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1. Bianchi C, Bianchi T: Susceptibility and resistance in the genesis of asbestos-related mesothelioma. Indian J Occup Environ Med; 2008 Aug;12(2):57-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Susceptibility and resistance in the genesis of asbestos-related mesothelioma.
  • Asbestos is the principal agent in the etiology of malignant mesothelioma.
  • However, a small proportion of people exposed to asbestos develop mesothelioma.
  • A genetic susceptibility is suggested by the occurrence of more mesothelioma cases among blood-related members of a single family.
  • This indicates a particular vulnerability to cancer in people with mesothelioma.
  • Not rarely, very old persons heavily exposed to asbestos remain free from asbestos-related cancer, a fact indicating an absolute resistance to the oncogenic effects of asbestos.
  • A relative resistance may be recognized in people severely exposed to asbestos who develop mesothelioma only after 60 years or more since the onset of the exposure.
  • The natural history of mesothelioma shows that a resistance to the oncogenic effects of asbestos does exist.
  • To strengthen the defence mechanisms may represent a way for preventing mesothelioma among people exposed to asbestos.

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  • (PMID = 20040979.001).
  • [ISSN] 1998-3670
  • [Journal-full-title] Indian journal of occupational and environmental medicine
  • [ISO-abbreviation] Indian J Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2796755
  • [Keywords] NOTNLM ; Asbestos / familial cancer / host factors / immune impairment / mesothelioma / resistance / susceptibility
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2. Terra Filho M, de Freitas JB, Nery LE: [Asbestos-related diseases]. J Bras Pneumol; 2006;32 Suppl 2:S48-53
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  • [Title] [Asbestos-related diseases].
  • This chapter presents a bibliographic review of asbestos-related diseases.
  • The latest diagnostic, radiological, computed tomography and lung function aspects of benign pleural disease, asbestosis, occupational lung cancer and mesothelioma are discussed.
  • [MeSH-major] Asbestos / toxicity. Occupational Diseases / etiology. Occupational Exposure / adverse effects

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  • (PMID = 17273598.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 29
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3. Kim HR: Overview of asbestos issues in Korea. J Korean Med Sci; 2009 Jun;24(3):363-7
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  • [Title] Overview of asbestos issues in Korea.
  • Asbestos is a carcinogen that causes diseases such as mesothelioma and lung cancer in humans.
  • There was a sharp increase in the use of asbestos in Korea in the 1970s as Korea's economy developed rapidly, and asbestos was only recently banned from use.
  • Despite the ban of its use, previously applied asbestos still causes many problems.
  • A series of asbestos-related events that recently occurred in Korea have caused the general public to become concerned about asbestos.
  • Therefore, it is necessary to take proper action to deal with asbestos-related events, such as mass outbreaks of mesothelioma among residents who lived near asbestos textile factories or asbestos mines.
  • Although there have been no rapid increases in asbestos-related illnesses in Korea to date, such illnesses are expected to increase greatly due to the amount of asbestos used and long latency period.
  • Decreasing the asbestos exposure level to levels as low as possible is the most important step in preventing asbestos-related illnesses in the next few decades.
  • However, there is a lack of specialized facilities for the analysis of asbestos and experts to diagnose and treat asbestos-related illnesses in Korea; therefore, national-level concern and support are required.
  • [MeSH-major] Asbestos / toxicity. Asbestosis / epidemiology. Lung Neoplasms / chemically induced. Mesothelioma / chemically induced

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  • (PMID = 19543418.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 22
  • [Other-IDs] NLM/ PMC2698178
  • [Keywords] NOTNLM ; Asbestos / Asbestosis / Korea / Lung Neoplasms / Mesothelioma
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4. Marinaccio A, Scarselli A, Binazzi A, Mastrantonio M, Ferrante P, Iavicoli S: Magnitude of asbestos-related lung cancer mortality in Italy. Br J Cancer; 2008 Jul 8;99(1):173-5
Hazardous Substances Data Bank. ASBESTOS .

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  • [Title] Magnitude of asbestos-related lung cancer mortality in Italy.
  • An ecological study, based on a data set containing all lung and pleural cancer deaths in each Italian municipality in the period 1980-2001, was performed.
  • The pleural to lung cancer ratio was estimated to be 1 : 1 and 3% (around 700) of all male lung cancer deaths were found to be asbestos-related.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / mortality. Occupational Exposure. Pleural Neoplasms / mortality

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  • (PMID = 18577986.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Other-IDs] NLM/ PMC2453024
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5. O'Reilly KM, Mclaughlin AM, Beckett WS, Sime PJ: Asbestos-related lung disease. Am Fam Physician; 2007 Mar 1;75(5):683-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asbestos-related lung disease.
  • The inhalation of asbestos fibers may lead to a number of respiratory diseases, including lung cancer, asbestosis, pleural plaques, benign pleural effusion, and malignant mesothelioma.
  • Patients with a history of significant asbestos exposure may warrant diagnostic testing and follow-up assessment, although it is unclear whether this improves outcomes.
  • Asbestosis generally progresses slowly, whereas malignant mesothelioma has an extremely poor prognosis.
  • The treatment of patients with asbestos exposure and lung cancer is identical to that of any patient with lung cancer.
  • Because exposure to cigarette smoke increases the risk of developing lung cancer in patients with a history of asbestos exposure, smoking cessation is essential.
  • Patients with asbestosis or lung cancer should receive influenza and pneumococcal vaccinations.
  • [MeSH-major] Asbestos / adverse effects. Carcinogens / toxicity. Lung Diseases / etiology. Occupational Diseases / etiology. Occupational Exposure / adverse effects

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  • [SummaryForPatientsIn] Am Fam Physician. 2007 Mar 1;75(5):690 [17375515.001]
  • (PMID = 17375514.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES01247
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 1332-21-4 / Asbestos
  • [Number-of-references] 18
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6. Otsuki T, Maeda M, Murakami S, Hayashi H, Miura Y, Kusaka M, Nakano T, Fukuoka K, Kishimoto T, Hyodoh F, Ueki A, Nishimura Y: Immunological effects of silica and asbestos. Cell Mol Immunol; 2007 Aug;4(4):261-8
Hazardous Substances Data Bank. ASBESTOS .

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  • [Title] Immunological effects of silica and asbestos.
  • Silicosis patients (SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders.
  • In addition, malignant complications such as lung cancer and malignant mesothelioma often occur in patients exposed to asbestos, and may be involved in the reduction of tumor immunity.
  • A brief summary of our investigations related to the immunological effects of silica/asbestos is presented.
  • Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica.
  • Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors, respectively.
  • In particular, as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan, efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety.
  • [MeSH-major] Asbestos / immunology. Silicon Dioxide / immunology

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  • (PMID = 17764616.001).
  • [ISSN] 1672-7681
  • [Journal-full-title] Cellular & molecular immunology
  • [ISO-abbreviation] Cell. Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Autoantibodies; 1332-21-4 / Asbestos; 7631-86-9 / Silicon Dioxide
  • [Number-of-references] 72
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7. Okio H, Kazu S, Masahiro M: Diagnostic biomarker of asbestos-related mesothelioma: example of translational research. Cancer Sci; 2007 Aug;98(8):1147-51
Hazardous Substances Data Bank. ASBESTOS .

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  • [Title] Diagnostic biomarker of asbestos-related mesothelioma: example of translational research.
  • Mesothelioma is an aggressive tumor arising from the mesothelium, and is usually associated with previous exposure to asbestos.
  • The incubation period of asbestos-related mesothelioma is estimated to be approximately 30-40 years.
  • Asbestos-related mesothelioma should be ascribed as a typical environmental carcinogen.
  • In this review, we will present asbestos-related mesothelioma for the study of problems in environmental carcinogenesis.
  • [MeSH-major] Asbestos / toxicity. Biomarkers, Tumor / analysis. Lung Neoplasms / etiology. Membrane Glycoproteins / analysis. Mesothelioma / chemically induced. Mesothelioma / etiology. Oncogene Proteins / analysis. Peritoneal Neoplasms / etiology. Pleural Neoplasms / etiology

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  • (PMID = 17532755.001).
  • [ISSN] 1347-9032
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Erc protein, human; 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / Oncogene Proteins; 0 / mesothelin; 1332-21-4 / Asbestos
  • [Number-of-references] 26
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8. Nolan RP, Ross M, Nord GL, Axten CW, Osleeb JP, Domnin SG, Price B, Wilson R: Risk assessment for asbestos-related cancer from the 9/11 attack on the World Trade Center. J Occup Environ Med; 2005 Aug;47(8):817-25
Hazardous Substances Data Bank. ASBESTOS .

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  • [Title] Risk assessment for asbestos-related cancer from the 9/11 attack on the World Trade Center.
  • OBJECTIVE: We sought to estimate the lifetime risk of asbestos-related cancer for residents of Lower Manhattan attributable to asbestos released into the air by the 9/11 attack on New York City's World Trade Center (WTC).
  • Cancer risk was assessed using an asbestos risk model that differentiates asbestos fiber-types and the US Environmental Protection Agency's model that does not differentiate fiber-types and combines mesothelioma and lung cancer risks.
  • RESULTS: The upper limit for the expected number of asbestos-related cancers is less than one case over the lifetime of the population for the risk model that is specific for fiber-types and 12 asbestos-related cancers with the US Environmental Protection Agency's model.
  • CONCLUSIONS: The cancer risk associated with asbestos exposures for residents of Lower Manhattan resulting from the collapse of the WTC is negligible.

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  • (PMID = 16093931.001).
  • [ISSN] 1076-2752
  • [Journal-full-title] Journal of occupational and environmental medicine
  • [ISO-abbreviation] J. Occup. Environ. Med.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Dust; 1332-21-4 / Asbestos
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9. Ameille J, Brochard P, Letourneux M, Paris C, Pairon JC: [Asbestos-related cancer risk in the presence of asbestosis or pleural plaques]. Rev Mal Respir; 2009 Apr;26(4):413-21; quiz 480, 483
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  • [Title] [Asbestos-related cancer risk in the presence of asbestosis or pleural plaques].
  • [Transliterated title] Risque de cancer lié à l'amiante en présence d'asbestose ou de plaques pleurales.
  • INTRODUCTION: The relationships between benign asbestos-related diseases (asbestosis and pleural plaques) and thoracic cancers are still debated.
  • STATE OF THE ART: Published studies show that there is a significant relationship between occupational exposure to asbestos and lung cancer risk, even in the absence of abnormalities consistent with asbestos exposure on postero-anterior chest x-ray.
  • In subjects with occupational exposure to asbestos, an increased risk of lung cancer and pleural mesothelioma is observed in subjects with pleural plaques on chest x-ray, in comparison with the general population.
  • In exposed subjects with similar cumulative exposure to asbestos, it is not demonstrated that pleural plaques are associated with an increased risk of lung cancer or pleural mesothelioma.
  • Their results must be confirmed by additional studies including a rigorous evaluation of the cumulative exposure to asbestos and chest CT-scans.
  • CONCLUSION: In the present state of knowledge, isolated pleural plaques do not justify specific medical surveillance, as compared to that required by the mere estimated cumulative exposure to asbestos.


10. Brauer C, Baandrup U, Jacobsen P, Krasnik M, Olsen JH, Pedersen JH, Rasmussen TR, Schlünssen V, Sherson D, Svolgaard B, Sørensen JB, Omland O: [Screening for asbestos-related conditions]. Ugeskr Laeger; 2009 Feb 2;171(6):433-6
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  • [Title] [Screening for asbestos-related conditions].
  • Screening programs for early detection of asbestos-related cancer have been considered.
  • Conventional X-ray, computed tomography of the thorax, and the biomarkers osteopontin and mesothelin have been critically reviewed in the literature, together with survival data from screening programs in asbestos-exposed populations.
  • Data do not currently support implementation of screening programs for asbestos-exposed persons in Denmark.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / etiology. Mesothelioma / etiology. Occupational Diseases / etiology


11. Bonde JP: [Occupational medicine--origins and perspectives]. Ugeskr Laeger; 2009 Feb 9;171(7):529-31
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  • Technological innovation and preventive measures have had a major impact on the occurrence of occupational disease in Denmark over the past 50 years, although some diseases such as asbestos-related cancer are still being diagnosed.

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  • (PMID = 19210938.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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12. Greenberg M: Estimating the number of asbestos-related cancer deaths in Great Britain. Ann Occup Hyg; 2006 Jan;50(1):107
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  • [Title] Estimating the number of asbestos-related cancer deaths in Great Britain.
  • [MeSH-major] Asbestos / toxicity. Lung Neoplasms / mortality. Occupational Diseases / mortality

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  • [CommentOn] Ann Occup Hyg. 2006 Jan;50(1):29-38 [16126764.001]
  • (PMID = 16371419.001).
  • [ISSN] 0003-4878
  • [Journal-full-title] The Annals of occupational hygiene
  • [ISO-abbreviation] Ann Occup Hyg
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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13. Gun R, Pratt NL, Roder DM, Ryan P: Asbestos-related cancers in refinery workers in the Australian petroleum industry. Arch Environ Occup Health; 2006 Jan-Feb;61(1):11-6
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  • [Title] Asbestos-related cancers in refinery workers in the Australian petroleum industry.
  • In this study of the incidence of asbestos-related cancer in the Australian petroleum industry, the authors traced a cohort of 16,543 petroleum industry workers for a total of 226,989 person-years.
  • The incidence of lung cancer was significantly lower than that in the general male population.
  • Lung cancer incidence was higher in maintenance workers than in nonmaintenance workers, but the excess was not statistically significant, as it was based on small numbers with wide confidence intervals.
  • Lung cancer rates in refinery workers did not increase with duration of employment; however, they did tend to be higher in workers hired in earlier decades.
  • Excess mesothelioma incidence in refinery workers is confirmed, but it is likely that there are few if any asbestos-related lung cancers.
  • [MeSH-major] Asbestos / adverse effects. Industry. Lung Neoplasms / epidemiology. Mesothelioma / epidemiology. Petroleum

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  • (PMID = 17503616.001).
  • [ISSN] 1933-8244
  • [Journal-full-title] Archives of environmental & occupational health
  • [ISO-abbreviation] Arch Environ Occup Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Petroleum; 1332-21-4 / Asbestos
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14. Brunner WM, Williams AN, Bender AP: Investigation of exposures to commercial asbestos in northeastern Minnesota iron miners who developed mesothelioma. Regul Toxicol Pharmacol; 2008 Oct;52(1 Suppl):S116-20
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  • [Title] Investigation of exposures to commercial asbestos in northeastern Minnesota iron miners who developed mesothelioma.
  • A 70% excess of mesothelioma, an asbestos-related cancer, has been reported among men in northeastern Minnesota, where iron mining has been the major industry.
  • The Minnesota Department of Health has studied iron miners who developed mesothelioma to identify possible sources of asbestos exposure.
  • The job histories of the cases were examined to determine if any of their jobs could have involved exposure to commercial asbestos.
  • Of the 15 for whom adequate work histories were available, 14 had identifiable sources of exposure to commercial asbestos in jobs held both inside and outside of the mining industry.
  • The time between employment in these asbestos-exposed occupations and the diagnosis of mesothelioma is consistent with the 20 or more year latency period that has been observed in other studies of this cancer.
  • [MeSH-major] Air Pollutants, Occupational / adverse effects. Asbestos / adverse effects. Asbestosis / etiology. Mesothelioma / etiology. Mining. Peritoneal Neoplasms / etiology. Pleural Neoplasms / etiology

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  • (PMID = 17988773.001).
  • [ISSN] 1096-0295
  • [Journal-full-title] Regulatory toxicology and pharmacology : RTP
  • [ISO-abbreviation] Regul. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 1332-21-4 / Asbestos
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15. Marier M, Charney W, Rousseau R, Lanthier R, van Raalte J: Exploratory sampling of asbestos in residences near Thetford Mines: the public health threat in Quebec. Int J Occup Environ Health; 2007 Oct-Dec;13(4):386-97
Hazardous Substances Data Bank. ASBESTOS .

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  • [Title] Exploratory sampling of asbestos in residences near Thetford Mines: the public health threat in Quebec.
  • In 2003-2004, the Asbestos Victims Association of Quebec undertook an exploratory sampling of the air and soil in the residential community of asbestos mining towns.
  • The risk of developing asbestos-related cancer following such in-home exposures over 30 years is estimated at 1 in 10,000.
  • [MeSH-major] Air Pollutants / analysis. Asbestos / analysis. Consumer Participation / methods. Environmental Exposure / analysis. Mining. Residence Characteristics

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  • (PMID = 18085052.001).
  • [ISSN] 1077-3525
  • [Journal-full-title] International journal of occupational and environmental health
  • [ISO-abbreviation] Int J Occup Environ Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Mineral Fibers; 0 / Soil Pollutants; 1332-21-4 / Asbestos
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16. Busacca S, Germano S, De Cecco L, Rinaldi M, Comoglio F, Favero F, Murer B, Mutti L, Pierotti M, Gaudino G: MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications. Am J Respir Cell Mol Biol; 2010 Mar;42(3):312-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications.
  • Human malignant mesothelioma is an asbestos-related cancer, with poor prognosis and low median survival.

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  • (PMID = 19502386.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MicroRNAs
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17. Moore S, Darlison L, Tod AM: Living with mesothelioma. A literature review. Eur J Cancer Care (Engl); 2010 Jul;19(4):458-68
MedlinePlus Health Information. consumer health - Mesothelioma.

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  • Mesothelioma is an asbestos-related cancer that affects mainly the pleura.
  • The findings suggest the impact of mesothelioma is multidimensional on: physical symptoms (especially pain, breathlessness, fatigue, cough, sleep disturbance, appetite loss and sweating), emotional functioning (anxiety, depression, fear and isolation), social consequences (changes in roles and relationships) and interventions (the necessity of frequent anti-cancer treatments and admissions for symptom control).

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  • (PMID = 19832887.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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18. Hida T, Ogawa S, Park J, Park J, Shimizu J, Horio Y, Yoshida K, Sekido Y: Chemosensitivity of newly established human malignant pleural mesothelioma cells: Significant growth inhibition by amrubicin, a novel 9-aminoanthracycline, or cyclooxygenase 2 inhibitor. J Clin Oncol; 2009 May 20;27(15_suppl):e19060

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  • [Title] Chemosensitivity of newly established human malignant pleural mesothelioma cells: Significant growth inhibition by amrubicin, a novel 9-aminoanthracycline, or cyclooxygenase 2 inhibitor.
  • : e19060 Background: Malignant pleural mesothelioma is asbestos-related malignancy that is highly resistant to current therapeutic modalities.
  • Survival of patients with malignant mesothelioma is very poor, especially in advanced stage, regardless of a recent advancement of chemotherapeutical modalities of combination with cisplatin and antifolate.
  • METHODS: Eleven cell lines derived from malignant mesothelioma were established in our laboratory.
  • RESULTS: Anti-cancer agents, cisplatin, vinorelbine, gemcitabine, gefitinib, or erlotinib, showed little growth inhibition, and pemetrexed and irinotecan showed modest growth inhibition in malignant mesothelioma cells, whereas amrubicin-13-OH showed strong growth inhibition.
  • Cyclooxygenase 2 inhibitors inhibit proliferation of malignant mesothelioma cells in a dose-dependent manner: modest growth inhibition at clinically achievable low concentrations and complete growth inhibition at clinically achievable high concentrations by intrapleural instillation.
  • CONCLUSIONS: Our study suggests that amrubicin can inhibit proliferation of malignant mesothelioma cells.
  • In addition, the use of a cyclooxygenase 2 inhibitor may be a promising therapeutic approach in the treatment of mesothelioma, because previous studies indicated the presence of increased cyclooxygenase 2 expression in malignant mesothelioma, which is notoriously resistant to chemotherapy.

