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1
astrocytic glioma 2005:2010[pubdate] *count=100
2863 results
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Items 1 to 100 of about 2863
1.
Sekula RF Jr, Marchan EM, Quigley MR, Frederickson AM, Pu C:
A case of an elderly adult presenting with obstructive hydrocephalus secondary to a rare hemorrhagic suprasellar pilocytic astrocytoma.
Clin Neuropathol
; 2008 Nov-Dec;27(6):396-9
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[Title]
A case of an elderly adult presenting with obstructive hydrocephalus secondary to a rare hemorrhagic suprasellar pilocytic
astrocytoma
.
Urgent surgery was performed and final pathology eventuated a pilocytic
astrocytoma
.
Although rare cases of suprasellar pilocytic
astrocytoma
in children and adults have been reported, we report an interesting case
of a
hemorrhagic suprasellar pilocytic
astrocytoma
in an elderly adult (without prior anticoagulant use) causing impending brain herniation secondary to obstructive hydrocephalus.
[MeSH-major]
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Cerebral Hemorrhage / etiology. Hydrocephalus / etiology
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(PMID = 19130737.001).
[ISSN]
0722-5091
[Journal-full-title]
Clinical neuropathology
[ISO-abbreviation]
Clin. Neuropathol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Germany
2.
Zhao YC, Li NY, Zhou XJ:
[Updates on clinicopathologic researches of pilocytic astrocytoma].
Zhonghua Bing Li Xue Za Zhi
; 2007 Dec;36(12):846-8
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[Title]
[Updates on clinicopathologic researches of pilocytic
astrocytoma
].
[MeSH-major]
Astrocytoma
/ diagnosis.
Astrocytoma
/ pathology
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(PMID = 18346360.001).
[ISSN]
0529-5807
[Journal-full-title]
Zhonghua bing li xue za zhi = Chinese journal of pathology
[ISO-abbreviation]
Zhonghua Bing Li Xue Za Zhi
[Language]
chi
[Publication-type]
Journal Article; Review
[Publication-country]
China
[Number-of-references]
25
3.
Hu W, Shen F, Chen G, Shen G, Liu W, Zhou J:
Possible involvement of brain tumour stem cells in the emergence of a fast-growing malignant meningioma after surgical resection and radiotherapy of high-grade astrocytoma: case report and preliminary laboratory investigation.
J Int Med Res
; 2009 Jan-Feb;37(1):240-6
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[Title]
Possible involvement of brain tumour stem cells in the emergence
of a
fast-growing malignant meningioma after surgical resection and radiotherapy of high-grade
astrocytoma
: case report and preliminary laboratory investigation.
The case
of a
62-year old man diagnosed with radiation-induced meningioma (RIM) after treatment
for astrocytoma
with an unusually short latency period of 7 months is reported.
Gross total resection was performed and the tumour was confirmed to be an
astrocytoma
.
A rare fraction of brain tumour stem cells (BTSC) was isolated from the primary
astrocytoma
using a serum-free culture system, suggesting that BTSC may have been involved in the rapid emergence of RIM after resection and radiation of the primary
astrocytoma
.
[MeSH-major]
Astrocytoma
/ radiotherapy.
Astrocytoma
/ surgery. Brain Neoplasms / pathology. Brain Neoplasms / secondary. Meningioma / pathology. Meningioma / secondary. Neoplastic Stem Cells / pathology
[MeSH-minor]
Combined Modality Therapy.
Disease
Progression. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Time Factors.
Tumor
Cells, Cultured
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(PMID = 19215696.001).
[ISSN]
0300-0605
[Journal-full-title]
The Journal of international medical research
[ISO-abbreviation]
J. Int. Med. Res.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
Advertisement
4.
Scholz M, Lorenz A, Pesavento A, Brendel B, Khaled W, Engelhardt M, Pechlivanis I, Noack V, Harders A, Schmieder K:
Current status of intraoperative real-time vibrography in neurosurgery.
Ultraschall Med
; 2007 Oct;28(5):493-7
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The aim of the present study was to test the application of vibrography during brain
tumor
surgery.
MATERIALS AND METHODS: The real-time vibrography system consisted
of a
conventional ultrasound system (Siemens Sonoline Omnia) with a custom-designed RF interface and a 6.5-MHz endocavity curved array (Siemens 6.5EC10).
In one patient minimal bleeding of the cortical surface occurred in a frontobasal
tumor
; however, no postoperative deficits were noted.
In low-grade
astrocytomas
and oligodendrogliomas, this additional technique can be used to control resection.
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.
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(PMID = 17918047.001).
[ISSN]
0172-4614
[Journal-full-title]
Ultraschall in der Medizin (Stuttgart, Germany : 1980)
[ISO-abbreviation]
Ultraschall Med
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
5.
Huang CX, Liu YS, Hou YH:
[Detection and clinical significance of urinary epidermal growth factor in brain tumor patients].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 2006 Apr;31(2):268-70
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[Title]
[Detection and clinical significance of urinary epidermal growth factor in brain
tumor
patients].
METHODS: The levels of EGF in urine samples collected from 20 patients (9 low grade
astrocytomas
, 6 anaplastic
astrocytomas
, and 5 meningiomas) and 5 healthy individuals were determined.
RESULTS: Preoperative urinary EGF levels
of astrocytoma
patients were statistically higher than those of meningioma patients and the controls (P < 0.01).
Preoperative urinary EGF levels showed a positive correlation with the degree of malignance in the
astrocytoma
patients (P < 0.05).
A significant decrease of the postoperative levels of EGF was observed in the
astrocytoma
patients who underwent gross total resection (P < 0.01).
CONCLUSION: The urinary EGF levels
of astrocytoma
patients correlate with the WHO grade of malignance and significantly decrease after gross total removal.
Urinary EGF may be of practical value in diagnosing and evaluating the surgical efficacy
of astrocytomas
.
[MeSH-major]
Astrocytoma
/ urine. Biomarkers,
Tumor
/ urine. Brain Neoplasms / urine. Epidermal Growth Factor / urine
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(PMID = 16706130.001).
[ISSN]
1672-7347
[Journal-full-title]
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
[ISO-abbreviation]
Zhong Nan Da Xue Xue Bao Yi Xue Ban
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
[Chemical-registry-number]
0 / Biomarkers, Tumor; 62229-50-9 / Epidermal Growth Factor
6.
Vital AL, Tabernero MD, Castrillo A, Rebelo O, TĂŁo H, Gomes F, Nieto AB, Resende Oliveira C, Lopes MC, Orfao A:
Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology.
Neuro Oncol
; 2010 Sep;12(9):991-1003
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[Title]
Gene expression profiles of human glioblastomas are associated with both
tumor
cytogenetics and histopathology.
Despite the increasing knowledge about the genetic alterations and molecular pathways involved in
gliomas
, few studies have investigated the association between the gene expression profiles (GEP) and both cytogenetics and histopathology
of gliomas
.
Here, we analyzed the GEP (U133Plus2.0 chip) of 40
gliomas
(35
astrocytic
tumors, 3 oligodendrogliomas, and 2 mixed tumors) and their association with
tumor
cytogenetics and histopathology.
Unsupervised and supervised analyses showed significantly different GEP in low- vs high-grade
gliomas
, the most discriminating genes including genes involved in the regulation of cell proliferation, apoptosis, DNA repair, and signal transduction.
In turn, among glioblastoma multiforme (GBM), 3 subgroups of tumors were identified according to their GEP, which were closely associated with the cytogenetic profile of their ancestral
tumor
cell clones: (i) EGFR amplification, (ii) isolated trisomy 7, and (iii) more complex karyotypes.
In summary, our results show a clear association between the GEP
of gliomas
and
tumor
histopathology; additionally, among grade IV
astrocytoma
, GEP are significantly associated with the cytogenetic profile of the ancestral
tumor
cell clone.
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.
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[
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]
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Neurogenetics. 2010 May;11(2):227-39
[
19760258.001
]
(PMID = 20484145.001).
[ISSN]
1523-5866
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2940695
7.
Marsh J, Mukherjee P, Seyfried TN:
Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma.
Clin Cancer Res
; 2008 Dec 1;14(23):7751-62
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[Title]
Akt-dependent proapoptotic effects of dietary restriction on late-stage management
of a
phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse
astrocytoma
.
PURPOSE: Malignant
astrocytomas
exhibit constitutive Akt phosphorylation due to reduced phosphatase and tensin homologue (PTEN)
tumor
suppressor expression or to increased growth factor receptor tyrosine kinase activation.
Many
astrocytomas
are also tuberous sclerosis complex 2 (TSC2) protein deficient and exhibit constitutive mammalian target of rapamycin (mTOR) activity.
Astrocytomas
harboring PTEN/Akt/TSC2 pathway mutations are dependent on glycolysis to satisfy their bioenergetic requirements.
Therapies that disrupt energy homeostasis can potentially manage
astrocytoma
growth and progression.
Although dietary restriction (DR) reduces glycolysis and manages early-stage
astrocytoma
growth, no prior studies have identified the mechanisms involved or determined if DR can also manage late-stage
tumor
growth.
EXPERIMENTAL DESIGN: The effects
of a
late-onset intermittent DR feeding paradigm were examined in adult C57BL/6J mice bearing the syngeneic CT-2A malignant
astrocytoma
grown orthotopically or subcutaneously.
DR initiated 10 to 14 days after
tumor
implantation (late onset) reduced CT-2A growth, delayed malignant progression, and significantly extended survival.
CONCLUSIONS: Our findings indicate that IGF-I/Akt signaling is associated with the antiapoptotic and glycolytic phenotype of the CT-2A
astrocytoma
and that DR targets this pathway.
Our findings highlight the efficacy of late-onset DR in managing
astrocytoma
growth and suggest that DR may be an effective broad-spectrum inhibitor of Akt signaling in PTEN/TSC2-deficient
astrocytomas
.
[MeSH-major]
Astrocytoma
/ diet therapy. Brain Neoplasms / diet therapy. PTEN Phosphohydrolase / deficiency. Proto-Oncogene Proteins c-akt / metabolism.
Tumor
Suppressor Proteins / deficiency
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(PMID = 19047102.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA102135; United States / NINDS NIH HHS / NS / NS 055195
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Tumor Suppressor Proteins; 4JG2LF96VF / tuberous sclerosis complex 2 protein; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.67 / PTEN Phosphohydrolase
8.
Parhar P, Ezer R, Shao Y, Allen JC, Miller DC, Newcomb EW:
Possible association of p53 codon 72 polymorphism with susceptibility to adult and pediatric high-grade astrocytomas.
Brain Res Mol Brain Res
; 2005 Jun 13;137(1-2):98-103
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[Title]
Possible association of p53 codon 72 polymorphism with susceptibility to adult and pediatric high-grade
astrocytomas
.
Polymorphisms in codon 72 of the p53
tumor
suppressor gene have been associated with susceptibility to human cancer.
In this study, we scored 135 brain
tumor
samples (92 adult and 43 pediatric cases consisting of 64 high-grade
astrocytomas
and 71 non-
astrocytomas
) for the P53 Arg72Pro polymorphisms.
(ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade
astrocytomas
compared with non-
astrocytomas
(P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade
astrocytomas
containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002).
Our results suggest a possible association between P53 Arg72Pro polymorphisms and susceptibility to brain tumors, particularly high-grade
astrocytomas
.
[MeSH-major]
Astrocytoma
/ genetics. Brain Neoplasms / genetics. Codon / genetics. Genetic Predisposition to
Disease
/ genetics. Polymorphism, Genetic / genetics.
Tumor
Suppressor Protein p53 / genetics
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(PMID = 15950766.001).
[ISSN]
0169-328X
[Journal-full-title]
Brain research. Molecular brain research
[ISO-abbreviation]
Brain Res. Mol. Brain Res.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / 5 U10 CA13539-29; United States / NCI NIH HHS / CA / CA90290
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Codon; 0 / Tumor Suppressor Protein p53
9.
Sanders RP, Kocak M, Burger PC, Merchant TE, Gajjar A, Broniscer A:
High-grade astrocytoma in very young children.
Pediatr Blood Cancer
; 2007 Dec;49(7):888-93
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[Title]
High-grade
astrocytoma
in very young children.
BACKGROUND: High-grade
astrocytomas
are rare in young children, but have been reported to have a better prognosis than similar tumors in older patients.
PROCEDURE: We retrospectively reviewed the clinical characteristics, survival, and long-term sequelae for patients younger than 3 years old with high-grade
astrocytoma
, treated at a single institution between 1984 and 2005.
Histology included anaplastic
astrocytoma
(n = 9), glioblastoma multiforme (n = 5), and malignant
glioma
(n = 2).
Six patients received scheduled irradiation and six were irradiated at the time
of disease
progression.
CONCLUSIONS: Young children with high-grade
astrocytoma
have better long-term overall survival than older patients, but recurrence is common, and most children require irradiation.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Astrocytoma
/ therapy. Brain Neoplasms / therapy
[MeSH-minor]
Age Factors. Child, Preschool.
Disease
Progression. Female. Follow-Up Studies. Humans. Infant. Male. Neuropsychological Tests. Predictive Value of Tests. Prognosis. Recurrence. Retrospective Studies. Survival Rate. Treatment Outcome
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[Copyright]
2007 Wiley-Liss, Inc
[CommentIn]
Pediatr Blood Cancer. 2007 Dec;49(7):879-80
[
17941062.001
]
(PMID = 17554787.001).
[ISSN]
1545-5009
[Journal-full-title]
Pediatric blood & cancer
[ISO-abbreviation]
Pediatr Blood Cancer
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA 21765
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
10.
Honma S, Saito M, Kikuchi H, Saito Y, Oshima Y, Nakahata N, Yoshida M:
A reduction of epidermal growth factor receptor is involved in brefelamide-induced inhibition of phosphorylation of ERK in human astrocytoma cells.
Eur J Pharmacol
; 2009 Aug 15;616(1-3):38-42
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[Title]
A reduction of epidermal growth factor receptor is involved in brefelamide-induced inhibition of phosphorylation of ERK in human
astrocytoma
cells.
We found that brefelamide has a potent inhibitory growth effect measured by MTT assay in 1321N1 human
astrocytoma
cells.
These results suggest that one of the mechanisms of action of brefelamide is assumed to be inhibition of phosphorylation of ERK through a reduction of EGF receptor activity in 1321N1 human
astrocytoma
cells.
[MeSH-major]
Amides / pharmacology. Antineoplastic Agents / pharmacology.
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology. Phenols / pharmacology. Receptor, Epidermal Growth Factor / metabolism
[MeSH-minor]
Animals. Cell Line,
Tumor
. Cell Proliferation / drug effects. Epidermal Growth Factor / pharmacology. Extracellular Signal-Regulated MAP Kinases / metabolism. Gene Expression Regulation, Neoplastic / drug effects. Humans. Phosphorylation / drug effects. Signal Transduction / drug effects. Tyrosine / metabolism
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(PMID = 19559020.001).
[ISSN]
1879-0712
[Journal-full-title]
European journal of pharmacology
[ISO-abbreviation]
Eur. J. Pharmacol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Amides; 0 / Antineoplastic Agents; 0 / Phenols; 0 / brefelamide; 42HK56048U / Tyrosine; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
11.
Maiti AK, Ghosh K, Chatterjee U, Chakrobarti S, Chatterjee S, Basu S:
Epidermal growth factor receptor and proliferating cell nuclear antigen in astrocytomas.
Neurol India
; 2008 Oct-Dec;56(4):456-62
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[Title]
Epidermal growth factor receptor and proliferating cell nuclear antigen in
astrocytomas
.
AIMS: The involvement of various growth factors, growth factor receptors and proliferative markers in the molecular pathogenesis of
astrocytic
neoplasms are being studied extensively.
Since EGFR and proliferating cell nuclear antigen (PCNA) are involved in mitogenic signal transduction and cellular proliferation pathway, we have studied the correlation between the expression of EGFR and PCNA labeling index in
astrocytic
tumors.
MATERIALS AND METHODS: We investigated the immunohistochemical expression of EGFR and PCNA using the appropriate monoclonal antibodies in 40 cases of
astrocytic
tumors of which 21 cases were glioblastoma, eight cases were Grade III or anaplastic
astrocytomas
and six cases were Grade II or diffuse
astrocytomas
and five cases were Grade I or pilocytic
astrocytomas
.
RESULTS: Both the EGFR expression and PCNA labeling index increase with increasing grades
of astrocytomas
with a significantly high percentage of cells showing positive staining for both EGFR and PCNA in GBM and Grade III
astrocytomas
compared to Grade II
astrocytomas
.
The expression levels of both EGFR and PCNA were low in Grade I or pilocytic
astrocytomas
.
CONCLUSIONS: A significant correlation was found between EGFR overexpression and PCNA labeling index in Grade III and Grade II
astrocytomas
and glioblastoma.
These suggest that the
tumor
proliferation, at least in higher grades
of astrocytomas
is dependent in some measure on EGF and EGFR-related signaling pathways.
[MeSH-major]
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Proliferating Cell Nuclear Antigen / metabolism. Receptor, Epidermal Growth Factor / metabolism
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(PMID = 19127042.001).
[ISSN]
0028-3886
[Journal-full-title]
Neurology India
[ISO-abbreviation]
Neurol India
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
India
[Chemical-registry-number]
0 / Proliferating Cell Nuclear Antigen; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
12.
Lacoste-Collin L, d'Aure D, Aziza J, Quintyn ML, Uro-Coste E, Courtade-SaĂŻdi M:
Cerebrospinal fluid cytologic findings of a pleomorphic xanthoastrocytoma: a case report.
Acta Cytol
; 2010 Sep-Oct;54(5 Suppl):871-4
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[Title]
Cerebrospinal fluid cytologic findings
of a
pleomorphic xanthoastrocytoma: a case report.
BACKGROUND: Pleomorphic xanthoastrocytoma (PXA) is a rare
astrocytic
neoplasm
with a relatively favorable prognosis.
Characteristic histologic features include pleomorphic
tumor
cells and lipidized cells expressing glial fibrillary acidic protein (GFAP), corresponding to a World Health Organization grade 2
tumor
.
Computed tomography of the central nervous system revealed a supracallous periventricular
tumor
mass suggestive of either a lymphoma or a metastatic carcinoma.
CSF revealed 18 cells/mm3 and contained numerous
tumor
cells highly pleomorphic in size and shape.
A primitive glial proliferation was found, and paraffin-embedded
tumor
tissue obtained by biopsy confirmed the diagnosis of anaplastic PXA.
[MeSH-major]
Astrocytoma
/ cerebrospinal fluid.
Astrocytoma
/ pathology. Brain Neoplasms / cerebrospinal fluid. Brain Neoplasms / pathology
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(PMID = 21053559.001).
[ISSN]
0001-5547
[Journal-full-title]
Acta cytologica
[ISO-abbreviation]
Acta Cytol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
13.
Essig M, Rohrer M, Giesel F, TĂŒttenberg J, Weber MA, Michaely H, Gerigk L, Voth M:
Human brain tumor imaging with a protein-binding MR contrast agent: initial experience.
