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1. Meulenbeld HJ, van Steenbergen LN, Janssen-Heijnen ML, Lemmens VE, Creemers GJ: Significant improvement in survival of patients presenting with metastatic colon cancer in the south of The Netherlands from 1990 to 2004. Ann Oncol; 2008 Sep;19(9):1600-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significant improvement in survival of patients presenting with metastatic colon cancer in the south of The Netherlands from 1990 to 2004.
  • BACKGROUND: In randomised controlled trials, the median overall survival (OS) for patients with metastatic colon cancer has improved.
  • We retrospectively analysed population-based survival data of patients who presented with metastatic colon cancer at diagnosis.
  • PATIENTS AND METHODS: All patients diagnosed with primary metastatic colon cancer from 1990 to 2004 in the registration area of the Eindhoven Cancer Registry were included.
  • Date of diagnosis was divided into four periods (1990-1994, 1995-1999, 2000-2002, and 2003-2004) according to the availability of chemotherapy for metastatic colon cancer.
  • CONCLUSION: Palliative chemotherapy significantly improved OS in unselected patients with metastatic colon cancer.

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  • (PMID = 18467312.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Gmeiner WH, Hellmann GM, Shen P: Tissue-dependent and -independent gene expression changes in metastatic colon cancer. Oncol Rep; 2008 Jan;19(1):245-51
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  • [Title] Tissue-dependent and -independent gene expression changes in metastatic colon cancer.
  • The goal of this study was to identify systematic alterations in key cell signaling and metabolic pathways that occur during colon cancer carcinogenesis and metastasis.
  • Gene expression levels for primary colon samples were compared to a normal colon while metastatic tissues were compared to the primary colon.
  • Primary colon samples displayed high positive z-scores (indicating a gene ontology term that occurs more frequently than expected) for genes involved in Wnt-signaling (4.11), nitrogen metabolism (7.30) and inositol phosphate metabolism (2.47).
  • Metastatic tissue from the liver and omentum, but not the lung, displayed a decreased expression of genes important for oxidative phosphorylation.
  • The metastatic tissue from all sites displayed a substantially decreased expression for genes involved in butanoate and propanoate metabolism and valine, leucine and isoleucine degradation.
  • These expression level changes complement the spectrum of mutations that characterize the progression of colorectal cancer.

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  • (PMID = 18097602.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA102532; United States / NCI NIH HHS / CA / P30 CA12197
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Wnt Proteins; 9007-36-7 / Complement System Proteins
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3. Hoogerwerf WA: Biologic clocks and the gut. Curr Gastroenterol Rep; 2006 Oct;8(5):353-9
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  • Furthermore, the development of gastrointestinal complications after administration of aspirin and after chemo- and radiotherapy for metastatic colon cancer depends on the time of administration.

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  • (PMID = 16968601.001).
  • [ISSN] 1522-8037
  • [Journal-full-title] Current gastroenterology reports
  • [ISO-abbreviation] Curr Gastroenterol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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4. Grasso G, Meli F, Patti R, Giambartino F, Florena AM, Iacopino DG: Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature. Spinal Cord; 2007 Dec;45(12):793-6
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  • [Title] Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature.
  • OBJECTIVE: Intramedullary spinal cord metastases (ISCMs) are rare type of central nervous system (CNS) involvement of systemic malignant tumors.
  • Magnetic resonance imaging of the brain did not reveal other CNS metastatic lesions.
  • Histological examination of the lesion showed the typical features of a colon carcinoma metastasis.

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  • (PMID = 17637763.001).
  • [ISSN] 1362-4393
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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5. Chen J, Huang XF: The signal pathways in azoxymethane-induced colon cancer and preventive implications. Cancer Biol Ther; 2009 Jul;8(14):1313-7
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  • [Title] The signal pathways in azoxymethane-induced colon cancer and preventive implications.
  • Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics.
  • The carcinogenesis of colon cancer has been associated with both genetics and environmental factors.
  • The 5 y survival rate of metastatic colon cancer is below 10%.
  • Azoxymethane (AOM) is a common model for colon cancer.
  • It can specifically induce colon cancer similar to the pathogenesis of human sporadic colon cancer.
  • Thus, it has been extensively used in the study of the molecular biology, prevention and treatment of colon cancer.
  • Mutation of K-ras activates this pathway and its downstream PI3K/Akt pathway and MAPK pathway.
  • This model has been used in the study of the genetic deficiencies of colon cancer and in the prevention and treatment of the disease.

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  • (PMID = 19502780.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Anticarcinogenic Agents; 0 / Carcinogens; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta2; 590-96-5 / methylazoxymethanol; 592-62-1 / Methylazoxymethanol Acetate; EC 1.14.13.- / Cytochrome P-450 CYP2E1; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; MO0N1J0SEN / Azoxymethane
  • [Number-of-references] 58
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6. LaBarge MA, Bissell MJ: Is CD133 a marker of metastatic colon cancer stem cells? J Clin Invest; 2008 Jun;118(6):2021-4
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  • [Title] Is CD133 a marker of metastatic colon cancer stem cells?
  • The concept of the so-called cancer stem cell (CSC) holds that only a minority of cells within a tumor have the ability to generate a new tumor.
  • In this issue of the JCI, Shmelkov et al. challenge the view that CD133 is a marker of CSCs in colon cancer (see the related article beginning on page 2111).
  • CD133 was thought previously to have a very restricted distribution within tissues; the authors have used genetic knock-in models to demonstrate that CD133 in fact is expressed on a wide range of differentiated epithelial cells in adult mouse tissues and on spontaneous primary colon tumors in mice.
  • In primary human colon tumors, all of the epithelial cells also expressed CD133, whereas metastatic colon cancers isolated from liver had distinct CD133+ and CD133- epithelial populations.
  • In light of these new findings, the popular notion that CD133 is a marker of colon CSCs may need to be revised.

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  • (PMID = 18497883.001).
  • [ISSN] 0021-9738
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA064786; United States / NCI NIH HHS / CA / U54 CA126552; United States / NCI NIH HHS / CA / R01CA064786; United States / NCI NIH HHS / CA / U54CA126552
  • [Publication-type] Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Peptides
  • [Other-IDs] NLM/ PMC2391070
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7. Cienki JJ, Zaret L: An Internet misadventure: bloodroot salve toxicity. J Altern Complement Med; 2010 Oct;16(10):1125-7
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  • Pathological examination of the lesion revealed malignant melanoma.
  • CASE REPORT 2: A 42-year-old man with a history of metastatic colon cancer developed palpable subcutaneous nodules on the anterior abdominal wall.
  • The patient's mother searched the Internet for cancer salves and purchased black and yellow bloodroot salve.
  • Web sites discuss the efficacy of bloodroot in treating skin cancer.

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  • (PMID = 20932193.001).
  • [ISSN] 1557-7708
  • [Journal-full-title] Journal of alternative and complementary medicine (New York, N.Y.)
  • [ISO-abbreviation] J Altern Complement Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts
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8. Pasetto LM, Falci C, Rizzo E, De Salvo GL, Gasparini G, D'Andrea M, Bajetta E, Platania M, Alabiso O, Miraglia S, Oniga F, Biason R, Chetrì MC, Fedele P, Massara G, Romaniello I, Giordano M, Luchena G, Buzzi F, Ricotta R, Siena S, Monfardini S: Palliative treatment for elderly patients with colon cancer in ten Italian medical oncology units. Anticancer Res; 2008 May-Jun;28(3B):1813-20
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  • [Title] Palliative treatment for elderly patients with colon cancer in ten Italian medical oncology units.
  • BACKGROUND: Palliative chemotherapy significantly reduces mortality in patients with stage IV colon cancer, but is less prescribed with rising age.
  • PATIENTS AND METHODS: From January to December 2004, 78 files on the management of stage IV colorectal cancer (CRC) patients over 70 years, collected from 10 Italian Centres, were retrospectively examined.
  • CONCLUSION: In Italy, a proportion of elderly patients with metastatic chemonaive CRC are usually treated with a tolerability and overall survival similar to those for the younger population.
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Capecitabine. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Disease Progression. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Fluorouracil / analogs & derivatives. Fluorouracil / therapeutic use. Humans. Italy. Leucovorin / administration & dosage. Male. Medical Oncology / methods. Mitomycin / administration & dosage. Neoplasm Staging. Oncology Service, Hospital. Organoplatinum Compounds / administration & dosage. Retrospective Studies. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 18630465.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 1548R74NSZ / Tegafur; 50SG953SK6 / Mitomycin; 56HH86ZVCT / Uracil; 6804DJ8Z9U / Capecitabine; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; 1-UFT protocol
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9. Ryan DP: Nonsurgical approaches to colorectal cancer. Oncologist; 2006 Oct;11(9):999-1002
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  • [Title] Nonsurgical approaches to colorectal cancer.
  • It is time to challenge the current orthodoxy that frowns upon surgical and nonsurgical methods of tumor reduction for patients with metastatic colon cancer.
  • Although the studies conducted with radiofrequency ablation, chemoembolization, and radiation therapy in patients with metastatic colon cancer have tended to be small and may have been subject to selection bias, they have produced survival data that require careful consideration.

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  • (PMID = 17030641.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 039LU44I5M / Floxuridine
  • [Number-of-references] 16
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10. Kurkjian C, Murgo AJ, Kummar S: Treatment of recurrent metastatic colon cancer in the age of modern adjuvant therapy. Clin Colorectal Cancer; 2008 Sep;7(5):321-4
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  • [Title] Treatment of recurrent metastatic colon cancer in the age of modern adjuvant therapy.
  • The treatment of patients with metastatic colon cancer has evolved tremendously over the past 10 years, with improved overall survival (OS) rates as a result of the advent of several important agents.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Colonic Neoplasms / pathology. Colonic Neoplasms / therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / therapy

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  • (PMID = 18794064.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 31
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11. Huerta S, Li HC: Bowel perforation from bevacizumab for the management of colorectal cancer. Anticancer Drugs; 2009 May;20 Spec No 2:S19-21
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  • [Title] Bowel perforation from bevacizumab for the management of colorectal cancer.
  • Bevacizumab (Avastin) is a recently developed monoclonal antibody, which targets the vascular endothelial growth factor receptor pathway, and is currently used in combination with cytotoxic agents as first-line or second-line therapy for patients with metastatic colon cancer.
  • In this report, we discuss a patient with bowel perforation from bevacizumab for the treatment of metastatic colorectal cancer.

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  • (PMID = 19352105.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Fumagalli D, Gavin PG, Taniyama Y, Kim SI, Choi HJ, Paik S, Pogue-Geile KL: A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes. BMC Cancer; 2010 Mar 16;10:101
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  • [Title] A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes.
  • Our goal was to develop a high throughput, cost-effective and simple methodology for the detection of clinically relevant hot spot mutations in colon cancer.
  • METHODS: The Maldi-Tof mass spectrometry platform and OncoCarta panel from Sequenom were used to profile 239 colon cancers and 39 metastatic lymph nodes from NSABP clinical trial C-07 utilizing routinely processed FFPET (formalin-fixed paraffin-embedded tissue).
  • RESULTS: Among the 238 common hot-spot cancer mutations in 19 genes interrogated by the OncoCarta panel, mutations were detected in 7 different genes at 26 different nucleotide positions in our colon cancer samples.
  • Further evidence demonstrating the validity of the data was the fact that the mutation frequencies of the most common colon cancer mutations were similar to the COSMIC (Catalog of Somatic Mutations in Cancer) database.
  • Mutation profiling of metastatic lymph nodes and their corresponding primary tumors showed that they were 89.7% concordant.
  • CONCLUSIONS: This study describes a high throughput technology that can be used to interrogate DNAs isolated from routinely processed FFPET and identifies the specific mutations that are common to colon cancer.


