenotype of the CT-2A astrocytoma and that DR targets this pathway.
  • Our findings highlight the efficacy of late-onset DR in managing astrocytoma growth and suggest that DR may be an effective broad-spectrum inhibitor of Akt signaling in PTEN/TSC2-deficient astrocytomas.
  • [MeSH-major] Astrocytoma / diet therapy. Brain Neoplasms / diet therapy. PTEN Phosphohydrolase / deficiency. Proto-Oncogene Proteins c-akt / metabolism. Tumor Suppressor Proteins / deficiency

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19047102.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA102135; United States / NINDS NIH HHS / NS / NS 055195
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.67 / PTEN Phosphohydrolase
  •  go-up   go-down


7. Parhar P, Ezer R, Shao Y, Allen JC, Miller DC, Newcomb EW: Possible association of p53 codon 72 polymorphism with susceptibility to adult and pediatric high-grade astrocytomas. Brain Res Mol Brain Res; 2005 Jun 13;137(1-2):98-103
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Possible association of p53 codon 72 polymorphism with susceptibility to adult and pediatric high-grade astrocytomas.
  • Polymorphisms in codon 72 of the p53 tumor suppressor gene have been associated with susceptibility to human cancer.
  • In this study, we scored 135 brain tumor samples (92 adult and 43 pediatric cases consisting of 64 high-grade astrocytomas and 71 non-astrocytomas) for the P53 Arg72Pro polymorphisms.
  • (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002).
  • Our results suggest a possible association between P53 Arg72Pro polymorphisms and susceptibility to brain tumors, particularly high-grade astrocytomas.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Codon / genetics. Genetic Predisposition to Disease / genetics. Polymorphism, Genetic / genetics. Tumor Suppressor Protein p53 / genetics

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15950766.001).
  • [ISSN] 0169-328X
  • [Journal-full-title] Brain research. Molecular brain research
  • [ISO-abbreviation] Brain Res. Mol. Brain Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5 U10 CA13539-29; United States / NCI NIH HHS / CA / CA90290
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Codon; 0 / Tumor Suppressor Protein p53
  •  go-up   go-down


8. Sanders RP, Kocak M, Burger PC, Merchant TE, Gajjar A, Broniscer A: High-grade astrocytoma in very young children. Pediatr Blood Cancer; 2007 Dec;49(7):888-93
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-grade astrocytoma in very young children.
  • BACKGROUND: High-grade astrocytomas are rare in young children, but have been reported to have a better prognosis than similar tumors in older patients.
  • PROCEDURE: We retrospectively reviewed the clinical characteristics, survival, and long-term sequelae for patients younger than 3 years old with high-grade astrocytoma, treated at a single institution between 1984 and 2005.
  • Histology included anaplastic astrocytoma (n = 9), glioblastoma multiforme (n = 5), and malignant glioma (n = 2).
  • Six patients received scheduled irradiation and six were irradiated at the time of disease progression.
  • CONCLUSIONS: Young children with high-grade astrocytoma have better long-term overall survival than older patients, but recurrence is common, and most children require irradiation.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / therapy. Brain Neoplasms / therapy
  • [MeSH-minor] Age Factors. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Infant. Male. Neuropsychological Tests. Predictive Value of Tests. Prognosis. Recurrence. Retrospective Studies. Survival Rate. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2007 Wiley-Liss, Inc
  • [CommentIn] Pediatr Blood Cancer. 2007 Dec;49(7):879-80 [17941062.001]
  • (PMID = 17554787.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


9. Allerstorfer S, Sonvilla G, Fischer H, Spiegl-Kreinecker S, Gauglhofer C, Setinek U, Czech T, Marosi C, Buchroithner J, Pichler J, Silye R, Mohr T, Holzmann K, Grasl-Kraupp B, Marian B, Grusch M, Fischer J, Micksche M, Berger W: FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities. Oncogene; 2008 Jul 10;27(30):4180-90
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we report simultaneous overexpression of FGF5 and its predominant high-affinity receptor (FGFR1 IIIc) in astrocytic brain tumour specimens (N=49) and cell cultures (N=49).
  • In summary, we demonstrate for the first time that FGF5 contributes to the malignant progression of human astrocytic brain tumours by both autocrine and paracrine effects.
  • [MeSH-minor] Cell Death / drug effects. Cell Movement / drug effects. Cell Proliferation / drug effects. Culture Media, Conditioned / pharmacology. Disease Progression. Genes, Dominant / physiology. Humans. Mutant Proteins / genetics. Mutant Proteins / physiology. Neovascularization, Pathologic / chemically induced. Neovascularization, Pathologic / genetics. Recombinant Proteins / pharmacology. Transfection. Tumor Cells, Cultured

  • Genetic Alliance. consumer health - Glioblastoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Brain Res Mol Brain Res. 1996 May;38(1):161-5 [8737680.001]
  • [Cites] J Biol Chem. 1996 Jun 21;271(25):15292-7 [8663044.001]
  • [Cites] Vet Pathol. 1997 May;34(3):171-9 [9163872.001]
  • [Cites] Oncogene. 1997 Sep 18;15(12):1417-24 [9333017.001]
  • [Cites] Prog Nucleic Acid Res Mol Biol. 1998;59:135-76 [9427842.001]
  • [Cites] Cancer Res. 1998 Jan 15;58(2):352-61 [9443417.001]
  • [Cites] Surg Neurol. 1998 Feb;49(2):189-95; discussion 196 [9457270.001]
  • [Cites] Biochem Cell Biol. 1997;75(6):669-85 [9599656.001]
  • [Cites] J Pharmacol Exp Ther. 1998 Jul;286(1):569-77 [9655904.001]
  • [Cites] Neurosurgery. 1998 Aug;43(2):337-46 [9696088.001]
  • [Cites] J Biol Chem. 1998 Oct 30;273(44):29262-71 [9786939.001]
  • [Cites] Cancer Res. 1998 Dec 1;58(23):5285-90 [9850049.001]
  • [Cites] J Invest Dermatol. 1998 Dec;111(6):963-72 [9856803.001]
  • [Cites] Int J Cancer. 1999 Oct 29;83(3):415-23 [10495436.001]
  • [Cites] J Cancer Res Clin Oncol. 2005 Jun;131(6):355-63 [15856298.001]
  • [Cites] Cytokine Growth Factor Rev. 2005 Apr;16(2):139-49 [15863030.001]
  • [Cites] Cytokine Growth Factor Rev. 2005 Apr;16(2):179-86 [15863033.001]
  • [Cites] Growth Factors. 2005 Jun;23(2):87-95 [16019430.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11011-6 [16046538.001]
  • [Cites] Biochem Pharmacol. 2006 Feb 14;71(4):426-40 [16343446.001]
  • [Cites] J Cell Sci. 2006 Feb 1;119(Pt 3):459-69 [16418217.001]
  • [Cites] Cancer Res. 2006 Apr 1;66(7):3584-92 [16585183.001]
  • [Cites] J Neurooncol. 2006 Jul;78(3):281-93 [16554966.001]
  • [Cites] Mol Cancer Res. 2006 Dec;4(12):927-34 [17189383.001]
  • [Cites] Br J Cancer. 2007 Mar 26;96(6):960-9 [17342095.001]
  • [Cites] Blood. 2007 Dec 1;110(12):4055-63 [17720881.001]
  • [Cites] J Neurosci. 2003 Jul 23;23(16):6404-12 [12878680.001]
  • [Cites] Cell Tissue Res. 2003 Aug;313(2):139-57 [12845521.001]
  • [Cites] J Clin Invest. 1973 Nov;52(11):2745-56 [4355998.001]
  • [Cites] Mol Cell Biol. 1988 Aug;8(8):3487-95 [3211147.001]
  • [Cites] Proc Natl Acad Sci U S A. 1990 Oct;87(20):8022-6 [1700424.001]
  • [Cites] Mol Cell Biol. 1991 Apr;11(4):1840-5 [2005884.001]
  • [Cites] Development. 1991 Jun;112(2):397-406 [1794310.001]
  • [Cites] J Invest Dermatol. 2000 Mar;114(3):456-63 [10692103.001]
  • [Cites] Glia. 2000 May;30(3):231-41 [10756073.001]
  • [Cites] Nat Cell Biol. 2001 Jul;3(7):650-7 [11433297.001]
  • [Cites] Cancer Res. 2001 Jul 15;61(14):5511-6 [11454700.001]
  • [Cites] J Cell Sci. 2002 Jan 15;115(Pt 2):329-39 [11839785.001]
  • [Cites] Int J Pancreatol. 2001;29(2):85-92 [11876253.001]
  • [Cites] Neurol Res. 2002 Apr;24(3):244-8 [11958417.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Feb;88(2):773-80 [12574212.001]
  • [Cites] Int J Cancer. 1993 Jan 21;53(2):209-14 [8381111.001]
  • [Cites] Neuron. 1993 Mar;10(3):369-77 [8461132.001]
  • [Cites] Brain Res. 1993 Mar 19;606(1):79-86 [8462006.001]
  • [Cites] Eur J Neurosci. 1994 Feb 1;6(2):244-52 [8167846.001]
  • [Cites] Cancer Res. 1994 May 15;54(10):2794-9 [8168112.001]
  • [Cites] Cell. 1994 Sep 23;78(6):1017-25 [7923352.001]
  • [Cites] J Neurooncol. 1994;18(3):207-16 [7964981.001]
  • [Cites] Oncogene. 1997 Jan 16;14(2):171-83 [9010219.001]
  • (PMID = 18362893.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / P 19920
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / FGF5 protein, human; 0 / Mutant Proteins; 0 / Recombinant Proteins; 129653-64-1 / Fibroblast Growth Factor 5
  • [Other-IDs] NLM/ PMC2879862; NLM/ UKMS30927
  •  go-up   go-down


10. Essig M, Rohrer M, Giesel F, Tüttenberg J, Weber MA, Michaely H, Gerigk L, Voth M: Human brain tumor imaging with a protein-binding MR contrast agent: initial experience. Eur Radiol; 2010 Jan;20(1):218-26
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human brain tumor imaging with a protein-binding MR contrast agent: initial experience.
  • In one nonenhancing low grade astrocytoma an enhancing nodule became visible only 5 h after gadofosvesest injection.
  • As shown in this initial report, contrast-enhanced intracranial tumor imaging is possible with the protein-binding blood pool agent gadofosveset.
  • The agent gives a significant tumor contrast in early postcontrast imaging comparable with conventional agents.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • Hazardous Substances Data Bank. GADOLINIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Curr Rheumatol Rep. 2006 Apr;8(2):151-7 [16569375.001]
  • [Cites] Radiology. 2005 Sep;236(3):825-33 [16020554.001]
  • [Cites] Nephrol Dial Transplant. 2006 Apr;21(4):1104-8 [16431890.001]
  • [Cites] Semin Oncol. 1994 Apr;21(2):162-71 [8153662.001]
  • [Cites] Radiology. 2006 Dec;241(3):861-72 [17032914.001]
  • [Cites] N Engl J Med. 1991 May 30;324(22):1555-64 [2027359.001]
  • [Cites] Neurosurgery. 2004 Jan;54(1):131-40; discussion 141-2 [14683550.001]
  • [Cites] Curr Opin Investig Drugs. 2004 Sep;5(9):967-76 [15503653.001]
  • [Cites] Top Magn Reson Imaging. 2006 Apr;17(2):89-106 [17198225.001]
  • [Cites] Radiology. 1984 Jul;152(1):71-7 [6729138.001]
  • [Cites] Magn Reson Med. 2003 Mar;49(3):586-90 [12594765.001]
  • [Cites] J Comput Assist Tomogr. 1988 Mar-Apr;12(2):266-74 [3351041.001]
  • [Cites] Invest Radiol. 2005 Nov;40(11):715-24 [16230904.001]
  • [Cites] Invest Radiol. 2001 May;36(5):266-75 [11323514.001]
  • [Cites] Radiology. 2006 Aug;240(2):389-400 [16801373.001]
  • [Cites] Radiology. 1989 Oct;173(1):231-8 [2781014.001]
  • [Cites] Invest Radiol. 2008 Dec;43(12):817-28 [19002053.001]
  • [Cites] Radiology. 2003 Dec;229(3):811-20 [14593194.001]
  • [Cites] Invest Radiol. 2001 Feb;36(2):123-30 [11224761.001]
  • [Cites] AJNR Am J Neuroradiol. 1990 Jul-Aug;11(4):785-91 [2114769.001]
  • [Cites] Magn Reson Imaging Clin N Am. 2008 Nov;16(4):551-60, vii [18926421.001]
  • [Cites] Eur Radiol. 2006 Feb;16 Suppl 2:B15-23 [16802439.001]
  • [Cites] Invest Radiol. 2006 Mar;41(3):229-43 [16481905.001]
  • [Cites] Neuroradiology. 1988;30(2):145-54 [3386808.001]
  • [Cites] Radiology. 1998 May;207(2):539-44 [9577507.001]
  • [Cites] Cancer Treat Rev. 2000 Dec;26(6):449-62 [11139374.001]
  • [Cites] Eur Radiol. 2004 May;14 Suppl 5:M12-8 [15457995.001]
  • (PMID = 19672603.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Blood Proteins; 0 / Contrast Media; 0 / Organometallic Compounds; AU0V1LM3JT / Gadolinium; XM33Q67UVH / gadofosveset trisodium
  •  go-up   go-down


11. Wolff JE, Berrak S, Koontz Webb SE, Zhang M: Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients. J Neurooncol; 2008 May;88(1):57-63
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.
  • Even though past studies have suggested efficacy of nitrosourea drugs in patients with high-grade glioma and temozolomide has recently been shown significantly to be beneficial, no conclusive comparisons between these agents have been published.
  • We performed a survival gain analysis of 364 studies describing 24,193 patients with high-grade glioma treated in 504 cohorts, and compared the effects of drugs.
  • The most frequent diagnoses were glioblastoma multiforme (GBM) (72%) and anaplastic astrocytoma (22%).
  • This information allowed the calculation of a predicted mOS for each cohort based on their prognostic factors independent of treatment.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Glioma / drug therapy. Nitrosourea Compounds / therapeutic use
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / drug therapy. Astrocytoma / pathology. Carmustine / adverse effects. Carmustine / therapeutic use. Clinical Trials as Topic. Cohort Studies. Data Interpretation, Statistical. Databases, Factual. Female. Glioblastoma / drug therapy. Glioblastoma / pathology. Humans. Lomustine / adverse effects. Lomustine / therapeutic use. Male. Nimustine / adverse effects. Nimustine / therapeutic use. Reproducibility of Results. Selection Bias. Survival Analysis. Treatment Outcome

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • Hazardous Substances Data Bank. LOMUSTINE .
  • Hazardous Substances Data Bank. Carmustine .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Int J Cancer. 1996 Feb 8;65(4):506-12 [8621235.001]
  • [Cites] J Neurooncol. 2006 Sep;79(3):281-7 [16598416.001]
  • [Cites] Neuro Oncol. 2006 Jan;8(1):12-26 [16443944.001]
  • [Cites] Eur J Cancer. 1991;27(5):630-8 [1828975.001]
  • [Cites] Stat Med. 2002 Jun 15;21(11):1559-73 [12111920.001]
  • [Cites] J Clin Epidemiol. 2006 Oct;59(10):1102-9 [16980151.001]
  • [Cites] Surg Neurol. 2005 Feb;63(2):162-9; discussion 169 [15680662.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1990 Feb;18(2):321-4 [2154418.001]
  • [Cites] Cancer Res. 1965 Dec;25(11):1876-81 [5858571.001]
  • [Cites] Acta Neurochir (Wien). 2006 Mar;148(3):269-75; discussion 275 [16482400.001]
  • [Cites] Neurol Med Chir (Tokyo). 2001 Mar;41(3):115-9; discussion 119-20 [11372553.001]
  • [Cites] Cancer. 2005 Aug 15;104(4):825-32 [15981281.001]
  • [Cites] J Cancer Res Clin Oncol. 1999 Aug-Sep;125(8-9):481-6 [10480340.001]
  • [Cites] Anticancer Res. 2005 Sep-Oct;25(5):3585-90 [16101184.001]
  • [Cites] AJNR Am J Neuroradiol. 2005 Nov-Dec;26(10):2466-74 [16286386.001]
  • [Cites] J Clin Oncol. 2003 Apr 15;21(8):1485-91 [12697871.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10 ):987-96 [15758009.001]
  • (PMID = 18253699.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 16672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Nitrosourea Compounds; 0S726V972K / Nimustine; 7BRF0Z81KG / Lomustine; U68WG3173Y / Carmustine
  •  go-up   go-down


12. Mobasheri MB, Jahanzad I, Mohagheghi MA, Aarabi M, Farzan S, Modarressi MH: Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features. Cancer Detect Prev; 2007;31(4):296-302
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: In this study expression of TSGA10 and SYCP3 were investigated in different cancers (156 tumor samples) using RT-PCR.
  • But, SYCP3 transcripts were found in four tumor samples (moderately differentiated gemistocytic astrocytoma, pituitary adenoma, glioma and an ovarian tumor).
  • [MeSH-major] Biomarkers, Tumor / genetics. Gene Expression. Neoplasms / genetics. Neoplasms / pathology. Nuclear Proteins / genetics. Proteins / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17920210.001).
  • [ISSN] 0361-090X
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Proteins; 0 / SYCP3 protein, human; 0 / TSGA10 protein, human
  •  go-up   go-down


13. Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K: Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells. J Neurochem; 2007 Oct;103(1):259-75
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The neurotrophin receptor tropomyosin-related kinase A (TrkA) and its ligand nerve growth factor (NGF) are expressed in astrocytomas, and an inverse association of TrkA expression with malignancy grade was described.
  • [MeSH-minor] Cell Line, Tumor. Enzyme Activation / drug effects. Extracellular Signal-Regulated MAP Kinases / metabolism. Gene Transfer Techniques. Humans. JNK Mitogen-Activated Protein Kinases / metabolism. Nerve Growth Factor / pharmacology. Vacuoles / ultrastructure


14. Zhou B, Phan V, Liu X, Juhasz A, Chu PG, Yen Y: Production of a monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry study of human cancer tissues. Hybridoma (Larchmt); 2006 Oct;25(5):264-70
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Production of a monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry study of human cancer tissues.
  • We report production of a monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry (IHC) staining of human cancer tissues available in paraffin block.
  • No staining was identified on astrocytoma, mesothelioma, or myeloma.
  • [MeSH-minor] Animals. Antigens, Neoplasm / immunology. Breast Neoplasms / metabolism. Carcinoma / metabolism. Humans. Hybridomas / metabolism. Mice. Mice, Inbred BALB C. Oropharyngeal Neoplasms / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Ribonucleotide Reductases / immunology

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17044781.001).
  • [ISSN] 1554-0014
  • [Journal-full-title] Hybridoma (2005)
  • [ISO-abbreviation] Hybridoma (Larchmt)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; EC 1.17.4.- / Ribonucleotide Reductases; EC 1.17.4.- / ribonucleotide reductase M2; EC 1.17.4.1 / Ribonucleoside Diphosphate Reductase
  •  go-up   go-down


15. Tamiya T, Takao S, Ichikawa T, Chayama K, Date I: Successful chemotherapy for congenital malignant gliomas: a report of two cases. Pediatr Neurosurg; 2006;42(4):240-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful chemotherapy for congenital malignant gliomas: a report of two cases.
  • We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy.
  • A T(1)-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe.
  • The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma.
  • The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank.
  • The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide).
  • The tumor has not recurred in more than 8.5 years.
  • The T(1)-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor.
  • The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma.
  • The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years.
  • Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Astrocytoma / therapy. Brain Neoplasms / therapy. Ganglioglioma / therapy

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • Hazardous Substances Data Bank. ETOPOSIDE .
  • Hazardous Substances Data Bank. CARBOPLATIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16714866.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Nitrosourea Compounds; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; RYH2T97J77 / ranimustine
  •  go-up   go-down


16. Buckle MJ, Ellis RW, Bone M, Lockman H: Neurologically presenting Whipple disease: case report and review of the literature. J Clin Pathol; 2008 Oct;61(10):1140-1
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurologically presenting Whipple disease: case report and review of the literature.
  • A previously healthy male with subacute onset right leg weakness was suspected to have an astrocytoma as imaging showed a lesion.
  • Subsequent biopsy showed the presence of foamy macrophages containing periodic acid-Schiff staining granules, suggesting Whipple disease as a possible diagnosis.
  • [MeSH-major] Spinal Diseases / pathology. Whipple Disease / pathology

  • Genetic Alliance. consumer health - Whipple disease.
  • MedlinePlus Health Information. consumer health - Spine Injuries and Disorders.
  • Hazardous Substances Data Bank. TRIMETHOPRIM/SULFAMETHOXAZOLE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18381382.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 75J73V1629 / Ceftriaxone; 8064-90-2 / Trimethoprim, Sulfamethoxazole Drug Combination
  • [Number-of-references] 5
  •  go-up   go-down


17. Regan EM, Uney JB, Dick AD, Zhang Y, Nunez-Yanez J, McGeehan JP, Claeyssens F, Kelly S: Differential patterning of neuronal, glial and neural progenitor cells on phosphorus-doped and UV irradiated diamond-like carbon. Biomaterials; 2010 Jan;31(2):207-15
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the present study we complement and extend these findings by exploring patterning of dorsal root ganglion (DRG) explants, human neural progenitor cells (hNPC) and U-87 astroglioma cells on P:DLC.