Eur Radiol
; 2010 Jan;20(1):218-26
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[Title]
Human brain
tumor
imaging with a protein-binding MR contrast agent: initial experience.
In one nonenhancing low grade
astrocytoma
an enhancing nodule became visible only 5 h after gadofosvesest injection.
As shown in this initial report, contrast-enhanced intracranial
tumor
imaging is possible with the protein-binding blood pool agent gadofosveset.
The agent gives a significant
tumor
contrast in early postcontrast imaging comparable with conventional agents.
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(PMID = 19672603.001).
[ISSN]
1432-1084
[Journal-full-title]
European radiology
[ISO-abbreviation]
Eur Radiol
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Blood Proteins; 0 / Contrast Media; 0 / Organometallic Compounds; AU0V1LM3JT / Gadolinium; XM33Q67UVH / gadofosveset trisodium
14.
Wolff JE, Berrak S, Koontz Webb SE, Zhang M:
Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.
J Neurooncol
; 2008 May;88(1):57-63
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[Title]
Nitrosourea efficacy in high-grade
glioma
: a survival gain analysis summarizing 504 cohorts with 24193 patients.
Even though past studies have suggested efficacy of nitrosourea drugs in patients with high-grade
glioma
and temozolomide has recently been shown significantly to be beneficial, no conclusive comparisons between these agents have been published.
We performed a survival gain analysis of 364 studies describing 24,193 patients with high-grade
glioma
treated in 504 cohorts, and compared the effects of drugs.
The most frequent diagnoses were glioblastoma multiforme (GBM) (72%) and anaplastic
astrocytoma
(22%).
This information allowed the calculation
of a
predicted mOS for each cohort based on their prognostic factors independent of treatment.
[MeSH-major]
Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy.
Glioma
/ drug therapy. Nitrosourea Compounds / therapeutic use
[MeSH-minor]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Astrocytoma
/ drug therapy.
Astrocytoma
/ pathology. Carmustine / adverse effects. Carmustine / therapeutic use. Clinical Trials as Topic. Cohort Studies. Data Interpretation, Statistical. Databases, Factual. Female. Glioblastoma / drug therapy. Glioblastoma / pathology. Humans. Lomustine / adverse effects. Lomustine / therapeutic use. Male. Nimustine / adverse effects. Nimustine / therapeutic use. Reproducibility of Results. Selection Bias. Survival Analysis. Treatment Outcome
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[
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[
12697871.001
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N Engl J Med. 2005 Mar 10;352(10 ):987-96
[
15758009.001
]
(PMID = 18253699.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA 16672
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Nitrosourea Compounds; 0S726V972K / Nimustine; 7BRF0Z81KG / Lomustine; U68WG3173Y / Carmustine
15.
Mobasheri MB, Jahanzad I, Mohagheghi MA, Aarabi M, Farzan S, Modarressi MH:
Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features.
Cancer Detect Prev
; 2007;31(4):296-302
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METHODS: In this study expression of TSGA10 and SYCP3 were investigated in different cancers (156
tumor
samples) using RT-PCR.
But, SYCP3 transcripts were found in four
tumor
samples (moderately differentiated gemistocytic
astrocytoma
, pituitary adenoma,
glioma
and an ovarian
tumor
).
[MeSH-major]
Biomarkers,
Tumor
/ genetics. Gene Expression. Neoplasms / genetics. Neoplasms / pathology. Nuclear Proteins / genetics. Proteins / genetics
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(PMID = 17920210.001).
[ISSN]
0361-090X
[Journal-full-title]
Cancer detection and prevention
[ISO-abbreviation]
Cancer Detect. Prev.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Proteins; 0 / SYCP3 protein, human; 0 / TSGA10 protein, human
16.
Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K:
Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells.
J Neurochem
; 2007 Oct;103(1):259-75
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The neurotrophin receptor tropomyosin-related kinase A (TrkA) and its ligand nerve growth factor (NGF) are expressed in
astrocytomas
, and an inverse association of TrkA expression with malignancy grade was described.
[MeSH-minor]
Cell Line,
Tumor
. Enzyme Activation / drug effects. Extracellular Signal-Regulated MAP Kinases / metabolism. Gene Transfer Techniques. Humans. JNK Mitogen-Activated Protein Kinases / metabolism. Nerve Growth Factor / pharmacology. Vacuoles / ultrastructure
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(PMID = 17635673.001).
[ISSN]
0022-3042
[Journal-full-title]
Journal of neurochemistry
[ISO-abbreviation]
J. Neurochem.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
9061-61-4 / Nerve Growth Factor; EC 2.7.10.1 / Receptor, trkA; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases
17.
Zhou B, Phan V, Liu X, Juhasz A, Chu PG, Yen Y:
Production of a monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry study of human cancer tissues.
Hybridoma (Larchmt)
; 2006 Oct;25(5):264-70
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[Title]
Production
of a
monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry study of human cancer tissues.
We report production
of a
monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry (IHC) staining of human cancer tissues available in paraffin block.
No staining was identified on
astrocytoma
, mesothelioma, or myeloma.
[MeSH-minor]
Animals. Antigens,
Neoplasm
/ immunology. Breast Neoplasms / metabolism. Carcinoma / metabolism. Humans. Hybridomas / metabolism. Mice. Mice, Inbred BALB C. Oropharyngeal Neoplasms / metabolism. Reverse Transcriptase Polymerase Chain Reaction / methods. Ribonucleotide Reductases / immunology
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(PMID = 17044781.001).
[ISSN]
1554-0014
[Journal-full-title]
Hybridoma (2005)
[ISO-abbreviation]
Hybridoma (Larchmt)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; EC 1.17.4.- / Ribonucleotide Reductases; EC 1.17.4.- / ribonucleotide reductase M2; EC 1.17.4.1 / Ribonucleoside Diphosphate Reductase
18.
Tamiya T, Takao S, Ichikawa T, Chayama K, Date I:
Successful chemotherapy for congenital malignant gliomas: a report of two cases.
Pediatr Neurosurg
; 2006;42(4):240-4
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[Title]
Successful chemotherapy for congenital malignant
gliomas
: a report of two cases.
We describe the cases of 2 patients with a congenital malignant
glioma
that responded to chemotherapy.
A T(1)-weighted gadolinium-enhanced magnetic resonance image showed a large
tumor
in his right frontal lobe.
The
tumor
was partially resected, and the histological diagnosis was malignant ganglioglioma.
The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual
tumor
shrank.
The
tumor
was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide).
The
tumor
has not recurred in more than 8.5 years.
The T(1)-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar
tumor
.
The
tumor
was partially resected, and the histological diagnosis was anaplastic
astrocytoma
.
The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the
tumor
has not recurred in more than 7.5 years.
Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant
gliomas
in neonates and infants, long-term survival is possible.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Astrocytoma
/ therapy. Brain Neoplasms / therapy. Ganglioglioma / therapy
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[Copyright]
Copyright (c) 2006 S. Karger AG, Basel.
(PMID = 16714866.001).
[ISSN]
1016-2291
[Journal-full-title]
Pediatric neurosurgery
[ISO-abbreviation]
Pediatr Neurosurg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Nitrosourea Compounds; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; RYH2T97J77 / ranimustine
19.
Buckle MJ, Ellis RW, Bone M, Lockman H:
Neurologically presenting Whipple disease: case report and review of the literature.
J Clin Pathol
; 2008 Oct;61(10):1140-1
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[Title]
Neurologically presenting Whipple
disease
: case report and review of the literature.
A previously healthy male with subacute onset right leg weakness was suspected to have an
astrocytoma
as imaging showed a lesion.
Subsequent biopsy showed the presence of foamy macrophages containing periodic acid-Schiff staining granules, suggesting Whipple
disease
as a possible diagnosis.
[MeSH-major]
Spinal
Diseases
/ pathology. Whipple
Disease
/ pathology
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consumer health - Spine Injuries and Disorders
.
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(PMID = 18381382.001).
[ISSN]
1472-4146
[Journal-full-title]
Journal of clinical pathology
[ISO-abbreviation]
J. Clin. Pathol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Anti-Bacterial Agents; 75J73V1629 / Ceftriaxone; 8064-90-2 / Trimethoprim, Sulfamethoxazole Drug Combination
[Number-of-references]
5
20.
Katakowski M, Jiang F, Zheng X, Gutierrez JA, Szalad A, Chopp M:
Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17.
Cancer Sci
; 2009 Sep;100(9):1597-604
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EGFR is a key component of autonomous growth signaling in several tumors, and correlates with the malignancy grade
of astrocytoma
.
When implanted in the nude mouse brain, CTX-TNA2 cells induced low histological grade, benign intraventricular
gliomas
.
In contrast, the same astrocytes with hADAM17 formed large malignant
gliomas
.
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(PMID = 19515085.001).
[ISSN]
1349-7006
[Journal-full-title]
Cancer science
[ISO-abbreviation]
Cancer Sci.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA043892-17; United States / NCI NIH HHS / CA / R01 CA100486-04; United States / NCI NIH HHS / CA / P01 CA043892; United States / NCI NIH HHS / CA / CA100486-04; United States / NCI NIH HHS / CA / R01 CA100486; United States / NCI NIH HHS / CA / P01 CA043892-17
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
England
[Chemical-registry-number]
0 / Angiogenesis Inducing Agents; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.4.24.- / ADAM Proteins; EC 3.4.24.- / tumor necrosis factor-alpha convertase
[Other-IDs]
NLM/ NIHMS142282; NLM/ PMC2756136
21.
Mason WP:
Progress in clinical neurosciences: Advances in the management of low-grade gliomas.
Can J Neurol Sci
; 2005 Feb;32(1):18-26
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[Title]
Progress in clinical neurosciences: Advances in the management of low-grade
gliomas
.
The management of low-grade
gliomas
represents one of the most challenging and controversial areas in neuro-
oncology
.
Many aspects of the treatment of low-grade
gliomas
are debated, including the optimal timing of surgery and radiotherapy, the benefit of extensive surgery, and the impact of these variables on the natural history of these indolent and generally incurable tumours.
The recognition that as many as two thirds of low-grade
gliomas
have oligodendroglial features, advances in molecular diagnostics making accurate pathologic diagnosis of oligodendroglial tumours possible, and the established chemosensitivity of malignant oligodendrogliomas, have raised new issues surrounding the potential value of chemotherapy for low-grade
gliomas
.
This review will be restricted to low-grade diffuse
astrocytomas
, oligodendrogliomas, and low-grade mixed oligoastrocytomas in adults, and provide evidence-based guidelines for the management of these tumours, including the emerging role of chemotherapy as initial treatment.
[MeSH-major]
Brain Neoplasms.
Glioma
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(PMID = 15825542.001).
[ISSN]
0317-1671
[Journal-full-title]
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
[ISO-abbreviation]
Can J Neurol Sci
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Canada
[Number-of-references]
74
22.
Regan EM, Uney JB, Dick AD, Zhang Y, Nunez-Yanez J, McGeehan JP, Claeyssens F, Kelly S:
Differential patterning of neuronal, glial and neural progenitor cells on phosphorus-doped and UV irradiated diamond-like carbon.
Biomaterials
; 2010 Jan;31(2):207-15
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In the present study we complement and extend these findings by exploring patterning of dorsal root ganglion (DRG) explants, human neural progenitor cells (hNPC) and U-87
astroglioma
cells on P:DLC.
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(PMID = 19833386.001).
[ISSN]
1878-5905
[Journal-full-title]
Biomaterials
[ISO-abbreviation]
Biomaterials
[Language]
eng
[Grant]
United Kingdom / Wellcome Trust / /
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
27YLU75U4W / Phosphorus; 7782-40-3 / Diamond
23.
Poliani PL, Sperli D, Valentini S, Armentano A, Bercich L, Bonetti MF, Corriero G, Brisigotti M, Quattrone A, Lanza PL:
Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case.
Neuropathology
; 2009 Oct;29(5):574-8
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[Title]
Spinal glioneuronal
tumor
with neuropil-like islands and meningeal dissemination: histopathological and radiological study
of a
pediatric case.
In the present report we describe a case
of a
15-month-old child with a spinal GTNI of the cervical region and meningeal dissemination.
Histologically the
tumor
was composed of round, small neurocytic-like cells arranged around eosinophilic neuropil cores and embedded in a diffuse fibrillar glial component forming prominent "rosetted" neuropil islands displaying strong immunoreactivity for neuronal markers.
Cerebral GTNI shows abundant glial components not rarely exhibiting anaplastic features that justify their inclusion within the group of diffuse
astrocytomas
.
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(PMID = 19077041.001).
[ISSN]
1440-1789
[Journal-full-title]
Neuropathology : official journal of the Japanese Society of Neuropathology
[ISO-abbreviation]
Neuropathology
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
24.
Armand JP, Ribrag V, Harrousseau JL, Abrey L:
Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors.
Ther Clin Risk Manag
; 2007 Jun;3(2):213-24
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Procarbazine alone, or more commonly combined in the PCV (procarbazine, lomustine [CCNU], and vincristine) regimen, is also effective in treating
gliomas
comprising
astrocytomas
, glioblastomas, and oligodendrogliomas.
In conclusion, the use of procarbazine in combination with other drugs means that it remains a major anticancer drug in the management of Hodgkin's lymphoma and
gliomas
.
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]
(PMID = 18360630.001).
[ISSN]
1176-6336
[Journal-full-title]
Therapeutics and clinical risk management
[ISO-abbreviation]
Ther Clin Risk Manag
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
New Zealand
[Other-IDs]
NLM/ PMC1936303
25.
Shukla K, Parikh B, Shukla J, Trivedi P, Shah B:
Accuracy of cytologic diagnosis of central nervous system tumours in crush preparation.
Indian J Pathol Microbiol
; 2006 Oct;49(4):483-6
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The most common
tumor
in intracranial cavity was
astrocytoma
(56.68%), followed by meningioma (6.88%), medulloblastoma (5.66%) and ependymoma (5.56%).
The most common
tumor
in intraspinal cavity was ependymoma (38.46%), followed by meningioma (23.07%) and schwannoma (23.07%).
[MeSH-major]
Astrocytoma
. Central Nervous System Neoplasms / diagnosis. Cytodiagnosis. Ependymoma. Medulloblastoma. Meningioma. Neurilemmoma
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(PMID = 17183833.001).
[ISSN]
0377-4929
[Journal-full-title]
Indian journal of pathology & microbiology
[ISO-abbreviation]
Indian J Pathol Microbiol
[Language]
eng
[Publication-type]
Comparative Study; Evaluation Studies; Journal Article
[Publication-country]
India
26.
Choi WH, Ji KA, Jeon SB, Yang MS, Kim H, Min KJ, Shong M, Jou I, Joe EH:
Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation.
Biochem Biophys Res Commun
; 2005 Apr 1;329(1):125-31
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In primary cultured rat brain astrocytes and C6
astroglioma
cells, both cRA and tRA decreased IFN-gamma-induced expression of interferon regulatory factor-1.
Furthermore, the effect of pre-treated RA was abolished in the presence of cycloheximide, indicating a requirement
for de
novo protein synthesis.
Gene Ontology.
gene/protein/disease-specific - Gene Ontology annotations from this paper
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(PMID = 15721283.001).
[ISSN]
0006-291X
[Journal-full-title]
Biochemical and biophysical research communications
[ISO-abbreviation]
Biochem. Biophys. Res. Commun.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Anti-Inflammatory Agents; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / Protein Synthesis Inhibitors; 0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / STAT1 Transcription Factor; 0 / STAT3 Transcription Factor; 0 / Socs1 protein, rat; 0 / Socs3 protein, rat; 0 / Stat1 protein, rat; 0 / Stat3 protein, rat; 0 / Suppressor of Cytokine Signaling Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 5688UTC01R / Tretinoin; 82115-62-6 / Interferon-gamma; 98600C0908 / Cycloheximide; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / Jak1 protein, rat; EC 2.7.10.2 / Jak2 protein, rat; EC 2.7.10.2 / Janus Kinase 1; EC 2.7.10.2 / Janus Kinase 2
27.
Becher OJ, Peterson KM, Khatua S, Santi MR, MacDonald TJ:
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
J Child Neurol
; 2008 Oct;23(10):1205-13
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[Title]
IGFBP2 is overexpressed by pediatric malignant
astrocytomas
and induces the repair enzyme DNA-PK.
To identify targets critical to malignant childhood
astrocytoma
, we compared the expression of receptor tyrosine kinase- associated genes between low-grade and high-grade pediatric
astrocytomas
.
The highest differentially overexpressed gene in high-grade
astrocytoma
is insulin-like growth factor- binding protein-2 (P = .0006).
Insulin-like growth factor- binding protein-2 stimulation had no effect on
astrocytoma
cell growth and migration, and minimally inhibited insulin-like growth factor-1-mediated migration, but not insulin-like growth factor-2-mediated migration.
DNA-PKcs is also highly overexpressed by high-grade
astrocytomas
.
These findings suggest insulin-like growth factor-binding protein-2 plays a role in
astrocytoma
progression by promoting DNA-damage repair and therapeutic resistance.
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[
10764044.001
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11118044.001
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(PMID = 18952587.001).
[ISSN]
1708-8283
[Journal-full-title]
Journal of child neurology
[ISO-abbreviation]
J. Child Neurol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / K08 CA092056; United States / NINDS NIH HHS / NS / R13 NS040925; United States / NINDS NIH HHS / NS / 5R13NS040925-09; United States / NCI NIH HHS / CA / K08 CA92056-01
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Insulin-Like Growth Factor Binding Protein 2; 0 / Nuclear Proteins; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.11.1 / DNA-Activated Protein Kinase; EC 2.7.11.1 / PRKDC protein, human
[Other-IDs]
NLM/ NIHMS473094; NLM/ PMC3674842
28.
Ogura M, Nakamichi N, Takano K, Oikawa H, Kambe Y, Ohno Y, Taniura H, Yoneda Y:
Functional expression of A glutamine transporter responsive to down-regulation by lipopolysaccharide through reduced promoter activity in cultured rat neocortical astrocytes.
J Neurosci Res
; 2006 Jun;83(8):1447-60
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[Title]
Functional expression
of A
glutamine transporter responsive to down-regulation by lipopolysaccharide through reduced promoter activity in cultured rat neocortical astrocytes.
Moreover, LPS significantly inhibited the promoter activity of GlnT in the
astrocytic
cell line C6
glioma
cells as well as primary rat neocortical astrocytes in culture.
[MeSH-minor]
Animals. Animals, Newborn. Base Sequence. Cell Line,
Tumor
. Cell Membrane / drug effects. Cell Membrane / metabolism. Cells, Cultured. Encephalitis / chemically induced. Encephalitis / genetics. Encephalitis / metabolism. Endocytosis / drug effects. Endocytosis / physiology. Glutamic Acid / biosynthesis. Lipopolysaccharides / pharmacology. Molecular Sequence Data. Neocortex / cytology. RNA, Messenger / drug effects. RNA, Messenger / metabolism. Rats. Rats, Wistar
Hazardous Substances Data Bank.
GLUTAMIC ACID HYDROCHLORIDE
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[Copyright]
(c) 2006 Wiley-Liss, Inc.