13. Renouf D, Kennecke H, Gill S: Trends in chemotherapy utilization for colorectal cancer. Clin Colorectal Cancer; 2008 Nov;7(6):386-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in chemotherapy utilization for colorectal cancer.
  • BACKGROUND: Since 1990, significant advances have occurred in the adjuvant and metastatic treatment of colorectal cancer (CRC).
  • In this study, treatment patterns of patients referred to the British Columbia Cancer Agency (BCCA) with early-stage colon cancer and metastatic CRC between 1990 and 2004 are described.
  • PATIENTS AND METHODS: This study included patients with stage II or III colon cancer or stage IV CRC at presentation referred to the BCCA during a 1-year period for 3 time cohorts: 1990, 2000, and 2004.
  • RESULTS: A total of 1421 patients were included: stage II/III, n = 915; stage IV, n = 506.
  • The proportion of patients with stage II disease treated with adjuvant CT dramatically increased (1990: 4%; 2000: 26%; 2004: 30%; P < .001).
  • [MeSH-minor] Aged. British Columbia / epidemiology. Chemotherapy, Adjuvant. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Palliative Care. Retrospective Studies. Risk Factors. Survival Analysis. Treatment Outcome

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  • (PMID = 19036691.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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14. Ahmadi A, Mohagheghi M, Karimi M, Seyed Ali Golestanha, Naseri M: Anticancer effects of HESA-A in patients with metastatic colon cancer. Integr Cancer Ther; 2009 Mar;8(1):71-4
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  • [Title] Anticancer effects of HESA-A in patients with metastatic colon cancer.
  • The aim of this study was to investigate the therapeutic effects of HESA-A in patients with metastatic colon cancer.
  • METHODS: Fifty consecutive patients with end-stage colon cancer and liver metastasis at the Cancer Research Center of Tehran University of Medical Sciences were studied.
  • [MeSH-minor] Adult. Aged. Cancer Care Facilities. Female. Humans. Iran / epidemiology. Karnofsky Performance Status. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Male. Middle Aged. Prospective Studies

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  • (PMID = 19147644.001).
  • [ISSN] 1534-7354
  • [Journal-full-title] Integrative cancer therapies
  • [ISO-abbreviation] Integr Cancer Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / HESA-A preparation; 0 / Plant Preparations
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15. Manuelli M, De Luca L, Iaria G, Tatangelo P, Sforza D, Perrone L, Bellini MI, Angelico R, Anselmo A, Tisone G: Conversion to rapamycin immunosuppression for malignancy after kidney transplantation. Transplant Proc; 2010 May;42(4):1314-6
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  • Rapamycin has been shown to limit the proliferation of a number of malignant cell lines in vivo and in vitro.
  • METHODS: Fifteen patients developed the following malignancies at a mean of 90.3 months (range = 10-252) after kidney transplantation: metastatic gastric cancer (n = 1), metastatic colon cancer (n = 1), bilateral nephrourothelioma (n = 1), skin cancer (n = 2), Kaposi's sarcoma (n = 2), posttransplant lymphoproliferative disorder (PTLD; n = 4), renal cell carcinoma T1 (n = 1), MALT lymphoma (n = 1), intramucous colon carcinoma (n = 1), liposarcoma of the spermatic cord (n = 1).
  • RESULTS: Both patients with metastatic cancer underwent chemotherapy but succumbed after 6 and 13 months.
  • At a mean follow-up of 32.7 months (range = 7-56), the remaining 11 patients are cancer-free.
  • [MeSH-minor] Cell Division / drug effects. Cell Line, Tumor. Colonic Neoplasms / immunology. Colonic Neoplasms / pathology. Genital Neoplasms, Male / immunology. Genital Neoplasms, Male / pathology. Humans. Immunosuppression / methods. Immunosuppressive Agents / therapeutic use. Liposarcoma / immunology. Liposarcoma / pathology. Male. Neoplasm Metastasis. Skin Neoplasms / immunology. Skin Neoplasms / pathology. Stomach Neoplasms / immunology. Stomach Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010. Published by Elsevier Inc.
  • (PMID = 20534289.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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16. Iwazawa J, Ohue S, Hashimoto N, Yasumasa K, Abe H, Mitani T: Bevacizumab-induced hypovascular hepatocellular carcinoma treated by transarterial chemoembolization in a patient with metastatic colon cancer. J Vasc Interv Radiol; 2010 Mar;21(3):412-4
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  • [Title] Bevacizumab-induced hypovascular hepatocellular carcinoma treated by transarterial chemoembolization in a patient with metastatic colon cancer.

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  • (PMID = 20116287.001).
  • [ISSN] 1535-7732
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 2S9ZZM9Q9V / Bevacizumab
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17. Hiraki M, Yakushiji H, Hashiguchi K, Harada S: [Combination chemotherapy with oral TS-1 and low-dose CPT-11 by hepatic arterial infusion for multiple hepatic metastases from colon cancer--a case report]. Gan To Kagaku Ryoho; 2005 Jul;32(7):1055-8
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  • [Title] [Combination chemotherapy with oral TS-1 and low-dose CPT-11 by hepatic arterial infusion for multiple hepatic metastases from colon cancer--a case report].
  • Combined chemotherapy consisting of oral TS-1 and low-dose CPT-11 by hepatic arterial infusion is suggested to be a new effective treatment for multiple liver metastases from colorectal cancer.
  • A 53-year-old man was diagnosed with multiple hepatic metastases from advanced colon cancer (Stage IV).
  • The patient underwent partial resection of the colon and catheter insertion into hepatic artery for arterial infusion in November 2003.
  • In spite of the reduction of metastatic liver tumors after 2 cycles of the chemotherapy, a metastatic pleural tumor appeared.

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  • (PMID = 16044973.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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18. Papila B, Yildiz O, Tural D, Delil S, Hasiloglu ZI, Ayan F, Papila C: Wernicke's Encephalopathy in Colon Cancer. Case Rep Oncol; 2010;3(3):362-7
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  • [Title] Wernicke's Encephalopathy in Colon Cancer.
  • In this case report, we present a 56-year-old female patient with metastatic colon cancer complicated with enterocutaneous fistula.

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  • (PMID = 21537379.001).
  • [ISSN] 1662-6575
  • [Journal-full-title] Case reports in oncology
  • [ISO-abbreviation] Case Rep Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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  • [Keywords] NOTNLM ; 5-fluorouracil / Thiamine / Wernicke's encephalopathy
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19. Burz C, Berindan-Neagoe IB, Balacescu O, Tanaselia C, Ursu M, Gog A, Vlase L, Chintoanu M, Balacescu L, Leucuta SE, Irimie A, Cristea V: Clinical and pharmacokinetics study of oxaliplatin in colon cancer patients. J Gastrointestin Liver Dis; 2009 Mar;18(1):39-43
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  • [Title] Clinical and pharmacokinetics study of oxaliplatin in colon cancer patients.
  • AIM: to evaluate the therapeutic efficacy of oxaliplatin and to analyze the pharmacokinetics of both ultrafiltrable (free) and protein-bound platinum in patients with metastatic colon cancer.
  • METHOD: 60 patients with stage IV colon carcinoma received 4-6 (mean 4.5) cycles of oxaliplatin based combination chemotherapy.
  • CONCLUSION: Oxaliplatin is active and well tolerated in patients with advanced colon cancer.
  • [MeSH-minor] Adult. Aged. Area Under Curve. Disease-Free Survival. Dose-Response Relationship, Drug. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Fluorouracil / blood. Fluorouracil / pharmacokinetics. Humans. Infusions, Intravenous. Leucovorin / administration & dosage. Leucovorin / adverse effects. Leucovorin / blood. Leucovorin / pharmacokinetics. Male. Mass Spectrometry. Metabolic Clearance Rate. Middle Aged. Neoplasm Staging. Protein Binding. Time Factors. Treatment Outcome

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  • (PMID = 19337632.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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20. Agarwal V, Sgouros J, Smithson J, Lodge JP, Razack A, Campbell A, Maraveyas A: Sinusoidal obstruction syndrome (veno-occlusive disease) in a patient receiving bevacizumab for metastatic colorectal cancer: a case report. J Med Case Rep; 2008;2:227
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  • [Title] Sinusoidal obstruction syndrome (veno-occlusive disease) in a patient receiving bevacizumab for metastatic colorectal cancer: a case report.
  • INTRODUCTION: We present the case of a patient with colon cancer who, while receiving bevacizumab, developed sinusoidal obstruction syndrome (veno-occlusive disease) (SOSVOD).
  • CASE PRESENTATION: A 77-year-old man was being treated with oxaliplatin and a modified de Gramont regimen of 5-fluorouracil for metastatic colon cancer.

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  • [ISO-abbreviation] J Med Case Rep
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21. Kishimoto H, Urata Y, Tanaka N, Fujiwara T, Hoffman RM: Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Mol Cancer Ther; 2009 Nov;8(11):3001-8
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  • [Title] Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses.
  • We assessed the antitumor efficacy of OBP-301 and the ability of OBP-401 to deliver GFP in hepatocellular carcinoma (HCC) and metastatic colon cancer nude mouse models.
  • We showed that i.v. administration of OBP-301 significantly inhibited colon cancer liver metastases and orthotopically implanted HCC.

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  • (PMID = 19887549.001).
  • [ISSN] 1538-8514
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R43 CA132242; United States / NCI NIH HHS / CA / CA132242
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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22. Kim HW, Won KS, Kwon KY, Choi BW, Zeon SK: Metastatic colon cancer to the lung with no detectable primary tumor, mimicking advanced primary lung cancer on F-18 FDG PET/CT imaging. Clin Nucl Med; 2010 Mar;35(3):184-6
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  • [Title] Metastatic colon cancer to the lung with no detectable primary tumor, mimicking advanced primary lung cancer on F-18 FDG PET/CT imaging.
  • CT-guided biopsy of the right lung mass revealed metastatic adenocarcinoma from the colon, but a colon cancer lesion was not detected by dynamic abdominal CT and colonoscopy.

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  • (PMID = 20173453.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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23. Shoji H, Kuroki M, Hiramoto K, Matsumura Y, Miura A, Kikuchi Y, Hirakawa H: [A case of metastatic colorectal cancer suffering from hyperammonemic encephalopathy induced by 5-FU, continuously treated with FOLFOX therapy]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1583-6
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  • [Title] [A case of metastatic colorectal cancer suffering from hyperammonemic encephalopathy induced by 5-FU, continuously treated with FOLFOX therapy].
  • We report a rare case of metastatic colorectal cancer who suffered from hyperammonemic encephalopathy induced by 5- FU and was continuously treated with FOLFOX therapy.
  • A 50-year-old man with ileus was diagnosed with ascending colon cancer Stage IV, and a right hemicolectomy was performed.

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  • (PMID = 20716892.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Amino Acids, Branched-Chain; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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24. Holen KD: Target practice: figuring out which, when, and why to use systemic therapies for metastatic colon cancer. Cancer Invest; 2006 Feb;24(1):98-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Target practice: figuring out which, when, and why to use systemic therapies for metastatic colon cancer.
  • There have been many recent advances in the field of systemic chemotherapy for metastatic colorectal cancer.
  • Although the decision regarding colorectal cancer chemotherapy is now more complicated, our patients have certainly benefited from better response rates and most importantly, longer survival times.

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  • (PMID = 16466998.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Vascular Endothelial Growth Factor A; 9007-49-2 / DNA; EC 2.1.1.45 / Thymidylate Synthase; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 5.99.1.2 / DNA Topoisomerases, Type I; U3P01618RT / Fluorouracil
  • [Number-of-references] 59
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25. Castillo-Fernández O, Santibáñez M, Bauza A, Calderillo G, Castro C, Herrera R, Serrano A, Arrieta O, Herrera LA: Methylenetetrahydrofolate reductase polymorphism (677 C&gt;T) predicts long time to progression in metastatic colon cancer treated with 5-fluorouracil and folinic acid. Arch Med Res; 2010 Aug;41(6):430-5
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  • [Title] Methylenetetrahydrofolate reductase polymorphism (677 C>T) predicts long time to progression in metastatic colon cancer treated with 5-fluorouracil and folinic acid.
  • BACKGROUND AND AIMS: Fluoropyrimidine-based chemotherapy is the most common treatment for unresectable metastatic colorectal cancer (m-CRC).
  • Pharmacogenomics allows the tailoring of cancer therapy to the patient.

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  • [Copyright] Copyright © 2010 IMSS. Published by Elsevier Inc. All rights reserved.
  • (PMID = 21044746.001).
  • [ISSN] 1873-5487
  • [Journal-full-title] Archives of medical research
  • [ISO-abbreviation] Arch. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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26. Kurtz JE, Claudel L, Collard O, Limacher JM, Bergerat JP, Dufour P: Liver abscess due to clostridium septicum. A case report and review of the literature. Hepatogastroenterology; 2005 Sep-Oct;52(65):1557-8
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  • The onset of liver abscess due to Clostridium septicum -an anaerobic gram-positive bacillus- is a rare condition, generally arising in cancer patients.
  • We report a case of a 50-year-old patient with metastatic colon cancer who was referred with multiple Clostridium septicum liver abscesses.
  • Clostridium septicum liver abscess is a life-threatening condition that occurs in fragile patients, mostly with metastatic cancers.