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  • (PMID = 27962139.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Berman DW, Crump KS: A meta-analysis of asbestos-related cancer risk that addresses fiber size and mineral type. Crit Rev Toxicol; 2008;38 Suppl 1:49-73
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  • [Title] A meta-analysis of asbestos-related cancer risk that addresses fiber size and mineral type.
  • Quantitative estimates of the risk of lung cancer or mesothelioma in humans from asbestos exposure made by the U.S.
  • Environmental Protection Agency (EPA) make use of estimates of potency factors based on phase-contrast microscopy (PCM) and obtained from cohorts exposed to asbestos in different occupational environments.
  • Environmental Protection Agency (EPA) models for asbestos-related lung cancer and mesothelioma are expanded to allow the potency of fibers to depend upon their mineralogical types and sizes.
  • These category-specific potencies are estimated in a meta-analysis that fits the expanded models to potencies for lung cancer (KL's) or mesothelioma (KM's) based on PCM that were calculated for multiple epidemiological studies in our previous paper (Berman and Crump, 2008).
  • The fraction of total asbestos exposure in a given environment respectively represented by chrysotile and amphibole asbestos is also estimated from information in the literature for that environment.
  • Each such metric defined by width was composed of four categories of fibers: chrysotile or amphibole asbestos with lengths between 5 microm and 10 microm or longer than 10 microm.
  • Using these metrics three parameters were estimated for lung cancer and, separately, for mesothelioma: KLA, the potency of longer (length > 10 microm) amphibole fibers; rpc, the potency of pure chrysotile (uncontaminated by amphibole) relative to amphibole asbestos; and rps, the potency of shorter fibers (5 microm < length < 10 microm) relative to longer fibers.
  • For mesothelioma, the hypothesis that chrysotile and amphibole asbestos are equally potent (rpc = 1) was strongly rejected by every metric and the hypothesis that (pure) chrysotile is nonpotent for mesothelioma was not rejected by any metric.
  • Best estimates for the relative potency of chrysotile ranged from zero to about 1/200th that of amphibole asbestos (depending on metric).
  • For lung cancer, the hypothesis that chrysotile and amphibole asbestos are equally potent (rpc = 1) was rejected (p < or = .05) by the two metrics based on thin fibers (length < 0.4 microm and < 0.2 microm) but not by the metrics based on thicker fibers.
  • The "all widths" and widths < 0.4 microm metrics provide the best fits to both the lung cancer and mesothelioma data over the other metrics evaluated, although the improvements are only marginal for lung cancer.
  • That these two metrics provide equivalent (for mesothelioma) and nearly equivalent (for lung cancer) fits to the data suggests that the available data sets may not be sufficiently rich (in variation of exposure characteristics) to fully evaluate the effects of fiber width on potency.
  • Compared to the metric with widths > 0.2 microm with both rps and rpc fixed at 1 (which is nominally equivalent to the traditional PCM metric), the "all widths" and widths < 0.4 microm metrics provide substantially better fits for both lung cancer and, especially, mesothelioma.
  • Expansion of these metrics to include a category for fibers with lengths < 5 microm did not find any consistent evidence for any potency of these shortest fibers for either lung cancer or mesothelioma.
  • Unresolved in particular is the discrepancy in potency factors for lung cancer from Quebec chrysotile miners and workers at the Charleston, SC, textile mill, which mainly processed chrysotile from Quebec.
  • [MeSH-major] Asbestos, Amphibole / toxicity. Asbestos, Serpentine / toxicity. Carcinogens, Environmental / toxicity. Lung Neoplasms / chemically induced. Mesothelioma / chemically induced

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  • (PMID = 18686078.001).
  • [ISSN] 1547-6898
  • [Journal-full-title] Critical reviews in toxicology
  • [ISO-abbreviation] Crit. Rev. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Asbestos, Amphibole; 0 / Asbestos, Serpentine; 0 / Carcinogens, Environmental
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20. Burdett G, Bard D: Exposure of UK industrial plumbers to asbestos, Part I: Monitoring of exposure using personal passive samplers. Ann Occup Hyg; 2007 Mar;51(2):121-30
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  • [Title] Exposure of UK industrial plumbers to asbestos, Part I: Monitoring of exposure using personal passive samplers.
  • Epidemiological data suggest that there has been and may continue to be a significant risk to maintenance workers, who through their work may disturb asbestos-containing materials (ACM).
  • The asbestos exposure of industrial plumbers was measured using personal passive samplers developed at the Health and Safety Laboratory (HSL).
  • The light-weight samplers, which collect particles by electrostatic attraction, are simple to use and do not require prior knowledge that asbestos is to be disturbed as does conventional sampling.
  • The strategy was found to be a reasonably efficient and cost-effective way to obtain data on maintenance worker's exposure to asbestos.
  • The results of the TEM analysis of the passive samplers showed that the percentage of workers exposed to >5 microm long asbestos fibres was 62% in Round 1 and 58% in Round 2.
  • For phase contrast microscopy equivalent (PCME) asbestos fibres, the values were 46 and 29%, respectively.
  • The three samples with the highest numbers of fibres were followed up and were associated with plumbers working in areas which had supposedly been stripped of asbestos just prior to their starting work, suggesting that poor removal, clean-up and clearance practice presents a significant part of the risk to plumbers.
  • This gave an average exposure to regulated PCME fibres of 0.009 f ml-1 for amphibole asbestos and 0.049 f ml-1 for chrysotile.
  • If representative, the estimated lifetime risk of death from an asbestos related cancer for an exposure from age 20 for 40 years would be 68 per 100,000, which equates to an annual risk of death of the order of 10 per million.
  • [MeSH-major] Air Pollutants, Occupational / toxicity. Asbestos / toxicity. Carcinogens, Environmental / toxicity. Environmental Monitoring / instrumentation. Occupational Exposure / adverse effects
  • [MeSH-minor] Asbestos, Amphibole / analysis. Asbestos, Amphibole / toxicity. Asbestos, Serpentine / analysis. Asbestos, Serpentine / toxicity. Dust / analysis. Equipment Design. Great Britain. Hazardous Substances / analysis. Hazardous Substances / toxicity. Humans. Inhalation Exposure / adverse effects. Microscopy, Electron / methods. Microscopy, Phase-Contrast / methods. Particle Size. Population Surveillance / methods. Risk Assessment / methods

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  • (PMID = 17189281.001).
  • [ISSN] 0003-4878
  • [Journal-full-title] The Annals of occupational hygiene
  • [ISO-abbreviation] Ann Occup Hyg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Asbestos, Amphibole; 0 / Asbestos, Serpentine; 0 / Carcinogens, Environmental; 0 / Dust; 0 / Hazardous Substances; 1332-21-4 / Asbestos
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21. Wilson R, McConnell EE, Ross M, Axten CW, Nolan RP: Risk assessment due to environmental exposures to fibrous particulates associated with taconite ore. Regul Toxicol Pharmacol; 2008 Oct;52(1 Suppl):S232-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the early 1970s, it became a concern that exposure to the mineral fibers associated taconite ore processed in Silver Bay, Minnesota would cause asbestos-related disease including gastrointestinal cancer.
  • To further our understanding of the types of airborne fibers in Silver Bay we undertook a geological survey of their source the Peter Mitchell Pit, and found that there are no primary asbestos minerals at a detectable level.
  • However we identified two non-asbestos types of fibrous minerals in very limited geological locales.
  • We calculate the risk of asbestos-related mesothelioma and lung cancer using a variety of different pessimistic assumptions. (i) that all the non-asbestos fibers are as potent as asbestos fibers used in the EPA-IRIS listing for asbestos; with a calculated risk of asbestos-related cancer for environmental exposure at Silver Bay of 1 excess cancer in 28,500 lifetimes (or 35 excess cancers per 1,000,000 lifetimes) and secondly that taconite associated fibers are as potent as chrysotile the least potent form of asbestos.
  • The calculated risk is less than 0.77 excess cancer case in 1,000,000 lifetimes.
  • Finally, we briefly review the epidemiology studies of grunerite asbestos (amosite) focusing on the exposure conditions associated with increased risk of human mesothelioma.

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  • (PMID = 18207296.001).
  • [ISSN] 1096-0295
  • [Journal-full-title] Regulatory toxicology and pharmacology : RTP
  • [ISO-abbreviation] Regul. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Mineral Fibers; 0 / Particulate Matter; 0 / Silicates; 12249-26-2 / taconite; E1UOL152H7 / Iron
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22. Berman DW: Comparing milled fiber, Quebec ore, and textile factory dust: has another piece of the asbestos puzzle fallen into place? Crit Rev Toxicol; 2010;40(2):151-88
Hazardous Substances Data Bank. ASBESTOS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparing milled fiber, Quebec ore, and textile factory dust: has another piece of the asbestos puzzle fallen into place?
  • Given this performance, the MEM was also applied to address the disparity in lung cancer mortality per unit of exposure observed, respectively, among chrysotile miners/millers in Quebec and SC textile workers.
  • Moreover, phase-contrast microscopy (PCM) structures in Grade 3 dusts are 100% asbestos and counts of PCM-sized structures are identical, whether viewed by PCM or transmission electron microscope (TEM).
  • In contrast, a third of PCM structures in ore dusts are not asbestos and only a third that are counted by PCM are also counted by TEM.
  • Thus, the elutriator may be a valuable tool for reconstructing historical exposures suitable for supporting continued refinements of the risk models being developed to predict asbestos-related cancer risk.
  • [MeSH-major] Air Pollutants, Occupational / analysis. Asbestos / analysis. Dust / analysis. Environmental Exposure / analysis

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  • [CommentIn] Crit Rev Toxicol. 2010 Sep;40(8):749-51; author reply 752-7 [20722586.001]
  • (PMID = 20085481.001).
  • [ISSN] 1547-6898
  • [Journal-full-title] Critical reviews in toxicology
  • [ISO-abbreviation] Crit. Rev. Toxicol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Dust; 0 / Mineral Fibers; 1332-21-4 / Asbestos
  • [Number-of-references] 179
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23. Meirelles GS, Kavakama JI, Jasinowodolinski D, Nery LE, Terra-Filho M, Rodrigues RT, Neder JA, Bagatin E, D'ippolito G: [Asbestos-related pleuropulmonary diseases: pictorial essay]. Rev Port Pneumol; 2005 Sep-Oct;11(5):477-85
Hazardous Substances Data Bank. ASBESTOS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Asbestos-related pleuropulmonary diseases: pictorial essay].
  • [Transliterated title] Alterações pleurais e parenquimatosas relacionadas com a exposição ao asbestos: ensaio pictórico.
  • Pleural and pulmonary asbestos-related diseases range from benign conditions, like pleural effusion and pleural plaques, to some neoplasias, such as lung cancer and malignant mesothelioma.
  • Pleural effusion is the earliest finding after asbestos exposure, but the imaging findings are not specific.
  • Asbestosis is the pulmonary fibrosis due to asbestos.
  • Rounded atelectasis is a peripheral lung collapse in these individuals, generally related to pleural disease.
  • Some neoplasias, like lung carcinoma and pleural mesothelioma, are more prevalent in asbestos-exposed subjects.
  • The aim of this essay is to illustrate the main imaging findings of asbestos-related diseases.
  • [MeSH-major] Asbestos / adverse effects. Asbestosis / radiography. Pleural Diseases / etiology. Pleural Diseases / radiography

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  • (PMID = 16288346.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Portugal
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 38
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24. Hagemeyer O, Otten H, Kraus T: Asbestos consumption, asbestos exposure and asbestos-related occupational diseases in Germany. Int Arch Occup Environ Health; 2006 Sep;79(8):613-20
Hazardous Substances Data Bank. ASBESTOS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asbestos consumption, asbestos exposure and asbestos-related occupational diseases in Germany.
  • Like in most industrial countries, asbestos is a leading cause of occupational diseases, especially malignant diseases, in Germany.
  • Following the increased consumption of asbestos after World War I, the recognition of asbestos related diseases developed.
  • At the end of the 1930s, Germany was the first country to accept lung cancer in combination with asbestosis as an occupational disease and to initiate the endeavor for reduction of asbestos dust exposure.
  • Nevertheless after World War II the usage of asbestos increased dramatically.
  • The ban of asbestos first came into force in 1993.
  • Until this time several hundreds of thousands of workers had inhaled asbestos and the number of asbestos related diseases increased.
  • In this review the history and current status on asbestos consumption, asbestos exposure and asbestos related occupational diseases in Germany is presented.
  • [MeSH-major] Asbestos. Asbestosis / epidemiology. Lung Neoplasms / epidemiology. Occupational Exposure

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  • (PMID = 16523318.001).
  • [ISSN] 0340-0131
  • [Journal-full-title] International archives of occupational and environmental health
  • [ISO-abbreviation] Int Arch Occup Environ Health
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 48
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25. Lotti M: [Asbestos-related lung cancer]. G Ital Med Lav Ergon; 2010 Oct-Dec;32(4 Suppl):381-4
Hazardous Substances Data Bank. ASBESTOS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Asbestos-related lung cancer].
  • Lung cancer is the leading cause of tumour death and a large percentage of it is associated with tobacco smoking.
  • Epidemiology has shown that asbestos cumulative exposures increase the risk of lung cancer to a variable extent, depending on the manufacturing process and the specific job.
  • Clinical diagnosis of asbestos-related lung cancer is based upon medical history (exposures > 25 ff.ml years double the risk), possible lung fibrosis and counts of asbestos bodies and fibers in bronchoalveolar lavage and lung tissues.
  • Pleural plaques do not correlate with the cumulative exposures that are associated with lung cancer.
  • The multiplicative interaction between smoke and asbestos is only detectable when the risk associated with asbestos exposure is increased, i.e. after high exposures.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / etiology

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  • (PMID = 21438304.001).
  • [ISSN] 1592-7830
  • [Journal-full-title] Giornale italiano di medicina del lavoro ed ergonomia
  • [ISO-abbreviation] G Ital Med Lav Ergon
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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26. Kanceljak-Macan B: [Immunological aspects of asbestos-related diseases]. Arh Hig Rada Toksikol; 2009 Nov;60 Suppl:45-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Immunological aspects of asbestos-related diseases].
  • Asbestos is a generic name for a group of silicate minerals.
  • Exposure to asbestos may cause asbestos-related non-malignant diseases of the lung and pleura, including asbestosis, pleural plaques, diffuse pleural fibrosis, small airway disease, and malignant diseases such as lung cancer and malignant mesothelioma.
  • Inhaled asbestos fibres deposit in the distal regions of the respiratory system where they interact with epithelial cells and alveolar macrophages, and trigger active immunological response which leads to a slowly progressing lung fibrosis.
  • Asbestos may affect immunocompetent cells and induce malignant transformation of mesothelial cells.
  • It is still not clear whether asbestos causes mesothelioma directly or indirectly.
  • There is a general opinion that malignant mesothelioma is a complex tumour that results from the accumulation of multiple genetic alterations over many years.
  • There is no specific antibody for malignant mesothelioma as yet which could act as a single diagnostic tool.
  • Recent studies have demonstrated that asbestos acts on peripheral T cells as superantigen and that in malignant mesothelioma patients there is an overexpression of the Bcl-2 gene on peripheral CD4+ T cells.
  • These findings contribute to better understanding of biological effects of asbestos in respect to the duration and intensity of exposure.
  • [MeSH-major] Asbestos / immunology. Asbestosis / immunology. Mesothelioma / immunology. Pleural Neoplasms / immunology

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  • (PMID = 20853778.001).
  • [ISSN] 0004-1254
  • [Journal-full-title] Arhiv za higijenu rada i toksikologiju
  • [ISO-abbreviation] Arh Hig Rada Toksikol
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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27. Lotti M, Bergamo L, Murer B: Occupational toxicology of asbestos-related malignancies. Clin Toxicol (Phila); 2010 Jul;48(6):485-96
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  • [Title] Occupational toxicology of asbestos-related malignancies.
  • INTRODUCTION: Asbestos is banned in most Western countries but related malignancies are still of clinical concern because of their long latencies.
  • This review identifies and addresses some controversial occupational and clinical aspects of asbestos-related malignancies.
  • In addition, fibers and asbestos bodies are counted in lung tissue, broncho-alveolar lavage, and sputum, but different techniques and interlaboratory variability hamper the interpretation of reported measurements.
  • Several biomarkers have also been considered to screen individuals at risk for lung cancer and mesothelioma but reliable signatures are still missing.
  • ATTRIBUTION OF LUNG CANCER: Exposures correlating with lung cancer are high and in the same range where asbestosis occurs.
  • However, the unresolved question is whether the presence of fibrosis is a requirement for the attribution of lung cancer to asbestos.
  • The etiology of lung cancer is difficult to define in cases of low-level asbestos exposure and concurrent smoking habits.
  • MESOTHELIOMA: The diagnosis of malignant mesothelioma may also be difficult, because of procedures in sampling, fixation, and processing, and uses of immunohistochemical probes.
  • Quantitative analysis of asbestos body burden is better performed in digested lung tissues by counting asbestos bodies by light microscopy and/or uncoated fibers by transmission electron microscopy.
  • The benefits of screenings for asbestos-related malignancies are equivocal.
  • The attribution of lung cancer to asbestos exposure is difficult in a clinical setting because of the need to assess asbestos body burden and the fact that virtually all these patients are also tobacco smokers or former smokers.
  • Given the premise that asbestosis is necessary to causally link lung cancer to asbestos, it follows that the assessment of both lung fibrosis and asbestos body burden is necessary.
  • [MeSH-major] Asbestos / toxicity. Lung Neoplasms / chemically induced. Mesothelioma / chemically induced. Occupational Exposure / adverse effects

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  • (PMID = 20849338.001).
  • [ISSN] 1556-9519
  • [Journal-full-title] Clinical toxicology (Philadelphia, Pa.)
  • [ISO-abbreviation] Clin Toxicol (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 1332-21-4 / Asbestos
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28. Nymark P, Wikman H, Hienonen-Kempas T, Anttila S: Molecular and genetic changes in asbestos-related lung cancer. Cancer Lett; 2008 Jun 28;265(1):1-15
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  • [Title] Molecular and genetic changes in asbestos-related lung cancer.
  • Asbestos-exposure is associated with an increased risk of lung cancer, one of the leading causes of cancer deaths worldwide.
  • Asbestos is known to induce DNA and chromosomal damage as well as aberrations in signalling pathways, such as the MAPK and NF-kappaB cascades, crucial for cellular homeostasis.
  • This review describes the current knowledge on genomic and pathway aberrations characterizing asbestos-related lung cancer.
  • Specific asbestos-associated molecular signatures can assist the development of early biomarkers, molecular diagnosis, and molecular targeted treatments for asbestos-exposed lung cancer patients.
  • [MeSH-major] Asbestos / toxicity. Cell Transformation, Neoplastic / metabolism. Chromosome Aberrations / chemically induced. Lung Neoplasms / metabolism