(PMID = 16583402.001).
[ISSN]
0360-4012
[Journal-full-title]
Journal of neuroscience research
[ISO-abbreviation]
J. Neurosci. Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Amino Acid Transport System A; 0 / Carrier Proteins; 0 / Lipopolysaccharides; 0 / RNA, Messenger; 0 / Slc38a1 protein, rat; 0 / glutamine transport proteins; 3KX376GY7L / Glutamic Acid
29.
Harris JE, Friedland JS:
l-Glutamate in Middlebrook 7H9 culture medium upregulates matrix metalloproteinase-2 secretion from human astrocytoma cells.
J Neurosci Methods
; 2008 Aug 30;173(2):291-4
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[Title]
l-Glutamate in Middlebrook 7H9 culture medium upregulates matrix metalloproteinase-2 secretion from human
astrocytoma
cells.
Whilst investigating the secretion of MMP-2 from human U373-MG
astrocytoma
cells, we observed elevated MMP-2 secretion in response to Middlebrook 7H9 media but not to Mycobacterium tuberculosis itself.
Middlebrook 7H9 media did not stimulate MMP-1 or MMP-9 secretion from
astrocytoma
cells.
The excitatory neurotransmitter l-glutamate, at concentrations found in Middlebrook 7H9 media, induced significant
astrocytoma
MMP-2 secretion (p<0.05).
l-Glutamate-induced MMP-2 activity may contribute to neuropathology in various CNS
diseases
and may generate misleading data in pathogen studies where Middlebrook 7H9 is the culture medium.
[MeSH-minor]
Astrocytoma
. Cell Culture Techniques / standards. Cell Line,
Tumor
. Diagnostic Errors / prevention & control. Extracellular Matrix / drug effects. Extracellular Matrix / enzymology. Extracellular Matrix / microbiology. Humans. Mycobacterium tuberculosis / drug effects. Mycobacterium tuberculosis / enzymology. Reagent Kits, Diagnostic / standards. Up-Regulation / drug effects. Up-Regulation / physiology
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(PMID = 18611410.001).
[ISSN]
0165-0270
[Journal-full-title]
Journal of neuroscience methods
[ISO-abbreviation]
J. Neurosci. Methods
[Language]
eng
[Grant]
United Kingdom / Medical Research Council / /
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Culture Media; 0 / Reagent Kits, Diagnostic; 3KX376GY7L / Glutamic Acid; EC 3.4.24.24 / Matrix Metalloproteinase 2
30.
Likavcanovå K, Dobrota D, Liptaj T, Prónayovå N, Mlynårik V, Belan V, Galanda M, Béres A, De Riggo J:
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy.
Gen Physiol Biophys
; 2005 Sep;24(3):327-35
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[Title]
In vitro study of
astrocytic
tumour metabolism by proton magnetic resonance spectroscopy.
In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade
of astrocytoma
is associated with increased level of choline-containing compounds (Cho) and decreased levels
of N
-acetylaspartate (NAA) and creatine and phosphocreatine (Cr).
In this work, we studied the metabolism of
glioma
tumours by in vitro proton magnetic resonance spectroscopy (1H-MRS).
1H-MR spectra were recorded in vitro from perchloric acid extracts
of astrocytoma
(WHO II) and glioblastoma multiforme (WHO IV) samples.
We observed differences between
astrocytoma
and glioblastoma multiforme in the levels of Cho, alanine, lactate, NAA, and glutamate/glutamine.
In
astrocytoma
samples, we found higher MR signal of NAA and lower signal of Cho and alanine.
The NAA/Cr ratio was higher in
astrocytomas
than in glioblastomas multiforme.
[MeSH-major]
Astrocytes / pathology.
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Magnetic Resonance Spectroscopy / methods. Neoplasms / metabolism
[MeSH-minor]
Aspartic Acid / analogs & derivatives. Aspartic Acid / therapeutic use. Brain / metabolism. Brain / pathology. Choline / chemistry. Choline / pharmacology. Chromium / chemistry. Creatine / chemistry. Glioblastoma / chemistry. Glioblastoma / metabolism.
Glioma
/ pathology. Humans. In Vitro Techniques. Phosphocreatine / chemistry. Spectrophotometry
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(L)-ASPARTIC ACID
.
Hazardous Substances Data Bank.
CREATINE
.
Hazardous Substances Data Bank.
CHOLINE CHLORIDE
.
Hazardous Substances Data Bank.
CHROMIUM, ELEMENTAL
.
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(PMID = 16308427.001).
[ISSN]
0231-5882
[Journal-full-title]
General physiology and biophysics
[ISO-abbreviation]
Gen. Physiol. Biophys.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Slovakia
[Chemical-registry-number]
020IUV4N33 / Phosphocreatine; 0R0008Q3JB / Chromium; 30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; MU72812GK0 / Creatine; N91BDP6H0X / Choline
31.
Kanamori M, Kawaguchi T, Nigro JM, Feuerstein BG, Berger MS, Miele L, Pieper RO:
Contribution of Notch signaling activation to human glioblastoma multiforme.
J Neurosurg
; 2007 Mar;106(3):417-27
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OBJECT: Because activation of Notch receptors has been suggested to be critical for Ras-mediated transformation, and because many
gliomas
exhibit deregulated Ras signaling, the authors measured Notch levels and activation in primary samples and cell lines derived from glioblastoma multiforme (GBM) as well as the contribution of Notch pathway activation to
astrocytic
transformation and growth.
CONCLUSIONS: Notch activation contributes to Ras-induced transformation of glial cells and to
glioma
growth, survival, or both and as such may represent a new target for GBM therapy.
[MeSH-minor]
Astrocytes / metabolism. Case-Control Studies. Cell Line,
Tumor
. Humans. RNA, Messenger / metabolism
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[CommentIn]
J Neurosurg. 2007 Nov;107(5):1060-1; author reply 1061-2
[
17977283.001
]
(PMID = 17367064.001).
[ISSN]
0022-3085
[Journal-full-title]
Journal of neurosurgery
[ISO-abbreviation]
J. Neurosurg.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA 100011; United States / NCI NIH HHS / CA / CA94989; United States / NCI NIH HHS / CA / CA97257
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / RNA, Messenger; 0 / Receptors, Notch
32.
Hamada H, Kurimoto M, Hayashi N, Nagai S, Kurosaki K, Nomoto K, Kanegane H, Nomura K, Endo S:
Pilomyxoid astrocytoma in a patient presenting with fatal hemorrhage. Case report.
J Neurosurg Pediatr
; 2008 Mar;1(3):244-6
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[Title]
Pilomyxoid
astrocytoma
in a patient presenting with fatal hemorrhage. Case report.
The authors report on a rare case of pilomyxoid
astrocytoma
in a patient presenting with fatal hemorrhage.
Because the pathological diagnosis was pilomyxoid
astrocytoma
, chemotherapy was administered.
In this report, the authors review the literature and discuss the clinical features and treatment of pilomyxoid
astrocytoma
.
[MeSH-major]
Astrocytoma
/ diagnosis. Brain Neoplasms / diagnosis. Cerebral Hemorrhage / diagnosis
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(PMID = 18352771.001).
[ISSN]
1933-0707
[Journal-full-title]
Journal of neurosurgery. Pediatrics
[ISO-abbreviation]
J Neurosurg Pediatr
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
United States
[Number-of-references]
19
33.
Rashid MH, Ahmad SU, Rahman MH, Raihan MZ, Sayed MA:
Surgical outcome of low grade astrocytoma of brain.
Mymensingh Med J
; 2010 Apr;19(2):185-90
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[Title]
Surgical outcome of low grade
astrocytoma of
brain.
This study was carried out in the department of Neurosurgery, Dhaka Medical College Hospital, Dhaka, Bangladesh, during the period of January 2003 to December 2006 to elucidate the effectiveness of surgical treatment in the management of low grade
astrocytoma of
brain.
For this purpose, a total number of 50 cases admitted during the study period with low grade
astrocytoma of
brain supported by clinical features and radiological investigations (CT and MRI scan) were included in this study.
Out of 50 patients 60.0% had gross total removal
of tumor
and 40.0% sub total
tumor
resection.
Histopathological study was done in all cases after
tumor
resection.
Among the gross total
tumor
removal cases highest percentage had good recovery (93.4%) in the immediate post operative period.
Another 2(4.0%), those underwent subtotal
tumor
resection died during subsequent follow up period at 8th and 14th postoperative day.
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(PMID = 20395910.001).
[ISSN]
1022-4742
[Journal-full-title]
Mymensingh medical journal : MMJ
[ISO-abbreviation]
Mymensingh Med J
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
Bangladesh
[Chemical-registry-number]
0 / Contrast Media
34.
Giffoni SD, Cendes F, Valente M, Gil-da-Silva-Lopes VL:
Midline facial defects with hypertelorism and low-grade astrocytoma: a previously undescribed association.
Cleft Palate Craniofac J
; 2006 Nov;43(6):748-51
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[Title]
Midline facial defects with hypertelorism and low-grade
astrocytoma
: a previously undescribed association.
We report on a child with midline facial defects with hypertelorism (MFDH), median cleft lip, sphenoidal ventriculocele, partial agenesis of the corpus callosum, and low-grade
astrocytoma
in the cervicomedullary junction.
[MeSH-major]
Astrocytoma
/ complications. Brain Neoplasms / complications. Craniofacial Abnormalities / complications. Hypertelorism / complications
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(PMID = 17105323.001).
[ISSN]
1055-6656
[Journal-full-title]
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
[ISO-abbreviation]
Cleft Palate Craniofac. J.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
35.
Koul D:
PTEN signaling pathways in glioblastoma.
Cancer Biol Ther
; 2008 Sep;7(9):1321-5
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Malignant
gliomas
are the most common primary brain
tumor
in adults, but the prognosis for patients with these tumors remains poor despite advances in diagnosis and standard therapies such as surgery, radiation therapy, and chemotherapy.
Progress in the treatment
of gliomas
now depends to a great extent on an increased understanding of the biology of these tumors.
Recent insights into the biology
of gliomas
include the
finding
that tyrosine kinase receptors and signal transduction pathways play a role in
tumor
initiation and maintenance.
Deregulation of phosphatidylinositol 3-kinase (PI3K) signaling pathways resulting from genetic alterations in the PTEN
tumor
suppressor gene on 10q23 at the level of LOH, mutation and methylation have been identified in at least 60% of glioblastoma.
Loss of PTEN function by mutation or LOH correlates with poor survival in anaplastic
astrocytoma
and glioblastoma, suggesting that PTEN plays a role in patient outcome.
Interestingly, amplification of Epidermal growth factor receptor (EGFR) in the background of heterozygous PTEN knockout mice develop invasive
glioma
very similar to human glioblastoma, demonstrating the importance of PTEN in
glioma
progression and providing a model system to evaluate the efficacy of targeting PTEN in glioblastoma.
[MeSH-major]
Brain Neoplasms / genetics. Glioblastoma / genetics. PTEN Phosphohydrolase / genetics. Signal Transduction / physiology.
Tumor
Suppressor Proteins / physiology
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(PMID = 18836294.001).
[ISSN]
1555-8576
[Journal-full-title]
Cancer biology & therapy
[ISO-abbreviation]
Cancer Biol. Ther.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Tumor Suppressor Proteins; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
[Number-of-references]
60
36.
Rickert CH, Riemenschneider MJ, Schachenmayr W, Richter HP, Bockhorn J, Reifenberger G, Paulus W:
Glioblastoma with adipocyte-like tumor cell differentiation--histological and molecular features of a rare differentiation pattern.
Brain Pathol
; 2009 Jul;19(3):431-8
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[Title]
Glioblastoma with adipocyte-like
tumor
cell differentiation--histological and molecular features
of a
rare differentiation pattern.
We report on three adult patients with primary glioblastomas showing prominent adipocytic (lipomatous) differentiation, hence referred to as "glioblastomas with adipocyte-like
tumor
cell differentiation."
Histologically, the tumors demonstrated typical features of glioblastoma but additionally contained areas consisting of glial fibrillary acidic protein (GFAP)-positive
astrocytic
tumor
cells resembling adipocytes, that is, containing large intracellular lipid vacuoles.
The second
tumor
showed gains of chromosomes 3, 4, 8q and 12 as well as losses of chromosomes 10, 13, 15q, 19 and 22.
In addition, this
tumor
carried homozygous deletions of CDKN2A and p14(ARF) as well as point mutations in the TP53 and PTEN genes.
The third
tumor
also had a mutation in the PTEN gene.
Taken together, our results define a rare glioblastoma differentiation pattern and indicate that glioblastomas with adipocyte-like
tumor
cell differentiation share common molecular genetic features with other primary glioblastomas.
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(PMID = 18691268.001).
[ISSN]
1750-3639
[Journal-full-title]
Brain pathology (Zurich, Switzerland)
[ISO-abbreviation]
Brain Pathol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Switzerland
37.
Baurand A, Eckly A, Hechler B, Kauffenstein G, Galzi JL, Cazenave JP, Léon C, Gachet C:
Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?
Mol Pharmacol
; 2005 Mar;67(3):721-33
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In the present study, we investigated the desensitization and trafficking of the P2Y1 and P2Y12 receptors after agonist-induced stimulation of platelets or
astrocytoma
cells transfected with the P2Y1 or P2Y12 receptors fused to green fluorescent protein.
[MeSH-minor]
Adenosine Diphosphate / pharmacology. Amino Acid Sequence.
Astrocytoma
. Cell Line,
Tumor
. Cell Membrane / physiology. Cyclic AMP / metabolism. Humans. Microscopy, Confocal. Molecular Sequence Data. Peptide Fragments / chemistry. Receptors, Purinergic P2Y1. Receptors, Purinergic P2Y12. Recombinant Fusion Proteins / metabolism. Transfection
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(PMID = 15602005.001).
[ISSN]
0026-895X
[Journal-full-title]
Molecular pharmacology
[ISO-abbreviation]
Mol. Pharmacol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Membrane Proteins; 0 / P2RY1 protein, human; 0 / P2RY12 protein, human; 0 / Peptide Fragments; 0 / Receptors, Purinergic P2; 0 / Receptors, Purinergic P2Y1; 0 / Receptors, Purinergic P2Y12; 0 / Recombinant Fusion Proteins; 61D2G4IYVH / Adenosine Diphosphate; E0399OZS9N / Cyclic AMP
38.
Ishii D, Natsume A, Wakabayashi T, Hatano H, Asano Y, Takeuchi H, Shimato S, Ito M, Fujii M, Yoshida J:
Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant gliomas.
Neurol Med Chir (Tokyo)
; 2007 Aug;47(8):341-9; discussion 350
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[Title]
Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant
gliomas
.
Promoter methylation of the deoxyribonucleic acid (DNA) repair gene, O(6)-methylguanine-DNA methyltransferase (MGMT), is associated with improved outcome of patients with glioblastoma multiforme and anaplastic
astrocytoma
treated with temozolomide (TMZ).
Molecular genetic analysis of loss of heterozygosity (LOH) of 1p, 19q, or 10q, p53 mutation, and MGMT promoter methylation was performed in 44 assessable
tumor
specimens obtained from 46 patients with recurrent malignant
gliomas
, including 21 with glioblastoma multiforme, 17 with anaplastic
astrocytoma
, and eight with anaplastic oligoastrocytoma, which have heterogeneous features and variable histological diagnosis, to assess the correlation with the response to TMZ.
LOH of 1p in the heterogeneous population of malignant
gliomas
may be one of the important factors besides MGMT methylation that predict better outcome in patients treated with TMZ.
[MeSH-major]
Brain Neoplasms / genetics. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Dacarbazine / analogs & derivatives. Drug Resistance,
Neoplasm
/ genetics.
Glioma
/ genetics. Mutation / genetics.
Tumor
Suppressor Proteins / genetics
[MeSH-minor]
Adolescent. Adult. Aged. Antineoplastic Agents, Alkylating / pharmacology. Antineoplastic Agents, Alkylating / therapeutic use. Biomarkers,
Tumor
/ analysis. Biomarkers,
Tumor
/ metabolism. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. DNA Methylation. DNA Mutational Analysis. DNA Repair / genetics. Female. Genetic Markers / genetics. Genetic Predisposition to
Disease
/ genetics. Genetic Testing. Humans. Loss of Heterozygosity / genetics. Male. Middle Aged. Promoter Regions, Genetic / genetics. Survival Rate
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(PMID = 17721049.001).
[ISSN]
0470-8105
[Journal-full-title]
Neurologia medico-chirurgica
[ISO-abbreviation]
Neurol. Med. Chir. (Tokyo)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0 / Biomarkers, Tumor; 0 / Genetic Markers; 0 / Tumor Suppressor Proteins; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
39.
Brozzi F, Arcuri C, Giambanco I, Donato R:
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH.
J Biol Chem
; 2009 Mar 27;284(13):8797-811
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[Title]
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND
TUMOR
GROWTH.
We show here that reducing S100B levels in the
astrocytoma
cell line GL15 and the MĂŒller cell line MIO-M1 by small interference RNA technique results in a rapid disassembly of stress fibers, collapse of F-actin onto the plasma membrane and reduced migration, and acquisition
of a
stellate shape.
These results suggest that S100B might contribute to reduce the differentiation potential of cells of the
astrocytic
lineage and participate in the astrocyte activation process in the case of brain insult and in invasive properties of
glioma
cells.
[MeSH-major]
Astrocytes / metabolism.
Astrocytoma
/ metabolism. Cell Movement. Cell Shape. Nerve Growth Factors / metabolism. S100 Proteins / metabolism. src-Family Kinases / metabolism
[MeSH-minor]
Animals. Bucladesine / pharmacology. Cell Line,
Tumor
. Glycogen Synthase Kinase 3 / genetics. Glycogen Synthase Kinase 3 / metabolism. Humans. Phosphatidylinositol 3-Kinases / genetics. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / genetics. Proto-Oncogene Proteins c-akt / metabolism. RNA, Small Interfering / genetics. Rats. S100 Calcium Binding Protein beta Subunit. Stress Fibers / genetics. Stress Fibers / metabolism. Stroke / genetics. Stroke / metabolism. rac1 GTP-Binding Protein / genetics. rac1 GTP-Binding Protein / metabolism. rhoA GTP-Binding Protein / genetics. rhoA GTP-Binding Protein / metabolism
Gene Ontology.
gene/protein/disease-specific - Gene Ontology annotations from this paper
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[
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]
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Annu Rev Cell Dev Biol. 2005;21:247-69
[
16212495.001
]
(PMID = 19147496.001).
[ISSN]
0021-9258
[Journal-full-title]
The Journal of biological chemistry
[ISO-abbreviation]
J. Biol. Chem.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Nerve Growth Factors; 0 / RAC1 protein, human; 0 / RNA, Small Interfering; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins; 0 / S100B protein, human; 0 / S100b protein, rat; 124671-05-2 / RHOA protein, human; 63X7MBT2LQ / Bucladesine; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.2 / src-Family Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3; EC 3.6.1.- / Rac1 protein, rat; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / rhoA GTP-Binding Protein
[Other-IDs]
NLM/ PMC2659238
40.