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  • (PMID = 16201118.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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27. Vaidyanathan G, Fakih MG: A case of curative-intent hepatectomy for colon cancer metastatic to the scapula and liver. Anticancer Res; 2010 Feb;30(2):677-9
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  • [Title] A case of curative-intent hepatectomy for colon cancer metastatic to the scapula and liver.
  • Colon cancer is the second leading cause of cancer death in the United States.
  • Patients with colon cancer metastatic to liver and bone are deemed non-curable and have a poor prognosis.
  • We present a case of recurrent colon cancer with synchronous hepatic and bony metastases treated with radiation, chemotherapy, and curative-intent hepatectomy.


28. Tscharner GG, Bühler S, Borner M, Hunziker T: Grover's disease induced by cetuximab. Dermatology; 2006;213(1):37-9
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  • A 71-year-old man exhibited an acute acneiform rash affecting the face and the upper trunk about 2 weeks after starting cetuximab, an epidermal growth factor (EGF) receptor antagonist treatment for metastatic colon cancer.

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  • (PMID = 16778425.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab
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29. Xu F, Ye YJ, Liu W, Kong M, He Y, Wang S: Dendritic cell/tumor hybrids enhances therapeutic efficacy against colorectal cancer liver metastasis in SCID mice. Scand J Gastroenterol; 2010 Jun;45(6):707-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dendritic cell/tumor hybrids enhances therapeutic efficacy against colorectal cancer liver metastasis in SCID mice.
  • OBJECTIVE: Colorectal cancer (CRC) is one of the most common malignancies in the western world.
  • Although surgical resection is the first choice worldwide, at this point an effective approach for the treatment of patients with liver metastasis and cancer recurrence postoperation has not yet been found.
  • The aim of this study is to investigate the role of the allogeneic dendritomas from fusion of DCs and metastatic colon cancer cells in the activation of anti-tumor immunity against colorectal cancer liver metastases.
  • MATERIAL AND METHODS: Hybrids were generated by fused allogeneic human peripheral blood dendritic cells with metastatic colon cancer SW620 cells using 50% polyethylene glycol (PEG).
  • CONCLUSIONS: Vaccination with hybrids can induces strong cellular responses and significant protection from challenge in SCID mouse metastatic CRC model.


30. Garufi C, Ettorre GM, Vanni B, Torsello A, Terzoli E: Neoadjuvant chemotherapy for metastatic colon cancer: too much caution and still too much to be assessed. J Clin Oncol; 2006 May 10;24(14):2217-8; author reply 2218-9
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  • [Title] Neoadjuvant chemotherapy for metastatic colon cancer: too much caution and still too much to be assessed.
  • [MeSH-minor] Humans. Neoadjuvant Therapy. Neoplasm Metastasis

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  • [CommentOn] J Clin Oncol. 2005 Dec 20;23(36):9073-8 [16361615.001]
  • (PMID = 16682743.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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31. Mis L, Fernando NH, Hurwitz HI, Morse MA: Successful desensitization to oxaliplatin. Ann Pharmacother; 2005 May;39(5):966-9
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  • CASE SUMMARY: A 53-year-old white woman with metastatic colon cancer was receiving oxaliplatin, bevacizumab, and capecitabine every 2 weeks, with a partial response to therapy.
  • CONCLUSIONS: Hypersensitivity reactions to platinum compounds may result in discontinuation of active therapies in patients with metastatic disease.

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  • (PMID = 15784807.001).
  • [ISSN] 1060-0280
  • [Journal-full-title] The Annals of pharmacotherapy
  • [ISO-abbreviation] Ann Pharmacother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin
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32. McCormick CC, Giuntoli RL 2nd, Gardner GJ, Schulick RD, Judson K, Ronnett BM, Vang R, Bristow RE: The role of cytoreductive surgery for colon cancer metastatic to the ovary. Gynecol Oncol; 2007 Jun;105(3):791-5
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  • [Title] The role of cytoreductive surgery for colon cancer metastatic to the ovary.
  • OBJECTIVE: We sought to further elucidate the survival impact of cytoreductive surgery among patients with colon cancer metastatic to the ovary.
  • METHODS: All women diagnosed with primary colon cancer metastatic to the ovary at a single institution from 1980 to 2005 were retrospectively identified.
  • RESULTS: A total of 39 patients with 40 cases of colon cancer metastatic to the ovary were identified.
  • Patients with metastatic disease confined to the ovaries (n=11) had a median overall survival (OS) time of 61 months (range 15-120) compared to 17 months (range 0.5-73) for those with more extensive metastases (n=24) (p=0.0428).
  • CONCLUSIONS: The observation that optimal cytoreduction was associated with prolonged PFS and OS in both patients with localized ovarian and widespread metastases of colon cancer suggests a role for surgical management of metastatic colon cancer in women.

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  • (PMID = 17408727.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Berber E, Siperstein AE: Perioperative outcome after laparoscopic radiofrequency ablation of liver tumors: an analysis of 521 cases. Surg Endosc; 2007 Apr;21(4):613-8
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  • BACKGROUND: Radiofrequency thermal ablation (RFA) is gaining increased acceptance for the treatment of unresectable primary and metastatic liver tumors.
  • The pathology was metastatic colon cancer for 244 patients (47%), hepatocellular cancer for 109 patients (21%), metastatic neuroendocrine cancer for 74 patients (14%), and other noncolorectal, nonneuroendocrine liver metastasis for 94 patients (18%).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Biopsy, Needle. Cohort Studies. Female. Follow-Up Studies. Hepatectomy / methods. Humans. Immunohistochemistry. Liver Function Tests. Male. Middle Aged. Neoplasm Staging. Perioperative Care. Probability. Prospective Studies. Regression Analysis. Risk Assessment. Survival Analysis. Treatment Outcome

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  • [Cites] Surg Endosc. 2000 Apr;14(4):400-5 [10790563.001]
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  • (PMID = 17287917.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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34. Thomas A, Lenox R: Pulmonary lymphangitic carcinomatosis as a primary manifestation of colon cancer in a young adult. CMAJ; 2008 Aug 12;179(4):338-40
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  • [Title] Pulmonary lymphangitic carcinomatosis as a primary manifestation of colon cancer in a young adult.
  • Pulmonary lymphangitic carcinomatosis is a metastatic lung disease characterized by diffuse spread of the tumour to the pulmonary lymphatic system.
  • However, results of a transbronchial biopsy led to the diagnosis of pulmonary lymphangitic carcinomatosis from metastatic colon cancer.

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  • [Cites] CA Cancer J Clin. 2002 Jan-Feb;52(1):23-47 [11814064.001]
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  • (PMID = 18695182.001).
  • [ISSN] 1488-2329
  • [Journal-full-title] CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • [ISO-abbreviation] CMAJ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2492966
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35. Chennat J, Waxman I: Initial performance profile of a new 6F self-expanding metal stent for palliation of malignant hilar biliary obstruction. Gastrointest Endosc; 2010 Sep;72(3):632-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Initial performance profile of a new 6F self-expanding metal stent for palliation of malignant hilar biliary obstruction.
  • BACKGROUND: A 6F endoscopic biliary self-expanding metal stent (SEMS) has been newly introduced for intended simultaneous side-by-side bilateral deployment in hilar malignant obstruction.
  • PATIENTS: Sixteen consecutive malignant hilar biliary obstruction patients.
  • INTERVENTIONS: Endoscopic palliative treatment of malignant biliary obstruction with the Zilver 635 SEMS from December 2008 to January 2010.
  • RESULTS: A total of 49 Zilver SEMSs were placed in 16 patients (mean age 61 years, 6 men) for Bismuth type II (n = 4), III (n = 5), and IV (n = 7) lesions.
  • Twelve had cholangiocarcinoma, 2 had metastatic colon cancer, 1 had lung cancer, and 1 had pancreatic cancer.
  • CONCLUSIONS: Malignant hilar biliary obstruction endoscopic palliation with the Zilver 635 SEMS offers acceptable initial feasibility, safety, and efficacy profiles.

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  • [Copyright] Copyright 2010. Published by Mosby, Inc.
  • (PMID = 20579991.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alloys; 52013-44-2 / nitinol
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36. Damjanov N: Commentary: Colonoscopic findings and tumor site do not predict bowel obstruction during medical treatment of stage IV colon cancer. Oncologist; 2009 Jun;14(6):578-9
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  • [Title] Commentary: Colonoscopic findings and tumor site do not predict bowel obstruction during medical treatment of stage IV colon cancer.
  • [MeSH-minor] Humans. Neoplasm Staging

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  • [CommentOn] Oncologist. 2009 Jun;14(6):580-5 [19465681.001]
  • (PMID = 19482957.001).
  • [ISSN] 1549-490X
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
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37. Hsu TC: Unusual elevation of CEA in a patient with history of colon cancer. Jpn J Clin Oncol; 2006 Dec;36(12):811-3
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  • [Title] Unusual elevation of CEA in a patient with history of colon cancer.
  • A 35-year-old female received right hemicolectomy for a poorly differentiated adenocarcinoma of the ascending colon with lymph node metastasis (1/28) in February 1997.
  • She received bilateral salpingo-ophorecctomy for metastatic cancer in August 1999.
  • CEA was found to be 240.3 ng/microl in December 1999 and then elevated to 1521.3 ng/microl in June 2001, which was 10 months after resection of metastatic ovarian cancer.
  • No metastatic lesions could be detected, however, with image studies.
  • The current case suggested that: (i) elevation of CEA is not necessarily well correlated with presence of metastatic colon cancer;.

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  • (PMID = 17060406.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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38. Iacovazzi PA, Notarnicola M, Caruso MG, Guerra V, Frisullo S, Altomare DF, Correale M: Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients. Immunopharmacol Immunotoxicol; 2010 Mar;32(1):160-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients.
  • In our study, we have evaluated levels of both glycoproteins in sera of non metastatic colon cancer patients.
  • Interestingly, galectin-3 ranged higher in cancer patients than in controls (p<0.0001), particularly in more differentiated tumors (p<0.04).
  • Moreover, 90K mean values ranged higher in right-side than in left-side colon cancer.
  • In conclusion, serum galectin3 might represent a useful biomarker to evaluate colon cancer transformation and, together with its ligand 90K, could contribute to the characterization of colon cancer.
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, Neoplasm. Biomarkers, Tumor. Female. Galectin 3 / blood. Humans. Male. Middle Aged

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  • (PMID = 19686089.001).
  • [ISSN] 1532-2513
  • [Journal-full-title] Immunopharmacology and immunotoxicology
  • [ISO-abbreviation] Immunopharmacol Immunotoxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Galectin 3; 0 / Glycoproteins; 0 / LGALS3BP protein, human
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39. Lasalvia-Prisco E, Garcia-Giralt E, Cucchi S, Vázquez J, Lasalvia-Galante E, Golomar W, Larrañga J: Advanced colon cancer: antiprogressive immunotherapy using an autologous hemoderivative. Med Oncol; 2006;23(1):91-104
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  • [Title] Advanced colon cancer: antiprogressive immunotherapy using an autologous hemoderivative.
  • INTRODUCTION: Advanced colon cancer patients, acquired-chemotherapy resistant and in progression, are therapeutically terminal.
  • PATIENTS AND METHODS: Metastatic colon cancer patients chemotherapy-resistant, high CEA plasma levels, in progression, were 2-group randomized.
  • CONCLUSION: The autologous hemoderivative tested is antigenically polyvalent and promotes a polytargeted immune response associated with a tumor antiprogressive effect, consequently, acting as an autologous hemoderivative cancer vaccine.

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  • (PMID = 16645234.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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40. Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, Rougier P, Lievre A, Landi B, Boige V, Ducreux M, Ychou M, Bibeau F, Bouché O, Reid J, Stone S, Penault-Llorca F: Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol; 2009 Dec 10;27(35):5924-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.
  • PURPOSE: The occurrence of KRAS mutation is predictive of nonresponse and shorter survival in patients treated by anti-epidermal growth factor receptor (anti-EGFR) antibody for metastatic colorectal cancer (mCRC), leading the European Medicine Agency to limit its use to patients with wild-type KRAS tumors.