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  • (PMID = 18364247.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Reactive Nitrogen Species; 0 / Reactive Oxygen Species; 1332-21-4 / Asbestos
  • [Number-of-references] 149
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29. Ak G, Metintas M, Metintas S, Erginel S, Alatas F, Yildirim H, Kurt E: Characteristics of lung cancer patients with asbestos-related radiological findings. Tuberk Toraks; 2008;56(3):257-65
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  • [Title] Characteristics of lung cancer patients with asbestos-related radiological findings.
  • The purpose of the current study was to compare the characteristics of lung cancer patients who had exposure to asbestos and asbestos-related radiological findings (ARRF) to the characteristics of patients who had no exposure.
  • Of the 766 lung cancer patients evaluated, 607 had no exposure to asbestos and no ARRF, 88 had ARRF and a history of exposure, remaining 71 patients had no exposure to asbestos occupationally and no ARRF, but we could not obtain environmental exposure history from them.
  • Lung cancer patients with ARRF were more often males, former smokers, and older than patients with no history of exposure to asbestos.
  • We suggest that specific attention should be given to the peripheral and lower zones of the lungs on CRX during the evaluation of the patients with ARRF for lung cancer.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / radiography. Occupational Exposure / adverse effects. Radiography, Thoracic / methods. Smoking / adverse effects
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Prognosis. Risk Factors. Sex Factors


30. Berman DW, Crump KS: Update of potency factors for asbestos-related lung cancer and mesothelioma. Crit Rev Toxicol; 2008;38 Suppl 1:1-47
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  • [Title] Update of potency factors for asbestos-related lung cancer and mesothelioma.
  • Environmental Protection Agency (EPA) health assessment document for asbestos (Nicholson, 1986, referred to as "the EPA 1986 update") is now 20 years old.
  • That document contains estimates of "potency factors" for asbestos in causing lung cancer (K(L)'s) and mesothelioma (K(M)'s) derived by fitting mathematical models to data from studies of occupational cohorts.
  • The EPA lung cancer model assumes that the relative risk varies linearly with cumulative exposure lagged 10 years.
  • Although the linear EPA model generally provided a good description of exposure response for lung cancer, in some cases it did so only by estimating a large background risk relative to the comparison population.
  • Lung cancer potency factors (K(L)'s) were developed from 20 studies from 18 locations, compared to 13 locations covered in the EPA 1986 update.
  • The K(M)'s showed evidence of a trend, with lowest K(M)'s obtained from cohorts exposed predominantly to chrysotile and highest K(M)'s from cohorts exposed only to amphibole asbestos, with K(M)'s from cohorts exposed to mixed fiber types being intermediate between the K(M)'s obtained from chrysotile and amphibole environments.
  • Despite the considerable uncertainty in the K(M) estimates, the K(M) from the Quebec mines and mills was clearly smaller than those from several cohorts exposed to amphibole asbestos or a mixture of amphibole asbestos and chrysotile.
  • For lung cancer, although there is some evidence of larger K(L)'s from amphibole asbestos exposure, there is a good deal of dispersion in the data, and one of the largest K(L)'s is from the South Carolina textile mill where exposures were almost exclusively to chrysotile.
  • Moreover, PCM does not distinguish between asbestos and nonasbestos particles.
  • In the accompanying article (Berman and Crump, 2008) the K(L)'s and K(M)'s and related uncertainty bounds obtained in this article are paired with fiber size distributions from the literature obtained using transmission electron microscopy (TEM).
  • The resulting database is used to define K(L)'s and K(M)'s that depend on both the size (e.g., length and width) and mineralogical type (e.g., chrysotile or crocidolite) of an asbestos structure.
  • [MeSH-major] Asbestos / toxicity. Carcinogens, Environmental / toxicity. Lung Neoplasms / chemically induced. Mesothelioma / chemically induced. Models, Biological. Occupational Diseases / chemically induced


31. Fazzo L, Nicita C, Cernigliaro A, Zona A, Bruno C, Fiumanò G, Villari C, Puglisi G, Marinaccio A, Comba P, Tumino R: [Mortality from asbestos-related causes and incidence of pleural mesothelioma among former asbestos cement workers in San Filippo del Mela (Sicily)]. Epidemiol Prev; 2010 May-Jun;34(3):87-92
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  • [Title] [Mortality from asbestos-related causes and incidence of pleural mesothelioma among former asbestos cement workers in San Filippo del Mela (Sicily)].
  • OBJECTIVES: The present paper estimates the burden of asbestos-related disease among asbestos-cement production workers of the Sacelit plant that operated in San Filippo del Mela (Province of Messina) from 1958 through 1993.
  • Standardised proportionate mortality (SPMR) for asbestos-related causes was computed for the years 1986-2009.
  • Proportionate mortality analysis among male subjects showed significant increases for pneumoconiosis (SPMR 80.1, 5 observed), lung cancer (SPMR 2.81, 10 observed) and pleural neoplasms (SPMR 19.4, 2 observed).
  • Also mortality from asbestos-related causes was in excess with respect to the regional reference population.
  • [MeSH-major] Asbestos / adverse effects. Asbestosis / epidemiology. Mesothelioma / epidemiology. Occupational Exposure / adverse effects. Pleural Neoplasms / epidemiology

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  • (PMID = 20852345.001).
  • [ISSN] 1120-9763
  • [Journal-full-title] Epidemiologia e prevenzione
  • [ISO-abbreviation] Epidemiol Prev
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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32. Darnton AJ, McElvenny DM, Hodgson JT: Estimating the number of asbestos-related lung cancer deaths in Great Britain from 1980 to 2000. Ann Occup Hyg; 2006 Jan;50(1):29-38
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  • [Title] Estimating the number of asbestos-related lung cancer deaths in Great Britain from 1980 to 2000.
  • INTRODUCTION: Inhalation of asbestos fibres is known to cause two main kinds of cancer-mesothelioma and lung cancer.
  • While the vast majority of mesothelioma cases are generally accepted as being caused by asbestos, the proportion of asbestos-related lung cancers is less clear and cannot be determined directly because cases are not clinically distinguishable from those due to other causes.
  • The aim of this study was to estimate the number of asbestos-related lung cancers among males by modelling their relative lung cancer mortality among occupations within Great Britain in terms of smoking habits, mesothelioma mortality (as an index of asbestos exposure) and occupation type (as a proxy for socio-economic factors).
  • METHODS: Proportional mortality ratios for lung cancer and mesothelioma for the 20-year period from 1980 to 2000 (excluding 1981) were calculated for occupational groups.
  • Poisson regression models were used to estimate the number of asbestos-related lung cancers by estimating the number of lung cancer deaths in each occupation assuming no asbestos exposure and subtracting this from the actual predicted number of lung cancer deaths.
  • RESULTS: The effect of asbestos exposure in predicting lung cancer mortality was weak in comparison to smoking habits and occupation type.
  • Our estimate of the number of asbestos-related lung cancers was between two-thirds and one death for every mesothelioma death: equivalent to between 11 500 and 16 500 deaths during the time period studied.
  • CONCLUSIONS: Asbestos-related lung cancer is likely to have accounted for 2-3% of all lung cancer deaths among males in Great Britain over the last two decades of the 20th century.
  • Asbestos-related lung cancers are likely to remain an important component of the total number of lung cancer deaths in the future as part of the legacy of past asbestos exposures in occupational settings.
  • [MeSH-major] Asbestos / toxicity. Lung Neoplasms / etiology. Lung Neoplasms / mortality. Occupational Exposure / adverse effects. Occupations


33. Antonescu-Turcu AL, Schapira RM: Parenchymal and airway diseases caused by asbestos. Curr Opin Pulm Med; 2010 Mar;16(2):155-61
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  • [Title] Parenchymal and airway diseases caused by asbestos.
  • PURPOSE OF REVIEW: The extensive industrial use of asbestos for many decades has been linked to development of benign and malignant pleuropulmonary disease.
  • This review summarizes newer evidence and ongoing controversies that exist in the literature regarding asbestos-related parenchymal and airway diseases.
  • RECENT FINDINGS: Asbestosis represents a significant respiratory problem despite the improvement in the workplace hygiene and a decrease in use of asbestos.
  • The role of asbestos exposure alone as a cause of chronic airway obstruction remains uncertain.
  • The relationship between lung cancer and asbestos exposure alone and in combination with smoking has also been investigated.
  • The benefit of screening for asbestos-related pleuropulmonary disease remains uncertain as does the use of computed tomography scanning for the purpose of screening.
  • SUMMARY: Future studies will help clarify the clinical issues and shape screening strategies for asbestos-exposed individuals.
  • [MeSH-major] Asbestos / adverse effects. Asbestosis / etiology. Lung Diseases / chemically induced

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  • (PMID = 20104177.001).
  • [ISSN] 1531-6971
  • [Journal-full-title] Current opinion in pulmonary medicine
  • [ISO-abbreviation] Curr Opin Pulm Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 34
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34. Thimpont J, Paquier L, Dumortier P, Farr P, De Brouwer C, Strauss P, De Vuyst P: [The missions of the Occupational Diseases Fund. Under-claim and recognition of occupational lung cancer, in particular those related to asbestos]. Rev Med Brux; 2009 Sep;30(4):318-25
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  • [Title] [The missions of the Occupational Diseases Fund. Under-claim and recognition of occupational lung cancer, in particular those related to asbestos].
  • The workers covered by this law are granted several rights, such as a financial compensation in case of temporary or permanent disability, a further compensation if they have to be taken away from the risk in the workplace, the reimbursement of health care costs related to the occupational disease, or the payment of an annuity to the widow(er) if death is its ultimate consequence.
  • Among the compensable diseases, we shall focus on lung cancer, and especially the one related to asbestos exposure.
  • This type of cancer is clearly under-registrated in Belgium as in most countries of the European Union, leading to an insufficient number of cases entitled to compensation by our institution.
  • In this instance, the insurance against occupational diseases and all related social advantages are hugely under-exploited in our country.
  • It is our duty to increase doctors' awareness of the problem and spread accurate information to reverse this trend and provide occupational cancer cases with a legitimate compensation, in particular those related to asbestos.
  • A wider knowledge of the occupational history of cancer patients, thanks to occupational physicians, and a better use of mineralogical analyses on lung samples, would improve this situation inacceptable on any level : medical, social or even human.
  • [MeSH-major] Asbestos / toxicity

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  • (PMID = 19899379.001).
  • [ISSN] 0035-3639
  • [Journal-full-title] Revue médicale de Bruxelles
  • [ISO-abbreviation] Rev Med Brux
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Carcinogens; 1332-21-4 / Asbestos
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35. Corhay JL, Duysinx B, Louis R: [Mesothelioma: a still current occupational cancer]. Rev Med Liege; 2008 Mar;63(3):128-35
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  • [Title] [Mesothelioma: a still current occupational cancer].
  • [Transliterated title] Le mésothéliome: un cancer professionnel encore d'actualité!
  • Mesothelioma is a rare tumour, particularly aggressive, whose incidence increases because of the massive use of asbestos during the last century.
  • Asbestos remains indeed the principal etiologic agent of this cancer.
  • The renewed interest with regard to this tumour is supported by the improvement of mesothelioma management, the new imaging techniques, the new treatments and the broad diffusion of information related to the risk of developing this tumour following asbestos inhalation.

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  • (PMID = 18561768.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 32
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36. Watterson A, Gorman T, Malcolm C, Robinson M, Beck M: The economic costs of health service treatments for asbestos-related mesothelioma deaths. Ann N Y Acad Sci; 2006 Sep;1076:871-81
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  • [Title] The economic costs of health service treatments for asbestos-related mesothelioma deaths.
  • This article explores the complex and neglected picture of occupational and environmental disease healthcare costs specifically relating to asbestos.
  • Data from UK sources on asbestos disease types recorded in 2000 and their disease treatment costs were obtained.
  • One hundred and twenty diagnosed, recorded, and treated cases of asbestos-related diseases occurred in 2000 in Scotland.
  • Many lung cancer cases due to asbestos exposure occur globally for each mesothelioma case.
  • Hence figures provided in this article are certain to be gross underestimates of the total health service and personal economic costs of asbestos illness and treatment in Scotland.
  • [MeSH-major] Asbestos / toxicity. Hospital Costs. Mesothelioma / therapy

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  • (PMID = 17119263.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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37. Rodríguez Portal JA, Rodríguez Becerra E, Rodríguez Rodríguez D, Alfageme Michavila I, Quero Martínez A, Diego Roza C, León Jiménez A, Isidro Montes I, Cebollero Rivas P: Serum levels of soluble mesothelin-related peptides in malignant and nonmalignant asbestos-related pleural disease: relation with past asbestos exposure. Cancer Epidemiol Biomarkers Prev; 2009 Feb;18(2):646-50
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  • [Title] Serum levels of soluble mesothelin-related peptides in malignant and nonmalignant asbestos-related pleural disease: relation with past asbestos exposure.
  • BACKGROUND: Malignant pleural mesothelioma (MPM) results from malignant transformation of mesothelial cells.
  • Past asbestos exposure represents a major risk factor for MPM and other benign pleural disease.
  • Soluble mesothelin-related peptides (SMRP) have been regarded as a promising serum biomarker for MPM.
  • The aim of this study was to investigate serum levels of SMRP in malignant and nonmalignant asbestos-related pleural disease.
  • PATIENTS: Four groups of patients were investigated: group 1 composed of 48 healthy subjects, group 2 composed of 177 patients with previous asbestos exposure and no pleural disease, group 3 composed of 36 patients with MPM, and group 4 composed of 101 patients with previous asbestos exposure and benign pleural disease.
  • Subjects exposed to asbestos had higher SMRP concentrations than normal control subjects regardless of the presence of pleural disease.
  • CONCLUSIONS: These data attest to good diagnostic sensitivity and specificity of SMRP for the diagnosis of malignant mesothelioma.
  • We have also shown that serum SMRP levels might serve as a marker of asbestos exposure.

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  • (PMID = 19190155.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin
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38. Kishimoto T, Gemba K, Fujimoto N, Onishi K, Usami I, Mizuhashi K, Kimura K: Clinical study of asbestos-related lung cancer in Japan with special reference to occupational history. Cancer Sci; 2010 May;101(5):1194-8
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  • [Title] Clinical study of asbestos-related lung cancer in Japan with special reference to occupational history.
  • A total of 152 patients with asbestos-related lung cancer recognized by the criteria of Japanese compensation law for asbestos-related diseases were examined and compared with 431 patients with non-asbestos-related lung cancer.
  • Almost all patients had occupational histories of asbestos exposure.
  • The median duration of asbestos exposure was 31 years and the median latency period was 47 years.
  • Regarding asbestos particles in the lung for 73 operated or autopsied patients, 62% had more than 5,000 particles per gram.
  • On the other hand, 100% of non-asbestos-related lung cancer patients had <5000 particles per gram with a median of 554 particles.
  • The number of asbestos bodies in the lung, male gender, absence of symptoms, smoking index, and early stage of cancer were significantly much more than those of non-asbestos-related lung cancer.
  • In this study, a diagnosis of asbestos-related lung cancer was made in 34% of patients by asbestosis, in 62% by presence of both pleural plaques and more than 10 years' occupational asbestos exposure, and in 4% by more than 5000 asbestos particles per gram of lung tissue.
  • Occupational histories, duration of asbestos exposure, and pleural plaques are common categories for the recognition of asbestos-related lung cancer in Japan.
  • [MeSH-major] Asbestos / toxicity. Lung Neoplasms / chemically induced. Occupational Exposure / adverse effects


39. Ahn YS, Kang SK: Asbestos-related occupational cancers compensated under the Industrial Accident Compensation Insurance in Korea. Ind Health; 2009 Apr;47(2):113-22
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  • [Title] Asbestos-related occupational cancers compensated under the Industrial Accident Compensation Insurance in Korea.
  • Compensation for asbestos-related cancers occurring in occupationally-exposed workers is a global issue; this is also an issue in Korea.
  • To provide basic information regarding compensation for workers exposed to asbestos, 60 cases of asbestos-related occupational lung cancer and mesothelioma that were compensated during 15 yr; from 1993 (the year the first case was compensated) to 2007 by the Korea Labor Welfare Corporation (KLWC) are described.
  • The KLWC approved compensation for 41 cases of lung cancer and 19 cases of mesothelioma.
  • The mean duration of asbestos exposure for lung cancer and mesothelioma cases was 19.2 and 16.0 yr, respectively.
  • The mean latency period for lung cancer and mesothelioma cases was 22.1 and 22.6 yr, respectively.
  • The major industries associated with mesothelioma cases were shipbuilding and maintenance (4 cases) and manufacture of asbestos textiles (3 cases).
  • The major industries associated with lung cancer cases were shipbuilding and maintenance (7 cases), construction (6 cases), and manufacture of basic metals (4 cases).
  • The statistics pertaining to asbestos-related occupational cancers in Korea differ from other developed countries in that more cases of mesothelioma were compensated than lung cancer cases.
  • Also, the mean latency period for disease onset was shorter than reported by existing epidemiologic studies; this discrepancy may be related to the short history of occupational asbestos use in Korea.
  • Considering the current Korean use of asbestos, the number of compensated cases in Korea is expected to increase in the future but not as much as developed countries.
  • [MeSH-major] Asbestos / toxicity. Asbestosis / epidemiology. Lung Neoplasms / epidemiology. Mesothelioma / epidemiology. Occupational Diseases / epidemiology. Occupational Exposure / analysis. Workers' Compensation / statistics & numerical data

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  • (PMID = 19367039.001).
  • [ISSN] 1880-8026
  • [Journal-full-title] Industrial health
  • [ISO-abbreviation] Ind Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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40. Reid A, de Klerk N, Ambrosini GL, Olsen N, Pang SC, Berry G, Musk AW: The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos alone. Occup Environ Med; 2005 Dec;62(12):885-9
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  • [Title] The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos alone.
  • AIMS: To determine if the presence of asbestosis is a prerequisite for lung cancer in subjects with known exposure to blue asbestos (crocidolite).
  • METHODS: Former workers and residents of Wittenoom with known amounts of asbestos exposure (duration, intensity, and time since first exposure), current chest x ray and smoking information, participating in a cancer prevention programme (n = 1988) were studied.
  • The first plain chest radiograph taken at the time of recruitment into the cancer prevention programme was examined for radiographic evidence of asbestosis according to the UICC (ILO) classification.
  • Cox proportional hazards modelling was used to relate asbestosis, asbestos exposure, and lung cancer.
  • RESULTS: Between 1990 and 2002 there were 58 cases of lung cancer.
  • Smoking status was the strongest predictor of lung cancer, with current smokers (OR = 26.5, 95% CI 3.5 to 198) having the greatest risk.
  • Radiographic asbestosis (OR = 1.94, 95% CI 1.09 to 3.46) and asbestos exposure (OR = 1.21 per f/ml-year, 95% CI 1.02 to 1.42) were significantly associated with an increased risk of lung cancer.
  • There was an increased risk of lung cancer with increasing exposure in those without asbestosis.
  • CONCLUSION: In this cohort of former workers and residents of Wittenoom, asbestosis is not a mandatory precursor for asbestos related lung cancer.
  • These findings support the hypothesis that it is the asbestos fibres per se that cause lung cancer, which can develop with or without the presence of asbestosis.
  • [MeSH-major] Asbestos, Crocidolite. Asbestosis / complications. Lung Neoplasms / etiology. Occupational Exposure

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  • (PMID = 16299098.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 12001-28-4 / Asbestos, Crocidolite
  • [Other-IDs] NLM/ PMC1740938
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41. Verger P, Arnaud S, Ferrer S, Iarmarcovai G, Saliba ML, Viau A, Souville M: Inequities in reporting asbestos-related lung cancer: influence of smoking stigma and physician's specialty, workload and role perception. Occup Environ Med; 2008 Jun;65(6):392-7
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  • [Title] Inequities in reporting asbestos-related lung cancer: influence of smoking stigma and physician's specialty, workload and role perception.
  • OBJECTIVES: To study physician barriers to workers' compensation claims for asbestos-related cancers, focusing on smokers' stigma and physicians' speciality and role perception.
  • Standardised questionnaires explored their behaviour, attitudes and practices in the field of occupational health and their responses to a case vignette of a lung cancer patient with long-term occupational asbestos exposure.
  • [MeSH-major] Asbestos / toxicity. Attitude of Health Personnel. Lung Neoplasms / etiology. Occupational Diseases / etiology. Smoking / psychology. Workers' Compensation


