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76. Nashan D, Radny P, Kösters NC, Nashan B: [Skin tumors in organ-transplant recipients]. Hautarzt; 2007 Jan;58(1):48-50, 52-3
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  • [Title] [Skin tumors in organ-transplant recipients].
  • Skin cancers are a significant medical problem for organ-transplant recipients.
  • Squamous cell carcinoma and basal cell carcinoma are most common tumors.
  • An increasing incidence of melanoma, Kaposi sarcoma, Merkel cell carcinoma, as well as uncommon skin malignancies, is also seen.
  • Predisposing factors include cumulative sun exposure, cumulative immunosuppression, age, gender, skin type, virus detection and genetic alterations.
  • Skin tumors grow rapidly and their number continues to increase in the years following transplantation.
  • Large numbers of tumors, aggressive courses and appearance in young patients are other characteristics of these skin tumors.
  • In addition standardized registries are needed to assure the comparability of data, to better correlate immunosuppression with skin tumors and to plan therapeutic studies.
  • [MeSH-major] Carcinoma / epidemiology. Melanoma / epidemiology. Risk Assessment / methods. Skin Neoplasms / epidemiology. Transplants / statistics & numerical data

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  • (PMID = 16758224.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 33
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77. DeMond AL, Starr T, Dustin ML, Groves JT: Control of antigen presentation with a photoreleasable agonist peptide. J Am Chem Soc; 2006 Dec 6;128(48):15354-5
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  • The immunological synapse is a specialized intercellular junction between a T cell and a target cell that orchestrates the engagement of receptors and ligands in space and time as a means of regulating function.
  • Here we introduce a reagent for controlling the spatial and temporal presentation of natural antigen to T cells.
  • Moth cytochrome c (88-103) peptide (MCC), an agonist to the murine T cell receptor AND when presented in the context of H2 IEk major histocompatibility complex (IEk), was synthesized with the side-chain amine of Lys99 conjugated to a photosensitive protecting group, 6-nitroveratryloxycarbonyl (NVOC).
  • Cells plated on supported bilayers displaying mobile intercellular adhesion molecule-1 (ICAM-1) and NVOC-MCC loaded IEk did not form immunological synapses and exhibited low intracellular calcium levels, similar to cells presented with self-peptide.
  • [MeSH-minor] Animals. Calcium Signaling. Lipid Bilayers. Major Histocompatibility Complex / immunology. Photochemistry. Receptors, Antigen, T-Cell / immunology. Ultraviolet Rays

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  • (PMID = 17131984.001).
  • [ISSN] 0002-7863
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI044931
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipid Bilayers; 0 / Peptide Fragments; 0 / Receptors, Antigen, T-Cell
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78. Majewska H, Biernat W: Merkel cell carcinoma. Pathological and molecular aspects of diagnosis and clinical features. Pol J Pathol; 2010;61(3):117-23
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  • [Title] Merkel cell carcinoma. Pathological and molecular aspects of diagnosis and clinical features.
  • Merkel cell carcinoma (MCC) is an aggressive neoplasm of the skin usually developing in the elderly.
  • The morphological and phenotypical characteristics of Merkel cell carcinoma was recently expanded by the molecular profile.
  • The current review is a compilation of these data, which may enable better understanding of the histogenesis and potential target therapy in this rare tumour of the skin.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Chromosome Aberrations. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 6. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Prognosis. Rare Diseases

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  • (PMID = 21225493.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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79. Hu J, Yan C: Identification of deleterious non-synonymous single nucleotide polymorphisms using sequence-derived information. BMC Bioinformatics; 2008;9:297
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  • BACKGROUND: As the number of non-synonymous single nucleotide polymorphisms (nsSNPs), also known as single amino acid polymorphisms (SAPs), increases rapidly, computational methods that can distinguish disease-causing SAPs from neutral SAPs are needed.
  • Many methods have been developed to distinguish disease-causing SAPs based on both structural and sequence features of the mutation point.
  • In this study, we explore the feasibility of classifying SAPs into disease-causing and neutral mutations using only information derived from protein sequence.
  • Using the selected features, a decision tree method can achieve 82.6% overall accuracy with 0.607 Matthews Correlation Coefficient (MCC) in cross-validation.
  • When tested on an independent set that was not seen by the method during the training and feature selection, the decision tree method achieves 82.6% overall accuracy with 0.604 MCC.
  • We also evaluated the proposed method on all SAPs obtained from the Swiss-Prot, the method achieves 0.42 MCC with 73.2% overall accuracy.
  • Different from previous studies, in which only a small set of features were arbitrarily chosen and considered, here we used an automated method to systematically discover useful features from a large set of features well-annotated in public databases.