41. Andreis F, Rizzi A, Mosconi P, Braun C, Rota L, Meriggi F, Mazzocchi M, Zaniboni A: Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study. Health Qual Life Outcomes; 2010;8:40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality of life in colon cancer patients with skin side effects: preliminary results from a monocentric cross sectional study.
  • This monocentric cross sectional study is carried out to assess quality of life in colon cancer patients experienced skin side effects due to anti epidermal growth factor receptor inhibitors therapy.
  • RESULTS: Forty-five consecutive patients, mainly with metastatic colon cancer (29 female, 16 male), with an average age of 59.31 years (ranging from 34-78) were included in the study and analyzed.
  • CONCLUSIONS: Epidermal growth factor receptor inhibitors' skin side effects have an important impact on quality of life in advanced colon cancer patients; symptoms scale is the most effect respect to emotional and functioning scales.

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  • (PMID = 20398332.001).
  • [ISSN] 1477-7525
  • [Journal-full-title] Health and quality of life outcomes
  • [ISO-abbreviation] Health Qual Life Outcomes
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC2861022
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42. Correale P, Cusi MG, Tsang KY, Del Vecchio MT, Marsili S, Placa ML, Intrivici C, Aquino A, Micheli L, Nencini C, Ferrari F, Giorgi G, Bonmassar E, Francini G: Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients. J Clin Oncol; 2005 Dec 10;23(35):8950-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients.
  • An immunologic study of peripheral blood mononuclear cells (PBMCs) taken from 20 patients showed an enhanced proliferative response to colon carcinoma antigen and a significant reduction in suppressive regulatory T lymphocytes (CD4+CD25T-reg+).
  • CONCLUSION: The results show that our regimen has strong immunologic and antitumor activity in colorectal cancer patients and deserves to be investigated in phase III trials.
  • [MeSH-minor] Aged. Antigens, Neoplasm / immunology. Carcinoembryonic Antigen / immunology. Cytotoxicity, Immunologic / drug effects. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Disease Progression. Female. Flow Cytometry. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Humans. Infusions, Intravenous. Interleukin-2 / administration & dosage. Interleukin-2 / adverse effects. Leucovorin / administration & dosage. Leucovorin / adverse effects. Male. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / adverse effects. T-Lymphocytes, Regulatory / drug effects. T-Lymphocytes, Regulatory / immunology. Thymidylate Synthase / immunology. Treatment Outcome

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  • (PMID = 16061910.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carcinoembryonic Antigen; 0 / Interleukin-2; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor; B76N6SBZ8R / gemcitabine; EC 2.1.1.45 / Thymidylate Synthase; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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43. Takahashi S, Nagai K, Saito N, Konishi M, Nakagohri T, Gotohda N, Nishimura M, Yoshida J, Kinoshita T: Multiple resections for hepatic and pulmonary metastases of colorectal carcinoma. Jpn J Clin Oncol; 2007 Mar;37(3):186-92
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  • BACKGROUND: Resections are effective for some patients with both hepatic and pulmonary metastases of colorectal cancer, but the best selection criteria for the resections and effective treatment for recurrence after the resections have not been determined.
  • METHODS: A retrospective analysis was performed for 30 consecutive patients who received aggressive multiple resections for both hepatic and pulmonary metastases of colorectal cancer.
  • Multivariate analyses revealed that primary colon cancer, stage IV in TNM classification and maximum size of hepatic tumor >3 cm at initial hepatectomy were poor prognostic factors, but several long-term survivors were observed even among patients with those factors.
  • CONCLUSIONS: Multiple resections for hepatic and pulmonary metastases of colorectal cancer are safe and effective.
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Female. Hepatectomy. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local / surgery. Pneumonectomy. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17472970.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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44. Iwashita Y, Sasaki A, Matsumoto T, Shibata K, Inomata M, Ohta M, Kitano S: Two-stage laparoscopic resection of colon cancer and metastatic liver tumour. J Minim Access Surg; 2005 Mar;1(1):37-8
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  • [Title] Two-stage laparoscopic resection of colon cancer and metastatic liver tumour.
  • We report herein the case of 70-year-old woman in whom colon cancer and a synchronous metastatic liver tumour were successfully resected laparoscopically.

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  • [Cites] Arch Surg. 2000 Apr;135(4):473-9; discussion 479-80 [10768715.001]
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  • (PMID = 21234143.001).
  • [ISSN] 0972-9941
  • [Journal-full-title] Journal of minimal access surgery
  • [ISO-abbreviation] J Minim Access Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3016475
  • [Keywords] NOTNLM ; Colorectal cancer / laparoscopic hepatectomy / laparoscopy-assisted colectomy / metastatic liver tumour
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45. Shaikh A, Wiisanen ME, Gunderson HD, Leung N: Acquired Fanconi syndrome after treatment with capecitabine, irinotecan, and bevacizumab. Ann Pharmacother; 2009 Jul;43(7):1370-3
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  • CASE SUMMARY: A 77-year-old female with metastatic colon cancer presented with vomiting and diarrhea.
  • The patient had been diagnosed with stage IIIC (T3, N2, M0) colon cancer 18 months earlier and was initially treated with FOLFOX6 (regimen of oxaliplatin, fluorouracil, and leucovorin) after her hemicolectomy.
  • She did well until 10 months after her cancer diagnosis, when metastasis was discovered.

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  • (PMID = 19584382.001).
  • [ISSN] 1542-6270
  • [Journal-full-title] The Annals of pharmacotherapy
  • [ISO-abbreviation] Ann Pharmacother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; 6804DJ8Z9U / Capecitabine; 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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46. Cohen DJ, Hochster HS: Update on clinical data with regimens inhibiting angiogenesis and epidermal growth factor receptor for patients with newly diagnosed metastatic colorectal cancer. Clin Colorectal Cancer; 2007 Dec;7 Suppl 1:S21-7
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  • [Title] Update on clinical data with regimens inhibiting angiogenesis and epidermal growth factor receptor for patients with newly diagnosed metastatic colorectal cancer.
  • As a result of the development of novel chemotherapeutic drugs and targeted biologic agents, the treatment of colon cancer has changed significantly over the past 10 years.
  • Today, we have more active agents to use in colon cancer than ever before.
  • At present, patients with metastatic colon cancer routinely achieve a median survival time > 2 years.
  • Herein, we review the 2 main molecular targets of biologic therapy in colon cancer and examine the clinical evidence for regimens that inhibit angiogenesis and EGF receptor alone or in combination for newly diagnosed metastatic colorectal cancer.

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  • (PMID = 18361803.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 0 / Vascular Endothelial Growth Factor A; 04ZR38536J / oxaliplatin; 0H43101T0J / irinotecan; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; 6804DJ8Z9U / Capecitabine; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 34
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47. Funaioli C, Pinto C, Di Fabio F, Santini D, Ceccarelli C, De Raffaele E, Fanti S, Castellucci P, Longobardi C, Buggi F, Martoni AA: 18FDG-PET evaluation correlates better than CT with pathological response in a metastatic colon cancer patient treated with bevacizumab-based therapy. Tumori; 2007 Nov-Dec;93(6):611-5
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  • [Title] 18FDG-PET evaluation correlates better than CT with pathological response in a metastatic colon cancer patient treated with bevacizumab-based therapy.
  • Around 20-30% of patients with hepatic metastasis from colorectal cancer can undergo liver resection, but the increased response rate obtained with the addition of monoclonal antibodies to chemotherapy regimens could result in a higher rate of liver surgery.
  • New specific studies are required to evaluate the imaging response in metastatic colorectal cancer patients especially after treatment with new, targeted agents.

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  • (PMID = 18338499.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 0 / Radiopharmaceuticals; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 2S9ZZM9Q9V / Bevacizumab; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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48. Alessandro R, Seidita G, Flugy AM, Damiani F, Russo A, Corrado C, Colomba P, Gullotti L, Buettner R, Bruno L, De Leo G: Role of S128R polymorphism of E-selectin in colon metastasis formation. Int J Cancer; 2007 Aug 1;121(3):528-35
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  • [Title] Role of S128R polymorphism of E-selectin in colon metastasis formation.
  • The extravasation of cancer cells is a key step of the metastatic cascade.
  • Polymorphisms in genes encoding adhesion molecules can facilitate metastasis by increasing the strength of interaction between tumor and endothelial cells as well as impacting other properties of cancer cells.
  • We investigated the Ser128Arg (a561c at the nucleotide level) polymorphism in the E-selectin gene in patients with metastatic colon cancer and its functional significance.
  • Genotyping for a561c polymorphism was performed on 172 cancer patients and on an age-matched control population.
  • The colon cancer group was divided into groups with (M(+)) and without observable metastasis (M(-)).
  • For in vitro functional assays, Huvec transfected cells expressing wild-type (WT) or the S128R variant of E-selectin were established to study in vitro binding ability and signal transduction processes of T84 colon cancer cell line.
  • In vitro, S128R E-selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signaling of T84 cancer cells compared to WT E-selectin and mock-transfected Huvec cells.
  • These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype.
  • [MeSH-major] Colonic Neoplasms / genetics. E-Selectin / genetics. Neoplasm Metastasis / genetics. Polymorphism, Genetic

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  • [Copyright] Copyright (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17372905.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / E-Selectin; 452VLY9402 / Serine; 94ZLA3W45F / Arginine
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49. Foster JA, Salinas GD, Mansell D, Williamson JC, Casebeer LL: How does older age influence oncologists' cancer management? Oncologist; 2010;15(6):584-92
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  • [Title] How does older age influence oncologists' cancer management?
  • BACKGROUND: Over half of new cancer cases occur in patients aged > or = 65 years.
  • Many older patients can benefit from intensive cancer therapies, yet evidence suggests that this population is undertreated.
  • METHODS: To assess preferences and influential factors in geriatric cancer management, practicing U.S. medical oncologists completed a survey containing four detailed vignettes exploring colon, breast, lung, and prostate cancer treatment.
  • For a woman with metastatic colon cancer (Eastern Cooperative Oncology Group [ECOG] score, 1) for whom chemotherapy was recommended, nearly all oncologists chose an intensive regimen if the patient's age was 63; but if her age was 85, one fourth of the oncologists chose a less intensive treatment.
  • Likewise, for stage IIA breast cancer (ECOG score, 0), 93% recommended intensive adjuvant treatment for a previously healthy patient aged 63; but only 66% said they would do so if the patient's age was 75.
  • CONCLUSIONS: Advanced age can deter oncologists from choosing intensive cancer therapy, even if patients are highly functional and lack comorbidities.
  • Education on tailoring cancer treatment and a greater use of comprehensive geriatric assessment may reduce cancer undertreatment in the geriatric population.


50. Heinzerling JH, Huerta S: Bowel perforation from bevacizumab for the treatment of metastatic colon cancer: incidence, etiology, and management. Curr Surg; 2006 Sep-Oct;63(5):334-7
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  • [Title] Bowel perforation from bevacizumab for the treatment of metastatic colon cancer: incidence, etiology, and management.
  • Avastin (Bevacizumab) is a recently developed monoclonal antibody against vascular endothelial growth factor (VEGF) receptor that increases survival in patients with metastatic colorectal cancer.
  • [MeSH-major] Abdomen, Acute / chemically induced. Adenocarcinoma / drug therapy. Angiogenesis Inhibitors / adverse effects. Antibodies, Monoclonal / adverse effects. Intestinal Perforation / chemically induced. Neoplasm Recurrence, Local / drug therapy. Rectal Neoplasms / drug therapy

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  • (PMID = 16971205.001).
  • [ISSN] 0149-7944
  • [Journal-full-title] Current surgery
  • [ISO-abbreviation] Curr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab
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51. Tsujie M, Fujiwara S, Kida H, Hayashi N, Fukuchi S, Yoshida T, Ebisui C, Sakita I, Hasuike Y, Fujimoto T: [A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy]. Gan To Kagaku Ryoho; 2005 Oct;32(11):1774-5
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  • [Title] [A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy].
  • A 77-year-old male had been operated for ascending colon cancer with liver metastases.
  • We conclude that the oxaliplatin-based chemotherapy may be useful for patients suffering 5-FU and CPT-11 resistant metastatic colorectal cancer in Japan.

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  • (PMID = 16315937.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Organoplatinum Compounds; 039LU44I5M / Floxuridine; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; V1JK16Y2JP / doxifluridine; XT3Z54Z28A / Camptothecin
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52. Shin KS, Hong SB, Son BR: [A Case of Catheter-Related Bacteremia by Arthrobacter woluwensis.]. Korean J Lab Med; 2006 Apr;26(2):103-6
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  • Arthrobacter woluwensis, a catalase-positive coryneform bacterium recognized as an opportunistic pathogen, was repeatedly isolated from the blood of a 56-year-old male patient with metastatic colon cancer.