  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. PHOSPHORUS, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19833386.001).
  • [ISSN] 1878-5905
  • [Journal-full-title] Biomaterials
  • [ISO-abbreviation] Biomaterials
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 27YLU75U4W / Phosphorus; 7782-40-3 / Diamond
  •  go-up   go-down


18. Poliani PL, Sperli D, Valentini S, Armentano A, Bercich L, Bonetti MF, Corriero G, Brisigotti M, Quattrone A, Lanza PL: Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case. Neuropathology; 2009 Oct;29(5):574-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case.
  • In the present report we describe a case of a 15-month-old child with a spinal GTNI of the cervical region and meningeal dissemination.
  • Histologically the tumor was composed of round, small neurocytic-like cells arranged around eosinophilic neuropil cores and embedded in a diffuse fibrillar glial component forming prominent "rosetted" neuropil islands displaying strong immunoreactivity for neuronal markers.
  • Cerebral GTNI shows abundant glial components not rarely exhibiting anaplastic features that justify their inclusion within the group of diffuse astrocytomas.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19077041.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  •  go-up   go-down


19. Armand JP, Ribrag V, Harrousseau JL, Abrey L: Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. Ther Clin Risk Manag; 2007 Jun;3(2):213-24
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Procarbazine alone, or more commonly combined in the PCV (procarbazine, lomustine [CCNU], and vincristine) regimen, is also effective in treating gliomas comprising astrocytomas, glioblastomas, and oligodendrogliomas.
  • In conclusion, the use of procarbazine in combination with other drugs means that it remains a major anticancer drug in the management of Hodgkin's lymphoma and gliomas.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Eur J Cancer. 1966 Feb;2(1):51-7 [5962294.001]
  • [Cites] Ann Intern Med. 1984 May;100(5):651-6 [6370065.001]
  • [Cites] Fertil Steril. 1983 Jan;39(1):97-102 [6848396.001]
  • [Cites] Arch Toxicol. 1980 Nov;46(1-2):139-49 [7235990.001]
  • [Cites] Cancer. 1991 Jul 1;68(1):22-9 [2049748.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1990 Feb;18(2):321-4 [2154418.001]
  • [Cites] Cancer Res. 1990 Oct 1;50(19):6119-29 [2205376.001]
  • [Cites] J Clin Oncol. 1990 Dec;8(12):2014-8 [2230893.001]
  • [Cites] Experientia. 1963 Mar 15;19:132-3 [13971061.001]
  • [Cites] J Clin Oncol. 1994 Jul;12(7):1366-74 [7517442.001]
  • [Cites] Cancer. 1994 Dec 1;74(11):3029-33 [7525042.001]
  • [Cites] Neurosurgery. 1996 Nov;39(5):921-6 [8905746.001]
  • [Cites] Baillieres Clin Haematol. 1996 Sep;9(3):401-16 [8922237.001]
  • [Cites] Cancer. 1997 Jun 15;79(12):2409-13 [9191531.001]
  • [Cites] Cancer Res. 1997 Jul 15;57(14):2933-6 [9230204.001]
  • [Cites] J Neurooncol. 1998 Apr;37(2):155-60 [9524094.001]
  • [Cites] Leukemia. 1998 Sep;12(9):1457-60 [9737696.001]
  • [Cites] J Clin Oncol. 1999 Feb;17(2):645-50 [10080610.001]
  • [Cites] J Clin Oncol. 1999 Nov;17(11):3389-95 [10550132.001]
  • [Cites] Neurosurgery. 2000 Jan;46(1):51-60; discussion 60-1 [10626935.001]
  • [Cites] Neurology. 2000 Apr 25;54(8):1707-8 [10762527.001]
  • [Cites] Jpn J Clin Oncol. 2000 Mar;30(3):146-52 [10798542.001]
  • [Cites] Cancer. 2000 May 1;88(9):2142-8 [10813727.001]
  • [Cites] Br J Cancer. 2000 Sep;83(5):588-93 [10944597.001]
  • [Cites] J Clin Oncol. 2000 Sep;18(17):3144-50 [10963643.001]
  • [Cites] Clin Cancer Res. 2000 Oct;6(10):3878-84 [11051233.001]
  • [Cites] Ann Oncol. 2000 Sep;11(9):1105-14 [11061603.001]
  • [Cites] J Clin Oncol. 2001 Jan 15;19(2):509-18 [11208845.001]
  • [Cites] Neuro Oncol. 2000 Jan;2(1):22-8 [11302250.001]
  • [Cites] Ann Oncol. 2002;13 Suppl 1:107-11 [12078889.001]
  • [Cites] Blood. 2002 Sep 15;100(6):1989-96 [12200357.001]
  • [Cites] J Clin Oncol. 2003 Jan 15;21(2):251-5 [12525516.001]
  • [Cites] J Clin Oncol. 2003 Feb 15;21(4):607-14 [12586796.001]
  • [Cites] Ann Anat. 2003 Apr;185(2):117-9 [12725435.001]
  • [Cites] N Engl J Med. 2003 Jun 12;348(24):2386-95 [12802024.001]
  • [Cites] J Clin Oncol. 2003 Jul 15;21(14):2726-31 [12860951.001]
  • [Cites] Br J Cancer. 2003 Jul 21;89(2):248-51 [12865911.001]
  • [Cites] J Chemother. 1992 Apr;4(2):123-6 [1321239.001]
  • [Cites] N Engl J Med. 1992 Nov 19;327(21):1478-84 [1383821.001]
  • [Cites] Experientia. 1963 Mar 15;19:130-1 [13968615.001]
  • [Cites] Blood. 2006 Jun 15;107(12):4636-42 [16478882.001]
  • [Cites] Leuk Lymphoma. 2006 Apr;47(4):637-40 [16690522.001]
  • [Cites] J Clin Oncol. 2006 Jun 20;24(18):2715-22 [16782911.001]
  • [Cites] Clin Cancer Res. 2006 Sep 1;12(17):5174-81 [16951236.001]
  • [Cites] Eur J Cancer. 2006 Nov;42(17):2939-45 [16962317.001]
  • [Cites] Rev Neurol (Paris). 2006 Nov;162(11):1069-75 [17086143.001]
  • [Cites] Experientia. 1963 Mar 15;19:131-2 [13975694.001]
  • [Cites] Experientia. 1963 Mar 15;19:129 [14003433.001]
  • [Cites] Ann Intern Med. 1965 Jul;63:69-86 [14305970.001]
  • [Cites] Eur J Cancer. 2004 Sep;40(13):1924-7 [15315798.001]
  • [Cites] Cancer. 2004 Nov 1;101(9):2079-85 [15372474.001]
  • [Cites] Cancer. 2005 Feb 15;103(4):802-9 [15637687.001]
  • [Cites] J Clin Oncol. 2005 Dec 20;23(36):9198-207 [16172458.001]
  • [Cites] Leuk Lymphoma. 2005 Nov;46(11):1561-7 [16236610.001]
  • [Cites] Anticancer Drugs. 2006 Jan;17(1):75-80 [16317293.001]
  • [Cites] Clin Cancer Res. 2006 Jan 15;12(2):529-35 [16428496.001]
  • [Cites] Cancer. 1989 Dec 15;64(12):2420-3 [2555038.001]
  • [Cites] Neurology. 1989 Jun;39(6):789-96 [2725874.001]
  • [Cites] Cancer Res. 1989 Jan 1;49(1):127-33 [2908840.001]
  • [Cites] J Neurosurg. 1985 Aug;63(2):218-23 [2991486.001]
  • [Cites] Cancer Chemother Pharmacol. 1987;19(2):91-102 [3552281.001]
  • [Cites] J Clin Oncol. 1985 Jun;3(6):769-75 [3839262.001]
  • [Cites] Lancet. 1975 Feb 1;1(7901):248-50 [46388.001]
  • [Cites] Cancer. 1970 May;25(5):1018-25 [4910254.001]
  • [Cites] Cancer. 1971 Aug;28(2):306-17 [4935774.001]
  • [Cites] Br Med J. 1970 Jul 4;3(5713):7-10 [5427500.001]
  • [Cites] Ann Intern Med. 1970 Dec;73(6):881-95 [5525541.001]
  • [Cites] Dtsch Med Wochenschr. 1966 Jan 14;91(2):55-7 [5900941.001]
  • (PMID = 18360630.001).
  • [ISSN] 1176-6336
  • [Journal-full-title] Therapeutics and clinical risk management
  • [ISO-abbreviation] Ther Clin Risk Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC1936303
  •  go-up   go-down


20. Shukla K, Parikh B, Shukla J, Trivedi P, Shah B: Accuracy of cytologic diagnosis of central nervous system tumours in crush preparation. Indian J Pathol Microbiol; 2006 Oct;49(4):483-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common tumor in intracranial cavity was astrocytoma (56.68%), followed by meningioma (6.88%), medulloblastoma (5.66%) and ependymoma (5.56%).
  • The most common tumor in intraspinal cavity was ependymoma (38.46%), followed by meningioma (23.07%) and schwannoma (23.07%).
  • [MeSH-major] Astrocytoma. Central Nervous System Neoplasms / diagnosis. Cytodiagnosis. Ependymoma. Medulloblastoma. Meningioma. Neurilemmoma

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17183833.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] India
  •  go-up   go-down


21. Choi WH, Ji KA, Jeon SB, Yang MS, Kim H, Min KJ, Shong M, Jou I, Joe EH: Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation. Biochem Biophys Res Commun; 2005 Apr 1;329(1):125-31
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In primary cultured rat brain astrocytes and C6 astroglioma cells, both cRA and tRA decreased IFN-gamma-induced expression of interferon regulatory factor-1.
  • Furthermore, the effect of pre-treated RA was abolished in the presence of cycloheximide, indicating a requirement for de novo protein synthesis.

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
  • Hazardous Substances Data Bank. ALL-TRANS-RETINOIC ACID .
  • Hazardous Substances Data Bank. CYCLOHEXIMIDE .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15721283.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / Protein Synthesis Inhibitors; 0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / STAT1 Transcription Factor; 0 / STAT3 Transcription Factor; 0 / Socs1 protein, rat; 0 / Socs3 protein, rat; 0 / Stat1 protein, rat; 0 / Stat3 protein, rat; 0 / Suppressor of Cytokine Signaling Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 5688UTC01R / Tretinoin; 82115-62-6 / Interferon-gamma; 98600C0908 / Cycloheximide; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Jak1 protein, rat; EC 2.7.10.2 / Jak2 protein, rat; EC 2.7.10.2 / Janus Kinase 1; EC 2.7.10.2 / Janus Kinase 2
  •  go-up   go-down


22. Becher OJ, Peterson KM, Khatua S, Santi MR, MacDonald TJ: IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK. J Child Neurol; 2008 Oct;23(10):1205-13
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
  • To identify targets critical to malignant childhood astrocytoma, we compared the expression of receptor tyrosine kinase- associated genes between low-grade and high-grade pediatric astrocytomas.
  • The highest differentially overexpressed gene in high-grade astrocytoma is insulin-like growth factor- binding protein-2 (P = .0006).
  • Insulin-like growth factor- binding protein-2 stimulation had no effect on astrocytoma cell growth and migration, and minimally inhibited insulin-like growth factor-1-mediated migration, but not insulin-like growth factor-2-mediated migration.
  • DNA-PKcs is also highly overexpressed by high-grade astrocytomas.
  • These findings suggest insulin-like growth factor-binding protein-2 plays a role in astrocytoma progression by promoting DNA-damage repair and therapeutic resistance.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Brain Pathol. 2000 Apr;10(2):249-59 [10764044.001]
  • [Cites] Cancer Res. 2003 Aug 1;63(15):4315-21 [12907597.001]
  • [Cites] Endocrinology. 2001 Apr;142(4):1652-8 [11250947.001]
  • [Cites] Neuro Oncol. 1999 Apr;1(2):109-19 [11550306.001]
  • [Cites] Nat Genet. 2001 Oct;29(2):143-52 [11544480.001]
  • [Cites] Cancer Res. 2001 Oct 15;61(20):7404-7 [11606370.001]
  • [Cites] Oncogene. 2001 Nov 8;20(51):7542-50 [11709726.001]
  • [Cites] Cancer Res. 2001 Dec 15;61(24):8601-10 [11751371.001]
  • [Cites] Mol Cells. 2002 Apr 30;13(2):159-66 [12018836.001]
  • [Cites] Cancer Res. 2002 Aug 1;62(15):4369-75 [12154042.001]
  • [Cites] J Clin Oncol. 2002 Oct 15;20(20):4209-16 [12377964.001]
  • [Cites] Am J Pathol. 2002 Nov;161(5):1587-95 [12414507.001]
  • [Cites] J Biol Chem. 2002 Nov 15;277(46):43830-5 [12235151.001]
  • [Cites] Gene Expr. 2003;11(1):35-45 [12691524.001]
  • [Cites] Cancer Res. 2003 Apr 15;63(8):1865-70 [12702575.001]
  • [Cites] FASEB J. 2003 Oct;17(13):1919-21 [14519668.001]
  • [Cites] Cancer Res. 2003 Sep 15;63(18):5850-8 [14522909.001]
  • [Cites] J Biol Chem. 2003 Oct 10;278(41):39882-91 [12881526.001]
  • [Cites] J Biol Chem. 2003 Oct 31;278(44):42886-92 [12917428.001]
  • [Cites] Cancer Res. 2003 Oct 15;63(20):6613-25 [14583454.001]
  • [Cites] Cancer Res. 2003 Oct 15;63(20):6962-70 [14583498.001]
  • [Cites] Nucleic Acids Res. 2003 Dec 15;31(24):7227-37 [14654698.001]
  • [Cites] Oncogene. 2004 Jan 29;23(4):873-82 [14661061.001]
  • [Cites] Cancer Res. 2004 Feb 1;64(3):977-84 [14871828.001]
  • [Cites] Int J Cancer. 1992 Jan 21;50(2):215-22 [1370435.001]
  • [Cites] J Neurosci. 1992 Dec;12(12):4737-44 [1281494.001]
  • [Cites] Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10553-7 [7504269.001]
  • [Cites] J Clin Endocrinol Metab. 1994 Aug;79(2):428-34 [7519190.001]
  • [Cites] J Neurosurg. 1994 Sep;81(3):427-36 [8057151.001]
  • [Cites] Cancer. 1995 Jan 1;75(1 Suppl):395-405 [8001010.001]
  • [Cites] J Neurosurg. 1997 May;86(5):747-54 [9126887.001]
  • [Cites] Semin Surg Oncol. 1998 Jan-Feb;14(1):3-12 [9407626.001]
  • [Cites] Oncology (Williston Park). 1998 Feb;12(2):233-40; discussion 240, 246 [9507524.001]
  • [Cites] J Neurosurg. 1998 Jul;89(1):52-9 [9647172.001]
  • [Cites] Clin Exp Metastasis. 1998 Nov;16(8):729-41 [10211986.001]
  • [Cites] Clin Cancer Res. 1999 Jul;5(7):1786-92 [10430083.001]
  • [Cites] Cancer Res. 1999 Sep 1;59(17):4228-32 [10485462.001]
  • [Cites] Cancer Res. 2005 May 15;65(10):4368-75 [15899829.001]
  • [Cites] J Biol Chem. 2005 Sep 2;280(35):31182-9 [16000298.001]
  • [Cites] Int J Cancer. 2005 Nov 20;117(4):531-7 [15929110.001]
  • [Cites] Neuro Oncol. 2005 Oct;7(4):485-94 [16212813.001]
  • [Cites] Virchows Arch. 2003 Apr;442(4):329-35 [12684767.001]
  • [Cites] Neurosurgery. 2003 Jun;52(6):1391-9; discussion 1399 [12762884.001]
  • [Cites] Neurosurgery. 2003 Jun;52(6):1425-34; discussion 1434-5 [12762887.001]
  • [Cites] Anticancer Res. 2003 May-Jun;23(3B):2315-20 [12894509.001]
  • [Cites] Cancer Res. 2000 Dec 1;60(23):6617-22 [11118044.001]
  • (PMID = 18952587.001).
  • [ISSN] 1708-8283
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K08 CA092056; United States / NINDS NIH HHS / NS / R13 NS040925; United States / NINDS NIH HHS / NS / 5R13NS040925-09; United States / NCI NIH HHS / CA / K08 CA92056-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin-Like Growth Factor Binding Protein 2; 0 / Nuclear Proteins; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.11.1 / DNA-Activated Protein Kinase; EC 2.7.11.1 / PRKDC protein, human
  • [Other-IDs] NLM/ NIHMS473094; NLM/ PMC3674842
  •  go-up   go-down


23. Harris JE, Friedland JS: l-Glutamate in Middlebrook 7H9 culture medium upregulates matrix metalloproteinase-2 secretion from human astrocytoma cells. J Neurosci Methods; 2008 Aug 30;173(2):291-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] l-Glutamate in Middlebrook 7H9 culture medium upregulates matrix metalloproteinase-2 secretion from human astrocytoma cells.
  • Whilst investigating the secretion of MMP-2 from human U373-MG astrocytoma cells, we observed elevated MMP-2 secretion in response to Middlebrook 7H9 media but not to Mycobacterium tuberculosis itself.
  • Middlebrook 7H9 media did not stimulate MMP-1 or MMP-9 secretion from astrocytoma cells.
  • The excitatory neurotransmitter l-glutamate, at concentrations found in Middlebrook 7H9 media, induced significant astrocytoma MMP-2 secretion (p<0.05).
  • l-Glutamate-induced MMP-2 activity may contribute to neuropathology in various CNS diseases and may generate misleading data in pathogen studies where Middlebrook 7H9 is the culture medium.
  • [MeSH-minor] Astrocytoma. Cell Culture Techniques / standards. Cell Line, Tumor. Diagnostic Errors / prevention & control. Extracellular Matrix / drug effects. Extracellular Matrix / enzymology. Extracellular Matrix / microbiology. Humans. Mycobacterium tuberculosis / drug effects. Mycobacterium tuberculosis / enzymology. Reagent Kits, Diagnostic / standards. Up-Regulation / drug effects. Up-Regulation / physiology

  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. GLUTAMIC ACID HYDROCHLORIDE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18611410.001).
  • [ISSN] 0165-0270
  • [Journal-full-title] Journal of neuroscience methods
  • [ISO-abbreviation] J. Neurosci. Methods
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Culture Media; 0 / Reagent Kits, Diagnostic; 3KX376GY7L / Glutamic Acid; EC 3.4.24.24 / Matrix Metalloproteinase 2
  •  go-up   go-down


24. Hamada H, Kurimoto M, Hayashi N, Nagai S, Kurosaki K, Nomoto K, Kanegane H, Nomura K, Endo S: Pilomyxoid astrocytoma in a patient presenting with fatal hemorrhage. Case report. J Neurosurg Pediatr; 2008 Mar;1(3):244-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilomyxoid astrocytoma in a patient presenting with fatal hemorrhage. Case report.
  • The authors report on a rare case of pilomyxoid astrocytoma in a patient presenting with fatal hemorrhage.
  • Because the pathological diagnosis was pilomyxoid astrocytoma, chemotherapy was administered.
  • In this report, the authors review the literature and discuss the clinical features and treatment of pilomyxoid astrocytoma.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Cerebral Hemorrhage / diagnosis

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18352771.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
  •  go-up   go-down


25. Rashid MH, Ahmad SU, Rahman MH, Raihan MZ, Sayed MA: Surgical outcome of low grade astrocytoma of brain. Mymensingh Med J; 2010 Apr;19(2):185-90
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcome of low grade astrocytoma of brain.
  • This study was carried out in the department of Neurosurgery, Dhaka Medical College Hospital, Dhaka, Bangladesh, during the period of January 2003 to December 2006 to elucidate the effectiveness of surgical treatment in the management of low grade astrocytoma of brain.
  • For this purpose, a total number of 50 cases admitted during the study period with low grade astrocytoma of brain supported by clinical features and radiological investigations (CT and MRI scan) were included in this study.
  • Out of 50 patients 60.0% had gross total removal of tumor and 40.0% sub total tumor resection.
  • Histopathological study was done in all cases after tumor resection.
  • Among the gross total tumor removal cases highest percentage had good recovery (93.4%) in the immediate post operative period.
  • Another 2(4.0%), those underwent subtotal tumor resection died during subsequent follow up period at 8th and 14th postoperative day.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20395910.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Bangladesh
  • [Chemical-registry-number] 0 / Contrast Media
  •  go-up   go-down


26. Giffoni SD, Cendes F, Valente M, Gil-da-Silva-Lopes VL: Midline facial defects with hypertelorism and low-grade astrocytoma: a previously undescribed association. Cleft Palate Craniofac J; 2006 Nov;43(6):748-51
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Midline facial defects with hypertelorism and low-grade astrocytoma: a previously undescribed association.
  • We report on a child with midline facial defects with hypertelorism (MFDH), median cleft lip, sphenoidal ventriculocele, partial agenesis of the corpus callosum, and low-grade astrocytoma in the cervicomedullary junction.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Craniofacial Abnormalities / complications. Hypertelorism / complications


27. Hayashi S, Yamamoto M, Tachibana K, Ueno Y, Bu G, Fukushima T: Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death. Anticancer Res; 2009 Mar;29(3):897-905
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death.
  • BACKGROUND: Low-intensity ultrasound showed tumor cell killing by a non-thermal effect in human leukemia cells.
  • The aim of our study was to investigate the efficacy of low-intensity ultrasound on malignant astrocytic tumor cells with the photosensitizer, Photofrin, which is taken up by the cell surface receptor, low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP/alpha2MR).
  • MATERIALS AND METHODS: Cells were sonicated with continuous wave ultrasound with or without the presence of Photofrin (75 mg/ml) at an intensity of 0.3 W/cm(2) for a duration of 5, 15, or 30 s.
  • RESULTS: Ultrasound alone induced instant cell killing immediately after sonication in both U251MG and U105MG malignant gliomas cells.
  • CONCLUSION: This is the first report to demonstrate the usefulness of low-intensity ultrasound for the cell killing of malignant glioma cells.
  • [MeSH-major] Brain Neoplasms / therapy. Cell Survival / drug effects. Dihematoporphyrin Ether / therapeutic use. Glioma / therapy. Photosensitizing Agents / therapeutic use. Ultrasonic Therapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Low Density Lipoprotein Receptor-Related Protein-1 / genetics. Low Density Lipoprotein Receptor-Related Protein-1 / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured. alpha-Macroglobulins / genetics. alpha-Macroglobulins / metabolism