42. Strand LA, Martinsen JI, Koefoed VF, Sommerfelt-Pettersen J, Grimsrud TK: Asbestos-related cancers among 28,300 military servicemen in the Royal Norwegian Navy. Am J Ind Med; 2010 Jan;53(1):64-71
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  • [Title] Asbestos-related cancers among 28,300 military servicemen in the Royal Norwegian Navy.
  • INTRODUCTION: This study focus on the incidence of asbestos-related cancers among 28,300 officers and enlisted servicemen in the Royal Norwegian Navy.
  • Until 1987, asbestos aboard the vessels potentially caused exposure to 11,500 crew members.
  • METHODS: Standardized incidence ratios (SIR) were calculated for malignant mesothelioma, lung cancer, and laryngeal, pharyngeal, stomach, and colorectal cancers according to service aboard between 1950 and 1987 and in other Navy personnel.
  • Lung cancer was nearly 20% higher than expected among both engine crews and non-engine crews.
  • An excess of colorectal cancer bordering on statistical significance was seen among non-engine crews (SIR = 1.14; 95% CI = 0.98-1.32).
  • Land-based personnel and personnel who served aboard after 1987 had lower lung cancer incidence than expected (SIR = 0.77; 95% CI = 0.64-0.92).
  • The mesothelioma incidence can be taken as an indicator of the presence or absence of asbestos exposure, but it offered no consistent explanation to the variation in incidence of other asbestos-related cancers.
  • [MeSH-major] Asbestos / adverse effects. Asbestosis / epidemiology. Military Personnel / statistics & numerical data. Naval Medicine / statistics & numerical data. Neoplasms / epidemiology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19921706.001).
  • [ISSN] 1097-0274
  • [Journal-full-title] American journal of industrial medicine
  • [ISO-abbreviation] Am. J. Ind. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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43. Nymark P, Wikman H, Ruosaari S, Hollmén J, Vanhala E, Karjalainen A, Anttila S, Knuutila S: Identification of specific gene copy number changes in asbestos-related lung cancer. Cancer Res; 2006 Jun 1;66(11):5737-43
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  • [Title] Identification of specific gene copy number changes in asbestos-related lung cancer.
  • Asbestos is a well-known lung cancer-causing mineral fiber.
  • In vitro and in vivo experiments have shown that asbestos can cause chromosomal damage and aberrations.
  • To investigate whether a distinct chromosomal aberration profile could be detected in the lung tumors of heavily asbestos-exposed patients, we analyzed the copy number profiles of 14 lung tumors from highly asbestos-exposed patients and 14 matched tumors from nonexposed patients using classic comparative genomic hybridization (CGH).
  • Classic CGH showed, on average, more aberrations in asbestos-exposed than in nonexposed patients, and an altered region in chromosome 2 seemed to occur more frequently in the asbestos-exposed patients.
  • Furthermore, 11 fragile sites coincided with the 18 asbestos-associated regions (P = 0.08), which may imply preferentially caused DNA damage at these sites.
  • Our findings are the first evidence, indicating that asbestos exposure may produce a specific DNA damage profile.
  • [MeSH-major] Asbestos / adverse effects. Chromosome Aberrations / chemically induced. Lung Neoplasms / etiology. Lung Neoplasms / genetics

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  • (PMID = 16740712.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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44. Murakami S, Nishimura Y, Maeda M, Kumagai N, Hayashi H, Chen Y, Kusaka M, Kishimoto T, Otsuki T: Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. Environ Health Prev Med; 2009 Jul;14(4):216-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases.
  • This review is partly composed of the presentation "Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases" delivered during the symposium "Biological effects of fibrous and particulate substances and related areas" organized by the Study Group of Fibrous and Particulate Studies of the Japanese Society of Hygiene and held at the 78th Annual Meeting in Kumamoto, Japan.
  • In this review, we briefly introduce the results of recent immunological analysis using the plasma of silica and asbestos-exposed patients diagnosed with silicosis, pleural plaque, or malignant mesothelioma.
  • Thereafter, experimental background and speculation concerning the immunological pathophysiology of silica and asbestos-exposed patients are discussed.

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  • (PMID = 19568841.001).
  • [ISSN] 1342-078X
  • [Journal-full-title] Environmental health and preventive medicine
  • [ISO-abbreviation] Environ Health Prev Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2711881
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45. Everatt RP, Smolianskiene G, Tossavainen A, Cicenas S, Jankauskas R: Occupational asbestos exposure among respiratory cancer patients in Lithuania. Am J Ind Med; 2007 Jun;50(6):455-63
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  • [Title] Occupational asbestos exposure among respiratory cancer patients in Lithuania.
  • BACKGROUND: Despite intensive use of asbestos, no cancer case has ever been diagnosed as asbestos related in Lithuania.
  • This paper attempts to estimate the proportion of those occupationally exposed to asbestos among respiratory cancer patients.
  • MATERIAL AND METHODS: Occupational exposure to asbestos was assessed retrospectively for 298 lung cancer and four mesothelioma patients, admitted to the Institute of Oncology, Vilnius.
  • The evaluation was based on personal interview data using an internationally established questionnaire covering most likely activities of asbestos exposure at the workplace.
  • Cumulative exposure to asbestos at work was estimated in fiber years.
  • Lung tissue asbestos fiber burden analysis was conducted by scanning transmission electron microscopy on 23 samples.
  • RESULTS: A cumulative asbestos exposure of > or =25 fiber years was found for 10 lung cancer patients (3.4%).
  • They worked in foundries, construction, installation, shipyard, power plant, railway, asbestos cement, glass and chemical industry.
  • In a further 56 lung cancer patients (18.8%) and for one (25%) mesothelioma patient, a cumulative exposure from 5 to 24.9 fiber years was assessed.
  • Asbestos fibers were detected in 18 cases, the burden ranged from 0.1 to 4.1 million fibers/g dry lung tissue; concentrations exceeding 1 million f/g dry lung tissue were found in four cases.
  • CONCLUSIONS: Findings indicate that a fraction (3.4%) of the lung cancer cases could be attributed to heavy occupational exposure to asbestos using the Helsinki criterion of > or =25 fiber years.
  • Therefore, approximately 50 lung cancer cases per year in Lithuania could be asbestos-related compensable occupational diseases.
  • [MeSH-major] Asbestos, Serpentine. Asbestosis / epidemiology. Lung Neoplasms / epidemiology. Mesothelioma / epidemiology. Pleural Neoplasms / epidemiology

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  • (PMID = 17497698.001).
  • [ISSN] 0271-3586
  • [Journal-full-title] American journal of industrial medicine
  • [ISO-abbreviation] Am. J. Ind. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Asbestos, Serpentine
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46. Wright CM, Larsen JE, Hayward NK, Martins MU, Tan ME, Davidson MR, Savarimuthu SM, McLachlan RE, Passmore LH, Windsor MN, Clarke BE, Duhig EE, Yang IA, Bowman RV, Fong KM: ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas. Genes Chromosomes Cancer; 2010 Aug;49(8):688-98
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  • [Title] ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas.
  • Asbestos-related lung cancer accounts for 4-12% of all lung cancers worldwide.
  • Since putative mechanisms of carcinogenesis differ between asbestos and tobacco induced lung cancers, tumors induced by the two agents may be genetically distinct.
  • To identify gene expression biomarkers associated with asbestos-related lung tumorigenicity we performed gene expression array analysis on tumors of 36 patients with primary lung adenocarcinoma, comparing 12 patients with lung asbestos body counts above levels associated with urban dwelling (ARLC-AC: asbestos-related lung cancer-adenocarcinoma) with 24 patients with no asbestos bodies (NARLC-AC: non-asbestos related lung cancer-adenocarcinoma).
  • Further studies are being designed to investigate the possible role of this gene in asbestos lung tumorigenicity, its potential utility as a marker of asbestos related lung cancer for purposes of causal attribution, and its potential as a treatment target for lung cancers arising in asbestos exposed persons.
  • [MeSH-major] ADAM Proteins / genetics. Adenocarcinoma / chemically induced. Asbestos / adverse effects. Carcinogens. Lung Neoplasms / chemically induced

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  • (PMID = 20544843.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinogens; 0 / RNA, Messenger; 1332-21-4 / Asbestos; EC 3.4.24.- / ADAM Proteins; EC 3.4.24.- / ADAM28 protein, human
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47. Fry C: An investigation into asbestos related disease in the dental industry. Br Dent J; 2009 May 23;206(10):515-6
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  • [Title] An investigation into asbestos related disease in the dental industry.
  • This article discusses the dangers of the asbestos-based disease mesothelioma and the possible origins of this form of cancer in dental professionals.
  • [MeSH-major] Asbestos / adverse effects. Mesothelioma / etiology. Occupational Diseases / etiology. Occupational Exposure / adverse effects

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  • [CommentIn] Br Dent J. 2009 May 23;206(10):512 [19461608.001]
  • (PMID = 19461615.001).
  • [ISSN] 1476-5373
  • [Journal-full-title] British dental journal
  • [ISO-abbreviation] Br Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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48. Bianchi C, Bianchi T: Malignant mesothelioma: global incidence and relationship with asbestos. Ind Health; 2007 Jun;45(3):379-87
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  • [Title] Malignant mesothelioma: global incidence and relationship with asbestos.
  • A lot of data indicate a relationship between mesothelioma and asbestos.
  • The hot areas for mesothelioma exactly correspond to the sites of industries with high asbestos use, such as shipbuilding and asbestos-cement industry.
  • However, in many countries with high asbestos consumption, mesothelioma incidence is low.
  • The latency periods elapsing between first exposure to asbestos and development of mesothelioma are mostly longer than 40 yr.
  • An inverse relationship exists between intensity of asbestos exposure and length of the latency period.
  • Mesothelioma generally develops after long-time exposures to asbestos.
  • Possible co-factors in the pathogenesis of asbestos-related mesothelioma include genetic predisposition, diets poor in fruit and vegetables, viruses, immune impairment, recurrent serosal inflammation.
  • [MeSH-major] Asbestos / toxicity. Developed Countries / statistics & numerical data. Environmental Exposure / adverse effects. Global Health. Mesothelioma / epidemiology


49. Park EK, Hannaford-Turner KM, Hyland RA, Johnson AR, Yates DH: Asbestos-related occupational lung diseases in NSW, Australia and potential exposure of the general population. Ind Health; 2008 Dec;46(6):535-40
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  • [Title] Asbestos-related occupational lung diseases in NSW, Australia and potential exposure of the general population.
  • Asbestos is a fibrous silicate which is recognized as causing a variety of lung disorders including malignant mesothelioma of the pleura, lung cancer and asbestosis.
  • Asbestos use has been banned in most developed countries but exposure still occurs under strict regulation in occupational settings and also occasionally in domestic settings.
  • Although the hazards of asbestos are well known in developed countries, awareness of its adverse health effects is less in other parts of the world, particularly when exposure occurs in non-occupational settings.
  • Experience of asbestos use and its adverse heath effects in developed countries such as Australia have resulted in development of expertise in the diagnosis and treatment of asbestos-related diseases as well as in screening and this can be used to help developing countries facing the issue of asbestos exposure.
  • [MeSH-major] Asbestos / adverse effects. Lung Diseases. Occupational Exposure. Public Health

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  • (PMID = 19088405.001).
  • [ISSN] 1880-8026
  • [Journal-full-title] Industrial health
  • [ISO-abbreviation] Ind Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 43
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50. Lee KH, Yoon HS, Choi SJ, Kang D: Asbestos exposure and malignant mesothelioma in Korea. Asian Pac J Cancer Prev; 2009 Oct-Dec;10(4):707-10
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  • [Title] Asbestos exposure and malignant mesothelioma in Korea.
  • Although importation of asbestos to Korea has decreased, there are growing concerns of its hazardous effects.
  • This paper describes the use and occupational exposure to asbestos, and the incidence and mortality of malignant mesotheliomas in Korea.
  • Asbestos raw material imports from other countries peaked between 1990 and 1995, but importation of asbestos-containing and -processed materials has steadily increased until now.
  • The average airborne asbestos concentration was lower than from other countries and steadily decreased during the study period.
  • The number of malignant mesothelioma cases in Korea was 48 in 1998, 39 in 1999, 45 in 2000, 38 in 2001, and 46 in 2002.
  • There were 334 deaths due to malignant mesothelioma and an average of 30.4 deaths per year between 1996 and 2006.
  • The number of deaths attributed to malignant mesothelioma ranged from 16 cases in 1999 to 57 cases in 2006.
  • The magnitude of asbestos-related health problems in Korea has been underestimated due to under-diagnosis, incomplete reports, and shorter duration of exposure.
  • A nationwide surveillance system for asbestos exposure and malignant mesothelioma should therefore be implemented.
  • [MeSH-major] Asbestos / adverse effects. Mesothelioma / etiology. Occupational Exposure / adverse effects. Pleural Neoplasms / etiology


51. Barone-Adesi F, Ferrante D, Bertolotti M, Todesco A, Mirabelli D, Terracini B, Magnani C: Long-term mortality from pleural and peritoneal cancer after exposure to asbestos: Possible role of asbestos clearance. Int J Cancer; 2008 Aug 15;123(4):912-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term mortality from pleural and peritoneal cancer after exposure to asbestos: Possible role of asbestos clearance.
  • Models based on the multistage theory of carcinogenesis predict that the rate of mesothelioma increases monotonically as a function of time since first exposure (TSFE) to asbestos.
  • Some authors have suggested that the increase in mesothelioma rate with TSFE might be attenuated by clearance of asbestos from the lungs.
  • We estimated mortality time trends from pleural and peritoneal cancer in a cohort of 3,443 asbestos-cement workers, followed for more than 50 years.
  • The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalized to include a term representing elimination over time.
  • We observed 139 deaths from pleural and 56 from peritoneal cancer during the period 1950-2003.
  • The rate of pleural cancer increased during the first 40 years of TSFE and reached a plateau thereafter.
  • In contrast, the rate of peritoneal cancer increased monotonically with TSFE.
  • The model allowing for asbestos elimination fitted the data better than the traditional model for pleural (p = 0.02) but not for peritoneal cancer (p = 0.22).
  • The risk for pleural cancer, rather than showing an indefinite increase, might reach a plateau when a sufficiently long time has elapsed since exposure.
  • The different trends for pleural and peritoneal cancer might be related to clearance of the asbestos from the workers' lungs.
  • [MeSH-major] Asbestos, Crocidolite / pharmacokinetics. Asbestos, Serpentine / pharmacokinetics. Mesothelioma / mortality. Occupational Diseases / mortality. Occupational Exposure. Peritoneal Neoplasms / mortality. Pleural Neoplasms / mortality

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • [ErratumIn] Int J Cancer. 2012 Jun 15;130(12):E1
  • (PMID = 18528868.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Asbestos, Serpentine; 12001-28-4 / Asbestos, Crocidolite
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52. Peretz A, Van Hee VC, Kramer MR, Pitlik S, Keifer MC: Pleural plaques related to "take-home" exposure to asbestos: An international case series. Int J Gen Med; 2008;1:15-20
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  • [Title] Pleural plaques related to "take-home" exposure to asbestos: An international case series.
  • CONTEXT: While a large number of studies indicate the risks of high-level exposures to asbestos in the workplace setting, a relatively small number of studies describe the risk of pleural disease related to "take-home" asbestos brought into the household by workers exposed to asbestos.
  • Consequently, the risk of pleural disease in family members of asbestos-exposed workers is likely underappreciated.
  • CASE PRESENTATIONS: Two families of siblings, one in Israel and one in the US, were evaluated because of their significant exposures to asbestos brought into the home by family members with heavy occupational exposures.
  • Two of the four children of an asbestos cement debagger in Petach Tikvah, Israel and two children of a pipe lagger in a naval shipyard near Seattle, Washington, manifested benign pleural disease without parenchymal disease, despite having no occupational exposure to asbestos.
  • DISCUSSION: These cases illustrate that "take-home" asbestos exposure may lead to pleural disease at higher rates than commonly realized.
  • RELEVANCE TO CLINICAL PRACTICE: Providers should recognize that due to the potential for "take-home" exposures, asbestos-related disease in a patient may be a marker for disease in household contacts.
  • Patients with family members heavily exposed to asbestos should be strongly encouraged to quit smoking in an effort to reduce any further carcinogenic exposures.
  • Additionally, workplace control and regulation of asbestos use should be emphasized to protect both workers and their families.

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  • [Cites] Occup Environ Med. 2003 Jan;60(1):35-41; discussion 41-2 [12499455.001]
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  • (PMID = 20428401.001).
  • [ISSN] 1178-7074
  • [Journal-full-title] International journal of general medicine
  • [ISO-abbreviation] Int J Gen Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2840547
  • [Keywords] NOTNLM ; asbestos / case series / environmental / household / nonoccupational / pleural plaques / take-home
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53. Maurel M, Stoufflet A, Thorel L, Berna V, Gislard A, Letourneux M, Pairon JC, National Network of Asbestos Post-Exposure Survey, Paris C: Factors associated with cancer distress in the Asbestos Post-Exposure Survey (APEXS). Am J Ind Med; 2009 Apr;52(4):288-96
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  • [Title] Factors associated with cancer distress in the Asbestos Post-Exposure Survey (APEXS).
  • OBJECTIVES: CT-scan screening programs for lung cancer detection have been proposed in high-risk subjects, and more recently in former asbestos-exposed subjects.
  • The aim of this study is to examine the risk factors of psychological distress at baseline of a CT-scan screening program among asbestos-exposed subjects.
  • METHODS: The Asbestos Post-Exposure Survey (APEXS) was carried out in France between October 2003 and December 2005 in order to screen asbestos-related diseases by CT-scan.
  • Volunteers underwent self-administered questionnaires including an asbestos exposure assessment and, for a large sub-sample, a validated psychological distress scale.
  • This distress is associated independently with the self-perception of (i) intensity of asbestos exposure and (ii) the risk of current or future disease related to the asbestos exposure.
  • The perception of the cancer risk related to asbestos seems to play a fundamental role in this psychological distress.
  • CONCLUSION: In this study, asbestos-exposed subjects experienced a higher significant cancer distress than previously described in literature.
  • First, the impact of such occupational exposures on quality of life of patients who suffer from cancer related to these exposures has to be appraised.
  • Secondly, the assessment of psychological impact of CT-scan screening programs among asbestos-exposed subjects is also required.