Ishihara R, Katayama Y, Watanabe T, Yoshino A, Fukushima T, Sakatani K:
Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas.
Neurol Med Chir (Tokyo)
; 2007 Feb;47(2):53-7; discussion 57
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[Title]
Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating
astrocytomas
.
The fluorescence of protoporphyrin IX (PpIX) induced endogenously by 5-aminolevulinic acid (5-ALA) administration has recently been used for the intraoperative visualization of
glioma
tissues.
To increase the sensitivity of photodetection, the emission spectra of 5-ALA-induced PpIX fluorescence was quantitatively measured in tissues taken from six cases
of en
bloc resected diffusely infiltrating
astrocytomas
(2 diffuse
astrocytomas
, 2 anaplastic
astrocytomas
, and 2 glioblastomas), and the correlation assessed between the fluorescence intensity and histological features.
The ratio of the peak emission intensity to reflected excitation intensity or fluorescence intensity ratio was less than 0.001 for all 36 non-
tumor
tissues.
The MIB-1 proliferation index was the most powerful determinant, suggesting that higher cell proliferation may govern preferential PpIX accumulation in
glioma
cells.
This preliminary study suggests that spectroscopic analysis may be useful for optimizing the removal of diffuse
gliomas
.
[MeSH-major]
Astrocytoma
/ chemistry.
Astrocytoma
/ pathology. Brain Neoplasms / chemistry. Brain Neoplasms / pathology. Protoporphyrins / analysis
[MeSH-minor]
Aged. Aminolevulinic Acid. Female. Humans. Male. Middle Aged.
Neoplasm
Invasiveness. Photosensitizing Agents. Spectrometry, Fluorescence
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(PMID = 17317941.001).
[ISSN]
0470-8105
[Journal-full-title]
Neurologia medico-chirurgica
[ISO-abbreviation]
Neurol. Med. Chir. (Tokyo)
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Japan
[Chemical-registry-number]
0 / Photosensitizing Agents; 0 / Protoporphyrins; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
41.
Yamada K, Takeshima H, Sakurama T, Kuratsu J:
Secondary cervical dystonia following stereotactic radiosurgery in a patient with thalamic glioma.
Surg Neurol
; 2007 Dec;68(6):665-70
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[Title]
Secondary cervical dystonia following stereotactic radiosurgery in a patient with thalamic
glioma
.
We report the first patient with secondary CD after stereotactic radiosurgery for thalamic
glioma
.
CASE DESCRIPTION: A 27-year-old woman complaining of headache and left motor weakness was found to have a thalamic
tumor
on the right side.
Histopathologically,
tumor
samples manifested features of anaplastic
astrocytoma
.
[MeSH-major]
Brain Neoplasms / surgery.
Glioma
/ surgery. Postoperative Complications / etiology. Radiosurgery / adverse effects. Torticollis / etiology
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(PMID = 18053867.001).
[ISSN]
0090-3019
[Journal-full-title]
Surgical neurology
[ISO-abbreviation]
Surg Neurol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
42.
Sadetzki S, Zach L, Chetrit A, Nass D, Hoffmann C, Ram Z, Zaaroor M, Umansky F, Rappaport ZH, Cohen A, Wald U, Rothman S, Hadani M:
Epidemiology of gliomas in Israel: a nationwide study.
Neuroepidemiology
; 2008;31(4):264-9
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[Title]
Epidemiology
of gliomas
in Israel: a nationwide study.
This report presents the descriptive epidemiology of glial tumors by histological
subtype
and
tumor
behavior.
The majority of tumors (78%) were classified as high grade;
astrocytic
tumors were the most frequent (85%), with glioblastoma multiforme accounting for 70% of them.
To enhance our understanding of these
diseases
, epidemiological studies should rely on well-defined histological
tumor
types, incorporating comprehensive information which will allow comparability between different groups of patients.
[MeSH-major]
Brain Neoplasms / epidemiology.
Glioma
/ epidemiology. Jews / statistics & numerical data
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[Copyright]
Copyright 2008 S. Karger AG, Basel.
[CommentIn]
Neuroepidemiology. 2008;31(4):270
[
18931524.001
]
(PMID = 18931523.001).
[ISSN]
1423-0208
[Journal-full-title]
Neuroepidemiology
[ISO-abbreviation]
Neuroepidemiology
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
Switzerland
43.
Hales RK, Shokek O, Burger PC, Paynter NP, Chaichana KL, Quiñones-Hinojosa A, Jallo GI, Cohen KJ, Song DY, Carson BS, Wharam MD:
Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis.
J Neurooncol
; 2010 Aug;99(1):65-71
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[Title]
Prognostic factors in pediatric high-grade
astrocytoma
: the importance of accurate pathologic diagnosis.
To characterize a population of pediatric high-grade
astrocytoma
(HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria.
Log-rank analysis was used to compare survival by patient,
tumor
, and treatment factors.
Pathologic misdiagnosis should be suspected in patients who are long term survivors
of a
pediatric high grade
astrocytoma
.
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Cancer Res. 2006 Dec 1;66(23):11172-8
[
17145861.001
]
(PMID = 20043190.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
44.
Li M, Jia ZZ, Gu HM, Zhou XJ, Tang LM:
[Application of apparent diffusion coefficient and fractional anisotropy in identification of tumor component and grading of brain astrocytoma].
Zhonghua Yi Xue Za Zhi
; 2008 Dec 23;88(47):3352-5
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[Title]
[Application of apparent diffusion coefficient and fractional anisotropy in identification
of tumor
component and grading of brain
astrocytoma
].
OBJECTIVE: To evaluate the value of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in identification
of tumor
element and grading of brain
astrocytoma
.
METHODS: Thirty-three patients with histologically confirmed
astrocytoma
underwent diffusion weighted imaging (DWI), diffusion tensor imaging (DTI), and conventional MRI before operation.
The values of ADC and FA of different regions in the same
tumor
and
of astrocytoma
of different grades were measured and compared.
RESULTS: The ADC values of the
tumor
parenchyma, necrotic region, peritumoral edema region were (1.28 +/- 0.44), (1.97 +/- 0.53), and (1.74 +/- 0.47) respectively, all significantly higher than that of the corresponding normal brain tissues [(0.80 +/- 0.18), P = 0.009, P = 0.000, P = 0.000] with significantly differences between the
tumor
parenchyma and necrotic region and peritumoral edema region (both P < 0.05), however, there was not significant difference between the necrotic region and peritumoral edema region.
The FA values of the
tumor
parenchyma, necrotic region, and peritumoral edema region were (0.18 +/- 0.07), (0.14 +/- 0.05), and (0.16 +/- 0.05) respectively, all significantly higher than that of the corresponding normal brain tissues [(0.58 +/- 0.10), all P = 0.000], without significant differences among the former 3 groups.
There were no significant differences in the ADC and FA values among the tumors at different grades, however, there was a tendency of ADC to decrease and of FA to increase along the increase of grade
of tumor
, although not significantly.
CONCLUSION: ADC value plays an important part in distinguishing
tumor
components and determining
tumor
boundary, and plays a certain role in judging the grade
of astrocytomas
.
FA value is vital to determine the
tumor
boundary, and has certain value in differentiating high-grade from low-grade
astrocytomas
.
[MeSH-major]
Astrocytoma
/ pathology. Brain Neoplasms / pathology. Diffusion Magnetic Resonance Imaging / methods
[MeSH-minor]
Adolescent. Adult. Aged. Anisotropy. Female. Humans. Male. Middle Aged.
Neoplasm
Staging
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(PMID = 19257968.001).
[ISSN]
0376-2491
[Journal-full-title]
Zhonghua yi xue za zhi
[ISO-abbreviation]
Zhonghua Yi Xue Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
45.
Khalatbari M, Borghei-Razavi H, Shayanfar N, Behzadi AH, Sepehrnia A:
Collision tumor of meningioma and malignant astrocytoma.
Pediatr Neurosurg
; 2010;46(5):357-61
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[Title]
Collision
tumor of
meningioma and malignant
astrocytoma
.
The pathology of tumors reported collision tumors composed of meningioma and malignant
astrocytoma
.
[MeSH-major]
Astrocytoma
/ surgery. Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery
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[Copyright]
Copyright © 2011 S. Karger AG, Basel.
(PMID = 21389747.001).
[ISSN]
1423-0305
[Journal-full-title]
Pediatric neurosurgery
[ISO-abbreviation]
Pediatr Neurosurg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Switzerland
46.
Seyfried NT, Huysentruyt LC, Atwood JA 3rd, Xia Q, Seyfried TN, Orlando R:
Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach.
Cancer Lett
; 2008 May 18;263(2):243-52
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[Title]
Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse
astrocytoma
: a membrane proteomics approach.
Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain
tumor
origin and malignancy.
In this study, membrane proteins were identified from a terminally differentiated mouse astrocyte (AC) and CT-2A
astrocytoma
(CT-2A) cell line using liquid-chromatography coupled with tandem mass spectrometry (LC-MS/MS).
Therefore, our data suggest that the CT-2A
tumor
may be derived from NG2 glia rather than from fully differentiated astrocytes.
Moreover, the CT-2A cells also express a series of interferon-induced signature proteins that may be specific to this
tumor
.
These data highlight the utility of LC-MS/MS for the identification of brain
tumor
membrane biomarkers.
[MeSH-major]
Antigens / metabolism.
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Carrier Proteins / metabolism. Proteins / metabolism. Proteoglycans / metabolism. Proteomics
[MeSH-minor]
Animals. Biomarkers,
Tumor
/ analysis. Cell Line,
Tumor
. Cell Lineage. Chromatography, Liquid. Membrane Proteins / analysis. Mice. Tandem Mass Spectrometry. Up-Regulation
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Clin Immunol. 2006 Nov;121(2):159-76
[
16920030.001
]
[Cites]
Cancer Res. 2006 Nov 15;66(22):10815-23
[
17090523.001
]
[Cites]
Nature. 2006 Dec 7;444(7120):756-60
[
17051156.001
]
[Cites]
Mol Syst Biol. 2007;3:109
[
17486137.001
]
[Cites]
Brain Cell Biol. 2006 Jun;35(2-3):159-72
[
17957481.001
]
[Cites]
J Mol Biol. 2001 Jan 19;305(3):567-80
[
11152613.001
]
(PMID = 18281150.001).
[ISSN]
0304-3835
[Journal-full-title]
Cancer letters
[ISO-abbreviation]
Cancer Lett.
[Language]
eng
[Grant]
United States / NCRR NIH HHS / RR / P41 RR005351; United States / NCRR NIH HHS / RR / P41 RR005351; United States / NCRR NIH HHS / RR / P41 RR005351-20; United States / NCRR NIH HHS / RR / P41 RR018502
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Antigens; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Ifit1 protein, mouse; 0 / Ifit3 protein, mouse; 0 / Membrane Proteins; 0 / Proteins; 0 / Proteoglycans; 0 / chondroitin sulfate proteoglycan 4
[Other-IDs]
NLM/ NIHMS48651; NLM/ PMC2726046
47.
Cui XL, Zhao ZG, Ren XH, Sui DL, Chu JS, Tang K, Zeng C, Lin S:
[Characteristics of combining loss of heterozygosity of 1p/19q in glioma].
Zhonghua Wai Ke Za Zhi
; 2010 Jun 1;48(11):852-5
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[Title]
[Characteristics of combining loss of heterozygosity of 1p/19q in
glioma
].
METHODS: The status of 1p and 19q of 138
glioma
specimen from January 2009 to December 2009 was evaluated by Fluorescence in situ hybridization (FISH) method, and the frequencies of combining LOH of 1p/19q were compared between different pathologies, brain sub-regions, genders and ages.
RESULTS: The frequencies of combined LOH of 1p and 19q of oligodendroglial (81.3%) and oligo
astrocytic
tumors (55.8%) were significantly higher than that of
astrocytic
tumor
(22.2%) (P < 0.01), and the frequency of oligodendroglial
tumor
was significantly higher than that of oligo
astrocytic
tumor
(P < 0.05).
[MeSH-major]
Brain Neoplasms / genetics.
Glioma
/ genetics. Loss of Heterozygosity
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(PMID = 21163056.001).
[ISSN]
0529-5815
[Journal-full-title]
Zhonghua wai ke za zhi [Chinese journal of surgery]
[ISO-abbreviation]
Zhonghua Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
48.
Pusch L, Wegmann S, Caldwell JD, Jirikowski GF:
Expression of corticosteroid-binding globulin in human astrocytoma cell line.
Cell Mol Neurobiol
; 2009 Jun;29(4):583-8
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[Title]
Expression of corticosteroid-binding globulin in human
astrocytoma
cell line.
Glial
tumor
cells are known to be sensitive to glucocorticoids (GC) in vivo and in vitro.
Here we studied the expression of corticosteroid-binding globulin (CBG) in the low-grade malignant human
astrocytoma
cell line 1321N1.
[MeSH-major]
Astrocytoma
/ metabolism. Cell Line,
Tumor
. Transcortin / metabolism
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(PMID = 19172388.001).
[ISSN]
1573-6830
[Journal-full-title]
Cellular and molecular neurobiology
[ISO-abbreviation]
Cell. Mol. Neurobiol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Glucocorticoids; 0 / Insulin; 0 / NR3C1 protein, human; 0 / Receptors, Glucocorticoid; 7S5I7G3JQL / Dexamethasone; 9010-38-2 / Transcortin; WI4X0X7BPJ / Hydrocortisone
49.
Bergonzini V, Calistri A, Salata C, Del Vecchio C, Sartori E, Parolin C, PalĂč G:
Nef and cell signaling transduction: a possible involvement in the pathogenesis of human immunodeficiency virus-associated dementia.
J Neurovirol
; 2009 May;15(3):238-48
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Here we show that HIV-1 Nef has an effect on the transcriptional levels
of a
cellular protein, anaplastic lymphoma kinase (ALK), that is preferentially expressed in the central and peripheral nervous system at late embryonic stages.
By its overexpression along with Nef, the authors demonstrate ALK ability to influence, at least in the U87MG
astrocytic glioma
cells, the mytogen-activated protein kinase (MAP-K)-dependent pathway.
Moreover, although in the absence
of a
physical direct interaction, Nef and ALK activate matrix metalloproteinases (MMPs), which are likely to contribute to blood-brain barrier (BBB) damage in HAD.
[MeSH-minor]
Cell Line, Transformed. Cell Line,
Tumor
. Chemokine CCL5 / metabolism. Chemokine CXCL12 / metabolism. Humans. Receptor Protein-Tyrosine Kinases. Transcriptional Activation
HIV InSite.
treatment guidelines - Palliative Care of Patients with HIV
.
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[ISSN]
1538-2443
[Journal-full-title]
Journal of neurovirology
[ISO-abbreviation]
J. Neurovirol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / CXCL12 protein, human; 0 / Chemokine CCL5; 0 / Chemokine CXCL12; 0 / nef Gene Products, Human Immunodeficiency Virus; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
50.
Capper D, Zentgraf H, Balss J, Hartmann C, von Deimling A:
Monoclonal antibody specific for IDH1 R132H mutation.
Acta Neuropathol
; 2009 Nov;118(5):599-601
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IDH1 R132H mutations occur in approximately 70%
of astrocytomas
and oligodendroglial tumors.
Here, we show the high specificity and sensitivity of this antibody on Western blots and tissue sections from formalin fixed paraffin embedded
tumor
specimens.
This antibody is highly useful
for tumor classification
, in detecting single infiltrating
tumor
cells and for the characterization of the cellular role of mutant IDH1 protein.
[MeSH-minor]
Animals. Arginine / genetics.
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Histidine / genetics. Humans. Mice. Oligodendroglioma / metabolism. Sensitivity and Specificity
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[CommentIn]
Acta Neuropathol. 2009 Nov;118(5):603-4
[
19847448.001
]
(PMID = 19798509.001).
[ISSN]
1432-0533
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Mutant Proteins; 4QD397987E / Histidine; 94ZLA3W45F / Arginine; EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42. / IDH1 protein, human
51.
Doherty MJ, Hampson NB:
Partial seizure provoked by hyperbaric oxygen therapy: possible mechanisms and implications.
Epilepsia
; 2005 Jun;46(6):974-6
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We report a patient after resection of anaplastic
astrocytoma
and 5,580 cGy of total external-beam radiation treatments with brain radiation necrosis who underwent HBO2 therapy and developed a partial seizure during treatment.
[MeSH-minor]
Astrocytoma
/ radiotherapy.
Astrocytoma
/ surgery. Brain Neoplasms / radiotherapy. Brain Neoplasms / surgery. Combined Modality Therapy. Humans. Male. Middle Aged. Necrosis / etiology. Necrosis / pathology. Necrosis / therapy. Radiotherapy, Conformal / adverse effects
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(PMID = 15946345.001).
[ISSN]
0013-9580
[Journal-full-title]
Epilepsia
[ISO-abbreviation]
Epilepsia
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
52.
Chen AY, Lee H, Hartman J, Greco C, Ryu JK, O'Donnell R, Boggan J:
Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma.
AJNR Am J Neuroradiol
; 2005 Jan;26(1):160-2
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[Title]
Secondary supratentorial primitive neuroectodermal
tumor
following irradiation in a patient with low-grade
astrocytoma
.
We report a case
of a
supratentorial primitive neuroectodermal
tumor
(PNET) that occurred 12 years after cranial irradiation
for a
grade II
astrocytoma
.
Neuroimaging was unable to distinguish between a recurrence of the original
neoplasm
and the development
of a
new, distinct entity.
[MeSH-major]
Astrocytoma
/ radiotherapy. Brain Neoplasms / radiotherapy. Cranial Irradiation. Frontal Lobe. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neoplasms, Radiation-Induced / diagnosis. Neoplasms, Second Primary / diagnosis. Neuroectodermal Tumors, Primitive / diagnosis. Supratentorial Neoplasms / diagnosis. Tomography, X-Ray Computed
[MeSH-minor]
Adult. Biomarkers,
Tumor
/ analysis. Female. Follow-Up Studies. Glial Fibrillary Acidic Protein / analysis. Humans. Radiotherapy, Adjuvant. Synaptophysin / analysis
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(PMID = 15661719.001).
[ISSN]
0195-6108
[Journal-full-title]
AJNR. American journal of neuroradiology
[ISO-abbreviation]
AJNR Am J Neuroradiol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Synaptophysin
53.
Tchaicha JH, Mobley AK, Hossain MG, Aldape KD, McCarty JH:
A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis.
Oncogene
; 2010 Aug 5;29(31):4460-72
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[Title]
A mosaic mouse model
of astrocytoma
identifies alphavbeta8 integrin as a negative regulator
of tumor
angiogenesis.
Furthermore, little is known about how cancer cells selectively circumvent the actions of these inhibitors to promote pathological angiogenesis, a requisite event
for tumor
progression.
Using mosaic mouse models of the malignant brain cancer,
astrocytoma
, we report that
tumor
cells induce pathological angiogenesis by suppressing expression of the ECM protein receptor alphavbeta8 integrin.