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19414325.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Low Density Lipoprotein Receptor-Related Protein-1; 0 / Photosensitizing Agents; 0 / RNA, Messenger; 0 / alpha-Macroglobulins; 97067-70-4 / Dihematoporphyrin Ether
  •  go-up   go-down


28. Ishii D, Natsume A, Wakabayashi T, Hatano H, Asano Y, Takeuchi H, Shimato S, Ito M, Fujii M, Yoshida J: Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant gliomas. Neurol Med Chir (Tokyo); 2007 Aug;47(8):341-9; discussion 350
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant gliomas.
  • Promoter methylation of the deoxyribonucleic acid (DNA) repair gene, O(6)-methylguanine-DNA methyltransferase (MGMT), is associated with improved outcome of patients with glioblastoma multiforme and anaplastic astrocytoma treated with temozolomide (TMZ).
  • Molecular genetic analysis of loss of heterozygosity (LOH) of 1p, 19q, or 10q, p53 mutation, and MGMT promoter methylation was performed in 44 assessable tumor specimens obtained from 46 patients with recurrent malignant gliomas, including 21 with glioblastoma multiforme, 17 with anaplastic astrocytoma, and eight with anaplastic oligoastrocytoma, which have heterogeneous features and variable histological diagnosis, to assess the correlation with the response to TMZ.
  • LOH of 1p in the heterogeneous population of malignant gliomas may be one of the important factors besides MGMT methylation that predict better outcome in patients treated with TMZ.
  • [MeSH-major] Brain Neoplasms / genetics. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Dacarbazine / analogs & derivatives. Drug Resistance, Neoplasm / genetics. Glioma / genetics. Mutation / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents, Alkylating / pharmacology. Antineoplastic Agents, Alkylating / therapeutic use. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. DNA Methylation. DNA Mutational Analysis. DNA Repair / genetics. Female. Genetic Markers / genetics. Genetic Predisposition to Disease / genetics. Genetic Testing. Humans. Loss of Heterozygosity / genetics. Male. Middle Aged. Promoter Regions, Genetic / genetics. Survival Rate

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • Hazardous Substances Data Bank. DACARBAZINE .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17721049.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Biomarkers, Tumor; 0 / Genetic Markers; 0 / Tumor Suppressor Proteins; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
  •  go-up   go-down


29. Robe PA, Martin D, Albert A, Deprez M, Chariot A, Bours V: A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668]. BMC Cancer; 2006;6:29
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668].
  • BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen.
  • Indeed, the median survival of glioblastoma multiforme (WHO grade 4) patients is at best 14.6 month with only 26.5 percent of the patients still alive after 2 years and the median survival of anaplastic astrocytomas (WHO grade 3) is 19.2 month.
  • Recent evidence suggests that the transcription factor NF-kappaB is constitutively expressed in malignant gliomas and that its inhibition by drugs like Sulfasalazine may block the growth of astrocytic tumors in vitro and in experimental models of malignant gliomas.
  • A total of twenty patients with progressive malignant glioma despite surgery, radiation therapy and a first line of chemotherapy will be recruited and assigned to four dosage regimen of Sulfasalazine.
  • Primary endpoints are drug safety in the setting of malignant gliomas and tumor response as measured according to MacDonald's criteria.
  • DISCUSSION: The aim of this study is to evaluate the safety and efficacy of Sulfasalazine as a treatment for recurring malignant gliomas.
  • [MeSH-minor] Administration, Oral. Adult. Aged. Brain Neoplasms. Disease Progression. Double-Blind Method. Female. Glioma. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Survival Analysis. Treatment Outcome

  • Hazardous Substances Data Bank. SULFASALAZINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Biochem Pharmacol. 2000 Oct 15;60(8):1085-9 [11007945.001]
  • [Cites] Oncogene. 1999 Nov 22;18(49):6938-47 [10602468.001]
  • [Cites] Exp Cell Res. 2001 May 1;265(2):221-33 [11302687.001]
  • [Cites] Semin Oncol. 2002 Dec;29(6 Suppl 17):17-20 [12520480.001]
  • [Cites] Oncogene. 2003 Jan 9;22(1):90-7 [12527911.001]
  • [Cites] Oncologist. 2003;8(6):508-13 [14657528.001]
  • [Cites] Lab Invest. 2004 Aug;84(8):941-51 [15184909.001]
  • [Cites] Clin Cancer Res. 2004 Aug 15;10(16):5595-603 [15328202.001]
  • [Cites] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840.001]
  • [Cites] Drugs. 1995 Jul;50(1):137-56 [7588084.001]
  • [Cites] J Clin Invest. 1998 Mar 1;101(5):1163-74 [9486988.001]
  • [Cites] J Neurosurg. 1999 Jan;90(1):72-7 [10413158.001]
  • [Cites] Neurosurgery. 1999 Sep;45(3):423-31; discussion 431-3 [10493363.001]
  • [Cites] Oncogene. 2005 Jan 13;24(3):344-54 [15531918.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009.001]
  • [Cites] J Neuropathol Exp Neurol. 2005 Jun;64(6):479-89 [15977639.001]
  • [Cites] Gastroenterology. 2000 Nov;119(5):1209-18 [11054378.001]
  • (PMID = 16448552.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Databank-accession-numbers] ISRCTN/ ISRCTN45828668
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 3XC8GUZ6CB / Sulfasalazine
  • [Other-IDs] NLM/ PMC1368982
  •  go-up   go-down


30. Ishihara R, Katayama Y, Watanabe T, Yoshino A, Fukushima T, Sakatani K: Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas. Neurol Med Chir (Tokyo); 2007 Feb;47(2):53-7; discussion 57
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas.
  • The fluorescence of protoporphyrin IX (PpIX) induced endogenously by 5-aminolevulinic acid (5-ALA) administration has recently been used for the intraoperative visualization of glioma tissues.
  • To increase the sensitivity of photodetection, the emission spectra of 5-ALA-induced PpIX fluorescence was quantitatively measured in tissues taken from six cases of en bloc resected diffusely infiltrating astrocytomas (2 diffuse astrocytomas, 2 anaplastic astrocytomas, and 2 glioblastomas), and the correlation assessed between the fluorescence intensity and histological features.
  • The ratio of the peak emission intensity to reflected excitation intensity or fluorescence intensity ratio was less than 0.001 for all 36 non-tumor tissues.
  • The MIB-1 proliferation index was the most powerful determinant, suggesting that higher cell proliferation may govern preferential PpIX accumulation in glioma cells.
  • This preliminary study suggests that spectroscopic analysis may be useful for optimizing the removal of diffuse gliomas.
  • [MeSH-major] Astrocytoma / chemistry. Astrocytoma / pathology. Brain Neoplasms / chemistry. Brain Neoplasms / pathology. Protoporphyrins / analysis
  • [MeSH-minor] Aged. Aminolevulinic Acid. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Photosensitizing Agents. Spectrometry, Fluorescence

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17317941.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Protoporphyrins; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
  •  go-up   go-down


31. Yamada K, Takeshima H, Sakurama T, Kuratsu J: Secondary cervical dystonia following stereotactic radiosurgery in a patient with thalamic glioma. Surg Neurol; 2007 Dec;68(6):665-70
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary cervical dystonia following stereotactic radiosurgery in a patient with thalamic glioma.
  • We report the first patient with secondary CD after stereotactic radiosurgery for thalamic glioma.
  • CASE DESCRIPTION: A 27-year-old woman complaining of headache and left motor weakness was found to have a thalamic tumor on the right side.
  • Histopathologically, tumor samples manifested features of anaplastic astrocytoma.
  • [MeSH-major] Brain Neoplasms / surgery. Glioma / surgery. Postoperative Complications / etiology. Radiosurgery / adverse effects. Torticollis / etiology


32. Shields CL, Materin MA, Shields JA: Review of optical coherence tomography for intraocular tumors. Curr Opin Ophthalmol; 2005 Jun;16(3):141-54
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • With regard to ocular oncology, optical coherence tomography can illustrate retinal changes overlying choroidal tumors.
  • SUMMARY: Optical coherence tomography of retinal tumors, such as retinoblastoma and astrocytic hamartoma, reveals full-thickness replacement of the retinal anatomic layers with the tumor and shadowing corresponding to the intralesional calcification.

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15870570.001).
  • [ISSN] 1040-8738
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 46
  •  go-up   go-down


33. Hales RK, Shokek O, Burger PC, Paynter NP, Chaichana KL, Quiñones-Hinojosa A, Jallo GI, Cohen KJ, Song DY, Carson BS, Wharam MD: Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. J Neurooncol; 2010 Aug;99(1):65-71
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis.
  • To characterize a population of pediatric high-grade astrocytoma (HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria.
  • Log-rank analysis was used to compare survival by patient, tumor, and treatment factors.
  • Pathologic misdiagnosis should be suspected in patients who are long term survivors of a pediatric high grade astrocytoma.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • MedlinePlus Health Information. consumer health - Children's Health.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer. 2003 Sep 15;98(6):1243-52 [12973849.001]
  • [Cites] Brain Pathol. 1993 Jul;3(3):255-68 [8293185.001]
  • [Cites] Clin Cancer Res. 1999 Jul;5(7):1786-92 [10430083.001]
  • [Cites] J Natl Cancer Inst. 1993 May 5;85(9):704-10 [8478956.001]
  • [Cites] Br J Cancer. 2004 Aug 2;91(3):425-9 [15266331.001]
  • [Cites] Pediatr Neurosurg. 1994;20(4):226-32 [8043460.001]
  • [Cites] Curr Treat Options Oncol. 2001 Dec;2(6):529-36 [12057098.001]
  • [Cites] J Clin Oncol. 2000 Mar;18(6):1246-53 [10715294.001]
  • [Cites] J Neurol. 2000 Jun;247(6):455-60 [10929275.001]
  • [Cites] Cancer J. 2003 Mar-Apr;9(2):107-12 [12784876.001]
  • [Cites] J Clin Oncol. 2006 Jun 1;24(16):2563-9 [16735709.001]
  • [Cites] J Clin Oncol. 2002 May 1;20(9):2267-76 [11980997.001]
  • [Cites] AJR Am J Roentgenol. 2001 Aug;177(2):449-54 [11461881.001]
  • [Cites] Arch Neurol. 1999 Apr;56(4):421-5 [10199329.001]
  • [Cites] J Clin Oncol. 2002 Apr 15;20(8):2076-84 [11956268.001]
  • [Cites] J Neurosurg. 1978 Sep;49(3):333-43 [355604.001]
  • [Cites] Acta Neuropathol. 2007 Aug;114(2):97-109 [17618441.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1996 Oct 1;36(3):549-56 [8948338.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1998 Jan 1;40(1):51-5 [9422557.001]
  • [Cites] Neuro Oncol. 1999 Jan;1(1):14-25 [11554386.001]
  • [Cites] Cancer. 2000 Jun 15;88(12):2887 [10870076.001]
  • [Cites] Am J Pathol. 2001 Apr;158(4):1525-32 [11290570.001]
  • [Cites] Neuro Oncol. 2003 Jul;5(3):197-207 [12816726.001]
  • [Cites] Cancer Res. 2001 Mar 1;61(5):2124-8 [11280776.001]
  • [Cites] Cancer. 1987 Oct 1;60(7):1651-6 [3621134.001]
  • [Cites] Cancer Res. 2001 Oct 15;61(20):7404-7 [11606370.001]
  • [Cites] Cancer. 2004 Aug 15;101(4):817-24 [15305415.001]
  • [Cites] Childs Nerv Syst. 2008 Apr;24(4):467-75 [17978821.001]
  • [Cites] Neurosurgery. 2002 Jun;50(6):1238-44; discussion 1244-5 [12015841.001]
  • [Cites] Brain Pathol. 2000 Apr;10 (2):249-59 [10764044.001]
  • [Cites] Lancet Oncol. 2008 Jan;9(1):29-38 [18082451.001]
  • [Cites] Clin Cancer Res. 2004 Dec 15;10(24):8220-8 [15623597.001]
  • [Cites] J Neurosurg. 1998 Jan;88(1):1-10 [9420066.001]
  • [Cites] Neurosurgery. 1996 Feb;38(2):258-64 [8869052.001]
  • [Cites] Cancer. 2000 Nov 15;89(10):2131-7 [11066055.001]
  • [Cites] J Neurosurg. 2003 Sep;99(3):467-73 [12959431.001]
  • [Cites] Neuroradiology. 1980;19(2):59-66 [6245388.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1979 Oct;5(10):1725-31 [231022.001]
  • [Cites] Cancer Res. 2006 Dec 1;66(23):11172-8 [17145861.001]
  • (PMID = 20043190.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


34. Li M, Jia ZZ, Gu HM, Zhou XJ, Tang LM: [Application of apparent diffusion coefficient and fractional anisotropy in identification of tumor component and grading of brain astrocytoma]. Zhonghua Yi Xue Za Zhi; 2008 Dec 23;88(47):3352-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Application of apparent diffusion coefficient and fractional anisotropy in identification of tumor component and grading of brain astrocytoma].
  • OBJECTIVE: To evaluate the value of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in identification of tumor element and grading of brain astrocytoma.
  • METHODS: Thirty-three patients with histologically confirmed astrocytoma underwent diffusion weighted imaging (DWI), diffusion tensor imaging (DTI), and conventional MRI before operation.
  • The values of ADC and FA of different regions in the same tumor and of astrocytoma of different grades were measured and compared.
  • RESULTS: The ADC values of the tumor parenchyma, necrotic region, peritumoral edema region were (1.28 +/- 0.44), (1.97 +/- 0.53), and (1.74 +/- 0.47) respectively, all significantly higher than that of the corresponding normal brain tissues [(0.80 +/- 0.18), P = 0.009, P = 0.000, P = 0.000] with significantly differences between the tumor parenchyma and necrotic region and peritumoral edema region (both P < 0.05), however, there was not significant difference between the necrotic region and peritumoral edema region.
  • The FA values of the tumor parenchyma, necrotic region, and peritumoral edema region were (0.18 +/- 0.07), (0.14 +/- 0.05), and (0.16 +/- 0.05) respectively, all significantly higher than that of the corresponding normal brain tissues [(0.58 +/- 0.10), all P = 0.000], without significant differences among the former 3 groups.
  • There were no significant differences in the ADC and FA values among the tumors at different grades, however, there was a tendency of ADC to decrease and of FA to increase along the increase of grade of tumor, although not significantly.
  • CONCLUSION: ADC value plays an important part in distinguishing tumor components and determining tumor boundary, and plays a certain role in judging the grade of astrocytomas.
  • FA value is vital to determine the tumor boundary, and has certain value in differentiating high-grade from low-grade astrocytomas.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Diffusion Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Anisotropy. Female. Humans. Male. Middle Aged. Neoplasm Staging

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19257968.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  •  go-up   go-down


35. Khalatbari M, Borghei-Razavi H, Shayanfar N, Behzadi AH, Sepehrnia A: Collision tumor of meningioma and malignant astrocytoma. Pediatr Neurosurg; 2010;46(5):357-61
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collision tumor of meningioma and malignant astrocytoma.
  • The pathology of tumors reported collision tumors composed of meningioma and malignant astrocytoma.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery

  • Genetic Alliance. consumer health - Meningioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21389747.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


36. Seyfried NT, Huysentruyt LC, Atwood JA 3rd, Xia Q, Seyfried TN, Orlando R: Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach. Cancer Lett; 2008 May 18;263(2):243-52
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach.
  • Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain tumor origin and malignancy.
  • In this study, membrane proteins were identified from a terminally differentiated mouse astrocyte (AC) and CT-2A astrocytoma (CT-2A) cell line using liquid-chromatography coupled with tandem mass spectrometry (LC-MS/MS).
  • Therefore, our data suggest that the CT-2A tumor may be derived from NG2 glia rather than from fully differentiated astrocytes.
  • Moreover, the CT-2A cells also express a series of interferon-induced signature proteins that may be specific to this tumor.
  • These data highlight the utility of LC-MS/MS for the identification of brain tumor membrane biomarkers.
  • [MeSH-major] Antigens / metabolism. Astrocytoma / metabolism. Brain Neoplasms / metabolism. Carrier Proteins / metabolism. Proteins / metabolism. Proteoglycans / metabolism. Proteomics
  • [MeSH-minor] Animals. Biomarkers, Tumor / analysis. Cell Line, Tumor. Cell Lineage. Chromatography, Liquid. Membrane Proteins / analysis. Mice. Tandem Mass Spectrometry. Up-Regulation

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Electrophoresis. 1999 Dec;20(18):3551-67 [10612281.001]
  • [Cites] Adv Exp Med Biol. 2007;607:73-83 [17977460.001]
  • [Cites] Perspect Biol Med. 2001 Spring;44(2):263-82 [11370160.001]
  • [Cites] Chem Rev. 2001 Feb;101(2):269-95 [11712248.001]
  • [Cites] Nat Biotechnol. 2003 Mar;21(3):262-7 [12610573.001]
  • [Cites] Nat Biotechnol. 2003 May;21(5):532-8 [12692561.001]
  • [Cites] J Neurocytol. 2002 Jul-Aug;31(6-7):423-35 [14501214.001]
  • [Cites] J Neurocytol. 2002 Jul-Aug;31(6-7):437-55 [14501215.001]
  • [Cites] J Neurocytol. 2002 Jul-Aug;31(6-7):507-21 [14501220.001]
  • [Cites] Cancer Treat Res. 2004;117:263-84 [15015565.001]
  • [Cites] Mol Biol Cell. 2004 Aug;15(8):3580-90 [15181153.001]
  • [Cites] Philos Trans R Soc Lond B Biol Sci. 2004 May 29;359(1445):851-6 [15293812.001]
  • [Cites] Brain Res. 1984 Jul 23;306(1-2):283-91 [6466977.001]
  • [Cites] Anal Biochem. 1987 Nov 1;166(2):368-79 [2449095.001]
  • [Cites] J Neurosurg. 1990 Jun;72(6):941-5 [2159987.001]
  • [Cites] Eur J Biochem. 1991 Jul 15;199(2):417-23 [1906403.001]
  • [Cites] Mol Chem Neuropathol. 1992 Oct;17(2):147-67 [1418222.001]
  • [Cites] Int J Cancer. 1994 Sep 1;58(5):700-5 [8077056.001]
  • [Cites] Biochem Biophys Res Commun. 1999 May 19;258(3):583-91 [10329429.001]
  • [Cites] Nat Biotechnol. 2004 Nov;22(11):1459-66 [15529173.001]
  • [Cites] Nature. 2004 Nov 18;432(7015):396-401 [15549107.001]
  • [Cites] Prog Neurobiol. 2005 Apr;75(5):321-41 [15913880.001]
  • [Cites] Mol Cell Proteomics. 2005 Jun;4(6):762-72 [15703444.001]
  • [Cites] Dev Biol. 2005 Aug 1;284(1):1-11 [15963490.001]
  • [Cites] Biochem Biophys Res Commun. 2005 Sep 16;335(1):27-35 [16051185.001]
  • [Cites] N Engl J Med. 2005 Aug 25;353(8):811-22 [16120861.001]
  • [Cites] Oncogene. 2005 Sep 22;24(42):6367-75 [16007187.001]
  • [Cites] Cell Prolif. 2005 Dec;38(6):423-33 [16300654.001]
  • [Cites] Dev Cell. 2005 Dec;9(6):745-56 [16326387.001]
  • [Cites] Nat Rev Cancer. 2005 Nov;5(11):899-904 [16327766.001]
  • [Cites] Curr Opin Immunol. 2006 Feb;18(1):92-7 [16343885.001]
  • [Cites] Proteomics. 2006 Jan;6(1):153-71 [16342139.001]
  • [Cites] Cancer Res. 2006 Feb 15;66(4):1949-55 [16488993.001]
  • [Cites] J Cell Biochem. 2006 May 1;98(1):115-27 [16365873.001]
  • [Cites] J Immunol. 2006 Sep 1;177(5):3260-5 [16920966.001]
  • [Cites] J Neurochem. 2006 Sep;98(6):1973-84 [16911584.001]
  • [Cites] Glycobiology. 2006 Nov;16(11):137R-157R [16840800.001]
  • [Cites] Clin Immunol. 2006 Nov;121(2):144-58 [16904380.001]
  • [Cites] Clin Immunol. 2006 Nov;121(2):159-76 [16920030.001]
  • [Cites] Cancer Res. 2006 Nov 15;66(22):10815-23 [17090523.001]
  • [Cites] Nature. 2006 Dec 7;444(7120):756-60 [17051156.001]
  • [Cites] Mol Syst Biol. 2007;3:109 [17486137.001]
  • [Cites] Brain Cell Biol. 2006 Jun;35(2-3):159-72 [17957481.001]
  • [Cites] J Mol Biol. 2001 Jan 19;305(3):567-80 [11152613.001]
  • (PMID = 18281150.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P41 RR005351; United States / NCRR NIH HHS / RR / P41 RR005351; United States / NCRR NIH HHS / RR / P41 RR005351-20; United States / NCRR NIH HHS / RR / P41 RR018502
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Ifit1 protein, mouse; 0 / Ifit3 protein, mouse; 0 / Membrane Proteins; 0 / Proteins; 0 / Proteoglycans; 0 / chondroitin sulfate proteoglycan 4
  • [Other-IDs] NLM/ NIHMS48651; NLM/ PMC2726046
  •  go-up   go-down