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  • (PMID = 18588693.001).
  • [ISSN] 1471-2105
  • [Journal-full-title] BMC bioinformatics
  • [ISO-abbreviation] BMC Bioinformatics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2446391
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80. Rudraraju VS, Wyandt CM: Rheology of Microcrystalline Cellulose and Sodiumcarboxymethyl Cellulose hydrogels using a controlled stress rheometer: part II. Int J Pharm; 2005 Mar 23;292(1-2):63-73
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  • Rheological properties of two different commercial grades of Microcrystalline Cellulose/Sodiumcarboxymethyl Cellulose (MCC/NaCMC) hydrogels were investigated.
  • Viscoelastic characterization of the hydrogels using a controlled stress rheometer revealed that structure formation in the gels could be detected at a concentration as low as 1.0% w/w MCC/NaCMC in purified water.
  • The elastic modulus (G') and the linear viscoelastic region (LVR) increased with increase in hydrogel concentration.
  • The frequency sweep study of the hydrogels exhibited a flat G', indicating a stable structure at 1.5% w/w and 2.0% w/w concentrations.
  • The oscillation time sweep study indicated that the rate of structure build up was dependent on the concentration of hydrogel.

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  • (PMID = 15725554.001).
  • [ISSN] 0378-5173
  • [Journal-full-title] International journal of pharmaceutics
  • [ISO-abbreviation] Int J Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hydrogels; 0 / microcrystalline cellulose; 9004-32-4 / Carboxymethylcellulose Sodium; 9004-34-6 / Cellulose
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81. Rashid M, Ramasamy S, Raghava GP: A simple approach for predicting protein-protein interactions. Curr Protein Pept Sci; 2010 Nov;11(7):589-600
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  • We achieved maximum Matthews's correlation coefficient (MCC) of 1.00, 0.52 and 0.74 for Escherichia coli, Saccharomyces cerevisiae, and Helicobacter pylori, using dipeptide based SVM model at default threshold.
  • In case of E. coli MCC decreased from 1.0 to 0.67 when evaluated on a new dataset.
  • We conclude that the primary amino acid sequence based descriptors could be used to differentiate interacting from non-interacting protein pairs.

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  • (PMID = 20887258.001).
  • [ISSN] 1875-5550
  • [Journal-full-title] Current protein & peptide science
  • [ISO-abbreviation] Curr. Protein Pept. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Dipeptides; 0 / Proteins; 0 / Saccharomyces cerevisiae Proteins
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82. Morris KL, Williams B, Kennedy GA: Images in haematology. Heavy bone marrow involvement with metastatic Merkel cell tumour in an immunosuppressed renal transplant recipient. Br J Haematol; 2005 Jan;128(2):133
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  • [Title] Images in haematology. Heavy bone marrow involvement with metastatic Merkel cell tumour in an immunosuppressed renal transplant recipient.
  • [MeSH-major] Bone Marrow Cells / pathology. Carcinoma, Merkel Cell / pathology. Carcinoma, Merkel Cell / secondary. Immunocompromised Host. Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Chromogranin A. Chromogranins / analysis. Humans. Immunohistochemistry. Intermediate Filament Proteins / analysis. Keratin-20. Kidney Transplantation. Male. Polycystic Kidney Diseases / pathology. Polycystic Kidney Diseases / surgery