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  • (PMID = 19152347.001).
  • [ISSN] 1097-0274
  • [Journal-full-title] American journal of industrial medicine
  • [ISO-abbreviation] Am. J. Ind. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Investigator] Ameille J; Aubert B; Baron J; Benichou J; Brochard P; Caillet A; Catilina P; Chammings S; Christ de Blasi G; Conso F; Gislard A; Guichard E; Lestang N; Letourneux M; Maurel M; Millet B; Mouchot L; Pairon JC; Paris C; Pinet M; Porte A; Rehel JL; Reungoat P; Schorle E; Sobaszek A; Stoufflet A; Thomas FX; Thorel L
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54. Creaney J, Olsen NJ, Brims F, Dick IM, Musk AW, de Klerk NH, Skates SJ, Robinson BW: Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma. Cancer Epidemiol Biomarkers Prev; 2010 Sep;19(9):2238-46
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  • [Title] Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma.
  • BACKGROUND: Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, primarily caused by exposure to asbestos.
  • Since the recent discovery that serum mesothelin is a sensitive and highly specific biomarker for mesothelioma, one of the key issues raised is whether mesothelin levels represent a useful screening test for asbestos-exposed at-risk individuals.
  • In this study, soluble mesothelin was determined in sequential serum samples collected from asbestos-exposed individuals before the development of mesothelioma.
  • METHODS: Archival serum samples from 106 individuals who developed mesothelioma, 99 asbestos-exposed individuals from the Wittenoom Cancer Surveillance Program, and 109 non-asbestos-exposed individuals from the Busselton Health Survey were identified.
  • RESULTS: Longitudinal mesothelin levels determined in healthy asbestos-exposed individuals over a period of 4 years were stable (Pearson's r = 0.96; P < 0.0001).
  • There was no correlation between mesothelin concentration and cumulative asbestos exposure.
  • [MeSH-major] Asbestos / adverse effects. Biomarkers, Tumor / blood. Membrane Glycoproteins / blood. Mesothelioma / blood. Mesothelioma / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Early Detection of Cancer / methods. Female. GPI-Linked Proteins / blood. Humans. Male. Middle Aged. Retrospective Studies

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  • [Copyright] (c)2010 AACR.
  • (PMID = 20651076.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin; 1332-21-4 / Asbestos
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55. Thomas DD, Espey MG, Pociask DA, Ridnour LA, Donzelli S, Wink DA: Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite. Cancer Res; 2006 Dec 15;66(24):11600-4
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  • [Title] Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite.
  • Asbestos exposure is strongly associated with the development of malignant mesothelioma, yet the mechanistic basis of this observation has not been resolved.
  • Carcinogenic transformation or tumor progression mediated by asbestos may be related to the generation of free radical species and perturbation of cell signaling and transcription factors.
  • We report here that exposure of human mesothelioma or lung carcinoma cells to nitric oxide (NO) in the presence of crocidolite asbestos resulted in a marked decrease in intracellular nitrosation and diminished NO-induced posttranslational modifications of tumor-associated proteins (hypoxia-inducible factor-1alpha and p53).
  • Nitrated protein adducts are a prominent feature of asbestos-induced lung injury.
  • These data highlight the ability of asbestos to induce phenotypic cellular changes through two processes: (a) by directly reducing bioactive NO levels and preventing its subsequent interaction with target molecules and (b) by increasing oxidative damage and protein modifications through NO(2) production and 3-nitrotyrosine formation.
  • [MeSH-major] Asbestos / pharmacology. Nitric Oxide / physiology. Nitrites / metabolism. Serum Albumin, Bovine / drug effects. Signal Transduction / drug effects

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  • (PMID = 17178853.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Nitrites; 0 / Serum Albumin, Bovine; 0 / Tumor Suppressor Protein p53; 1332-21-4 / Asbestos; 17885-08-4 / Phosphoserine; 31C4KY9ESH / Nitric Oxide
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56. Nymark P, Kettunen E, Aavikko M, Ruosaari S, Kuosma E, Vanhala E, Salmenkivi K, Pirinen R, Karjalainen A, Knuutila S, Wikman H, Anttila S: Molecular alterations at 9q33.1 and polyploidy in asbestos-related lung cancer. Clin Cancer Res; 2009 Jan 15;15(2):468-75
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  • [Title] Molecular alterations at 9q33.1 and polyploidy in asbestos-related lung cancer.
  • PURPOSE: Asbestos causes DNA damage and the fibers, together with tobacco smoke, have a synergistic effect on lung cancer risk.
  • We recently identified 18 chromosomal regions that showed differences in DNA copy number between the lung tumors of asbestos-exposed and nonexposed patients.
  • One of the previously identified asbestos-associated chromosomal regions at 9q was further analyzed for allelic imbalance and DNA copy number alterations (CNA) in the lung tumors of asbestos-exposed and nonexposed patients.
  • EXPERIMENTAL DESIGN: Allelic imbalance was analyzed at 9q31.3-34.3 with 15 microsatellite markers in 52 lung tumor samples from asbestos-exposed and nonexposed patients.
  • RESULTS: Allelic imbalance at 9q31.3-q34.3 was found in all asbestos-exposed patient tumors (100%, 17 of 17) compared with 64% (14 of 22) in the nonexposed cases (P = 0.005).
  • CONCLUSIONS: These results provide a basis for the development of a method to identify asbestos-related lung cancer on a molecular level.
  • [MeSH-major] Asbestos / adverse effects. Chromosomes, Human, Pair 9. Lung Neoplasms / chemically induced. Lung Neoplasms / genetics. Polyploidy

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  • (PMID = 19147751.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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57. Scarselli A, Binazzi A, Altavista P, Mastrantonio M, Uccelli R, Marinaccio A: [Malignant pleural cancers mortality and compensated cases for asbestos related diseases in Lazio municipalities (1980-2001)]. Med Lav; 2007 Jan-Feb;98(1):30-8
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  • [Title] [Malignant pleural cancers mortality and compensated cases for asbestos related diseases in Lazio municipalities (1980-2001)].
  • BACKGROUND: Occupational exposure to asbestos has been widely reported in the Region, but a high risk for non-occupational and environmental contaminations have also been documented.
  • OBJECTIVES: To describe the geographical distribution ofpleural cancer deaths and compensated asbestosis cases from 1980 to 2001 in the Lazio Region.
  • METHODS: For each municipality Standardized Mortality Ratios (SMRs) for pleural cancer and Standardized Incidence Ratios (SIRs) for asbestosis were estimated.
  • RESULTS: 789 deaths from pleural cancer (495 males and 294 females) occurred in Lazio from 1980 to 2001.
  • The main excess mortality from pleural cancer occurred in the municipalities of Civitavecchia (SMR: 269,9; 95% CI: 164,9 - 416,8), Colleferro (SMR: 304,9; 95% CI: 139,4-578,8) and Rocca Priora (SMR: 379,2; 95% CI: 103,3-970,9).
  • The most important clusters were identified in the municipality of Civitavecchia for pleural cancer (p-value = 0,117) and in the Colleferro industrial area for compensated asbestosis cases (p-value = 0,001).
  • CONCLUSIONS: Epidemiological surveillance of incident cases of malignant mesothelioma in the Lazio Region and the investigation of modalities of asbestos exposure are urgently needed for prevention of occupational diseases.

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  • (PMID = 17240643.001).
  • [ISSN] 0025-7818
  • [Journal-full-title] La Medicina del lavoro
  • [ISO-abbreviation] Med Lav
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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58. Musk AW, de Klerk NH, Reid A, Ambrosini GL, Fritschi L, Olsen NJ, Merler E, Hobbs MS, Berry G: Mortality of former crocidolite (blue asbestos) miners and millers at Wittenoom. Occup Environ Med; 2008 Aug;65(8):541-3
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  • [Title] Mortality of former crocidolite (blue asbestos) miners and millers at Wittenoom.
  • BACKGROUND: Blue asbestos was mined and milled at Wittenoom in Western Australia between 1943 and 1966.
  • METHODS: Nearly 7000 male workers who worked at the Wittenoom mine and mill have been followed up using death and cancer registries throughout Australia and Italy to the end of 2000.
  • Person-years at risk were derived using two censoring dates in order to produce minimum and maximum estimates of asbestos effect.
  • Mortality from lung cancer (SMR = 1.52), pneumoconiosis (SMR = 15.5), respiratory diseases (SMR = 1.58), tuberculosis (SMR = 3.06), digestive diseases (SMR = 1.47), alcoholism (SMR = 2.24) and symptoms, signs and ill defined conditions (SMR = 2.00) were greater in this cohort compared to the Western Australian male population.
  • CONCLUSION: Asbestos related diseases, particularly malignant mesothelioma, lung cancer and pneumoconiosis, continue to be the main causes of excess mortality in the former blue asbestos miners and millers of Wittenoom.
  • [MeSH-major] Asbestos, Crocidolite / toxicity. Mesothelioma / mortality. Mining. Occupational Exposure / adverse effects. Peritoneal Neoplasms / mortality. Respiratory Tract Diseases / mortality

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  • (PMID = 18045848.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 12001-28-4 / Asbestos, Crocidolite
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59. Takahashi K, Kang SK: Towards elimination of asbestos-related diseases: a theoretical basis for international cooperation. Saf Health Work; 2010 Dec;1(2):103-6

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  • [Title] Towards elimination of asbestos-related diseases: a theoretical basis for international cooperation.
  • We develop a theoretical framework for international cooperation that can be used for the elimination of asbestos-related diseases (ARDs).
  • The framework is based on the similarities in the temporal patterns of asbestos use and occurrence of ARDs in diverse countries.
  • The status of each nation can be characterized by observing asbestos use and ARD frequency therein using a time window.

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  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC3430887
  • [Keywords] NOTNLM ; Asbestos-related diseases / Asian Asbestos Initiative / Developing countries / International cooperation / Prevention
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60. Kamp DW: Asbestos-induced lung diseases: an update. Transl Res; 2009 Apr;153(4):143-52
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  • [Title] Asbestos-induced lung diseases: an update.
  • Asbestos causes asbestosis (pulmonary fibrosis caused by asbestos inhalation) and malignancies (bronchogenic carcinoma and mesothelioma) by mechanisms that are not fully elucidated.
  • Despite a dramatic reduction in asbestos use worldwide, asbestos-induced lung diseases remain a substantial health concern primarily because of the vast amounts of fibers that have been mined, processed, and used during the 20th century combined with the long latency period of up to 40 years between exposure and disease presentation.
  • Whereas the development of asbestosis is directly associated with the magnitude and duration of asbestos exposure, the development of a malignant clone of cells can occur in the setting of low-level asbestos exposure.
  • Emphasis is placed on the recent epidemiologic investigations that explore the malignancy risk that occurs from nonoccupational, environmental asbestos exposure.
  • Accumulating studies are shedding light on novel mechanistic pathways by which asbestos damages the lung.
  • The translational significance of these studies is evident in providing the molecular basis for developing novel therapeutic strategies for asbestos-related lung diseases and, importantly, other pulmonary diseases, such as interstitial pulmonary fibrosis and lung cancer.

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  • (PMID = 19304273.001).
  • [ISSN] 1931-5244
  • [Journal-full-title] Translational research : the journal of laboratory and clinical medicine
  • [ISO-abbreviation] Transl Res
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R01 ES013995; United States / NHLBI NIH HHS / HL / HL035440-21; United States / NHLBI NIH HHS / HL / R01 HL035440-21; United States / NIEHS NIH HHS / ES / ES013995-01A1; United States / NIEHS NIH HHS / ES / R01 ES013995-01A1
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 106
  • [Other-IDs] NLM/ NIHMS146578; NLM/ PMC3544481
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61. Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science; 2008 May 2;320(5876):674-7
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  • [Title] Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
  • The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer.
  • Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion.
  • ) In a model of asbestos inhalation, Nalp3-/- mice showed diminished recruitment of inflammatory cells to the lungs, paralleled by lower cytokine production.
  • Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor.

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  • (PMID = 18403674.001).
  • [ISSN] 1095-9203
  • [Journal-full-title] Science (New York, N.Y.)
  • [ISO-abbreviation] Science
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA114047-01A10002; United States / NCI NIH HHS / CA / P01 CA114047; United States / NCI NIH HHS / CA / P01 CA114047-01A10002; United States / NHLBI NIH HHS / HL / P01HL67004
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CIAS1 protein, mouse; 0 / Carrier Proteins; 0 / Inflammation Mediators; 0 / Interleukin-1beta; 1332-21-4 / Asbestos; 7631-86-9 / Silicon Dioxide
  • [Other-IDs] NLM/ NIHMS46658; NLM/ PMC2396588
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62. Chapman EA, Thomas PS, Yates DH: Breath analysis in asbestos-related disorders: a review of the literature and potential future applications. J Breath Res; 2010 Sep;4(3):034001
Hazardous Substances Data Bank. ASBESTOS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breath analysis in asbestos-related disorders: a review of the literature and potential future applications.
  • Asbestos usage was very common worldwide in the last century and continues in several countries today.
  • Several diseases occur due to asbestos exposure, including malignant tumours such as malignant mesothelioma of the pleura and lung cancer, which have a very poor prognosis.
  • Asbestos inhalation may also result in more benign conditions such as asbestosis (or pulmonary fibrosis due to asbestos), pleural plaques and pleural thickening.
  • It is predicted that asbestos-associated mortality and morbidity will continue to increase, but methods for diagnosing asbestos-related disease are currently invasive and unsuitable for an increasingly elderly population.
  • [MeSH-major] Asbestos / analysis. Asbestosis / diagnosis

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  • (PMID = 21383477.001).
  • [ISSN] 1752-7163
  • [Journal-full-title] Journal of breath research
  • [ISO-abbreviation] J Breath Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 1332-21-4 / Asbestos
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63. Amati M, Tomasetti M, Mariotti L, Tarquini LM, Valentino M, Santarelli L: Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk. Mutat Res; 2008 Aug-Sep;655(1-2):52-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk.
  • Epidemiological studies have shown that mortality from malignant mesothelioma (MM) and lung cancer have increased with increasing cumulative exposure to asbestos.
  • To investigate whether tumour-related biomarkers can contribute towards the evaluation of the carcinogenic risk in populations exposed to asbestos, the DNA adduct 8-hydroxy-2'-deoxyguanosine (80HdG), interleukine-6 (IL-6), platelet-derived growth factor (PDGF-BB), hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGFbeta) and soluble mesothelin-related peptides (SMRPs) were analysed in a cohort of workers differently exposed to asbestos fibres at the workplace.
  • A total of 119 subjects with a history of occupational exposure to asbestos underwent clinical examination and were interviewed by trained personnel, responding to a detailed questionnaire related to duration of asbestos exposure, smoking, and occupational task.
  • According to the occupational tasks, asbestos-exposed subjects were analysed for their asbestos cumulative dose and the association with the biomarkers was evaluated.
  • Among the occupational groups, maintenance workers, pipe fitters and electricians were exposed to a higher cumulative dose of asbestos fibres.
  • Exposure to asbestos significantly increased the steady-state content of 80HdG in DNA.
  • Elevated levels of 80HdG and IL-6 best reflected a high level of SMRPs, which is related to cell transformation.
  • Subjects heavily exposed to asbestos [> 60(ff/cm3) x years] showed also a higher level of angiogenic factors.
  • A combination of angiogenic biomarkers with a specific mesothelioma-biomarker such as SMRPs could be used for close surveillance of workers with a history of asbestos exposure.
  • [MeSH-major] Asbestos / adverse effects. Biomarkers, Tumor / blood. Mesothelioma / blood. Occupational Diseases / blood. Occupational Exposure. Pleural Neoplasms / blood

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  • (PMID = 18638565.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 1332-21-4 / Asbestos
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64. Zavalić M, Macan J: [Croatian and international regulations on the protection and rights of workers exposed to asbestos at work]. Arh Hig Rada Toksikol; 2009 Nov;60 Suppl:57-63
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  • [Title] [Croatian and international regulations on the protection and rights of workers exposed to asbestos at work].
  • New regulations on the protection and rights of workers occupationally exposed to asbestos were introduced in Croatia in 2007 and 2008.
  • They have been harmonised with the European Union (EU) and International Labour Organization (ILO) regulations, and make a step forward in safety at work, health protection, social rights, and pension schemes for Croatian workers occupationally exposed to asbestos.
  • The 2007 Croatian regulation on the protection of workers from the risks related to exposure to asbestos at work defines and describes activities in which workers can be occupationally exposed to asbestos, defines the threshold value of asbestos in the air at work, defines valid methods for measurement of asbestos concentrations in the air, and establishes measures to reduce asbestos exposure at work or protect the exposed workers.
  • Croatian law regulating obligatory health surveillance of workers occupationally exposed to asbestos from year 2007 defines activities and competent authorities to implement health surveillance of workers occupationally exposed to asbestos and to diagnose occupational diseases related to asbestos.
  • This law also defines "occupational exposure to asbestos", and "occupational asbestos-related diseases", including asbestosis (pulmonary asbestos-related fibrosis), pleural asbestos-related disorders (plaques, pleural thickening, and benign effusion), lung and bronchial cancer, and malignant mesothelioma of serous membranes.
  • These regulations have been harmonised with ILO, Directive 2003/18/EC amending Council Directive 83/477/EEC on the protection of workers from the risks related to exposure to asbestos at work, and with the Commission Recommendation 2003/670/EC concerning the European schedule of occupational diseases.
  • The 2008 Croatian regulation on conditions of health surveillance, diagnostic procedures and criteria for confirmation of occupational asbestos-related diseases "defines the terms and the content of medical examination of workers exposed to asbestos, and criteria for the confirmation of occupational asbestos-related diseases which are harmonised with the Helsinki criteria acknowledged by ILO and EU, particularly concerning the level and length of exposure.
  • Croatian law on compensation of workers occupationally exposed to asbestos from 2007 regulates compensation claims for workers with occupational asbestos-related disease, authorities competent to process these claims, and funds and coefficients for compensation payments.
  • Accordingly, Croatia is responsible for compensation claims payment for workers with occupational asbestos-related disease.
  • The 2007 law on conditions for entitlement to full pension for workers exposed to asbestos at work defines the conditions for fulfilling criteria for retirement pension for workers exposed to asbestos at work.
  • [MeSH-major] Asbestos / adverse effects. Occupational Exposure / legislation & jurisprudence. Occupational Health / legislation & jurisprudence

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  • (PMID = 20853780.001).
  • [ISSN] 0004-1254
  • [Journal-full-title] Arhiv za higijenu rada i toksikologiju
  • [ISO-abbreviation] Arh Hig Rada Toksikol
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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65. Ruosaari ST, Nymark PE, Aavikko MM, Kettunen E, Knuutila S, Hollmén J, Norppa H, Anttila SL: Aberrations of chromosome 19 in asbestos-associated lung cancer and in asbestos-induced micronuclei of bronchial epithelial cells in vitro. Carcinogenesis; 2008 May;29(5):913-7
Hazardous Substances Data Bank. ASBESTOS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrations of chromosome 19 in asbestos-associated lung cancer and in asbestos-induced micronuclei of bronchial epithelial cells in vitro.
  • Exposure to asbestos is known to induce lung cancer, and our previous studies have suggested that specific chromosomal regions, such as 19p13, are preferentially aberrant in lung tumours of asbestos-exposed patients.
  • Here, we further examined the association between the 19p region and exposure to asbestos using array comparative genomic hybridization and fluorescence in situ hybridization (FISH) in lung tumours and FISH characterization of asbestos-induced micronuclei (MN) in human bronchial epithelial BEAS 2B cells in vitro.
  • We detected an increased number of 19p losses in the tumours of asbestos-exposed patients in comparison with tumours from non-exposed subjects with similar distribution of tumour histology in both groups (13/33; 39% versus 3/25; 12%, P = 0.04).
  • In BEAS 2B cells, a 48 h exposure to crocidolite asbestos (2.0 microg/cm(2)) was found to induce centromere-negative MN-harbouring chromosomal fragments.
  • The results suggest that 19p has significance in asbestos-associated carcinogenesis and that asbestos may be capable of inducing specific chromosome aberrations.
  • [MeSH-major] Asbestos / toxicity. Bronchi / pathology. Chromosome Aberrations / drug effects. Chromosomes, Human, Pair 19 / drug effects. Epithelial Cells / pathology. Lung Neoplasms / genetics