37. Laczko R, Szauter KM, Jansen MK, Hollosi P, Muranyi M, Molnar J, Fong KS, Hinek A, Csiszar K: Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes. Neuropathol Appl Neurobiol; 2007 Dec;33(6):631-43
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We have recently reported the ECM enzyme, lysyl oxidase (LOX), in the central nervous system and observed up-regulation of LOX in anaplastic astrocytoma cells.
  • Results demonstrate that increased expression and activity of LOX positively correlated with invasive phenotype of malignant astrocytoma cell lines.
  • Immunohistochemistry detected increased LOX within tumour cells and ECM in grade I-IV astrocytic neoplasm compared with normal brain and coincidence of increased LOX with the loss of glial fibrillary acidic protein in higher-grade tumours.
  • [MeSH-minor] Astrocytoma / enzymology. Blotting, Western. Cell Line, Tumor. Cell Movement / physiology. Humans. Immunohistochemistry. Neoplasm Invasiveness. Reverse Transcriptase Polymerase Chain Reaction

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17931358.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR47713; United States / NCRR NIH HHS / RR / G12RR003096
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Paxillin; EC 1.4.3.13 / Protein-Lysine 6-Oxidase; EC 2.7.10.2 / Focal Adhesion Protein-Tyrosine Kinases
  •  go-up   go-down


38. Pusch L, Wegmann S, Caldwell JD, Jirikowski GF: Expression of corticosteroid-binding globulin in human astrocytoma cell line. Cell Mol Neurobiol; 2009 Jun;29(4):583-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of corticosteroid-binding globulin in human astrocytoma cell line.
  • Glial tumor cells are known to be sensitive to glucocorticoids (GC) in vivo and in vitro.
  • Here we studied the expression of corticosteroid-binding globulin (CBG) in the low-grade malignant human astrocytoma cell line 1321N1.
  • [MeSH-major] Astrocytoma / metabolism. Cell Line, Tumor. Transcortin / metabolism

  • Hazardous Substances Data Bank. DEXAMETHASONE .
  • Hazardous Substances Data Bank. HYDROCORTISONE .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Horm Metab Res. 2006 Apr;38(4):291-3 [16700011.001]
  • [Cites] Med Sci Monit. 2008 Oct;14(10):CR499-504 [18830188.001]
  • [Cites] Endocrinology. 1981 Aug;109(2):363-75 [7250045.001]
  • [Cites] Horm Metab Res. 2006 Apr;38(4):253-9 [16700007.001]
  • [Cites] Endocrinology. 2002 Oct;143(10):3866-74 [12239098.001]
  • [Cites] J Steroid Biochem Mol Biol. 1991;40(4-6):755-62 [1958574.001]
  • [Cites] Toxicol Lett. 2005 Dec 15;159(3):203-11 [16188404.001]
  • [Cites] Endocrinology. 1993 Oct;133(4):1817-22 [8404624.001]
  • [Cites] Arch Toxicol. 1998 May;72(6):372-80 [9657285.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2687-92 [9122257.001]
  • [Cites] Neurosurgery. 1995 Sep;37(3):496-503; discussion 503-4 [7501116.001]
  • [Cites] Clin Chim Acta. 2003 Feb;328(1-2):121-8 [12559607.001]
  • [Cites] Ann Clin Biochem. 1998 Sep;35 ( Pt 5):637-42 [9768330.001]
  • [Cites] Proc Natl Acad Sci U S A. 1977 Nov;74(11):4816-20 [200933.001]
  • [Cites] Neuroendocrinology. 2007;86(2):84-93 [17684316.001]
  • [Cites] Horm Metab Res. 2006 Apr;38(4):246-52 [16700006.001]
  • [Cites] J Chem Neuroanat. 2007 Sep;34(1-2):22-8 [17467234.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Nov;87(11):5325-31 [12414909.001]
  • [Cites] J Steroid Biochem. 1982 Feb;16(2):165-9 [7078155.001]
  • [Cites] J Steroid Biochem Mol Biol. 1992 Aug;42(7):757-71 [1504013.001]
  • [Cites] J Clin Endocrinol Metab. 1984 Jan;58(1):6-11 [6689683.001]
  • [Cites] J Mol Model. 2003 Jun;9(3):183-9 [12733052.001]
  • [Cites] Neuroendocrinology. 2003 Aug;78(2):61-71 [12915758.001]
  • [Cites] Biochim Biophys Acta. 1976 Jan 14;421(1):115-23 [174733.001]
  • [Cites] J Immunol. 1999 Aug 15;163(4):2113-9 [10438951.001]
  • [Cites] J Clin Endocrinol Metab. 1997 Nov;82(11):3758-62 [9360537.001]
  • [Cites] J Neurosurg. 1990 Nov;73(5):736-42 [2134312.001]
  • [Cites] Cell. 1995 Dec 15;83(6):851-7 [8521509.001]
  • (PMID = 19172388.001).
  • [ISSN] 1573-6830
  • [Journal-full-title] Cellular and molecular neurobiology
  • [ISO-abbreviation] Cell. Mol. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Insulin; 0 / NR3C1 protein, human; 0 / Receptors, Glucocorticoid; 7S5I7G3JQL / Dexamethasone; 9010-38-2 / Transcortin; WI4X0X7BPJ / Hydrocortisone
  •  go-up   go-down


39. Capper D, Zentgraf H, Balss J, Hartmann C, von Deimling A: Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol; 2009 Nov;118(5):599-601
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors.
  • Here, we show the high specificity and sensitivity of this antibody on Western blots and tissue sections from formalin fixed paraffin embedded tumor specimens.
  • This antibody is highly useful for tumor classification, in detecting single infiltrating tumor cells and for the characterization of the cellular role of mutant IDH1 protein.
  • [MeSH-minor] Animals. Arginine / genetics. Astrocytoma / metabolism. Brain Neoplasms / metabolism. Histidine / genetics. Humans. Mice. Oligodendroglioma / metabolism. Sensitivity and Specificity


40. Doherty MJ, Hampson NB: Partial seizure provoked by hyperbaric oxygen therapy: possible mechanisms and implications. Epilepsia; 2005 Jun;46(6):974-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a patient after resection of anaplastic astrocytoma and 5,580 cGy of total external-beam radiation treatments with brain radiation necrosis who underwent HBO2 therapy and developed a partial seizure during treatment.
  • [MeSH-minor] Astrocytoma / radiotherapy. Astrocytoma / surgery. Brain Neoplasms / radiotherapy. Brain Neoplasms / surgery. Combined Modality Therapy. Humans. Male. Middle Aged. Necrosis / etiology. Necrosis / pathology. Necrosis / therapy. Radiotherapy, Conformal / adverse effects

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15946345.001).
  • [ISSN] 0013-9580
  • [Journal-full-title] Epilepsia
  • [ISO-abbreviation] Epilepsia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


41. Chen AY, Lee H, Hartman J, Greco C, Ryu JK, O'Donnell R, Boggan J: Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma. AJNR Am J Neuroradiol; 2005 Jan;26(1):160-2
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma.
  • We report a case of a supratentorial primitive neuroectodermal tumor (PNET) that occurred 12 years after cranial irradiation for a grade II astrocytoma.
  • Neuroimaging was unable to distinguish between a recurrence of the original neoplasm and the development of a new, distinct entity.
  • [MeSH-major] Astrocytoma / radiotherapy. Brain Neoplasms / radiotherapy. Cranial Irradiation. Frontal Lobe. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Second Primary / diagnosis. Neuroectodermal Tumors, Primitive / diagnosis. Supratentorial Neoplasms / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Humans. Radiotherapy, Adjuvant. Synaptophysin / analysis


42. Adamson DC, Rasheed BA, McLendon RE, Bigner DD: Central nervous system. Cancer Biomark; 2010;9(1-6):193-210
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The prognoses for these tumors are related to several factors, such as the age of the patient and the location and histology of the tumor.
  • Arising from glial cells, gliomas represent over 36% of all primary CNS tumors and consist of astrocytomas, oligodendrogliomas, ependymomas, mixed gliomas, and neuroepithelial tumors.
  • The most common gliomas are astrocytomas, and these tumors are typically classified by the World Health Organization (WHO) as Grades I through IV.
  • Grade IV, the most malignant grade of astrocytoma, includes glioblastoma multiforme (GBM), the most common malignant primary CNS glioma in adults, which represents 51% of all CNS gliomas.
  • Here we describe the molecular and cellular events associated with malignant glioma initiation and progression.
  • We also review the importance of glioma stem cell biology and tumor immunology in early gliomagenesis.
  • In addition, we present a brief description of the most common malignant primary CNS glioma in pediatric patients - medulloblastoma, as well as familial cancer syndromes that include gliomas as part of the syndrome.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 22112477.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  •  go-up   go-down


43. Shin JH, Kim SW, Lim CM, Jeong JY, Piao CS, Lee JK: alphaB-crystallin suppresses oxidative stress-induced astrocyte apoptosis by inhibiting caspase-3 activation. Neurosci Res; 2009 Aug;64(4):355-61
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To investigate the functional significance of alphaB-crystallin induction in astrocytes, we generated a stable C6 astroglioma cell line overexpressing alphaB-crystallin.
  • Furthermore, the repression of alphaB-crystallin expression by alphaB-crystallin siRNA transfection suppressed this protective effect, indicating that alphaB-crystallin is responsible for the protection against H2O2-induced apoptosis in C6 astroglioma cells.
  • [MeSH-minor] Animals. Cell Line, Tumor. Cytoprotection / physiology. Down-Regulation / physiology. Hydrogen Peroxide / toxicity. Neurodegenerative Diseases / genetics. Neurodegenerative Diseases / metabolism. Neurodegenerative Diseases / physiopathology. Oxidants / toxicity. Protein Binding / physiology. RNA Interference / physiology. Rats. Transfection

  • Hazardous Substances Data Bank. HYDROGEN PEROXIDE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19379782.001).
  • [ISSN] 1872-8111
  • [Journal-full-title] Neuroscience research
  • [ISO-abbreviation] Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Oxidants; 0 / alpha-Crystallin B Chain; BBX060AN9V / Hydrogen Peroxide; EC 3.4.22.- / Caspase 3
  •  go-up   go-down


44. Yang SH, Hong YK, Yoon SC, Kim BS, Lee YS, Lee TK, Lee KS, Jeun SS, Kim MC, Park CK: Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant glioma. Oncol Rep; 2007 Jun;17(6):1359-64
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant glioma.
  • We analyzed the clinical efficacy and toxicity of concurrent therapy as a first line modality for malignant glioma patients.
  • From 1998 to 2004, 39 patients, 22 with glioblastoma (GM), nine with anaplastic astrocytoma (AA), 7 with anaplastic oligodendroglioma (AO) and 1 with anaplastic oligodendro-astrocytoma (AOA) were enrolled in this study.
  • Modified concurrent chemoradiotherapy may be a feasible option for treating malignant glioma with acceptable toxicity.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Brain Neoplasms / drug therapy. Glioma / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Disease Progression. Disease-Free Survival. Female. Humans. Lomustine / administration & dosage. Lomustine / adverse effects. Male. Middle Aged. Procarbazine / administration & dosage. Procarbazine / adverse effects. Survival Analysis. Treatment Outcome. Vincristine / administration & dosage. Vincristine / adverse effects

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • Hazardous Substances Data Bank. LOMUSTINE .
  • Hazardous Substances Data Bank. VINCRISTINE .
  • Hazardous Substances Data Bank. PROCARBAZINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17487391.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine
  •  go-up   go-down


45. Hartmann C, Hentschel B, Wick W, Capper D, Felsberg J, Simon M, Westphal M, Schackert G, Meyermann R, Pietsch T, Reifenberger G, Weller M, Loeffler M, von Deimling A: Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol; 2010 Dec;120(6):707-18
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas.
  • WHO grading of human brain tumors extends beyond a strictly histological grading system by providing a basis predictive for the clinical behavior of the respective neoplasm.
  • For example, patients with glioblastoma WHO grade IV usually show a less favorable clinical course and receive more aggressive first-line treatment than patients with anaplastic astrocytoma WHO grade III.
  • Here we provide evidence that the IDH1 status is more prognostic for overall survival than standard histological criteria that differentiate high-grade astrocytomas.
  • We sequenced the isocitrate dehydrogenase 1 gene (IDH1) at codon 132 in 382 patients with anaplastic astrocytoma and glioblastoma from the NOA-04 trial and from a prospective translational cohort study of the German Glioma Network.
  • Patients with anaplastic astrocytomas carried IDH1 mutations in 60%, and patients with glioblastomas in 7.2%.
  • The sequence from more favorable to poorer outcome was (1) anaplastic astrocytoma with IDH1 mutation, (2) glioblastoma with IDH1 mutation, (3) anaplastic astrocytoma without IDH1 mutation and (4) glioblastoma without IDH1 mutation (p < 0.0001).
  • In this combined set of anaplastic astrocytomas and glioblastomas both, IDH1 mutation and IDH1 expression status were of greater prognostic relevance than histological diagnosis according to the current WHO classification system.
  • We propose to complement the current WHO classification and grading of high-grade astrocytic gliomas by the IDH1 mutation status and to use this combined histological and molecular classification in future clinical trials.
  • [MeSH-major] Brain Neoplasms / genetics. Glioblastoma / genetics. Glioma / classification. Glioma / genetics. Isocitrate Dehydrogenase / genetics. Mutation / genetics
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Astrocytoma / diagnosis. Astrocytoma / genetics. Astrocytoma / pathology. Cohort Studies. Female. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Young Adult


46. Okamoto H, Mineta T, Ueda S, Nakahara Y, Shiraishi T, Tamiya T, Tabuchi K: Detection of JC virus DNA sequences in brain tumors in pediatric patients. J Neurosurg; 2005 Apr;102(3 Suppl):294-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Genomic DNA sequences were isolated from 62 brain tumors (32 medulloblastomas, 18 ependymomas, five choroid plexus papillomas, and seven pilocytic astrocytomas) and analyzed for the presence of JC virus DNA by Southern blot hybridization and direct sequencing.
  • None of the medulloblastomas or pilocytic astrocytomas contained JC virus DNA.
  • [MeSH-minor] Antigens, Viral, Tumor / genetics. Astrocytoma / pathology. Astrocytoma / virology. Base Sequence. Blotting, Southern. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / virology. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / virology. Child. Child, Preschool. Ependymoma / pathology. Ependymoma / virology. Female. Humans. Infant. Male. Medulloblastoma / pathology. Medulloblastoma / virology. Papilloma, Choroid Plexus / pathology. Papilloma, Choroid Plexus / virology. Polymerase Chain Reaction. Supratentorial Neoplasms / pathology. Supratentorial Neoplasms / virology

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15881753.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
  •  go-up   go-down


47. Hulleman E, Helin K: Molecular mechanisms in gliomagenesis. Adv Cancer Res; 2005;94:1-27
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Glioma, and in particular high-grade astrocytoma termed glioblastoma multiforme (GBM), is the most common primary tumor of the brain.
  • Modeling of astrocytomas by genetic manipulation of mice suggests that deregulation of the pathways that control gliogenesis during normal brain development, such as the differentiation of neural stem cells (NSCs) into astrocytes, might contribute to GBM formation.
  • Use of novel techniques including large-scale genomics and proteomics in combination with relevant mouse models will most likely provide novel insights into the molecular mechanisms underlying glioma formation and will hopefully lead to development of treatment modalities for GBM.
  • [MeSH-major] Brain Neoplasms / classification. Brain Neoplasms / physiopathology. Glioma / classification. Signal Transduction / physiology

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16095998.001).
  • [ISSN] 0065-230X
  • [Journal-full-title] Advances in cancer research
  • [ISO-abbreviation] Adv. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 155
  •  go-up   go-down


48. Bartik P, Maglott A, Entlicher G, Vestweber D, Takeda K, Martin S, Dontenwill M: Detection of a hypersialylated beta1 integrin endogenously expressed in the human astrocytoma cell line A172. Int J Oncol; 2008 May;32(5):1021-31
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of a hypersialylated beta1 integrin endogenously expressed in the human astrocytoma cell line A172.
  • Gliomas are the most common deadly brain tumors.
  • As a potential new target, alpha5beta1 was investigated here in two human astrocytoma cell lines, A172 and U87MG.
  • Overexpression of the beta1 integrin subunit in A172 cells not only increased the hypersialylated form but also led to the appearance of a non-hypersialylated beta1 form also addressed to the cell surface.
  • [MeSH-major] Antigens, CD29 / metabolism. Astrocytoma / metabolism. Brain Neoplasms / metabolism. Protein Processing, Post-Translational. Sialic Acids / metabolism
  • [MeSH-minor] Cell Adhesion. Cell Line, Tumor. Cell Membrane / metabolism. Cell Proliferation. Dimerization. Fibronectins / metabolism. Glycosylation. Humans. Integrin alpha5 / metabolism. Integrin alpha5beta1 / antagonists & inhibitors. Integrin alpha5beta1 / metabolism. Propionates / pharmacology. Pyridines / pharmacology. Spiro Compounds / pharmacology. Transfection. Up-Regulation

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18425328.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Fibronectins; 0 / Integrin alpha5; 0 / Integrin alpha5beta1; 0 / Propionates; 0 / Pyridines; 0 / SJ749; 0 / Sialic Acids; 0 / Spiro Compounds
  •  go-up   go-down


49. Higgins SC, Pilkington GJ: The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant glioma. Anticancer Res; 2010 Feb;30(2):391-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant glioma.
  • BACKGROUND: In this investigation the effects of tricyclic drugs on cellular respiration were studied using the anaplastic astrocytoma cell line IPSB-18 by use of a Clark-type oxygen electrode which measured changes in cellular respiration rate (oxygen consumption), in a dose-response assay.
  • Overall, it appeared that clomipramine and its metabolite norclomipramine were the most potent inhibitors of cellular respiration in glioma cells over the concentration range 0.5-0.9 mM.
  • Dexamethasone was able to induce inhibition of cellular respiration both alone in glioma cells, and in combination with clomipramine, where it had an additive or synergistic effect, thereby increasing cell death.
  • CONCLUSION: The extensive research currently ongoing and previously reported regarding the use of clomipramine as a potential antineoplastic agent aimed at targeting the mitochondria of gliomas is promising.
  • [MeSH-major] Antidepressive Agents, Tricyclic / pharmacology. Antineoplastic Agents, Hormonal / pharmacology. Astrocytoma / metabolism. Brain Neoplasms / metabolism. Cell Respiration / drug effects. Dexamethasone / pharmacology
  • [MeSH-minor] Amitriptyline / pharmacology. Antineoplastic Combined Chemotherapy Protocols. Clomipramine / pharmacology. Doxepin / pharmacology. Humans. Oxygen Consumption / drug effects. Respiratory Rate. Tumor Cells, Cultured

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. DOXEPIN .
  • Hazardous Substances Data Bank. Clomipramine .
  • Hazardous Substances Data Bank. DEXAMETHASONE .
  • Hazardous Substances Data Bank. AMITRIPTYLINE HYDROCHLORIDE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20332444.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antidepressive Agents, Tricyclic; 0 / Antineoplastic Agents, Hormonal; 1668-19-5 / Doxepin; 1806D8D52K / Amitriptyline; 7S5I7G3JQL / Dexamethasone; NUV44L116D / Clomipramine
  •  go-up   go-down


50. Lee JM, Kim SH, Lee JI, Ryou JY, Kim SY: Acute comitant esotropia in a child with a cerebellar tumor. Korean J Ophthalmol; 2009 Sep;23(3):228-31
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute comitant esotropia in a child with a cerebellar tumor.
  • We report a case of acute comitant esotropia in a child with a cerebellar tumor.
  • A 3-year-old boy was referred for management of a 9 month history of acute acquired comitant esotropia.
  • The mass was completely excised and histological examination confirmed the diagnosis of pilocytic astrocytoma.
  • Therefore, acute onset comitant esotropia in a child can be the first sign of a cerebellar tumor, even without any other neurological signs and symptoms.
  • [MeSH-major] Astrocytoma / complications. Cerebellar Neoplasms / complications. Esotropia / etiology
  • [MeSH-minor] Acute Disease. Brain / pathology. Child, Preschool. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Oculomotor Muscles / surgery. Refraction, Ocular. Time Factors

  • Genetic Alliance. consumer health - Esotropia.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Dev Med Child Neurol. 1987 Apr;29(2):207-11 [3582790.001]
  • [Cites] Trans New Orleans Acad Ophthalmol. 1986;34:449-60 [3726963.001]
  • [Cites] Arch Ophthalmol. 1989 Mar;107(3):376-8 [2923560.001]
  • [Cites] Can J Ophthalmol. 1994 Jun;29(3):151-4 [7922858.001]
  • [Cites] Br J Ophthalmol. 1995 May;79(5):498-501 [7612566.001]
  • [Cites] Am J Ophthalmol. 1996 May;121(5):584-6 [8610811.001]
  • [Cites] J Neuroophthalmol. 1996 Mar;16(1):49-54 [8963421.001]
  • [Cites] Strabismus. 2004 Jun;12(2):119-23 [15672935.001]
  • [Cites] Graefes Arch Clin Exp Ophthalmol. 1988;226(2):172-4 [3282996.001]
  • [Cites] J AAPOS. 1997 Sep;1(3):143-6 [10532775.001]
  • [Cites] Eye (Lond). 1999 Oct;13 ( Pt 5):617-20 [10696312.001]
  • [Cites] Int Ophthalmol. 1999;23(3):167-70 [11456255.001]
  • [Cites] Am J Ophthalmol. 1970 Apr;69(4):594-8 [5309572.001]
  • [Cites] Trans Am Ophthalmol Soc. 1970;68:730-822 [5524219.001]
  • [Cites] Br J Ophthalmol. 1972 Oct;56(10):776-82 [4679659.001]
  • [Cites] J Pediatr Ophthalmol Strabismus. 1981 May-Jun;18(3):29-34 [7264848.001]
  • [Cites] J Pediatr Ophthalmol Strabismus. 1987 Mar-Apr;24(2):83-6 [3585657.001]
  • (PMID = 19794955.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2739968
  • [Keywords] NOTNLM ; Acute onset / Cerebellar tumor / Comitant esotropia
  •  go-up   go-down