Diminished integrin expression in
astrocytoma
cells leads to reduced activation of latent TGFbetas, resulting in impaired TGFbeta receptor signaling in
tumor
-associated endothelial cells.
These data reveal that
astrocytoma
cells manipulate their angiogenic balance by selectively suppressing alphavbeta8 integrin expression and function.
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[Cites]
Nature. 2006 Dec 7;444(7120):756-60
[
17051156.001
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[ISSN]
1476-5594
[Journal-full-title]
Oncogene
[ISO-abbreviation]
Oncogene
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P30 CA016672; United States / NINDS NIH HHS / NS / R01 NS059876-03; United States / NINDS NIH HHS / NS / R01NS059876; United States / NCI NIH HHS / CA / P50CA127001; United States / NINDS NIH HHS / NS / R01 NS059876-02S2; United States / NINDS NIH HHS / NS / R01 NS059876; United States / NCI NIH HHS / CA / P50 CA127001; United States / NINDS NIH HHS / NS / NS059876-03
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Integrins; 0 / integrin alphavbeta8
[Other-IDs]
NLM/ NIHMS198457; NLM/ PMC3037767
54.
Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT:
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.
Cancer Res
; 2005 Dec 15;65(24):11419-28
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[Title]
ABCC drug efflux pumps and organic anion uptake transporters in human
gliomas
and the blood-
tumor
barrier.
We therefore analyzed the expression and localization of six members of the multidrug resistance protein family of ATP-dependent efflux pumps (ABCC1-ABCC6, formerly MRP1-MRP6) and of six organic anion uptake transporters (OATP1A2, OATP1B1, OATP1B3, OATP1C1, OATP2B1, and OATP4A1) in 61 human
glioma
specimens of different histologic subtypes.
At the protein level, however, only OATP1A2 and OATP2B1 were detectable by immunofluorescence microscopy in the luminal membrane of endothelial cells forming the blood-brain barrier and the blood-
tumor
barrier, but not in the
glioma
cells.
ABCC4 and ABCC5 proteins were the major ABCC subfamily members in
gliomas
, localized both at the luminal side of the endothelial cells and in the
glioma
cells of
astrocytic
tumors and in the
astrocytic
portions of oligoastrocytomas.
These results indicate that expression of ABCC4 and ABCC5 is associated with an
astrocytic
phenotype, in accordance with their expression in astrocytes and with the higher chemoresistance of
astrocytic
tumors as compared with oligodendrogliomas.
Our data provide a basis for the assessment of the role of uptake transporters and efflux pumps in the accessibility of human
gliomas for
chemotherapeutic agents.
[MeSH-minor]
Adult. Aged.
Astrocytoma
/ drug therapy.
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology. Drug Resistance, Multiple. Drug Resistance,
Neoplasm
. Endothelium, Vascular / metabolism. Endothelium, Vascular / pathology. Female. Humans. Male. Membrane Transport Proteins / metabolism. Microscopy, Fluorescence. Middle Aged. Subcellular Fractions
MedlinePlus Health Information.
consumer health - Brain Tumors
.
The Lens.
Cited by Patents in
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(PMID = 16357150.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / ATP-Binding Cassette Transporters; 0 / Membrane Transport Proteins; 0 / Multidrug Resistance-Associated Proteins; 0 / Organic Anion Transporters
55.
Robe PA, Martin D, Albert A, Deprez M, Chariot A, Bours V:
A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668].
BMC Cancer
; 2006;6:29
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[Title]
A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant
gliomas
: study protocol of [ISRCTN45828668].
BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4
astrocytic glioma
remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen.
Indeed, the median survival of glioblastoma multiforme (WHO grade 4) patients is at best 14.6 month with only 26.5 percent of the patients still alive after 2 years and the median survival of anaplastic
astrocytomas
(WHO grade 3) is 19.2 month.
Recent evidence suggests that the transcription factor NF-kappaB is constitutively expressed in malignant
gliomas
and that its inhibition by drugs like Sulfasalazine may block the growth of
astrocytic
tumors in vitro and in experimental models of malignant
gliomas
.
A total of twenty patients with progressive malignant
glioma
despite surgery, radiation therapy and a first line of chemotherapy will be recruited and assigned to four dosage regimen of Sulfasalazine.
Primary endpoints are drug safety in the setting of malignant
gliomas
and
tumor
response as measured according to MacDonald's criteria.
DISCUSSION: The aim of this study is to evaluate the safety and efficacy of Sulfasalazine as a treatment for recurring malignant
gliomas
.
[MeSH-minor]
Administration, Oral. Adult. Aged. Brain Neoplasms.
Disease
Progression. Double-Blind Method. Female.
Glioma
. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Survival Analysis. Treatment Outcome
Hazardous Substances Data Bank.
SULFASALAZINE
.
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[Cites]
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[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Databank-accession-numbers]
ISRCTN/ ISRCTN45828668
[Publication-type]
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 3XC8GUZ6CB / Sulfasalazine
[Other-IDs]
NLM/ PMC1368982
56.
Burzynski SR:
Treatments for astrocytic tumors in children: current and emerging strategies.
Paediatr Drugs
; 2006;8(3):167-78
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[Title]
Treatments for
astrocytic
tumors in children: current and emerging strategies.
Despite these accomplishments, CNS tumors remain the leading cause of death in pediatric
oncology
.
Astrocytic
tumors form the most common histologic group among childhood brain tumors.
They are a heterogeneous group that from a practical therapeutic point of view can be subdivided into low-grade
astrocytomas
(LGA), optic pathway
gliomas
(OPG), high-grade
astrocytomas
(HGA), and brainstem
gliomas
(BSG).
Careful follow-up without any treatment is indicated
for a
small percentage of patients diagnosed with LGA with an indolent course including children with neurofibromatosis type 1 (NF1).
Radiation therapy is generally recommended for children with progressive LGA, or after failure of chemotherapy, accomplishing
tumor
control at 10 years in over 60% of patients.
OPG is the most common type of brain
tumor
associated with NF1.
Tumor
growth in some of these patients is slow with no treatment recommended for an extended period of time.
The prognosis for children with the remaining types
of astrocytomas
remains poor.
Careful evaluation of histology, location of the
tumor
, patient age, and consideration of treatment-related morbidity play an important part in selecting between clinical observation, surgery, radiation, chemotherapy, or investigational agents.
The goals of treatment for
astrocytic
tumors should extend well beyond objective responses and increased survival.
[MeSH-major]
Astrocytoma
/ therapy. Central Nervous System Neoplasms / therapy
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]
(PMID = 16774296.001).
[ISSN]
1174-5878
[Journal-full-title]
Paediatric drugs
[ISO-abbreviation]
Paediatr Drugs
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Switzerland
[Number-of-references]
155
57.
Adamson DC, Rasheed BA, McLendon RE, Bigner DD:
Central nervous system.
Cancer Biomark
; 2010;9(1-6):193-210
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The prognoses for these tumors are related to several factors, such as the age of the patient and the location and histology of the
tumor
.
Arising from glial cells,
gliomas
represent over 36% of all primary CNS tumors and consist
of astrocytomas
, oligodendrogliomas, ependymomas, mixed
gliomas
, and neuroepithelial tumors.
The most common
gliomas
are
astrocytomas
, and these tumors are typically classified by the World Health Organization (WHO) as Grades I through IV.
Grade IV, the most malignant grade
of astrocytoma
, includes glioblastoma multiforme (GBM), the most common malignant primary CNS
glioma
in adults, which represents 51% of all CNS
gliomas
.
Here we describe the molecular and cellular events associated with malignant
glioma
initiation and progression.
We also review the importance of
glioma
stem cell biology and
tumor
immunology in early gliomagenesis.
In addition, we present a brief description of the most common malignant primary CNS
glioma
in pediatric patients - medulloblastoma, as well as familial cancer syndromes that include
gliomas
as part of the syndrome.
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(PMID = 22112477.001).
[ISSN]
1875-8592
[Journal-full-title]
Cancer biomarkers : section A of Disease markers
[ISO-abbreviation]
Cancer Biomark
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Netherlands
58.
Rush SZ, Abel TW, Valadez JG, Pearson M, Cooper MK:
Activation of the Hedgehog pathway in pilocytic astrocytomas.
Neuro Oncol
; 2010 Aug;12(8):790-8
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[Title]
Activation of the Hedgehog pathway in pilocytic
astrocytomas
.
Pilocytic
astrocytoma
is commonly viewed as a benign lesion.
However,
disease
onset is most prevalent in the first two decades of life, and children are often left with residual or recurrent
disease
and significant morbidity.
The Hedgehog (Hh) pathway regulates the growth of higher WHO grade
gliomas
, and in this study, we have evaluated the activation and operational status of this regulatory pathway in pilocytic
astrocytomas
.
Expression levels of the Hh pathway transcriptional target PTCH were elevated in 45%
of tumor
specimens analyzed (ages 1-22 years) and correlated inversely with patient age.
Evaluation
of a
tissue array revealed oligodendroglioma-like features, pilomyxoid features, infiltration, and necrosis more commonly in specimens from younger patients (below the median patient age of 10 years).
Taken together, these findings suggest that Hh pathway activation is common in pediatric pilocytic
astrocytomas
and may be associated with younger age at diagnosis and
tumor
growth.
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Trends Pharmacol Sci. 2009 Jun;30(6):303-12
[
19443052.001
]
(PMID = 20223881.001).
[ISSN]
1523-5866
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P30 CA068485; United States / NINDS NIH HHS / NS / K02NS053614
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
England
[Chemical-registry-number]
0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 0 / Transcription Factors; 0 / patched receptors
[Other-IDs]
NLM/ PMC2940682
59.
Julow J, Szeifert GT, BĂĄlint K, NyĂĄry I, Nemes Z:
The role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral gliomas.
Neurol Res
; 2007 Apr;29(3):233-8
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[Title]
The role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral
gliomas
.
OBJECTIVE: To study histopathologic changes and the role of the microglia/macrophage cell in the therapeutic effect of I-125 interstitial brachytherapy on the cerebral
gliomas
.
METHODS: Out
of a
series of 60 cases with cerebral
astrocytomas
and other brain tumors treated with I-125 interstitial brachytherapy, autopsy materials were available in ten cases 0.75 and 60 months after irradiation.
The patients were treated with the maximum dosage (60 Gy) on the
tumor
periphery.
Besides the routine hematoxylin-eosine and Mallory's PTAH trichrome staining, immunohistochemical reactions were carried out for CD15, CD31, CD34, CD45, CD68, CPM, HAM56 and HLR-DR antigens on paraffin sections to study immunologic phenotypic characteristics of the reaction cell population around
gliomas
after I-125 treatment.
The reactive zone was characterized by
astrocytic
gliosis but vascular proliferation and macrophages were lacking.
The established phase of reactive zone around the necrotic center is characterized by a narrow inner rim of microglial accumulation and a broad outer area characterized by
astrocytic
gliosis, vascular proliferation, activated microglia and infiltration by macrophages.
In the burned-out phases of I-125 interstitial brachytherapy
of gliomas
, the necrosis undergoes liquefaction and the microglial rim is replaced by
astrocytic
gliosis which can be considered as equivalent to the scar tissue formed around necrosis outside the central nervous system.
[MeSH-major]
Brachytherapy / methods. Brain Neoplasms / pathology. Brain Neoplasms / radiotherapy.
Glioma
/ pathology.
Glioma
/ radiotherapy. Macrophages / radiation effects. Microglia / radiation effects
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(PMID = 17509220.001).
[ISSN]
0161-6412
[Journal-full-title]
Neurological research
[ISO-abbreviation]
Neurol. Res.
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Glial Fibrillary Acidic Protein; 0 / Iodine Radioisotopes; EC 5.4.2.2 / PGM1 protein, human; EC 5.4.2.2 / Phosphoglucomutase
60.
Shin JH, Kim SW, Lim CM, Jeong JY, Piao CS, Lee JK:
alphaB-crystallin suppresses oxidative stress-induced astrocyte apoptosis by inhibiting caspase-3 activation.
Neurosci Res
; 2009 Aug;64(4):355-61
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To investigate the functional significance of alphaB-crystallin induction in astrocytes, we generated a stable C6
astroglioma
cell line overexpressing alphaB-crystallin.
Furthermore, the repression of alphaB-crystallin expression by alphaB-crystallin siRNA transfection suppressed this protective effect, indicating that alphaB-crystallin is responsible for the protection against H2O2-induced apoptosis in C6
astroglioma
cells.
[MeSH-minor]
Animals. Cell Line,
Tumor
. Cytoprotection / physiology. Down-Regulation / physiology. Hydrogen Peroxide / toxicity. Neurodegenerative
Diseases
/ genetics. Neurodegenerative
Diseases
/ metabolism. Neurodegenerative
Diseases
/ physiopathology. Oxidants / toxicity. Protein Binding / physiology. RNA Interference / physiology. Rats. Transfection
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.
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(PMID = 19379782.001).
[ISSN]
1872-8111
[Journal-full-title]
Neuroscience research
[ISO-abbreviation]
Neurosci. Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Oxidants; 0 / alpha-Crystallin B Chain; BBX060AN9V / Hydrogen Peroxide; EC 3.4.22.- / Caspase 3
61.
Yang SH, Hong YK, Yoon SC, Kim BS, Lee YS, Lee TK, Lee KS, Jeun SS, Kim MC, Park CK:
Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant glioma.
Oncol Rep
; 2007 Jun;17(6):1359-64
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[Title]
Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant
glioma
.
We analyzed the clinical efficacy and toxicity of concurrent therapy as a first line modality for malignant
glioma
patients.
From 1998 to 2004, 39 patients, 22 with glioblastoma (GM), nine with anaplastic
astrocytoma
(AA), 7 with anaplastic oligodendroglioma (AO) and 1 with anaplastic oligodendro-
astrocytoma
(AOA) were enrolled in this study.
Modified concurrent chemoradiotherapy may be a feasible option for treating malignant
glioma
with acceptable toxicity.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / adverse effects. Brain Neoplasms / drug therapy.
Glioma
/ drug therapy
[MeSH-minor]
Adolescent. Adult. Aged. Chemotherapy, Adjuvant. Child. Combined Modality Therapy.
Disease
Progression.
Disease
-Free Survival. Female. Humans. Lomustine / administration & dosage. Lomustine / adverse effects. Male. Middle Aged. Procarbazine / administration & dosage. Procarbazine / adverse effects. Survival Analysis. Treatment Outcome. Vincristine / administration & dosage. Vincristine / adverse effects
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LOMUSTINE
.
Hazardous Substances Data Bank.
VINCRISTINE
.
Hazardous Substances Data Bank.
PROCARBAZINE
.
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(PMID = 17487391.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine
62.
Basto D, Trovisco V, Lopes JM, Martins A, Pardal F, Soares P, Reis RM:
Mutation analysis of B-RAF gene in human gliomas.
Acta Neuropathol
; 2005 Feb;109(2):207-10
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[Title]
Mutation analysis of B-RAF gene in human
gliomas
.
Gliomas
are the most frequent primary central nervous system tumors and the molecular mechanisms that underlie the development and progression of these tumors are far from being completely understood.
The purpose of this study was to clarify the incidence of B-RAF mutations and their possible relation with
tumor
progression in a series of 82 human
gliomas
, including 49
astrocytic
and 33 oligodendroglial tumors.
These data suggest that activating mutations of B-RAF are not a frequent event in
gliomas
; nevertheless, when present they are associated with high-grade malignant lesions.
[MeSH-major]
Glioma
/ genetics. Mutation. Proto-Oncogene Proteins B-raf / genetics
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(PMID = 15791479.001).
[ISSN]
0001-6322
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
63.
Ernst A, Hofmann S, Ahmadi R, Becker N, Korshunov A, Engel F, Hartmann C, Felsberg J, Sabel M, Peterziel H, Durchdewald M, Hess J, Barbus S, Campos B, Starzinski-Powitz A, Unterberg A, Reifenberger G, Lichter P, Herold-Mende C, Radlwimmer B:
Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival.
Clin Cancer Res
; 2009 Nov 1;15(21):6541-50
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[Title]
Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel
tumor
-relevant genes associated with survival.
PURPOSE: Glioblastoma spheroid cultures are enriched in
tumor
stem-like cells and therefore may be more representative of the respective primary tumors than conventional monolayer cultures.
We exploited the
glioma
spheroid culture model to find novel
tumor
-relevant genes.
Microarray-based gene expression analysis was applied to determine genes with differential expression compared with normal brain tissue and to nonneoplastic brain spheroids in
glioma
spheroid cultures.
Immunohistochemistry on tissue microarrays revealed that expression of AJAP1, EMP3, and PDPN was significantly associated with overall survival of
astrocytic glioma
patients.
CONCLUSION: We identified a set of novel candidate genes that likely play a role in glioblastoma pathogenesis and implicate AJAP1, EMP3, and PDPN as molecular markers associated with the clinical outcome of
glioma
patients.
[MeSH-minor]
Biomarkers,
Tumor
. Brain / metabolism. Cell Culture Techniques. Humans. Oligonucleotide Array Sequence Analysis.
Tumor
Cells, Cultured
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(PMID = 19861460.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
64.
Okamoto H, Mineta T, Ueda S, Nakahara Y, Shiraishi T, Tamiya T, Tabuchi K:
Detection of JC virus DNA sequences in brain tumors in pediatric patients.
J Neurosurg
; 2005 Apr;102(3 Suppl):294-8
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METHODS: Genomic DNA sequences were isolated from 62 brain tumors (32 medulloblastomas, 18 ependymomas, five choroid plexus papillomas, and seven pilocytic
astrocytomas
) and analyzed for the presence of JC virus DNA by Southern blot hybridization and direct sequencing.
None of the medulloblastomas or pilocytic
astrocytomas
contained JC virus DNA.
[MeSH-minor]
Antigens, Viral,
Tumor
/ genetics.
Astrocytoma
/ pathology.
Astrocytoma
/ virology. Base Sequence. Blotting, Southern. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / virology. Cerebral Ventricle Neoplasms / pathology. Cerebral Ventricle Neoplasms / virology. Child. Child, Preschool. Ependymoma / pathology. Ependymoma / virology. Female. Humans. Infant. Male. Medulloblastoma / pathology. Medulloblastoma / virology. Papilloma, Choroid Plexus / pathology. Papilloma, Choroid Plexus / virology. Polymerase Chain Reaction. Supratentorial Neoplasms / pathology. Supratentorial Neoplasms / virology
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(PMID = 15881753.001).
[ISSN]
0022-3085
[Journal-full-title]
Journal of neurosurgery
[ISO-abbreviation]
J. Neurosurg.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Viral, Tumor; 0 / DNA, Viral
65.
Hulleman E, Helin K:
Molecular mechanisms in gliomagenesis.
Adv Cancer Res
; 2005;94:1-27
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Glioma
, and in particular high-grade
astrocytoma
termed glioblastoma multiforme (GBM), is the most common primary
tumor of
the brain.
Modeling
of astrocytomas
by genetic manipulation of mice suggests that deregulation of the pathways that control gliogenesis during normal brain development, such as the differentiation of neural stem cells (NSCs) into astrocytes, might contribute to GBM formation.