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  • (PMID = 18156709.001).
  • [ISSN] 1598-6535
  • [Journal-full-title] The Korean journal of laboratory medicine
  • [ISO-abbreviation] Korean J Lab Med
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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53. Guess CM, Lafleur BJ, Weidow BL, Quaranta V: A decreased ratio of laminin-332 beta3 to gamma2 subunit mRNA is associated with poor prognosis in colon cancer. Cancer Epidemiol Biomarkers Prev; 2009 May;18(5):1584-90
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  • [Title] A decreased ratio of laminin-332 beta3 to gamma2 subunit mRNA is associated with poor prognosis in colon cancer.
  • Herein, we test the hypothesis that mRNA changes in one or more Ln-332 encoding genes can be used to distinguish between early- and advanced-stage cancer specimens and shed light on mechanistic questions raised by previous studies.
  • Statistical analyses of human microarray data from the publicly available expression project in Oncology (expO) dataset, including examination of the distributions of Ln-332 subunit mRNA levels, identified a significant decrease in the Ln-332 beta3:gamma2 mRNA ratio between normal (n = 10) and early-stage colon cancer (n = 29) specimens.
  • The beta3:gamma2 ratio was further decreased in metastatic colon cancer (n = 41) compared with early-stage samples.
  • Our findings raise the possibility that Ln-332 gamma2 may be a therapeutic target against metastatic colon cancer because a lowered beta3:gamma2 ratio would reduce expression of heterotrimeric Ln-332 and increase monomeric gamma2 secretion.

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  • (PMID = 19383890.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U54 CA113007; United States / NCI NIH HHS / CA / R01 CA047858; United States / NCI NIH HHS / CA / R01 CA047858-19; United States / NCI NIH HHS / CA / U54 CA113007-04S1; United States / NCI NIH HHS / CA / CA113007-04S1; United States / NCI NIH HHS / CA / CA047858-19; United States / NCI NIH HHS / CA / 3U54CA11300702S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / RNA, Messenger; 0 / kalinin
  • [Other-IDs] NLM/ NIHMS200776; NLM/ PMC2869450
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54. Tsouma A, Aggeli C, Lembessis P, Zografos GN, Korkolis DP, Pectasides D, Skondra M, Pissimissis N, Tzonou A, Koutsilieris M: Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients. World J Gastroenterol; 2010 Dec 21;16(47):5965-74
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  • [Title] Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients.
  • AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting circulating tumor cells in the peripheral blood of colorectal cancer (CRC) patients.
  • The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival.
  • The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P < 0.001) and preoperative serum levels of CEA (P = 0.029) in CRC patients.
  • CONCLUSION: These data suggest that multiplex RT-PCR assay can provide useful information concerning disease stage and overall survival of CRC patients.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 21157973.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-20; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC3007112
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55. Ohsawa I, Murakami T, Uemoto S, Kobayashi E: In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats. Transplantation; 2006 Jun 15;81(11):1558-67
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  • [Title] In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats.
  • BACKGROUND: Immunosuppressed individuals undergoing organ transplantation are at increased risk of recurrences of initial cancers, although how immunosuppressive therapy increases early cancer metastasis remains unclear.
  • METHODS: The metastatic fate of luciferase-expressing rat metastatic colon cancer cells (luc-RCN-H4) injected intravenously into the liver of syngeneic and allogeneic rats was examined in the presence of the immunosuppressant cyclosporin A (CsA) by in vivo luminescent technique.
  • CONCLUSIONS: Whereas the chemokine receptor expression by cancer cells is implicated with early organotropic dissemination even under CsA-mediated immune suppression, rather, CsA enhances the late-phase progression after tumor adhesion through TGF-beta1 expression.
  • [MeSH-minor] Animals. Benzamides / pharmacology. Blotting, Western. Cell Adhesion. Cell Line, Tumor. Cell Movement / drug effects. Dioxoles / pharmacology. Disease Progression. Gene Expression Regulation, Neoplastic / drug effects. Killer Cells, Natural / drug effects. Killer Cells, Natural / pathology. Liver Neoplasms / genetics. Liver Neoplasms / immunology. Liver Neoplasms / secondary. Luminescence. Lymphatic Metastasis / immunology. Male. Neoplasm Metastasis / pathology. Rats. Rats, Inbred F344. Receptors, Chemokine / analysis. Receptors, Chemokine / genetics. Reperfusion Injury / pathology. Reverse Transcriptase Polymerase Chain Reaction. Transforming Growth Factor beta / analysis. Transforming Growth Factor beta / genetics. Transforming Growth Factor beta1

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  • (PMID = 16770245.001).
  • [ISSN] 0041-1337
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide; 0 / Benzamides; 0 / Dioxoles; 0 / Receptors, Chemokine; 0 / Tgfb1 protein, rat; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 83HN0GTJ6D / Cyclosporine
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56. Marshall JL: More fanfare for metastatic colon cancer resections. Gastrointest Cancer Res; 2007 Jan;1(1):28
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  • [Title] More fanfare for metastatic colon cancer resections.

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  • (PMID = 19262700.001).
  • [ISSN] 1934-7820
  • [Journal-full-title] Gastrointestinal cancer research : GCR
  • [ISO-abbreviation] Gastrointest Cancer Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2632518
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57. Ban D, Sakamoto Y, Shimada K, Kosuge T, Sekine S, Taniguchi H: Erythropoietin production caused by metastatic colon cancer. Int J Colorectal Dis; 2010 Mar;25(3):405
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  • [Title] Erythropoietin production caused by metastatic colon cancer.

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  • (PMID = 19756658.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 11096-26-7 / Erythropoietin
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58. Errante D, Bernardi D, Bianco A, Zanatta N, Salvagno L: Recurrence of exhausting hiccup in a patient treated with chemotherapy for metastatic colon cancer. Gut; 2005 Oct;54(10):1503-4
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  • [Title] Recurrence of exhausting hiccup in a patient treated with chemotherapy for metastatic colon cancer.

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  • (PMID = 16162960.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC1774708
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59. Hofmann LJ, Lee S, Waddell B, Davis KG: Effect of race on colon cancer treatment and outcomes in the Department of Defense healthcare system. Dis Colon Rectum; 2010 Jan;53(1):9-15
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  • [Title] Effect of race on colon cancer treatment and outcomes in the Department of Defense healthcare system.
  • PURPOSE: The increase in mortality noted in African Americans with colon cancer is attributed to advanced stage at presentation and disparities in treatment received.
  • The aim of this study was to assess the influence of race on the treatments and survival of colon cancer patients in an equal-access healthcare system.
  • METHODS: This retrospective cohort study included African American and white patients with colon cancer treated at Department of Defense facilities.
  • Disease stage, surgery performed, chemotherapy used, and overall survival were evaluated.
  • RESULTS: Of the 6958 colon cancer patients identified, 1115 were African American.
  • African Americans presented more frequently with stage IV disease, 23% vs 17% for whites (P < .001).
  • There was no difference in the use of systemic chemotherapy for stage III colon cancer (73.5% for African Americans vs 72.2% for whites; chi2, P > .05) or stage IV colon cancer (56.3% for African Americans vs 54.4% for whites; chi2, P > .05).
  • After adjusting for gender, age, tumor grade, and stage, African American race was not a risk factor for survival in Cox proportional hazard analysis (hazard ratio, 0.981; 95% confidence interval, 0.888-1.084).
  • African American patients undergo surgery and chemotherapy is administered at rates equal to whites for all stages of colon cancer.

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  • (PMID = 20010344.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Shao YY, Hong RL: Fatal thrombocytopenia after oxaliplatin-based chemotherapy. Anticancer Res; 2008 Sep-Oct;28(5B):3115-7
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  • A 64-year-old patient with metastatic colon cancer was admitted for his 24th course of chemotherapy with oxaliplatin and 24-hour infusion of fluorouracil and leucovorin.

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  • (PMID = 19031966.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; U3P01618RT / Fluorouracil
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61. Odoux C, Fohrer H, Hoppo T, Guzik L, Stolz DB, Lewis DW, Gollin SM, Gamblin TC, Geller DA, Lagasse E: A stochastic model for cancer stem cell origin in metastatic colon cancer. Cancer Res; 2008 Sep 1;68(17):6932-41
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  • [Title] A stochastic model for cancer stem cell origin in metastatic colon cancer.
  • Human cancers have been found to include transformed stem cells that may drive cancer progression to metastasis.
  • Here, we report that metastatic colon cancer contains clonally derived tumor cells with all of the critical properties expected of stem cells, including self-renewal and the ability to differentiate into mature colon cells.
  • Additionally, when injected into mice, these cells initiated tumors that closely resemble human cancer.
  • Karyotype analyses of parental and clonally derived tumor cells expressed many consistent (clonal) along with unique chromosomal aberrations, suggesting the presence of chromosomal instability in the cancer stem cells.
  • Thus, this new model for cancer origin and metastatic progression includes features of both the hierarchical model for cancerous stem cells and the stochastic model, driven by the observation of chromosomal instability.

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  • (PMID = 18757407.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCATS NIH HHS / TR / UL1 TR000005; United States / NIDCR NIH HHS / DE / R01 DE014729-05; None / None / / R01 DE014729-05; United States / NIDCR NIH HHS / DE / R01DE14729; United States / NIDCR NIH HHS / DE / R01 DE014729-04; United States / NCI NIH HHS / CA / CA047904-169019; United States / NCI NIH HHS / CA / P30 CA047904; United States / NCI NIH HHS / CA / CA047904-159019; United States / NCI NIH HHS / CA / P30CA047904; United States / NCI NIH HHS / CA / P30 CA047904-159019; United States / NIDCR NIH HHS / DE / R01 DE014729; United States / NCI NIH HHS / CA / P30 CA047904-169019; United States / NIDCR NIH HHS / DE / DE014729-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS57086; NLM/ PMC2562348
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62. Rengen MR, De J, Kott MM, Adler DG: Endoscopic ultrasound diagnosis of colon cancer metastatic to the pancreas. Endoscopy; 2006 Aug;38(8):853
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  • [Title] Endoscopic ultrasound diagnosis of colon cancer metastatic to the pancreas.

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  • (PMID = 16862530.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Xu F, Ye YJ, Cui ZR, Wang S: Allogeneic dendritomas induce anti-tumour immunity against metastatic colon cancer. Scand J Immunol; 2005 Apr;61(4):364-9
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  • [Title] Allogeneic dendritomas induce anti-tumour immunity against metastatic colon cancer.
  • Colon cancer (CC) is one of the most common malignancies in the Western world.
  • Although surgical resection is the first choice worldwide, at this point an effective approach for the treatment of patients with metastasis and cancer recurrence post-operation has not yet been found.
  • The aim of this study was to investigate the role of the allogeneic dendritomas from fusion of dendritic cells (DC) and metastatic CC cells in the activation of anti-tumour immunity against metastatic CC.
  • Dendritomas were generated by fused allogeneic human peripheral blood DC with metastatic CC cells using 50% polyethylene glycol.
  • These results demonstrate that allogeneic dendritomas activate T-cell responses against metastatic CC cells.
  • [MeSH-minor] Cell Fusion. Flow Cytometry. Humans. Immunophenotyping. Lymphocyte Activation. Neoplasm Metastasis. Polyethylene Glycols. T-Lymphocytes, Cytotoxic / cytology. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 15853920.001).
  • [ISSN] 0300-9475
  • [Journal-full-title] Scandinavian journal of immunology
  • [ISO-abbreviation] Scand. J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 30IQX730WE / Polyethylene Glycols
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64. Busić Z, Cupurdija K, Kolovrat M, Cavka V, Cavka M, Patrlj L, Servis D, Kvesić A: Isolated splenic metastasis from colon cancer--case report and literature review. Coll Antropol; 2010 Mar;34 Suppl 1:287-90
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  • [Title] Isolated splenic metastasis from colon cancer--case report and literature review.
  • In this paper we present a case of 70-year-old man with no history of previous diseases who was first operated under the diagnosis of acute abdomen revealing perforated colon tumor of splenic flexure with no metastases at that time.
  • Primary tumor was classified as Dukes (Astler-Coller)-C2, T4NIMO.
  • The latest follow up, a year after diagnosis of metastasis showed no signs of cancer disease.