51. Jin M, Komohara Y, Shichijo S, Yamanaka R, Nikawa J, Itoh K, Yamada A: Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients. Cancer Sci; 2008 Aug;99(8):1656-62
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients.
  • In the present study, we examined the expression of the EphB6 variant (EphB6v) in a panel of brain tumor cell lines and glioblastoma tissues and we found that EphB6v was preferentially expressed in malignant brain tumors, such as glioblastomas and anaplastic astrocytomas.
  • The two EphB6v-derived peptides exhibited the ability to bind to human leukocyte antigen (HLA)-A0201 molecules, and each of them was able to induce cytotoxic T lymphocytes in vitro in the peripheral blood mononuclear cells of HLA-A2(+) glioma patients.
  • [MeSH-minor] Astrocytoma / metabolism. Brain Neoplasms / metabolism. Case-Control Studies. Cell Line, Tumor. Gene Expression. Glioblastoma / metabolism. HLA-A Antigens. HLA-A2 Antigen. Hepatocytes. Humans

  • Genetic Alliance. consumer health - Glioma.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18754880.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HLA-A Antigens; 0 / HLA-A*02:01 antigen; 0 / HLA-A2 Antigen; EC 2.7.1.- / EPHB6 protein, human; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
  •  go-up   go-down


52. Spacca B, Mallucci C, Riordan A, Appleton R, Thorp N, Pizer B: HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature. Childs Nerv Syst; 2007 Nov;23(11):1347-50
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature.
  • CASE REPORT: A 13-year-old boy was diagnosed with an inoperable, biopsy-proven pontine grade II astrocytoma.
  • He made slow improvement but died 8 months after diagnosis from tumor progression.
  • [MeSH-major] Astrocytoma / complications. Brain Stem Neoplasms / complications. Encephalitis, Herpes Simplex / etiology. Herpesvirus 1, Human. Radiotherapy / adverse effects

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Radiation Therapy.
  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for brain stem glioma .
  • Hazardous Substances Data Bank. ACYCLOVIR .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Neurosurg. 1972 Apr;36(4):499-502 [4335254.001]
  • [Cites] Hum Pathol. 1998 Mar;29(3):215-22 [9496822.001]
  • [Cites] Childs Nerv Syst. 1997 Jun;13(6):352-5 [9272290.001]
  • [Cites] Clin Infect Dis. 2003 May 15;36(10):1335-9 [12746782.001]
  • [Cites] J Neurol Neurosurg Psychiatry. 1999 Aug;67(2):239-42 [10407001.001]
  • [Cites] Herpes. 2004 Jun;11 Suppl 2:48A-56A [15319090.001]
  • [Cites] J Clin Microbiol. 1998 Aug;36(8):2229-34 [9665997.001]
  • [Cites] Antiviral Res. 2006 Sep;71(2-3):141-8 [16675036.001]
  • [Cites] J Virol. 1999 Dec;73(12):10514-8 [10559370.001]
  • [Cites] Neuroradiology. 1996 Jan;38(1):73-9 [8773284.001]
  • [Cites] Pediatr Neurol. 2003 Jul;29(1):69-71 [13679127.001]
  • [Cites] N Engl J Med. 1986 Jan 16;314(3):144-9 [3001520.001]
  • [Cites] Neurosurgery. 1999 Mar;44(3):633-5; discussion 635-6 [10069600.001]
  • [Cites] Herpes. 2004 Jun;11 Suppl 2:57A-64A [15319091.001]
  • (PMID = 17593375.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antiviral Agents; X4HES1O11F / Acyclovir
  • [Number-of-references] 14
  •  go-up   go-down


53. Darendeliler F, Karagiannis G, Wilton P, Ranke MB, Albertsson-Wikland K, Anthony Price D, On Behalf Of The Kigs International Board: Recurrence of brain tumours in patients treated with growth hormone: analysis of KIGS (Pfizer International Growth Database). Acta Paediatr; 2006 Oct;95(10):1284-90
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of brain tumours in patients treated with growth hormone: analysis of KIGS (Pfizer International Growth Database).
  • AIM: To analyse KIGS (Pfizer International Growth Database) with respect to tumour recurrence in patients with brain tumours.
  • METHODS: Data for tumour recurrence were analysed retrospectively in 1038 patients with craniopharyngiomas, 655 with medulloblastomas, 113 with ependymomas, 297 with germinomas, and 400 with astrocytomas or gliomas.
  • [MeSH-major] Brain Neoplasms / drug therapy. Human Growth Hormone / therapeutic use. Neoplasm Recurrence, Local / epidemiology. Recombinant Proteins / therapeutic use
  • [MeSH-minor] Adolescent. Astrocytoma / drug therapy. Astrocytoma / mortality. Astrocytoma / radiotherapy. Astrocytoma / surgery. Child. Child, Preschool. Combined Modality Therapy. Craniopharyngioma / drug therapy. Craniopharyngioma / mortality. Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery. Disease-Free Survival. Ependymoma / drug therapy. Ependymoma / mortality. Ependymoma / radiotherapy. Ependymoma / surgery. Female. Germinoma / drug therapy. Germinoma / mortality. Germinoma / radiotherapy. Germinoma / surgery. Humans. Male. Medulloblastoma / drug therapy. Medulloblastoma / mortality. Medulloblastoma / radiotherapy. Medulloblastoma / surgery

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16982503.001).
  • [ISSN] 0803-5253
  • [Journal-full-title] Acta paediatrica (Oslo, Norway : 1992)
  • [ISO-abbreviation] Acta Paediatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone
  •  go-up   go-down


54. Jaing TH, Lin KL, Tsay PK, Hsueh C, Hung PC, Wu CT, Tseng CK: Treatment of optic pathway hypothalamic gliomas in childhood: experience with 18 consecutive cases. J Pediatr Hematol Oncol; 2008 Mar;30(3):222-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of optic pathway hypothalamic gliomas in childhood: experience with 18 consecutive cases.
  • The aim of this study was to present our 17-year experience (1989 to 2006) in the treatment of optic pathway/hypothalamic gliomas (OPHG) in 18 children younger than 17 years (median age, 66 mo).
  • Histologic studies showed low-grade astrocytoma (WHO grade I or II) in 16 cases, anaplastic astrocytoma in 1, and oligoastrocytoma (WHO grade III) in 1.
  • Treatment included partial tumor resection in 12 patients, chemotherapy in 5, and radiotherapy in 3.
  • All treatment modalities led to tumor shrinkage and stabilization for a variable period, but none of them totally eradicated the tumor.
  • Fourteen (78%) of 18 patients had a sustained reduction of tumor size between 6 months and 17 years.
  • Two patients died, none with neurofibromatosis-1, with a hypothalamic/chiasmatic tumor with suprasellar extension and accompanying electrolyte abnormalities.
  • Because progression of these tumors is slow and associated with endocrinopathy, we recommend chemotherapy as a primary treatment of OPHG if the disease progresses.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hypothalamic Neoplasms / therapy. Optic Nerve Glioma / therapy. Visual Pathways / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Predictive Value of Tests. Retrospective Studies. Survival Rate. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18376285.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


55. Mamedova L, Capra V, Accomazzo MR, Gao ZG, Ferrario S, Fumagalli M, Abbracchio MP, Rovati GE, Jacobson KA: CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem Pharmacol; 2005 Dec 19;71(1-2):115-25
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 1321N1 astrocytoma cells stably expressing human P2Y(1,2,4,6) receptors, CysLT1 antagonists inhibited both the P2Y agonist-induced activation of phospholipase C and intracellular Ca2+ mobilization.
  • In control astrocytoma cells expressing an endogenous M3 muscarinic receptor, 10 microM montelukast had no effect on the carbachol-induced rise in intracellular Ca2+.

  • COS Scholar Universe. author profiles.
  • Guide to Pharmacology. gene/protein/disease-specific - P2Y6 receptor - data and references .
  • Hazardous Substances Data Bank. MONTELUKAST .
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16280122.001).
  • [ISSN] 0006-2952
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DK031116-21
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acetates; 0 / Chromones; 0 / DNA Primers; 0 / Membrane Proteins; 0 / Quinolines; 0 / Receptors, Leukotriene; 0 / Receptors, Purinergic P2; 0 / leukotriene D4 receptor; 0 / pranlukast; MHM278SD3E / montelukast; SY7Q814VUP / Calcium; UT0S826Z60 / Uridine Triphosphate
  • [Other-IDs] NLM/ NIHMS31385; NLM/ PMC4967539
  •  go-up   go-down


56. McNatt SA, Gonzalez-Gomez I, Nelson MD, McComb JG: Synchronous multicentric pleomorphic xanthoastrocytoma: case report. Neurosurgery; 2005 Jul;57(1):E191; discussion E191
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE AND IMPORTANCE: Pleomorphic xanthoastrocytoma (PXA) is a rare, low-grade astrocytoma of adolescence.
  • INTERVENTION: A right frontal craniotomy was performed for excisional biopsy of a superficial lesion beneath the coronal suture.
  • Three years after treatment, the patient remains neurologically nonfocal and shows no evidence of disease progression.
  • [MeSH-major] Astrocytoma. Brain Neoplasms. Neoplasms, Multiple Primary

  • Genetic Alliance. consumer health - Pleomorphic xanthoastrocytoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15987556.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


57. Harder T, Plagemann A, Harder A: Birth weight and subsequent risk of childhood primary brain tumors: a meta-analysis. Am J Epidemiol; 2008 Aug 15;168(4):366-73
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Previous studies have suggested that high birth weight is associated with an increased brain tumor risk.
  • The authors identified eight studies involving 1,748,964 children, of whom 4,162 suffered from brain tumors of three histologic types (astrocytoma, medulloblastoma, and ependymoma).
  • For astrocytoma, high birth weight (>4,000 g) was associated with increased risk (odds ratio = 1.38, 95% confidence interval (CI): 1.07, 1.79), with each 1,000-g increase in birth weight being associated with a 19% (95% CI: 4, 36) increase in risk.
  • [MeSH-major] Astrocytoma / epidemiology. Birth Weight. Brain Neoplasms / epidemiology. Ependymoma / epidemiology. Fetal Macrosomia / epidemiology. Medulloblastoma / epidemiology

  • MedlinePlus Health Information. consumer health - Birth Weight.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18579539.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 67763-96-6 / Insulin-Like Growth Factor I
  •  go-up   go-down


58. Durmaz R, Vural M, Işildi E, Coşan E, Ozkara E, Bal C, Ciftçi E, Arslantaş A, Atasoy MA: Efficacy of prognostic factors on survival in patients with low grade glioma. Turk Neurosurg; 2008 Oct;18(4):336-44
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of prognostic factors on survival in patients with low grade glioma.
  • AIM: In this report, we aim to determine the prognostic factors influencing the length of survival in patients with low-grade gliomas.
  • The diagnoses of the patients were histopathologically verified as low-grade glioma(LGG).
  • The medical records of the patients were reviewed for age, gender, tumor locations, extent of resection, and presence of seizure, the neurological status as defined by the Karnofsky Performance Scale (KPS) and radiotherapy treatment after surgery as possible prognostic factors.
  • Median survival time was 216+/-78.52 months for astrocytoma Grade I; 115+/-8.22 months for astrocytoma Grade II, and 242+/-76.36 months for oligodendroglioma.
  • Young age, histology subtype (oligodendroglioma) and preoperative KPS were determined to have positive influence on survival according to Log Rank Test.
  • [MeSH-major] Brain Neoplasms / mortality. Brain Neoplasms / pathology. Glioma / mortality. Glioma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aging. Astrocytoma / mortality. Astrocytoma / pathology. Astrocytoma / surgery. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Karnofsky Performance Status. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Oligodendroglioma / mortality. Oligodendroglioma / pathology. Oligodendroglioma / surgery. Prognosis. Reoperation. Retrospective Studies. Seizures / etiology. Survival. Tomography, X-Ray Computed. Young Adult


59. Stark AM, Fritsch MJ, Claviez A, Dörner L, Mehdorn HM: Management of tectal glioma in childhood. Pediatr Neurol; 2005 Jul;33(1):33-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of tectal glioma in childhood.
  • Tectal glioma is a topographical diagnosis including tumors of different histology, mainly low-grade astrocytomas.
  • This report discusses the management of this rare tumor in children.
  • Clinical charts of 12 children with tectal glioma treated in our department between 1976 and 2001 were retrospectively reviewed.
  • The duration between first symptoms and the diagnosis of tectal glioma was in the range of 2 days to 9 years.
  • Ten patients presented with symptoms associated with increased intracranial pressure, one patient presented with ataxia, and in one case tectal glioma was an incidental finding.
  • First-line therapy was endoscopic third ventriculostomy in 5 cases (42%), ventriculoperitoneal shunting in 6 cases (50%), and combined partial tumor resection and shunting in one case.
  • Histology was obtained in 5 cases (low-grade astrocytoma, n = 4; ependymoma, n = 1).
  • Tectal glioma represents a distinct subgroup of brainstem tumors associated with a good (or favorable) prognosis.
  • Effective treatment for hydrocephalus is essential; the tumor should be monitored by regular clinical examination and magnetic resonance imaging.
  • Biopsy is warranted in cases with tumor progression.
  • [MeSH-major] Brain Neoplasms / pathology. Brain Neoplasms / therapy. Glioma / pathology. Glioma / therapy. Superior Colliculi / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Management. Female. Follow-Up Studies. Humans. Infant. Male. Retrospective Studies

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15876519.001).
  • [ISSN] 0887-8994
  • [Journal-full-title] Pediatric neurology
  • [ISO-abbreviation] Pediatr. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


60. Shimizu H, Mori O, Ohaki Y, Kamoi S, Kobayashi S, Okada S, Maeda S, Naito Z: Cytological interface of diffusely infiltrating astrocytoma and its marginal tissue. Brain Tumor Pathol; 2005;22(2):59-74
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytological interface of diffusely infiltrating astrocytoma and its marginal tissue.
  • Cytological differences between infiltrating lesions of the diffusely infiltrating astrocytoma (DIA) and reactive gliosis at its periphery have not yet been established.
  • The cytological findings of this area are important because the surgeon may have to make a rapid diagnosis regarding the existence of the tumor.
  • [MeSH-major] Astrocytoma / pathology. Brain / pathology. Brain Neoplasms / pathology. Glioblastoma / pathology. Gliosis / pathology
  • [MeSH-minor] Adult. Astrocytes / ultrastructure. Axons / ultrastructure. Biopsy. Carcinoma / secondary. Cell Nucleus / ultrastructure. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Myelin Sheath / ultrastructure. Neoplasm Invasiveness. Neurons / ultrastructure. Oligodendroglia / ultrastructure. Staining and Labeling / methods

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18095107.001).
  • [ISSN] 1861-387X
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


61. Server A, Kulle B, Maehlen J, Josefsen R, Schellhorn T, Kumar T, Langberg CW, Nakstad PH: Quantitative apparent diffusion coefficients in the characterization of brain tumors and associated peritumoral edema. Acta Radiol; 2009 Jul;50(6):682-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Conventional magnetic resonance (MR) imaging has a number of limitations in the diagnosis of the most common intracranial brain tumors, including tumor specification and the detection of tumoral infiltration in regions of peritumoral edema.
  • PURPOSE: To prospectively assess if diffusion-weighted MR imaging (DWI) could be used to differentiate between different types of brain tumors and to distinguish between peritumoral infiltration in high-grade gliomas, lymphomas, and pure vasogenic edema in metastases and meningiomas.
  • MATERIAL AND METHODS: MR imaging and DWI was performed on 93 patients with newly diagnosed brain tumors: 59 patients had histologically verified high-grade gliomas (37 glioblastomas multiforme, 22 anaplastic astrocytomas), 23 patients had metastatic brain tumors, five patients had primary cerebral lymphomas, and six patients had meningiomas.
  • Apparent diffusion coefficient (ADC) values of tumor (enhancing regions or the solid portion of tumor) and peritumoral edema, and ADC ratios (ADC of tumor or peritumoral edema to ADC of contralateral white matter, ADC of tumor to ADC of peritumoral edema) were compared with the histologic diagnosis.
  • ADC values and ratios of high-grade gliomas, primary cerebral lymphomas, metastases, and meningiomas were compared by using ANOVA and multiple comparisons.
  • Optimal thresholds of ADC values and ADC ratios for distinguishing high-grade gliomas from metastases were determined by receiver operating characteristic (ROC) curve analysis.
  • RESULTS: Statistically significant differences were found for minimum and mean of ADC tumor and ADC tumor ratio values between metastases and high-grade gliomas when including only one factor at a time.
  • Including a combination of in total four parameters (mean ADC tumor, and minimum, maximum and mean ADC tumor ratio) resulted in sensitivity, specificity, positive (PPV), and negative predictive values (NPV) of 72.9, 82.6, 91.5, and 54.3% respectively.
  • CONCLUSION: Our results suggest that ADC values and ADC ratios (minimum and mean of ADC tumor and ADC tumor ratio) may be helpful in the differentiation of metastases from high-grade gliomas.
  • It cannot distinguish high-grade gliomas from lymphomas, and lymphomas from metastases.
  • ADC values and ADC ratios in peritumoral edema cannot be used to differentiate edema with infiltration of tumor cells from vasogenic edema when measurements for high-grade gliomas, lymphomas, metastases, and meningiomas were compared.
  • [MeSH-major] Brain Edema / pathology. Brain Neoplasms / pathology. Glioma / pathology. Lymphoma / pathology. Meningioma / pathology

  • Genetic Alliance. consumer health - Edema.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Lymphoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19449234.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  •  go-up   go-down


62. Yang X, Cao W, Lin H, Zhang W, Lin W, Cao L, Zhen H, Huo J, Zhang X: Isoform-specific expression of 14-3-3 proteins in human astrocytoma. J Neurol Sci; 2009 Jan 15;276(1-2):54-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isoform-specific expression of 14-3-3 proteins in human astrocytoma.
  • In the present study, the levels of all seven 14-3-3 isoforms were examined in astrocytoma.
  • METHODS: The expression of 14-3-3 isoforms and their protein expression levels were examined in five glioma cell lines by western blotting.
  • Then in astrocytoma tissues, we investigated expression percentages of each isoform by immunohistochemistry.
  • RESULTS: 14-3-3beta and eta were specifically expressed in astrocytoma, and their expression frequencies and levels increased with the increase of astrocytoma malignancy.
  • The result from glioma cell lines was consistent with that from astrocytoma tissue.
  • CONCLUSIONS: In our study, we found two tumor-specific isoforms of 14-3-3 in astrocytoma.
  • They might be involved in astrocytoma tumorigenesis and may be useful as targets for therapy.
  • [MeSH-major] 14-3-3 Proteins / metabolism. Astrocytoma / metabolism

  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18851859.001).
  • [ISSN] 0022-510X
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Protein Isoforms; 0 / RNA, Messenger
  •  go-up   go-down


63. Amin A, Monabati A, Kumar PV, Hashemi SB: Nasal glioma (neuroglial heterotopia) mimicking an astrocytoma: case report. Ear Nose Throat J; 2005 Oct;84(10):657-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal glioma (neuroglial heterotopia) mimicking an astrocytoma: case report.
  • Nasal glioma is a rare benign tumor that usually occurs during infancy.
  • We report a case of nasal glioma in a 6-month-old boy in which the histomorphologic features resembled those of an anaplastic astrocytoma.
  • [MeSH-major] Astrocytoma / diagnosis. Glioma / diagnosis. Neuroglia / pathology. Nose Neoplasms / diagnosis

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Nasal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16382748.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


64. Pan JW, Zhan RY, Tong Y, Zhou YQ, Zhang M: Expression of endothelial nitric oxide synthase and vascular endothelial growth factor in association with neovascularization in human primary astrocytoma. J Zhejiang Univ Sci B; 2005 Jul;6(7):693-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of endothelial nitric oxide synthase and vascular endothelial growth factor in association with neovascularization in human primary astrocytoma.
  • OBJECTIVE: To investigate the relationship between the expression of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and angiogenesis in primary astrocytoma.
  • METHODS: Thirty-seven primary astrocytomas and 4 astrocytic hyperplasia samples were collected and divided into three groups according to histological grade.
  • The intensity of immunoreactivity was graded according to the percentage of positive tumor cells.
  • RESULTS: No eNOS and VEGF were expressed in the astrocytes and vascular endothelium in astrocytic hyperplasia.
  • The expression of eNOS or VEGF was light in low-grade astrocytoma and strong in glioblastoma. eNOS expression in astrocytoma was very positively correlated with VEGF. eNOS and VEGF expression in anaplastic astrocytoma was median in contrast to the low grade astrocytoma and glioblastoma.
  • Lower microvascular density was found in low grade astrocytoma than that in higher grade malignant ones.
  • The expressions of eNOS and VEGF were correlated with microvascular density and tumor malignancy.
  • CONCLUSION: This finding suggests that eNOS and VEGF may have cooperative effect in tumor angiogenesis and play an important role in the pathogenesis of primary astrocytoma.
  • [MeSH-major] Astrocytoma / blood supply. Astrocytoma / metabolism. Biomarkers, Tumor / metabolism. Neovascularization, Pathologic / metabolism. Vascular Endothelial Growth Factor A / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Blood. 2000 Jan 1;95(1):189-97 [10607702.001]
  • [Cites] Cardiovasc Res. 1999 Mar;41(3):773-80 [10435050.001]
  • [Cites] Circ Res. 2000 Apr 28;86(8):892-6 [10785512.001]
  • [Cites] Anal Quant Cytol Histol. 2000 Jun;22(3):267-74 [10872046.001]
  • [Cites] Br J Neurosurg. 2000 Dec;14(6):543-8 [11272032.001]
  • [Cites] Cardiovasc Res. 2001 Feb 16;49(3):568-81 [11166270.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2604-9 [11226286.001]
  • [Cites] J Neurooncol. 2000 Oct-Nov;50(1-2):139-48 [11245273.001]
  • [Cites] Int J Cancer. 2001 Mar 1;91(5):607-11 [11267968.001]
  • [Cites] Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L278-90 [11404271.001]
  • [Cites] Leukemia. 2001 Sep;15(9):1433-41 [11516104.001]
  • [Cites] Ann Anat. 2003 Dec;185(6):549-54 [14704000.001]
  • [Cites] J Clin Invest. 1998 Jun 1;101(11):2567-78 [9616228.001]
  • [Cites] Acta Neuropathol. 1998 Nov;96(5):453-62 [9829808.001]
  • [Cites] Nature. 1999 Jun 10;399(6736):597-601 [10376602.001]
  • [Cites] Neurosurgery. 1999 Jul;45(1):24-8; discussion 29 [10414562.001]
  • [Cites] Anticancer Res. 2000 Jan-Feb;20(1A):299-304 [10769671.001]
  • (PMID = 15973775.001).
  • [ISSN] 1673-1581
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vascular Endothelial Growth Factor A
  • [Other-IDs] NLM/ PMC1389807
  •  go-up   go-down