Use of novel techniques including large-scale genomics and proteomics in combination with relevant mouse models will most likely provide novel insights into the molecular mechanisms underlying
glioma
formation and will hopefully lead to development of treatment modalities for GBM.
[MeSH-major]
Brain Neoplasms /
classification
. Brain Neoplasms / physiopathology.
Glioma
/
classification
. Signal Transduction / physiology
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(PMID = 16095998.001).
[ISSN]
0065-230X
[Journal-full-title]
Advances in cancer research
[ISO-abbreviation]
Adv. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
United States
[Number-of-references]
155
66.
Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland EC:
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.
Neoplasia
; 2005 Apr;7(4):356-68
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[Title]
mTOR promotes survival and
astrocytic
characteristics induced by Pten/AKT signaling in glioblastoma.
Combined activation of Ras and AKT leads to the formation of
astrocytic
glioblastoma multiforme (GBM) in mice.
We demonstrate here that loss of Pten is similar to AKT activation in the context of
glioma
formation in mice.
Blockade of mTOR results in regional apoptosis in these tumors and conversion in the character of surviving
tumor
cells from
astrocytoma
to oligodendroglioma.
These data suggest that mTOR activity is required for the survival of some cells within these GBMs, and mTOR appears required for the maintenance of
astrocytic
character in the surviving cells.
Furthermore, our study provides the first example of conversion between two distinct
tumor
types usually thought of as belonging to specific lineages, and provides evidence for signal transduction-mediated transdifferentiation between
glioma
subtypes.
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(PMID = 15967113.001).
[ISSN]
1522-8002
[Journal-full-title]
Neoplasia (New York, N.Y.)
[ISO-abbreviation]
Neoplasia
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / U01CA894134-1
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; 147336-22-9 / Green Fluorescent Proteins; 624KN6GM2T / temsirolimus; EC 2.7.- / Protein Kinases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.67 / PTEN Phosphohydrolase; W36ZG6FT64 / Sirolimus
[Other-IDs]
NLM/ PMC1501155
67.
Bartik P, Maglott A, Entlicher G, Vestweber D, Takeda K, Martin S, Dontenwill M:
Detection of a hypersialylated beta1 integrin endogenously expressed in the human astrocytoma cell line A172.
Int J Oncol
; 2008 May;32(5):1021-31
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[Title]
Detection
of a
hypersialylated beta1 integrin endogenously expressed in the human
astrocytoma
cell line A172.
Gliomas
are the most common deadly brain tumors.
As a potential new target, alpha5beta1 was investigated here in two human
astrocytoma
cell lines, A172 and U87MG.
Overexpression of the beta1 integrin subunit in A172 cells not only increased the hypersialylated form but also led to the appearance
of a
non-hypersialylated beta1 form also addressed to the cell surface.
[MeSH-major]
Antigens, CD29 / metabolism.
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Protein Processing, Post-Translational. Sialic Acids / metabolism
[MeSH-minor]
Cell Adhesion. Cell Line,
Tumor
. Cell Membrane / metabolism. Cell Proliferation. Dimerization. Fibronectins / metabolism. Glycosylation. Humans. Integrin alpha5 / metabolism. Integrin alpha5beta1 / antagonists & inhibitors. Integrin alpha5beta1 / metabolism. Propionates / pharmacology. Pyridines / pharmacology. Spiro Compounds / pharmacology. Transfection. Up-Regulation
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.
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(PMID = 18425328.001).
[ISSN]
1019-6439
[Journal-full-title]
International journal of oncology
[ISO-abbreviation]
Int. J. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Greece
[Chemical-registry-number]
0 / Antigens, CD29; 0 / Fibronectins; 0 / Integrin alpha5; 0 / Integrin alpha5beta1; 0 / Propionates; 0 / Pyridines; 0 / SJ749; 0 / Sialic Acids; 0 / Spiro Compounds
68.
Higgins SC, Pilkington GJ:
The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant glioma.
Anticancer Res
; 2010 Feb;30(2):391-7
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[Title]
The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant
glioma
.
BACKGROUND: In this investigation the effects of tricyclic drugs on cellular respiration were studied using the anaplastic
astrocytoma
cell line IPSB-18 by use
of a
Clark-type oxygen electrode which measured changes in cellular respiration rate (oxygen consumption), in a dose-response assay.
Overall, it appeared that clomipramine and its metabolite norclomipramine were the most potent inhibitors of cellular respiration in
glioma
cells over the concentration range 0.5-0.9 mM.
Dexamethasone was able to induce inhibition of cellular respiration both alone in
glioma
cells, and in combination with clomipramine, where it had an additive or synergistic effect, thereby increasing cell death.
CONCLUSION: The extensive research currently ongoing and previously reported regarding the use of clomipramine as a potential antineoplastic agent aimed at targeting the mitochondria
of gliomas
is promising.
[MeSH-major]
Antidepressive Agents, Tricyclic / pharmacology. Antineoplastic Agents, Hormonal / pharmacology.
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Cell Respiration / drug effects. Dexamethasone / pharmacology
[MeSH-minor]
Amitriptyline / pharmacology. Antineoplastic Combined Chemotherapy Protocols. Clomipramine / pharmacology. Doxepin / pharmacology. Humans. Oxygen Consumption / drug effects. Respiratory Rate.
Tumor
Cells, Cultured
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.
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.
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AMITRIPTYLINE HYDROCHLORIDE
.
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(PMID = 20332444.001).
[ISSN]
1791-7530
[Journal-full-title]
Anticancer research
[ISO-abbreviation]
Anticancer Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
0 / Antidepressive Agents, Tricyclic; 0 / Antineoplastic Agents, Hormonal; 1668-19-5 / Doxepin; 1806D8D52K / Amitriptyline; 7S5I7G3JQL / Dexamethasone; NUV44L116D / Clomipramine
69.
Lee JM, Kim SH, Lee JI, Ryou JY, Kim SY:
Acute comitant esotropia in a child with a cerebellar tumor.
Korean J Ophthalmol
; 2009 Sep;23(3):228-31
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[Title]
Acute comitant esotropia in a child with a cerebellar
tumor
.
We report a case of acute comitant esotropia in a child with a cerebellar
tumor
.
A 3-year-old boy was referred for management
of a
9 month history of acute acquired comitant esotropia.
The mass was completely excised and histological examination confirmed the diagnosis of pilocytic
astrocytoma
.
Therefore, acute onset comitant esotropia in a child can be the first sign
of a
cerebellar
tumor
, even without any other neurological signs and symptoms.
[MeSH-major]
Astrocytoma
/ complications. Cerebellar Neoplasms / complications. Esotropia / etiology
[MeSH-minor]
Acute
Disease
. Brain / pathology. Child, Preschool. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Oculomotor Muscles / surgery. Refraction, Ocular. Time Factors
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[ISSN]
2092-9382
[Journal-full-title]
Korean journal of ophthalmology : KJO
[ISO-abbreviation]
Korean J Ophthalmol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Korea (South)
[Other-IDs]
NLM/ PMC2739968
[Keywords]
NOTNLM ; Acute onset / Cerebellar tumor / Comitant esotropia
70.
Jin M, Komohara Y, Shichijo S, Yamanaka R, Nikawa J, Itoh K, Yamada A:
Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients.
Cancer Sci
; 2008 Aug;99(8):1656-62
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[Title]
Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce
glioma
-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+
glioma
patients.
In the present study, we examined the expression of the EphB6 variant (EphB6v) in a panel of brain
tumor
cell lines and glioblastoma tissues and we found that EphB6v was preferentially expressed in malignant brain tumors, such as glioblastomas and anaplastic
astrocytomas
.
The two EphB6v-derived peptides exhibited the ability to bind to human leukocyte antigen (HLA)-A0201 molecules, and each of them was able to induce cytotoxic T lymphocytes in vitro in the peripheral blood mononuclear cells of HLA-A2(+)
glioma
patients.
[MeSH-minor]
Astrocytoma
/ metabolism. Brain Neoplasms / metabolism. Case-Control Studies. Cell Line,
Tumor
. Gene Expression. Glioblastoma / metabolism. HLA-A Antigens. HLA-A2 Antigen. Hepatocytes. Humans
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(PMID = 18754880.001).
[ISSN]
1349-7006
[Journal-full-title]
Cancer science
[ISO-abbreviation]
Cancer Sci.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / HLA-A Antigens; 0 / HLA-A*02:01 antigen; 0 / HLA-A2 Antigen; EC 2.7.1.- / EPHB6 protein, human; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
71.
Spacca B, Mallucci C, Riordan A, Appleton R, Thorp N, Pizer B:
HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature.
Childs Nerv Syst
; 2007 Nov;23(11):1347-50
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[Title]
HSV encephalitis in a child with brain stem
glioma
: a rare complication of therapy. Case report and review of the neurosurgical literature.
CASE REPORT: A 13-year-old boy was diagnosed with an inoperable, biopsy-proven pontine grade II
astrocytoma
.
He made slow improvement but died 8 months after diagnosis from
tumor
progression.
[MeSH-major]
Astrocytoma
/ complications. Brain Stem Neoplasms / complications. Encephalitis, Herpes Simplex / etiology. Herpesvirus 1, Human. Radiotherapy / adverse effects
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.
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]
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N Engl J Med. 1986 Jan 16;314(3):144-9
[
3001520.001
]
[Cites]
Neurosurgery. 1999 Mar;44(3):633-5; discussion 635-6
[
10069600.001
]
[Cites]
Herpes. 2004 Jun;11 Suppl 2:57A-64A
[
15319091.001
]
(PMID = 17593375.001).
[ISSN]
0256-7040
[Journal-full-title]
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
[ISO-abbreviation]
Childs Nerv Syst
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antiviral Agents; X4HES1O11F / Acyclovir
[Number-of-references]
14
72.
Darendeliler F, Karagiannis G, Wilton P, Ranke MB, Albertsson-Wikland K, Anthony Price D, On Behalf Of The Kigs International Board:
Recurrence of brain tumours in patients treated with growth hormone: analysis of KIGS (Pfizer International Growth Database).
Acta Paediatr
; 2006 Oct;95(10):1284-90
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[Title]
Recurrence of brain tumours in patients treated with growth hormone: analysis of KIGS (Pfizer
International
Growth Database).
AIM: To analyse KIGS (Pfizer
International
Growth Database) with respect to tumour recurrence in patients with brain tumours.
METHODS: Data for tumour recurrence were analysed retrospectively in 1038 patients with craniopharyngiomas, 655 with medulloblastomas, 113 with ependymomas, 297 with germinomas, and 400 with
astrocytomas
or
gliomas
.
[MeSH-major]
Brain Neoplasms / drug therapy. Human Growth Hormone / therapeutic use.
Neoplasm
Recurrence, Local / epidemiology. Recombinant Proteins / therapeutic use
[MeSH-minor]
Adolescent.
Astrocytoma
/ drug therapy.
Astrocytoma
/ mortality.
Astrocytoma
/ radiotherapy.
Astrocytoma
/ surgery. Child. Child, Preschool. Combined Modality Therapy. Craniopharyngioma / drug therapy. Craniopharyngioma / mortality. Craniopharyngioma / radiotherapy. Craniopharyngioma / surgery.
Disease
-Free Survival. Ependymoma / drug therapy. Ependymoma / mortality. Ependymoma / radiotherapy. Ependymoma / surgery. Female. Germinoma / drug therapy. Germinoma / mortality. Germinoma / radiotherapy. Germinoma / surgery. Humans. Male. Medulloblastoma / drug therapy. Medulloblastoma / mortality. Medulloblastoma / radiotherapy. Medulloblastoma / surgery
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(PMID = 16982503.001).
[ISSN]
0803-5253
[Journal-full-title]
Acta paediatrica (Oslo, Norway : 1992)
[ISO-abbreviation]
Acta Paediatr.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Norway
[Chemical-registry-number]
0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone
73.
Jaing TH, Lin KL, Tsay PK, Hsueh C, Hung PC, Wu CT, Tseng CK:
Treatment of optic pathway hypothalamic gliomas in childhood: experience with 18 consecutive cases.
J Pediatr Hematol Oncol
; 2008 Mar;30(3):222-4
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[Title]
Treatment of optic pathway hypothalamic
gliomas
in childhood: experience with 18 consecutive cases.
The aim of this study was to present our 17-year experience (1989 to 2006) in the treatment of optic pathway/hypothalamic
gliomas
(OPHG) in 18 children younger than 17 years (median age, 66 mo).
Histologic studies showed low-grade
astrocytoma
(WHO grade I or II) in 16 cases, anaplastic
astrocytoma
in 1, and oligoastrocytoma (WHO grade III) in 1.
Treatment included partial
tumor
resection in 12 patients, chemotherapy in 5, and radiotherapy in 3.
All treatment modalities led to
tumor
shrinkage and stabilization
for a
variable period, but none of them totally eradicated the
tumor
.
Fourteen (78%) of 18 patients had a sustained reduction
of tumor
size between 6 months and 17 years.
Two patients died, none with neurofibromatosis-1, with a hypothalamic/chiasmatic
tumor
with suprasellar extension and accompanying electrolyte abnormalities.
Because progression of these tumors is slow and associated with endocrinopathy, we recommend chemotherapy as a primary treatment of OPHG if the
disease
progresses.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Hypothalamic Neoplasms / therapy. Optic Nerve
Glioma
/ therapy. Visual Pathways / pathology
[MeSH-minor]
Adolescent. Child. Child, Preschool.
Disease
Progression. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Predictive Value of Tests. Retrospective Studies. Survival Rate. Treatment Outcome
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(PMID = 18376285.001).
[ISSN]
1077-4114
[Journal-full-title]
Journal of pediatric hematology/oncology
[ISO-abbreviation]
J. Pediatr. Hematol. Oncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
74.
Waha A, GĂŒntner S, Huang TH, Yan PS, Arslan B, Pietsch T, Wiestler OD, Waha A:
Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas.
Neoplasia
; 2005 Mar;7(3):193-9
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[Title]
Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in
astrocytomas
.
In a microarray-based methylation analysis
of astrocytomas
[World Health Organization (WHO) grade II], we identified a CpG island within the first exon of the protocadherin-gamma subfamily A11 (PCDH-gamma-A11) gene that showed hypermethylation compared to normal brain tissue.
Bisulfite sequencing and combined bisulfite restriction analysis (COBRA) was performed to screen low- and high-grade
astrocytomas for
the methylation status of this CpG island.
Hypermethylation was detected in 30 of 34 (88%)
astrocytomas
(WHO grades II and III), 20 of 23 (87%) glioblastomas (WHO grade IV), and 8 of 8 (100%)
glioma
cell lines.
There was a highly significant correlation (P = .00028) between PCDH-gamma-A11 hypermethylation and decreased transcription as determined by competitive reverse transcription polymerase chain reaction in WHO grades II and III
astrocytomas
.
After treatment of
glioma
cell lines with a demethylating agent, transcription of PCDH-gamma-A11 was restored.
In summary, we have identified PCDH-gamma-A11 as a new target silenced epigenetically in
astrocytic
gliomas
.
The inactivation of this cell-cell contact molecule might be involved in the invasive growth
of astrocytoma
cells into normal brain parenchyma.
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[Cites]
Nat Genet. 2000 Feb;24(2):132-8
[
10655057.001
]
[Cites]
J Pathol. 1999 Apr;187(5):530-4
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]
[Cites]
J Neuropathol Exp Neurol. 2000 Jun;59(6):544-58
[
10850867.001
]
(PMID = 15799819.001).
[ISSN]
1522-8002
[Journal-full-title]
Neoplasia (New York, N.Y.)
[ISO-abbreviation]
Neoplasia
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA069065; United States / NCI NIH HHS / CA / R29 CA069065; United States / NCI NIH HHS / CA / CA-69065; United States / NCI NIH HHS / CA / CA-86701
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Cadherins; 0 / PCDH11X protein, human; 0 / Sulfites; 776B62CQ27 / decitabine; M801H13NRU / Azacitidine
[Other-IDs]
NLM/ PMC1501138
75.
Mamedova L, Capra V, Accomazzo MR, Gao ZG, Ferrario S, Fumagalli M, Abbracchio MP, Rovati GE, Jacobson KA:
CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.
Biochem Pharmacol
; 2005 Dec 19;71(1-2):115-25
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In 1321N1
astrocytoma
cells stably expressing human P2Y(1,2,4,6) receptors, CysLT1 antagonists inhibited both the P2Y agonist-induced activation of phospholipase C and intracellular Ca2+ mobilization.
In control
astrocytoma
cells expressing an endogenous M3 muscarinic receptor, 10 microM montelukast had no effect on the carbachol-induced rise in intracellular Ca2+.
COS Scholar Universe.
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.
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.
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CALCIUM, ELEMENTAL
.
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.
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(PMID = 16280122.001).
[ISSN]
0006-2952
[Journal-full-title]
Biochemical pharmacology
[ISO-abbreviation]
Biochem. Pharmacol.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / / Z01 DK031116-21
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Acetates; 0 / Chromones; 0 / DNA Primers; 0 / Membrane Proteins; 0 / Quinolines; 0 / Receptors, Leukotriene; 0 / Receptors, Purinergic P2; 0 / leukotriene D4 receptor; 0 / pranlukast; MHM278SD3E / montelukast; SY7Q814VUP / Calcium; UT0S826Z60 / Uridine Triphosphate
[Other-IDs]
NLM/ NIHMS31385; NLM/ PMC4967539
76.
McNatt SA, Gonzalez-Gomez I, Nelson MD, McComb JG:
Synchronous multicentric pleomorphic xanthoastrocytoma: case report.
Neurosurgery
; 2005 Jul;57(1):E191; discussion E191
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OBJECTIVE AND IMPORTANCE: Pleomorphic xanthoastrocytoma (PXA) is a rare, low-grade
astrocytoma of
adolescence.
INTERVENTION: A right frontal craniotomy was performed for excisional biopsy
of a
superficial lesion beneath the coronal suture.
Three years after treatment, the patient remains neurologically nonfocal and shows no evidence
of disease
progression.
[MeSH-major]
Astrocytoma
. Brain Neoplasms. Neoplasms, Multiple Primary
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(PMID = 15987556.001).
[ISSN]
1524-4040
[Journal-full-title]
Neurosurgery
[ISO-abbreviation]
Neurosurgery
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
77.
Harder T, Plagemann A, Harder A:
Birth weight and subsequent risk of childhood primary brain tumors: a meta-analysis.
Am J Epidemiol
; 2008 Aug 15;168(4):366-73
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Previous studies have suggested that high birth weight is associated with an increased brain
tumor
risk.
The authors identified eight studies involving 1,748,964 children, of whom 4,162 suffered from brain tumors of three histologic types (
astrocytoma
, medulloblastoma, and ependymoma).
For astrocytoma
, high birth weight (>4,000 g) was associated with increased risk (odds ratio = 1.38, 95% confidence interval (CI): 1.07, 1.79), with each 1,000-g increase in birth weight being associated with a 19% (95% CI: 4, 36) increase in risk.