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  • (PMID = 18339684.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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66. Silverstein MA, Welch LS, Lemen R: Developments in asbestos cancer risk assessment. Am J Ind Med; 2009 Nov;52(11):850-8
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  • [Title] Developments in asbestos cancer risk assessment.
  • BACKGROUND: Efforts have been made for 25 years to develop asbestos risk assessments that provide valid information about workplace and community cancer risks.
  • METHODS: Risk assessments prepared by USEPA, OSHA, and NIOSH since 1972 were reviewed, along with related literature.
  • RESULTS AND CONCLUSIONS: None of the efforts to use statistical models to characterize relative cancer potencies for asbestos fiber types and sizes have been able to overcome limitations of the exposure data.
  • However, while there may be genuine need for such work, a more pressing priority with regard to the six regulated forms of asbestos and other asbestiform fibers is to ban their production and use.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / epidemiology. Mesothelioma / epidemiology. Occupational Diseases / epidemiology. Pleural Neoplasms / epidemiology
  • [MeSH-minor] Asbestos, Crocidolite / adverse effects. Humans. Models, Statistical. Occupational Exposure. Risk Assessment. Workplace

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19757446.001).
  • [ISSN] 1097-0274
  • [Journal-full-title] American journal of industrial medicine
  • [ISO-abbreviation] Am. J. Ind. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 12001-28-4 / Asbestos, Crocidolite; 1332-21-4 / Asbestos
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67. Browne ML, Varadarajulu D, Lewis-Michl EL, Fitzgerald EF: Cancer incidence and asbestos in drinking water, Town of Woodstock, New York, 1980-1998. Environ Res; 2005 Jun;98(2):224-32
Hazardous Substances Data Bank. ASBESTOS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer incidence and asbestos in drinking water, Town of Woodstock, New York, 1980-1998.
  • Late in 1985, asbestos contamination was discovered in the public water supply of the Town of Woodstock, Ulster County, New York.
  • Contamination resulted from asbestos-cement pipes installed in the town water system in the mid to late 1950s and the corrosiveness of the local water.
  • The New York State (NYS) Department of Health established the Woodstock Asbestos Exposure Registry (WAER) in 1986 to monitor rates of cancer among individuals who lived on the water supply between 1960 and 1985.
  • The follow-up period for observation of cancer was 1980-1998, consistent with the expected lag of 20-30+ years for development of asbestos-related cancers.
  • The NYS Cancer Registry was used to ascertain cancer diagnoses.
  • For individual types of the gastrointestinal cancers, only the SIR for pancreatic cancer was marginally statistically significant at 2.19 (95% CI=1.00-4.16), based on a total of nine observed cases.
  • The excess in pancreatic cancer occurred primarily among men (SIR=3.08; 95% CI=1.13-6.70) and was only slightly elevated among women (SIR=1.39; 95% CI=0.29-4.06).
  • This association may be related to factors other than asbestos exposure such as occupation and lifestyle or to chance.
  • The general pattern of results did not demonstrate a likely link between exposure to asbestos in drinking water and cancer occurrence among participants in the WAER.
  • [MeSH-major] Asbestos / adverse effects. Neoplasms / epidemiology. Water Pollutants, Chemical / adverse effects. Water Supply / standards

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  • (PMID = 15820729.001).
  • [ISSN] 0013-9351
  • [Journal-full-title] Environmental research
  • [ISO-abbreviation] Environ. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Water Pollutants, Chemical; 1332-21-4 / Asbestos
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68. Horton DK, Bove F, Kapil V: Select mortality and cancer incidence among residents in various U.S. communities that received asbestos-contaminated vermiculite ore from Libby, Montana. Inhal Toxicol; 2008 Jun;20(8):767-75
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  • [Title] Select mortality and cancer incidence among residents in various U.S. communities that received asbestos-contaminated vermiculite ore from Libby, Montana.
  • In response to the significantly elevated asbestosis mortality rates found in Libby, Montana, in 2000, this analysis evaluated whether other communities throughout the United States that received asbestos-contaminated vermiculite ore from Libby experienced similar excess rates of asbestos-related diseases.
  • Standardized mortality ratios were calculated using state death certificates, and standardized incidence ratios were calculated using cancer registry records for populations living near facilities that processed or received Libby vermiculite.
  • This analysis focused primarily on diseases that are directly associated with asbestos exposure (e.g., asbestosis; cancer of the peritoneum, retroperitoneum, and pleura, including mesothelioma; and mesothelioma).
  • Lung cancer and cancers of the digestive system, also associated with asbestos exposure, were not included in the analysis because they have additional risk factors for which exposure information was not available.
  • No statistically significant excesses of asbestosis mortality similar to those in Libby were noted; however, 11 sites (plus a state with 6 pooled sites that were counted as 1 site) had excess rates of mesothelioma and cancer of the peritoneum, retroperitoneum, and pleura.
  • Further investigation should be conducted at these sites with excess rates of mesothelioma and cancer of the peritoneum, retroperitoneum, and pleura by participating state health departments to determine whether exposure to Libby vermiculite might have been a contributing factor.
  • [MeSH-major] Aluminum Silicates / toxicity. Asbestos / toxicity. Asbestosis / mortality. Environmental Monitoring / methods. Mining. Neoplasms / epidemiology

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  • (PMID = 18569099.001).
  • [ISSN] 1091-7691
  • [Journal-full-title] Inhalation toxicology
  • [ISO-abbreviation] Inhal Toxicol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aluminum Silicates; 1318-00-9 / vermiculite; 1332-21-4 / Asbestos
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69. Marinaccio A, Binazzi A, Cauzillo G, Cavone D, Zotti RD, Ferrante P, Gennaro V, Gorini G, Menegozzo M, Mensi C, Merler E, Mirabelli D, Montanaro F, Musti M, Pannelli F, Romanelli A, Scarselli A, Tumino R, Italian Mesothelioma Register (ReNaM) Working Group: Analysis of latency time and its determinants in asbestos related malignant mesothelioma cases of the Italian register. Eur J Cancer; 2007 Dec;43(18):2722-8
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  • [Title] Analysis of latency time and its determinants in asbestos related malignant mesothelioma cases of the Italian register.
  • Italy was an important producer of raw asbestos until 1992 (when it was banned) and it is now experiencing severe public health consequences due to large-scale industrial use of asbestos in shipbuilding and repair, asbestos-cement production, railways, buildings, chemicals and many other industrial sectors.
  • Latency of malignant mesothelioma generally shows a large variability and the relationship with the modality of asbestos exposure is still not fully clarified.
  • We present an analysis of latency period among the case list collected by the Italian mesothelioma register (ReNaM) in the period of diagnosis 1993-2001 (2544 malignant mesothelioma (MM) cases with asbestos exposure history).
  • The role of diagnostic confidence level, the morphology of the tumour and the modalities of asbestos exposure were verified in a regression multivariate model.
  • [MeSH-major] Asbestos / toxicity. Environmental Exposure / adverse effects. Heart Neoplasms / epidemiology. Mesothelioma / epidemiology. Peritoneal Neoplasms / epidemiology. Pleural Neoplasms / epidemiology. Testicular Neoplasms / epidemiology


70. Blake DJ, Bolin CM, Cox DP, Cardozo-Pelaez F, Pfau JC: Internalization of Libby amphibole asbestos and induction of oxidative stress in murine macrophages. Toxicol Sci; 2007 Sep;99(1):277-88

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  • [Title] Internalization of Libby amphibole asbestos and induction of oxidative stress in murine macrophages.
  • The community members of Libby, MT, have experienced significant asbestos exposure and developed numerous asbestos-related diseases including fibrosis and lung cancer due to an asbestos-contaminated vermiculite mine near the community.
  • The form of asbestos in the contaminated vermiculite has been characterized in the amphibole family of fibers.
  • The purpose of this study is to determine the cellular consequences of Libby amphibole exposure in macrophages compared to another well-characterized amphibole fiber; crocidolite asbestos.
  • Our results indicate that Libby asbestos fibers are internalized by macrophages and localize to the cytoplasm and cytoplasmic vacuoles similar to crocidolite fibers.
  • Libby asbestos fiber internalization generates a significant increase in intracellular reactive oxygen species (ROS) as determined by dichlorofluorescein diacetate and dihydroethidine fluorescence indicating that the superoxide anion is the major contributing ROS generated by Libby asbestos.
  • Elevated superoxide levels in macrophages exposed to Libby asbestos coincide with a significant suppression of total superoxide dismutase activity.
  • Both Libby and crocidolite asbestos generate oxidative stress in exposed macrophages by decreasing intracellular glutathione levels.
  • Interestingly crocidolite asbestos, but not Libby asbestos, induces significant DNA damage in macrophages.
  • This study provides evidence that the difference in the level of DNA damage observed between Libby and crocidolite asbestos may be a combined consequence of the distinct chemical compositions of each fiber as well as the activation of separate cellular pathways during asbestos exposure.
  • [MeSH-major] Asbestos, Amphibole / toxicity. Macrophages / drug effects. Oxidative Stress / drug effects
  • [MeSH-minor] Animals. Asbestos, Crocidolite / metabolism. Asbestos, Crocidolite / toxicity. Cell Line. DNA Damage. DNA Glycosylases / metabolism. Dose-Response Relationship, Drug. Mice. Montana. Reactive Oxygen Species / metabolism. Superoxide Dismutase / metabolism

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  • (PMID = 17578862.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Grant] United States / PHS HHS / / P20 017670; United States / NIEHS NIH HHS / ES / R21 ES012956
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Asbestos, Amphibole; 0 / Reactive Oxygen Species; 12001-28-4 / Asbestos, Crocidolite; EC 1.15.1.1 / Superoxide Dismutase; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / Ogg1 protein, mouse
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71. Neumann V, Kraus T, Fischer M, Löseke S, Tannapfel A: [Relevance of pathological examinations and lung dust analyses in the context of asbestos-associated lung cancer-No. 4104 of the list of occupational diseases in Germany]. Pneumologie; 2009 Oct;63(10):588-93
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  • [Title] [Relevance of pathological examinations and lung dust analyses in the context of asbestos-associated lung cancer-No. 4104 of the list of occupational diseases in Germany].
  • This report discusses the relevance of pathological-anatomical examinations and lung dust analyses in the context of asbestos-related lung cancer on the basis of three case reports.
  • The cases one and two demonstrate a limited performance of conventional computed tomography scanning with a resolution of 3 mm for the detection of asbestos-related pleural diseases.
  • As shown here, pathological-anatomic examinations including lung dust analysis are highly valuable for the estimation of asbestos-related lung diseases.
  • [MeSH-major] Asbestos / toxicity. Asbestosis / epidemiology. Lung Neoplasms / epidemiology. Occupational Diseases / epidemiology. Pleural Diseases / epidemiology


72. Neri M, Taioli E, Filiberti R, Paolo Ivaldi G, Aldo Canessa P, Verna A, Marroni P, Puntoni R, Hirvonen A, Garte S: Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations. Int J Hyg Environ Health; 2006 Jul;209(4):393-8
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  • [Title] Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.
  • The role of CYP1A1, GSTM1, GSTT1, EPHX1, and NAT2 genotypes in susceptibility to malignant mesothelioma (MM) was compared in two case-control studies, previously conducted in two countries where different types of asbestos fibers have been used [Hirvonen et al., 1995.
  • Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma.
  • Cancer Res. 55, 2981-2983; Hirvonen et al., 1996.
  • Glutathione S-Transferase and N-Acetyltransferase genotypes and asbestos-associated pulmonary disorders. J. Natl.
  • Cancer Inst.88, 1853-1856; Neri et al., 2005.
  • Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. Mutat. Res. 592, 36-44].
  • Fifty-seven asbestos-exposed MM patients and 255 controls were recruited in Italy, 48 cases and 121 controls in Finland.
  • The opposite results obtained in Finland and Italy may be ascribed to random chance, but a role may be hypothesized for the fact that different types of asbestos have been used in the two countries.
  • [MeSH-major] Asbestos / toxicity. Genetic Predisposition to Disease. Mesothelioma / genetics. Pleural Neoplasms / genetics

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  • (PMID = 16697254.001).
  • [ISSN] 1438-4639
  • [Journal-full-title] International journal of hygiene and environmental health
  • [ISO-abbreviation] Int J Hyg Environ Health
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 1332-21-4 / Asbestos; EC 2.3.1.5 / Arylamine N-Acetyltransferase; EC 2.3.1.5 / NAT2 protein, human; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1; EC 3.3.2.- / Epoxide Hydrolases
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73. Pierce JS, McKinley MA, Paustenbach DJ, Finley BL: An evaluation of reported no-effect chrysotile asbestos exposures for lung cancer and mesothelioma. Crit Rev Toxicol; 2008;38(3):191-214
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  • [Title] An evaluation of reported no-effect chrysotile asbestos exposures for lung cancer and mesothelioma.
  • Numerous investigators have suggested that there is likely to be a cumulative chrysotile exposure below which there is negligible risk of asbestos-related diseases.
  • However, to date, little research has been conducted to identify an actual "no-effect" exposure level for chrysotile-related lung cancer and mesothelioma.
  • Fourteen studies meeting the inclusion criteria were found where lung cancer risk was stratified by cumulative chrysotile exposure; four such studies were found for mesothelioma.
  • The preponderance of the cumulative "no-effects" exposure levels for lung cancer and mesothelioma fall in a range of approximately 25-1,000 fibers per cubic centimeter per year (f/cc-yr) and 15-500 f/cc-yr, respectively, and a majority of the studies did not report an increased risk at the highest estimated exposure.
  • Specifically, the range of chrysotile NOAELs were found to be consistently higher than upper-bound cumulative chrysotile exposure estimates that have been published for pre-1980s automobile mechanics (e.g., 95th percentile of 2.0 f/ cc-yr), an occupation that historically worked with chrysotile-containing friction products yet has been shown to have no increased risk of asbestos-related diseases.
  • While the debate regarding chrysotile as a risk factor for mesothelioma will likely continue for some time, future research into nonlinear, threshold cancer risk models for chrysotile-related respiratory diseases appears to be warranted.
  • [MeSH-major] Asbestos, Serpentine / toxicity. Lung Neoplasms / etiology. Mesothelioma / etiology

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  • (PMID = 18324516.001).
  • [ISSN] 1040-8444
  • [Journal-full-title] Critical reviews in toxicology
  • [ISO-abbreviation] Crit. Rev. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Asbestos, Serpentine
  • [Number-of-references] 92
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74. Das M, Mühlenbruch G, Mahnken AH, Hering KG, Sirbu H, Zschiesche W, Knoll L, Felten MK, Kraus T, Günther RW, Wildberger JE: Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT. Eur Radiol; 2007 May;17(5):1193-9
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  • [Title] Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT.
  • The purpose of this study was to assess the prevalence of lung cancer in a high-risk asbestos-exposed cohort using low-dose MDCT.
  • Of a population of 5,389 former power-plant workers, 316 were characterized as individuals at highest risk for lung cancer according to a lung-cancer risk model including age, asbestos exposure and smoking habits.
  • Mean asbestos exposure time was 29.65 years and 89% were smokers.
  • One strongly suspicious mass and eight cases of histologically proven lung cancer were found plus 491 additional pulmonary nodules (average volume: 40.72 ml, average diameter 4.62 mm).
  • Asbestos-related changes (pleural plaques, fibrosis) were visible in 80 individuals.
  • Lung cancer screening in this high-risk cohort showed a prevalence of lung cancer of 4.28% (8/187) at baseline screening with an additional large number of indeterminate pulmonary nodules.


75. Anastasiadou K, Gidarakos E: Toxicity evaluation for the broad area of the asbestos mine of northern Greece. J Hazard Mater; 2007 Jan 2;139(1):9-18
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  • [Title] Toxicity evaluation for the broad area of the asbestos mine of northern Greece.
  • The existing data regarding the quality of the environment in the asbestos mine of northern Greece (MABE) region related to the presence of asbestos are insufficient to determine the current pollution problem.
  • The environmental quality of an open air asbestos mine was evaluated over a long period of time by measuring and monitoring the concentration of asbestos fibres in air, soil and water.
  • Air measurements were made to determine the concentration of asbestos fibres in the atmospheric air of the mine, the depositions and the nearby villages.
  • The asbestos fibre concentration was also specified inside the building facilities of MABE.
  • Analyses of soil, dust and water samples were carried out showing the presence of enormous quantities of chrysotile asbestos.
  • The concentration of asbestos fibres in the atmospheric air was compared to older measurements that were taken at the same sampling points during the operation of the mine.
  • In addition, mathematical models based on human and animal studies were used to estimate the probability of a person developing cancer from breathing air containing asbestos fibres in the wider vicinity of the mine in order to define appropriate procedures for evaluating asbestos-related risk.
  • [MeSH-major] Asbestos / toxicity. Mining

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  • (PMID = 16889894.001).
  • [ISSN] 0304-3894
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Mineral Fibers; 059QF0KO0R / Water; 1332-21-4 / Asbestos
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76. Hosoda Y, Hiraga Y, Sasagawa S: Railways and asbestos in Japan (1928-1987)--epidemiology of pleural plaques, malignancies and pneumoconioses-. J Occup Health; 2008;50(4):297-307
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  • [Title] Railways and asbestos in Japan (1928-1987)--epidemiology of pleural plaques, malignancies and pneumoconioses-.
  • Asbestos has been an indispensable insulating material for railway industries, especially steam locomotives (SLs).
  • 1) Pleural plaques: Since the 1970s, pleural plaques have been regarded as evidence of past asbestos inhalation, and more recently recognized as a risk factor of asbestos-related malignancies.
  • The manifestation of pleural plaques was more correlated to years since the onset of the asbestos exposure than the sum of asbestos work years, although the result was not significant.
  • 2) Asbestos-related malignancies: Five retrospective cohort studies 1960-1970 were made on primary lung cancer incidence and mortality among 350,000 active railway men with smoking information.
  • 3) Pneumoconioses: Most studies (1928-1975) had relatively low prevalence rates among SL-related workers.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / epidemiology. Occupational Exposure. Pleural Diseases / epidemiology. Pneumoconiosis / epidemiology. Railroads

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  • (PMID = 18493113.001).
  • [ISSN] 1348-9585
  • [Journal-full-title] Journal of occupational health
  • [ISO-abbreviation] J Occup Health
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 72
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77. Park EK, Thomas PS, Johnson AR, Yates DH: Osteopontin levels in an asbestos-exposed population. Clin Cancer Res; 2009 Feb 15;15(4):1362-6
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  • [Title] Osteopontin levels in an asbestos-exposed population.
  • PURPOSE: Serum osteopontin levels in patients with malignant mesothelioma have been reported to be higher than in healthy subjects.
  • This study assessed serum osteopontin levels in an asbestos-exposed population to test whether nonmalignant asbestos-related disorders could influence osteopontin levels.
  • Subjects were classified into six different diagnostic groups, including asbestosis (n=23), silicosis (n=20), diffuse pleural thickening (n=110), asbestosis and diffuse pleural thickening (n=13), pleural plaques (n=142), and healthy subjects with a history of asbestos exposure (n=217).
  • Mean osteopontin values of the healthy individuals exposed to asbestos were significantly different from that of subjects with asbestosis (P<0.001) and diffuse pleural thickening (P<0.001).
  • There was a significant difference in mean serum levels of osteopontin in healthy individuals exposed to asbestos (n=217) compared with the group mean of all subjects with asbestos-related disorders (n=288; P<0.0001).
  • CONCLUSIONS: Our results suggest that osteopontin levels are elevated in subjects with asbestos-related disorders without malignant mesothelioma.
  • These data indicate that osteopontin, although reported to be useful for detecting malignant mesothelioma in asbestos-exposed individuals, may be influenced by nonmalignant processes.
  • [MeSH-major] Asbestos / adverse effects. Occupational Exposure. Osteopontin / blood

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  • (PMID = 19174489.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 106441-73-0 / Osteopontin; 1332-21-4 / Asbestos
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78. Kraus T, Borsch-Galetke E, Elliehausen HJ, Frank K, Hering KG, Hieckel HG, Hofmann-Preiss K, Jacques W, Jeremie U, Kotschy-Lang N, Mannes E, Otten H, Raab W, Raithel HJ, Schneider WD, Tuengerthal S: [Recommendations for reporting benign asbestos-related findings in chest X-ray and CT to the accident insurances]. Pneumologie; 2009 Dec;63(12):726-32
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  • [Title] [Recommendations for reporting benign asbestos-related findings in chest X-ray and CT to the accident insurances].
  • Asbestos-related diseases still play an important role in occupational medicine.
  • The detection of benign asbestos-related diseases is one condition for the compensation of asbestos-related lung cancer in Germany.
  • Due to the increasing use of computed tomography, asbestos-related diseases are more frequently detected in the early stages.
  • The present article proposes recommendations for the findings which have to be reported as suspicious for being asbestos-related based on a) chest X-rays and b) computed tomography using the International Classification System for Occupational and Environmental Respiratory Diseases (ICOERD).