65. Nafe R, Schlote W, Schneider B: Histomorphometry of tumour cell nuclei in astrocytomas using shape analysis, densitometry and topometric analysis. Neuropathol Appl Neurobiol; 2005 Feb;31(1):34-44
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histomorphometry of tumour cell nuclei in astrocytomas using shape analysis, densitometry and topometric analysis.
  • Although tumour cell nuclei are important histological structures for grading of astrocytomas according to the WHO-classification of brain tumours, there is no reported morphometric study of astrocytomas which describes quantitatively the four main morphologic criteria of tumour cell nuclei: size, shape, texture (densitometric characteristics) and spatial relationships between the nuclei (topometric analysis).
  • Using a set of morphometric parameters describing these criteria as well as the Ki67-proliferation index, 74 astrocytomas from 74 patients were studied by means of a digital image analysis system.
  • The objective of the study was to test, if these morphometric parameters were sufficient for statistical discrimination between pilocytic astrocytomas WHO-grade I, astrocytomas grade II and anaplastic astrocytomas grade III.
  • In conclusion, the present morphometric procedure provided good discrimination between the tumour grades, supporting the view that histomorphometry of tumour cell nuclei could be a valuable tool for grading of astrocytomas.
  • [MeSH-major] Astrocytoma / pathology. Astrocytoma / ultrastructure. Brain Neoplasms / pathology. Brain Neoplasms / ultrastructure. Cell Nucleus / pathology. Cell Nucleus / ultrastructure

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15634229.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


66. Hashiba T, Izumoto S, Kagawa N, Suzuki T, Hashimoto N, Maruno M, Yoshimine T: Expression of WT1 protein and correlation with cellular proliferation in glial tumors. Neurol Med Chir (Tokyo); 2007 Apr;47(4):165-70; discussion 170
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The expression of Wilms' tumor gene WT1 protein was investigated immunohistochemically in 73 glial tumors, including 60 astrocytic tumors, eight oligodendroglial tumors, and five ependymal tumors.
  • Almost all glioblastomas, anaplastic astrocytomas, anaplastic ependymomas, and anaplastic oligodendrogliomas expressed high levels of WT1 protein.
  • Histological examination found that WT1 protein was strongly expressed in the anaplastic portions and areas with perivascular proliferation and high cellularity, implying that WT1 gene might be important in glial tumor cell proliferation.
  • [MeSH-major] Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Glioma / metabolism. Glioma / pathology. WT1 Proteins / metabolism

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17457020.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / WT1 Proteins
  •  go-up   go-down


67. Endale M, Kim SD, Lee WM, Kim S, Suk K, Cho JY, Park HJ, Wagley Y, Kim S, Oh JW, Rhee MH: Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes. Am J Physiol Cell Physiol; 2010 Mar;298(3):C611-23
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the role of ischemic stress in RGS2 protein expression in rat C6 astrocytoma cells and primary mouse astrocytes.
  • [MeSH-minor] Animals. Caspase 3 / metabolism. Cell Hypoxia. Cell Line, Tumor. Glucose / deficiency. Humans. Mice. Oxidative Stress. Phosphorylation. Protein Kinase C-delta / antagonists & inhibitors. Protein Kinase C-delta / genetics. Protein Kinase C-delta / metabolism. Protein Kinase Inhibitors / pharmacology. RNA Interference. RNA, Messenger / metabolism. Rats. Recombinant Fusion Proteins / metabolism. Signal Transduction. Time Factors. Transfection. Up-Regulation. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors. p38 Mitogen-Activated Protein Kinases / metabolism

  • Hazardous Substances Data Bank. GLUCOSE .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20032508.001).
  • [ISSN] 1522-1563
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / RGS Proteins; 0 / RGS2 protein, human; 0 / RGS2 protein, rat; 0 / RNA, Messenger; 0 / Recombinant Fusion Proteins; 0 / Rgs2 protein, mouse; EC 2.7.11.13 / Protein Kinase C-delta; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.4.22.- / Caspase 3; IY9XDZ35W2 / Glucose
  •  go-up   go-down


68. Narayana A, Bhatia S, Souweidane M, Khakoo Y, Zaider M: (32)P radioisotope therapy for recurrent pilocytic astrocytoma. Brachytherapy; 2005;4(2):171-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] (32)P radioisotope therapy for recurrent pilocytic astrocytoma.
  • Its effectiveness in the treatment of a selected brain tumor is illustrated here.
  • [MeSH-major] Astrocytoma / radiotherapy. Basal Ganglia / pathology. Brachytherapy / methods. Brain Neoplasms / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Phosphorus Radioisotopes / therapeutic use


69. Sakata H, Kanamori M, Watanabe M, Kumabe T, Tominaga T: Medulloblastoma demonstrating multipotent differentiation: case report. Brain Tumor Pathol; 2008;25(1):39-43
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • He underwent suboccipital craniotomy and total resection of the tumor.
  • Mature ganglion cells and melanotic tumor cells were also observed.
  • The diagnosis was medulloblastoma with myoblastic, neuronal, astrocytic, and melanotic differentiation.

  • Genetic Alliance. consumer health - Medulloblastoma.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18415665.001).
  • [ISSN] 1433-7398
  • [Journal-full-title] Brain tumor pathology
  • [ISO-abbreviation] Brain Tumor Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


70. Holland H, Koschny T, Ahnert P, Meixensberger J, Koschny R: WHO grade-specific comparative genomic hybridization pattern of astrocytoma - a meta-analysis. Pathol Res Pract; 2010 Oct 15;206(10):663-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] WHO grade-specific comparative genomic hybridization pattern of astrocytoma - a meta-analysis.
  • To detect novel genetic alterations, many astrocytomas have been investigated by comparative genomic hybridization (CGH).
  • To identify aberration profiles characteristic of World Health Organization (WHO) grade I, II, III, and IV astrocytoma, we performed a meta-analysis of detailed genome wide CGH data of all 467 cases published so far.
  • Low-grade astrocytoma has already demonstrated one characteristic of glioblastoma multiforme, gain of chromosome 7 with a hot spot at 7q32, but without loss of chromosome 10.
  • In anaplastic astrocytoma, a more complex aberration pattern emerges from diffuse genetic imbalances.
  • In contrast to lower tumor grades, glioblastoma multiforme demonstrates +7p12 as the most frequently affected band on chromosome 7.
  • To quantify the gradual transition from WHO grade II-IV astrocytoma, we calculated the relative increase and decrease in frequency for each detected aberration of the tumor genome.
  • The most pronounced and diverse changes of genetic material occur at the virtual transition from low-grade to anaplastic astrocytoma.
  • Summing up, the expansion of the CGH results to the 850 GTG-band resolution enabled a meta-analysis to visualize WHO grade-specific aberration profiles in astrocytoma.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Chromosome Aberrations. Comparative Genomic Hybridization. Glioblastoma / genetics. World Health Organization
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Genotype. Humans. Neoplasm Staging. Phenotype. Prognosis

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20570053.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Germany
  •  go-up   go-down


71. van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, Malmström PO, Collette L, Piérart M, Mirimanoff R, Karim AB, EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council: Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet; 2005 Sep 17-23;366(9490):985-90
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
  • BACKGROUND: Postoperative policies of "wait-and-see" and radiotherapy for low-grade glioma are poorly defined.
  • In 1986 the EORTC Radiotherapy and Brain Tumor Groups initiated a prospective trial to compare early radiotherapy with delayed radiotherapy.
  • Patients with low-grade astrocytoma, oligodendroglioma, mixed oligoastrocytoma, and incompletely resected pilocytic astrocytoma, with a WHO performance status 0-2 were eligible.
  • Radiotherapy could be deferred for patients with low-grade glioma who are in a good condition, provided they are carefully monitored.
  • [MeSH-major] Astrocytoma / radiotherapy. Central Nervous System Neoplasms / radiotherapy. Oligodendroglioma / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Disease-Free Survival. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Survival Rate

  • Genetic Alliance. consumer health - Oligodendroglioma.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Lancet Oncol. 2005 Dec;6(12):921; author reply 922 [16321759.001]
  • [ErratumIn] Lancet. 2006 Jun 3;367(9525):1818
  • (PMID = 16168780.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5U10 CA11488-; United States / NCI NIH HHS / CA / 5U10 CA11488-16
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  •  go-up   go-down


72. Johannessen AL, Torp SH: The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas. Pathol Oncol Res; 2006;12(3):143-7
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas.
  • The current WHO classification of human astrocytomas has limitations in predicting prognosis and diagnosis, and there is a need for additional factors.
  • Most of them demonstrate that MIB-1 LI differentiates well between diffuse astrocytomas WHO grade II (AII) and anaplastic astrocytomas (AA) and between AII and glioblastomas (GM), but not between AA and GM.
  • The studies reviewed report MIB-1 LI as an important prognostic factor in human astrocytomas.
  • Due to the great spread of values between the various tumor grades, however, MIB-1 LI cannot be used as a diagnostic factor alone but should be used in combination with established criteria of histological malignancy.
  • It may be especially useful in cases where histology reveals a low-grade astrocytoma whereas other parameters indicate a more malignant neoplasm.
  • Thus, it is our opinion that MIB-1 LI should be a part of the routine investigation in patients with astrocytic tumors.
  • [MeSH-major] Astrocytoma / metabolism. Astrocytoma / pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Ki-67 Antigen / metabolism

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Clin Neuropathol. 2004 Nov-Dec;23(6):262-70 [15584210.001]
  • [Cites] Int J Cancer. 1983 Jan 15;31(1):13-20 [6339421.001]
  • [Cites] J Neuropathol Exp Neurol. 1998 Oct;57(10):931-6 [9786243.001]
  • [Cites] Clin Neuropathol. 2002 Nov-Dec;21(6):252-7 [12489673.001]
  • [Cites] J Neurooncol. 1997 Aug;34(1):31-5 [9210051.001]
  • [Cites] J Exp Clin Cancer Res. 1997 Dec;16(4):389-94 [9505211.001]
  • [Cites] J Neuropathol Exp Neurol. 1997 Aug;56(8):857-65 [9258255.001]
  • [Cites] Pathol Res Pract. 2002;198(4):261-5 [12049334.001]
  • [Cites] Cancer. 1997 Dec 1;80(11):2133-40 [9392336.001]
  • [Cites] Pathol Oncol Res. 2001;7(4):267-78 [11882906.001]
  • [Cites] Am J Pathol. 1991 Apr;138(4):867-73 [2012175.001]
  • [Cites] J Neurooncol. 2001 Dec;55(3):195-204 [11859975.001]
  • [Cites] J Pathol. 1994 Dec;174(4):275-82 [7884589.001]
  • [Cites] Neurosurgery. 1998 Apr;42(4):724-9 [9574635.001]
  • [Cites] Neurochirurgie. 1998 Mar;44(1):25-30 [9757314.001]
  • [Cites] Lab Invest. 1993 Jun;68(6):629-36 [7685843.001]
  • [Cites] Acta Neuropathol. 1994;87(1):47-54 [7511316.001]
  • [Cites] J Neuropathol Exp Neurol. 1997 Jul;56(7):798-805 [9210876.001]
  • [Cites] Cancer. 1996 Jan 15;77(2):373-80 [8625247.001]
  • (PMID = 16998593.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Ki-67 Antigen; 0 / MIB-1 antibody
  • [Number-of-references] 20
  •  go-up   go-down


73. Li B, Qi XQ, Chen X, Huang X, Liu GY, Chen HR, Huang CG, Luo C, Lu YC: Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma. Brain Res; 2010 Sep 17;1352:200-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma.
  • However, the contribution of TPX2 expression to astrocytoma progression is unclear.
  • The aim of this study was to investigate TPX2 expression in human astrocytoma samples and cell lines.
  • TPX2 protein expression was detected in the nucleus of astrocytoma tissues by immunohistochemistry and immunofluorescence staining.
  • Real-time PCR and Western blot analysis showed that the expression levels of TPX2 were higher in high-grade astrocytoma tissues and cell lines than that in low-grade astrocytoma tissues and normal cell lines.
  • Immunohistochemical analysis of tumor tissues from 52 patients with astrocytoma showed that TPX2 over-expression was significantly associated with decreased patient survival.
  • These data suggest that TPX2 expression is associated with the progression of malignant astrocytoma.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Cell Cycle Proteins / genetics. Microtubule-Associated Proteins / genetics. Nuclear Proteins / genetics
  • [MeSH-minor] Apoptosis. Aurora Kinases. Brain / metabolism. Cell Division. Cell Line, Tumor. Cyclin B1 / genetics. Cyclin D1 / genetics. Disease Progression. Down-Regulation. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Protein-Serine-Threonine Kinases / genetics. Proto-Oncogene Proteins c-myc / genetics. Survival Rate. Tumor Suppressor Protein p53 / genetics

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • Xenbase. Xenbase .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20599806.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin B1; 0 / Microtubule-Associated Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / TPX2 protein, human; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  •  go-up   go-down


74. Valverde D, Quintero MR, Candiota AP, Badiella L, Cabañas ME, Arús C: Analysis of the changes in the 1H NMR spectral pattern of perchloric acid extracts of C6 cells with growth. NMR Biomed; 2006 Apr;19(2):223-30
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cultured C6 ATCC rat glioma cells were used as models for this purpose and metabolites were extracted with perchloric acid at three different growth curve stages: log, confluence and post-confluence.
  • The fact that both myo-inositol and glutamine are detectable by in vivo MRS at clinical fields makes their changes relevant as potential astrocytic tumour proliferation rate markers in clinical MRS.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Glioma / physiopathology. Magnetic Resonance Spectroscopy / methods. Perchlorates / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Proliferation. Metabolic Clearance Rate. Protons. Rats. Tissue Extracts / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16485320.001).
  • [ISSN] 0952-3480
  • [Journal-full-title] NMR in biomedicine
  • [ISO-abbreviation] NMR Biomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Perchlorates; 0 / Protons; 0 / Tissue Extracts
  •  go-up   go-down


75. Ohta K, Kuwahara K, Zhang Z, Makino K, Komohara Y, Nakamura H, Kuratsu J, Sakaguchi N: Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas. Cancer Sci; 2009 Nov;100(11):2069-76
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas.
  • Malignant glioma (MG) is highly proliferative and invasive, with the malignant characteristics associated with aneuploidy and chromosomal instability (CIN).
  • Glioblastomas showed a significantly lower level of ganp mRNA than anaplastic astrocytomas, as measured by real-time reverse transcription-PCR, in 101 cases of adult MG.
  • [MeSH-major] Acetyltransferases / physiology. Brain Neoplasms / genetics. Chromosomal Instability. Glioma / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Cycle. Cell Line, Tumor. Cell Proliferation. Female. Genes, p53. Humans. Intracellular Signaling Peptides and Proteins. Loss of Heterozygosity. Male. Middle Aged. Mutation. RNA Interference. Receptor, Epidermal Growth Factor / genetics

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • Saccharomyces Genome Database. Saccharomyces Genome Database .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19686285.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; EC 2.3.1.- / Acetyltransferases; EC 2.3.1.- / MCM3AP protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  •  go-up   go-down


76. Montemor JP, Peria FM, Monti CR, Petrilli LS, Colli BO, Carlotti Júnior CG: Concurrent chemoradiotherapy with weekly paclitaxel in malignant cerebral glioma treatment. Onkologie; 2008 Sep;31(8-9):435-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent chemoradiotherapy with weekly paclitaxel in malignant cerebral glioma treatment.
  • BACKGROUND: Anaplastic astrocytomas (AA) and glioblastomas (GB) are the most common malignant gliomas, and despite newly developed drugs and combined treatments, they still have an adverse prognosis.
  • Paclitaxel is a cytotoxic agent with radiosensitizing properties and exerts objective growth inhibition in glioma tumor cells.
  • CONCLUSIONS: Chemoradiotherapy with weekly paclitaxel is safe and tolerable although there was no increase in the overall survival and 12-month survival of malignant glioma patients.
  • [MeSH-major] Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy. Glioma / drug therapy. Glioma / radiotherapy. Paclitaxel / administration & dosage

  • Genetic Alliance. consumer health - Glioma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • Hazardous Substances Data Bank. TAXOL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18787350.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; P88XT4IS4D / Paclitaxel
  •  go-up   go-down


77. Ikota H, Kinjo S, Yokoo H, Nakazato Y: Systematic immunohistochemical profiling of 378 brain tumors with 37 antibodies using tissue microarray technology. Acta Neuropathol; 2006 May;111(5):475-82
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Our TMA consisted of a grid of 1.5-mm cores that were extracted from individual donor blocks.
  • Ten antibodies [glial fibrillary acidic protein (GFAP), Olig2, vimentin, epithelial membrane antigen (EMA), cytokeratin (AE1/AE3), alpha-internexin, nestin, pinealocytes PP5, aquaporin-4 (AQP4) M13d and AQP4M13e] discriminated between astrocytomas and oligodendroglial tumors.
  • Six antibodies [EMA, AE1/AE3, TUJ1, nestin, neurofilament protein-MH (NF-MH) and perivascular cells GP-1] showed significant differences between high-grade and low-grade gliomas.
  • Our data have revealed new antibodies with potential diagnostic utility (Olig2, PP5, GP-1) and demonstrate that TMA technology is highly useful for evaluating newly established antibodies in brain-tumor research.
  • [MeSH-major] Antibodies / immunology. Astrocytoma / immunology. Brain Neoplasms / immunology. Immunohistochemistry / methods. Oligodendroglioma / immunology. Protein Array Analysis / methods
  • [MeSH-minor] Aquaporin 4 / immunology. Aquaporin 4 / metabolism. Basic Helix-Loop-Helix Transcription Factors / immunology. Basic Helix-Loop-Helix Transcription Factors / metabolism. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Cluster Analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / immunology. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / immunology. Intermediate Filament Proteins / metabolism. Mucin-1 / immunology. Mucin-1 / metabolism. Nerve Tissue Proteins / immunology. Nerve Tissue Proteins / metabolism. Nestin. Prognosis. Vimentin / immunology. Vimentin / metabolism

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16598485.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / AQP4 protein, human; 0 / Antibodies; 0 / Aquaporin 4; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Mucin-1; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / OLIG2 protein, human; 0 / Vimentin; 0 / alpha-internexin
  •  go-up   go-down


78. Kitis O, Altay H, Calli C, Yunten N, Akalin T, Yurtseven T: Minimum apparent diffusion coefficients in the evaluation of brain tumors. Eur J Radiol; 2005 Sep;55(3):393-400
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To determine whether diffusion-weighted imaging by using minimum apparent diffusion coefficient (ADC(min)) values could differentiate various brain tumors including gliomas, metastases, and lymphomas.
  • MATERIALS AND METHODS: We examined 65 patients with histologically or clinically diagnosed brain tumors (12 low-grade gliomas, 31 high-grade gliomas, 14 metastatic tumors, and 8 lymphomas) using a 1.5 T MR unit.
  • RESULTS: The ADC(min) values of low-grade gliomas (1.09+/-0.20 x 10(-3)mm(2)/s) were significantly higher (p<.001) than those of other tumors.
  • There were no statistical significant differences between glioblastomas (0.70+/-0.16 mm(2)/s), anaplastic astrocytomas (0.77+/-0.21 mm(2)/s), metastases (0.78+/-0.21 mm(2)/s), and lymphomas.
  • But, lymphomas had lower mean ADC(min) values (0.54+/-0.10mm(2)/s) than high-grade gliomas and metastases.
  • CONCLUSION: The ADC measurements may help to differentiate low-grade gliomas from high-grade gliomas, metastases, and lymphomas.
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Diagnosis, Differential. Female. Glioma / pathology. Humans. Lymphoma / pathology. Male. Middle Aged. Neoplasm Metastasis / pathology

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16129247.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


79. Mishima K, Kato Y, Kaneko MK, Nishikawa R, Hirose T, Matsutani M: Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. Acta Neuropathol; 2006 May;111(5):483-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression.
  • However, little information exists about its role in CNS astrocytic tumors.
  • In this study, 188 astrocytic tumors (30 diffuse astrocytomas, 43 anaplastic astrocytomas, and 115 glioblastomas) were investigated using immunohistochemistry with an anti-podoplanin antibody, YM-1.
  • In 11 of 43 anaplastic astrocytomas (25.6%) and in 54 of 115 glioblastomas (47.0%), podoplanin was expressed on the surface of anaplastic astrocytoma cells and glioblastoma cells, especially around necrotic areas and proliferating endothelial cells.
  • On the other hand, podoplanin expression was not observed in diffuse astrocytoma (0/30: 0%).
  • Furthermore, we investigated the expression of podoplanin using quantitative real-time PCR and Western blot analysis in 54 frozen astrocytic tumors (6 diffuse astrocytomas, 14 anaplastic astrocytomas, and 34 glioblastomas).
  • Podoplanin mRNA and protein expression were markedly higher in glioblastomas than in anaplastic astrocytomas.
  • These data suggest that podoplanin expression might be associated with malignancy of astrocytic tumors.
  • [MeSH-major] Astrocytoma / metabolism. Central Nervous System Neoplasms / metabolism. Glioblastoma / metabolism. Membrane Glycoproteins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Blotting, Western. Disease Progression. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. RNA, Messenger / genetics. RNA, Messenger / metabolism