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  • (PMID = 20402335.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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65. Matsuo Y, Sawai H, Ma J, Xu D, Ochi N, Yasuda A, Takahashi H, Funahashi H, Takeyama H: IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis. J Surg Oncol; 2009 May 1;99(6):361-7
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  • [Title] IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis.
  • BACKGROUND AND OBJECTIVES: Interleukin (IL)-1alpha plays an important role in colon cancer progression and angiogenesis.
  • We here asked whether IL-1alpha derived from cancer cells modulates vascular endothelial cell growth, migration and tubule formation.
  • METHODS: The existence of IL-1alpha mRNA and protein in colon cancer cell lines (WiDr, HT-29, Caco-2, COLO 320) were investigated with RT-PCR and ELISA.
  • RESULTS: IL-1alpha mRNA and protein were detected in highly metastatic colon cancer cells (WiDr and HT-29).
  • CONCLUSION: Based on these findings, we conclude that colon cancer cell-derived IL-1alpha up-regulates angiogenesis by modulating stromal cells within the tumor cells' microenvironment.
  • [MeSH-minor] Caco-2 Cells. Cell Line, Tumor. Cell Proliferation. Enzyme-Linked Immunosorbent Assay. Humans. Neoplasm Invasiveness. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19204921.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-1alpha; 0 / RNA, Messenger
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66. Kim ST, Lee J, Park SH, Park JO, Lim HY, Kang WK, Kim JY, Kim YH, Chang DK, Rhee PL, Kim DS, Yun H, Cho YB, Kim HC, Yun SH, Chun HK, Lee WY, Park YS: The effect of DNA mismatch repair (MMR) status on oxaliplatin-based first-line chemotherapy as in recurrent or metastatic colon cancer. Med Oncol; 2010 Dec;27(4):1277-85
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  • [Title] The effect of DNA mismatch repair (MMR) status on oxaliplatin-based first-line chemotherapy as in recurrent or metastatic colon cancer.
  • Colon cancer with DNA mismatch repair (MMR) defects reveals distinct clinical and pathologic features, including a better prognosis but reduced response to 5-fluorouracil (5-FU)-based chemotherapy.
  • A current standard treatment for recurrent or metastatic colon cancer uses capecitabine plus oxaliplatin (CAPOX), or continuous-infusion fluorouracil plus oxaliplatin (FOLFOX).
  • This study investigated the effect of MMR status on the treatment outcomes for CAPOX and FOLFOX as first-line combination chemotherapy in recurrent or metastatic colon cancer.
  • We analyzed 171 patients who had been treated with CAPOX or FOLFOX as first-line combination chemotherapy in recurrent or metastatic colon adenocarcinoma between February 2004 and July 2008.
  • The incidence of colon cancer with MMR defect was 10/171 (6%).
  • Colon cancers with MMR defect (MSI-H and/or MMR-D) are more commonly located in proximal to the splenic flexure (p=0.03).
  • The MMR status did not significantly influence the overall response (p=0.95) to first-line CAPOX or FOLFOX treatment in patients with recurrent or metastatic colon cancer.
  • According to the MMR status, there was no significant difference for PFS (p=0.50) and OS (p=0.47) in patients with recurrent or metastatic colon cancer treated with first-line CAPOX or FOLFOX.
  • In colon cancers with MMR defect, there was no significant difference for PFS (p=0.48) and OS (p=0.56) between CAPOX and FOLFOX as first-line combination chemotherapy.
  • The MMR status does not predict the effect of oxaliplatin-based combination chemotherapy as 1st line in recurrent or metastatic colon cancers.
  • CAPOX in the first-line treatment of recurrent or metastatic colon cancer with MMR intacts showed a superior OS compared with FOLFOX unlike colon cancer with MMR defects.
  • [MeSH-major] Adenocarcinoma / genetics. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colorectal Neoplasms / genetics. DNA Mismatch Repair / drug effects. Microsatellite Instability / drug effects. Neoplasm Recurrence, Local / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Capecitabine. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Female. Fluorouracil / administration & dosage. Fluorouracil / analogs & derivatives. Follow-Up Studies. Humans. Immunoenzyme Techniques. Infusions, Intravenous. Leucovorin / administration & dosage. Male. Middle Aged. Neoplasm Staging. Organoplatinum Compounds / administration & dosage. Polymerase Chain Reaction. Prognosis. Survival Rate. Young Adult

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  • (PMID = 19949897.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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67. Wakahara T, Tsukamoto T, Kitamura S, Watanabe A, Tsujimura T, Nakamura Y, Toyokawa A, Onishi N, Hamabe Y, Mukai H, Teramura K: Metastatic colon cancer from intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg; 2005;12(5):415-8
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  • [Title] Metastatic colon cancer from intrahepatic cholangiocarcinoma.
  • A 62-year-old man had been followed because of an elevated serum level of carcinoembryonic antigen without the detection of any cancer lesions.
  • However, there was a sudden increase in the serum level of carcinoembryonic antigen, and abdominal imagings showed a hepatic tumor with peripheral intrahepatic bile duct dilatation, and a submucosal tumor at the sigmoid colon with intact mucosa.
  • Histopathological findings showed that the hepatic tumor had perineural invasion, suggesting an intrahepatic cholangiocarcinoma, and that the colon tumor infiltrated the submucosa, while its mucosa was intact.
  • These findings suggested intrahepatic cholangiocarcinoma with metastatic sigmoid colon cancer.

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  • (PMID = 16258812.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 68238-35-7 / Keratins
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68. Hanna WC, Ponsky TA, Trachiotis GD, Knoll SM: Colon cancer metastatic to the lung and the thyroid gland. Arch Surg; 2006 Jan;141(1):93-6
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  • [Title] Colon cancer metastatic to the lung and the thyroid gland.
  • The clinical diagnosis of primary thyroid cancer is uncommon, constituting 1.5% of all cancers in the United States.
  • Clinically diagnosed metastatic cancer to the thyroid gland is rare.
  • Colon cancer is one of the most common cancers in the United States, with a high propensity to metastasize; 30% to 40% of patients have metastatic disease at the initial diagnosis.
  • The most common sites of metastasis from colon cancer are the regional lymph nodes, the liver, the lung, and the peritoneum.
  • Colon cancer metastasis to the thyroid gland is rare, with only a few reported cases, mainly in the pathology literature.
  • These cases describe metastasis from colon cancer to the thyroid gland that became apparent years after the initial diagnosis of colon cancer and were usually associated with dissemination to the liver, the lung, or both.
  • We report a case of colonic adenocarcinoma metastatic to the thyroid gland and lung without involvement of the liver.


69. Guzman L, Kozloff M, Wallace J, Starr A: Cutaneous eruption related to human epidermal growth factor receptor inhibitors in stage IV colon cancer. Clin J Oncol Nurs; 2009 Oct;13(5):491-3
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  • [Title] Cutaneous eruption related to human epidermal growth factor receptor inhibitors in stage IV colon cancer.

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  • (PMID = 19793706.001).
  • [ISSN] 1538-067X
  • [Journal-full-title] Clinical journal of oncology nursing
  • [ISO-abbreviation] Clin J Oncol Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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70. Czito BG, Bendell J, Willett CG: Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era? Oncology (Williston Park); 2006 Feb;20(2):179-87; discussion 187-8, 192
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  • [Title] Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era?
  • Colon cancer is a major public health problem.
  • For patients with early-stage disease, surgery results in excellent survival rates.
  • With the advent of novel and more effective systemic therapies for metastatic colon cancer, current and future clinical research will address the efficacy of these agents in the adjuvant setting.
  • Adjuvant radiation therapy should be considered in patients with colon cancer at high risk for local failure.

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  • (PMID = 16562650.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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71. Garibaldi DC, Adler RA: Cicatricial ectropion associated with treatment of metastatic colorectal cancer with cetuximab. Ophthal Plast Reconstr Surg; 2007 Jan-Feb;23(1):62-3
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  • [Title] Cicatricial ectropion associated with treatment of metastatic colorectal cancer with cetuximab.
  • Cetuximab is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR) of cancer cells expressing EGFR and prevents dimerization and downstream cell signaling pathways.
  • It has been shown to prolong survival in patients with metastatic colorectal cancer.
  • We present a 49-year-old man with metastatic colon cancer who had development of periocular skin toxicity, madarosis, and cicatricial ectropion after the addition of weekly cetuximab infusions to his baseline chemotherapy.

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  • (PMID = 17237696.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; PQX0D8J21J / Cetuximab
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72. Zenda T, Taniguchi K, Hashimoto T, Takeshita Y, Choto S, Masunaga T, Minato H: Metastatic colon cancer mimicking Crohn's disease. Ann Diagn Pathol; 2007 Dec;11(6):427-32
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  • [Title] Metastatic colon cancer mimicking Crohn's disease.
  • Although upper gastrointestinal endoscopy demonstrated signet-ring cell gastric carcinoma, colonoscopy and barium enema study yielded findings mimicking Crohn's disease in the colon, that is, skipping longitudinal ulcer scarlike strictures, cobblestone appearance, segmental stricture, and pseudosacculations.
  • After total gastrectomy and right-sided hemicolectomy, the final diagnosis of gastric cancer extensively involving the colon, and not of Crohn's disease complicating gastric cancer, was established.
  • Pathologic examination showed that anaplastic cancer with exuberant desmoplastic reaction and infiltration along the mesenteric border principally accounted for the morphological similarities noted between Crohn's disease and metastatic colon cancer in this case.
  • The findings in the present case, together with a review of the literature, suggest that metastatic colon cancer should be considered when Crohn-like colonic findings are encountered, not only in individuals with concurrent cancer in other sites but also in those with distant history of cancer.


73. Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V: Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. Biochim Biophys Acta; 2005 Jun 30;1741(1-2):215-23
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  • [Title] Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans.
  • ATB(0,+) (SLC6A14) is a Na(+)/Cl(-)-coupled arginine transporter expressed at low levels in normal colon.
  • Since arginine and arginine-derived nitric oxide (NO) play a critical role in cancer, we examined the expression of ATB(0,+) in colorectal cancer.
  • Paired normal and cancer tissues from colectomy specimens of 10 patients with colorectal cancer and from the liver tissue of one patient with hepatic metastasis from a colonic primary were used for the analysis of the levels of ATB(0,+) mRNA, inducible NOS (iNOS) mRNA and the corresponding proteins.
  • Tissues samples from the colon, liver, and lymph nodes of an additional patient with metastatic colon cancer were analyzed for ATB(0,+) protein alone.
  • The ATB(0,+) mRNA increased 22.9+/-3.0-fold in colorectal cancer compared to normal tissue and the increase was evident in each of the 10 cases examined. iNOS mRNA increased 5.2+/-1.1-fold in cancer specimens.
  • This study strongly suggests that the upregulation of ATB(0,+) may have a pathogenic role in colorectal cancer.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Metastasis / genetics. Nitric Oxide Synthase / analysis. Nitric Oxide Synthase / metabolism. Nitric Oxide Synthase Type II. RNA, Messenger / analysis. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15905073.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM 65344
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acid Transport Systems, Basic; 0 / RNA, Messenger; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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74. Seleye-Fubara D, Gbobo I: Pathological study of colorectal carcinoma in adult Nigerians: a study of 45 cases. Niger J Med; 2005 Apr-Jun;14(2):167-72
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  • The commonest site of this cancer is the rectum and the least occurred in the transverse colon.
  • Most of our patients presented with advanced cancer of stage IV & III of TNM classification (D and C of Astler-Coller System).
  • Patients present when the tumour is in an advanced stage hence poorer prognosis and the ages of the patents is about 10 years earlier than that of Caucasians.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Developing Countries. Female. Hospitals, Teaching. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Nigeria / epidemiology. Prognosis. Retrospective Studies

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  • (PMID = 16083240.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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75. Seemann H, Meran JG: [Meaningfullness and duration of palliative chemotherapy with regard to the quality of life of palliative patients]. Wien Med Wochenschr; 2010 Feb;160(3-4):64-69
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  • I am reporting on a 74-year-old female patient with primary pulmonary and hepatic metastatic colon cancer.
  • As a result of the extended anti-tumour therapy, remissions of the advanced cancer disease could be achieved repeatedly, which lead to a substantial increase of the patient's quality of life.
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Cooperative Behavior. Female. Humans. Interdisciplinary Communication. Neoplasm Staging. Patient Care Team. Radiotherapy, Adjuvant

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  • (PMID = 20300921.001).
  • [ISSN] 1563-258X
  • [Journal-full-title] Wiener medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Wien Med Wochenschr
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Austria
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76. Jaffe T, Schwartz B: Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer; 2008 Dec 1;123(11):2543-56
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  • [Title] Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways.
  • A direct and novel dose- and time-dependent activation of RhoA, Cdc42 and Rac1 by leptin is demonstrated in these aggressive colon cancer cells.
  • Our findings clearly indicate that leptin activates PI3K and Src kinase pathways in the metastatic colon cancer cells LS174T and HM7.
  • Understanding in-depth the pathways involved in leptin-associated enhanced cell locomotion and invasion may contribute with the design of novel therapeutics to treat obesity-associated advanced colorectal cancer.
  • [MeSH-minor] Cell Line, Tumor. Cell Movement / drug effects. Enzyme Activation / drug effects. Humans. Neoplasm Invasiveness. Phosphatidylinositol 3-Kinases / metabolism. Receptors, Leptin / metabolism. cdc42 GTP-Binding Protein / metabolism. rac1 GTP-Binding Protein / metabolism. rho GTP-Binding Proteins / metabolism

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18767036.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin; 0 / Receptors, Leptin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 3.6.5.2 / cdc42 GTP-Binding Protein; EC 3.6.5.2 / rac1 GTP-Binding Protein; EC 3.6.5.2 / rho GTP-Binding Proteins
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77. Murphy KC: Assessing software impact on clinical workflow and resource utilization. Stud Health Technol Inform; 2009;143:309-14
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  • The behaviours of two small groups, oncologists and pharmacists, were recorded and analyzed using a case study of patient with metastatic colon cancer.