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  • [CommentIn] Br J Haematol. 2005 May;129(3):446 [15842673.001]
  • (PMID = 15638845.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Chromogranins; 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / Keratin-20
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83. Luo X, Zhang G, Huang F, Rao X, He Y, Hu P: [Study on preparation of Qixian decoction pellets in tangential spray fluid bed]. Zhongguo Zhong Yao Za Zhi; 2009 Mar;34(6):690-3
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  • RESULT: the technological parameters for the preparation of blank pellets were as follows: the ratio of starch and dextrin was 2:1, the adhesive agent was 70% syrup, the rotating speed was 200 r x min(-1), the air blow flow was 15 x 20 L x min(-1), the rate of air flow was 15 L x min(-1), the spay air pressure was 0.15 MPa, and the rotating rate of spray solution pump was 20-50 r x min(-1); The optimized technological parameters for the preparation of Qixian decoction were as follows: the relative density of the extract was 1.12-1.15 g x min(-1), the diluent was MCC and its quantity was 8%, the rotating rate of spray solution pump was 10-12 mL x min(-1), the frequency of the rotor disc was 18-20 Hz, the atomizing pressure was 0.2 MPa, the frequency of the fan was 22 Hz, and the spheronisation and drying time was 30 mins.

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  • (PMID = 19624005.001).
  • [ISSN] 1001-5302
  • [Journal-full-title] Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  • [ISO-abbreviation] Zhongguo Zhong Yao Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adhesives; 0 / Drug Implants; 0 / Drugs, Chinese Herbal; 0 / qixian
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8
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4. Muh HC, Tong JC, Tammi MT: AllerHunter: a SVM-pairwise system for assessment of allergenicity and allergic cross-reactivity in proteins. PLoS One; 2009;4(6):e5861
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  • Testing results showed that AllerHunter, with a sensitivity of 83.4% and specificity of 96.4% (accuracy = 95.3%, area under the receiver operating characteristic curve AROC = 0.928+/-0.004 and Matthew's correlation coefficient MCC = 0.738), performs significantly better than a number of existing methods using an independent dataset of 1443 protein sequences.
  • [MeSH-major] Allergens / chemistry. Computational Biology / methods. Hypersensitivity / diagnosis. Hypersensitivity / genetics

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  • (PMID = 19516900.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens
  • [Other-IDs] NLM/ PMC2689655
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85. Gamblin TC, Finkelstein SD, Upsal N, Kaye JD, Blumberg D: Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer. Am Surg; 2006 May;72(5):445-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer.
  • Pathologic staging in colorectal adenocarcinoma (CA) is based on the concept that the timing of metastatic tumor spread is directly related to the depth of the primary tumor invasion.
  • To evaluate the temporal sequence of CA metastasis, we performed microdissection mutational profiling at multiple microscopic sites of primary and metastatic CA specimens.
  • Primary tumors were microdissected at the deepest point of invasion.
  • Comparative mutational profiling for different genomic loci [1p36(CCM = cutaneous malignant melanoma], 3p26(OGGI = 8 oxoguanine DNA glycosylase), 5q23 (APC, MCC = mutated in colorectal cancer), 9p21(p16/CDKN2A = cyclin-dependent kinase 2A), 10q23(PTEN = phosphatase and tensin homolog [mutated in multiple advanced cancers 11), 12p12(K-ras-2 point mutation), 17p13(TP53), 18q25(DCC= deleted in colorectal cancer) was carried out on each microdissected tissue target using microsatellite loss of heterozygosity determination or DNA sequencing.
  • All primary and metastatic sites of CA manifested acquired mutational change in 18 to 91 per cent of the genomic markers.
  • In 15/21 (71%) cases, metastatic sites lacked a specific allelic loss seen in the corresponding primary tumor, indicating that the metastasis occurred before maximal depth of primary invasion.
  • This was further supported by discordant mutational profiles between primary and secondary tumors, requiring divergent clonal evolution.
  • This is the first report describing the temporal sequence and significance of sequential mutational acquisition in clinical tissue specimens with potential implications for a new molecular pathology approach to classify human cancer.