  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16596424.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / RNA, Messenger
  •  go-up   go-down


80. Morales H, Kwock L, Castillo M: Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas. J Comput Assist Tomogr; 2007 Sep-Oct;31(5):682-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas.
  • BACKGROUND AND PURPOSE: Pilomyxoid astrocytomas (PMAs) have been described only recently.
  • They appear as low-grade tumors sharing imaging features similar to pilocytic astrocytomas (PAs).
  • However, pilomyxoid astrocytomas have different histological features and behave more aggressively than PAs.
  • [MeSH-major] Astrocytoma / metabolism. Astrocytoma / pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Magnetic Resonance Imaging / methods. Magnetic Resonance Spectroscopy / methods. Myxoma / metabolism. Myxoma / pathology

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • Hazardous Substances Data Bank. CREATINE .
  • Hazardous Substances Data Bank. CHOLINE CHLORIDE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17895777.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4L6452S749 / Inositol; MU72812GK0 / Creatine; N91BDP6H0X / Choline
  •  go-up   go-down


81. Fakhrai H, Mantil JC, Liu L, Nicholson GL, Murphy-Satter CS, Ruppert J, Shawler DL: Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma. Cancer Gene Ther; 2006 Dec;13(12):1052-60
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma.
  • We performed a phase I clinical trial in grade IV astrocytoma to assess the safety of a whole-cell vaccine comprising autologous tumor cells genetically modified by a transforming growth factor-beta2 (TGF-beta2) antisense vector.
  • Blocking secretion of the immunosuppressive molecule TGF-beta in this manner should inhibit one of the major mechanisms by which tumor cells evade immune surveillance and should lead to clinically effective antitumor immunity.
  • Six patients with progressive WHO grade IV astrocytoma were enrolled in the trial.
  • Patients received 2-7 subcutaneous injections of 5 x 10(6)-2 x 10(7) autologous tumor cells per injection.
  • TGF-beta2 secretion by the tumor cells used to vaccinate patients was inhibited by 53-98%.
  • Two patients had partial regressions and two had stable disease following therapy.
  • Median survival of the responding patients was 78 weeks, compared to a historic value of 47 weeks for glioma patients treated conventionally.
  • These findings support further clinical evaluation of vaccines comprised of TGF-beta antisense-modified tumor cells.
  • [MeSH-major] Cancer Vaccines / therapeutic use. Central Nervous System Neoplasms / drug therapy. Glioma / drug therapy. Oligonucleotides, Antisense / genetics. Transforming Growth Factor beta2 / genetics
  • [MeSH-minor] Adult. Antibody Formation. Female. Humans. Injections, Intradermal. Male. Middle Aged. Treatment Outcome. Tumor Cells, Cultured

  • Genetic Alliance. consumer health - Glioma.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16826191.001).
  • [ISSN] 0929-1903
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA105964; United States / NCI NIH HHS / CA / CA96025
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / Oligonucleotides, Antisense; 0 / Transforming Growth Factor beta2
  •  go-up   go-down


82. Opstad KS, Bell BA, Griffiths JR, Howe FA: Taurine: a potential marker of apoptosis in gliomas. Br J Cancer; 2009 Mar 10;100(5):789-94
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Taurine: a potential marker of apoptosis in gliomas.
  • Magnetic resonance spectroscopy (MRS) can determine the tumour biochemical profile in vivo, and we have investigated whether a specific spectroscopic signature exists for apoptosis in human astrocytomas.
  • Metabolites, mobile lipids and macromolecules were quantified from presaturation HRMAS (1)H spectra acquired from 41 biopsies of grades II (n=8), III (n=3) and IV (n=30) astrocytomas.
  • We suggest that the taurine (1)H MRS signal in astrocytomas may be a robust apoptotic biomarker that is independent of tumour necrotic status.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • Hazardous Substances Data Bank. Taurine .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Nat Med. 1999 Nov;5(11):1323-7 [10546002.001]
  • [Cites] NMR Biomed. 2008 Nov;21(10):1138-47 [18666093.001]
  • [Cites] Pflugers Arch. 2000 May;440(1):93-9 [10864002.001]
  • [Cites] NMR Biomed. 2000 May;13(3):129-53 [10861994.001]
  • [Cites] Bioessays. 2000 Nov;22(11):1007-17 [11056477.001]
  • [Cites] Magn Reson Med. 2001 Mar;45(3):409-14 [11241697.001]
  • [Cites] Biochim Biophys Acta. 2001 Jan 15;1530(1):47-66 [11341958.001]
  • [Cites] Cancer Res. 2002 Mar 1;62(5):1394-400 [11888911.001]
  • [Cites] Br J Cancer. 2002 Mar 18;86(6):963-70 [11953830.001]
  • [Cites] Toxicol Pathol. 2002 Sep-Oct;30(5):541-51 [12371662.001]
  • [Cites] Microsc Microanal. 2002 Oct;8(5):375-91 [12533214.001]
  • [Cites] Cancer Res. 2003 Jun 15;63(12):3195-201 [12810648.001]
  • [Cites] NMR Biomed. 2003 Jun;16(4):199-212 [14558118.001]
  • [Cites] Biochim Biophys Acta. 2003 Oct 20;1634(1-2):1-14 [14563408.001]
  • [Cites] Magn Reson Med. 2003 Dec;50(6):1307-11 [14648580.001]
  • [Cites] Neurosurgery. 2004 Oct;55(4):824-9; discussion 829 [15458590.001]
  • [Cites] Semin Oncol. 2004 Oct;31(5):595-604 [15497113.001]
  • [Cites] J Neurochem. 1981 Feb;36(2):406-10 [7463068.001]
  • [Cites] J Cell Biol. 1992 Nov;119(3):493-501 [1400587.001]
  • [Cites] Lab Invest. 1994 Aug;71(2):219-25 [8078301.001]
  • [Cites] J Neurochem. 1994 Oct;63(4):1538-43 [7931308.001]
  • [Cites] Cancer Res. 1997 Feb 1;57(3):407-14 [9012466.001]
  • [Cites] Cancer Res. 1998 May 1;58(9):1825-32 [9581820.001]
  • [Cites] Magn Reson Med. 1999 Sep;42(3):454-60 [10467289.001]
  • [Cites] Biochim Biophys Acta. 2005 May 1;1734(1):1-12 [15866478.001]
  • [Cites] Magn Reson Med. 2005 Jul;54(1):43-50 [15968678.001]
  • [Cites] J Physiol. 2005 Sep 1;567(Pt 2):427-43 [15975986.001]
  • [Cites] BMC Cancer. 2007;7:11 [17233882.001]
  • [Cites] NMR Biomed. 2008 Aug;21(7):677-85 [18186027.001]
  • [Cites] Magn Reson Med. 2008 Nov;60(5):1237-42 [18836999.001]
  • [Cites] Pflugers Arch. 2000 Jan;439(3):271-7 [10650978.001]
  • (PMID = 19223899.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United Kingdom / Cancer Research UK / / C1459/A2592
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 1EQV5MLY3D / Taurine
  • [Other-IDs] NLM/ PMC2653765
  •  go-up   go-down


83. Greco Crasto S, Soffietti R, Rudà R, Cassoni P, Ducati A, Davini O, De Lucchi R, Rizzo L: Diffusion-Weighted Magnetic Resonance Imaging and ADC Maps in the Diagnosis of Intracranial Cystic or Necrotic Lesions. A Retrospective Study on 49 Patients. Neuroradiol J; 2007 Dec 31;20(6):666-75
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eleven tumours (11/44) appeared hyperintense on DWI: eight metastases from lung cancer (mean ADC value 0.86 mm(2)/s, range 0.75-1.2 mm(2)/s), two GBMs (mean 0.7 mm(2)/s, range 0.67-0.76 mm(2)/s) and one anaplastic astrocytoma (ADC value 1.24 mm(2)/s).

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 24300002.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


84. Harris LM, Davies N, Macpherson L, Foster K, Lateef S, Natarajan K, Sgouros S, Brundler MA, Arvanitis TN, Grundy RG, Peet AC: The use of short-echo-time 1H MRS for childhood cerebellar tumours prior to histopathological diagnosis. Pediatr Radiol; 2007 Nov;37(11):1101-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types.
  • NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours.
  • [MeSH-major] Aspartic Acid / analogs & derivatives. Biomarkers, Tumor / analysis. Cerebellar Neoplasms / diagnosis. Cerebellar Neoplasms / metabolism. Choline / analysis. Creatine / analysis. Inositol / analysis. Magnetic Resonance Spectroscopy / methods

  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. (L)-ASPARTIC ACID .
  • Hazardous Substances Data Bank. CREATINE .
  • Hazardous Substances Data Bank. CHOLINE CHLORIDE .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer. 2004 Mar 15;100(6):1246-56 [15022293.001]
  • [Cites] Comput Biol Med. 2001 Jul;31(4):269-86 [11334636.001]
  • [Cites] J Magn Reson Imaging. 2006 Feb;23(2):99-107 [16374884.001]
  • [Cites] J Magn Reson. 2004 Sep;170(1):164-75 [15324770.001]
  • [Cites] Med Sci Monit. 2003 Sep;9(9):MT97-105 [12960934.001]
  • [Cites] J Neurooncol. 1999;45(1):69-81 [10728912.001]
  • [Cites] Radiology. 2005 Sep;236(3):1020-5 [16118174.001]
  • [Cites] NMR Biomed. 1997 May;10(3):99-124 [9408920.001]
  • [Cites] Magn Reson Med. 2005 Jan;53(1):22-9 [15690498.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):20-31 [15850898.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2002 Apr 1;52(5):1271-6 [11955739.001]
  • [Cites] AJNR Am J Neuroradiol. 2006 Mar;27(3):560-72 [16551993.001]
  • [Cites] NeuroRx. 2005 Apr;2(2):197-214 [15897945.001]
  • [Cites] Oncologist. 2004;9(3):312-8 [15169986.001]
  • [Cites] Magn Reson Med. 2003 Jan;49(1):29-36 [12509817.001]
  • [Cites] Magn Reson Imaging. 2004 Sep;22(7):1017-24 [15288143.001]
  • [Cites] NMR Biomed. 1998 Jun-Aug;11(4-5):192-200 [9719573.001]
  • [Cites] J Clin Oncol. 2000 Mar;18(5):1020-6 [10694552.001]
  • [Cites] AJNR Am J Neuroradiol. 2006 Aug;27(7):1404-11 [16908548.001]
  • [Cites] Childs Nerv Syst. 2007 Feb;23(2):163-9 [17106750.001]
  • [Cites] Magn Reson Med. 2005 Dec;54(6):1333-9 [16265633.001]
  • [Cites] Neurosurgery. 2000 Feb;46(2):306-18 [10690719.001]
  • [Cites] AJNR Am J Neuroradiol. 1995 Oct;16(9):1821-33 [8693982.001]
  • [Cites] NMR Biomed. 1998 Jun-Aug;11(4-5):225-34 [9719577.001]
  • [Cites] Mol Cancer Ther. 2003 May;2(5):497-507 [12748312.001]
  • [Cites] Magn Reson Med. 1993 Dec;30(6):672-9 [8139448.001]
  • [Cites] Nat Med. 1996 Mar;2(3):323-5 [8612232.001]
  • [Cites] NMR Biomed. 2003 May;16(3):123-31 [12884355.001]
  • [Cites] Clin Cancer Res. 2004 Dec 15;10(24):8220-8 [15623597.001]
  • [Cites] Eur J Cancer. 2007 Apr;43(6):1037-44 [17349783.001]
  • [Cites] NMR Biomed. 2004 Oct;17(6):361-81 [15468083.001]
  • [Cites] Eur J Cancer. 2003 Apr;39(6):728-35 [12651196.001]
  • [Cites] NMR Biomed. 2006 Jun;19(4):411-34 [16763971.001]
  • (PMID = 17823793.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0601327
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons; 30KYC7MIAI / Aspartic Acid; 4L6452S749 / Inositol; 997-55-7 / N-acetylaspartate; MU72812GK0 / Creatine; N91BDP6H0X / Choline
  •  go-up   go-down


85. Janzarik WG, Kratz CP, Loges NT, Olbrich H, Klein C, Schäfer T, Scheurlen W, Roggendorf W, Weiller C, Niemeyer C, Korinthenberg R, Pfister S, Omran H: Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. Neuropediatrics; 2007 Apr;38(2):61-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.
  • Astrocytomas are the most common brain tumors of childhood.
  • However, knowledge of the molecular etiology of astrocytomas WHO grade I and II is limited.
  • Germline mutations in the Ras-guanosine triphosphatase-activating protein, neurofibromin, in individuals with neurofibromatosis type I predispose to pilocytic astrocytomas.
  • This association suggests that constitutive activation of the Ras signaling pathway plays a fundamental role in astrocytoma development.
  • We screened 25 WHO I and II astrocytomas for mutations of PTPN11, NRAS, KRAS, and HRAS genes and identified the somatic G12A KRAS mutation in one pilocytic astrocytoma.
  • Analyzed astrocytomas without mutations in Ras or neurofibromin may harbor mutations in other proteins of this pathway leading to hyperactive Ras signaling.
  • [MeSH-major] Astrocytoma / genetics. Brain Neoplasms / genetics. Mutation / genetics. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins p21(ras) / genetics. ras Proteins / genetics

  • Genetic Alliance. consumer health - Pilocytic astrocytoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17712732.001).
  • [ISSN] 0174-304X
  • [Journal-full-title] Neuropediatrics
  • [ISO-abbreviation] Neuropediatrics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); EC 3.6.5.2 / ras Proteins
  •  go-up   go-down


86. Terasaki M, Tokutomi T, Shigemori M: Salvage therapy with temozolomide for recurrent or progressive high-grade gliomas refractory to ACNU [1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride]. Mol Med Rep; 2009 May-Jun;2(3):417-21
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salvage therapy with temozolomide for recurrent or progressive high-grade gliomas refractory to ACNU [1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride].
  • This study aimed to determine safety, response rate, toxicity and 6-month progression-free survival (PFS) by using temozolomide (TMZ) as salvage chemotherapy for 25 adults with recurrent or progressive high-grade gliomas (HGGs) who failed 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) therapy.
  • Twenty-six patients with recurrent or progressive ACNU refractory HGG, including 12 with glioblastoma (GBM) and 13 with anaplastic astrocytoma (AA) were evaluated in a prospective study of temozolomide salvage chemotherapy.
  • The best response to chemotherapy had no impact on the duration of disease control.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21475844.001).
  • [ISSN] 1791-3004
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


87. Haidinger M, Hecking M, Weichhart T, Poglitsch M, Enkner W, Vonbank K, Prayer D, Geusau A, Oberbauer R, Zlabinger GJ, Soleiman A, Hörl WH, Säemann MD: Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity. Transpl Int; 2010 Aug;23(8):777-85
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Beneficial effects of sirolimus against TSC were detected in the skin, along with improved spirometric measurements and an arrest of astrocytoma progression.

  • Genetic Alliance. consumer health - Tuberous sclerosis.
  • MedlinePlus Health Information. consumer health - Kidney Transplantation.
  • MedlinePlus Health Information. consumer health - Tuberous Sclerosis.
  • Hazardous Substances Data Bank. SIROLIMUS .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20070623.001).
  • [ISSN] 1432-2277
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calcineurin Inhibitors; 0 / Immunosuppressive Agents; 0 / Intracellular Signaling Peptides and Proteins; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; W36ZG6FT64 / Sirolimus
  •  go-up   go-down


88. Perry SL, Bohlin C, Reardon DA, Desjardins A, Friedman AH, Friedman HS, Vredenburgh JJ: Tinzaparin prophylaxis against venous thromboembolic complications in brain tumor patients. J Neurooncol; 2009 Oct;95(1):129-134
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tinzaparin prophylaxis against venous thromboembolic complications in brain tumor patients.
  • The purpose of this study was to determine the safety of tinzaparin for deep vein thrombosis prophylaxis in newly diagnosed grade III-IV malignant glioma patients.
  • Forty patients were enrolled into the study, 35 with glioblastoma multiforme and 5 with anaplastic astrocytoma.
  • Tinzaparin at a fixed prophylactic dose is safe and may decrease the incidence of thromboembolic complications in brain tumor patients.
  • [MeSH-major] Brain Neoplasms / complications. Fibrinolytic Agents / therapeutic use. Glioma / complications. Heparin, Low-Molecular-Weight / therapeutic use. Venous Thromboembolism / etiology. Venous Thromboembolism / prevention & control

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Oncol. 2005 Apr 1;23(10):2130-5 [15699479.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009.001]
  • [Cites] J Thromb Haemost. 2007 May;5(5):955-62 [17461929.001]
  • [Cites] Surg Neurol. 2008 Aug;70(2):117-21; discussion 121 [18262633.001]
  • [Cites] Neuro Oncol. 2008 Jun;10(3):355-60 [18436627.001]
  • [Cites] J Thromb Haemost. 2010 Sep;8(9):1959-65 [20598077.001]
  • [Cites] J Clin Oncol. 1999 Nov;17(11):3389-95 [10550132.001]
  • [Cites] Oncologist. 1999;4(6):443-9 [10631688.001]
  • [Cites] Arch Intern Med. 2000 Aug 14-28;160(15):2327-32 [10927730.001]
  • [Cites] Chest. 2001 Jan;119(1 Suppl):132S-175S [11157647.001]
  • [Cites] Semin Radiat Oncol. 2001 Apr;11(2):163-9 [11285554.001]
  • [Cites] Arch Intern Med. 2001 May 28;161(10):1268-79 [11371254.001]
  • [Cites] J Neurosurg Sci. 2001 Dec;45(4):195-201; discussion 201 [11912469.001]
  • [Cites] J Neurooncol. 2002 Aug;59(1):39-47 [12222837.001]
  • [Cites] J Neurol. 2002 Oct;249(10):1409-12 [12382158.001]
  • [Cites] Chest. 2002 Dec;122(6):1933-7 [12475829.001]
  • [Cites] CA Cancer J Clin. 2003 Jan-Feb;53(1):5-26 [12568441.001]
  • [Cites] N Engl J Med. 2003 Jul 10;349(2):109-11 [12853582.001]
  • [Cites] N Engl J Med. 2003 Jul 10;349(2):146-53 [12853587.001]
  • [Cites] South Med J. 2004 Feb;97(2):213-4 [14982286.001]
  • [Cites] J Clin Oncol. 2004 May 15;22(10):1944-8 [15143088.001]
  • [Cites] J Thromb Haemost. 2004 Aug;2(8):1266-71 [15304029.001]
  • [Cites] Ann Neurol. 1983 Mar;13(3):334-6 [6303201.001]
  • [Cites] JAMA. 1988 Sep 2;260(9):1255-8 [3404638.001]
  • [Cites] Lancet. 1992 Jul 18;340(8812):152-6 [1352573.001]
  • [Cites] Mayo Clin Proc. 1994 Apr;69(4):329-32 [8170176.001]
  • [Cites] Neurology. 1993 Jun;43(6):1111-4 [8170553.001]
  • [Cites] Thromb Haemost. 1996 Feb;75(2):233-8 [8815566.001]
  • [Cites] N Engl J Med. 1996 Sep 5;335(10):701-7 [8703169.001]
  • [Cites] N Engl J Med. 1997 Sep 4;337(10):688-98 [9278467.001]
  • [Cites] Br J Surg. 1997 Aug;84(8):1099-103 [9278651.001]
  • [Cites] Eur J Cancer. 1997 Sep;33(10):1592-6 [9389920.001]
  • [Cites] N Engl J Med. 1998 Jul 9;339(2):80-5 [9654538.001]
  • [Cites] J Formos Med Assoc. 1999 May;98(5):365-7 [10420706.001]
  • [Cites] J Clin Oncol. 2005 Apr 1;23(10):2123-9 [15699480.001]
  • (PMID = 19415455.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / K23 HL084233-02; United States / NHLBI NIH HHS / HL / K23 HL084233-03; United States / NHLBI NIH HHS / HL / K23 HL084233; United States / NHLBI NIH HHS / HL / K23 HL084233-01A1; United States / NHLBI NIH HHS / HL / K23-HL084233-02
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrinolytic Agents; 0 / Heparin, Low-Molecular-Weight; 7UQ7X4Y489 / tinzaparin
  • [Other-IDs] NLM/ NIHMS180651; NLM/ PMC2837514
  •  go-up   go-down


89. Pinto GR, Clara CA, Santos MJ, Almeida JR, Burbano RR, Rey JA, Casartelli C: Mutation analysis of gene PAX6 in human gliomas. Genet Mol Res; 2007;6(4):1019-25
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mutation analysis of gene PAX6 in human gliomas.
  • Gliomas are the most common tumors of the central nervous system.
  • In spite of the marked advances in the characterization of the molecular pathogenesis of gliomas, these tumors remain incurable and, in most of the cases, resistant to treatments, due to their molecular heterogeneity.
  • Gene PAX6, which encodes a transcription factor that plays an important role in the development of the central nervous system, was recently recognized as a tumor suppressor in gliomas.
  • The objective of the present study was to analyze the mutational status of the coding and regulating regions of PAX6 in 94 gliomas: 81 astrocytomas (11 grade I, 23 grade II, 8 grade III, and 39 grade IV glioblastomas), 5 oligodendrogliomas (3 grade II, and 2 grade III), and 8 ependymomas (5 grade II, and 3 grade III).
  • Therefore, we conclude that the tumor suppressor role of PAX6, reported in previous studies on gliomas, is not due to mutation in its coding and regulating regions, suggesting the involvement of epigenetic mechanisms in the silencing of PAX6 in these tumors.
  • [MeSH-major] Central Nervous System Neoplasms / genetics. Eye Proteins / genetics. Glioma / genetics. Homeodomain Proteins / genetics. Mutation. Paired Box Transcription Factors / genetics. Repressor Proteins / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Astrocytoma / genetics. Base Sequence. Child. Child, Preschool. DNA Mutational Analysis. DNA Primers / genetics. DNA, Neoplasm / genetics. Ependymoma / genetics. Epigenesis, Genetic. Female. Gene Silencing. Humans. Infant. Male. Middle Aged. Oligodendroglioma / genetics. Polymerase Chain Reaction

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18273794.001).
  • [ISSN] 1676-5680
  • [Journal-full-title] Genetics and molecular research : GMR
  • [ISO-abbreviation] Genet. Mol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Neoplasm; 0 / Eye Proteins; 0 / Homeodomain Proteins; 0 / PAX6 protein; 0 / Paired Box Transcription Factors; 0 / Repressor Proteins
  •  go-up   go-down


90. Song HY, Ryu J, Ju SM, Park LJ, Lee JA, Choi SY, Park J: Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes. Exp Mol Med; 2007 Feb 28;39(1):27-37
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we examined the effect of HIV-1 Tat on the expression of adhesion molecules, generation of reactive oxygen species (ROS) and NF-kappaB activation in CRT-MG human astroglioma cells.