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  • [Copyright] Georg Thieme Verlag KG Stuttgart-New York.
  • (PMID = 19937572.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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79. Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Goodman GE, Hammar SP, Thornquist MD, Omenn GS: Predictors of lung cancer among asbestos-exposed men in the {beta}-carotene and retinol efficacy trial. Am J Epidemiol; 2005 Feb 1;161(3):260-70
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  • [Title] Predictors of lung cancer among asbestos-exposed men in the {beta}-carotene and retinol efficacy trial.
  • Despite numerous published studies, debate continues regarding the risk of developing lung cancer among men exposed occupationally to asbestos, particularly those without radiographic or functional evidence of asbestosis.
  • The beta-Carotene and Retinol Efficacy Trial (CARET), a study of vitamin supplementation for chemoprevention of lung cancer, has followed 4,060 heavily exposed US men for 9-17 years.
  • Lung cancer incidence for 1989-2002 was analyzed using a stratified proportional hazards model.
  • The study confirmed excessive rates of lung cancer among men with radiographic asbestosis.
  • In the large subgroup of men with normal lung parenchyma on chest radiograph at baseline, there was evidence of exposure-related lung cancer risk: Men with more than 40 years' exposure in high-risk trades had a risk approximately fivefold higher than men with 5-10 years, after adjustment for covariates.
  • The effect in these men was independent of study intervention arm, but pleural plaques on the baseline radiograph and abnormal baseline flow rate were strong independent predictors of subsequent lung cancer.
  • Residual confounding by subclinical asbestosis, exposure to unmeasured lung carcinogens, or differences in smoking are unlikely to explain these observations better than a carcinogenic effect of asbestos per se.

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  • (PMID = 15671258.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01 CA63673
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 01YAE03M7J / beta Carotene; 11103-57-4 / Vitamin A
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80. Wikman H, Ruosaari S, Nymark P, Sarhadi VK, Saharinen J, Vanhala E, Karjalainen A, Hollmén J, Knuutila S, Anttila S: Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer. Oncogene; 2007 Jul 12;26(32):4730-7
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  • [Title] Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer.
  • Asbestos is a pulmonary carcinogen known to give rise to DNA and chromosomal damage, but the exact carcinogenic mechanisms are still largely unknown.
  • In this study, gene expression arrays were performed on lung tumor samples from 14 heavily asbestos-exposed and 14 non-exposed patients matched for other characteristics.
  • Using a two-step statistical analysis, 47 genes were revealed that could differentiate the tumors of asbestos-exposed from those of non-exposed patients.
  • To identify asbestos-associated regions with DNA copy number and expressional changes, the gene expression data were combined with comparative genomic hybridization microarray data.
  • As a result, a combinatory profile of DNA copy number aberrations and expressional changes significantly associated with asbestos exposure was obtained.
  • Asbestos-related areas were detected in 2p21-p16.3, 3p21.31, 5q35.2-q35.3, 16p13.3, 19p13.3-p13.1 and 22q12.3-q13.1.
  • In adenocarcinomas, AI in 19p appeared to occur independently of the asbestos exposure.
  • [MeSH-major] Adenocarcinoma / chemically induced. Allelic Imbalance. Asbestos / toxicity. Carcinogens / toxicity. Chromosomes, Human, Pair 19 / genetics. Lung Neoplasms / chemically induced. Occupational Exposure


81. Magnani C, Ferrante D, Barone-Adesi F, Bertolotti M, Todesco A, Mirabelli D, Terracini B: Cancer risk after cessation of asbestos exposure: a cohort study of Italian asbestos cement workers. Occup Environ Med; 2008 Mar;65(3):164-70
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  • [Title] Cancer risk after cessation of asbestos exposure: a cohort study of Italian asbestos cement workers.
  • OBJECTIVES: We aimed to study mortality for asbestos related diseases and the incidence of mesothelioma in a cohort of Italian asbestos cement workers after cessation of asbestos exposure.
  • RESULTS: Mortality was increased in both sexes for all causes (overall 1809 observed (obs) vs 1312.3 expected (exp); p<0.01), pleural (135 obs vs 3.6 exp; p<0.01) and peritoneal (52 vs 1.9; p<0.01) malignancies and lung cancer (249 vs 103.1; p<0.01).
  • No statistically significant increase was found for laryngeal cancer (16 obs vs 12.2 exp).
  • In Poisson regression analyses, the RR of death from pleural neoplasm linearly increased with duration of exposure, while it showed a curvilinear increase with latency and time since cessation of exposure.
  • RR for peritoneal neoplasm continued to increase by latency, duration and time since cessation of exposure.
  • RR for lung cancer showed a reduction after 15 years since cessation of exposure and levelled off after 40 years of latency.
  • CONCLUSION: This study of a cohort of asbestos exposed workers with very long follow-up confirmed the reduction in risk of death from lung cancer after the end of exposure.
  • [MeSH-major] Asbestos. Industry. Mesothelioma / mortality. Neoplasms / mortality. Occupational Diseases / mortality. Occupational Exposure

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  • (PMID = 17704197.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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82. Lee SF, O'Connor MM, Chapman Y, Hamilton V, Francis K: A very public death: dying of mesothelioma and asbestos-related lung cancer (M/ARLC) in the Latrobe Valley, Victoria, Australia. Rural Remote Health; 2009 Jul-Sep;9(3):1183
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  • [Title] A very public death: dying of mesothelioma and asbestos-related lung cancer (M/ARLC) in the Latrobe Valley, Victoria, Australia.
  • INTRODUCTION: It is anticipated that in Australia the number of cases of mesothelioma will continue to rise significantly over the next 15 years with power station workers having a risk second only to asbestos mill workers.
  • Mesothelioma responds poorly to treatment and is almost always fatal, yet there have been few studies related to the palliative care needs of this diagnostic group and none focussing on the Latrobe Valley, Victoria, Australia.
  • The aims of this pilot study were to identify common issues and to explore the needs and experiences of people with mesothelioma and asbestos-related lung cancer (M/ARLC), their carers, and service providers in the Latrobe Valley community, in particular in relation to palliative care.
  • Most people with M/ARLC in the Latrobe Valley are older males who were employed by the electricity and related industries, while their carers are mostly female wives and daughters.
  • Although there are some cancer treatment and legal services locally, people with M/ARLC are often required to travel to metropolitan services for care and advice.
  • Participants expressed the tension between feelings of loyalty to their employers and anger at the perceived betrayal of the same employers, who were reported to have ignored asbestos warnings.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / etiology. Mesothelioma / mortality. Terminally Ill

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  • (PMID = 19731971.001).
  • [ISSN] 1445-6354
  • [Journal-full-title] Rural and remote health
  • [ISO-abbreviation] Rural Remote Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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83. Phanprasit W, Sujirarat D, Chaikittiporn C: Health risk among asbestos cement sheet manufacturing workers in Thailand. J Med Assoc Thai; 2009 Dec;92 Suppl 7:S115-20
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  • [Title] Health risk among asbestos cement sheet manufacturing workers in Thailand.
  • OBJECTIVE: To assess asbestos exposure and calculate the relative risks of lung cancer among asbestos cement roof sheet workers and to predict the incidence rate of lung cancer caused by asbestos in Thailand.
  • MATERIAL AND METHOD: A cross-sectional study was conducted in four asbestos cement roof factories.
  • The relative risk (RR) of lung cancer among asbestos cement sheet workers was calculated and the number of asbestos related lung cancer case was estimated.
  • RESULTS: The roof fitting polishers had the highest exposure to airborne asbestos fiber (0.73 fiber/ml).
  • The estimated cumulative exposure for the workers performed studied-tasks ranged in between 90.13-115.65 fiber-years/ml while the relative risk of lung cancer calculated using US.
  • Based on the obtained RR, lung cancer among AC sheet in Thailand would be 2 case/year.
  • Furthermore, due to the environmental persistence of asbestos fiber, its life cycle analysis should be conducted in order to control environmental exposure of general population.
  • [MeSH-major] Asbestos / toxicity. Lung Neoplasms / epidemiology. Manufactured Materials / toxicity. Occupational Exposure / adverse effects

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  • (PMID = 20235362.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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84. Heintz NH, Janssen-Heininger YM, Mossman BT: Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol; 2010 Feb;42(2):133-9
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  • [Title] Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways.
  • Fifteen years have passed since we published findings in the AJRCMB demonstrating that induction of early response fos/jun proto-oncogenes in rodent tracheal and mesothelial cells correlates with fibrous geometry and pathogenicity of asbestos.
  • Our study was the first to suggest that the aberrant induction of signaling responses by crocidolite asbestos and erionite, a fibrous zeolite mineral associated with the development of malignant mesotheliomas (MMs) in areas of Turkey, led to altered gene expression.
  • New data questioned the widely held belief at that time that the carcinogenic effects of asbestos in the development of lung cancer and MM were due to genotoxic or mutagenic effects.
  • Later studies by our group revealed that proto-oncogene expression and several of the signaling pathways activated by asbestos were redox dependent, explaining why antioxidants and antioxidant enzymes were elevated in lung and pleura after exposure to asbestos and how they alleviated many of the phenotypic and functional effects of asbestos in vitro or after inhalation.
  • Since these original studies, our efforts have expanded to understand the interface between asbestos-induced redox-dependent signal transduction cascades, the relationship between these pathways and cell fate, and the role of asbestos and cell interactions in development of asbestos-associated diseases.
  • Of considerable significance is the fact that the signal transduction pathways activated by asbestos are also important in survival and chemoresistance of MMs and lung cancers.
  • An understanding of the pathogenic features of asbestos fibers and dysregulation of signaling pathways allows strategies for the prevention and therapy of asbestos-related diseases.
  • [MeSH-major] Asbestos / toxicity. Lung Neoplasms / etiology. Mesothelioma / etiology

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  • (PMID = 20068227.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / Oxidants; 0 / Proto-Oncogene Proteins c-fos; 0 / Proto-Oncogene Proteins c-jun; 0 / Receptors, Tumor Necrosis Factor; 0 / Transcription Factor AP-1; 1332-21-4 / Asbestos; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Number-of-references] 78
  • [Other-IDs] NLM/ PMC2822975
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85. Park EK, Sandrini A, Yates DH, Creaney J, Robinson BW, Thomas PS, Johnson AR: Soluble mesothelin-related protein in an asbestos-exposed population: the dust diseases board cohort study. Am J Respir Crit Care Med; 2008 Oct 15;178(8):832-7
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  • [Title] Soluble mesothelin-related protein in an asbestos-exposed population: the dust diseases board cohort study.
  • RATIONALE: Soluble mesothelin-related protein (SMRP) is raised in epithelial-type malignant mesothelioma (MM), but the utility of SMRP in screening for MM is unknown.
  • OBJECTIVES: We aimed to evaluate SMRP in an asbestos-exposed cohort.
  • MEASUREMENTS AND MAIN RESULTS: Mean (+/-SD) SMRP in healthy subjects exposed to asbestos (n = 223) was 0.79 (+/-0.45) nM.
  • Fifteen subjects had elevated SMRP, of whom one had lung cancer, which was successfully resected.
  • Another with lung cancer was undetected by SMRP.
  • CONCLUSIONS: This is the first large-scale prospective study of SMRP for screening for malignancy in asbestos-exposed individuals.
  • [MeSH-major] Asbestos / adverse effects. Membrane Glycoproteins / biosynthesis. Mesothelioma / diagnosis. Occupational Diseases / diagnosis. Occupational Exposure / adverse effects. Pleural Neoplasms / diagnosis

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  • [CommentIn] Am J Respir Crit Care Med. 2008 Oct 15;178(8):781-2 [18832552.001]
  • [CommentIn] Am J Respir Crit Care Med. 2009 May 1;179(9):851; author reply 851-852 [19383930.001]
  • (PMID = 18583574.001).
  • [ISSN] 1535-4970
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins; 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / mesothelin; 1332-21-4 / Asbestos
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86. Mirabelli D, Cavone D, Merler E, Gennaro V, Romanelli A, Mensi C, Chellini E, Nicita C, Marinaccio A, Magnani C, Musti M: Non-occupational exposure to asbestos and malignant mesothelioma in the Italian National Registry of Mesotheliomas. Occup Environ Med; 2010 Nov;67(11):792-4
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  • [Title] Non-occupational exposure to asbestos and malignant mesothelioma in the Italian National Registry of Mesotheliomas.
  • BACKGROUND: Malignant mesotheliomas are strictly related to asbestos, but in a proportion of cases no exposure can be recalled.
  • Historical and geographical differences in the fraction of cancer due to any given exposure are to be expected, but incomplete identification of non-occupational exposures may have played a role.
  • METHODS: To assess the role of non-occupational exposures in causing malignant mesotheliomas in Italy, the exposures of cases registered by the national mesothelioma registry (ReNaM) were examined.
  • RESULTS: From 1993 to 2001 ReNaM registered 5173 malignant mesothelioma cases, and exposures were assessed in 3552 of them.
  • 144 and 150 cases with exposures limited to environmental (living in the neighbourhood of an industrial or natural source of asbestos) or familial (living with a person occupationally exposed to asbestos) circumstances, respectively, were identified, accounting for 8.3% of all cases.
  • CONCLUSIONS: Geographical variations in the proportion of cases due to non-occupational exposures may be explained by the past distribution of asbestos-using industries.
  • [MeSH-major] Asbestos / toxicity. Environmental Exposure / adverse effects. Mesothelioma / etiology

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  • (PMID = 20959396.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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87. Yasuda M, Hanagiri T, Shigematsu Y, Onitsuka T, Kuroda K, Baba T, Mizukami M, Ichiki Y, Uramoto H, Takenoyama M, Yasumoto K: Identification of a tumour associated antigen in lung cancer patients with asbestos exposure. Anticancer Res; 2010 Jul;30(7):2631-9
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  • [Title] Identification of a tumour associated antigen in lung cancer patients with asbestos exposure.
  • BACKGROUND: This study analysed the humoral immune response in asbestos exposed lung cancer patients to identify new surrogate markers of the carcinogenic risk in populations exposed to asbestos.
  • METHODS AND RESULTS: A serological analysis identified five distinct antigens reactive with IgG derived from a lung cancer patient with high asbestos exposure.
  • In one of the isolated antigens, quantitative RT-PCR indicated that annexin A2 (AnxA2) was overexpressed in lung cancer tissues and normal lung from patients with high asbestos exposure.
  • Antibody against AnxA2 was detected in 9/15 (60%) of lung cancer patients with high asbestos exposure; however, in only 1/12 (8%) of lung cancer patients with low asbestos exposure.
  • AnxA2 was also overexpressed in malignant mesothelioma cells, and the antibody was also positive in 8/15 (53%) of patients with malignant mesothelioma.
  • CONCLUSION: The antibody titer against AnxA2 may be a potentially useful new diagnostic surrogate marker for asbestos-related lung cancer and malignant mesothelioma.
  • [MeSH-major] Antigens, Neoplasm / immunology. Asbestos / poisoning. Lung Neoplasms / etiology. Lung Neoplasms / immunology
  • [MeSH-minor] Aged. Aged, 80 and over. Annexin A2 / biosynthesis. Annexin A2 / immunology. Antibodies, Neoplasm / immunology. Enzyme-Linked Immunosorbent Assay. Humans. Immunity, Humoral / immunology. Immunoglobulin G / immunology. Interleukin-6 / blood. Interleukin-6 / immunology. Male. Mesothelioma / etiology. Mesothelioma / immunology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20682992.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / ANXA2 protein, human; 0 / Annexin A2; 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Immunoglobulin G; 0 / Interleukin-6; 1332-21-4 / Asbestos
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88. Pass HI, Lott D, Lonardo F, Harbut M, Liu Z, Tang N, Carbone M, Webb C, Wali A: Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. N Engl J Med; 2005 Oct 13;353(15):1564-73
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  • [Title] Asbestos exposure, pleural mesothelioma, and serum osteopontin levels.
  • BACKGROUND: We investigated the presence of osteopontin in pleural mesothelioma and determined serum osteopontin levels in three populations: subjects without cancer who were exposed to asbestos, subjects without cancer who were not exposed to asbestos, and patients with pleural mesothelioma who were exposed to asbestos.
  • METHODS: A group of 69 subjects with asbestos-related nonmalignant pulmonary disease were compared with 45 subjects without exposure to asbestos and 76 patients with surgically staged pleural mesothelioma.
  • RESULTS: There were no significant differences in mean (+/-SE) serum osteopontin levels between age-matched subjects with exposure to asbestos and subjects without exposure to asbestos (30+/-3 ng per milliliter and 20+/-4 ng per milliliter, respectively; P=0.06).
  • In the group with exposure to asbestos, elevated serum osteopontin levels were associated with pulmonary plaques and fibrosis (56+/-13 ng per milliliter) but not with normal radiographic findings (21+/-5 ng per milliliter), plaques alone (23+/-3 ng per milliliter), or fibrosis alone (32+/-7 ng per milliliter) (P=0.004).
  • Serum osteopontin levels were significantly higher in the group with pleural mesothelioma than in the group with exposure to asbestos (133+/-10 ng per milliliter vs. 30+/-3 ng per milliliter, P<0.001).
  • An analysis of serum osteopontin levels comparing the receiver-operating-characteristic curve in the group exposed to asbestos with that of the group with mesothelioma had a sensitivity of 77.6 percent and a specificity of 85.5 percent at a cutoff value of 48.3 ng of osteopontin per milliliter.
  • Subgroup analysis comparing patients with stage I mesothelioma with subjects with exposure to asbestos revealed a sensitivity of 84.6 percent and a specificity of 88.4 percent at a cutoff value of 62.4 ng of osteopontin per milliliter.
  • CONCLUSIONS: Serum osteopontin levels can be used to distinguish persons with exposure to asbestos who do not have cancer from those with exposure to asbestos who have pleural mesothelioma.
  • [MeSH-major] Asbestos / adverse effects. Asbestosis / blood. Mesothelioma / blood. Occupational Exposure. Pleural Neoplasms / blood. Sialoglycoproteins / blood
  • [MeSH-minor] Aged. Biomarkers / blood. Female. Humans. Male. Middle Aged. Neoplasm Staging. Osteopontin. ROC Curve. Regression Analysis. Survival Analysis