86. Wallis S, Durham-Hall A, Tandon N, Brotherston TM, Shrestha BM: Merkel cell carcinoma. JNMA J Nepal Med Assoc; 2010 Apr-Jun;49(178):151-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma.
  • Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine tumour of the skin with high rate of local recurrence and distant metastatic potential leading to poor outcomes.
  • Merkel cells are normally found as innervated clusters of cells around hair follicles in the basal layer of the epidermis and are thought to function as touch receptors.
  • Here, we describe a case of MCC in a 71-year-old female and provide an up-to-date review of the literature pertinent to the management of MCC.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Carcinoma, Merkel Cell / surgery. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 21485603.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Nepal
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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87. Veness MJ: Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma): an overview on management. Australas J Dermatol; 2006 Aug;47(3):160-5
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  • [Title] Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma): an overview on management.
  • Merkel cell carcinoma is an uncommon but aggressive primary cutaneous neuroendocrine (small cell) carcinoma.
  • There is ongoing debate regarding the optimal treatment of this disease.
  • The early literature comprised small institutional studies with inherent weaknesses.
  • Despite this, the outcome for patients with unfavourable disease remains poor and in most series 25-30% of patients die as a direct result of Merkel cell carcinoma.
  • The head and neck is the commonest site for presentation (50-60%) and wide excision (2-3 cm) of the primary lesion is usually recommended, although achieving this is often difficult within functional and cosmetic constraints.
  • All clinically node-negative patients should be considered candidates for elective nodal treatment and those with clinical nodal disease should undergo nodal dissection and adjuvant radiotherapy.
  • Recent evidence suggests that patients treated with surgery and adjuvant locoregional radiotherapy experience a better disease-free survival compared with those undergoing surgery alone.
  • The aim of this article is to discuss relevant issues in the management of a patient with Merkel cell carcinoma.
  • [MeSH-major] Carcinoma, Merkel Cell / therapy. Skin Neoplasms / therapy

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  • (PMID = 16866994.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 50
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88. Weisser H, Hartschuh W, Greiner A, Bischof M, Enk A, Helmbold P: [Merkel cell carcinoma--clinically often misjudged]. Dtsch Med Wochenschr; 2007 Jul 30;132(30):1581-6
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  • [Title] [Merkel cell carcinoma--clinically often misjudged].
  • Merkel cell carcinoma is a rare, rapidly growing, highly malignant dermal tumor which occurs preferentially on light-exposed skin in advanced age.
  • The course of the disease is frequently characterized by the occurrence of lymph node metastases and local recurrences, even in the first year after removal of the primary tumour.
  • The histological pattern is characterized by trabecular strands of small, uniform cells with large basophilic nuclei and typical neuroendocrine granules.
  • The diagnosis is confirmed immunohistochemically by neuroendocrine and epithelial markers.
  • The excision of the primary tumor is regarded as first-line therapy.
  • In the stage of nodal disease, a combination of excision and radiotherapy is recommended.
  • Adjuvant chemotherapy can be applied in this stage, as in small-cell bronchial carcinoma.
  • Despite good response to radiatiotherapy and chemotherapy, with at least prolonged recurrence-free intervals, Merkel cell carcinoma is rarely curable at the distant metastasizing stage.
  • Individually defined, aggressive treatment,including radiatiotherapy, may in future considerably improve the prognosis, especially in the early stages of the disease.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Carcinoma, Merkel Cell / therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Skin Neoplasms / pathology. Skin Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Humans. Immunohistochemistry / methods. Lymphatic Metastasis. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 17628844.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 50
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89. Weeraratna AT, Houben R, O'Connell MP, Becker JC: Lack of Wnt5A expression in Merkel cell carcinoma. Arch Dermatol; 2010 Jan;146(1):88-9
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  • [Title] Lack of Wnt5A expression in Merkel cell carcinoma.
  • [MeSH-major] Carcinoma, Merkel Cell / genetics. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Proto-Oncogene Proteins / genetics. Skin Neoplasms / genetics. Wnt Proteins / genetics
  • [MeSH-minor] Blotting, Western. Cell Line, Tumor. Humans. Immunohistochemistry. Polymerase Chain Reaction. Wnt-5a Protein

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  • (PMID = 20083703.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 AI999999; United States / Intramural NIH HHS / /
  • [Publication-type] Letter; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Proto-Oncogene Proteins; 0 / WNT5A protein, human; 0 / Wnt Proteins; 0 / Wnt-5a Protein
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90. Heath ML, Nghiem P: Merkel cell carcinoma: if no breslow, then what? J Surg Oncol; 2007 Jun 15;95(8):614-5
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  • [Title] Merkel cell carcinoma: if no breslow, then what?
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • [CommentOn] J Surg Oncol. 2007 Jun 15;95(8):618-22 [17345617.001]
  • (PMID = 17221860.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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91. Gao LB, Kan J, Fan Y, Zhang LY, Liu SH, Chen ZN: Wirelike dinuclear ruthenium complexes connected by bis(ethynyl)oligothiophene. Inorg Chem; 2007 Jul 9;46(14):5651-64
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  • Successive increase of thiophene spacers in mixed-valence complexes {RuII}-CC(C4H2S)mCC-{RuIII} (m=1, 2, 3) induced a smooth transition from almost electronic delocalization (m=1) to localization (m=3).
  • For binuclear ruthenium complexes with intramolecular electron transfer transmitted across nine Ru-C and C-C bonds, electronic conveying capability follows {Ru}-CC(CC)2CC-{Ru}>{Ru}-CC(C4H2S)CC-{Ru}>{Ru}-CC(C6H4)CC-{Ru}>{Ru}-CC(CH=CH)2CC-{Ru}.