  • Genetic Alliance. consumer health - HIV.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17334226.001).
  • [ISSN] 1226-3613
  • [Journal-full-title] Experimental & molecular medicine
  • [ISO-abbreviation] Exp. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Gene Products, tat; 0 / NF-kappa B; 0 / Reactive Oxygen Species; 0 / Vascular Cell Adhesion Molecule-1; 0 / tat Gene Products, Human Immunodeficiency Virus; 126547-89-5 / Intercellular Adhesion Molecule-1
  •  go-up   go-down


91. Steinbrenner H, Alili L, Bilgic E, Sies H, Brenneisen P: Involvement of selenoprotein P in protection of human astrocytes from oxidative damage. Free Radic Biol Med; 2006 May 1;40(9):1513-23
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We show that primary human astrocytes and the human astrocytoma cell line MOG-G-CCM express SeP as an unglycosylated protein, which is not secreted.
  • [MeSH-minor] Blotting, Western. Cell Line, Tumor. Cell Survival / drug effects. Cells, Cultured. Glutathione Peroxidase / drug effects. Glutathione Peroxidase / metabolism. Humans. RNA, Small Interfering. Reverse Transcriptase Polymerase Chain Reaction. Selenium / pharmacology. Transfection. tert-Butylhydroperoxide / toxicity

  • MedlinePlus Health Information. consumer health - Antioxidants.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. TERT-BUTYL HYDROPEROXIDE .
  • Hazardous Substances Data Bank. SELENIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16632112.001).
  • [ISSN] 0891-5849
  • [Journal-full-title] Free radical biology & medicine
  • [ISO-abbreviation] Free Radic. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / RNA, Small Interfering; 0 / Selenoprotein P; 955VYL842B / tert-Butylhydroperoxide; EC 1.11.1.9 / Glutathione Peroxidase; H6241UJ22B / Selenium
  •  go-up   go-down


92. Pei Y, Wechsler-Reya RJ: A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas. Cancer Cell; 2010 Dec 14;18(6):546-7
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent studies have suggested that brain tumors arise from neural stem cells and are maintained by stem-like tumor-initiating cells (TICs).
  • In this issue of Cancer Cell, Persson et al. report that oligodendrogliomas, unlike malignant astrocytomas, originate from-and are propagated by-cells that resemble oligodendrocyte progenitors.

  • COS Scholar Universe. author profiles.
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • [CommentOn] Cancer Cell. 2010 Dec 14;18(6):669-82 [21156288.001]
  • (PMID = 21156279.001).
  • [ISSN] 1878-3686
  • [Journal-full-title] Cancer cell
  • [ISO-abbreviation] Cancer Cell
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA122759-01A2; United States / NCI NIH HHS / CA / CA122759-02; United States / NCI NIH HHS / CA / R01 CA122759-01A2; United States / NCI NIH HHS / CA / R01 CA122759-02; United States / NCI NIH HHS / CA / R01 CA122759; United States / NCI NIH HHS / CA / R01 CA122759-03
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS257439; NLM/ PMC3012268
  •  go-up   go-down


93. Sulman EP, Guerrero M, Aldape K: Beyond grade: molecular pathology of malignant gliomas. Semin Radiat Oncol; 2009 Jul;19(3):142-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Beyond grade: molecular pathology of malignant gliomas.
  • High-grade gliomas (HGGs) represent a heterogenous group of tumors and account for most primary brain tumors.
  • These tumors include the anaplastic (World Health Organization [WHO] grade III) histologies of astrocytomas, oligodendrogliomas, and ependymomas and the WHO grade IV glioblastoma multiforme (GBM).
  • Prognostication for patients with these tumors has relied principally on tumor grade and clinical factors (age, performance status, and so on) and has been inexact at best in identifying those with long-term survival potential.
  • An even greater challenge has been to identify predictive biomarkers of therapy in the hope of tailoring a patient's therapy based on their tumor's molecular characteristics.
  • This review discusses the molecular pathology of high-grade gliomas, with particular emphasis on anaplastic astrocytomas and GBMs because these represent the most common forms of malignant gliomas.
  • [MeSH-major] Brain Neoplasms / genetics. Glioma / genetics
  • [MeSH-minor] Biomarkers, Tumor. Gene Expression Profiling. Humans. Prognosis

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19464628.001).
  • [ISSN] 1532-9461
  • [Journal-full-title] Seminars in radiation oncology
  • [ISO-abbreviation] Semin Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


94. Hattingen E, Franz K, Pilatus U, Weidauer S, Lanfermann H: Postictal spectroscopy and imaging findings mimicking brain tumor recurrence. J Magn Reson Imaging; 2006 Jul;24(1):226-30
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postictal spectroscopy and imaging findings mimicking brain tumor recurrence.
  • (1)H magnetic resonance spectroscopic imaging (MRSI) was performed on a patient with an admission diagnosis of recurrent astrocytoma.
  • The patient had undergone surgical resection and radiation therapy for a left occipital astrocytoma WHO grade III 12 years previously, and presented with aphasia, right-sided hemiparesis, and severe headache.
  • The spectroscopic data were consistent with tumor recurrence.
  • However, the pattern of contrast enhancement on magnetic resonance imaging (MRI), evidence of an epileptic focus on electroencephalography (EEG), and spontaneous regression of the symptoms argued against tumor recurrence.
  • This is the first report of seizure-induced MRS abnormalities mimicking tumor recurrence.
  • [MeSH-minor] Adult. Aphasia / diagnosis. Aphasia / pathology. Astrocytoma / diagnosis. Astrocytoma / pathology. Contrast Media / pharmacology. Diagnosis, Differential. Electroencephalography / methods. Headache / pathology. Humans. Magnetic Resonance Imaging / methods. Paresis / diagnosis. Paresis / pathology. Recurrence

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Seizures.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16739121.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  •  go-up   go-down


95. Donato G, Iofrida G, Lavano A, Volpentesta G, Signorelli F, Pallante PL, Berlingieri MT, Pierantoni MG, Palmieri D, Conforti F, Maltese L, Tucci L, Amorosi A, Fusco A: Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors. Clin Neuropathol; 2008 Jul-Aug;27(4):219-23
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
  • Previous studies suggest the expression of UbcH10 gene, that codes for a protein belonging to the ubiquitin-conjugating enzyme family, as a valid indicator of the proliferative and aggressive status of tumors of different origin.
  • Therefore, to look for possible tools to be used as diagnostic markers in astrocytic neoplasias, we investigated UbcH10 expression in normal brain, gliosis and low-grade and high-grade astrocytic tumors by immunohistochemistry.
  • UbcH10 expression was observed in low-grade astrocytoma and in glioblastoma.
  • Our data indicate a clear correlation between UbcH10 expression and the histological grade of the astrocytic tumors.
  • [MeSH-major] Astrocytoma / diagnosis. Astrocytoma / metabolism. Biomarkers, Tumor / analysis. Brain Neoplasms / diagnosis. Brain Neoplasms / metabolism. Ubiquitin-Conjugating Enzymes / biosynthesis

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18666437.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.3.2.19 / UBE2C protein, human; EC 6.3.2.19 / Ubiquitin-Conjugating Enzymes
  •  go-up   go-down


96. Vital AL, Tabernero MD, Crespo I, Rebelo O, Tão H, Gomes F, Lopes MC, Orfao A: Intratumoral patterns of clonal evolution in gliomas. Neurogenetics; 2010 May;11(2):227-39
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intratumoral patterns of clonal evolution in gliomas.
  • Few studies have explored the patterns of clonal evolution in gliomas.
  • Here, we investigate the cytogenetic patterns of intratumoral clonal evolution of gliomas and their impact on tumor histopathology and patient survival.
  • Cytogenetic analysis of 90 gliomas was performed in individual tumor cells (>200 cells/tumor) using multicolor (N = 16 probes) interphase-FISH.
  • Virtually, all cases (99%) showed >or=2 tumor cell clones, with higher numbers among high- versus low-grade gliomas (p = 0.001).
  • Nine different cytogenetic patterns were found in the ancestral tumor clones.
  • In most gliomas, ancestral clones showed abnormalities of chromosome 7, 9p, and/or 10q and cytogenetic evolution consisted of acquisition of additional abnormalities followed by tetraploidization.
  • Conversely, early tetraploidization was associated with low-grade astrocytomas-2/3 pilocytic and 3/6 grade II diffuse astrocytomas-and combined loss of 1p36/19q13 with oligodendrogliomas, respectively; both aberrations were associated with a better patient outcome (p = 0.03).
  • Overall, our results support the existence of different pathways of intratumoral evolution in gliomas.
  • [MeSH-major] Cytogenetic Analysis. Glioma / genetics. Glioma / pathology

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Clin Cancer Res. 2006 Sep 15;12(18):5268-72 [17000658.001]
  • [Cites] J Neuropathol Exp Neurol. 2002 Dec;61(12 ):1078-84 [12484570.001]
  • [Cites] Clin Neuropathol. 2005 Sep-Oct;24(5):209-18 [16167544.001]
  • [Cites] J Mol Diagn. 2004 Nov;6(4):316-25 [15507670.001]
  • [Cites] Am J Pathol. 2007 May;170(5):1445-53 [17456751.001]
  • [Cites] Arch Pathol Lab Med. 2007 Oct;131(10):1585-90 [17922598.001]
  • [Cites] Cancer Genet Cytogenet. 2008 Jul 15;184(2):77-86 [18617055.001]
  • [Cites] J Neuropathol Exp Neurol. 2000 Dec;59(12):1087-93 [11138928.001]
  • [Cites] J Neurooncol. 2007 Sep;84(2):201-11 [17569001.001]
  • [Cites] Cancer Res. 2003 Oct 15;63(20):6962-70 [14583498.001]
  • [Cites] EMBO J. 2007 Nov 14;26(22):4683-93 [17948060.001]
  • [Cites] J Mol Diagn. 2004 Aug;6(3):166-79 [15269292.001]
  • [Cites] Cancer Res. 2002 Nov 1;62(21):6205-10 [12414648.001]
  • [Cites] Int J Cancer. 2006 Aug 15;119(4):792-800 [16550607.001]
  • [Cites] J Cell Biochem. 2007 Dec 15;102(6):1368-74 [17972252.001]
  • [Cites] J Neuropathol Exp Neurol. 2006 Nov;65(11):1049-58 [17086101.001]
  • [Cites] Cancer Res. 1998 Oct 15;58(20):4694-700 [9788624.001]
  • [Cites] Int J Oncol. 2006 Feb;28(2):353-60 [16391789.001]
  • [Cites] Neoplasma. 2007;54(4):334-41 [17822324.001]
  • [Cites] Cancer Genet Cytogenet. 2004 May;151(1):36-51 [15120909.001]
  • [Cites] Cancer Cell. 2006 Mar;9(3):157-73 [16530701.001]
  • [Cites] J Neurooncol. 2008 May;88(1):57-63 [18253699.001]
  • [Cites] Genes Dev. 2001 Jun 1;15(11):1311-33 [11390353.001]
  • [Cites] J Neuropathol Exp Neurol. 2005 Jun;64(6):479-89 [15977639.001]
  • [Cites] Int J Oncol. 2001 Oct;19(4):673-80 [11562740.001]
  • [Cites] Clin Cancer Res. 2003 Oct 15;9(13):4841-51 [14581356.001]
  • [Cites] Cancer Genet Cytogenet. 2008 Jan 1;180(1):14-9 [18068527.001]
  • [Cites] Cancer Res. 2004 Oct 1;64(19):6892-9 [15466178.001]
  • [Cites] Acta Neuropathol. 2007 Aug;114(2):97-109 [17618441.001]
  • [Cites] J Med Invest. 2004 Aug;51(3-4):146-53 [15460900.001]
  • [Cites] Cancer Res. 2006 Oct 15;66(20):9852-61 [17047046.001]
  • [Cites] J Neuropathol Exp Neurol. 1996 Jul;55(7):822-31 [8965097.001]
  • [Cites] Brain Pathol. 2004 Apr;14(2):121-30 [15193024.001]
  • [Cites] Semin Oncol. 2004 Oct;31(5):595-604 [15497113.001]
  • [Cites] Curr Opin Genet Dev. 2007 Apr;17(2):157-62 [17324569.001]
  • [Cites] Arch Pathol Lab Med. 2007 Mar;131(3):397-406 [17516742.001]
  • [Cites] Neuropathology. 2007 Feb;27(1):10-20 [17319279.001]
  • [Cites] Clin Cancer Res. 2005 Feb 1;11(3):1119-28 [15709179.001]
  • [Cites] Am J Clin Oncol. 2001 Oct;24(5):506-8 [11586105.001]
  • [Cites] Cancer Res. 2003 Jan 15;63(2):413-6 [12543796.001]
  • [Cites] Cancer Genet Cytogenet. 2002 Jun;135(2):147-59 [12127399.001]
  • [Cites] Cancer. 2005 Aug 15;104(4):825-32 [15981281.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5814-9 [15827123.001]
  • [Cites] Clin Cancer Res. 2003 Sep 15;9(11):4151-8 [14519639.001]
  • [Cites] J Neuropathol Exp Neurol. 2006 Sep;65(9):846-54 [16957578.001]
  • [Cites] J Neuropathol Exp Neurol. 2003 Nov;62(11):1118-28 [14656070.001]
  • [Cites] Acta Neuropathol. 2005 Jan;109(1):93-108 [15685439.001]
  • [Cites] Clin Cancer Res. 2007 Dec 1;13(23):6933-7 [18056167.001]
  • [Cites] Cancer Res. 2008 Nov 1;68(21):8673-7 [18974108.001]
  • [Cites] J Neuropathol Exp Neurol. 2006 Dec;65(12):1181-8 [17146292.001]
  • [Cites] Cancer Res. 2003 Apr 1;63(7):1602-7 [12670911.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10 ):987-96 [15758009.001]
  • [Cites] Biochem Biophys Res Commun. 2006 Dec 15;351(2):336-9 [17067552.001]
  • [Cites] Clin Cancer Res. 2002 Jan;8(1):196-201 [11801559.001]
  • [Cites] Cancer Res. 2002 May 15;62(10):2897-905 [12019170.001]
  • [Cites] Acta Neuropathol. 2007 Feb;113(2):129-36 [17031656.001]
  • [Cites] J Neurosurg. 2002 May;96(5):815-22 [12005388.001]
  • [Cites] J Neuropathol Exp Neurol. 2008 Sep;67(9):878-87 [18716556.001]
  • [Cites] Neoplasma. 2007;54(3):212-8 [17447852.001]
  • (PMID = 19760258.001).
  • [ISSN] 1364-6753
  • [Journal-full-title] Neurogenetics
  • [ISO-abbreviation] Neurogenetics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


97. Melchior K, Tholey A, Heisel S, Keller A, Lenhof HP, Meese E, Huber CG: Proteomic study of human glioblastoma multiforme tissue employing complementary two-dimensional liquid chromatography- and mass spectrometry-based approaches. J Proteome Res; 2009 Oct;8(10):4604-14
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An extensive data set comprising 2660 unique protein identifications was obtained for the proteome of a human brain tumor (glioblastoma multiforme) by combining the results of two complementary analytical strategies based on two-dimensional chromatography and mass spectrometry.
  • The identified proteins were assigned to their molecular functions and compared to previously identified proteins of glioblastoma multiforme (= astrocytoma WHO grade IV), lower WHO grade astrocytomas (grade II and III), and nontumor brain tissue.
  • With the use of a subset of 104 identified membrane proteins, the properties of intact protein fractionation in the first dimension of the semi-top-down approach were elucidated in detail.
  • The benefit of the semi-top-down approach was further demonstrated by the identification of a set of endogenous glioblastoma multiforme expressed proteins.
  • The results indicate the usefulness of the semi-top-down approach for the investigation of immunogenic antigens in human tumor tissue samples.
  • [MeSH-minor] Antigens, Neoplasm. Brain Chemistry. Humans. Isoelectric Point. Male. Membrane Proteins / chemistry. Middle Aged. Molecular Weight. Peptides / analysis. Proteins / analysis. Reproducibility of Results

  • Genetic Alliance. consumer health - Glioblastoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19673542.001).
  • [ISSN] 1535-3907
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Membrane Proteins; 0 / Peptides; 0 / Proteins; 0 / Proteome
  •  go-up   go-down


98. Kim NR, Chung DH, Lee SK, Ha SY: Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings. J Korean Med Sci; 2007 Sep;22 Suppl:S149-53
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell ependymoma was included in the World Health Organization classification of the nervous system in 1993, and all the reported cases, except for two in the spinal cord, were located in the brain, mainly in the supratentorial compartment.
  • Astrocytomas outnumber ependymomas in the spinal cord, and the two entities partly share cytologic findings such as long, bipolar glial processes and oval to round nuclei resembling those seen in pilocytic astrocytoma.
  • On hematoxylin-eosin stain, oval to round tumor cells had large central nuclei with indistinct nucleoli and a moderate amount of clear cytoplasm, i.e. perinuclear halo, mimicking oligodendroglioma.

  • Genetic Alliance. consumer health - Ependymoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer. 2003 Nov 15;98(10):2232-44 [14601094.001]
  • [Cites] Acta Neuropathol. 1983;62(1-2):141-4 [6659872.001]
  • [Cites] Am J Surg Pathol. 1997 Jul;21(7):820-6 [9236838.001]
  • [Cites] Acta Cytol. 1997 Nov-Dec;41(6):1726-31 [9390132.001]
  • [Cites] Neurol Res. 2003 Jun;25(4):324-8 [12870256.001]
  • [Cites] Neurosurgery. 2000 Dec;47(6):1434-7; discussion 1437-8 [11126915.001]
  • [Cites] Curr Neurol Neurosci Rep. 2003 May;3(3):193-9 [12691623.001]
  • [Cites] Pathol Int. 2003 May;53(5):297-302 [12713564.001]
  • [Cites] Acta Neuropathol. 2000 Feb;99(2):214-8 [10672330.001]
  • (PMID = 17923743.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2694393
  •  go-up   go-down


99. Styczynski J, Olszewska-Slonina D, Kolodziej B, Napieraj M, Wysocki M: Activity of bortezomib in glioblastoma. Anticancer Res; 2006 Nov-Dec;26(6B):4499-503
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Chemotherapy is the commonly accepted standard therapy for most types of brain tumor, especially in medulloblastoma, primitive neuroectodermal tumor and astrocytoma.
  • MATERIALS AND METHODS: Glioblastoma multiforme T98G, glioblastoma-astrocytoma U373M and T-lineage acute lymphoblastic leukemia CCRF-CEM cell lines were used.
  • [MeSH-minor] Bortezomib. Cell Line, Tumor. Humans

  • Genetic Alliance. consumer health - Glioblastoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • Hazardous Substances Data Bank. BORTEZOMIB .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17201170.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Pyrazines; 69G8BD63PP / Bortezomib
  •  go-up   go-down


100. Sadones J, Michotte A, Veld P, Chaskis C, Sciot R, Menten J, Joossens EJ, Strauven T, D'Hondt LA, Sartenaer D, Califice SF, Bierau K, Svensson C, De Grève J, Neyns B: MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma. Eur J Cancer; 2009 Jan;45(1):146-53
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.
  • AIMS: To investigate the correlation between O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and benefit from temozolomide in patients with recurrent high-grade glioma.
  • RESULTS: A subgroup of 38 patients who were chemotherapy-naive at recurrence was analysed (22 glioblastoma, 12 anaplastic astrocytoma [AA] and 4 anaplastic oligoastrocytoma [AOA]); none had 1p/19q loss.
  • Among 10 (26%) patients with a hypermethylated MGMT promoter, none experienced disease progression within the first two treatment cycles compared with 12 of 28 (43%) patients with an unmethylated promoter (p=0.016).
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Astrocytoma / drug therapy. Brain Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. O(6)-Methylguanine-DNA Methyltransferase / genetics. Promoter Regions, Genetic
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. DNA Methylation. Female. Glioblastoma / drug therapy. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality. Prognosis. Retrospective Studies. Survival Rate. Young Adult

  • Genetic Alliance. consumer health - Glioblastoma.
  • Genetic Alliance. consumer health - Anaplastic Astrocytoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. DACARBAZINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18945611.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
  •  go-up   go-down






Advertisement