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  • (PMID = 19380953.001).
  • [ISSN] 0926-9630
  • [Journal-full-title] Studies in health technology and informatics
  • [ISO-abbreviation] Stud Health Technol Inform
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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78. DeWitt JM: Endoscopic ultrasound-guided fine-needle aspiration of right adrenal masses: report of 2 cases. J Ultrasound Med; 2008 Feb;27(2):261-7
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  • The first patient had a history of colon cancer and was found to have a right adrenal mass during workup of jaundice.
  • The second patient also had a history of colon cancer and was found to have an enlarging right adrenal mass and a subcarinal mass during follow-up computed tomography.
  • Endoscopic ultrasound-guided FNA showed a pheochromocytoma in the first patient and metastatic colon cancer in the second patient.

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  • (PMID = 18204017.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Vickers MM, Easaw JC: Palmar-plantar hyperpigmentation with capecitabine in adjuvant colon cancer. J Gastrointest Cancer; 2008;39(1-4):141-3
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  • [Title] Palmar-plantar hyperpigmentation with capecitabine in adjuvant colon cancer.
  • BACKGROUND: Capecitabine (XELODA) is a chemotherapeutic agent used widely in the treatment of adjuvant/metastatic colon cancer and metastatic breast cancer.
  • CASE REPORT: Here, we describe three patients treated with adjuvant capecitabine for colon cancer (a 49-year-old East Indian man, a 58-year-old Asian woman, and a 54-year-old Aboriginal man) who developed moderate to severe HFS requiring delay and dose reduction.
  • Hyperpigmentation may also be more common in the non-Caucasian populations but more research is required to determine the ethnic distribution of this finding.

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  • [Cites] Actas Dermosifiliogr. 2007 Sep;98(7):491-3 [17669305.001]
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  • (PMID = 19440857.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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80. Polite BN, Dignam JJ, Olopade OI: Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites. Med Clin North Am; 2005 Jul;89(4):771-93
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  • [Title] Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites.
  • Certainly, issues surrounding screening for CRC remain important in understanding the advanced stage of presentation for African Americans.
  • Importantly, even if one were able to eliminate the differences in stage at presentation between African Americans and whites, a survival disadvantage, albeit a much smaller one, would likely persist.
  • This becomes even more important as the life-prolonging options for treating both localized and metastatic colon cancer continue to multiply.
  • Finally, the apparent greater disparity in outcome for African Americans who have stage II disease should be explored in more detail, because this could have an immediate impact on treatment recommendations.
  • For example, a 23-gene signature was recently found to be predictive of recurrence among patients with Dukes B colon cancer [66].


81. Rilling WS, Hohenwalter EJ: Combining local and regional therapeutic modalities to treat hepatic malignancies. Semin Intervent Radiol; 2006 Mar;23(1):33-8
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  • Hepatocellular carcinoma and metastatic colon cancer have proven to be challenging problems in oncology today.
  • Local ablation techniques along with intra-arterial therapy may be complementary and therefore increase survival in patients being treated for hepatocellular carcinoma and metastatic colon cancer.

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  • [Cites] J Vasc Interv Radiol. 2002 Dec;13(12):1225-32 [12471186.001]
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  • (PMID = 21326718.001).
  • [ISSN] 0739-9529
  • [Journal-full-title] Seminars in interventional radiology
  • [ISO-abbreviation] Semin Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3036303
  • [Keywords] NOTNLM ; Ablation / combined therapy / hepatocellular carcinoma
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82. Pencreach E, Guérin E, Nicolet C, Lelong-Rebel I, Voegeli AC, Oudet P, Larsen AK, Gaub MP, Guenot D: Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis. Clin Cancer Res; 2009 Feb 15;15(4):1297-307
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  • [Title] Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis.
  • PURPOSE: Despite recent progress, colon cancer is often resistant to combination chemotherapy, highlighting the need for development of novel therapeutic approaches.
  • We here investigated whether combination of rapamycin and irinotecan was active in human colon cancer models.
  • EXPERIMENTAL DESIGN: Human metastatic tumors were xenografted in nude mice and treated with low doses of irinotecan alone, rapamycin alone, or combination of both drugs.
  • The cellular effects of irinotecan and rapamycin were further characterized for HT-29 and HCT-116 colon cancer cells in vitro.
  • CONCLUSION: These results identify HIF-1alpha as a promising target and provide a rationale for clinical trials of low-dose irinotecan and rapamycin combination toward metastatic colon cancer.

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  • (PMID = 19190131.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Tumor Suppressor Protein p53; 7673326042 / irinotecan; EC 2.7.- / Protein Kinases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; W36ZG6FT64 / Sirolimus; XT3Z54Z28A / Camptothecin
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83. Uemura S, Maeda H, Munekage M, Yoshioka R, Okabayashi T, Hanazaki K: Hepatic resection for metastatic colon cancer in patients with situs inversus totalis complicated by multiple anomalies of the hepatobiliary system: the first case report. J Gastrointest Surg; 2009 Sep;13(9):1724-7
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  • [Title] Hepatic resection for metastatic colon cancer in patients with situs inversus totalis complicated by multiple anomalies of the hepatobiliary system: the first case report.
  • CASE: The patient was a 64-year-old man with situs inversus totalis who had previously undergone sigmoidectomy with regional lymphadenectomy for sigmoid colon cancer at age 62.
  • For the treatment of hepatic metastases from sigmoid colon cancer in a patient with situs inversus totalis, "left" hepatic lobectomy, partial hepatectomy, and radiofrequency ablation therapy were performed.
  • [MeSH-minor] Catheter Ablation / methods. Chemotherapy, Adjuvant. Colectomy / methods. Follow-Up Studies. Hepatectomy / methods. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Risk Assessment. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Ultrasonography, Doppler

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  • (PMID = 19415395.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Akman A, Yilmaz E, Mutlu H, Ozdogan M: Complete remission of psoriasis following bevacizumab therapy for colon cancer. Clin Exp Dermatol; 2009 Jul;34(5):e202-4
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  • [Title] Complete remission of psoriasis following bevacizumab therapy for colon cancer.
  • We describe a patient with metastatic colon cancer and psoriasis who experienced complete remission of psoriasis during treatment with bevacizumab and combination chemotherapy without any other treatment for psoriasis.

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  • (PMID = 19077094.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab
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85. Hegde SR, Sun W, Lynch JP: Systemic and targeted therapy for advanced colon cancer. Expert Rev Gastroenterol Hepatol; 2008 Feb;2(1):135-49
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  • [Title] Systemic and targeted therapy for advanced colon cancer.
  • Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related death in the USA.
  • Prognosis is best when the disease is detected early; however, nearly two-thirds of newly diagnosed cases of CRC have lymph node involvement or metastatic disease.
  • For years, 5-fluorouracil (FU)-based regimens represented the only viable treatment option for patients with metastatic CRC.
  • This review aims to discuss current systemic and targeted therapies for metastatic colon cancer with a focus on mechanism of action, indications, toxicity and efficacy.

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  • (PMID = 19072376.001).
  • [ISSN] 1747-4132
  • [Journal-full-title] Expert review of gastroenterology & hepatology
  • [ISO-abbreviation] Expert Rev Gastroenterol Hepatol
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK068366; United States / NIDDK NIH HHS / DK / DK068366; United States / NIDDK NIH HHS / DK / T32-DK00706
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents
  • [Number-of-references] 117
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86. Fichtner-Feigl S, Terabe M, Kitani A, Young CA, Fuss I, Geissler EK, Schlitt HJ, Berzofsky JA, Strober W: Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. Cancer Res; 2008 May 1;68(9):3467-75
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  • Here, we show that in two tumor models (the CT-26 metastatic colon cancer and the 15-12RM fibrosarcoma regressor models), this counter-surveillance mechanism requires the expression of a novel IL-13 receptor, IL-13R alpha(2), on Gr-1(intermediate) cells, because down-regulation of IL-13R alpha(2) expression or the activator protein-1 signal generated by the receptor via in vivo administration of specific small interfering RNA or decoy oligonucleotides leads to loss of TGF-beta(1) production.
  • Taking advantage of this latter fact, we then show in the CT-26 model that counter-immunosurveillance can be inhibited, anti-CT-26-specific CD8(+) cytolytic activity can be restored, and CT-26 metastatic tumor nodules can be greatly decreased by administration of TNF-alpha R-Fc.
  • These studies point to the prevention of metastatic cancer with an available agent with already known clinically acceptable adverse effects and toxicity.
  • [MeSH-minor] Animals. Cell Proliferation / drug effects. Down-Regulation. Drug Delivery Systems. Drug Evaluation, Preclinical. Female. Interleukin-13 / metabolism. Interleukin-13 / pharmacology. Lung Neoplasms / prevention & control. Lung Neoplasms / secondary. Mice. Mice, Inbred BALB C. Neoplasm Transplantation. Signal Transduction / drug effects. Survival Analysis. Transforming Growth Factor beta1 / metabolism. Tumor Cells, Cultured

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  • (PMID = 18451175.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 AI000432-23
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-13; 0 / Interleukin-13 Receptor alpha2 Subunit; 0 / RNA, Small Interfering; 0 / Transforming Growth Factor beta1
  • [Other-IDs] NLM/ NIHMS119905; NLM/ PMC2746996
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87. Zhang W, Jiang B, Guo Z, Sardet C, Zou B, Lam CS, Li J, He M, Lan HY, Pang R, Hung IF, Tan VP, Wang J, Wong BC: Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer. Carcinogenesis; 2010 Jul;31(7):1220-9
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  • [Title] Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer.
  • BACKGROUND AND AIMS: Cancer invasion and metastasis may associate with the phenotype transition called epithelial-mesenchymal transition (EMT).
  • We aim to evaluate the impact of four-and-a-half LIM protein 2 (FHL2) on EMT and invasion of colon cancer.
  • Mechanisms of FHL2 on expression or activity of E-cadherin and beta-catenin were assessed.
  • RESULTS: FHL2 was highly expressed in primary and metastatic colon cancer but not in normal tissues.
  • FHL2 was critical for cancer cell adhesion to extracellular matrix, migration and invasion.
  • Moreover, FHL2 acted as a potent EMT inducer by stimulating vimentin and matrix metalloproteinase-9 expressions and causing a loss of E-cadherin, whereas those alterations of EMT markers were not affected by silencing of Smad molecules (typical TGF-beta signal mediators) in FHL2 stable transfectant cells.
  • CONCLUSION: FHL2 is a potent EMT inducer and might be an important mediator for invasion and/or metastasis of colon cancer.
  • [MeSH-minor] Animals. Cadherins / analysis. Cell Adhesion. Cell Movement. HCT116 Cells. Humans. LIM-Homeodomain Proteins. Mice. Neoplasm Invasiveness. Neoplasm Metastasis. beta Catenin / metabolism