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  • (PMID = 17511449.001).
  • [ISSN] 0020-1669
  • [Journal-full-title] Inorganic chemistry
  • [ISO-abbreviation] Inorg Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Toskala E, Rautiainen M: Effects of surgery on the function of maxillary sinus mucosa. Eur Arch Otorhinolaryngol; 2005 Mar;262(3):236-40
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  • We examined the mucociliary clearance (MCC) in maxillary sinuses in chronic sinusitis before ESS and 6 months after the operations.
  • The correlation of histology to MCC was also studied.
  • Measurements of the mean residual mucociliary clearance (MCC) of maxillary sinuses was studied pre- and postoperatively with an isotope method.
  • Preoperative residual MCC from the maxillary sinuses was 77+/-26% (mean+/-SD).
  • Six months postoperatively, residual MCC was 70+/-22%, only slightly better than preoperatively.
  • Residual MCC was considered good (< or = 50%) in 12% of sinuses preoperatively and in 20% postoperatively.
  • As a single EM finding, metaplasia gave the poorest MCC (91%) and microvilli the best (68%).
  • MCC correlates well with the histology of the mucosa.
  • [MeSH-minor] Biopsy. Chronic Disease. Humans. Mucociliary Clearance / physiology. Time Factors

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  • [Cites] Acta Otolaryngol. 2003 Oct;123(8):954-9 [14606599.001]
  • [Cites] Laryngoscope. 1998 Mar;108(3):426-30 [9504619.001]
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  • (PMID = 15133685.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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93. Kaygusuz G, Kuzu I: Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors. Turk J Gastroenterol; 2009 Jun;20(2):83-6
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  • [Title] Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors.
  • BACKGROUND/AIMS: Friend leukemia virus integration-1 expression has been shown in a variety of tumors, including vascular tumors, desmoplastic small round cell tumor, Merkel cell carcinoma, and lymphoblastic lymphoma, in addition to Ewing's sarcoma/primitive neuroectodermal tumor.
  • The aim of the current study was to examine Friend leukemia virus integration-1 protein expression in a series of gastrointestinal stromal tumors and also to assess if Friend leukemia virus integration-1 has any role in the disease process.
  • It is the first study analyzing Friend leukemia virus integration-1 expression in gastrointestinal stromal tumors in the English literature.
  • METHODS: A tissue microarray block containing 52 cases of gastrointestinal stromal tumors was done.
  • CONCLUSIONS: Friend leukemia virus integration-1 can be expressed in a variety of tumors, and is helpful in making the diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor.
  • We think that this protein is not expressed in gastrointestinal stromal tumors and it is not a part of the pathogenesis of this disease.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Gastrointestinal Stromal Tumors / metabolism. Gene Expression. Proto-Oncogene Protein c-fli-1 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged

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  • (PMID = 19530039.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / FLI1 protein, human; 0 / Proto-Oncogene Protein c-fli-1
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94. Piérard-Franchimont C, Devillers C, Piérard GE: [Merkel cell carcinoma: from diagnosis to therapeutic management]. Rev Med Liege; 2009 Oct;64(10):500-5
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  • [Title] [Merkel cell carcinoma: from diagnosis to therapeutic management].
  • [Transliterated title] Le carcinome de Merkel: du diagnostic à la prise en charge thérapeutique.
  • Merkel cell carcinoma is a skin malignancy showing an increasing trend of incidence in the white population.
  • The diagnosis relies on the histological and targeted immunopathological examinations.
  • An assessment using medical imaging is important to establish.
  • [MeSH-major] Carcinoma, Merkel Cell / diagnosis. Carcinoma, Merkel Cell / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 19911663.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Belgium
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95. Jabbour J, Cumming R, Scolyer RA, Hruby G, Thompson JF, Lee S: Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004. Ann Surg Oncol; 2007 Jun;14(6):1943-52
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  • [Title] Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004.
  • BACKGROUND: Wide surgical excision, lymph node dissection, and radiotherapy have been used with varying efficacy in the management of early-stage Merkel cell carcinoma.
  • METHODS: Records of 82 patients with early-stage Merkel cell carcinoma between 1992 and 2004 were reviewed.
  • Twenty-nine patients presented with regional lymph node disease, which was independently associated with diminished survival (hazard ratio [HR], 4.08; 95% confidence interval [CI], 1.55-10.75; P = .005).
  • Lymphadenectomy was independently associated with prolonged disease-free survival (median, 28.5 vs. 11.8 months; HR, .46; 95% CI, .22-.94; P = .034) but not overall survival (P = .25).
  • Margin-negative excision of the primary tumor (60 of 73) was not significantly associated with either prolonged disease-free survival (median, 16 vs. 14 months) or overall survival (median, 54 vs. 34 months).
  • Forty-eight patients received radiotherapy: 36 to the primary site and 31 to the regional lymph nodes.
  • Radiotherapy to both sites was associated with a longer median time to first recurrence (primary site, 24.2 vs. 11.8 months; regional lymph nodes, 46.2 vs. 11.3 months) and survival (primary site, 53.9 vs. 45.7 months; regional lymph nodes, 103.1 vs. 34.2 months).
  • CONCLUSIONS: Adjuvant radiotherapy to the primary site after surgical excision is recommended in early-stage disease.
  • [MeSH-major] Carcinoma, Merkel Cell / surgery. Lymph Node Excision. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymph Nodes / radiation effects. Lymphatic Metastasis / pathology. Male. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Time Factors

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  • (PMID = 17356954.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Gröger A, Piatkowski A, Unglaub F, Bozkurt A, Pallua N: [Merkel cell carcinoma and immunosuppression: report of three cases and review of therapeutic options]. Handchir Mikrochir Plast Chir; 2008 Apr;40(2):105-9
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  • [Title] [Merkel cell carcinoma and immunosuppression: report of three cases and review of therapeutic options].
  • [Transliterated title] Das Merkel-Zell-Karzinom und immunsuppression: drei fallberichte und uberblick der therapeutischen optionen.
  • Merkel cell carcinoma (MCC) is a cutaneous, neuroendocrine tumour of high malignancy that is described as a firm, purple tumour localised in the dermal layer.
  • The course of disease is characterised by high relapse rate (30 - 77 %) and lymph node metastases (ca. 50 %).
  • Therapy of MCC is based on a radical surgical excision combined with sentinel lymph node biopsy (stadium I), lymph node dissection (stadium II) and postoperative radiotherapy.
  • We report three cases of MCC under immunosuppression and present therapeutic options of MCC in overview.
  • [MeSH-major] Carcinoma, Merkel Cell / surgery. Immunocompromised Host. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Arm. Cheek. Disease Progression. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Postoperative Care. Radiotherapy Dosage. Radiotherapy, Adjuvant. Sentinel Lymph Node Biopsy. Surgical Flaps. Thigh. Time Factors