[MeSH-major]
Astrocytoma
/ epidemiology. Birth Weight. Brain Neoplasms / epidemiology. Ependymoma / epidemiology. Fetal Macrosomia / epidemiology. Medulloblastoma / epidemiology
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.
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(PMID = 18579539.001).
[ISSN]
1476-6256
[Journal-full-title]
American journal of epidemiology
[ISO-abbreviation]
Am. J. Epidemiol.
[Language]
eng
[Publication-type]
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
67763-96-6 / Insulin-Like Growth Factor I
78.
Durmaz R, Vural M, IĆildi E, CoĆan E, Ozkara E, Bal C, Ciftçi E, ArslantaĆ A, Atasoy MA:
Efficacy of prognostic factors on survival in patients with low grade glioma.
Turk Neurosurg
; 2008 Oct;18(4):336-44
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[Title]
Efficacy of prognostic factors on survival in patients with low grade
glioma
.
AIM: In this report, we aim to determine the prognostic factors influencing the length of survival in patients with low-grade
gliomas
.
The diagnoses of the patients were histopathologically verified as low-grade
glioma
(LGG).
The medical records of the patients were reviewed for age, gender,
tumor
locations, extent of resection, and presence of seizure, the neurological status as defined by the Karnofsky Performance Scale (KPS) and radiotherapy treatment after surgery as possible prognostic factors.
Median survival time was 216+/-78.52 months
for astrocytoma
Grade I; 115+/-8.22 months
for astrocytoma
Grade II, and 242+/-76.36 months for oligodendroglioma.
Young age, histology
subtype
(oligodendroglioma) and preoperative KPS were determined to have positive influence on survival according to Log Rank Test.
[MeSH-major]
Brain Neoplasms / mortality. Brain Neoplasms / pathology.
Glioma
/ mortality.
Glioma
/ pathology
[MeSH-minor]
Adolescent. Adult. Aged. Aging.
Astrocytoma
/ mortality.
Astrocytoma
/ pathology.
Astrocytoma
/ surgery. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Karnofsky Performance Status. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Oligodendroglioma / mortality. Oligodendroglioma / pathology. Oligodendroglioma / surgery. Prognosis. Reoperation. Retrospective Studies. Seizures / etiology. Survival. Tomography, X-Ray Computed. Young Adult
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.
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(PMID = 19107679.001).
[ISSN]
1019-5149
[Journal-full-title]
Turkish neurosurgery
[ISO-abbreviation]
Turk Neurosurg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Turkey
79.
Stark AM, Fritsch MJ, Claviez A, Dörner L, Mehdorn HM:
Management of tectal glioma in childhood.
Pediatr Neurol
; 2005 Jul;33(1):33-8
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[Title]
Management of tectal
glioma
in childhood.
Tectal
glioma
is a topographical diagnosis including tumors of different histology, mainly low-grade
astrocytomas
.
This report discusses the management of this rare
tumor
in children.
Clinical charts of 12 children with tectal
glioma
treated in our department between 1976 and 2001 were retrospectively reviewed.
The duration between first symptoms and the diagnosis of tectal
glioma
was in the range of 2 days to 9 years.
Ten patients presented with symptoms associated with increased intracranial pressure, one patient presented with ataxia, and in one case tectal
glioma
was an incidental
finding
.
First-line therapy was endoscopic third ventriculostomy in 5 cases (42%), ventriculoperitoneal shunting in 6 cases (50%), and combined partial
tumor
resection and shunting in one case.
Histology was obtained in 5 cases (low-grade
astrocytoma
, n = 4; ependymoma, n = 1).
Tectal
glioma
represents a distinct subgroup of brainstem tumors associated with a good (or favorable) prognosis.
Effective treatment for hydrocephalus is essential; the
tumor
should be monitored by regular clinical examination and magnetic resonance imaging.
Biopsy is warranted in cases with
tumor
progression.
[MeSH-major]
Brain Neoplasms / pathology. Brain Neoplasms / therapy.
Glioma
/ pathology.
Glioma
/ therapy. Superior Colliculi / pathology
[MeSH-minor]
Adolescent. Adult. Child. Child, Preschool.
Disease
Management. Female. Follow-Up Studies. Humans. Infant. Male. Retrospective Studies
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.
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.
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(PMID = 15876519.001).
[ISSN]
0887-8994
[Journal-full-title]
Pediatric neurology
[ISO-abbreviation]
Pediatr. Neurol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
80.
Nakano I, Saigusa K, Kornblum HI:
BMPing off glioma stem cells.
Cancer Cell
; 2008 Jan;13(1):3-4
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[Title]
BMPing off
glioma
stem cells.
Brain
tumor
stem cells (BTSC) bear some similarities to neural stem cells (NSC).
In this issue of Cancer Cell, Lee et al. demonstrate that BMPs have differing effects on different BTSC lines, either promoting or inhibiting an
astrocytic
-like differentiation program.
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[CommentOn]
Cancer Cell. 2008 Jan;13(1):69-80
[
18167341.001
]
(PMID = 18167333.001).
[ISSN]
1535-6108
[Journal-full-title]
Cancer cell
[ISO-abbreviation]
Cancer Cell
[Language]
eng
[Publication-type]
Comment; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Bone Morphogenetic Proteins; 0 / Ciliary Neurotrophic Factor; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I
81.
Shimizu H, Mori O, Ohaki Y, Kamoi S, Kobayashi S, Okada S, Maeda S, Naito Z:
Cytological interface of diffusely infiltrating astrocytoma and its marginal tissue.
Brain Tumor Pathol
; 2005;22(2):59-74
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[Title]
Cytological interface of diffusely infiltrating
astrocytoma
and its marginal tissue.
Cytological differences between infiltrating lesions of the diffusely infiltrating
astrocytoma
(DIA) and reactive gliosis at its periphery have not yet been established.
The cytological findings of this area are important because the surgeon may have to make a rapid diagnosis regarding the existence of the
tumor
.
[MeSH-major]
Astrocytoma
/ pathology. Brain / pathology. Brain Neoplasms / pathology. Glioblastoma / pathology. Gliosis / pathology
[MeSH-minor]
Adult. Astrocytes / ultrastructure. Axons / ultrastructure. Biopsy. Carcinoma / secondary. Cell Nucleus / ultrastructure. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Myelin Sheath / ultrastructure.
Neoplasm
Invasiveness. Neurons / ultrastructure. Oligodendroglia / ultrastructure. Staining and Labeling / methods
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(PMID = 18095107.001).
[ISSN]
1861-387X
[Journal-full-title]
Brain tumor pathology
[ISO-abbreviation]
Brain Tumor Pathol
[Language]
eng
[Publication-type]
Case Reports; Comparative Study; Journal Article
[Publication-country]
Japan
82.
Server A, Kulle B, Maehlen J, Josefsen R, Schellhorn T, Kumar T, Langberg CW, Nakstad PH:
Quantitative apparent diffusion coefficients in the characterization of brain tumors and associated peritumoral edema.
Acta Radiol
; 2009 Jul;50(6):682-9
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BACKGROUND: Conventional magnetic resonance (MR) imaging has a number of limitations in the diagnosis of the most common intracranial brain tumors, including
tumor
specification and the detection of tumoral infiltration in regions of peritumoral edema.
PURPOSE: To prospectively assess if diffusion-weighted MR imaging (DWI) could be used to differentiate between different types of brain tumors and to distinguish between peritumoral infiltration in high-grade
gliomas
, lymphomas, and pure vasogenic edema in metastases and meningiomas.
MATERIAL AND METHODS: MR imaging and DWI was performed on 93 patients with newly diagnosed brain tumors: 59 patients had histologically verified high-grade
gliomas
(37 glioblastomas multiforme, 22 anaplastic
astrocytomas
), 23 patients had metastatic brain tumors, five patients had primary cerebral lymphomas, and six patients had meningiomas.
Apparent diffusion coefficient (ADC) values
of tumor
(enhancing regions or the solid portion
of tumor
) and peritumoral edema, and ADC ratios (ADC
of tumor
or peritumoral edema to ADC of contralateral white matter, ADC
of tumor
to ADC of peritumoral edema) were compared with the histologic diagnosis.
ADC values and ratios of high-grade
gliomas
, primary cerebral lymphomas, metastases, and meningiomas were compared by using ANOVA and multiple comparisons.
Optimal thresholds of ADC values and ADC ratios for distinguishing high-grade
gliomas
from metastases were determined by receiver operating characteristic (ROC) curve analysis.
RESULTS: Statistically significant differences were found for minimum and mean of ADC
tumor
and ADC
tumor
ratio values between metastases and high-grade
gliomas
when including only one factor at a time.
Including a combination of in total four parameters (mean ADC
tumor
, and minimum, maximum and mean ADC
tumor
ratio) resulted in sensitivity, specificity, positive (PPV), and negative predictive values (NPV) of 72.9, 82.6, 91.5, and 54.3% respectively.
CONCLUSION: Our results suggest that ADC values and ADC ratios (minimum and mean of ADC
tumor
and ADC
tumor
ratio) may be helpful in the differentiation of metastases from high-grade
gliomas
.
It cannot distinguish high-grade
gliomas
from lymphomas, and lymphomas from metastases.
ADC values and ADC ratios in peritumoral edema cannot be used to differentiate edema with infiltration
of tumor
cells from vasogenic edema when measurements for high-grade
gliomas
, lymphomas, metastases, and meningiomas were compared.
[MeSH-major]
Brain Edema / pathology. Brain Neoplasms / pathology.
Glioma
/ pathology. Lymphoma / pathology. Meningioma / pathology
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(PMID = 19449234.001).
[ISSN]
1600-0455
[Journal-full-title]
Acta radiologica (Stockholm, Sweden : 1987)
[ISO-abbreviation]
Acta Radiol
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
England
83.
Yang X, Cao W, Lin H, Zhang W, Lin W, Cao L, Zhen H, Huo J, Zhang X:
Isoform-specific expression of 14-3-3 proteins in human astrocytoma.
J Neurol Sci
; 2009 Jan 15;276(1-2):54-9
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[Title]
Isoform-specific expression of 14-3-3 proteins in human
astrocytoma
.
In the present study, the levels of all seven 14-3-3 isoforms were examined in
astrocytoma
.
METHODS: The expression of 14-3-3 isoforms and their protein expression levels were examined in five
glioma
cell lines by western blotting.
Then in
astrocytoma
tissues, we investigated expression percentages of each isoform by immunohistochemistry.
RESULTS: 14-3-3beta and eta were specifically expressed in
astrocytoma
, and their expression frequencies and levels increased with the increase
of astrocytoma
malignancy.
The result from
glioma
cell lines was consistent with that from
astrocytoma
tissue.
CONCLUSIONS: In our study, we found two
tumor
-specific isoforms of 14-3-3 in
astrocytoma
.
They might be involved in
astrocytoma
tumorigenesis and may be useful as targets for therapy.
[MeSH-major]
14-3-3 Proteins / metabolism.
Astrocytoma
/ metabolism
The Lens.
Cited by Patents in
.
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(PMID = 18851859.001).
[ISSN]
0022-510X
[Journal-full-title]
Journal of the neurological sciences
[ISO-abbreviation]
J. Neurol. Sci.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / 14-3-3 Proteins; 0 / Protein Isoforms; 0 / RNA, Messenger
84.
Amin A, Monabati A, Kumar PV, Hashemi SB:
Nasal glioma (neuroglial heterotopia) mimicking an astrocytoma: case report.
Ear Nose Throat J
; 2005 Oct;84(10):657-8
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[Title]
Nasal
glioma
(neuroglial heterotopia) mimicking an
astrocytoma
: case report.
Nasal
glioma
is a rare benign
tumor
that usually occurs during infancy.
We report a case of nasal
glioma
in a 6-month-old boy in which the histomorphologic features resembled those of an anaplastic
astrocytoma
.
[MeSH-major]
Astrocytoma
/ diagnosis.
Glioma
/ diagnosis. Neuroglia / pathology. Nose Neoplasms / diagnosis
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(PMID = 16382748.001).
[ISSN]
0145-5613
[Journal-full-title]
Ear, nose, & throat journal
[ISO-abbreviation]
Ear Nose Throat J
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
85.
Mignot C, Desguerre I, Burglen L, Hertz-Pannier L, Renaldo F, Gadisseux JF, Gallet S, Pham-Dinh D, Boespflug-Tanguy O, Rodriguez D:
Tumor-like enlargement of the optic chiasm in an infant with Alexander disease.
Brain Dev
; 2009 Mar;31(3):244-7
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[Title]
Tumor
-like enlargement of the optic chiasm in an infant with Alexander
disease
.
We report a patient with infantile Alexander
disease
(AXD) due to the recurrent p.Arg79Cys GFAP mutation.
In addition to typical AXD abnormalities, magnetic resonance imaging demonstrated
a tumor
-like lesion of the optic chiasm suggestive
of a
glioma
.
Rare radiological and pathological
tumor
-like lesions have already been reported in AXD patients.
This patient confirms that enlargement of the optic chiasm is a rare feature of AXD, possibly linked to abnormal
astrocytic
proliferation.
[MeSH-major]
Alexander
Disease
/ pathology.
Glioma
/ pathology. Optic Chiasm / pathology. Optic Nerve Neoplasms / pathology
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(PMID = 18584981.001).
[ISSN]
1872-7131
[Journal-full-title]
Brain & development
[ISO-abbreviation]
Brain Dev.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Glial Fibrillary Acidic Protein
86.
Nafe R, Schlote W, Schneider B:
Histomorphometry of tumour cell nuclei in astrocytomas using shape analysis, densitometry and topometric analysis.
Neuropathol Appl Neurobiol
; 2005 Feb;31(1):34-44
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[Title]
Histomorphometry of tumour cell nuclei in
astrocytomas
using shape analysis, densitometry and topometric analysis.
Although tumour cell nuclei are important histological structures for grading
of astrocytomas
according to the WHO-
classification of
brain tumours, there is no reported morphometric study
of astrocytomas
which describes quantitatively the four main
morphologic
criteria of tumour cell nuclei: size, shape, texture (densitometric characteristics) and spatial relationships between the nuclei (topometric analysis).
Using a set of morphometric parameters describing these criteria as well as the Ki67-proliferation index, 74
astrocytomas
from 74 patients were studied by means
of a
digital image analysis system.
The objective of the study was to test, if these morphometric parameters were sufficient for statistical discrimination between pilocytic
astrocytomas
WHO-grade I,
astrocytomas
grade II and anaplastic
astrocytomas
grade III.
In conclusion, the present morphometric procedure provided good discrimination between the tumour grades, supporting the view that histomorphometry of tumour cell nuclei could be a valuable tool for grading
of astrocytomas
.
[MeSH-major]
Astrocytoma
/ pathology.
Astrocytoma
/ ultrastructure. Brain Neoplasms / pathology. Brain Neoplasms / ultrastructure. Cell Nucleus / pathology. Cell Nucleus / ultrastructure
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(PMID = 15634229.001).
[ISSN]
0305-1846
[Journal-full-title]
Neuropathology and applied neurobiology
[ISO-abbreviation]
Neuropathol. Appl. Neurobiol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
87.
Xiong J, Liu Y, Wang Y, Ke RH, Mao Y, Ye ZR:
Chromosome 1p/19q status combined with expression of p53 protein improves the diagnostic and prognostic evaluation of oligodendrogliomas.
Chin Med J (Engl)
; 2010 Dec;123(24):3566-73
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In order to improve the diagnostic criteria and to predict the prognosis of oligodendroglioma patients, the status of chromosome 1p/19q deletion, the methylation
of O
(6)-methylguanine-DNA methyltransferase (MGMT), and the expression of p53 protein were evaluated and investigated in relation to patients' outcomes.
RESULTS: Both oligodendrogliomas and
astrocytic
gliomas
exhibited frequent methylation of MGMT.
[MeSH-major]
Brain Neoplasms / genetics. Chromosome Deletion. Chromosomes, Human, Pair 19. Oligodendroglioma / genetics.
Tumor
Suppressor Protein p53 / analysis
[MeSH-minor]
Adolescent. Adult. Aged.
Astrocytoma
/ genetics. Child. Chromosomes, Human, Pair 1. DNA Methylation. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics.
Disease
-Free Survival. Female. Gene Expression Regulation, Neoplastic. Humans. Loss of Heterozygosity. Male. Middle Aged. Prognosis.
Tumor
Suppressor Proteins / genetics
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.
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(PMID = 22166632.001).
[ISSN]
0366-6999
[Journal-full-title]
Chinese medical journal
[ISO-abbreviation]
Chin. Med. J.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
China
[Chemical-registry-number]
0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes; Chromosome 1, monosomy 1p
88.
Endale M, Kim SD, Lee WM, Kim S, Suk K, Cho JY, Park HJ, Wagley Y, Kim S, Oh JW, Rhee MH:
Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes.
Am J Physiol Cell Physiol
; 2010 Mar;298(3):C611-23
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We report the role of ischemic stress in RGS2 protein expression in rat C6
astrocytoma
cells and primary mouse astrocytes.
[MeSH-minor]
Animals. Caspase 3 / metabolism. Cell Hypoxia. Cell Line,
Tumor
. Glucose / deficiency. Humans. Mice. Oxidative Stress. Phosphorylation. Protein Kinase C-delta / antagonists & inhibitors. Protein Kinase C-delta / genetics. Protein Kinase C-delta / metabolism. Protein Kinase Inhibitors / pharmacology. RNA Interference. RNA, Messenger / metabolism. Rats. Recombinant Fusion Proteins / metabolism. Signal Transduction. Time Factors. Transfection. Up-Regulation. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors. p38 Mitogen-Activated Protein Kinases / metabolism
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.
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(PMID = 20032508.001).
[ISSN]
1522-1563
[Journal-full-title]
American journal of physiology. Cell physiology
[ISO-abbreviation]
Am. J. Physiol., Cell Physiol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Protein Kinase Inhibitors; 0 / RGS Proteins; 0 / RGS2 protein, human; 0 / RGS2 protein, rat; 0 / RNA, Messenger; 0 / Recombinant Fusion Proteins; 0 / Rgs2 protein, mouse; EC 2.7.11.13 / Protein Kinase C-delta; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.4.22.- / Caspase 3; IY9XDZ35W2 / Glucose
89.
Narayana A, Bhatia S, Souweidane M, Khakoo Y, Zaider M:
(32)P radioisotope therapy for recurrent pilocytic astrocytoma.
Brachytherapy
; 2005;4(2):171-3
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[Title]
(32)P radioisotope therapy for recurrent pilocytic
astrocytoma
.
Its effectiveness in the treatment
of a
selected brain
tumor
is illustrated here.
[MeSH-major]
Astrocytoma
/ radiotherapy. Basal Ganglia / pathology. Brachytherapy / methods. Brain Neoplasms / radiotherapy.
Neoplasm
Recurrence, Local / radiotherapy. Phosphorus Radioisotopes / therapeutic use
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.
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(PMID = 15893272.001).
[ISSN]
1538-4721
[Journal-full-title]
Brachytherapy
[ISO-abbreviation]
Brachytherapy
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Colloids; 0 / Phosphorus Radioisotopes
90.