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  • [Copyright] Copyright 2005 Massachusetts Medical Society.
  • [CommentIn] N Engl J Med. 2005 Oct 13;353(15):1617-8 [16221786.001]
  • [CommentIn] N Engl J Med. 2006 Jan 19;354(3):304-5; author reply 304-5 [16422024.001]
  • [CommentIn] N Engl J Med. 2006 Jan 19;354(3):304-5; author reply 304-5 [16421377.001]
  • (PMID = 16221779.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin; 1332-21-4 / Asbestos
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89. Pira E, Pelucchi C, Piolatto PG, Negri E, Discalzi G, La Vecchia C: First and subsequent asbestos exposures in relation to mesothelioma and lung cancer mortality. Br J Cancer; 2007 Nov 5;97(9):1300-4
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  • [Title] First and subsequent asbestos exposures in relation to mesothelioma and lung cancer mortality.
  • We analysed data from a cohort of 1966 subjects (889 men and 1,077 women) employed by an Italian asbestos (mainly textile) company in the period 1946-1984, who were followed-up to 2004.
  • We computed standardised mortality ratios (SMR) for all causes and selected cancer sites using national death rates for each 5-year calendar period and age group.
  • There were 68 deaths from mesothelioma (25 men and 43 women, 39 pleural and 29 peritoneal) vs 1.6 expected (SMR=4,159), and 109 from lung cancer vs 35.1 expected (SMR=310).
  • The SMRs of pleural/peritoneal cancer were 6661 for subjects exposed only before 30 years of age, 8,019 for those first exposed before 30 and still employed at 30-39 years of age and 5,786 for those first exposed before 30 and still employed at 40 or more years of age.
  • The corresponding SMRs for lung cancer were 227, 446 and 562.
  • The SMR of mesothelioma was strongly related to time since first exposure.
  • The SMR of lung cancer, but not of mesothelioma, appeared to be related to subsequent exposures.
  • [MeSH-major] Asbestos / adverse effects. Lung Neoplasms / mortality. Mesothelioma / mortality. Occupational Diseases / mortality


90. Szeszenia-Dabrowska N: [Asbestos as a risk factor for pulmonary diseases]. Przegl Lek; 2008;65 Suppl 2:26-34
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  • [Title] [Asbestos as a risk factor for pulmonary diseases].
  • Asbestos is a recognised carcinogen, one of the most dangerous pollutants in the human environment.
  • This is associated with a huge accumulation of asbestos-containing materials that, as a result of their degradation, release fibres that are practically indestructible.
  • It is estimated that in recent years, asbestos was responsible for ca.
  • The pathogenic effects of asbestos on the respiratory system (the target organ) result from the inhalation of the respirable asbestos fibres suspended in the ambient air.
  • A specific feature of asbestos activity is that the pathologies appear even after cessation of the exposure; another feature is the development of mesotheliomas associated with the environmental exposure.
  • In Poland, the Act of 1997 banning the use of asbestos products has solved the problems associated with the occupational exposure in the asbestos processing industry, and prevented further accumulation of asbestos products.
  • However, problems of the environmental exposures to asbestos remain unsolved.
  • In spite that no worker has been occupationally exposed to asbestos during the recent 10 years, new cases of asbestosis, lung cancer pleural mesothelioma, non-malignant pleural diseases continue to be detected each year among the former workers of asbestos processing industry ("Amiantus" project).
  • This paper reports on the current status of asbestos-related diseases in Poland and worldwide, risk of the development of lung cancers and asbestos-specific mesotheliomas and gives recent recommendations for diagnosing and certification of asbestos-related diseases.
  • [MeSH-major] Asbestos / adverse effects. Occupational Exposure / prevention & control. Respiratory Tract Diseases / epidemiology

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  • (PMID = 19621651.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Number-of-references] 17
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91. Otsuki T, Miura Y, Maeda M, Hayashi H, Murakami S, Dong M, Nishimura Y: Keynote lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006) : -Pathophysiological Development and Immunotoxicology: what we have found from research related to silica and silicate such as asbestos-. Environ Health Prev Med; 2007 Jul;12(4):153-60
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  • [Title] Keynote lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006) : -Pathophysiological Development and Immunotoxicology: what we have found from research related to silica and silicate such as asbestos-.
  • Silica and silicates may disturb immune functions such as autoimmunity and tumor immunity, because people who are exposed to the materials sometimes develop autoimmune and malignant diseases, respectively.
  • A brief summary of our investigations related to the immunological effects of silica/asbestos is presented.
  • Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica.
  • Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors, respectively.
  • In particular, as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer in 2005 in Japan, efforts should be focused on developing a cure for these diseases to eliminate the nation wide anxiety about these malignancies.

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  • (PMID = 21432058.001).
  • [ISSN] 1342-078X
  • [Journal-full-title] Environmental health and preventive medicine
  • [ISO-abbreviation] Environ Health Prev Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2723295
  • [Keywords] NOTNLM ; apoptosis / asbestos / immunology Fas / regulatory T cell / silica
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92. Tse LA, Yu IT, Goggins W, Clements M, Wang XR, Au JS, Yu KS: Are current or future mesothelioma epidemics in Hong Kong the tragic legacy of uncontrolled use of asbestos in the past? Environ Health Perspect; 2010 Mar;118(3):382-6
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  • [Title] Are current or future mesothelioma epidemics in Hong Kong the tragic legacy of uncontrolled use of asbestos in the past?
  • Inhaled asbestos fibers may contribute to three-fourths of malignant mesotheliomas diagnosed in men and almost 40% of cases diagnosed in women.
  • Bans on the manufacture and sale of amphibole asbestos fibers are expected to reduce the incidence of mesothelioma, but the long latency period from initial exposure to clinical disease means that people exposed before bans were enacted will continue to develop asbestos-related mesotheliomas as they age.
  • Tse et al. (p. 382) used historical data on asbestos consumption and mesothelioma diagnoses to predict future mesothelioma trends in Hong Kong.
  • Asbestos use peaked during a construction boom in the early 1960s and subsequently declined by > 90% following a ban on the sale and import of crocidolite and amosite asbestos in 1996, whereas mesothelioma diagnoses in men increased from a single case in 1972–1976 to 63 cases in 2002–2006 (corresponding to crude incidence rates of 0.09 and 3.86 cases/million men, respectively).
  • However, they caution that ongoing use of chrysotile asbestos and the release of asbestos fibers from older buildings during demolition or renovation may slow the projected decline. [corrected]
  • [MeSH-major] Asbestos / adverse effects. Mesothelioma / chemically induced. Mesothelioma / epidemiology. Occupational Exposure / adverse effects

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  • (PMID = 20064790.001).
  • [ISSN] 1552-9924
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1332-21-4 / Asbestos
  • [Other-IDs] NLM/ PMC2854767
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93. Harding AH, Darnton A, Wegerdt J, McElvenny D: Mortality among British asbestos workers undergoing regular medical examinations (1971-2005). Occup Environ Med; 2009 Jul;66(7):487-95
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  • [Title] Mortality among British asbestos workers undergoing regular medical examinations (1971-2005).
  • OBJECTIVES: The Great Britain Asbestos Survey was established to monitor mortality among workers covered by regulations to control occupational exposure to asbestos.
  • This study updates the estimated burden of asbestos-related mortality in the cohort, and identifies risk factors associated with mortality.
  • The SMR for all cause mortality was 141 (95% CI 139 to 143) and for all malignant neoplasms 163 (95% CI 159 to 167).
  • CONCLUSIONS: Known associations between asbestos exposure and mortality from lung, peritoneal and pleural cancers, mesothelioma and asbestosis were confirmed, and evidence of associations with stroke and stomach cancer mortality was observed.
  • Limited evidence suggested that asbestos-related disease risk may be lower among those first exposed in more recent times.
  • [MeSH-major] Asbestos / toxicity. Neoplasms / mortality. Occupational Diseases / mortality. Occupational Exposure / adverse effects

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  • [CommentIn] Occup Environ Med. 2009 Dec;66(12):854-5 [19934119.001]
  • (PMID = 19254909.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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94. Gasparrini A, Pizzo AM, Gorini G, Seniori Costantini A, Silvestri S, Ciapini C, Innocenti A, Berry G: Prediction of mesothelioma and lung cancer in a cohort of asbestos exposed workers. Eur J Epidemiol; 2008;23(8):541-6
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  • [Title] Prediction of mesothelioma and lung cancer in a cohort of asbestos exposed workers.
  • OBJECTIVE: To predict the future deaths attributable to asbestos in a cohort of railway rolling stock workers.
  • METHODS: The future mortality of the 1,146 living workers has been computed in term of individual probability of dying for three different risks: baseline mortality, lung cancer excess, mesothelioma mortality.
  • Lung cancer mortality attributable to asbestos was calculated assuming the excess risk as stable or with a decrease after a period of time since first exposure.
  • Mesothelioma mortality was based on cumulative exposure and time since first exposure, with the inclusion of a term for clearance of asbestos fibres from the lung.
  • RESULTS: The most likely range of the number of deaths attributable to asbestos in the period 2005-2050 was 15-30 for excess of lung cancer, and 23-35 for mesothelioma.
  • CONCLUSION: This study provides predictions of asbestos-related mortality even in a selected cohort of exposed subjects, using previous knowledge about exposure-response relationship.
  • [MeSH-major] Asbestos / adverse effects. Cause of Death / trends. Lung Neoplasms / mortality. Mesothelioma / mortality. Occupational Exposure / adverse effects. Pleural Neoplasms / mortality


95. Janssen JH: [Wonder matter and assassin. The perception of the asbestos danger as a mirror of the time 1930-1990]. Gewina; 2005;28(1):38-53
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  • [Title] [Wonder matter and assassin. The perception of the asbestos danger as a mirror of the time 1930-1990].
  • In the seventies and eighties of the twentieth century the ideas of the dangers concerning the use of asbestos changed dramatically.
  • Asbestos became known as a 'silent killer' and 'the blue sand of death', and as a symbol of the hidden hazards of a deteriorating environment caused by unscrupulous companies and indolent authorities.
  • Asbestos seems to fit perfectly into the ubiquitous hazards which Ulrich Beck defines in his concept of the 'risk society' as the dangerous side effects of industrial production.
  • Yet the perception of the risk associated with asbestos depended more on socio-cultural characteristics than on scientifically risk assessments.
  • In the first half of the twentieth century the use of asbestos was limited and therefore did not cause any concern.
  • Economic crisis and war silenced the first alarming signals of asbestos related disease from foreign experts and a handful of Dutch physicians.
  • The asbestos workers themselves were held responsible for their own health and safety.
  • Preventive measures with regard to the industrial use of asbestos were prescribed by law.
  • Among asbestos workers the use of protective clothes and dust masks was generally seen as unmanly.
  • In the sixties the foreign literature on the connection between the exposure to asbestos and the occurrence of lung cancer and mesothelioma became known among Dutch specialists.
  • At the same time the trade unions rejected the idea of a shared responsibility and formulated the unilateral 'right to a safe working environment', with the implication that, in their view, all unhealthy and unsafe procedures should unconditionally be banned from the workshops, including the use of asbestos.
  • Asbestos was pointed out as a threat to the public health, tracked down all of its hiding places and ultimately removed.
  • The ban on asbestos was one of the results of democratisation and emancipation movement of the late sixties and seventies.
  • [MeSH-major] Asbestos / history. Occupational Diseases / history

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  • (PMID = 15991441.001).
  • [ISSN] 0928-303X
  • [Journal-full-title] Gewina
  • [ISO-abbreviation] Gewina
  • [Language] dut
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 1332-21-4 / Asbestos
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96. Viau A, Arnaud S, Ferrer S, Iarmacovai G, Saliba ML, Souville M, Verger P: [Factors associated with physicians' under-reporting of asbestos-related bronchopulmonary cancers. Telephone survey conducted among general practitioners and pulmonologists randomly selected in the French region of Provence-Alpes-Côte-d'Azur]. Rev Prat; 2008 Dec 15;58(19 Suppl):9-16
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  • [Title] [Factors associated with physicians' under-reporting of asbestos-related bronchopulmonary cancers. Telephone survey conducted among general practitioners and pulmonologists randomly selected in the French region of Provence-Alpes-Côte-d'Azur].
  • OBJECTIVES: To study the difficulties faced by general practitioners to detect and report asbestos-related cancers, focusing on the influence of patients' tobacco use, physicians' training and role perception.
  • 2) a clinical case (case vignette) about a lung cancer patient with occupational asbestos exposure.

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  • (PMID = 19253786.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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97. Kettunen E, Aavikko M, Nymark P, Ruosaari S, Wikman H, Vanhala E, Salmenkivi K, Pirinen R, Karjalainen A, Kuosma E, Anttila S: DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure. Br J Cancer; 2009 Apr 21;100(8):1336-42
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  • [Title] DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure.
  • Five to seven percent of lung tumours are estimated to occur because of occupational asbestos exposure.
  • Using cDNA microarrays, we have earlier detected asbestos exposure-related genomic regions in lung cancer.
  • The region at 2p was one of those that differed most between asbestos-exposed and non-exposed patients.
  • Now, we evaluated genomic alterations at 2p22.1-p16.1 as a possible marker for asbestos exposure.
  • Lung tumours from 205 patients with pulmonary asbestos fibre counts from 0 to 570 million fibres per gram of dry lung, were studied by fluorescence in situ hybridisation (FISH) for DNA copy number alterations (CNA).
  • The prevalence of loss at 2p16, shown by three different FISH probes, was significantly increased in lung tumours of asbestos-exposed patients compared with non-exposed (P=0.05).
  • In addition, a low copy number loss at 2p16 associated significantly with high-level asbestos exposure (P=0.02).
  • Furthermore, 27 of the tumours were studied for allelic imbalances (AI) at 2p22.1-p16.1 using 14 microsatellite markers and also AI at 2p16 was related to asbestos exposure (P=0.003).
  • Our results suggest that alterations at 2p16 combined with other markers could be useful in diagnosing asbestos-related lung cancer.
  • [MeSH-major] Allelic Imbalance / genetics. Asbestos / toxicity. Chromosomes, Human, Pair 2. DNA, Neoplasm / genetics. Lung Neoplasms / chemically induced. Lung Neoplasms / genetics

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  • (PMID = 19337251.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Genetic Markers; 1332-21-4 / Asbestos
  • [Other-IDs] NLM/ PMC2676554
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98. Szubert Z, Stankiewicz-Choroszucha B, Wrońska-Sobolewska M, Siewierska H, Kosińska M, Borys W, Jakubowski J, Wróbel R, Gazda U, Kedzierska B, Andrzejewski M, Sova M, Pawłowska-Koziełł H, Komorowska E, Ksiazkiewicz B, Sobala W, Szeszenia-Dabrowska N: [Prophylactic examinations of workers formerly employed in asbestos processing plants: outcome of the Amiantus project in 2000-2004]. Med Pr; 2006;57(2):101-8
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  • [Title] [Prophylactic examinations of workers formerly employed in asbestos processing plants: outcome of the Amiantus project in 2000-2004].
  • BACKGROUND: Prophylactic examinations of workers formerly employed in asbestos processing plants were performed by virtue of the Act, dated 19 June 1997, putting a ban on the production of asbestos-containing products.
  • MATERIAL AND METHODS: All the Centers perform diagnostic procedures according to the same criteria (clinical, radiological, spirometric and histological), based on the 1997 Helsinki criteria, to diagnose asbestos-related diseases.
  • Asbestosis was diagnosed in 790 persons, lung cancer in 19 persons and pleural mesothelioma in 12 persons.
  • An analysis showed the highest incidence of asbestos-related pathologies in workers of asbestos-cement plants.
  • The collected data also confirmed an upward trend in the incidence of asbestosis and changes in the lung x-ray imaging related to age, duration of employment and latency.
  • CONCLUSION: The implementation of the Amiantus project has contributed to an increased detection of pathologies related with exposure to asbestos fibers.
  • A growing proportion of radiograms, which indicate worsening of health condition provides evidence that morbid processes in the respiratory system are progressing in persons who in the past were occupationally exposed to asbestos dust.


99. Ruosaari S, Hienonen-Kempas T, Puustinen A, Sarhadi VK, Hollmén J, Knuutila S, Saharinen J, Wikman H, Anttila S: Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients. BMC Med Genomics; 2008;1:55
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  • [Title] Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients.
  • BACKGROUND: Studies on asbestos-induced tumourigenesis have indicated the role of, e.g., reactive oxygen/nitrogen species, mitochondria, as well as NF-kappaB and MAPK signalling pathways.
  • The exact molecular mechanisms contributing to asbestos-mediated carcinogenesis are, however, still to be characterized.
  • METHODS: In this study, gene expression data analyses together with gene annotation data from the Gene Ontology (GO) database were utilized to identify pathways that are differentially regulated in lung and tumour tissues between asbestos-exposed and non-exposed lung cancer patients.
  • Differentially regulated pathways were identified from gene expression data from 14 asbestos-exposed and 14 non-exposed lung cancer patients using custom-made software and Iterative Group Analysis (iGA).
  • RESULTS: Differences between asbestos-related and non-related lung tumours were detected in pathways associated with, e.g., ion transport, NF-kappaB signalling, DNA repair, as well as spliceosome and nucleosome complexes.
  • A notable fraction of the pathways down-regulated in both normal and tumour tissue of the asbestos-exposed patients were related to protein ubiquitination, a versatile process regulating, for instance, DNA repair, cell cycle, and apoptosis, and thus being also a significant contributor of carcinogenesis.
  • Even though UBA1 or UBA7, the early enzymes involved in protein ubiquitination and ubiquitin-like regulation of target proteins, did not underlie the exposure-related deregulation of ubiquitination, a difference was detected in the UBA1 and UBA7 levels between squamous cell carcinomas and respective normal lung tissue (p = 0.02 and p = 0.01) without regard to exposure status.
  • CONCLUSION: Our results indicate alterations in protein ubiquitination related both to cancer type and asbestos.
  • We present for the first time pathway analysis results on asbestos-associated lung cancer, providing important insight into the most relevant targets for future research.

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  • (PMID = 19014429.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2612681
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100. Sakai Y, Ohbayashi C, Itami H, Kajimoto K, Sakuma T, Uchino K, Yoshimura M, Matsumoto S, Idei Y, Oka T: Simple quantitative analysis of asbestos body using the sediment of formalin injected into surgically resected lung cancers. Pathol Int; 2010 Feb;60(2):78-86
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  • [Title] Simple quantitative analysis of asbestos body using the sediment of formalin injected into surgically resected lung cancers.
  • A simple screening method for quantitatively analyzing asbestos bodies that can be carried out even in community hospitals, is needed in order for laborers and neighborhoods in the vicinity of asbestos factories to apply for compensation for asbestos-related injury.
  • Eighty-eight consecutive cases of surgically resected primary lung cancer were analyzed for asbestos bodies using two methods, and the correlation between them was statistically examined.
  • The overall correlation coefficient of the concentration of asbestos bodies between the authors' method (C(AB/SED)) and the conventional method (C(AB/DLT)) was 0.4576, a weak statistically significant correlation; in patients with occupational asbestos exposure, however, the correlation coefficient was 0.7341.
  • C(AB/DLT) >3000/g dry lung tissue when C(AB/SED) is >or=3.5/mL suggests the potential for the accumulation of asbestos absorption by lung tissue.
  • [MeSH-major] Asbestos / analysis. Clinical Laboratory Techniques. Formaldehyde. Lung Neoplasms / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Occupational Exposure / adverse effects

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  • (PMID = 20398191.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 1332-21-4 / Asbestos; 1HG84L3525 / Formaldehyde
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