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  • (PMID = 18437669.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] ger
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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97. Palomero-Gallagher N, Vogt BA, Schleicher A, Mayberg HS, Zilles K: Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. Hum Brain Mapp; 2009 Aug;30(8):2336-55
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  • It encompasses the anterior cingulate, midcingulate, posterior cingulate, and retrosplenial cortices (ACC, MCC, PCC, and RSC, respectively).
  • The hierarchical clustering analysis distinguished ACC, MCC, PCC, and RSC as independent regions.
  • The MCC has lowest AMPA, kainate, alpha(2), and D(1) densities.
  • Area 25 in ACC is similar in receptor-architecture to MCC, particularly the NMDA, GABA(A), GABA(B), and M(2) receptors.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 19034899.001).
  • [ISSN] 1097-0193
  • [Journal-full-title] Human brain mapping
  • [ISO-abbreviation] Hum Brain Mapp
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS44222
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Adrenergic; 0 / Receptors, Cholinergic; 0 / Receptors, Dopamine D1; 0 / Receptors, GABA; 0 / Receptors, Glutamate; 0 / Receptors, Serotonin
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98. Duncavage EJ, Zehnbauer BA, Pfeifer JD: Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma. Mod Pathol; 2009 Apr;22(4):516-21
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  • [Title] Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma.
  • It has recently been shown that Merkel cell carcinoma, a rare and often lethal cutaneous malignancy, frequently harbors a novel clonally integrated polyomavirus aptly named Merkel cell polyomavirus.
  • We aimed to study the prevalence of Merkel cell polyomavirus in cases of Merkel cell carcinoma, using specimens from formalin-fixed, paraffin-embedded tissue blocks.
  • In our archives we identified 41 cases of Merkel cell carcinoma (from 29 different patients).
  • Of these, 20 cases were primary cutaneous tumors, 4 were local recurrences, and 17 were metastases.
  • The detection rate of Merkel cell polyomavirus for each of the three primer sets was 22 of 29 patients (76%) for MCVPS1, 12 of 29 (41%) for LT3, and 8 of 29 (28%) for LT1.
  • Our findings provide further evidence to link Merkel cell polyomavirus with a possible role in the oncogenesis of Merkel cell carcinoma.
  • On a more practical level, our paraffin-optimized primer set may be used as an ancillary test to confirm the diagnosis of Merkel cell carcinoma in the clinical setting or for screening other rare tumor types for the causative virus, especially those tumor types that are underrepresented in frozen tissue repositories.
  • [MeSH-major] Carcinoma, Merkel Cell / virology. Polyomavirus. Polyomavirus Infections / epidemiology. Skin Neoplasms / virology. Tumor Virus Infections / epidemiology

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  • (PMID = 19252474.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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99. Javadzadeh Y, Shariati H, Movahhed-Danesh E, Nokhodchi A: Effect of some commercial grades of microcrystalline cellulose on flowability, compressibility, and dissolution profile of piroxicam liquisolid compacts. Drug Dev Ind Pharm; 2009 Feb;35(2):243-51
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  • The evaluation of effects of different grades of microcrystalline cellulose (MCC) on flowability, compressibility, and dissolution of liquisolid systems were the aims of this study.
  • For this means, several formulations were prepared using various grades of MCC as carrier.
  • The results showed that among the evaluated different grades of MCC, compacts containing MCC PH 101 and 102 showed better dissolution profiles.
  • Harder compacts were obtained using MCC PH 101 and 200 as carriers.
  • Better flowability was observed in compacts containing MCC PH 101.
  • It could be concluded that MCC PH 101 is a suitable carrier for preparing liquisolid systems for having acceptable flowability, friability, hardness, and dissolution profile.

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  • (PMID = 18785038.001).
  • [ISSN] 1520-5762
  • [Journal-full-title] Drug development and industrial pharmacy
  • [ISO-abbreviation] Drug Dev Ind Pharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Excipients; 0 / microcrystalline cellulose; 13T4O6VMAM / Piroxicam; 9004-34-6 / Cellulose
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100. Deganello A, Manciocco V, Dolivet G, Leemans CR, Spriano G: Infrahyoid fascio-myocutaneous flap as an alternative to free radial forearm flap in head and neck reconstruction. Head Neck; 2007 Mar;29(3):285-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The use of microvascular free flaps is currently the favored method for the reconstruction of defects after resection of head and neck cancer.
  • METHODS: We reviewed a series of 13 patients with defects resulting from cancer of the head and neck, who underwent infrahyoid flap reconstruction as an alternative to free radial forearm flap.
  • The series includes 12 squamous cell carcinomas arising from the oral cavity and oropharynx, and 1 Merkel cell carcinoma of the submental skin.
  • CONCLUSIONS: The IHFMCF is a versatile, reliable, and convenient flap suitable for repairing small and medium-sized defects of the oral cavity and oropharynx and obviates the need for a microvascular reconstruction.
  • [MeSH-major] Carcinoma, Merkel Cell / surgery. Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Oropharyngeal Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Laryngectomy. Male. Middle Aged. Neck Dissection. Necrosis. Pharyngectomy. Reconstructive Surgical Procedures. Retrospective Studies






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