Holland H, Koschny T, Ahnert P, Meixensberger J, Koschny R:
WHO grade-specific comparative genomic hybridization pattern of astrocytoma - a meta-analysis.
Pathol Res Pract
; 2010 Oct 15;206(10):663-8
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[Title]
WHO grade-specific comparative genomic hybridization pattern
of astrocytoma
- a meta-analysis.
To detect novel genetic alterations, many
astrocytomas
have been investigated by comparative genomic hybridization (CGH).
To identify aberration profiles characteristic of World Health Organization (WHO) grade I, II, III, and IV
astrocytoma
, we performed a meta-analysis of detailed genome wide CGH data of all 467 cases published so far.
Low-grade
astrocytoma
has already demonstrated one characteristic of glioblastoma multiforme, gain of chromosome 7 with a hot spot at 7q32, but without loss of chromosome 10.
In anaplastic
astrocytoma
, a more complex aberration pattern emerges from diffuse genetic imbalances.
In contrast to lower
tumor
grades, glioblastoma multiforme demonstrates +7p12 as the most frequently affected band on chromosome 7.
To quantify the gradual transition from WHO grade II-IV
astrocytoma
, we calculated the relative increase and decrease in frequency for each detected aberration of the
tumor
genome.
The most pronounced and diverse changes of genetic material occur at the virtual transition from low-grade to anaplastic
astrocytoma
.
Summing up, the expansion of the CGH results to the 850 GTG-band resolution enabled a meta-analysis to visualize WHO grade-specific aberration profiles in
astrocytoma
.
[MeSH-major]
Astrocytoma
/ genetics. Brain Neoplasms / genetics. Chromosome Aberrations. Comparative Genomic Hybridization. Glioblastoma / genetics. World Health Organization
[MeSH-minor]
Gene Expression Regulation, Neoplastic. Genotype. Humans.
Neoplasm
Staging. Phenotype. Prognosis
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[Copyright]
Copyright © 2010 Elsevier GmbH. All rights reserved.
(PMID = 20570053.001).
[ISSN]
1618-0631
[Journal-full-title]
Pathology, research and practice
[ISO-abbreviation]
Pathol. Res. Pract.
[Language]
eng
[Publication-type]
Journal Article; Meta-Analysis
[Publication-country]
Germany
91.
van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, Malmström PO, Collette L, Piérart M, Mirimanoff R, Karim AB, EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council:
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial.
Lancet
; 2005 Sep 17-23;366(9490):985-90
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[Title]
Long-term efficacy of early versus delayed radiotherapy for low-grade
astrocytoma
and oligodendroglioma in adults: the EORTC 22845 randomised trial.
BACKGROUND: Postoperative policies of "wait-and-see" and radiotherapy for low-grade
glioma
are poorly defined.
In 1986 the EORTC Radiotherapy and Brain
Tumor
Groups initiated a prospective trial to compare early radiotherapy with delayed radiotherapy.
Patients with low-grade
astrocytoma
, oligodendroglioma, mixed oligoastrocytoma, and incompletely resected pilocytic
astrocytoma
, with a WHO performance status 0-2 were eligible.
Radiotherapy could be deferred for patients with low-grade
glioma
who are in a good condition, provided they are carefully monitored.
[MeSH-major]
Astrocytoma
/ radiotherapy. Central Nervous System Neoplasms / radiotherapy. Oligodendroglioma / radiotherapy
[MeSH-minor]
Adolescent. Adult. Aged.
Disease
Progression.
Disease
-Free Survival. Female. Humans. Male. Middle Aged. Radiotherapy Dosage. Survival Rate
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[CommentIn]
Lancet Oncol. 2005 Dec;6(12):921; author reply 922
[
16321759.001
]
[ErratumIn]
Lancet. 2006 Jun 3;367(9525):1818
(PMID = 16168780.001).
[ISSN]
1474-547X
[Journal-full-title]
Lancet (London, England)
[ISO-abbreviation]
Lancet
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / 5U10 CA11488-; United States / NCI NIH HHS / CA / 5U10 CA11488-16
[Publication-type]
Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
England
92.
Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD:
Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival.
Cancer Res
; 2006 Apr 15;66(8):4531-41
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[Title]
Serum IgE,
tumor
epidermal growth factor receptor expression, and inherited polymorphisms associated with
glioma
survival.
In population-based
glioma
patients, we examined survival in relation to potentially pertinent constitutive polymorphisms, serologic factors, and
tumor
genetic and protein alterations in epidermal growth factor receptor (EGFR), MDM2, and TP53.
We obtained 595 of 697
astrocytic
tumors for marker studies.
Using a stringent P < 0.001,
glioma
survival was associated with ERCC1 C8092A [hazard ratio (HR), 0.72; 95% confidence limits (95% CL), 0.60-0.86; P = 0.0004] and GSTT1 deletion (HR, 1.64; 95% CL, 1.25-2.16; P = 0.0004); glioblastoma patients with elevated IgE had 9 months longer survival than those with normal or borderline IgE levels (HR, 0.62; 95% CL, 0.47-0.82; P = 0.0007), and EGFR expression in anaplastic
astrocytoma
was associated with nearly 3-fold poorer survival (HR, 2.97; 95% CL, 1.70-5.19; P = 0.0001).
We also suggest that
tumor
EGFR expression be incorporated into clinical evaluation of anaplastic
astrocytoma
patients.
[MeSH-major]
Astrocytoma
/ genetics. Glioblastoma / genetics. Immunoglobulin E / blood. Receptor, Epidermal Growth Factor / biosynthesis
[MeSH-minor]
Biomarkers,
Tumor
/ biosynthesis. Biomarkers,
Tumor
/ genetics. Humans. Middle Aged. Polymorphism, Genetic
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(PMID = 16618782.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA097257; United States / NCI NIH HHS / CA / CA52689; United States / NCI NIH HHS / CA / CA89032; United States / NIEHS NIH HHS / ES / ES04705; United States / NIEHS NIH HHS / ES / ES06717
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 37341-29-0 / Immunoglobulin E; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
93.
Li B, Qi XQ, Chen X, Huang X, Liu GY, Chen HR, Huang CG, Luo C, Lu YC:
Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma.
Brain Res
; 2010 Sep 17;1352:200-7
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[Title]
Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant
astrocytoma
.
However, the contribution of TPX2 expression to
astrocytoma
progression is unclear.
The aim of this study was to investigate TPX2 expression in human
astrocytoma
samples and cell lines.
TPX2 protein expression was detected in the nucleus
of astrocytoma
tissues by immunohistochemistry and immunofluorescence staining.
Real-time PCR and Western blot analysis showed that the expression levels of TPX2 were higher in high-grade
astrocytoma
tissues and cell lines than that in low-grade
astrocytoma
tissues and normal cell lines.
Immunohistochemical analysis
of tumor
tissues from 52 patients with
astrocytoma
showed that TPX2 over-expression was significantly associated with decreased patient survival.
These data suggest that TPX2 expression is associated with the progression of malignant
astrocytoma
.
[MeSH-major]
Astrocytoma
/ genetics. Brain Neoplasms / genetics. Cell Cycle Proteins / genetics. Microtubule-Associated Proteins / genetics. Nuclear Proteins / genetics
[MeSH-minor]
Apoptosis. Aurora Kinases. Brain / metabolism. Cell Division. Cell Line,
Tumor
. Cyclin B1 / genetics. Cyclin D1 / genetics.
Disease
Progression. Down-Regulation. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Protein-Serine-Threonine Kinases / genetics. Proto-Oncogene Proteins c-myc / genetics. Survival Rate.
Tumor
Suppressor Protein p53 / genetics
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Cited by Patents in
.
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(PMID = 20599806.001).
[ISSN]
1872-6240
[Journal-full-title]
Brain research
[ISO-abbreviation]
Brain Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Cell Cycle Proteins; 0 / Cyclin B1; 0 / Microtubule-Associated Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins c-myc; 0 / TPX2 protein, human; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
94.
Ohta K, Kuwahara K, Zhang Z, Makino K, Komohara Y, Nakamura H, Kuratsu J, Sakaguchi N:
Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas.
Cancer Sci
; 2009 Nov;100(11):2069-76
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[Title]
Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant
gliomas
.
Malignant
glioma
(MG) is highly proliferative and invasive, with the malignant characteristics associated with aneuploidy and chromosomal instability (CIN).
Glioblastomas showed a significantly lower level of ganp mRNA than anaplastic
astrocytomas
, as measured by real-time reverse transcription-PCR, in 101 cases of adult MG.
[MeSH-major]
Acetyltransferases / physiology. Brain Neoplasms / genetics. Chromosomal Instability.
Glioma
/ genetics
[MeSH-minor]
Adolescent. Adult. Aged. Cell Cycle. Cell Line,
Tumor
. Cell Proliferation. Female. Genes, p53. Humans. Intracellular Signaling Peptides and Proteins. Loss of Heterozygosity. Male. Middle Aged. Mutation. RNA Interference. Receptor, Epidermal Growth Factor / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
Saccharomyces Genome Database.
Saccharomyces Genome Database
.
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(PMID = 19686285.001).
[ISSN]
1349-7006
[Journal-full-title]
Cancer science
[ISO-abbreviation]
Cancer Sci.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Intracellular Signaling Peptides and Proteins; EC 2.3.1.- / Acetyltransferases; EC 2.3.1.- / MCM3AP protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
95.
Montemor JP, Peria FM, Monti CR, Petrilli LS, Colli BO, Carlotti JĂșnior CG:
Concurrent chemoradiotherapy with weekly paclitaxel in malignant cerebral glioma treatment.
Onkologie
; 2008 Sep;31(8-9):435-9
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[Title]
Concurrent chemoradiotherapy with weekly paclitaxel in malignant cerebral
glioma
treatment.
BACKGROUND: Anaplastic
astrocytomas
(AA) and glioblastomas (GB) are the most common malignant
gliomas
, and despite newly developed drugs and combined treatments, they still have an adverse prognosis.
Paclitaxel is a cytotoxic agent with radiosensitizing properties and exerts objective growth inhibition in
glioma
tumor
cells.
CONCLUSIONS: Chemoradiotherapy with weekly paclitaxel is safe and tolerable although there was no increase in the overall survival and 12-month survival of malignant
glioma
patients.
[MeSH-major]
Brain Neoplasms / drug therapy. Brain Neoplasms / radiotherapy.
Glioma
/ drug therapy.
Glioma
/ radiotherapy. Paclitaxel / administration & dosage
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
Hazardous Substances Data Bank.
TAXOL
.
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[Copyright]
Copyright 2008 S. Karger AG, Basel.
(PMID = 18787350.001).
[ISSN]
1423-0240
[Journal-full-title]
Onkologie
[ISO-abbreviation]
Onkologie
[Language]
eng
[Publication-type]
Journal Article; Randomized Controlled Trial
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Antineoplastic Agents; P88XT4IS4D / Paclitaxel
96.
Ikota H, Kinjo S, Yokoo H, Nakazato Y:
Systematic immunohistochemical profiling of 378 brain tumors with 37 antibodies using tissue microarray technology.
Acta Neuropathol
; 2006 May;111(5):475-82
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Our TMA consisted
of a
grid of 1.5-mm cores that were extracted from individual donor blocks.
Ten antibodies [glial fibrillary acidic protein (GFAP), Olig2, vimentin, epithelial membrane antigen (EMA), cytokeratin (AE1/AE3), alpha-internexin, nestin, pinealocytes PP5, aquaporin-4 (AQP4) M13d and AQP4M13e] discriminated between
astrocytomas
and oligodendroglial tumors.
Six antibodies [EMA, AE1/AE3, TUJ1, nestin, neurofilament protein-MH (NF-MH) and perivascular cells GP-1] showed significant differences between high-grade and low-grade
gliomas
.
Our data have revealed new antibodies with potential diagnostic utility (Olig2, PP5, GP-1) and demonstrate that TMA technology is highly useful for evaluating newly established antibodies in brain-
tumor
research.
[MeSH-major]
Antibodies / immunology.
Astrocytoma
/ immunology. Brain Neoplasms / immunology. Immunohistochemistry / methods. Oligodendroglioma / immunology. Protein Array Analysis / methods
[MeSH-minor]
Aquaporin 4 / immunology. Aquaporin 4 / metabolism. Basic Helix-Loop-Helix Transcription Factors / immunology. Basic Helix-Loop-Helix Transcription Factors / metabolism. Biomarkers,
Tumor
/ immunology. Biomarkers,
Tumor
/ metabolism. Cluster Analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / immunology. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / immunology. Intermediate Filament Proteins / metabolism. Mucin-1 / immunology. Mucin-1 / metabolism. Nerve Tissue Proteins / immunology. Nerve Tissue Proteins / metabolism. Nestin. Prognosis. Vimentin / immunology. Vimentin / metabolism
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consumer health - Brain Tumors
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 16598485.001).
[ISSN]
0001-6322
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / AQP4 protein, human; 0 / Antibodies; 0 / Aquaporin 4; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Mucin-1; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / OLIG2 protein, human; 0 / Vimentin; 0 / alpha-internexin
97.
Kitis O, Altay H, Calli C, Yunten N, Akalin T, Yurtseven T:
Minimum apparent diffusion coefficients in the evaluation of brain tumors.
Eur J Radiol
; 2005 Sep;55(3):393-400
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OBJECTIVE: To determine whether diffusion-weighted imaging by using minimum apparent diffusion coefficient (ADC(min)) values could differentiate various brain tumors including
gliomas
, metastases, and lymphomas.
MATERIALS AND METHODS: We examined 65 patients with histologically or clinically diagnosed brain tumors (12 low-grade
gliomas
, 31 high-grade
gliomas
, 14 metastatic tumors, and 8 lymphomas) using a 1.5 T MR unit.
RESULTS: The ADC(min) values of low-grade
gliomas
(1.09+/-0.20 x 10(-3)mm(2)/s) were significantly higher (p<.001) than those of other tumors.
There were no statistical significant differences between glioblastomas (0.70+/-0.16 mm(2)/s), anaplastic
astrocytomas
(0.77+/-0.21 mm(2)/s), metastases (0.78+/-0.21 mm(2)/s), and lymphomas.
But, lymphomas had lower mean ADC(min) values (0.54+/-0.10mm(2)/s) than high-grade
gliomas
and metastases.
CONCLUSION: The ADC measurements may help to differentiate low-grade
gliomas
from high-grade
gliomas
, metastases, and lymphomas.
[MeSH-minor]
Adult. Aged. Analysis of Variance. Diagnosis, Differential. Female.
Glioma
/ pathology. Humans. Lymphoma / pathology. Male. Middle Aged.
Neoplasm
Metastasis / pathology
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.
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(PMID = 16129247.001).
[ISSN]
0720-048X
[Journal-full-title]
European journal of radiology
[ISO-abbreviation]
Eur J Radiol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Ireland
98.
Morales H, Kwock L, Castillo M:
Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas.
J Comput Assist Tomogr
; 2007 Sep-Oct;31(5):682-7
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[Title]
Magnetic resonance imaging and spectroscopy of pilomyxoid
astrocytomas
: case reports and comparison with pilocytic
astrocytomas
.
BACKGROUND AND PURPOSE: Pilomyxoid
astrocytomas
(PMAs) have been described only recently.
They appear as low-grade tumors sharing imaging features similar to pilocytic
astrocytomas
(PAs).
However, pilomyxoid
astrocytomas
have different histological features and behave more aggressively than PAs.
[MeSH-major]
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Magnetic Resonance Imaging / methods. Magnetic Resonance Spectroscopy / methods. Myxoma / metabolism. Myxoma / pathology
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - MRI Scans
.
Hazardous Substances Data Bank.
CREATINE
.
Hazardous Substances Data Bank.
CHOLINE CHLORIDE
.
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(PMID = 17895777.001).
[ISSN]
0363-8715
[Journal-full-title]
Journal of computer assisted tomography
[ISO-abbreviation]
J Comput Assist Tomogr
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
4L6452S749 / Inositol; MU72812GK0 / Creatine; N91BDP6H0X / Choline
99.
Fakhrai H, Mantil JC, Liu L, Nicholson GL, Murphy-Satter CS, Ruppert J, Shawler DL:
Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma.
Cancer Gene Ther
; 2006 Dec;13(12):1052-60
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[Title]
Phase I clinical trial
of a
TGF-beta antisense-modified
tumor
cell vaccine in patients with advanced
glioma
.
We performed a phase I clinical trial in grade IV
astrocytoma
to assess the safety
of a
whole-cell vaccine comprising autologous
tumor
cells genetically modified by a transforming growth factor-beta2 (TGF-beta2) antisense vector.
Blocking secretion of the immunosuppressive molecule TGF-beta in this manner should inhibit one of the major mechanisms by which
tumor
cells evade immune surveillance and should lead to clinically effective antitumor immunity.
Six patients with progressive WHO grade IV
astrocytoma
were enrolled in the trial.
Patients received 2-7 subcutaneous injections of 5 x 10(6)-2 x 10(7) autologous
tumor
cells per injection.
TGF-beta2 secretion by the
tumor
cells used to vaccinate patients was inhibited by 53-98%.
Two patients had partial regressions and two had stable
disease
following therapy.
Median survival of the responding patients was 78 weeks, compared to a historic value of 47 weeks for
glioma
patients treated conventionally.
These findings support further clinical evaluation of vaccines comprised of TGF-beta antisense-modified
tumor
cells.
[MeSH-major]
Cancer Vaccines / therapeutic use. Central Nervous System Neoplasms / drug therapy.
Glioma
/ drug therapy. Oligonucleotides, Antisense / genetics. Transforming Growth Factor beta2 / genetics
[MeSH-minor]
Adult. Antibody Formation. Female. Humans. Injections, Intradermal. Male. Middle Aged. Treatment Outcome.
Tumor
Cells, Cultured
Genetic Alliance.
consumer health - Glioma
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
The Lens.
Cited by Patents in
.
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(PMID = 16826191.001).
[ISSN]
0929-1903
[Journal-full-title]
Cancer gene therapy
[ISO-abbreviation]
Cancer Gene Ther.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA105964; United States / NCI NIH HHS / CA / CA96025
[Publication-type]
Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
England
[Chemical-registry-number]
0 / Cancer Vaccines; 0 / Oligonucleotides, Antisense; 0 / Transforming Growth Factor beta2
100.
Opstad KS, Bell BA, Griffiths JR, Howe FA:
Taurine: a potential marker of apoptosis in gliomas.
Br J Cancer
; 2009 Mar 10;100(5):789-94
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[Title]
Taurine: a potential marker of apoptosis in
gliomas
.
Magnetic resonance spectroscopy (MRS) can determine the tumour biochemical profile in vivo, and we have investigated whether a specific spectroscopic signature exists for apoptosis in human
astrocytomas
.
Metabolites, mobile lipids and macromolecules were quantified from presaturation HRMAS (1)H spectra acquired from 41 biopsies of grades II (n=8), III (n=3) and IV (n=30)
astrocytomas
.
We suggest that the taurine (1)H MRS signal in
astrocytomas
may be a robust apoptotic biomarker that is independent of tumour necrotic status.
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