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  • (PMID = 20460358.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / FHL2 protein, human; 0 / Homeodomain Proteins; 0 / LIM-Homeodomain Proteins; 0 / Muscle Proteins; 0 / Transcription Factors; 0 / beta Catenin
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88. Derwinger K, Wettergren Y, Odin E, Carlsson G, Gustavsson B: A study of the MTHFR gene polymorphism C677T in colorectal cancer. Clin Colorectal Cancer; 2009 Jan;8(1):43-8
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  • [Title] A study of the MTHFR gene polymorphism C677T in colorectal cancer.
  • PURPOSE: The aim of this study was to examine the clinical significance of the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T in colorectal cancer (CRC).
  • The hypothesis was that the genotype could affect the risk of cancer development and the results of cancer treatment.
  • RESULTS: No genotype was associated with an increased risk of CRC or higher cancer stage.
  • In stage III colon cancer, the patients with CT/TT genotype had a poorer prognosis than those with the CC genotype.
  • Though the genotype-associated side effect risks remained in stage IV, the effect on survival was not significant (P < .1).
  • CONCLUSION: The MTHFR polymorphism C677T does, in our material, not affect the risk of CRC; however, it can affect the sensitivity to chemotherapy and the risk of side-effects and therefore survival in stage III and possibly stage IV colon cancer.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Female. Genotype. Humans. Male. Middle Aged. Neoplasm Staging. Polymorphism, Genetic. Prognosis. Proportional Hazards Models. Retrospective Studies. Statistics, Nonparametric. Survival Analysis

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  • (PMID = 19203896.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2)
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89. Sozen I, Small L, Kowalski M, Mayo SW, Hurwitz CA: Adenocarcinoma of the cervix metastatic from a colon primary and diagnosed from a routine pap smear in a 17-year-old woman: a case report. J Reprod Med; 2005 Oct;50(10):793-5
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  • [Title] Adenocarcinoma of the cervix metastatic from a colon primary and diagnosed from a routine pap smear in a 17-year-old woman: a case report.
  • BACKGROUND: Carcinoma metastatic to the uterine cervix is very rare.
  • The most frequent nongenital primary sites are the stomach and colon.
  • CONCLUSION: To our knowledge, this was the youngest patient in the literature with colon cancer metastatic to the cervix.


90. Díez-Fernández R, Salinas Hernández P, Girón-Duch C: [A review of chemotherapy for metastatic colon cancer]. Farm Hosp; 2006 Nov-Dec;30(6):359-69
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  • [Title] [A review of chemotherapy for metastatic colon cancer].
  • [Transliterated title] Revisión del tratamiento quimioterápico del cáncer de colon metastásico.
  • OBJECTIVE: To report and discuss the results of clinical trials published concerning chemotherapy for metastatic colorectal cancer in order to elucidate and define treatment guidelines.
  • CONCLUSIONS: New drugs for metastatic colorectal cancer open up new therapy lines allowing increasingly improved survival.

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  • (PMID = 17298193.001).
  • [ISSN] 1130-6343
  • [Journal-full-title] Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria
  • [ISO-abbreviation] Farm Hosp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 0 / Quinazolines; 0 / Thiophenes; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; 6804DJ8Z9U / Capecitabine; 7673326042 / irinotecan; FCB9EGG971 / raltitrexed; PQX0D8J21J / Cetuximab; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
  • [Number-of-references] 41
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91. Hanneken S, Kuerten V, Hoernke M, Neumann NJ: Metastatic colon cancer triggering an acute attack of variegate porphyria. Int J Colorectal Dis; 2009 Jan;24(1):127-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic colon cancer triggering an acute attack of variegate porphyria.


92. Huerta S, Li HC: Bevacizumab-associated hypertension: etiology, incidence, and management. Anticancer Drugs; 2009 May;20 Spec No 2:S22-4
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  • Bevacizumab (Avastin) is a recently developed monoclonal antibody, which targets the vascular endothelial growth factor signaling pathway, and is currently used in combination with cytotoxic agents as first-line or second-line therapy for patients with metastatic colon cancer.

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  • (PMID = 19352106.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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93. von Wichert G, Krndija D, Schmid H, von Wichert G, Haerter G, Adler G, Seufferlein T, Sheetz MP: Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines. Eur J Cell Biol; 2008 Jan;87(1):1-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines.
  • Here, we show that metastatic human colon cancer cell lines display altered matrix interaction.
  • Interaction of colon cancer cells with collagen I depends on integrins (mainly alpha(1)/beta(1)) but metastatic cells display delayed spreading and reduced extension of lamellipodia.
  • However, adhesion to pliable surfaces is ameliorated in metastatic variants.
  • In addition, consistent with defective strengthening of integrin-cytoskeleton linkages, metastatic cell lines show reduced random motility.
  • Taken together these data suggest that constitutive activation of FAK causes defects in spreading, reinforcement of integrin-cytoskeleton linkages and migration and at the same time could ameliorate the adhesion of metastatic cells to suboptimal surfaces.
  • [MeSH-minor] Cell Adhesion / drug effects. Cell Line, Tumor. Enzyme Activation / drug effects. Humans. Neoplasm Metastasis. RNA Interference. RNA, Small Interfering / pharmacology. Stress, Mechanical

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  • (PMID = 17904248.001).
  • [ISSN] 0171-9335
  • [Journal-full-title] European journal of cell biology
  • [ISO-abbreviation] Eur. J. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Integrin alpha1beta1; 0 / RNA, Small Interfering; EC 2.7.10.2 / Focal Adhesion Kinase 1; EC 2.7.10.2 / PTK2 protein, human
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94. Raftery L, Goldberg RM: Optimal delivery of cytotoxic chemotherapy for colon cancer. Cancer J; 2010 May-Jun;16(3):214-9
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  • [Title] Optimal delivery of cytotoxic chemotherapy for colon cancer.
  • Colon cancer is treated adjuvantly with 5-flourouracil (5-FU) and oxaliplatin, most commonly as part of the FOLFOX regimen, which has less toxicity than the older regimen FLOX (bolus 5-FU and oxaliplatin) that has fallen out of favor.
  • Patients with metastatic disease may be treated with a number of regimens, including FOLFOX and FOLFIRI; however, the environment is a not a monotonous vanilla and chocolate FOLFOX and FOLFIRI.
  • Cytotoxic agents, sequentially or in combination, are frequently combined with biologic agents to improve response in metastatic disease.
  • Clinical investigators have focused considerable attention on how best to apply all the agents active in metastatic colon cancer, a practice in evolution.
  • In this article, we highlight important, informative research regarding cytotoxic chemotherapy for colon cancer.

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  • (PMID = 20526099.001).
  • [ISSN] 1540-336X
  • [Journal-full-title] Cancer journal (Sudbury, Mass.)
  • [ISO-abbreviation] Cancer J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 48
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95. Arotçarena R, Calès V, Berthelémy P, Parent Y, Malet M, Etcharry F, Ferrari S, Pariente A: Severe sinusoidal lesions: a serious and overlooked complication of oxaliplatin-containing chemotherapy? Gastroenterol Clin Biol; 2006 Nov;30(11):1313-6
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  • The main toxicity of Oxaliplatin, a major drug in the treatment of metastatic colorectal carcinoma, is neurologic.
  • Four patients with metastatic colon cancer receiving oxaliplatin, 5 fluorouracil and elvorin, developped a progressive increase in gammaglutamyl transpeptidase and alkaline phosphatase, contrasting with tumour regression established by CT-scan and decrease in serum carcinoembryonic antigen concentrations.

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  • (PMID = 17185976.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin
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96. Ishizuka T, Yoshiyasu M, Yanagi K, Bando K, Yoshimura K, Tajiri T: [A patient with hepatic, pulmonary, and nodal metastases of colon cancer responding to CPT-11/TS-1 therapy]. Gan To Kagaku Ryoho; 2006 Jun;33(6):821-4
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  • [Title] [A patient with hepatic, pulmonary, and nodal metastases of colon cancer responding to CPT-11/TS-1 therapy].
  • In December 2002, a 67-year-old man underwent right colectomy (stage IIIa, cur B) for cancer of the ascending colon.
  • An increased CEA level was observed in July 2004, and metastasis of his colon cancer to the liver, lungs, and supraclavicular lymph nodes was confirmed.
  • There was a significant decrease of tumor markers and a decrease in the size of the metastatic tumors, with these findings being judged as PR.
  • CPT-11/TS-1 chemotherapy seems to be useful for maintaining the QOL of patients with metastatic colon cancer.

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  • (PMID = 16770105.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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97. Botchkina IL, Rowehl RA, Rivadeneira DE, Karpeh MS Jr, Crawford H, Dufour A, Ju J, Wang Y, Leyfman Y, Botchkina GI: Phenotypic subpopulations of metastatic colon cancer stem cells: genomic analysis. Cancer Genomics Proteomics; 2009 Jan-Feb;6(1):19-29
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  • [Title] Phenotypic subpopulations of metastatic colon cancer stem cells: genomic analysis.
  • BACKGROUND: Human cancer is characterized by high heterogeneity in gene expression, varieties of differentiation phenotypes and tumor-host interrelations.
  • Growing evidence suggests that tumor-initiating, or cancer stem cells (CSCs), may also represent a heterogeneous population.
  • The present study was undertaken to isolate and characterize the different phenotypic subpopulations of metastatic colon cancer and to develop a working colon CSC model for obtaining highly tumorigenic and clonogenic cells in sufficient numbers.
  • RESULTS: The metastatic colon cancer HCT116 cell line, which expressed a majority of known CSC markers, closely resembling the patterns of expression in exfoliated peritoneal cells from several metastatic colon cancer patients, was selected as a reference material.
  • Simultaneous analysis of 84 stem cell- and metastasis-related genes with corresponding PCR arrays identified genes differentially expressed in several colon CSC phenotypic populations versus bulk tumor cells, and in relation to each other.
  • Genomic analysis of several candidate CSC phenotypic populations may contribute to the identification of novel targets for colon cancer stem cell-targeted drug development and treatment.

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  • (PMID = 19451087.001).
  • [ISSN] 1109-6535
  • [Journal-full-title] Cancer genomics & proteomics
  • [ISO-abbreviation] Cancer Genomics Proteomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Peptides
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98. Ladino M, Guardiola VD, Paniagua M: Mirtazapine-induced hyponatremia in an elderly hospice patient. J Palliat Med; 2006 Apr;9(2):258-60
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  • CASE SUMMARY: A 72-year-old Latino male with stage IV colon cancer entered into hospice care and was treated for major depressive disorder with mirtazapine.

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  • (PMID = 16629552.001).
  • [ISSN] 1096-6218
  • [Journal-full-title] Journal of palliative medicine
  • [ISO-abbreviation] J Palliat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antidepressive Agents, Tricyclic; 250PJI13LM / Mianserin; A051Q2099Q / mirtazapine
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99. Gallagher DJ, Libby DM, Kemeny N: Elevated carcinoembryonic antigen and sarcoidosis masquerading as metastatic colon cancer. Clin Colorectal Cancer; 2009 Jul;8(3):172-4
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  • [Title] Elevated carcinoembryonic antigen and sarcoidosis masquerading as metastatic colon cancer.
  • When patients with colorectal cancer are monitored after resection of primary or metastatic disease, an elevated carcinoembryonic antigen (CEA) level is usually an indicator of recurrent disease.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Carcinoembryonic Antigen / blood. Colonic Neoplasms / radionuclide imaging. Neoplasm Recurrence, Local / radionuclide imaging. Sarcoidosis, Pulmonary / radionuclide imaging

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  • (PMID = 19632934.001).
  • [ISSN] 1938-0674
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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100. Iaria G, Anselmo A, De Luca L, Manuelli M, Lucchesi C, Tariciotti L, Monaco A, Sforza D, Nigro F, Abruzzese E, Tisone G: Conversion to rapamycin immunosuppression for malignancy after kidney transplantation: case reports. Transplant Proc; 2007 Jul-Aug;39(6):2036-7
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  • Rapamycin has been shown to limit the proliferation of a number of malignant cell lines in vivo and in vitro.
  • METHODS: Eight patients developed the following malignancies after kidney transplantation (mean 102.6 months; range 12 to 252): metastatic gastric cancer (n = 1), metastatic colon cancer (n = 1), bilateral nephrourothelioma (n = 1), skin cancer (n = 1), Kaposi's sarcoma (n = 2), posttransplant lymphoproliferative disorder (PTLD) (n = 2).
  • RESULTS: Both patients with metastatic cancer underwent chemotherapy and then succummbed after 6 and 13 months.
  • After a mean follow-up of 20.3 months (range 2 to 47), the remaining six patients are free from cancer disease.

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  • (PMID = 17692685.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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